AzTrials
AzTrials

Cardiovascular DiseasePhase 3REDEFINE 3NCT05669755

REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels

A Phase 3 study testing Cagrilintide and Semaglutide in people with Cardiovascular Disease, run by Novo Nordisk A/S at 633 sites in 25 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
Search all trials

Trial summary

This study will look at the effects of CagriSema on cardiovascular events (for example heart attack and stroke) in people living with cardiovascular disease. Participants will either get CagriSema or a dummy medicine (also called "placebo") which has no effect on the body. Read more about this study

Who is it for?
Ages 55 years and older
Conditions the study is for
Cardiovascular Disease
What is being tested?
Cagrilintide and Semaglutide
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
7,101 participants
Where
633 sitesin 25 countries
Study dates
1 Mar 2023to 14 Oct 2027
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 55 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Male or female
  • Age above or equal to 55 years at the time of signing informed consent
  • Body mass index (BMI) greater than or equal to (>=) 25.0 kilograms per meter square (kg/m^2)
  • Established CVD as evidenced by at least one of the following:
  • Prior myocardial infarction
  • Prior stroke (ischemic or haemorrhagic stroke)
Show all 18Show fewer
  • Symptomatic peripheral arterial disease (PAD) defined as at least one of the following:
  • Intermittent claudication with an ankle-brachial index (ABI) less than (<) 0.85 at rest
  • Intermittent claudication with a >= 50% stenosis in a lower extremity peripheral artery documented by X-ray angiography, magnetic resonance (MR) angiography, computed tomography (CT) angiography or Doppler ultrasound
  • Prior revascularization procedure of a lower extremity peripheral artery
  • Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g., trauma or osteomyelitis)
  • For participants with T2D at screening the following inclusion criteria also apply:
  • Diagnosed with type 2 diabetes mellitus (T2D) >= 180 days before screening
  • HbA1c 6.5%-10% (47-86 millimoles per mole [mmol/mol]) (both inclusive), as measured by central laboratory at screening
  • Treatment with either:
  • Lifestyle intervention alone
  • 1-3 marketed oral antidiabetic drugs (OADs) (metformin, α-glucosidase inhibitors (AGI), glinides, sodium-glucose co-transporter 2 inhibitor (SGLT2i), dipeptidyl peptidase 4 (DPP4)-inhibitors, thiazolidinediones, or sulphonylureas (SU) as a single agent or in combination) according to local label
  • Basal insulin alone or in combination with up to two marketed OADs, all according to local label

Who cannot join

  • Myocardial infarction, stroke, hospitalization for unstable angina pectoris or transient ischaemic attack within 60 days before screening
  • Planned coronary, carotid or peripheral artery revascularisation known on the day of screening
  • Heart failure classified as being in New York Heart Association (NYHA) Class IV at screening
  • Treatment with any glucagon-like peptide-1 (GLP-1) receptor agonist (RA) or a medication with GLP-1 activity within 90 days before screening
  • End stage renal disease defined as estimated glomerular filtration rate (eGFR) < 15 millileters per minutes per 1.73^2 (mL/min/1.73 m^2), as measured by the central laboratory at screening
  • Chronic or intermittent haemodialysis or peritoneal dialysis

Trial locations and contacts

633 sites in 25 countries.

633 sites in 25 countries

United States119 sites

  • Albany Medical College

    Albany, New York, 12203

  • Renal Medicine Associates

    Albuquerque, New Mexico, 87109

  • PharmaTex Research

    Amarillo, Texas, 79106

  • Arlington Family Res. Ctr Inc

    Arlington, Texas, 76012-4637

  • Northwest Heart Clinical Research, LLC

    Arlington Heights, Illinois, 60005

  • Ascension Saint Agnes Heart Ca

    Baltimore, Maryland, 21229

  • Heritage Valley Medical Group

    Beaver, Pennsylvania, 15009

  • National Heart Institute Cal

    Beverly Hills, California, 90211

  • Univ of Alabama Birmingham

    Birmingham, Alabama, 32533

  • Bridgeport Hospital

    Bridgeport, Connecticut, 06610

  • UNC- Chapel Hill

    Chapel Hill, North Carolina, 27599

  • Univ Diab & Endo Consultants

    Chattanooga, Tennessee, 37411

  • StudyMetrix Research LLC

    City of Saint Peters, Missouri, 63303

  • Innovative Research of W FL

    Clearwater, Florida, 33756

  • Cleveland Clinic - Main Campus

    Cleveland, Ohio, 44195

  • South Texas Clinical Research

    Corpus Christi, Texas, 78404

  • West Broadway Clinic

    Council Bluffs, Iowa, 51501

  • Valley Clinical Trials

    Covina, California, 91723

  • Louisiana Heart Center

    Covington, Louisiana, 70433

  • Baylor Scott & White Res Inst

    Dallas, Texas, 75226

  • Velocity Clinical Res-Dallas

    Dallas, Texas, 75230

  • Providence Health Partners Ctr

    Dayton, Ohio, 45439

  • Florida Premier Cardiology

    Delray Beach, Florida, 33445

  • Memorial Hospital at Gulfport

    Diamondhead, Mississippi, 39525

  • Dallas Heart and Vascular

    Duncanville, Texas, 75137

  • Duke University

    Durham, North Carolina, 27710

  • Academy of Diabetes, T&E

    El Paso, Texas, 79935

  • Lillestol Research LLC

    Fargo, North Dakota, 58104

  • Fleming Island Center for Clinical Research

    Fleming Island, Florida, 32003

  • Elite Research Center

    Flint, Michigan, 48532

  • Diabetes and Thyroid Ctr of FW

    Fort Worth, Texas, 76132

  • American Hlth Ntwk of IN LLC

    Franklin, Indiana, 46131

  • Macoupin Research Group

    Gillespie, Illinois, 62033

  • Clinical Invest Special_Gurnee

    Gurnee, Illinois, 60031

  • Louisiana Heart Center

    Hammond, Louisiana, 70403

  • Forefront Med Res Inst PLLC

    Harlingen, Texas, 78550

  • PrimeCare Medical Group

    Houston, Texas, 77024

  • Synergy Groups Medical

    Houston, Texas, 77061

  • Southwest Houston Research Ltd

    Houston, Texas, 77099

  • Rocky Mountain Diab&Osteo Ctr

    Idaho Falls, Idaho, 83404-7596

  • Clinical Research Consultants, LLC

    Kansas City, Missouri, 64111

  • Prem Internal Med Asso Houston

    Katy, Texas, 77493

  • Scripps Wht Diab Inst La Jolla

    La Jolla, California, 92037

  • Radiance Clinical Research

    Lampasas, Texas, 76550

  • First Valley Medical Group

    Lancaster, California, 93534

  • The Research Group of Lexington LLC

    Lexington, Kentucky, 40503

  • Clinical Trials Research_Sacramento

    Lincoln, California, 95648

  • Torrance Clin Res Inst, Inc.

    Lomita, California, 90717

  • DCOL Ctr for Clin Res

    Longview, Texas, 75605

  • Pacific Clinical Studies

    Los Alamitos, California, 90720

  • L-MARC Research Center

    Louisville, Kentucky, 40213

  • Texas Inst, Kdny & Endo Disor

    Lufkin, Texas, 75904

  • Ohio- Advanced Medical Research

    Maumee, Ohio, 43537

  • Texas Institute of Cardiology PA

    McKinney, Texas, 75071

  • Life Spring Research Foundation LLC

    Miami, Florida, 33130

  • Oceane 7 Medical & Research Center, Inc.

    Miami, Florida, 33144

  • Reyes Clinical Research, Inc

    Miami, Florida, 33174

  • San Marcus Res Clin Miami Lakes

    Miami Lakes, Florida, 33014

  • Floridian Clinical Research, LLC

    Miami Lakes, Florida, 33016

  • Monterey Endocrine & Diabetes Institute, Inc

    Monterey, California, 93940

  • Chambliss Clinical Trials LLC

    Montgomery, Alabama, 36106

  • Carteret Medical Group

    Morehead City, North Carolina, 28557

  • Adult Medicine of Lake County, Inc

    Mt. Dora, Florida, 32757

  • Carolina Health Specialists

    Myrtle Beach, South Carolina, 29572

  • Southern New Hampshire Diabetes and Endocrinology

    Nashua, New Hampshire, 03063

  • Eastern Nephrology Associates, PLLC

    New Bern, North Carolina, 28562

  • Tulane University Health Sciences Center

    New Orleans, Louisiana, 70112

  • Suncoast Clinical Research, Inc.

