HealthyNCT05595382
Motivations to Transplant Registry Participation
A study testing Emotional Appeal and Rational Appeal in people with Healthy, run by Rutgers, The State University of New Jersey at 1 site in United States.
Trial summary
The current study seeks to understand factors that influence college students' likelihood of participating the National Marrow Donor Program (NMDP)/Be the Match for bone marrow and stem cell donations. Read more about this study
- Who is it for?
- Ages 18 to 35 years
- Conditions the study is for
- Healthy
- What is being tested?
- Emotional Appeal and Rational Appeal
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 397 participants
- Where
- 1 siteUnited States
- Study dates
- 10 Oct 2022to 6 Nov 2023
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Rutgers Camden Students enrolled in Psych 101 and Method and Theory
- Between the ages of 18-35
Who cannot join
- Students under 18 years of age or over 36 or older will be excluded.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Motivations for Stem Cell Transplant Registry Participation
The current study seeks to understand factors that influence college students' likelihood of participating the National Marrow Donor Program (NMDP)/Be the Match for bone marrow and stem cell donations. The secondary aim is to compare emotional and rational approaches to encouraging participation in the registry and how these approaches may impact intentions to participate in the NMDP.
Read the detailed description
This study is a randomized controlled trial that will randomize participants to receive either an emotional appeal about a child with cancer who needs a bone marrow transplant or a rational appeal using data on the racial/ethnic disparities within the transplant registry.
Participants will be recruited through the Psychology Subject Pool, which will then link students to the study measures in an online survey. Participants will be asked their age to confirm eligibility to participate (students must be between 18-35), and eligible students will be presented with the consent form through the online survey system. Participants will then be asked to complete measures of demographic information, personality/psychological characteristics, and transplant-related knowledge, intentions, and attitudes. All participants will then be given background information on bone marrow transplants.
Randomization: Students will be randomized by sex in the online survey system to the emotional presentation condition or the rational presentation condition. The emotional condition will tell the story of a fictional pediatric patient with cancer who needs a transplant. The rational condition will describe the facts about the need for diversity in the registry.
After being presented with the rational or emotional appeal, participants will again be asked about their intentions to register, their motivations for registering, and their mood.
- Conditions
- Healthy
- Being tested
- Emotional Appeal, Rational Appeal
- Keywords
- stem cell transplant, bone marrow donor, motivations, altruism
- Medical subject headings
- Altruism
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Emotional AppealBehavioural
Participants will be presented with a short vignette about a child undergoing cancer treatment and needing a bone marrow transplant in order to survive cancer.
Rational AppealBehavioural
Participants will be presented with data regarding the importance of considering race/ethnicity when looking for a bone marrow transplant donor and the likelihood of finding a match based on the patient's racial/ethnic background.
| Study group | Role | What they receive |
|---|---|---|
| Emotional Group | Experimental | Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex. Receives: Behavioral: Emotional Appeal |
| Rational Group | Experimental | Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex. Receives: Behavioral: Rational Appeal |
What is being measured
The primary outcome is the main question the study is designed to answer.
Intention to Register
Participants rated the likelihood of registering on a 1-7 scale with higher scores indicating greater intention to join the registry (better outcome). Participants were asked these questions before (baseline) and after (post-intervention) the experimental manipulation.
Measured: Baseline and after the experimental manipulation (Post-Intervention)
Secondary outcomes (2)
Mood
Participant mood was assessed on a 1-10 scale, with higher scores indicating a better mood. Participants were asked these questions before (baseline) and after (post-intervention) the experimental manipulation.
Measured: Baseline and after experimental manipulation (Post-Intervention)
Psychosocial and Demographic Correlates of Intentions to Register--Knowledge
Participants completed a knowledge measure about bone marrow and stem cell transplant donation using true/false statements about transplant donation that was examined as a correlate of their intentions to register with the transplant registry. The measure was scored as a percent of items answered correctly, higher scores indicating better knowledge.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Oct 2022
- Study start10 Oct 2022
- Primary completion6 Nov 2023
- Study completion6 Nov 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (18)Papers the sponsor has linked to this study.
