AzTrials
AzTrials

Atherosclerotic Cardiovascular DiseasePhase 3NCT05581303

Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial

A Phase 3 study testing Olpasiran in people with Atherosclerotic Cardiovascular Disease, run by Amgen at 492 sites in 24 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
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Trial summary

The primary objective of this trial is to compare the effect of treatment with olpasiran, to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants with atherosclerotic cardiovascular disease (ASCVD) and elevated Lipoprotein(a). Read more about this study

Who is it for?
Ages 18 to 85 years
Conditions the study is for
Atherosclerotic Cardiovascular Disease
What is being tested?
Olpasiran
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
7,297 participants
Where
492 sitesin 24 countries
Study dates
14 Dec 2022to 31 Mar 2028
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 85 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Age 18 to ≤ 85 years
  • Lp(a) ≥ 200 nmol/L during screening
  • History of ASCVD as evidenced by history of either:
  • Myocardial infarction (presumed type 1 event due to plaque rupture/erosion) and/or
  • Coronary revascularization with percutaneous coronary intervention AND at least 1 additional risk factor.

Who cannot join

  • Severe renal dysfunction
  • Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 x upper limit of normal (ULN), or total bilirubin (TBL) > 2 x ULN during screening
  • History of hemorrhagic stroke
  • History of major bleeding disorder
  • Planned cardiac surgery or arterial revascularization
  • Severe heart failure
  • Current, recent, or planned lipoprotein apheresis
  • Previously received ribonucleic acid therapy specifically targeting Lp(a)

Trial locations and contacts

492 sites in 24 countries.