    New Port Richey, Florida, 34652

  • Mid Hudson Med Res-New Windsor

    New Windsor, New York, 12553

  • IMA Clinical Research- NY

    New York, New York, 10036

  • Capital Area Research LLC

    Newport, Pennsylvania, 17074

  • York Clinical Research LLC

    Norfolk, Virginia, 23540

  • Valley Clinical Trials, Inc.

    Northridge, California, 91325

  • VA Neb West Iowa Hlth System

    Omaha, Nebraska, 68105

  • Methodist Physicians Clin

    Omaha, Nebraska, 68114

  • Univ of NE Med Center_Omaha

    Omaha, Nebraska, 68198-6828

  • Midwest Heart & Vasc Spec

    Overland Park, Kansas, 66211

  • Desert Oasis Hlthcr Med Group

    Palm Springs, California, 92262

  • Center for Diab,Obes & Metab

    Pembroke Pines, Florida, 33024

  • Aria Endocrine Metabolic Assoc

    Philadelphia, Pennsylvania, 19114

  • Western University of Health Sciences

    Pomona, California, 91766

  • Hanson Clinical Research Center

    Port Charlotte, Florida, 33952

  • Dominion Medical Associates

    Richmond, Virginia, 23219

  • Endo Res Solutions Inc

    Roswell, Georgia, 30076

  • Texas Diabetes & Endocrinology_Round Rock

    Round Rock, Texas, 78681

  • Northeast Research Institute

    Saint Augustine, Florida, 32080

  • VA Medical Center_Salem

    Salem, Virginia, 24153-6404

  • Clinical Advancement Center

    San Antonio, Texas, 78212

  • San Antonio Prem Int Med

    San Antonio, Texas, 78220

  • Audie L. Murphy VA Hospital

    San Antonio, Texas, 78229

  • Bexar County Hospital District

    San Antonio, Texas, 78229

  • Northeast Clinical Research of San Antonio

    San Antonio, Texas, 78233

  • Linda Vista Health Care Ctr

    San Diego, California, 92111

  • N America Res Inst - San Dimas

    San Dimas, California, 91773

  • Saratoga Clinical Research

    Saratoga Springs, New York, 12866

  • Honor Health

    Scottsdale, Arizona, 85258

  • Endeavor Health

    Skokie, Illinois, 60077

  • Encompass Clinical Research_Spring Valley

    Spring Valley, California, 91978

  • Clinvest Research

    Springfield, Missouri, 65807

  • Amicis Centers of Clinical Research

    St Louis, Missouri, 63128

  • St Louis Heart & Vascular, P.C.

    St Louis, Missouri, 63136

  • Piedmont Healthcare/Research

    Statesville, North Carolina, 28625

  • Simcare Medical Research, LLC

    Sugar Land, Texas, 77478

  • Prime Global Research Inc.

    The Bronx, New York, 10456

  • Lundquist Inst.-Biom Inno-UCLA

    Torrance, California, 90502

  • Arcturus HC PLC Troy Med Res

    Troy, Michigan, 48098

  • Atlanta Heart Specialists, LLC

    Tucker, Georgia, 30084

  • Crossroads Clinical Res- Texas

    Victoria, Texas, 77901

  • Hillcrest Family Health Center

    Waco, Texas, 76708

  • Aspirus Research Institute

    Wausau, Wisconsin, 54401

  • Cardio Partners Clin Res Inst

    Wellington, Florida, 33449

  • Confluence Health Hospital

    Wenatchee, Washington, 98801

  • Valley Diab. & Endo Comp Ctr

    Weslaco, Texas, 78596

  • Iowa Diab & Endo Res Center

    West Des Moines, Iowa, 50266

  • Clinical Trials Of America

    West Monroe, Louisiana, 71291

  • Southgate Medical Group, LLP

    West Seneca, New York, 14224

  • Great Lakes Medical Research

    Westfield, New York, 14787

  • Selma Medical Associates

    Winchester, Virginia, 22601-3834

  • Brookview Hills Research Associates, LLC

    Winston-Salem, North Carolina, 27103

Other trials in United States

India78 sites

  • CIMS- Care Institute of Medical Sciences

    Ahmedabad, Gujarat, 380060

  • Marengo Asia Health Care Private Limited

    Ahmedabad, Gujarat, 380060

  • Jawahar Lal Nehru Govt. Medical College

    Ajmer, Rajasthan, 305001

  • J N Medical College

    Aligarh, Uttar Pradesh, 202002

  • J N Medical College

    Aligarh, 202002

  • All India Institute of Medical Sciences_Delhi

    Ansārinagar, New Delhi, 110029

  • Ramaiah Memorial Hospital

    Bangalore, Karnataka, 560054

  • Lifecare Hospital and Research Centre

    Bangalore, Karnataka, 560092

  • Narayana Hrudayalya Institute of Cardiac Sciences

    Bangalore, Karnataka, 560099

  • Narayana Hrudayalya Institute of Cardiac Sciences

    Bangalore, 560 099

  • AMRI Hospital

    Bhubaneswar, Odisha, 751030

  • SP Medical College

    Bikaner, Rajasthan, 334003

  • Madras Diabetes Research Foundation

    Chennai, Tamil Nadu, 600086

  • Kamalnayan Bajaj Hospital

    Chhatrapati Sambhajinagar, Maharashtra, 431005

  • Kamalnayan Bajaj Hospital

    Chhatrapati Sambhajinagar, Maharashtra, 431010

  • Kg Hospital and Post Graduate Medical Institute

    Coimbatore, Tamil Nadu, 641018

  • Shri Mahant Indiresh Hospital

    Dehradun, Uttarakhand, 248001

  • Apollo Hospital

    Delhi, New Delhi, 110076

  • Endolife Specialty Hospitals

    Guntur, Andhra Pradesh, 522001

  • Lalitha PVS Institute of Medical Sciences

    Guntur, Andhra Pradesh, 522001

  • Lalitha Super Specialities Hospital

    Guntur, Andhra Pradesh, 522001

  • Himachal Heart Institute

    Gutkar, 175021

  • Excelcare Hospital

    Guwahati, Assam, 781033

  • Ramdev Rao Hospital

    Hyderabad, Andhra Pradesh, 500072

  • Guru Nanak CARE Hospitals

    Hyderabad, Telangana, 500020

  • AIG Hospitals,Hyderabad

    Hyderabad, Telangana, 500032

  • Diabetes Research Center, Hyderabad

    Hyderabad, Telangana, 500082

  • Yashoda Hospital

    Hyderabad, Telangana, 500084

  • Mohak Bariatrics and Robotics

    Indore, Madhya Pradesh, 452007

  • SMS Medical College & Attached Hospitals

    Jaipur, Rajasthan, 302004

  • Diabetes, Thyroid and Endocrine Centre

    Jaipur, Rajasthan, 302006

  • All India Institute of Medical Sciences (AIIMS)

    Jodhpur, Rajasthan, 342005

  • All India Institute of Medical Sciences (AIIMS)

    Jodhpur, 342005

  • Krishna Institute of medical sciences

    Karad, Maharashtra, 415539

  • Krishna Institute of medical sciences

    Karad, 415539

  • All India Institute of Medical Sciences_Khurda

    Khurda, Odisha, 751019

  • Excel Endocrine Centre

    Kolhāpur, Maharashtra, 416008

  • IPGME&R and SSKM Hospital

    Kolkata, West Bengal, 700020

  • Apollo Multispeciality Hospital, Kolkata

    Kolkata, West Bengal, 700054

  • Government Medical College, Kozhikode

    Kozhikode, Kerala, 673008

  • King George's Medical University (KGMU)

    Lucknow, Uttar Pradesh, 226003

  • Sanjay Gandhi Postgraduate Institute of Medical Sciences

    Lucknow, Uttar Pradesh, 226014

  • Sanjay Gandhi Postgraduate Institute of Medical Science

    Lucknow, Uttar Pradesh, 226014

  • Christian Medical College and Hospital

    Ludhiana, Punjab, 141008

  • Omega Hospital (P) Limited

    Mangalore, Karnataka, 575002

  • Fortis Heart Institute and Multispeciality Hospital

    Mohali, Punjab, 160062

  • Sir H. N. Reliance Foundation Hospital and Research Centre

    Mumbai, Maharashtra, 400004

  • Wockhardt Hospital, Mumbai Central

    Mumbai, Maharashtra, 400011

  • Seth GS Medical College & KEM Hospital

    Mumbai, Maharashtra, 400012

  • Mysore Medical College and Research Institute

    Mysore, Karnataka, 570001

  • Hrudaya Cardiac and Vascular Care Centre

    Nagpur, Maharashtra, 440019

  • Sengupta Hospital and Research Institute

    Nagpur, Maharashtra, 440033

  • All India Institute of Medical Sciences (AIIMS), Nagpur

    Nagpur, Maharashtra, 441108

  • Shalini Tai Meghe Hospital and Research Center

    Nagpur, Maharashtra, 441110

  • Diabetes Care N' Research Centre Pvt. Ltd.

