Non Hodgkin LymphomaPALSNCT05595577
Improving Exercise Capacity With a Tailored Physical Activity Intervention
A study testing Exercise with Trainerize application, Cardiopulmonary exercise testing and MRI scan in people with Non Hodgkin Lymphoma and Heart; Functional Disturbance, run by Wake Forest University Health Sciences at 2 sites in United States.
Trial summary
The purpose of this research is to test whether participating in either a physical activity intervention or a series of educational classes will help to preserve exercise capability, heart function, brain-based activities (like memory), and quality of life. Read more about this study
- Who is it for?
- Ages 18 to 85 years
- Conditions the study is for
- Non Hodgkin Lymphoma, Heart; Functional Disturbance, Hodgkin Lymphoma
- What is being tested?
- Exercise with Trainerize application, Cardiopulmonary exercise testing and MRI scan
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 105 participants
- Where
- 2 sitesUnited States
- Study dates
- 1 Mar 2023to 31 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- To be considered eligible, participants must meet all of the following criteria:
- Individuals aged 18- 85 years
- Diagnosed with stage I-IV Hodgkin's or non-Hodgkin's lymphoma or stage I-III breast cancer
- Expected to receive an anthracycline based chemotherapeutic regimen or other potentially cardiotoxic cancer therapies (e.g. chemotherapy regimens [anthracyclines, trastuzumab, rituximab]), immuno-therapies (immune checkpoint inhibitors [ICI's]) or radiation (within 8 weeks of completion of radiation).29-31
- Ability to speak and understand English
- Capacity to walk at least 2 city blocks (~.2 miles) on a flat surface
- Expected survival beyond 6 months.
- Must have an assistant that will help perform the home-based testing activities
Who cannot join
- If the patient meets any of these criteria they are excluded from the study:
- Uncontrolled hypertension (systolic blood pressure >190 mm Hg or diastolic blood pressure >100 mm Hg)
- Recent history of alcohol or drug abuse, inflammatory conditions such as lupus or inflammatory bowel disease, or another medical condition that might compromise safety or successful completion (unless approved by the participant's physician and the Principal Investigator) NOTE: In the setting of active inflammation, participation will not be approved. If chronic disease is present and stable as judged by the participant's physician and the PI, participation will be approved.
- Contraindications to MRI such as ferromagnetic cerebral aneurysm clips or other intracranial metal, pacemakers, defibrillators, functioning neurostimulator devices or other implanted electronic devices (unless approved by the participant's physician and the Principal Investigator)
- Pregnant
- Unstable angina
Show all 12Show fewer
- Contraindication for exercise training or testing
- Inability to exercise on a treadmill or stationary cycle
- Significant ventricular arrhythmias (>20 PVCs/min due to gating difficulty)
- Atrial fibrillation with uncontrolled ventricular response
- Acute myocardial infarction within 28 days
- Inability to provide informed consent
Trial locations and contacts
2 sites in 1 country.
United States2 sites
Virginia Commonwealth University
Richmond, Virginia, 23298
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem, North Carolina, 27157
About this study
Official title: Improving Exercise Capacity With a Tailored Physical Activity Intervention in Lymphoma and Breast Cancer Patients Undergoing Treatment
The purpose of this research is to test whether participating in either a physical activity intervention or a series of educational classes will help to preserve exercise capability, heart function, brain-based activities (like memory), and quality of life.
Participants will be randomized to 1 of 2 pathways:
- First pathway consists of organized health workshops. These workshops are intended to provide information on topics such as proper nutrition, management of stress, sleep practices, and emphasis on a healthy lifestyle that may help the participants through cancer treatment. This pathway will also test whether stretching may help participants through cancer treatment.
- Second pathway participants will take part in some unsupervised and some potentially supervised moderate activity sessions each week throughout participants' cancer treatment to take place either remotely or in person, depending on availability of facilities at the time visits are scheduled.