492 sites in 24 countries

United States122 sites

  • Endeavor Health-Northwest Community Healthcare

    Arlington Heights, Illinois, 60005

  • Asheville Cardiology Associates

    Asheville, North Carolina, 28801

  • Piedmont Healthcare

    Atlanta, Georgia, 30309

  • Morehouse School of Medicine

    Atlanta, Georgia, 30310

  • Texas Diabetes and Endocrinology

    Austin, Texas, 78731

  • University of Maryland Medical Center

    Baltimore, Maryland, 21201

  • Ascension Saint Agnes Heart Care

    Baltimore, Maryland, 21229

  • Johns Hopkins University

    Baltimore, Maryland, 21287

  • Northern Light Eastern Maine Medical Center

    Bangor, Maine, 04401

  • Metropolitan Cardiovascular Consultants LLC

    Beltsville, Maryland, 20705

  • National Heart Institute

    Beverly Hills, California, 90211

  • Pacific Oaks Medical Group

    Beverly Hills, California, 90211

  • University of Alabama Saint Vincent's Birmingham

    Birmingham, Alabama, 35205

  • Grandview Medical Center Affinity Cardiovascular Specialists, LLC

    Birmingham, Alabama, 35243

  • Brigham and Womens Hospital

    Boston, Massachusetts, 02215

  • Bay Area Cardiology

    Brandon, Florida, 33511

  • Medical University of South Carolina

    Charleston, South Carolina, 29425

  • Novant Health Heart and Vascular Institute

    Charlotte, North Carolina, 28204

  • TriHealth Good Samaritan Hospital

    Cincinnati, Ohio, 45220

  • Clearwater Cardiovascular Consultants

    Clearwater, Florida, 33756

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106

  • UCHealth Memorial Central

    Colorado Springs, Colorado, 80909

  • Prisma Health Midlands Cardiology

    Columbia, South Carolina, 29203

  • The OhioHealth Research Institute

    Columbus, Ohio, 43210

  • Saint Elizabeth Covington

    Covington, Kentucky, 41011

  • Louisiana Heart Center

    Covington, Louisiana, 70433

  • Northeast Georgia Medical Center Wisteria Building

    Cumming, Georgia, 30041

  • Baylor Scott and White Heart and Vascular Hospital-Dallas

    Dallas, Texas, 75226

  • Southwest Family Medicine Associates

    Dallas, Texas, 75247

  • Cardiology Associates Research LLC

    Daytona Beach, Florida, 32117

  • Henry Ford Health System

    Detroit, Michigan, 48202

  • Duke University

    Durham, North Carolina, 27710

  • David Turbay, MD

    El Paso, Texas, 79905

  • Endeavor Health Skokie Hospital

    Evanston, Illinois, 60201

  • Inova Heart and Vascular Institute

    Fairfax, Virginia, 22031

  • Virginia Heart - Loudoun

    Falls Church, Virginia, 22042

  • Lillestol Research LLC

    Fargo, North Dakota, 58104

  • Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care

    Fort Lauderdale, Florida, 33312

  • Piedmont Research Partners

    Fort Mill, South Carolina, 29707

  • Stern Cardiovascular Foundation Inc

    Germantown, Tennessee, 38138

  • Moses H Cone Memorial Hospital

    Greensboro, North Carolina, 27401

  • Elite Cardiac Research Center LLC

    Hialeah, Florida, 33013

  • Baylor College of Medicine

    Houston, Texas, 77030

  • Huntsville Clinical Research, LLC

    Huntsville, Alabama, 35801

  • East Coast Institute for Research, LLC

    Jacksonville, Florida, 32204

  • Westside Center for Clinical Research

    Jacksonville, Florida, 32205

  • University of Florida

    Jacksonville, Florida, 32209

  • East Coast Institute for Research LLC

    Jacksonville, Florida, 32216

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216

  • Nsc Research

    Johns Creek, Georgia, 30024

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160

  • Kettering Medical Center

    Kettering, Ohio, 45429

  • Texas Cardiology Associates of Houston

    Kingwood, Texas, 77339

  • University of California San Diego

    La Jolla, California, 92037

  • Sparrow Clinical Research Institute

    Lansing, Michigan, 48912

  • Palm Research Center Inc

    Las Vegas, Nevada, 89148

  • Virginia Heart

    Leesburg, Virginia, 20176

  • The Research Group of Lexington LLC

    Lexington, Kentucky, 40503

  • Bryan Heart

    Lincoln, Nebraska, 68506

  • VA Greater Los Angeles Healthcare System

    Los Angeles, California, 90073

  • Carient Heart and Vascular

    Manassas, Virginia, 20109

  • Northwell Health Physician Partners Cardiology at Manhasset

    Manhasset, New York, 11030

  • Fairview Health Services M Health Fairview St Johns Hospital

    Maplewood, Minnesota, 55109

  • Rama Research LLC

    Marion, Ohio, 43302

  • Texas Institute of Cardiology

    McKinney, Texas, 75071

  • St Lukes Idaho

    Meridian, Idaho, 83642

  • Excel Medical Clinical Trials

    Miami, Florida, 33135

  • Bon Secours Cardiology

    Midlothian, Virginia, 23114

  • Minneapolis Heart Institute Foundation

    Minneapolis, Minnesota, 55407

  • University of Minnesota

    Minneapolis, Minnesota, 55455

  • Mobile Heart Specialists PC

    Mobile, Alabama, 36608

  • Clinical Trials of America Inc

    Monroe, Louisiana, 71201

  • Cardiovascular Research of Northwest Indiana LLC

    Munster, Indiana, 46321

  • Advanced Research for Health Improvement, LLC

    Naples, Florida, 34102

  • New York University Grossman School of Medicine and New York University Langone Hospitals

    New York, New York, 10016

  • Northwell Health Lenox Hill Heart and Vascular

    New York, New York, 10022

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029

  • Saint Michaels Medical Center

    Newark, New Jersey, 07102

  • Capital Area Research LLC

    Newport, Pennsylvania, 17074

  • Tidewater Physicians Multispecialty Group Clinical Research

    Newport News, Virginia, 23606

  • Ocala Cardiovascular Research

    Ocala, Florida, 34471

  • Permian Research Foundation

    Odessa, Texas, 79761

  • University of California Irvine

    Orange, California, 92868

  • AdventHealth Medical Group Cardiology at Orlando

    Orlando, Florida, 32803

  • Midwest Heart and Vascular Specialists

    Overland Park, Kansas, 66211

  • Advocate Lutheran General Hospital

    Park Ridge, Illinois, 60068

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104

  • Montefiore Medical Center - Bronx

    Philadelphia, Pennsylvania, 19141

  • HonorHealth Research and Innovation Institute

    Phoenix, Arizona, 85006

  • Elite Clinical Studies LLC

    Phoenix, Arizona, 85018

  • Allegheny General Hospital

    Pittsburgh, Pennsylvania, 15212

  • Oregon Health and Science University

    Portland, Oregon, 97239

  • Pulse Heart Institute

    Puyallup, Washington, 98372

  • Monument Health Clinical Research

    Rapid City, South Dakota, 57701

  • Renown Institute for Heart and Vascular Health

    Reno, Nevada, 89502

  • Reid Physician Associates

    Richmond, Indiana, 47374

  • Northwell Health Physician Partners at Peconic

    Riverhead, New York, 11901

  • Mayo Clinic

    Rochester, Minnesota, 55905

  • Advanced Cardiology Associates

    Rochester Hills, Michigan, 48307

  • Healthy Heart Cardiology

    Rochester Hills, Michigan, 48307

  • East Coast Institute for Research, LLC

    Saint Augustine, Florida, 32086

  • Saint Johns Center for Clinical Research

    Saint Augustine, Florida, 32086

  • TidalHealth Peninsula Regional, Inc

    Salisbury, Maryland, 21804

  • University of California Los Angeles

    Santa Monica, California, 90404

  • Cardiovascular Center of Sarasota

    Sarasota, Florida, 34239

  • Saint Louis Heart and Vascular PC

    St Louis, Missouri, 63136

  • Cardiology Associates of Fairfield County PC

    Stamford, Connecticut, 06905

  • Manshadi Heart Institute

    Stockton, California, 95204

  • Stony Brook University Hospital

    Stony Brook, New York, 11794

  • Overlook Medical Center

    Summit, New Jersey, 07901

  • Med Partners, Inc dba Premiere Medical Center, Inc

    Toluca Lake, California, 91602

  • Northwest Houston Heart Center

    Tomball, Texas, 77375

  • Arcturus Healthcare, Public Limited Company, Troy Internal Medicine Research Division

    Troy, Michigan, 48098

  • Tennessee Center for Clinical Trials

    Tullahoma, Tennessee, 37388

  • Cardiology Associates Research LLC

    Tupelo, Mississippi, 38801

  • WMCHealth Heart and Vascular Institute Kingston Division of Cardiology

    Valhalla, New York, 10595

  • MedStar Clinical Research

    Washington D.C., District of Columbia, 20010

  • MercyOne Iowa Heart Center

    West Des Moines, Iowa, 50266

  • Monroe Research LLC

    West Monroe, Louisiana, 71291

  • Winchester Cardiology and Vascular Medicine

    Winchester, Virginia, 22601

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157

  • White Plains Hospital Physician Associates - Hudson Valley Cardiovascular Group