    Nagpur, 440010

  • Hrudaya Cardiac and Vascular Care Centre

    Nagpur, 440019

  • Magnum Heart Institute

    Nashik, Maharashtra, 422005

  • Magnum Heart Institute

    Nashik, 422005

  • G B Pant Institute of Postgraduate Medical Education and Research

    New Delhi, National Capital Territory of Delhi, 110002

  • G.B Pant Institute of Post Graduate medical education and research

    New Delhi, 110002

  • BL Kapur Super Specialty Hospital

    New Delhi, 110005

  • Dr. BL Kapur Memorial Hospital

    New Delhi, 110005

  • Sir Ganga Ram Hospital

    New Delhi, 110060

  • Grant Medical Foundation Ruby Hall Clinic

    Pune, Maharashtra, 411001

  • Chellaram Diabetes Institute

    Pune, Maharashtra, 411021

  • B J Medical College & Sassoon Hospital

    Pune, 411001

  • WMF's Villoo Poonawalla Memorial Hospital

    Pune, 411028.

  • SMC Heart Institute and IVF Research Centre

    Raipur, Chhattisgarh, 390001

  • SMC Heart Institute and IVF Research Centre

    Raipur, Chhattisgarh, 492007

  • Unicare heart institute and research centre

    Surat, Gujarat, 395001

  • Nirmal Hospital Pvt. Ltd.

    Surat, Gujarat, 395002

  • Citi neuro centre

    Telangana, 500034

  • Ashirwad Hospital and Research Centre

    Thane, Maharashtra, 421004

  • SSG Hospital, Baroda

    Vadodara, Gujarat, 390001

  • Bankers Heart Institute

    Vadodara, Gujarat, 390015

  • Rhythm Heart Institute

    Vadodara, Gujarat, 390022

  • Christian Medical College Hospital, Vellore

    Vellore, Tamil Nadu, 632004

  • Sunrise Hospital

    Vijayawada, Andhra Pradesh, 520002

Other trials in India

Poland57 sites

  • American Heart of Poland S.A.

    Bełchatów, Łódź Voivodeship, 97-400

  • Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio

    Bialystok, Podlaskie Voivodeship, 15-276

  • Gabinet Leczenia Otylosci i Chorob Dietozaleznych

    Bialystok, Podlaskie Voivodeship, 15-281

  • Kresmed Sp. z o. o.

    Bialystok, Podlaskie Voivodeship, 15-481

  • Osteo-Medic s.c. A. Racewicz, J. Supronik

    Bialystok, 15-351

  • Renew Clinic Sp. z o.o.

    Bialystok, 15-797

  • American Heart of Poland S.A.

    Bielsko-Biala, 43-316

  • Centrum Medyczne Kermed Renata Bijata-Bronisz I Ewa Kowalinska Sp. j.

    Bydgoszcz, 85-231

  • Gierach-Med

    Bygdoszcz, Kuyavian-Pomeranian Voivodeship, 85-796

  • Pratia S.A.

    Chojnice, 89-600

  • M2M Med. Badania Sp. z o.o.

    Chorzów, Silesian Voivodeship, 41-500

  • Malopolskie Centrum Sercowo-Naczyniowe

    Chrzanów, Lesser Poland Voivodeship, 32-500

  • NSZOZ Unica CR

    Dąbrówka, Greater Poland Voivodeship, 62-069

  • NSZOZ Unica CR

    Dąbrówka, 62-069

  • Centrum Kliniczno-Badawcze J. Brzezicki, B. Górnikiewicz-Brzezicka Lekarze Spółka Partnerska

    Elblag, 82-300

  • UCK Klinika Nadcisnienia Tetniczego i Diabetologii

    Gdansk, 80-214

  • Centrum Medyczne Pratia Gdynia

    Gdynia, Pomeranian Voivodeship, 81-338

  • Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski

    Gorzów Wielkopolski, Lubusz Voivodeship, 66-400

  • Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski

    Gorzów Wielkopolski, 66-400

  • Kardio Klinika Brynow

    Katowice, Silesian Voivodeship, 40-555

  • Pro Familia Altera Sp. z o.o.

    Katowice, Silesian Voivodeship, 40-648

  • Care Clinic Sp. z o. o.

    Katowice, 40-568

  • Uniwersyteckie Centrum Kliniczne SUM w Katowicach

    Katowice, 40-752

  • Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET

    Krakow, Lesser Poland Voivodeship, 31-261

  • Grazyna Pulka Specjalistyczny Osrodek "All-Med"

    Krakow, 30-033

  • Szpitale Powiatowe Sp. z o.o.

    Łask, 98-100

  • Gabinet Lekarski Malgorzata Saryusz-Wolska

    Lodz, 90-132

  • Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi

    Lodz, 92-213

  • Samodzielny Publiczny Zaklad Opieki Zdrowotnej Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi

    Lodz, 92-213

  • Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika

    Lodz, Łódź Voivodeship, 93-513

  • Velocity Nova Sp. z o.o.

    Lublin, Lublin Voivodeship, 20-362

  • Zanamed Medical Clinic Sp. z o.o.

    Lublin, 20-601

  • Provita Centrum Medyczne Sp. z o.o.

    Piotrkow Trybunalski, 97-300

  • ETG Poniatowa

    Poniatowa, Lublin Voivodeship, 24-320

  • Centrum Zdrowia Metabolicznego Paweł Bogdański

    Poznan, Wielkopolskie Voivodeship, 60-589

  • Centrum Zdrowia Metabolicznego

    Poznan, Wielkopolskie Voivodeship, 60-589

  • Maciej Wiza Gaja Poradnie Lekarskie

    Poznan, 61-251

  • Niepubliczny Zaklad Opieki Zdrowotnej Przychodnia Specjalistyczna A Wittek H Rudzki Sp. j.

    Ruda Śląska, Gornoslaskie, 41-709

  • Velocity Nova Sp. z o.o.

    Staszów, Świętokrzyskie Voivodeship, 28-200

  • Polsko - Amerykanskie Kliniki Serca X Oddzial Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji w Tychach

    Tychy, 43-100

  • Provita Poliklinika Sp. z o.o

    Warsaw, Masovian Province, 02-647

  • MEDI CLINICAL Badania Kliniczne

    Warsaw, Masovian Province, 02-786

  • Samodzielny Publiczny Szpital Kliniczny Im. Prof. W. Orlowskiego Centrum Medycznego Ksztalcenia Podyplomowego

    Warsaw, Masovian Voivodeship, 00-416

  • Samodzielny Publiczny Szpital Kliniczny Im. Prof. W. Orłowskiego Centrum Medycznego Kształcenia Podyplomowego

    Warsaw, Masovian Voivodeship, 00-416

  • ETG Warszawa Sp. z o.o.

    Warsaw, Masovian Voivodeship, 02-677

  • Szpital Czerniakowski Sp. z o.o.

    Warsaw, 00-739

  • Bodyclinic Sp. z o.o. sp.k.