Read the detailed description
Primary Objective: To determine if a >10% difference exists in the % change (i.e., 2.06 ml/kg/min difference) in peak VO2 (volume or amount of oxygen your body consume) from baseline to 6 months of intervention between participants receiving the Physical Activity Intervention (PAI) versus Healthy Living Intervention (HLI).
Secondary Objectives:
- To determine if a >10% difference exists in the % change in peak exercise cardiac output, calculated A-VO2 difference, and pre-exercise measures of left ventricular function from baseline to 6 months of intervention between participants receiving the PAI versus HLI.
- Among these same participants, 1) to compare PAI and HLI groups on their baseline to 3 \& 6 months after initiating cancer treatment changes in 6-minWD, Health-Related Quality of Life (HRQOL), fatigue, strength, physical activity, cognitive \& physical function, 2) to determine the relationships between the 6-month time-dependent changes in these and peak VO2; and 3) to examine whether time-dependent changes in peak exercise cardiac output and/or calculated arteriovenous oxygen difference are associated with similar time-dependent changes in peak VO2.
- Assess physical activity engagement via accelerometry.
- Conditions
- Non Hodgkin Lymphoma, Heart; Functional Disturbance, Hodgkin Lymphoma, Quality of Life, Stage I Breast Cancer, Stage II Breast Cancer
- Being tested
- Exercise with Trainerize application, Cardiopulmonary exercise testing, MRI scan, Quality of Life Questionnaires, Cognitive and Brain Function Questionnaires
- Keywords
- Exercise capability, Brain activity
- Medical subject headings
- Lymphoma, Non-Hodgkin, Hodgkin Disease, Breast Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exercise with Trainerize applicationOther
1-2 sessions per week consisting of slow 15 minute aerobic warm, 20 minutes of strength training, 15 minutes progressive intensity aerobic exercise and 10 minute cool down (stretching/toning) with elastic bands.
Cardiopulmonary exercise testingDiagnostic test
Maximal peak VO2 (to monitor the body's oxygen consumption) and 6-minute exercise walking test.
MRI scanDiagnostic test
Images of the heart will be taken.
Quality of Life QuestionnairesBehavioural
Participants will be asked to complete several questionnaires that will measure fatigue, general health, social determinants of health, cognitive function (tasks that assess memory, ability to count, etc.) and physical activity. The questionnaires will take 15-40 minutes to complete.
Cognitive and Brain Function QuestionnairesBehavioural
Participants will be asked to complete several questionnaires that will measure fatigue, general health, social determinants of health, cognitive function (tasks that assess memory, ability to count, etc.) and physical activity. The questionnaires will take 15-40 minutes to complete.
Blood drawsOther
Approximately 2 teaspoons of blood withdrawn from either a vein in your arm or a currently placed central line port-a-cath. A portion of blood from each visit will be used to collect information about blood cell count.
| Study group | Role | What they receive |
|---|---|---|
| Physical Activity Intervention | Experimental | Participants will have the ability to attend one to two training sessions per week and 1-2 sessions per week at home (the 4th level of our multi-level intervention) or the location site using the Trainerize application to deliver the exercise prescription. Receives: Other: Exercise with Trainerize application; Diagnostic Test: Cardiopulmonary exercise testing; Diagnostic Test: MRI scan; Behavioral: Quality of Life Questionnaires; Behavioral: Cognitive and Brain Function Questionnaires; Other: Blood draws |
| Healthy Living Intervention (Control Arm) | Experimental | Participants randomized to the control arm will participate in organized health workshops. Each session will last 60 minutes and will be offered on location and virtually (e.g., Zoom) over 6 months. Participants will meet once a week for the first 4 weeks, biweekly for 3 months, and once a month for the last 2 months for a total of 12 sessions. Receives: Diagnostic Test: Cardiopulmonary exercise testing; Diagnostic Test: MRI scan; Behavioral: Quality of Life Questionnaires; Behavioral: Cognitive and Brain Function Questionnaires; Other: Blood draws |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Peak VO2
An analysis of covariance (ANCOVA) model will be used to assess post-intervention group differences in VO2, adjusted for baseline peak VO2.