    Yorktown Heights, New York, 10598

Other trials in United States

Japan59 sites

  • Ageo Central General Hospital

    Ageo-shi, Saitama, 362-8588

  • Asahi General Hospital

    Asahi-shi, Chiba, 289-2511

  • Asahikawa City Hospital

    Asahikawa-shi, Hokkaido, 070-8610

  • Juntendo University Hospital

    Bunkyo-ku, Tokyo, 113-8431

  • University of Yamanashi Hospital

    Chuo-shi, Yamanashi, 409-3898

  • Fujisawa City Hospital

    Fujisawa-shi, Kanagawa, 251-8550

  • Fukuoka University Hospital

    Fukuoka, Fukuoka, 814-0180

  • Gifu Heart Center

    Gifu, Gifu, 500-8384

  • Medical Corporation Kenshinkai Minamino Cardiovascular Hospital

    Hachioji-shi, Tokyo, 192-0918

  • Hakodate Municipal Hospital

    Hakodate-shi, Hokkaido, 041-8680

  • Hyogo Prefectural Harima-Himeji General Medical Center

    Himeji-shi, Hyōgo, 670-8560

  • Hirosaki University Hospital

    Hirosaki-shi, Aomori, 036-8563

  • Hiroshima City Hiroshima Citizens Hospital

    Hiroshima, Hiroshima, 730-8518

  • Tokai University Hospital

    Isehara-shi, Kanagawa, 259-1193

  • Rinku General Medical Center

    Izumisano, Osaka, 598-8577

  • Kagoshima City Hospital

    Kagoshima, Kagoshima-ken, 890-8760

  • Tenyoukai Central Clinic

    Kagoshima, Kagoshima-ken, 892-0822

  • Kanazawa Medical University Hospital

    Kahoku-gun, Ishikawa-ken, 920-0293

  • Kanazawa University Hospital

    Kanazawa, Ishikawa-ken, 920-8641

  • Kasugai Municipal Hospital

    Kasugai-shi, Aichi-ken, 486-8510

  • Kokura Memorial Hospital

    Kitakyushu-shi, Fukuoka, 802-8555

  • Japan Community Health care Organization Kyushu Hospital

    Kitakyushu-shi, Fukuoka, 806-8501

  • Kobe City Medical Center General Hospital

    Kobe, Hyōgo, 650-0047

  • Chikamori Hospital

    Kochi, Kochi, 780-8522

  • Saiseikai Kumamoto Hospital

    Kumamoto, Kumamoto, 861-4193

  • Kawasaki Medical School Hospital

    Kurashiki-shi, Okayama-ken, 701-0192

  • New Tokyo Heart Clinic

    Matsudo-shi, Chiba, 271-0077

  • Shinshu University Hospital

    Matsumoto-shi, Nagano, 390-8621

  • National Hospital Organization Tokyo Medical Center

    Meguro-ku, Tokyo, 152-8902

  • Miyazaki Medical Association Hospital

    Miyazaki, Miyazaki, 880-2102

  • Iwate Prefectural Central Hospital

    Morioka, Iwate, 020-0066

  • Japanese Red Cross Musashino Hospital

    Musashino-shi, Tokyo, 180-8610

  • Nagoya University Hospital

    Nagoya, Aichi-ken, 466-8560

  • Niigata University Medical and Dental Hospital

    Niigata, Niigata, 951-8520

  • Ome Medical Center

    Ome-shi, Tokyo, 198-0042

  • Sakurabashi Watanabe Advanced Healthcare Hospital

    Osaka, Osaka, 530-0005

  • Osaka City General Hospital

    Osaka, Osaka, 534-0021

  • Osaka Keisatsu Hospital

    Osaka, Osaka, 543-0042

  • Osaka Metropolitan University Hospital

    Osaka, Osaka, 545-8586

  • Osaka General Medical Center

    Osaka, Osaka, 558-8558

  • Saga-ken Medical Centre Koseikan

    Saga, Saga-ken, 840-8571

  • Kitasato University Hospital

    Sagamihara-shi, Kanagawa, 252-0375

  • Sanai Hospital

    Saitama-shi, Saitama, 338-0837

  • Tohoku University Hospital

    Sendai, Miyagi, 980-8574

  • Sendai Cardiovascular Center

    Sendai, Miyagi, 981-3133

  • Tosei General Hospital

    Seto-shi, Aichi-ken, 489-8642

  • Tokyo Womens Medical University Hospital

    Shinjuku-ku, Tokyo, 162-8666

  • Tokuyama Central Hospital

    Shunan-shi, Yamaguchi, 745-8522

  • National Hospital Organization Shizuoka Medical Center

    Sunto-gun, Shizuoka, 411-8611

  • Takamatsu Red Cross Hospital

    Takamatsu, Kagawa-ken, 760-0017

  • Kagawa Prefectural Central Hospital

    Takamatsu, Kagawa-ken, 760-8557

  • Tomakomai City Hospital

    Tomakomai-shi, Hokkaido, 053-8567

  • Fujita Health University Hospital

    Toyoake-shi, Aichi-ken, 470-1192

  • Seiyu Memorial Hospital

    Wakayama, Wakayama, 649-6335

  • Showa Medical University Fujigaoka Hospital

    Yokohama, Kanagawa, 227-8501

  • Yokohama City University Medical Center

    Yokohama, Kanagawa, 232-0024

  • Yokohama Minami Kyousai Hospital

    Yokohama, Kanagawa, 236-0037

  • Yokohama Sakae Kyosai Hospital Federation of National Public Service Personnel Mutual Association

    Yokohama, Kanagawa, 247-8581

  • University of Fukui Hospital

    Yoshida-gun, Fukui, 910-1193

Other trials in Japan

Brazil39 sites

  • jmf Clinica do Coracao ltda

    Aracaju, Sergipe, 49055-530

  • AngioCor Blumenau

    Blumenau, Santa Catarina, 89020-430

  • Assoc Amparo Saude Ensin e Pesquisa

    Brasília, Federal District, 71625-175

  • Instituto de Pesquisa Clínica de Campinas

    Campinas, São Paulo, 13060-080

  • Loema Instituto de Pesquisa Clinica e Consultores Ltda - Clinica Loema

    Campinas, São Paulo, 13092-133

  • Hospital Universitario Maria Aparecida Pedrossian

    Campo Grande, Mato Grosso do Sul, 79080-190

  • Quanta Diagnostico por Imagem

    Curitiba, Paraná, 80045-170

  • Nucleo de Pesquisa Clinica

    Curitiba, Paraná, 80730-150

  • Hospital Universitario Walter Cantidio - Universidade Federal do Ceara

    Fortaleza, Ceará, 60430-270

  • Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas

    Fortaleza, Ceará, 60430-350

  • Hospital das Clinicas da Universidade Federal de Goias

    Goiânia, Goiás, 74605-020

  • icm Instituto do Coração de Marilia

    Marília, São Paulo, 17515-000

  • Instituto Atena de Pesquisa Clínica

    Natal, Rio Grande do Norte, 59020-500

  • Hospital Sao Francisco da Santa Casa de Misericordia de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90020-090