    Warsaw, 03-712

  • NASMED

    Warsaw, 03-984

  • Regionalna Poradnia Diabetologiczna-Zytkiewicz-Jaruga, Stasinska Spolka Partnerska Lekarzy

    Wroclaw, Lower Silesian Province, 50-127

  • 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu

    Wroclaw, Lower Silesian Voivodeship, 50-981

  • 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu

    Wroclaw, Lower Silesian Voivodeship, 53-114

  • Pracownia Badan Klinicznych SALUS

    Wroclaw, 53-034

  • Slaskie Centrum Chorob Serca W Zabrzu

    Zabrze, Silesian Voivodeship, 41-800

  • Wojewodzka Poradnia dla Chorych na Cukrzyce w Zabrzu

    Zabrze, Silesian Voivodeship, 41-800

  • Wojewodzka Poradnia dla Chorych na Cukrzyce w Zabrzu

    Zabrze, 41-800

  • Velocity Nova Sp. z o.o. Velocity Zamosc

    Zamość, 22-400

  • Prywatna Praktyka Lekarska Anna Chudoba

    Żyrardów, Masovian Voivodeship, 96-300

Other trials in Poland

Bulgaria41 sites

  • SRH - Zdrave EAD

    Bankya, 1320

  • DCC - Burgas EOOD

    Burgas, 8000

  • IPSOMC - Dr. Georgi Marinov

    Burgas, 8000

  • MC Diamedical - 2013 OOD, Dimitrovgrad

    Dimitrovgrad, 6400

  • Medical centre Asclepius OOD

    Dupnitsa, Kyustendil, 2600

  • AIPSMC - DiMed EOOD

    Haskovo, 6300

  • Medical centre Zdrave 1 OOD

    Kozloduy, 3320

  • MHAT - Uni Hospital OOD

    Panagyurishte, 4500

  • "MHAT - Pazardzhik"

    Pazardzhik, 4401

  • MHAT - Pazardzhik AD

    Pazardzhik, 4401

  • Medical center Medconsult Pleven OOD

    Pleven, 5800

  • OCSOMCE - Dr. Albena Dinkova EOOD

    Pleven, 5800

  • DCC Pulmed EOOD

    Plovdiv, 4000

  • MHAT Med Line Clinic

    Plovdiv, 4000

  • UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic

    Plovdiv, 4001

  • UMHAT - Plovdiv AD

    Plovdiv, 4002

  • UMHAT Pulmed OOD - Plovdiv, Department of Endocrinology

    Plovdiv, 4002

  • MHAT Sveta Karidad EAD

    Plovdiv, 4004

  • UMHAT Medica - Ruse OOD

    Rousse, 7013

  • AIPSOMCIDEMD - Dr. Lilyana Bodurova-Troharova EOOD

    Samokov, 2000

  • MHAT Dr. Ivan Seliminski - Sliven AD

    Sliven, 8800

  • Nader Yabrudi - ASMPVBE Individual practice

    Smolyan, 4700

  • MHAT Knyaginya Klementina - Sofia EAD

    Sofia, 1233

  • MHAT Sveta Sofia EOOD

    Sofia, 1404

  • Acibadem City Clinic UMHAT Tokuda EAD, Endocrinology

    Sofia, 1407

  • UMHAT Aleksandrovska EAD, Clinic of Endocrinology and Metabolic Diseases

    Sofia, 1431

  • UMHAT Sveti Ivan Rilski EAD, Nephrology

    Sofia, 1431

  • MC Orthopaedic Center Kinov EOOD

    Sofia, 1527

  • Medical Institute of Ministry of interior

    Sofia, 1606

  • MC Diamedical - 2013 OOD, Sofia

    Sofia, 1618

  • Medical centre Vitclinic EOOD

    Sofia, 1680

  • MBAL Trakia EOOD

    Stara Zagora, 6000

  • Medical center Zara-Med EOOD

    Stara Zagora, 6000

  • Prevencia - 2000 - MCOC OOD

    Stara Zagora, 6000

  • Medical Center Nov Rehabilitatsionen center EOOD

    Stara Zagora, 6001

  • UMHAT Prof. Dr. Stoyan Kirkovich AD

    Stara Zagora, 6003

  • UMHAT Sveta Marina EAD, Clinic of Internal Diseases

    Varna, 9010

  • UMHAT Sveta Marina EAD

    Varna, 9010

  • DCC 1 Velingrad EOOD

    Velingrad, 4600

  • Medical centre Runkovi OOD

    Yambol, 8600

  • MHAT Sveti Panteleimon - Yambol AD

    Yambol, 8600

Other trials in Bulgaria

Turkey (Türkiye)36 sites

  • T.C. Saglık Bakanlıgı Adana Sehir Egitim ve Arastirma Hastan

    Adana, 01000

  • Baskent Universitesi Adana

    Adana, 01250

  • Başkent Üniversitesi Adana Dr. Turgut Noyan Uygulama ve Araştırma Merkezi

    Adana, 01250

  • Afyonkarahisar Health Sciences University

    Afyonkarahisar, 03200

  • Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji

    Afyonkarahisar, 03200

  • Baskent University Ankara Hospital

    Ankara, Bahcelievler, 06490

  • Başkent Üniversitesi Ankara Hastanesi-Endokrinoloji

    Ankara, Bahcelievler, 06490

  • Ankara Bilkent Şehir Hastanesi-Dahiliye

    Ankara, 06800

  • Ankara Sehir Hastanesi Dahiliye Klinigi

    Ankara, 06800

  • Bursa Yüksek İhtisas Eğitim ve Araştırma Merkezi-Kardiyoloji

    Bursa, Yildirim, 16110

  • Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji

    Edirne, 22030

  • Eskisehir Osmangazi University Sağlık Uygulama ve Arastirma

    Eskişehir, Odunpazari, 26040

  • Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji

    Eskişehir, Odunpazari, 26040

  • Eskişehir Şehir Hastanesi- Kardiyoloji

    Eskişehir, 26080

  • Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi

    Istanbul, Kartal, 34844

  • İstanbul Üniversitesi-Cerrahpaşa Kardiyoloji Enstitüsü

    Istanbul, 34098

  • Kanuni Sultan Suleyman Egitim ve Arastirma Hastanesi

    Istanbul, 34303

  • Seyrantepe Hamidiye Etfal Egitim ve Arastirma Hastanesi

    Istanbul, 34371

  • Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi- Seyrantepe Yerleşkesi- Endokrinoloji

    Istanbul, 34371

  • Basaksehir Cam ve Sakura Sehir Hastanesi

    Istanbul, 34480

  • Başakşehir Çam ve Sakura Şehir Hastanesi

    Istanbul, 34480

  • Göztepe Prof. Dr.Süleyman Yalçın Şehir Hastanesi- Dahiliye

    Istanbul, 34722

  • Dokuz Eylül Üniversitesi Araştırma Uygulama Hastanesi-Endokrinoloji

    Izmir, 35340

  • Kahramanmaras Sutcu Imam University

    Kahramanmaraş, 46040

  • Erciyes Universitesi Tip Fakultesi

    Kayseri, 38039

  • Erciyes Üniversitesi Hastanesi- Endokrinoloji

    Kayseri, 38039

  • Erciyes Üniversitesi Hastanesi- Kardiyoloji

    Kayseri, 38039

  • Kocaeli Universitesi Tip Fakultesi Hastanesi

    Kocaeli, 41380

  • Kocaeli Üniversitesi Hastanesi- Kardiyoloji

    Kocaeli, 41380

  • Kütahya Sağlık Bilimleri Üniversitesi Evliya Çelebi EAH- Kardiyoloji

    Kütahya, 43040

  • Mersin Üniversitesi Tip Fakültesi Hastanesi- Endokrinoloji

    Mersin, 33070

  • Mersin University Cardiology

    Mersin, 33343

  • Mersin Üniversitesi Hastanesi- Kardiyoloji

    Mersin, 33343

  • Marmara Üniversitesi Pendik EAH- Endokrinoloji

    Pendik/istanbul, 34899

  • Ondokuz Mayıs Üniversitesi Hastanesi- Kardiyoloji

    Samsun, 55200

  • Adana Şehir Eğitim ve Araştırma Hastanesi-Endokrinoloji

    Yüreğir/Adana, 1370

Other trials in Turkey (Türkiye)

Italy26 sites

  • Ente Ecclesiastico Ospedale Generale Regionale Miulli - Cardiologia e UTIC

    Acquaviva delle Fonti, 70021

  • Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona

    Ancona, 60126

  • A.O.U. Consorziale Policlinico di Bari

    Bari, BA, 70124

  • A.O.U. Bologna_ Policlinico S.Orsola Malpighi

    Bologna, 40138

  • A.O.U. Policlinico S.Orsola Malpighi

    Bologna, 40138

  • A.O.U policlinico "G. Rodolico-San Marco"

    Catania, 95123

  • Università degli studi G. D'Annunzio Chieti Pescara - CAST

    Chieti, Abruzzo, 66100

  • AOU Careggi Firenze

    Florence, Tuscany, 50134

  • Ospedale Santa Maria Goretti - UOD Diabetologia

    Latina, LT, 04100

  • Azienda Ospedaliera Luigi Sacco

    Milan, 20157

  • Azienda Ulss 3 Serenissima

    Mirano, VE, 30035

  • Azienda Ospedaliero Universitaria di Modena

    Modena, Emilia-Romagna, 41126

  • Azienda Ospedaliero Universitaria di Modena Ospedale Civile di Baggiovara

    Modena, 41126

  • Azienda Ospedaliera Universitaria Federico II di Napoli

    Naples, 80131

  • AOUP Giaccone Palermo

    Palermo, Sicily, 90127

  • Azienda Ospedaliera-Universitaria Parma

    Parma, Emilia-Romagna, 43126

  • ICS Maugeri

    Pavia, Pv, 27100

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, 56126

  • Pol. Uni. Campus Biomedico UOC Endocrinologia e Diabetologia

    Roma, 00128

  • Azienda Ospedaliero - Universitaria Sant'Andrea

    Roma, 00189

  • Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia

    Rome, Lazio, 00128

  • Fondazione Policlinico Universitario Agostino Gemelli IRCS

    Rome, RM, 00168

  • Policlinico San Donato S.p.A.