Measured: At baseline and 6 months after study intervention
Secondary outcomes (15)
Change in Peak Exercise Cardiac Output
Measured on a continuous scale and will be analyzed using a repeated measures ANCOVA (RMANCOVA) approach.
Measured: At baseline and 6 months after study intervention
Change in Calculated A-V Oxygen Levels
Measured on a continuous scale and will be analyzed using a repeated measures ANCOVA (RMANCOVA) approach.
Measured: At baseline and 6 months after study intervention
Changes in Measurements of Pre-exercise Left Ventricular Function
Measured on a continuous scale and will be analyzed using a repeated measures ANCOVA (RMANCOVA) approach.
Measured: At baseline and 6 months after study intervention
Change in Neurocognitive Function - Hopkins Verbal Learning Test
The Hopkins Verbal Learning Test (HVLT-R) consists of memorization of a list of words to test the ability to recall immediately after memorization (immediate recall) and after a 20-minute delay (delayed recall). This test has three parts and two alternate forms. Total scores could range from 0 to 30. Lower raw scores indicate difficulties with the task.
Measured: At baseline and 6 months after study intervention
Change in Neurocognitive Function - Controlled Oral Word Association Test (COWAT)
The Controlled Oral Word Association Test is a verbal fluency test in which participants are asked to say as many words as possible from a given category and in a specified timeframe (typically 60 seconds). COWAT is measured by calculating the total number of acceptable words produced for at the given letter of the alphabet. Errors and perseverations (word repetitions) are not included in this score.
Measured: At baseline and 6 months after study intervention
Change in Neurocognitive Function - Digit Span-Backward Test
The digit span backward test is used to assess working memory. Participants are given a series of digits and asked to repeat them backward. The item score is the sum of the scores on the two trials for that item (range=0-2). The total raw score for backwards digit span is the sum of the item scores; maximum backwards digit span total raw score is 16 points.
Measured: At baseline and 6 months after study intervention
Change in Neurocognitive Function - Trail Making Test
The Trail Making Test (TMT) asks patients to connect consecutive "targets" (numbers and/or letters) on a page arranged in a specific geometric pattern. Scoring is based on time taken to complete the test (e.g. 35 seconds yielding a score of 35) with lower scores being better.
Measured: At baseline and 6 months after study intervention
Change in 6-Minute Walk Distance
Measured on a continuous scale and will be analyzed using a repeated measures ANCOVA (RMANCOVA) approach.
Measured: At baseline, 3 months and 6 months after study intervention
Health-Related Quality of Life Questionnaire (FACT-Lym or FACT-B)
FACT-Lym is 42-item questionnaire to assess the quality of life for lymphoma patients. 5-point Likert scale - 0 (not at all) to 4 (very much). Subscale domains: Physical Well-Being, Social/Family Well-Being, Emotional Well-Being, Functional Well-Being, Lymphoma Subscale. Some items are reverse scored. Subscales scores are added to get the total score. The higher the score, the better the quality of life. Scores can range from 0-168.
FACT-B is a 37-item Functional Assessment of Cancer Therapy-Breast (FACT-B) that measures five domains of health-related quality of life in breast cancer patients. These include physical, social, emotional and functional well being on a Likert scale 0-4 with (not at all) to 4 (very much). The higher the score, the better quality of life. Scores can range from 0-148.
Measured: At baseline, 3 months and 6 months after study intervention
Fatigue Questionnaire
Questionnaire to assess the difference in the level of fatigue participants experience will performing study interventions. 5-point Likert scale - 0 (not at all) to 4 (very much). The higher the score the higher level of fatigue participants experience. Score range 0-52.
