AzTrials
AzTrials

Breast NeoplasmsPhase 3EMBER-4NCT05514054

A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer

A Phase 3 study testing Imlunestrant, Tamoxifen and Anastrozole in people with Breast Neoplasms, run by Eli Lilly and Company at 672 sites in 31 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
Search all trials

Trial summary

The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-). Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Breast Neoplasms
What is being tested?
Imlunestrant, Tamoxifen and Anastrozole
Type of treatment
Pill or oral medicine
Could I receive a placebo?
No, everyone receives an active treatment
How many people
8,000 participants
Where
672 sitesin 31 countries
Study dates
4 Oct 2022to Mar 2032
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Have a diagnosis of ER+, HER2- early-stage, resected, invasive breast cancer without evidence of distant metastasis.
  • Participants must have received at least 24 months but not more than 60 months of any adjuvant ET, from time of adjuvant ET initiation.
  • Participants may have received (neo) adjuvant chemotherapy and/or targeted therapy with a CDK4/6- or PARP- inhibitor.
  • Must have an increased risk of disease recurrence based on clinical-pathological risk features.
  • Have a Performance Status of 0 or 1 on the Eastern Cooperative Oncology Group scale.
  • Have adequate organ function.

Who cannot join

  • Have any evidence of metastatic disease (including contralateral ALN) or inflammatory breast cancer at primary breast cancer diagnosis.
  • Participants with more than a 6-month consecutive gap in therapy during the course of prior adjuvant ET.
  • Participants who have completed or discontinued prior adjuvant ET >6 months prior to screening.
  • Participants with a history of previous breast cancer are excluded, with the exception of ipsilateral DCIS treated by locoregional therapy alone ≥5 years ago.
  • Pregnant, breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the screening visit through 180 days after the last dose of study intervention.
  • Participant has previously received ET of any duration for breast cancer prevention (tamoxifen or AIs) or raloxifene.
  • Participants with a history of any other cancer.
  • Have serious preexisting medical conditions that, in the judgment of the investigator, would preclude participation in this study.

Trial locations and contacts

672 sites in 31 countries.

672 sites in 31 countries

United States137 sites

  • New York Oncology Hematology Associate

    Albany, New York, 12206

  • New Mexico Oncology Hematology Consultants Ltd.