    San Donato Milanese (MI), Lombardy, 20097

  • Centro di Alta Spec. Diet., Educ. Alim. e Prev. Cardio Metab

    San Donato Milanese (MI), Mi, 20097

  • IRCCS Multimedica

    Sesto San Giovanni (MI), 20099

  • Azienda Ospedaliera Universitaria Senese

    Siena, Si, 53100

Other trials in Italy

Canada23 sites

  • Centricity Res. Barrie Endo

    Barrie, Ontario, L4N 7L3

  • Centricity Research Brampton Endocrinology

    Brampton, Ontario, L6S 0C6

  • Centricity Research Calgary Endocrinology

    Calgary, Alberta, T2H 2G4

  • Centricity Research Calgary

    Calgary, Alberta, T2H 2G4

  • C-endo Diab Endo Clin Calgery

    Calgary, Alberta, T2V 4J2

  • C-Health Partners

    Calgary, Alberta, T2V 4J2

  • Cambridge Cardiac Care Centre

    Cambridge, Ontario, N1R 6V6

  • Nova Scotia Health Authority

    Halifax, Nova Scotia, B3H 1V7

  • Wharton Medical Clinic Clinical Trials (Hamilton)

    Hamilton, Ontario, L8L 5G8

  • Premier Clinical Trial Research Network (PCTRN)

    Hamilton, Ontario, L8M 1K7

  • Ctr de recherche Clinique de Laval

    Laval, Quebec, H7T 2P5

  • Manna Research Mirabel

    Mirabel, Quebec, J7J 2K8

  • G.A. Research Associates Ltd.

    Moncton, New Brunswick, E1G 1A7

  • Applied Medical Informatics Research

    Montreal, Quebec, H4A 3T2

  • Recherche Clinique Sigma Inc.

    Québec, G1G 5X1

  • Institut universitaire de cardiologie

    Québec, G1V 4G5

  • Diex Recherche Quebec

    Québec, G1V 4T3

  • Clinique des Maladies Lipidiques de Quebec Inc.

    Québec, G1V 4W2

  • Viacar Recherche Clinique Inc.

    Saint-Lambert, Quebec, J4P-1S9

  • CHU-Sherbrooke

    Sherbrooke, Quebec, J1H 5H3

  • Ctr de méd métab de Lanaudière

    Terrebonne, Quebec, J6X 4P7

  • Diabetes Heart Research Centre

    Toronto, Ontario, M6G 1M2

  • Clinical Research Solutions Inc.

    Waterloo, Ontario, N2T 0C1

Other trials in Canada

Japan23 sites

  • Akaicho Clinic

    Chiba-shi, Chiba, 260-0804

  • Mikannohana Clinic, Diabetes, Endocrinology and Metabolism_Diabetes Internal Medicine

    Ehime, 790-0034

  • Naka Kinen Clinic_Internal medicine

    Ibaraki, 311-0113

  • Seino Internal Medicine Clinic

    Koriyama-shi, Fukushima, Japan, 963-8851

  • Seino Internal Medicine Clinic_Internal medicine

    Koriyama-shi, Fukushima, Fukushima, Japan, 963-8851

  • Jinnouchi Hospital_Internal Medicine

    Kumamoto, Kumamoto, Japan, 862-0976

  • Tokyo Saiseikai Central Hospital

    Minato-ku, Tokyo, 108-0073

  • Minami Akatsuka Clinic_internal medicine

    Mito-shi, Ibaraki, 311-4153

  • Minami Akatsuka Clinic

    Mito-shi, Ibaraki, 311-4153

  • Nanbu Tokushukai Hospital_Internal medicine

    Okinawa, 901-0493

  • Osaka NISHI-UMEDA Clinic_Internal Medicine

    Osaka, 530-0001

  • Nozaki Tokushukai Hospital_Internal medicine

    Osaka, 574-0074

  • Yao Tokushukai General Hospital_Cardiovascular division

    Osaka, 581-0011

  • Yao Tokushukai General Hospital

    Osaka, 581-0011

  • Sakurabashi Watanabe Advanced Healthcare Hospital

    Osaka-city, Osaka, 530-0005

  • Saga University Hospital, Department of Cardiology

    Saga, 849-8501

  • Kagawa Prefectural Central Hospital_Cardiovascular Medicine

    Takamatsu-shi, Kagawa, 760-8557

  • Takasaki General Medical Center_Department of Endocrinology / Metabolism Internal Medicine

    Takasaki-shi, Gunma, 370-0829

  • Tokyo-Eki Center-building Clinic_Internal Medicine

    Tokyo, 103-0027

  • Tokyo-Eki Center-building Clinic

    Tokyo, 103-0027

  • Fukuwa Clinic_Internal Medicine

    Tokyo, 104-0031

  • Japanese Red Cross Wakayama Medical Center_Diabetology and Endocrinology

    Wakayama, 640-8558

  • National Hospital Organization Saitama Hospital_Cardiology

    Wako-shi, Saitama, 351-0102

Other trials in Japan

United Kingdom23 sites

  • Heartlands Hospital - Diabetes

    Birmingham, West Midlands, B9 5SS

  • Blackpool Victoria Hospital

    Blackpool, Lancashire, FY3 8NR

  • Bradford Royal Infirmary

    Bradford, BD9 6RJ

  • The Health Centre

    Bradford on Avon, BA15 1DQ

  • Southmead Hospital

    Bristol, BS10 5NB

  • Countess of Chester Hospital - Diabetes

    Chester, CH2 1UL

  • St. Richard's Hospital_Cardiology

    Chichester, West Sussex, PO19 6SE

  • University Hospital Coventry - WISDEM Centre

    Coventry, CV2 2DX

  • Ninewells Hospital

    Dundee, DD1 9SY

  • Western General Hospital

    Edinburgh, EH4 2XU

  • Royal Devon and Exeter Hospital

    Exeter, EX2 5DW

  • Intelligent Clinical

    Glasgow, G20 0XA

  • Hull Royal Infirmary - Diabetes

    Hull, HU3 2JZ

  • Ipswich Hospital - Diabetes

    Ipswich, IP4 5PD

  • St James's University Hospital - Diabetes

    Leeds, LS9 7TF

  • Leicester General Hospital

    Leicester, LE5 4PW

  • The Good Practice

    London, SW10 0LR

  • NIHR Commercial Research Delivery Centre Newcastle

    Newcastle upon Tyne, NE1 4LP

  • Derriford Hospital

    Plymouth, PL6 5FP

  • East Surrey Hospital

    Redhill, RH1 5RH

  • Clifton Medical Centre

    Rotherham, S65 1DA

  • Staploe Medical Centre

    Soham, CB7 5JD

  • Royal Cornwall Hospital (Treliske)