- Other trials for HealthyStudies of the same condition, open and under way.
- More trials run by Rutgers, The State University of New JerseyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 397 participants (actual)
Sponsor and investigators
- Lead sponsor
- Rutgers, The State University of New Jersey
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Lauren C. Daniel, Ph.D., Rutgers, The State University of New Jersey
- Investigators
- Lauren C Daniel, Ph.D., Principal investigator, Rutgers University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05595382
- Sponsor's protocol ID
- Pro2022000536
- Status last verified
- Apr 2025
- First submitted
- 15 Sep 2022
- Last updated
- 18 Apr 2025
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Billen A, Madrigal JA, Scior K, Shaw BE, Strydom A. Donation of peripheral blood stem cells to unrelated strangers: A thematic analysis. PLoS One. 2017 Oct 25;12(10):e0186438. doi: 10.1371/journal.pone.0186438. eCollection 2017.
PubMed 29069088Butterworth VA, Simmons RG, Bartsch G, Randall B, Schimmel M, Stroncek DF. Psychosocial effects of unrelated bone marrow donation: experiences of the National Marrow Donor Program. Blood. 1993 Apr 1;81(7):1947-59.
PubMed 8461479CROWNE DP, MARLOWE D. A new scale of social desirability independent of psychopathology. J Consult Psychol. 1960 Aug;24:349-54. doi: 10.1037/h0047358. No abstract available.
PubMed 13813058Fingrut W, Parmar S, Cuperfain A, Rikhraj K, Charman E, Ptak E, Kahlon M, Graham A, Luong S, Wang YG, Yu J, Arora N, Suppiah R, Li EW, Lee A, Welsh C, Benzaquen M, Thatcher A, Baharmand I, Ladd A, Petraszko T, Allan D, Messner H. The Stem Cell Club: a model for unrelated stem cell donor recruitment. Transfusion. 2017 Dec;57(12):2928-2936. doi: 10.1111/trf.14327. Epub 2017 Sep 24.
PubMed 28944484Gardner, Paul. (1987). Measuring ambivalence to science. Journal of Research in Science Teaching. 24. 241 - 247. 10.1002/tea.3660240305.
Kaster EC, Rogers CR, Jeon KC, Rosen B. Getting to the Heart of Being the Match: A Qualitative Analysis of Bone Marrow Donor Recruitment and Retention Among College Students. Health Educ (Muncie). 2014 Spring;46(1):14-19.
PubMed 25632376Monaghan M, Yi QL, Green M, Campbell T, Weiss JT, Dibdin N, Mercer D, Elmoazzen H, Allan DS. Factors associated with registrant availability for unrelated adult donor hematopoietic stem cell donation: Analysis of the stem cell registry at Canadian Blood Services. Transfusion. 2021 Jan;61(1):24-28. doi: 10.1111/trf.16129. Epub 2020 Oct 21.
PubMed 33084098Narayanan P, Wolanskyj A, Ehlers SL, Litzow MR, Patnaik MS, Hogan WJ, Hashmi SK. Medical Students' Knowledge, Familiarity, and Attitudes towards Hematopoietic Stem Cell Donation: Stem Cell Donation Behaviors. Biol Blood Marrow Transplant. 2016 Sep;22(9):1710-1716. doi: 10.1016/j.bbmt.2016.06.014. Epub 2016 Jun 22.
PubMed 27343721National Marrow Donor Program (2013). Key Figures and Facts. www.bethematch.com
Onitilo AA, Lin YH, Okonofua EC, Afrin LB, Ariail J, Tilley BC. Race, education, and knowledge of bone marrow registry: indicators of willingness to donate bone marrow among African Americans and Caucasians. Transplant Proc. 2004 Dec;36(10):3212-9. doi: 10.1016/j.transproceed.2004.10.019.
PubMed 15686731Rose A, Peters N, Shea JA, Armstrong K. Development and testing of the health care system distrust scale. J Gen Intern Med. 2004 Jan;19(1):57-63. doi: 10.1111/j.1525-1497.2004.21146.x.
PubMed 14748861Rosenberg, M. (1965). Rosenberg self-esteem scale. Journal of Religion and Health.