    Albuquerque, New Mexico, 87109

  • University of New Mexico Comprehensive Cancer Center

    Albuquerque, New Mexico, 87131

  • AdventHealth Altamonte Springs

    Altamonte Springs, Florida, 32701

  • Messino Cancer Center

    Asheville, North Carolina, 28806

  • Winship Cancer Institute, Emory University

    Atlanta, Georgia, 30322

  • Northside Hospital

    Atlanta, Georgia, 30342

  • Anschutz Cancer Pavilion

    Aurora, Colorado, 80045

  • USO - Texas Oncology

    Austin, Texas, 78731

  • UCSF - John Muir Health Cancer Center Berkeley

    Berkeley, California, 94702

  • Walter Reed National Military Medical Center

    Bethesda, Maryland, 20889

  • St. Luke's University Health Network

    Bethlehem, Pennsylvania, 18015

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215

  • Maimonides Cancer Center

    Brooklyn, New York, 11220

  • NYU Langone Health - Brooklyn

    Brooklyn, New York, 11220

  • MD Anderson Cancer Center at Cooper

    Camden, New Jersey, 08103

  • Aultman Hospital

    Canton, Ohio, 44710

  • University of Virginia Health System

    Charlottesville, Virginia, 22908

  • Northwestern Memorial Hospital

    Chicago, Illinois, 60611

  • University of Illinois at Chicago

    Chicago, Illinois, 60612

  • USO - Oncology Hematology Care

    Cincinnati, Ohio, 45242

  • UCHealth Memorial Hospital

    Colorado Springs, Colorado, 80909

  • University of Missouri Hospital

    Columbia, Missouri, 65212

  • Good Samaritan Regional Medical Center

    Corvallis, Oregon, 97330

  • Ochsner Clinic Foundation

    Covington, Louisiana, 70433

  • USO - Texas Oncology

    Dallas, Texas, 75231

  • USO - Texas Oncology

    Dallas, Texas, 75246

  • Mass General/North Shore Cancer Center

    Danvers, Massachusetts, 01923

  • USO - Southern Cancer Center

    Daphne, Alabama, 36526

  • USO - Texas Oncology

    Denison, Texas, 75020

  • Astera Cancer Care

    East Brunswick, New Jersey, 08816

  • M Health Fairview Cancer Clinic -Edina

    Edina, Minnesota, 55435

  • Texas Oncology - West Texas

    El Paso, Texas, 79902

  • William Beaumont Army Medical Center

    El Paso, Texas, 79918

  • USO - Oncology Associates of Oregon

    Eugene, Oregon, 97401

  • Inova Schar Cancer Institute

    Fairfax, Virginia, 22031

  • Southcoast Centers for Cancer Care

    Fairhaven, Massachusetts, 02719

  • USO - Texas Oncology

    Flower Mound, Texas, 75028

  • Fort Belvoir Community Hospital

    Fort Belvoir, Virginia, 22060

  • UCHealth Harmony

    Fort Collins, Colorado, 80528

  • Brooke Army Medical Center

    Fort Sam Houston, Texas, 78234

  • John Peter Smith Hospital

    Fort Worth, Texas, 76104

  • The Center for Cancer and Blood Disorders

    Fort Worth, Texas, 76104

  • USO - Texas Oncology

    Fort Worth, Texas, 76104

  • Dana-Farber Cancer Institute - Foxborough

    Foxborough, Massachusetts, 02035

  • USO - Texas Oncology

    Fredericksburg, Texas, 78624

  • Washington Health

    Fremont, California, 94538

  • The West Clinic, PLLC dba West Cancer Center

    Germantown, Tennessee, 38138

  • Banner MD Anderson Cancer Center

    Gilbert, Arizona, 85234

  • USO - Arizona Oncology Associates - HAL

    Glendale, Arizona, 85308

  • Banner MD Anderson Cancer Center at North Colorado Medical Center

    Greeley, Colorado, 80631

  • St Francis Cancer Center

    Greenville, South Carolina, 29607

  • Pontchartrain Cancer Center

    Hammond, Louisiana, 70403

  • Memorial Regional Hospital

    Hollywood, Florida, 33021

  • Millennium Oncology Research Clinic

    Hollywood, Florida, 33024

  • Kaiser Permanente Moanalua Medical Center

    Honolulu, Hawaii, 96819

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, 96826

  • USO - Alliance Cancer Specialists, PC

    Horsham, Pennsylvania, 19044

  • Clearview Cancer Institute

    Huntsville, Alabama, 35805

  • Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - Irvine

    Irvine, California, 92612

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224

  • University of Tennessee Medical Center

    Knoxville, Tennessee, 37920

  • R.J. Zuckerberg Cancer Center

    Lake Success, New York, 11042

  • USO - Rocky Mountain Cancer Centers

    Lakewood, Colorado, 80228

  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire, 03756

  • Regional Cancer Care Associates

    Little Silver, New Jersey, 07739

  • Loma Linda University Cancer Center

    Loma Linda, California, 92350-1700

  • Dana-Farber - New Hampshire Oncology/Hematology

    Londonderry, New Hampshire, 03053

  • Banner MD Anderson Cancer Center at McKee Medical Center

    Loveland, Colorado, 80538

  • USO - Texas Oncology

    McAllen, Texas, 78503

  • Dana-Farber Cancer Institute - Merrimack Valley

    Methuen, Massachusetts, 01844

  • Miami Cancer Institute at Baptist Health, Inc.