Measured: At baseline, 3 months and 6 months after study intervention
Change in Physical Activity Levels - Godin Leisure Time Exercise Questionnaire
The questionnaire is a 4-item measure used to classify participants' activity levels during a typical 7-day period based on how many times on average participants exercise more than 15 minutes during their free time of strenuous, moderate or mild exercise.
Measured: At baseline, 3 months and 6 months after study intervention
Change in Physical Function - Balance Test
Participants will be asked to maintain balance for up to 30 seconds in three positions characterized by a progressive narrowing of the base support: heel of one foot beside the big toe of the other foot (semi-tandem position), heel of one foot in front of and touching the toes of the other foot (tandem position), and single leg stand.
Measured: At baseline, 3 months and 6 months after study intervention
Change in Physical Function - Chair Stand Test
The repeated chair stand test will be performed using a straight-backed chair placed with its back against a wall. Participants will be first asked to stand from a sitting position without using their arms. If they can perform the task, they will then be asked to stand up and sit down five times as quickly as possible. The time to complete the task will be recorded.
Measured: At baseline, 3 months and 6 months after study intervention
Change in Physical Function - 4-Meter Walk Gait Speed Test
The gait speed test will assess the participant's ability to walk 4 meters. Participants will be instructed to start at a marked walking course with toes touching the start line and when cued to start, will begin walking at their usual speed. The time to walk from the starting line to the end of the 4-meter walk will be recorded
Measured: At baseline, 3 months and 6 months after study intervention
Change in Physical Function - Grip Strength
Grip strength will be assessed using an isometric handgrip dynamometer while the participant is seated with the head facing straight ahead. The elbow should be bent at a 90 degree angle and the wrist should be at the mid-prone position. The participant should exert maximally and quickly (about 1 second) and two trials should be made alternately with each hand, with at least 30 seconds between trials for the same hand (recorded in kilograms).
Measured: At baseline, 3 months and 6 months after study intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Oct 2022
- Study start1 Mar 2023
- Primary completion6 Oct 2026 (estimated)
- Study completion31 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Non Hodgkin LymphomaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 105 participants (actual)
Sponsor and investigators
- Lead sponsor
- Wake Forest University Health Sciences
- Sponsor type
- University, hospital or other
- Collaborators
- National Cancer Institute (NCI)
- Responsible party
- Sponsor
- Investigators
- William Hundley, MD, Principal investigator, Wake Forest Baptist Comprehensive Cancer Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05595577
- Sponsor's protocol ID
- IRB00087763
- Other IDs
- 4R33CA226960-03, WFBCCC 98622
- Acronym
- PALS
- Status last verified
- Sep 2026
- First submitted
- 20 Oct 2022
- Last updated
- 9 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Improving Exercise Capacity With a Tailored Physical Activity Intervention in Lymphoma and Breast Cancer Patients Undergoing Treatment
- ClinicalTrials.gov ID
- NCT05595577
- Acronym / sponsor ID
- PALS / IRB00087763
- Conditions
- Non Hodgkin Lymphoma, Heart; Functional Disturbance, Hodgkin Lymphoma, Quality of Life, Stage I Breast Cancer, Stage II Breast Cancer
- Keywords
- Exercise capability, Brain activity
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 105 participants (actual)
- Lead sponsor
- Wake Forest University Health SciencesUniversity, hospital or other
- Collaborators
- National Cancer Institute (NCI)
- Study start
- 1 Mar 2023 (actual)
- Primary completion
- 6 Oct 2026 (estimated)
- Study completion
- 31 Mar 2027 (estimated)
- First posted
- 27 Oct 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this research is to test whether participating in either a physical activity intervention or a series of educational classes will help to preserve exercise capability, heart function, brain-based activities (like memory), and quality of life.
Participants will be randomized to 1 of 2 pathways:
- First pathway consists of organized health workshops. These workshops are intended to provide information on topics such as proper nutrition, management of stress, sleep practices, and emphasis on a healthy lifestyle that may help the participants through cancer treatment. This pathway will also test whether stretching may help participants through cancer treatment.