Rushton, J. P., Chrisjohn, R. D., & Fekken, G. C. (1981). The altruistic personality and the self-report altruism scale. Personality and individual differences, 2(4), 293-302.
Surana, P. K., & Lomas, T. (2014). The power of charity: Does giving away money improve the wellbeing of the donor. Indian Journal of Positive Psychology, 5(3), 223-230.
Studts JL, Ruberg JL, McGuffin SA, Roetzer LM. Decisions to register for the National Marrow Donor Program: rational vs emotional appeals. Bone Marrow Transplant. 2010 Mar;45(3):422-8. doi: 10.1038/bmt.2009.174. Epub 2009 Aug 3.
PubMed 19648972
Study at a glance
From the registry record, last updated by the sponsor on 18 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Motivations for Stem Cell Transplant Registry Participation
- ClinicalTrials.gov ID
- NCT05595382
- Acronym / sponsor ID
- Pro2022000536
- Conditions
- Healthy
- Keywords
- stem cell transplant, bone marrow donor, motivations, altruism
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 397 participants (actual)
- Lead sponsor
- Rutgers, The State University of New JerseyUniversity, hospital or other
- Study start
- 10 Oct 2022 (actual)
- Primary completion
- 6 Nov 2023 (actual)
- Study completion
- 6 Nov 2023 (actual)
- First posted
- 27 Oct 2022 (actual)
- Results
- Posted 18 Apr 2025
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The current study seeks to understand factors that influence college students' likelihood of participating the National Marrow Donor Program (NMDP)/Be the Match for bone marrow and stem cell donations. The secondary aim is to compare emotional and rational approaches to encouraging participation in the registry and how these approaches may impact intentions to participate in the NMDP.
Detailed description
This study is a randomized controlled trial that will randomize participants to receive either an emotional appeal about a child with cancer who needs a bone marrow transplant or a rational appeal using data on the racial/ethnic disparities within the transplant registry.
Participants will be recruited through the Psychology Subject Pool, which will then link students to the study measures in an online survey. Participants will be asked their age to confirm eligibility to participate (students must be between 18-35), and eligible students will be presented with the consent form through the online survey system. Participants will then be asked to complete measures of demographic information, personality/psychological characteristics, and transplant-related knowledge, intentions, and attitudes. All participants will then be given background information on bone marrow transplants.
Randomization: Students will be randomized by sex in the online survey system to the emotional presentation condition or the rational presentation condition. The emotional condition will tell the story of a fictional pediatric patient with cancer who needs a transplant. The rational condition will describe the facts about the need for diversity in the registry.
After being presented with the rational or emotional appeal, participants will again be asked about their intentions to register, their motivations for registering, and their mood.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Emotional Group | Experimental | Behavioral: Emotional AppealParticipants will be randomly assigned to receive an emotional or rational appeal, stratified by sex. |
| Rational Group | Experimental | Behavioral: Rational AppealParticipants will be randomly assigned to receive an emotional or rational appeal, stratified by sex. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Rutgers Camden Students enrolled in Psych 101 and Method and Theory
- Between the ages of 18-35
Key exclusion criteria (1 listed)
- Students under 18 years of age or over 36 or older will be excluded.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Emotional AppealParticipants will be presented with a short vignette about a child undergoing cancer treatment and needing a bone marrow transplant in order to survive cancer. | Behavioural | Emotional Group |
| Rational AppealParticipants will be presented with data regarding the importance of considering race/ethnicity when looking for a bone marrow transplant donor and the likelihood of finding a match based on the patient's racial/ethnic background. | Behavioural | Rational Group |
Primary outcome
Intention to Register
Time frame: Baseline and after the experimental manipulation (Post-Intervention)
Participants rated the likelihood of registering on a 1-7 scale with higher scores indicating greater intention to join the registry (better outcome). Participants were asked these questions before (baseline) and after (post-intervention) the experimental manipulation.