    Miami, Florida, 33176

  • Bon Secours St. Francis Medical Center

    Midlothian, Virginia, 23114

  • Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center

    Milford, Massachusetts, 01757

  • Perlmutter Cancer Center at NYU Langone Hospital - Long Island

    Mineola, New York, 11501

  • USO - Minnesota Oncology Hematology

    Minneapolis, Minnesota, 55404

  • Allina Health Cancer Institute

    Minneapolis, Minnesota, 55407

  • Infirmary Cancer Care

    Mobile, Alabama, 36607

  • Pacific Cancer Care

    Monterey, California, 93940

  • Northern Westchester Hospital

    Mount Kisco, New York, 10549

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08901

  • Yale-New Haven Hospital

    New Haven, Connecticut, 06510

  • Ochsner Clinic Foundation

    New Orleans, Louisiana, 70121

  • Laura and Isaac Perlmutter Cancer Center

    New York, New York, 10016

  • NYC Health + Hospitals / Bellevue

    New York, New York, 10016

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065

  • Mass General Cancer Center at Newton-Wellesley

    Newton, Massachusetts, 02462

  • USO - Virginia Oncology Associates

    Norfolk, Virginia, 23502

  • Nebraska Methodist Hospital

    Omaha, Nebraska, 68114

  • St. Joseph Hospital

    Orange, California, 92868

  • University of California, Irvine (UCI) Health - UC Irvine Medical Center

    Orange, California, 92868

  • USO - Cancer Care Centers of Brevard

    Palm Bay, Florida, 32901

  • Capital Health Medical Center - Hopewell

    Pennington, New Jersey, 08534

  • USO - Woodlands Medical Specialists

    Pensacola, Florida, 32503

  • Illinois Cancer Care

    Peoria, Illinois, 61615

  • Thomas Jefferson University - Clinical Research Institute

    Philadelphia, Pennsylvania, 19107

  • St. Joseph's Hospital and Medical Center

    Phoenix, Arizona, 85004

  • Mayo Clinic in Arizona - Phoenix

    Phoenix, Arizona, 85054

  • USO - Texas Oncology

    Plano, Texas, 75075

  • Miami Cancer Institute - Plantation

    Plantation, Florida, 33324

  • Oregon Health and Science University

    Portland, Oregon, 97239

  • Lifespan Cancer Institute

    Providence, Rhode Island, 02906

  • Queens Medical Associates

    Queens, New York, 11374

  • USO - Virginia Cancer Specialists

    Reston, Virginia, 20190

  • USO - Oncology & Hematology Associates of Southwest Virginia

    Roanoke, Virginia, 24014

  • Mayo Clinic in Rochester, Minnesota

    Rochester, Minnesota, 55905

  • University of Rochester - Wilmot Cancer Institute

    Rochester, New York, 14642

  • Scott & White Hospital - Round Rock

    Round Rock, Texas, 78665

  • University of California Davis (UC Davis) Comprehensive Cancer Center

    Sacramento, California, 95817

  • Mays Cancer Center

    San Antonio, Texas, 78229

  • Kaiser Permanente San Diego Mission Road

    San Diego, California, 92108

  • Zuckerberg San Francisco General Hospital and Trauma Center

    San Francisco, California, 94110

  • UCSF Medical Center at Mission Bay

    San Francisco, California, 94158

  • Summit Cancer Care, PC

    Savannah, Georgia, 31405

  • Phelps Hospital

    Sleepy Hollow, New York, 10591

  • Dana-Farber/Brigham and Women's Cancer Center - South Shore Hospital

    South Weymouth, Massachusetts, 02190

  • Highlands Oncology Group

    Springdale, Arkansas, 72762

  • Simmons Cancer Institute at SIU

    Springfield, Illinois, 62702

  • Washington University School of Medicine

    St Louis, Missouri, 63108

  • Staten Island University Hospital

    Staten Island, New York, 10305

  • Saint Joseph's Medical Center

    Stockton, California, 95204

  • Tampa General Hospital

    Tampa, Florida, 33606

  • Baylor Scott & White Medical Center - Temple

    Temple, Texas, 76508

  • US Oncology Research Network

    The Woodlands, Texas, 77380

  • USO - Compass Oncology

    Tigard, Oregon, 97223

  • Mercy Health - St. Vincent Medical Center

    Toledo, Ohio, 43608

  • TMC HealthCare

    Tucson, Arizona, 85711

  • The University of Arizona Cancer Center - North Campus

    Tucson, Arizona, 85719

  • Georgetown University Medical Center

    Washington D.C., District of Columbia, 20007