- Second pathway participants will take part in some unsupervised and some potentially supervised moderate activity sessions each week throughout participants' cancer treatment to take place either remotely or in person, depending on availability of facilities at the time visits are scheduled.
Detailed description
Primary Objective: To determine if a >10% difference exists in the % change (i.e., 2.06 ml/kg/min difference) in peak VO2 (volume or amount of oxygen your body consume) from baseline to 6 months of intervention between participants receiving the Physical Activity Intervention (PAI) versus Healthy Living Intervention (HLI).
Secondary Objectives:
- To determine if a >10% difference exists in the % change in peak exercise cardiac output, calculated A-VO2 difference, and pre-exercise measures of left ventricular function from baseline to 6 months of intervention between participants receiving the PAI versus HLI.
- Among these same participants, 1) to compare PAI and HLI groups on their baseline to 3 \& 6 months after initiating cancer treatment changes in 6-minWD, Health-Related Quality of Life (HRQOL), fatigue, strength, physical activity, cognitive \& physical function, 2) to determine the relationships between the 6-month time-dependent changes in these and peak VO2; and 3) to examine whether time-dependent changes in peak exercise cardiac output and/or calculated arteriovenous oxygen difference are associated with similar time-dependent changes in peak VO2.
- Assess physical activity engagement via accelerometry.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Physical Activity Intervention | Experimental | Other: Exercise with Trainerize application, Diagnostic Test: Cardiopulmonary exercise testing, Diagnostic Test: MRI scan, Behavioral: Quality of Life Questionnaires, Behavioral: Cognitive and Brain Function Questionnaires, Other: Blood drawsParticipants will have the ability to attend one to two training sessions per week and 1-2 sessions per week at home (the 4th level of our multi-level intervention) or the location site using the Trainerize application to deliver the exercise prescription. |
| Healthy Living Intervention (Control Arm) | Experimental | Diagnostic Test: Cardiopulmonary exercise testing, Diagnostic Test: MRI scan, Behavioral: Quality of Life Questionnaires, Behavioral: Cognitive and Brain Function Questionnaires, Other: Blood drawsParticipants randomized to the control arm will participate in organized health workshops. Each session will last 60 minutes and will be offered on location and virtually (e.g., Zoom) over 6 months. Participants will meet once a week for the first 4 weeks, biweekly for 3 months, and once a month for the last 2 months for a total of 12 sessions. |
Who may qualify
- Ages
- 18 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Individuals aged 18- 85 years
- Diagnosed with stage I-IV Hodgkin's or non-Hodgkin's lymphoma or stage I-III breast cancer
- Expected to receive an anthracycline based chemotherapeutic regimen or other potentially cardiotoxic cancer therapies (e.g. chemotherapy regimens [anthracyclines, trastuzumab, rituximab]), immuno-therapies (immune checkpoint inhibitors [ICI's]) or radiation (within 8 weeks of completion of radiation).29-31
- Ability to speak and understand English
- Capacity to walk at least 2 city blocks (~.2 miles) on a flat surface
Key exclusion criteria (12 listed)
- Uncontrolled hypertension (systolic blood pressure >190 mm Hg or diastolic blood pressure >100 mm Hg)
- Recent history of alcohol or drug abuse, inflammatory conditions such as lupus or inflammatory bowel disease, or another medical condition that might compromise safety or successful completion (unless approved by the participant's physician and the Principal Investigator) NOTE: In the setting of active inflammation, participation will not be approved. If chronic disease is present and stable as judged by the participant's physician and the PI, participation will be approved.