  • Associação Hospitalar Moinhos de Vento

    Porto Alegre, Rio Grande do Sul, 90035-001

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90410-000

  • Nucleo de Pesquisa Clinica do Rio Grande do Sul

    Porto Alegre, Rio Grande do Sul, 90430-001

  • Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul

    Porto Alegre, Rio Grande do Sul, 90610-000

  • Instituto de Cardiologia do Rio Grande do Sul

    Porto Alegre, Rio Grande do Sul, 90620-001

  • Imv Pesquisa Cardiologica Sociedade Simples Coracentro

    Porto Alegre, Rio Grande do Sul, 90840-440

  • FZ Pesquisa e Servicos em Cardiologia LTDA

    Porto Alegre, Rio Grande do Sul, 91350-280

  • Procape

    Recife, Pernambuco, 50100-060

  • Hospital Agamenon Magalhaes

    Recife, Pernambuco, 52051-380

  • Clinicor Clinica Cardiologica

    Ribeirão Preto, São Paulo, 14026-900

  • Hospital Das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo

    Ribeirão Preto, São Paulo, 14051-140

  • IBPClin Instituto Brasil de Pesquisa Clinica

    Rio de Janeiro, Rio de Janeiro, 20241-180

  • Fundacao Pro-Coracao

    Rio de Janeiro, Rio de Janeiro, 22240-006

  • Hospital Santa Izabel

    Salvador, Estado de Bahia, 40050-410

  • Hospital Ana Nery

    Salvador, Estado de Bahia, 40301-155

  • Instituto de Ensino e Pesquisa do Hospital da Bahia

    Salvador, Estado de Bahia, 41810-011

  • Hospital de Base de Sao Jose do Rio Preto

    São José do Rio Preto, São Paulo, 15090-000

  • Instituto de Pesquisa em Endocrinologia Clinica IPEC

    São Paulo, São Paulo, 01223-001

  • Sociedade Beneficente de Senhoras Hospital Sirio Libanes

    São Paulo, São Paulo, 01308-050

  • Instituto Dante Pazzanese de Cardiologia

    São Paulo, São Paulo, 04012-909

  • Centro Paulista de Investigacao Clinica Cepic

    São Paulo, São Paulo, 04266-010

  • Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo

    São Paulo, São Paulo, 05403-000

  • Eurolatino Pesquisas Medicas

    Uberlândia, Minas Gerais, 38400-500

  • Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo

    Vitória, Espírito Santo, 29055-450

  • Integral Pesquisa e Ensino

    Votuporanga, São Paulo, 15501-405

Other trials in Brazil

China39 sites

  • Beijing Friendship Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100050

  • Peking University Third Hospital

    Beijing, Beijing Municipality, 100191

  • Beijing Hospital

    Beijing, Beijing Municipality, 100730

  • The First Bethune Hospital of Jilin University

    Changchun, Jilin, 130021

  • China Japan Union Hospital of Jilin University

    Changchun, Jilin, 130033

  • The Second Xiangya Hospital of Central South University

    Changsha, Hunan, 410011

  • The Third Xiangya Hospital of Central South University

    Changsha, Hunan, 410013

  • West China Hospital Sichuan University

    Chengdu, Sichuan, 610041

  • Daqing Oilfield general Hospital

    Daqing, Heilongjiang, 163000

  • Sun Yat-sen Memorial Hospital Sun Yat-sen University

    Guangzhou, Guangdong, 510120

  • Nanfang Hospital Southern Medical University

    Guangzhou, Guangdong, 510515

  • Guangdong Provincial Peoples Hospital

    Guangzhou, Guangdong, 519041

  • Zhejiang Hospital

    Hangzhou, Zhejiang, 310000

  • Zhejiang Provincial Peoples Hospital

    Hangzhou, Zhejiang, 310014

  • The First Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, 150001

  • Huizhou Central Peoples Hospital

    Huizhou, Guangdong, 516001

  • Jinan Central Hospital

    Jinan, Shandong, 250013

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006

  • Nanjing First Hospital

    Nanjing, Jiangsu, 210000

  • Nanjing Drum Tower Hospital

    Nanjing, Jiangsu, 210008

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, Jiangsu, 210011

  • Zhongda Hospital Southeast University

    Nanjing, Jiangsu, 210011

  • The Peoples Hospital of Guangxi Zhuang Autonomous Region

    Nanning, Guangxi, 530021

  • The Second Nanning Peoples Hospital

    Nanning, Guangxi, 530031

  • Nanyang Second General Hospital

    Nanyang, Henan, 473009

  • Qingdao Fuwai Cardiovascular Hospital

    Qingdao, Shandong, 266011

  • Shanghai General Hospital

    Shanghai, Shanghai Municipality, 200080

  • Shanghai Yangpu District Central Hospital（ Yangpu Hospital Affiliated to Tongji University）