    Truro, TR1 3LJ

Other trials in United Kingdom

South Africa20 sites

  • Tread Research (Pty)Ltd

    Cape Town, Western Cape, 7500

  • Prof Rayner_Division of Nephrology

    Cape Town, Western Cape, 7925

  • Cardiac Clinical Research Unit, University of Cape Town

    Cape Town, Western Cape, 7935

  • Dr A Amod

    Durban, KwaZulu-Natal, 4092

  • Netcare Umhlanga Medical Centre

    Durban, KwaZulu-Natal, 4320

  • Dr Pillay's Rooms

    Durban, KwaZulu-Natal, 4450

  • Lenmed Shifa Private Hospital

    Durban, KwaZulu-Natal, 4901

  • Soweto Clinical Trial Centre

    Johannesburg, Gauteng, 1818

  • Hemant Makan

    Johannesburg, Gauteng, 1827

  • Wits Bara Clinical Trial Site

    Johannesburg, Gauteng, 2013

  • Ezintsha Research Centre

    Johannesburg, Gauteng, 2193

  • Dr Hendrik Snyman's Practice

    Mossel Bay, Western Cape, 6500

  • Phoenix Pharma

    Port Elizabeth, Eastern Cape, 6001

  • Prinshof Medical Campus

    Pretoria, Gauteng, 0002

  • Dr Seeber

    Pretoria, Gauteng, 0083

  • Dr IO Ebrahim Inc

    Pretoria, Gauteng, 0157

  • Prof P. Joshi

    Pretoria, Gauteng, 0181

  • Jongaie Research

    Pretoria, Gauteng, 0183

  • Clinical Trial Systems (CTC)

    Pretoria, Gauteng, 0186

  • Clinical Projects Research

    Worcester, Western Cape, 6850

Other trials in South Africa

Germany19 sites

  • Diabeteszentrum-Do Dres. K U. Ch. Busch GbR

    Dortmund, 44137

  • Uniklinik TU Dresden - Med. Klinik III

    Dresden, 01307

  • Zentrum für klinische Studien Südbrandenburg GmbH

    Elsterwerda, 04910

  • InnoDiab Forschung GmbH

    Essen, 45136

  • MVZ CCB Frankfurt und Main-Taunus GbR

    Frankfurt, 60389

  • Diabetes-Zentrum Wilhelmsburg

    Hamburg, 21109

  • Diabetes-Zentrum-Wilhelmsburg GbR

    Hamburg, 21109

  • Wendisch - Dahl Hamburg - DZHW

    Hamburg, 22607

  • Uniklinik Heidelberg - Innere Medizin I

    Heidelberg, 69120

  • Universitätsklinikum Leipzig - Klinik und Poliklinik für Kardiologie

    Leipzig, 04103

  • AmBeNet GmbH

    Leipzig, 04107

  • Diabeteszentrum Ludwigsburg

    Ludwigsburg, 71634

  • Institut für Diabetesforschung GmbH Münster - Dr. med. Rose

    Münster, 48145

  • Uniklinik Münster, Klinik für Kardiologie I

    Münster, 48149

  • Universitätsklinikum Münster - Klinik für Kardiologie I

    Münster, 48149

  • RED-Institut für medizinische Forschung und Fortbildung GmbH

    Oldenburg in Holstein, 23758

  • Zentrum für klinische Studien Alexander Segner

    Saint Ingbert-Oberwürzbach, 66386

  • Al-Zoebi

    Wermsdorf, 04779

  • Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann

    Witten, 58455

Other trials in Germany

Spain18 sites

  • H.de La Ribera_Endocrinología

    Alzira, Valencia, 46600

  • Hosp. Comarcal de Antequera_Medicina Interna

    Antequera, 29200

  • Hospital Vall d'Hebron

    Barcelona, 08035

  • Hospital Vithas Sevilla

    Castilleja de la Cuesta, 41950

  • Hospital Reina Sofia

    Córdoba, 14004

  • Hospital Universitario de Fuenlabrada

    Fuenlabrada, Madrid, 28942

  • Hospital Univ. de Gran Canaria Doctor Negrín

    Las Palmas de Gran Canaria, 35010

  • Hospital Gregorio Marañón

    Madrid, 28009

  • H. Clinico Univ. Virgen de la Victoria

    Málaga, 29010

  • Hospital Clínico Virgen de la Victoria

    Málaga, 29010

  • Hospital Son Espases

    Palma de Mallorca, 07120

  • H.U. Quirónsalud Madrid

    Pozuelo de Alarcón, 28223

  • Hospital Quirón

    Pozuelo de Alarcón, 28223

  • H Virgen del Camino_Sanlúcar_Medicina Interna

    Sanlúcar de Barrameda, 11540

  • Clínica Nuevas Tecnologías en Diabetes y Endocrinología

    Seville, 41003

  • Hospital Universitario Virgen del Rocío

    Seville, 41013

  • Hospital General Universitario de Toledo

    Toledo, 45007

  • Hospital General de Valencia

    Valencia, 46014

Other trials in Spain

Argentina17 sites

  • CIPREC Pueyrredon

    Buenos Aires, C1119ACN

  • Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli

    Buenos Aires, C1425AGC

  • Mautalen Salud e investigación

    CABA, Buenos Aires, C1128 AAF

  • CEMEDIC

    CABA, Buenos Aires, C1440CFD

  • CEDIC Centro de Investigación Clínica

    CABA, C1060ABA

  • CIPREC Arenales

    CABA, C1061AAS.

  • CENUDIAB Centro Médico de Nutrición v Diabetes

    CABA, C1440AAD

  • Medical Center of Diabetes and Nutrition

    CABA, C1440AAD

  • Centro de Investigaciones Metabólicas

    Capital Federal, Buenos Aires, C1056ABI

  • Instituto Médico DAMIC

    Córdoba, X5003DCE

  • Centro Médico Privado San Vicente Diabetes

    Córdoba, X5006IKK

  • Hospital Italiano de la Plata

    La Plata, Buenos Aires, B 1900AXI

  • Instituto de Investigaciones Clinicas Mar Del Plata

    Mar del Plata, Buenos Aires, B7600FZN

  • Consultorio Integral de Atención al Diabético

    Morón, B1708IFF

  • Instituto Medico Catamarca

    Rosario, Santa Fe Province, S2000

  • Instituto de Investigaciones Clinicas San Nicolás

    San Nicolás, B2900

  • Sanatorio Norte

    Santiago del Estero, G4200

Other trials in Argentina

Australia16 sites

  • Nightingale Research Adelaide

    Adelaide, South Australia, 5000

  • Royal Adelaide Hospital - Cardiology Department

    Adelaide, South Australia, 5000

  • Advara HeartCare Auchenflower

    Auchenflower, Queensland, 4066

  • Gosford Renal Research

    Gosford, New South Wales, 2250

  • Royal Hobart Hospital

    Hobart, Tasmania, 7000

  • Advara HeartCare Joondalup

    Joondalup, Western Australia, 6027

  • Paratus Clinical

    Kanwal, New South Wales, 2259

  • Southern Neurology

    Kogarah, New South Wales, 2217

  • Advara HeartCare Leabrook

    Leabrook, South Australia, 5068

  • Liverpool Hospital

    Liverpool, New South Wales, 2170

  • Macquarie University - Clinical Trials Unit

    Macquarie Park, New South Wales, 2109

  • Logan Hospital

    Meadowbrook, Queensland, 4131

  • Baker Heart and Diabetes Institute

    Melbourne, Victoria, 3004

  • One Clinical Research

    Nedlands, Western Australia, 6009

  • Clinitrials

    Perth, Western Australia, 6000

  • Clinitrials

    West Perth, Western Australia, 6005

Other trials in Australia

Malaysia16 sites

  • Hospital Ampang

    Ampang, Selangor, 68000

  • Hospital Pulau Pinang

    George Town, Pulau Pinang, 10450

  • Hospital Serdang

    Kajang, Selangor, 43000

  • Hospital Tengku Ampuan Afzan

    Kuantan, Pahang, 25100

  • Sarawak General Hospital

    Kuching, Sarawak, 93586

  • University Malaya Medical Centre

    Lembah Pantai, Kuala Lumpur, 59100

  • Hospital Melaka

    Malacca, 75400

  • Hospital Miri

    Miri, Sarawak, 98000

  • Hospital Putrajaya

    Putrajaya, 62250

  • Hospital Miri

    Sarawak, 98000

  • Hospital Ampang

    Selangor Darul Ehsan, 68000

  • Hospital Seri Manjung

    Seri Manjung, Perak, 32040

  • Hospital Shah Alam

    Shah Alam, 40000

  • Hospital Sibu

    Sibu, Sarawak, 96000

  • Hospital Sultan Haji Ahmad Shah

    Temerluh, Pahang, 28000

  • Hospital Putrajaya

    Wilayah Persekutuan Putrajaya, 62250

Other trials in Malaysia

Brazil15 sites

  • Instituto de Pesquisa Clínica de Campinas

    Campinas, São Paulo, 13060-080

  • PUCCAMP - Hospital e Maternidade Celso Pierro

    Campinas, São Paulo, 13060-803

  • i9 Pesquisas Clínicas

    Campinas, São Paulo, 13092-133

  • Núcleo de Pesquisa Clínica S/S

    Curitiba, Paraná, 80730-150

  • Centro de Pesquisa em Diabetes Doenças Endócrino-Metabólicas

    Fortaleza, Ceará, 60430-350

  • CPHosp Manaus Medicina, Ensino e Pesquisa LTDA

    Manaus, Amazonas, 69057-088

  • Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda.