2 secondary outcomes
Mood
Time frame: Baseline and after experimental manipulation (Post-Intervention)
Psychosocial and Demographic Correlates of Intentions to Register--Knowledge
Time frame: Baseline
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Apr 2025.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Background: PubMed 29069088Billen A, Madrigal JA, Scior K, Shaw BE, Strydom A. Donation of peripheral blood stem cells to unrelated strangers: A thematic analysis. PLoS One. 2017 Oct 25;12(10):e0186438. doi: 10.1371/journal.pone.0186438. eCollection 2017.
- Background: PubMed 8461479Butterworth VA, Simmons RG, Bartsch G, Randall B, Schimmel M, Stroncek DF. Psychosocial effects of unrelated bone marrow donation: experiences of the National Marrow Donor Program. Blood. 1993 Apr 1;81(7):1947-59.
- Background: PubMed 13813058CROWNE DP, MARLOWE D. A new scale of social desirability independent of psychopathology. J Consult Psychol. 1960 Aug;24:349-54. doi: 10.1037/h0047358. No abstract available.
- Background: PubMed 28944484Fingrut W, Parmar S, Cuperfain A, Rikhraj K, Charman E, Ptak E, Kahlon M, Graham A, Luong S, Wang YG, Yu J, Arora N, Suppiah R, Li EW, Lee A, Welsh C, Benzaquen M, Thatcher A, Baharmand I, Ladd A, Petraszko T, Allan D, Messner H. The Stem Cell Club: a model for unrelated stem cell donor recruitment. Transfusion. 2017 Dec;57(12):2928-2936. doi: 10.1111/trf.14327. Epub 2017 Sep 24.
- BackgroundGardner, Paul. (1987). Measuring ambivalence to science. Journal of Research in Science Teaching. 24. 241 - 247. 10.1002/tea.3660240305.
- Background: PubMed 25632376Kaster EC, Rogers CR, Jeon KC, Rosen B. Getting to the Heart of Being the Match: A Qualitative Analysis of Bone Marrow Donor Recruitment and Retention Among College Students. Health Educ (Muncie). 2014 Spring;46(1):14-19.
- Background: PubMed 33084098Monaghan M, Yi QL, Green M, Campbell T, Weiss JT, Dibdin N, Mercer D, Elmoazzen H, Allan DS. Factors associated with registrant availability for unrelated adult donor hematopoietic stem cell donation: Analysis of the stem cell registry at Canadian Blood Services. Transfusion. 2021 Jan;61(1):24-28. doi: 10.1111/trf.16129. Epub 2020 Oct 21.
- Background: PubMed 27343721Narayanan P, Wolanskyj A, Ehlers SL, Litzow MR, Patnaik MS, Hogan WJ, Hashmi SK. Medical Students' Knowledge, Familiarity, and Attitudes towards Hematopoietic Stem Cell Donation: Stem Cell Donation Behaviors. Biol Blood Marrow Transplant. 2016 Sep;22(9):1710-1716. doi: 10.1016/j.bbmt.2016.06.014. Epub 2016 Jun 22.
- BackgroundNational Marrow Donor Program (2013). Key Figures and Facts. www.bethematch.com
- Background: PubMed 15686731Onitilo AA, Lin YH, Okonofua EC, Afrin LB, Ariail J, Tilley BC. Race, education, and knowledge of bone marrow registry: indicators of willingness to donate bone marrow among African Americans and Caucasians. Transplant Proc. 2004 Dec;36(10):3212-9. doi: 10.1016/j.transproceed.2004.10.019.
- Background: PubMed 14748861Rose A, Peters N, Shea JA, Armstrong K. Development and testing of the health care system distrust scale. J Gen Intern Med. 2004 Jan;19(1):57-63. doi: 10.1111/j.1525-1497.2004.21146.x.
- BackgroundRosenberg, M. (1965). Rosenberg self-esteem scale. Journal of Religion and Health.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Lauren C Daniel, Ph.D. principal investigator
Rutgers University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Emotional Appeal and Rational Appeal in people with Healthy, run by Rutgers, The State University of New Jersey at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 18 Apr 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Intention to Register (time frame: Baseline and after the experimental manipulation (Post-Intervention)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05595382, which also lists 18 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Apr 2025.