    Shanghai, Shanghai Municipality, 200080

  • The First Affiliated Hospital of Soochow University

    Suzhou, Jiangsu, 215006

  • Tianjin Medical University General Hospital

    Tianjin, Tianjin Municipality, 300052

  • Tianjin Peoples Hospital

    Tianjin, Tianjin Municipality, 300120

  • Tianjin Chest Hospital

    Tianjin, Tianjin Municipality, 300222

  • The First Affiliated Hospital of Xinjiang Medical University

    Ürümqi, Xinjiang, 830054

  • Renmin Hospital of Wuhan University

    Wuhan, Hubei, 430060

  • Wuxi Peoples Hospital

    Wuxi, Jiangsu, 214023

  • Shaanxi Provincial Peoples Hospital

    Xi'an, Shaanxi, 710068

  • Xiangtan Central Hospital

    Xiangtan, Hunan, 411100

  • The Affiliated Hospital of Xuzhou Medical University

    Xuzhou, Jiangsu, 221006

  • General Hospital of Ningxia Medical University

    Yinchuan, Ningxia, 750004

Other trials in China

Germany29 sites

  • Universitaetsklinikum Aachen

    Aachen, 52074

  • Universitaets-Herzzentrum Freiburg - Bad Krozingen

    Bad Krozingen, 79189

  • Universitaetsklinikum der Ruhr-Universitaet Bochum

    Bad Oeynhausen, 32545

  • Velocity Clinical Research GmbH

    Berlin, 10787

  • Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin

    Berlin, 12203

  • Charite - Universitaetsmedizin Berlin, Campus Virchow

    Berlin, 13353

  • Klinikum Links der Weser

    Bremen, 28277

  • Universitaetsklinikum Koeln

    Cologne, 50937

  • Universitaetsklinikum Dresden

    Dresden, 01307

  • Universitaetsklinikum Essen

    Essen, 45147

  • Universitaetsklinikum Frankfurt

    Frankfurt am Main, 60590

  • ClinPhenomics CVC GmbH

    Frankfurt am Main, 60596

  • Evangelisches Krankenhaus Goettingen-Weende

    Göttingen, 37075

  • Universitaetsklinikum Hamburg-Eppendorf

    Hamburg, 20251

  • Cardiologicum Hamburg GbR

    Hamburg, 22041

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69120

  • Braun Ambulantes Herzzentrum Kassel

    Kassel, 34121

  • Universitaetsklinikum Leipzig

    Leipzig, 04103

  • Otto von Guericke Universitaet Magdeburg

    Magdeburg, 39120

  • Universitaetsklinikum Mannheim

    Mannheim, 68167

  • Kardiologische Praxis Doktor Jens Taggeselle

    Markkleeberg, 04416

  • Klinikum rechts der Isar der TUM

    München, 80636

  • Universitaetsklinikum Muenster

    Münster, 48149

  • Kardiologische Gemeinschaftspraxis Papenburg

    Papenburg, 26871

  • Sana-Klinikum Remscheid GmbH

    Remscheid, 42859

  • Lipidambulanz der Universitaet Rostock

    Rostock, 18057

  • Klinik am See - Ruedersdorf

    Rüdersdorf, 15562

  • Hegau-Bodensee-Klinikum Singen

    Singen, 78224

  • Forschungszentrum Ruhr

    Witten, 58455

Other trials in Germany

Poland24 sites

  • American Heart of Poland Spolka Akcyjna

    Bełchatów, 97-400

  • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca

    Bielsko-Biala, 43-316

  • American Heart of Poland Spolka Akcyjna

    Chrzanów, 32-500

  • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca

    Dąbrowa Górnicza, 41-300

  • Velocity Nova Sp zoo Velocity Zamosc

    Dębica, 39-200

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80-214

  • Niepubliczny Zaklad Opieki Zdrowotnej Medica Jerzy Cygler

    Giżycko, 11-500

  • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca

    Kędzierzyn-Koźle, 47-200

  • Jaroslaw Ciosek Rajtar-Medica Centrum Medyczne

    Krakow, 31-514

  • Wojewodzki Specjalistyczny Szpital im dr Wladyslawa Bieganskiego w Lodzi

    Lodz, 91-347

  • Miedziowe Centrum Zdrowia SA

    Lubin, 59-301

  • Clinical Best Solutions Sp zoo Spolka Komandytowa Gabinet Lekarski

    Lublin, 20-011

  • CenterMed Spzoo Centermed Lublin

    Lublin, 20-044

  • NZOZ Twoja Przychodnia Spzoo Twoja Przychodnia Spzoo

    Lublin, 20-857

  • Uniwersyteckie Centrum Stomatologii I Medycyny Specjalistycznej Spzoo

    Poznan, 60-354

  • Velocity Nova Sp zoo Velocity Pulawy

    Puławy, 24-100

  • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca

    Sztum, 82-400

  • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca

    Tychy, 43-100

  • Futuremeds Spolka z ograniczona odpowiedzialnoscia

    Warsaw, 00-215

  • Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo

    Warsaw, 04-073

  • Narodowy Instytut Kardiologii Stefana kardynala Wyszynskiego - Panstwowy Instytut Badawczy