    Porto Alegre, Rio Grande do Sul, 90430-001

  • Hospital São Lucas Copacabana

    Rio de Janeiro, 22061-080

  • CIP Centro Integrado de Pesquisas do Hospital de Base

    São José do Rio Preto, São Paulo, 15090-000

  • Instituto São José dos Campos em Pesquisas Médicas

    São José dos Campos, São Paulo, 12243-280

  • Instituto de Pesquisa Clinica (IPEC)

    São Paulo, São Paulo, 01223-001

  • CPQuali Pesquisa Clínica Ltda

    São Paulo, São Paulo, 01228-000

  • CPCLIN - Centro de Pesquisas Clínicas

    São Paulo, São Paulo, 01228-200

  • CEPIC - Centro Paulista de Investigacao Clinica

    São Paulo, 04266-010

  • Centro de Diag. e Pesquisa da Osteoporose do Espírito Santo

    Vitória, Espírito Santo, 29055-450

Other trials in Brazil

Thailand15 sites

  • Siriraj Hospital

    Bangkok, Bangkok Noi, 10700

  • Vajira Hospital - Cardio

    Bangkok, 10300

  • King Chulalongkorn Memorial Hospital

    Bangkok, 10330

  • Phramongkutklao Hospital_Neurology

    Bangkok, 10400

  • Phramongkutklao Hospital

    Bangkok, 10400

  • Rajavithi Hospital_Diabetes and Endocrinology

    Bangkok, 10400

  • Ramathibodi Hospital

    Bangkok, 10400

  • Siriraj Hospital

    Bangkok, 10700

  • Maharaj Nakorn Chiang Mai

    Chiang Mai, 50200

  • RIHES-CMU_Research Institute for Health Sciences

    Chiang Mai, 50200

  • Chiang Rai Prachanukroh Hospital

    Chiang Rai, 57000

  • Srinagarind Hospital

    Khon Kaen, 40002

  • Maharat Nakhon Ratchasima Hospital

    Nakhon Ratchasima, 30000

  • Thammasat Hospital_Cardiology

    Pathum Thani, 12120

  • Songklanagarind Hospital

    Songkhla, Had-Yai, 90110

Other trials in Thailand

France14 sites

  • Centre Hospitalier d'Annonay

    Annonay, 07100

  • Centre Hospitalier Ardeche Nord

    Annonay, 07103

  • Ap-Hp-Hopital Avicenne

    Bobigny, 93000

  • Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-2

    Grenoble, 38043

  • CH Louis Pasteur

    Le Coudray, 28630

  • Les Hopitaux de Chartres-Hopital Louis Pasteur

    Le Coudray, 28630

  • Groupe Hospitalier Du Havre

    Le Havre, 76600

  • Centre Hospitalier Universitaire de Lille-Hopital Claude Huriez

    Lille, 59000

  • Centre Hospitalier Universitaire de Montpellier-Hopital Lapeyronie

    Montpellier, 34090

  • Aphp-Hopital La Pitie Salpetriere-2

    Paris, 75013

  • Hopital Novo

    Pontoise, 95300

  • Centre Hospitalier Bretagne Atlantique

    Vannes, 56000

  • Centre de Recherche Clinique Portes Du Sud

    Vénissieux, 69200

  • RESEAU DE SANTE MUTUALISTE-Médipôle Hôpital Mutualiste

    Villeurbanne, 69100

Other trials in France

Mexico13 sites

  • Promotora Medica Aguascalientes SA de CV

    Aguascalientes, 20230

  • Centro de Estudios de Investigación Metabólicos y Cardio

    Ciudad Madero, Tamaulipas, 89440

  • Instituto de Diabetes Obesidad y Nutricion S.C.

    Cuernavaca, Morelos, 62250

  • Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada, S.C.

    Culiacán, Sinaloa, 80230

  • Centro para el Desarrollo de la Medicina y la Asistencia

    Culiacán, Sinaloa, 80230

  • Centro de Investigacion Clinica Endocrinologica de Jalisco

    Guadalajara, Jalisco, 44670

  • Virgen Cardiovascular Research SC

    Guadalajara, Jalisco, 44670

  • Internal Medicine Clin Trials

    Monterrey, Nuevo León, 64020

  • Cardiolink Clin Trials S.C.

    Monterrey, Nuevo León, 64060

  • Unidad Biomedica Avanzada Monterrey

    Monterrey, Nuevo León, 64460

  • Clínica García Flores

    Monterrey, Nuevo León, 64610

  • Centro de atención e investigación cardiovascular del Potosí

    San Luis Potosí City, San Luis Potosí, 78200

  • Consultorio 1020 Hospital Angeles Xalapa

    Xalapa, Veracruz, 91193

Other trials in Mexico

Denmark10 sites

  • Aarhus Universitetshospital, Hjertesygdomme

    Aarhus N, Central Jutland, 8200

  • Aarhus Universitetshospital, Steno Diabetes Center Aarhus

    Aarhus N, 8200

  • Herlev Hospital - Afdeling for Hjertesygdomme, Forskning 1

    Herlev, Capital Region, 2730

  • Regionshospitalet Gødstrup, Hjertesygdomme

    Herning, 7400

  • Hillerød Endokrinologisk amb. H0652

    Hillerød, 3400

  • Holbæk Sygehus - Forskningsenheden, Medicinsk Afdeling, afs. 44-4

    Holbæk, Region Sjælland, 4300

  • Kolding Sygehus Karkirurgi

    Kolding, 6000

  • Slagelse Sygehus Ambulatorium for hjertesygdomme

    Slagelse, 4200

  • Svendborg Sygehus - Kardiologisk

    Svendborg, Region South, 5700

  • Viborg Sygehus

    Viborg, 8800

Other trials in Denmark

Netherlands9 sites

  • Gelre Zkh Apeldoorn

    Apeldoorn, 7334 DZ

  • Maxima MC Eindhoven

    Eindhoven, 5631 BM

  • Groene Hart Zkh Gouda

    Gouda, 2803HH

  • UMC Groningen

    Groningen, 9713 GZ

  • Frisius MC Leeuwarden

    Leeuwarden, 8934 AD

  • RadboudUMC

    Nijmegen, 6525 GA

  • Franciscus Gasthuis en Vlietland

    Rotterdam, 3045 PM

  • D & A Research B.V.

    Sneek, 8601 ZR

  • Zkh Rivierenland Tiel - Cardiologie

    Tiel, 4002 WP

Other trials in Netherlands

Serbia9 sites

  • CHC Zvezdara, Clinical department for endocrinology

    Belgrade, 11000

  • Endocrinology, Diabetes and Metabolism Diseases Clinic

    Belgrade, 11000

  • Military Medical Academy

    Belgrade, 11000

  • Clinical Hospital Center Bezanijska Kosa

    Belgrade, 11080

  • Clinical Centre Kragujevac, Internal Diseases Clinic, Endocrinology department

    Kragujevac, 34000

  • University Clinical Centre Nis

    Niš, RS, 18 000

  • Clinical Centre Nis, Endocrinology, Diabetes and Metabolism

    Niš, RS, 18000

  • Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.

    Novi Sad, Vojvodina, 21000

  • Policlinic for diabetes

    Zaječar, 19000

Other trials in Serbia

Colombia8 sites

  • Clinica de la Costa

    Barranquilla, Atlántico, 80020

  • Fundacion del Caribe para la Investigacion Biomedica-BIOS

    Barranquilla, 080020

  • CentrodeInvestigaciónenReumatologíayEspecialidadesMédicas

    Bogotá, 110221

  • Unidad de Estudios Clínicos de la Fundación Cardiovascular de Colombia

    Bucaramanga-piedecuesta, Valle Del Menzuli - Santander, Santander Department, 681012

  • FOSCAL

    Floridablanca, Santander Department, 681004

  • Servicios de Salud Ips Suramericana S.A.S.