- Contraindications to MRI such as ferromagnetic cerebral aneurysm clips or other intracranial metal, pacemakers, defibrillators, functioning neurostimulator devices or other implanted electronic devices (unless approved by the participant's physician and the Principal Investigator)
- Pregnant
- Unstable angina
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Exercise with Trainerize application1-2 sessions per week consisting of slow 15 minute aerobic warm, 20 minutes of strength training, 15 minutes progressive intensity aerobic exercise and 10 minute cool down (stretching/toning) with elastic bands. | Other | Physical Activity Intervention |
| Cardiopulmonary exercise testingMaximal peak VO2 (to monitor the body's oxygen consumption) and 6-minute exercise walking test. | Diagnostic test | Healthy Living Intervention (Control Arm), Physical Activity Intervention |
| MRI scanImages of the heart will be taken. | Diagnostic test | Healthy Living Intervention (Control Arm), Physical Activity Intervention |
| Quality of Life QuestionnairesParticipants will be asked to complete several questionnaires that will measure fatigue, general health, social determinants of health, cognitive function (tasks that assess memory, ability to count, etc.) and physical activity. The questionnaires will take 15-40 minutes to complete. | Behavioural | Healthy Living Intervention (Control Arm), Physical Activity Intervention |
| Cognitive and Brain Function QuestionnairesParticipants will be asked to complete several questionnaires that will measure fatigue, general health, social determinants of health, cognitive function (tasks that assess memory, ability to count, etc.) and physical activity. The questionnaires will take 15-40 minutes to complete. | Behavioural | Healthy Living Intervention (Control Arm), Physical Activity Intervention |
| Blood drawsApproximately 2 teaspoons of blood withdrawn from either a vein in your arm or a currently placed central line port-a-cath. A portion of blood from each visit will be used to collect information about blood cell count. | Other | Healthy Living Intervention (Control Arm), Physical Activity Intervention |
Primary outcome
Change in Peak VO2
Time frame: At baseline and 6 months after study intervention
An analysis of covariance (ANCOVA) model will be used to assess post-intervention group differences in VO2, adjusted for baseline peak VO2.
15 secondary outcomes
Change in Peak Exercise Cardiac Output
Time frame: At baseline and 6 months after study intervention
Change in Calculated A-V Oxygen Levels
Time frame: At baseline and 6 months after study intervention
Changes in Measurements of Pre-exercise Left Ventricular Function
Time frame: At baseline and 6 months after study intervention
Change in Neurocognitive Function - Hopkins Verbal Learning Test
Time frame: At baseline and 6 months after study intervention
Change in Neurocognitive Function - Controlled Oral Word Association Test (COWAT)
Time frame: At baseline and 6 months after study intervention
Change in Neurocognitive Function - Digit Span-Backward Test
Time frame: At baseline and 6 months after study intervention
Change in Neurocognitive Function - Trail Making Test
Time frame: At baseline and 6 months after study intervention
Change in 6-Minute Walk Distance
Time frame: At baseline, 3 months and 6 months after study intervention
Health-Related Quality of Life Questionnaire (FACT-Lym or FACT-B)
Time frame: At baseline, 3 months and 6 months after study intervention
Fatigue Questionnaire
Time frame: At baseline, 3 months and 6 months after study intervention
Change in Physical Activity Levels - Godin Leisure Time Exercise Questionnaire
Time frame: At baseline, 3 months and 6 months after study intervention
Change in Physical Function - Balance Test
Time frame: At baseline, 3 months and 6 months after study intervention
Change in Physical Function - Chair Stand Test
Time frame: At baseline, 3 months and 6 months after study intervention
Change in Physical Function - 4-Meter Walk Gait Speed Test
Time frame: At baseline, 3 months and 6 months after study intervention
Change in Physical Function - Grip Strength
Time frame: At baseline, 3 months and 6 months after study intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
William Hundley, MD principal investigator
Wake Forest Baptist Comprehensive Cancer Center
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise with Trainerize application, Cardiopulmonary exercise testing and MRI scan in people with Non Hodgkin Lymphoma and Heart; Functional Disturbance, run by Wake Forest University Health Sciences at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 9 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Peak VO2 (time frame: At baseline and 6 months after study intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Sep 2026; AzTrials last refreshed its copy on 28 Oct 2026.