    Warsaw, 04-628

  • Futuremeds spolka z ograniczona odpowiedzialnoscia

    Wroclaw, 53-673

  • Slaskie Centrum Chorob Serca w Zabrzu

    Zabrze, 41-800

  • American Heart of Poland Spolka Akcyjna

    Zgierz, 95-100

Other trials in Poland

Spain22 sites

  • Complexo Hospitalario Universitario A Coruña

    A Coruña, Galicia, 15006

  • Hospital Universitari Germans Trias i Pujol

    Badalona, 08916

  • Hospital del Mar

    Barcelona, Catalonia, 08003

  • Hospital Universitari Vall d Hebron

    Barcelona, Catalonia, 08035

  • Hospital Clinic i Provincial de Barcelona

    Barcelona, Catalonia, 08036

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Catalonia, 08041

  • Hospital Universitario Reina Sofia

    Córdoba, Andalusia, 14004

  • Hospital Universitario Virgen de la Arrixaca

    El Palmar, Murcia, 30120

  • Hospital de Cabueñes

    Gijón, Principality of Asturias, 33394

  • Hospital Universitari de Bellvitge

    L'Hospitalet de Llobregat, Catalonia, 08907

  • Hospital Universitario de Leon

    León, Castille and León, 24071

  • Hospital Universitario Ramon y Cajal

    Madrid, Madrid, 28023

  • Hospital Clinico San Carlos

    Madrid, Madrid, 28040

  • Hospital Universitario 12 de Octubre

    Madrid, Madrid, 28041

  • Hospital Clinico Universitario Virgen de la Victoria

    Málaga, Andalusia, 29010

  • Hospital de Sant Joan Despi Moises Broggi

    Sant Joan Despí, Catalonia, 08970

  • Hospital Universitario Virgen Macarena

    Seville, Andalusia, 41009

  • Hospital Universitario Virgen del Rocio

    Seville, Andalusia, 41013

  • Hospital Clinico Universitario de Valencia

    Valencia, Valencia, 46010

  • Hospital Arnau de Vilanova de Valencia

    Valencia, Valencia, 46015

  • Hospital Alvaro Cunqueiro

    Vigo, Galicia, 36312

  • Hospital Universitario Miguel Servet

    Zaragoza, Aragon, 50009

Other trials in Spain

Australia20 sites

  • Nightingale Research

    Adelaide, SAU, 5000

  • Advara HeartCare Wesley

    Auchenflower, Queensland, 4066

  • Flinders Medical Centre

    Bedford Park, SAU, 5042

  • Royal Prince Alfred Hospital

    Camperdown, New South Wales, 2050

  • Victorian Heart Hospital

    Clayton, Victoria, 3168

  • Concord Repatriation General Hospital

    Concord, New South Wales, 2139

  • The Cardiologists Proprietary Limited

    Epping, Victoria, 3076

  • Canberra Hospital

    Garran, Australian Capital Territory, 2605

  • Barwon Health Geelong Hospital

    Geelong, Victoria, 3220

  • Royal Brisbane and Womens Hospital

    Herston, Queensland, 4029

  • Royal Hobart Hospital

    Hobart, Tasmania, 7000

  • Advara HeartCare Joondalup

    Joondalup, WST, 6027

  • Advara HeartCare Leabrook

    Leabrook, SAU, 5068

  • Liverpool Hospital

    Liverpool, New South Wales, 2170

  • Core Research Group Pty Ltd

    Milton, Queensland, 4064

  • Linear Clinical Research Limited

    Nedlands, WST, 6009

  • Clinitrials - West Perth

    Perth, Western Australia, 6000

  • Momentum Clinical Research - Darlinghurst

    Sydney, New South Wales, 2010

  • Wollongong Hospital

    Wollongong, New South Wales, 2500

  • Dr Heart Pty Ltd

    Woolloongabba, Queensland, 4102

Other trials in Australia

France19 sites

  • Centre Hospitalier Regional Universitaire de Besancon - Hopital Jean Minjoz

    Besançon, 25030

  • Hospices Civils de Lyon Groupement Hospitalier Est - Hopital Louis Pradel

    Bron, 69677

  • Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau

    Chambray-lès-Tours, 37170

  • Centre Hospitalier Compiegne-Noyon

    Compiègne, 60200

  • Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand

    Dijon, 21079

  • Centre Hospitalier Regional Universitaire de Lille - Hopital Claude Huriez

    Lille, 59037

  • Hopital de la Conception

    Marseille, 13005

  • Hopital Saint-Joseph

    Marseille, 13285

  • Centre Hospitalier Universitaire de Montpellier - Hopital Lapeyronie

    Montpellier, 34090

  • Centre Hospitalier Universitaire de Nantes - Hopital Nord Laennec

    Nantes, 44800

  • Centre Hospitalier Universitaire de Nice - Hopital Pasteur

    Nice, 06000

  • Hopital Saint Antoine

    Paris, 75012

  • Hopital Pitie-Salpetriere

    Paris, 75013

  • Hopital Bichat Claude Bernard

    Paris, 75877

  • Centre Hospitalier Universitaire de Reims - Hopital Robert Debre

    Reims, 51092

  • Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou

    Rennes, 35033

  • Centre Hospitalier Universitaire de Strasbourg - Hopital de Hautepierre

    Strasbourg, 67000

  • Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil

    Toulouse, 31059

  • Polyclinique Vauban

    Valenciennes, 59300

Other trials in France

Italy18 sites

  • Ospedali dell Ovest Vicentino

    Arzignano, 36071

  • IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant Orsola

    Bologna, 40138

  • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

    Brescia, 25123

  • Azienda Ospedaliera Sant Anna e San Sebastiano

    Caserta, 81100

  • Azienda Ospedaliera Universitaria Renato Dulbecco

    Catanzaro, 88100

  • Azienda Ospedaliera Universitaria di Ferrara Arcispedale Sant Anna

    Cona FE, 44124

  • Azienda Ospedaliero Universitaria Careggi

    Florence, 50139

  • IRCCS Centro Cardiologico Monzino

    Milan, 20138

  • Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

    Milan, 20162

  • Azienda Ospedaliera Universitaria Federico II

    Naples, 80131

  • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

    Palermo, 90127

  • ASL TO3 Ospedale di Rivoli

    Rivoli, 10098

  • Azienda Ospedaliera Universitaria Policlinico Tor Vergata

    Roma, 00133

  • Azienda Ospedaliera Policlinico Umberto I

    Roma, 00161

  • IRCCS Istituto Clinico Humanitas

    Rozzano, 20089

  • Azienda Ospedaliera Universitaria Ospedale San Giovanni di Dio e Ruggi D Aragona