    Medellín, Antioquia, 05001

  • Somer Sociedad Medica Rionegro S.A. Somer S.A.

    Rionegro, 054040

  • Fundación Hospital Universidad del Norte

    Soledad, Barranquilla, 83001

Other trials in Colombia

Ireland7 sites

  • Clinical Research Centre, St. Vincent's University Hospital,

    Dublin, Leinster, D04 T6F4

  • Mater Miscericordiae Hospital

    Dublin, Leinster, D07 XAO9

  • St James's CRF

    Dublin, Leinster, D08 A978

  • Connolly Hospital_Blanchardstown_Diabetes Day Centre

    Dublin, Leinster, D15 X40D

  • Mater Miscericordiae Hospital

    Dublin, Leinster, DUBLIN 7

  • CRF - Galway

    Galway, Connaght, H91 YR71

  • CRF HRB - Galway

    Galway, Connaght, H91 YR71

Other trials in Ireland

Puerto Rico1 site

  • Isis Clinical Res. Ctr P.S.C.

    Guaynabo, 00968

Other trials in Puerto Rico

About this study

Official title: The Cardiovascular Safety and Efficacy of Cagrilintide 2.4 mg s.c. in Combination With Semaglutide 2.4 mg s.c. (CagriSema 2.4 mg/2.4 mg s.c.) Once-weekly in Participants With Established Cardiovascular Disease

This study will look at the effects of CagriSema on cardiovascular events (for example heart attack and stroke) in people living with cardiovascular disease. Participants will either get CagriSema or a dummy medicine (also called "placebo") which has no effect on the body. Which treatment participants will get will be decided by chance. Participant's chance of getting CagriSema or placebo is the same. Participants will inject the study medicine once a week. The study medicine will be injected briefly with a thin needle, typically in the stomach, thighs or upper arms. The study will last for up to 4.5 years.

Being tested
Cagrilintide, Semaglutide, Placebo
Medical subject headings
Cardiovascular Diseases

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • CagrilintideDrug

    Participants will receive cagrilintide s.c. once-weekly after a dose escalation period of 16 weeks for 219 weeks.

  • SemaglutideDrug

    Participants will receive semaglutide s.c. once-weekly after a dose escalation period of 16 weeks for 219 weeks.

  • PlaceboDrug

    Participants will receive placebo matched to cagrilintide and placebo matched to semaglutide subcutaneously.

Study groups in NCT05669755
Study groupRoleWhat they receive
CagriSemaExperimentalParticipants will receive cagrilintide and semaglutide subcutaneously (s.c.) once-weekly after a dose escalation period of 16 weeks during the maintenance period of 219 weeks.
Receives: Drug: Cagrilintide; Drug: Semaglutide
PlaceboPlacebo comparatorParticipants will receive placebo matched to cagrilintide and placebo matched to semaglutide s.c. once weekly for 235 weeks.
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time to first occurrence of 3-point major adverse cardiovascular event (MACE), a composite endpoint consisting of: cardiovascular (CV) death, non-fatal myocardial infarction, non-fatal stroke

    Measured in days.

    Measured: From baseline (week 0) to end of study (up to 242 weeks or more)

Secondary outcomes (18)

  1. Time to first occurrence of a composite endpoint: Onset of persistent ≥40% reduction in eGFRcr (CKD-EPI), eGFRcr (CKD-EPI) <15 mL/min/1.73 m^2, Initiation of chronic kidney replacement therapy, Kidney death and CV death

    CKD-EPI is Chronic Kidney Disease Epidemiology Collaboration. Measured in days.

    Measured: From baseline (week 0) to end of study (up to 242 weeks or more)

  2. Time to first occurrence of composite endpoint consisting of: Onset of persistent macro albuminuria, ≥40% reduction in eGFRcr (CKD-EPI), eGFRcr (CKD-EPI) <15 mL/min/1.73 m^2, Initiation of chronic kidney replacement therapy and kidney death

    CKD-EPI is Chronic Kidney Disease Epidemiology Collaboration. Measured in days.

    Measured: From baseline (week 0) to end of study (up to 242 weeks or more)

  3. Time to first occurrence of an expanded 5-point MACE composite endpoint consisting of: CV death, non-fatal myocardial infarction, non-fatal stroke, coronary revascularisation and unstable angina requiring hospitalisation

    Measured in days.

    Measured: From baseline (week 0) to end of study (up to 242 weeks or more)

  4. Time to first occurrence of a composite endpoint consisting of: all-cause death, non-fatal myocardial infarction and non-fatal stroke

    Measured in days.

    Measured: From baseline (week 0) to end of study (up to 242 weeks or more)

  5. Time to first occurrence of myocardial infarction (fatal and non-fatal)

    Measured in days.

    Measured: From baseline (week 0) to end of study (up to 242 weeks or more)

  6. Time to first occurrence of stroke (fatal and non-fatal)

    Measured in days.

    Measured: From baseline (week 0) to end of study (up to 242 weeks or more)

  7. Change in eGFRcr (CKD-EPI)

    Measured in milliliter per min per 1.73 square meter (mL/min/1.73m^2).

    Measured: From baseline (week 0) to 120 weeks

  8. Ratio to baseline in Urine albumin-to-creatinine ratio (UACR)

    Measured in ratio.

    Measured: From baseline (week 0) to 120 weeks

  9. Relative change in body weight

    Measured in percentage (%).

    Measured: From baseline (week 0) to 120 weeks

  10. Change in waist circumference

    Measured in centimeters (cm).

    Measured: From baseline (week 0) to 120 weeks

  11. Change in waist-to-height ratio

    Measured in ratio.

    Measured: From baseline (week 0) to 120 weeks

  12. Change in systolic blood pressure (SBP)

    Measured in millimeters of mercury (mmHg).

    Measured: From baseline (week 0) to 120 weeks

  13. Change in diastolic blood pressure (DBP)

    Measured in mmHg.

    Measured: From baseline (week 0) to 120 weeks

  14. Ratio to baseline in lipids: Total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol, triglycerides and free fatty acids

    Measured in ratio.

    Measured: From baseline (week 0) to 120 weeks

  15. Change in glycated haemoglobin (HbA1c)

    Measured in percentage-points.

    Measured: From baseline (week 0) to 120 weeks

  16. Number of treatment emergent serious adverse events (TESAEs)

    Measured in count of events.

    Measured: From baseline (week 0) to end of study (up to 242 weeks or more)

  17. Number of event adjudication committee (EAC)-confirmed malignant neoplasms

    Measured as count of events.

    Measured: From baseline (week 0) to end of study (up to 242 weeks or more)

  18. Number of severe hypoglycaemic episodes (level 3) (only for participants with type 2 diabetes mellitus [T2D] at screening)

    Measured as count of events.

    Measured: From baseline (week 0) to end of study (up to 242 weeks or more)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted3 Jan 2023
  2. Study start1 Mar 2023
  3. Primary completion1 Sep 2027 (estimated)
  4. Study completion14 Oct 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
7,101 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05669755
Sponsor's protocol ID
NN9838-4942
Other IDs
U1111-1270-0943, 2021-005855-35, jRCT2031220672
Acronym
REDEFINE 3
Status last verified
Aug 2026
First submitted
20 Dec 2022
Last updated
31 Aug 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

Publications

  • Cavender MA, Jastreboff AM, Cheng AYY, Davies MJ, Donaldson L, Gerlach LO, Gylvin SH, Jacobsen JB, Marx N, Osorto Contreras CK, Le Roux CW, Lincoff AM. Design and baseline characteristics of the CagriSema cardiovascular outcomes trial (REDEFINE 3). Am Heart J. 2026 Oct 6:107626. doi: 10.1016/j.ahj.2026.107626. Online ahead of print.

    PubMed 42838477

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Cagrilintide and Semaglutide in people with Cardiovascular Disease, run by Novo Nordisk A/S at 633 sites in 25 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 18 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 31 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 633 sites in United States, India, Poland, Bulgaria, Turkey (Türkiye) and 20 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Time to first occurrence of 3-point major adverse cardiovascular event (MACE), a composite endpoint consisting of: cardiovascular (CV) death, non-fatal myocardial infarction, non-fatal stroke (time frame: From baseline (week 0) to end of study (up to 242 weeks or more)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05669755, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Aug 2026.

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