    Salerno, 84131

  • Multimedica

    Sesto San Giovanni (MI), 20099

  • Azienda Ospedaliera Ordine Mauriziano di Torino

    Torino, 10128

Other trials in Italy

Hungary16 sites

  • Lausmed Kft

    Baja, 6500

  • Dr Lakatos Ferenc Private Cardiology Practice

    Békéscsaba, 5600

  • Budapesti Szent Ferenc Korhaz

    Budapest, 1021

  • High Tech Medical Kft

    Budapest, 1027

  • Gottsegen Gyorgy Orszagos Kardiovaszkularis Intezet

    Budapest, 1096

  • Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika

    Budapest, 1122

  • Eszak-Pesti Centrum Korhaz - Honvedkorhaz

    Budapest, 1134

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032

  • Pharma4 Trial Kft

    Gyöngyös, 3200

  • BKS Research Kft

    Hatvan, 3000

  • Komaromi Selye Janos Korhaz

    Komárom, 2921

  • Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz

    Miskolc, 3526

  • Vita Verum Medical Bt

    Székesfehérvár, 8000

  • Dr Nagy Laszlo Kardiologiai maganrendeles es SMO

    Szentes, 6600

  • Belvarosi Egeszseghaz Kft

    Zalaegerszeg, 8900

  • Obudai Egeszsegugyi Centrum Kft

    Zalaegerszeg, 8900

Other trials in Hungary

South Korea13 sites

  • Dong-A University Hospital

    Busan, 49201

  • Chonnam National University Hospital

    Gwangju, 61469

  • Gachon University Gil Medical Center

    Incheon, 21565

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620

  • Korea University Anam Hospital

    Seoul, 02841

  • Seoul National University Hospital

    Seoul, 03080

  • Kangbuk Samsung Hospital

    Seoul, 03181

  • Asan Medical Center

    Seoul, 05505

  • Samsung Medical Center

    Seoul, 06351

  • The Catholic University of Korea Seoul St Marys Hospital

    Seoul, 06591

  • Korea University Guro Hospital

    Seoul, 08308

  • Ulsan University Hospital

    Ulsan, 44033

  • Yonsei University Wonju Severance Christian Hospital

    Wonju-si, Gangwon-do, 26426

Other trials in South Korea

Greece12 sites

  • General Hospital of Athens Evaggelismos

    Athens, 10676

  • Athens Naval Hospital

    Athens, 11521

  • General Hospital of Athens Ippokrateio

    Athens, 11527

  • Laiko General Hospital of Athens

    Athens, 11527

  • Alexandra Hospital

    Athens, 11528

  • Attikon Hospital

    Athens, 12462

  • Konstantopoulio - Agia Olga Hospital of Nea Ionia

    Athens, 14233

  • Hygeia Hospital

    Athens, 15123

  • Metropolitan Hospital

    Athens, 18547

  • University Hospital of Heraklion

    Heraklion, 71500

  • University Hospital of Ioannina

    Ioannina, 45500

  • General Hospital of Thessaloniki Ahepa

    Thessaloniki, 54636

Other trials in Greece

Austria11 sites

  • Landeskrankenhaus Feldkirch

    Feldkirch, 6800

  • Medizinische Universitaet Graz

    Graz, 8036

  • Klinikum Klagenfurt am Woerthersee

    Klagenfurt, 9020

  • Krankenhaus der Barmherzigen Brueder Linz

    Linz, 4021

  • Landeskrankenhaus Salzburg

    Salzburg, 5020

  • Universitaetsklinikum Sankt Poelten

    Sankt Pölten, 3100

  • Klinik Landstrasse

    Vienna, 1030

  • Universitaetsklinikum Allgemeines Krankenhaus Wien

    Vienna, 1090

  • Klinik Hietzing

    Vienna, 1130

  • Klinik Ottakring

    Vienna, 1160

  • Krankenhaus Nord - Klinik Floridsdorf

    Vienna, 1210

Other trials in Austria

Bulgaria10 sites

  • Multiprofile Hospital for Active Treatment Puls AD

    Blagoevgrad, 2700

  • Medical Center Medconsult Pleven OOD

    Pleven, 5800

  • Multiprofile Hospital for Active Treatment Heart and Brain EAD

    Pleven, 5804

  • Medical Center Cardiomed 2020 EOOD

    Sliven, 8800

  • Multiprofile Hospital for Active Treatment National Hospital of Cardiology EAD

    Sofia, 1309

  • Acibadem City Clinic University Multiprofile Hospital for Active Treatment EOOD-Third clinical base

    Sofia, 1407

  • Medical Center Kalimat EOOD

    Sofia, 1756

  • Medical Center Medicabilis EOOD

    Sofia, 1784

  • Medical Center Orpheus OOD

    Stara Zagora, 6000

  • Ambulatory for Individual Practice for Specialized Medical Care - Kardio EOOD

    Varna, 9020

Other trials in Bulgaria

Taiwan9 sites

  • Hualien Tzu Chi Hospital

    Hualien City, Hualien, 97002

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, Kaohsiung, 80756

  • Mackay Memorial Hospital Tamsui Branch

    New Taipei City, New Taipei, 25160

  • Chung Shan Medical University Hospital

    Taichung, Taichung, 40201

  • Veterans General Hospital - Taichung

    Taichung, Taichung, 40705

  • National Cheng Kung University Hospital

    Tainan, Tainan, 70403

  • National Taiwan University Hospital

    Taipei, Taipei, 10002

  • Shin Kong Wu Ho-Su Memorial Hospital

    Taipei, Taipei, 111045

  • Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation

    Taoyuan, Taoyuan, 33305

Other trials in Taiwan

Mexico8 sites

  • Fundacion Cardiovascular de Aguascalientes AC

    Aguascalientes, Aguascalientes, 20230

  • Hospital Cardiologica Aguascalientes

    Aguascalientes, Aguascalientes, 20230

  • Scientia Investigacion Clinica SC

    Chihuahua City, Chihuahua, 31207

  • Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC

    Culiacán, Sinaloa, 80230

  • Virgen Cardiovascular Research SC

    Guadalajara, Jalisco, 44670

  • Procliniq Investigacion Clinica

    Mexico City, 14050

  • Eukarya PharmaSite

    Monterrey, Nuevo León, 64718

  • Consultorio de Medicina Especializada del Sector Privado

    Xalapa, Veracruz, 91193

Other trials in Mexico

Sweden6 sites

  • Falu Lasarett

    Falun, 791 82

  • Sahlgrenska Universitetssjukhuset

    Gothenburg, 413 45

  • Helsingborgs Lasarett

    Helsingborg, 252 21

  • Clemenstorgets Hjartmottagning

    Lund, 222 21

  • Karolinska Universitetssjukhuset Huddinge

    Stockholm, 141 86

  • Karolinska Universitetssjukhuset Solna

    Stockholm, 171 64

Other trials in Sweden

Finland5 sites

  • Helsinki University Central Hospital

    Helsinki, 000290

  • Satucon Oy/Kuopion tyoterveys

    Kuopio, 70100

  • Oulu University Hospital

    Oulu, 90029

  • Tampere University Hospital

    Tampere, 33520

  • Suomen Terveystalo Oy

    Turku, 20100

Other trials in Finland

Estonia4 sites

  • Innomedica

    Tallinn, 10117

  • Center for Clinical and Basic Research Tallinn

    Tallinn, 10128

  • North Estonia Medical Centre Foundation

    Tallinn, 13419

  • Tartu University Hospital

    Tartu, 50406

Other trials in Estonia

Norway3 sites

  • Oslo Universitetssykehus HF Aker sykehus

    Oslo, 0424

  • Oslo Universitetssykehus HF, Aker sykehus

    Oslo, 0586

  • Skedsmo Medisinske senter

    Skedsmokorset, 2020

Other trials in Norway

Hong Kong2 sites

  • Queen Mary Hospital, The University of Hong Kong

    Hong Kong

  • Prince of Wales Hospital, Chinese University of Hong Kong

    Shatin, New Territories

Other trials in Hong Kong

Czechia1 site

  • Mestska nemocnice Ostrava, po

    Ostrava, 728 80

Other trials in Czechia

Iceland1 site

  • Hjartamidstodin

    Kopavogur, 201

Other trials in Iceland

About this study

Official title: A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Participants With Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a)

The primary objective of this trial is to compare the effect of treatment with olpasiran, to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants with atherosclerotic cardiovascular disease (ASCVD) and elevated Lipoprotein(a).

Being tested
Placebo, Olpasiran
Keywords
Atherosclerotic Cardiovascular Disease, ASCVD, AMG 890, Olpasiran
Medical subject headings
Atherosclerosis

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • PlaceboDrug

    Placebo given by subcutaneous injection once every 12 weeks (Q12W).

  • OlpasiranDrug

    Olpasiran given by subcutaneous injection Q12W.

Study groups in NCT05581303
Study groupRoleWhat they receive
PlaceboPlacebo comparatorPlacebo will be administered by subcutaneous injection.
Receives: Drug: Placebo
OlpasiranExperimentalOlpasiran will be administered by subcutaneous injection.
Receives: Drug: Olpasiran

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time to CHD death, myocardial infarction, or urgent coronary revascularization, whichever occurs first

    Measured: Approximately 5 years

Secondary outcomes (11)

  1. Time to cardiovascular death, myocardial infarction, or ischemic stroke, whichever occurs first

    Measured: Approximately 5 years

  2. Time to cardiovascular death, myocardial infarction, urgent coronary revascularization, or ischemic stroke, whichever occurs first

    Measured: Approximately 5 years

  3. Percent change from baseline to Week 48 in Lipoprotein(a)

    Measured: Baseline and Week 48

  4. Time to myocardial infarction

    Measured: Approximately 5 years

  5. Time to CHD death or myocardial infarction, whichever occurs first

    Measured: Approximately 5 years

  6. Time to urgent coronary revascularization

    Measured: Approximately 5 years

  7. Time to coronary revascularization

    Measured: Approximately 5 years

  8. Time to CHD death

    Measured: Approximately 5 years

  9. Time to cardiovascular death

    Measured: Approximately 5 years

  10. Time to death by any cause

    Measured: Approximately 5 years

  11. Time to ischemic stroke

    Measured: Approximately 5 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted14 Oct 2022
  2. Study start14 Dec 2022
  3. Primary completion31 Mar 2028 (estimated)
  4. Study completion31 Mar 2028 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
7,297 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05581303
Sponsor's protocol ID
20180244
Other IDs
2022-501608-85
Status last verified
Oct 2026
First submitted
12 Oct 2022
Last updated
27 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.
Expanded access
Available

Publications

  • Procyk G, Tyrna P, Mlynarczuk-Bialy I, Budzianowski J, Olasinska-Wisniewska A, Kochman J, Gasecka A. Lipoprotein(a) and clinical outcomes after transcatheter aortic valve implantation: a prospective, multicenter cohort study. Pol Arch Intern Med. 2026 Apr 29;136(4):17253. doi: 10.20452/pamw.17253. Epub 2026 Mar 17.

    PubMed 41841810

  • Byambaa E, Roshanravan B, Berglund L. Lipoprotein(a) and CKD: Insights into New Therapeutic Opportunities. Clin J Am Soc Nephrol. 2026 Aug 1;21(8):1469-1481. doi: 10.2215/CJN.0000000968. Epub 2025 Dec 2.

    PubMed 41329869

  • Nicholls SJ, Nelson AJ, Michael LF. Oral agents for lowering lipoprotein(a). Curr Opin Lipidol. 2024 Dec 1;35(6):275-280. doi: 10.1097/MOL.0000000000000953. Epub 2024 Sep 25.

    PubMed 39329200

  • Burvill A, Watts GF, Norman R, Ademi Z. Early health technology assessment of gene silencing therapies for lowering lipoprotein(a) in the secondary prevention of coronary heart disease. J Clin Lipidol. 2024 Nov-Dec;18(6):e946-e956. doi: 10.1016/j.jacl.2024.08.012. Epub 2024 Aug 31.

    PubMed 39322524

  • Dimitriadis K, Theofilis P, Iliakis P, Pyrpyris N, Dri E, Sakalidis A, Soulaidopoulos S, Tsioufis P, Fragkoulis C, Chrysohoou C, Tsiachris D, Tsioufis K. Management of dyslipidemia in coronary artery disease: the present and the future. Coron Artery Dis. 2024 Sep 1;35(6):516-524. doi: 10.1097/MCA.0000000000001375. Epub 2024 Apr 29.

    PubMed 38682459

  • Karp A, Jacobs M, Barris B, Labkowsky A, Frishman WH. Lipoprotein(a): A Review of Risk Factors, Measurements, and Novel Treatment Modalities. Cardiol Rev. 2025 Jul-Aug 01;33(4):352-358. doi: 10.1097/CRD.0000000000000667. Epub 2024 Feb 28.

    PubMed 38415744

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Olpasiran in people with Atherosclerotic Cardiovascular Disease, run by Amgen at 492 sites in 24 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 27 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 492 sites in United States, Japan, Brazil, China, Germany and 19 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Time to CHD death, myocardial infarction, or urgent coronary revascularization, whichever occurs first (time frame: Approximately 5 years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05581303, which also lists 6 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Oct 2026.

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