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010

  • USO - Texas Oncology

    Webster, Texas, 77598

  • Clinical Research Alliance

    Westbury, New York, 11590

  • The University of Kansas Cancer Center - Westwood

    Westwood, Kansas, 66205

  • University of Massachusetts Medical School

    Worcester, Massachusetts, 01655

  • York Hospital

    York Village, Maine, 03909

Other trials in United States

China51 sites

  • Anyang Cancer Hospital

    Anyang, 455000

  • Affiliated Hospital of Hebei University

    Baoding, 071000

  • Beijing Hospital

    Beijing, 100005

  • Cancer Hospital Chinese Academy of Medical Science

    Beijing, 100021

  • Peking University People's Hospital

    Beijing, 100034

  • Beijing Friendship Hospital Affiliate of Capital University

    Beijing, 100050

  • The First Hospital of Jilin University

    Changchun, 130021

  • The First People's Hospital of Changde City

    Changde, 415003

  • Xiangya Hospital Central South University

    Changsha, 410008

  • Hunan Cancer Hospital

    Changsha, 421000

  • Sichuan Cancer hospital

    Chengdu, 610042

  • Deyang City People's Hospital

    Deyang, 618000

  • Dongguan People's Hospital

    Dongguan, 523059

  • Shunde Hospital of Southern Medical Univesity

    Foshan, 528399

  • Fujian Medical University Union Hospital-1 Bingfanglou

    Fuzhou, 350001

  • The 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army

    Fuzhou, 350025

  • Sun Yat-sen University Cancer Center

    Guangzhou, 510060

  • Guangdong Maternity and Child Health Care Hospital

    Guangzhou, 511400

  • Hainan General Hospital

    Haikou, 570311

  • The First People's Hospital of Hangzhou

    Hangzhou, 310000

  • Zhejiang Provincial People's Hospital

    Hangzhou, 310014

  • Zhejiang Cancer Hospital

    Hangzhou, 310022

  • First Huai'an Hospital Affiliated to Nanjing Medical University

    Huai'an, 223300

  • Huizhou Municipal Central Hospital

    Huizhou, 516001

  • Jiangmen Center Hospital

    Jiangmen, 529000

  • Jinan Central Hospital

    Jinan, 250013

  • Jining Medical University - Affiliated Hospital

    Jining, 272100

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang, 471003

  • The Third Hospital of Nanchang

    Nanchang, 330009

  • Jiangsu Province Hospital

    Nanjing, 210029

  • The Second People's Hospital of Neijiang

    Neijiang, 641000

  • Hwa Mei Hospital University of Chinese Academy of Sciences

    Ningbo, 315010

  • Ningbo First Hospital

    Ningbo, 315010

  • Fudan University Shanghai Cancer Center

    Shanghai, 200032

  • Cancer Hospital of Shantou University Medical College

    Shantou, 515041

  • ShenZhen People's Hospital

    Shenzhen, 518020

  • Shenzhen Second People's Hospital

    Shenzhen, 518035

  • Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center

    Shenzhen

  • The First Affiliated Hospital of Soochow University

    Suzhou, 215006

  • Tianjin Medical University Cancer Institute & Hospital

    Tianjing, 300060

  • Xinjiang Medical University Cancer Hospital - Urumqi

    Ürümqi, 830000

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, 430022

  • Renmin Hospital of Wuhan University

    Wuhan, 430060

  • Hubei Cancer Hospital

    Wuhan, 430079

  • Wannan Medical College Yijishan Hospital

    Wuhu, 241001

  • The First Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, 710061

  • Xiangyang Central Hospital

    Xiangyang, 441021

  • The Central Hospital of Yongzhou - North Campus

    Yongzhou, 425000

  • The First People's Hospital of Yueyang

    Yueyang, 414000

  • Yuncheng Central Hospital - Eastern Hospital

    Yuncheng, 044000

  • Central Hospital of Guangdong Provincial Agricutural Reclamation

    Zhanjiang, 524002

Other trials in China

Japan50 sites

  • Juntendo University Hospital

    Bunkyō City, 113-8431

  • Chiba University Hospital

    Chiba, 260-8677

  • Chiba cancer center

    Chiba, 260-8717

  • St. Luke's International Hospital

    Chūōku, 104-8560

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, 811-1395

  • Fukushima Medical University

    Fukushima, 960-1295

  • Fukuyama City Hospital

    Fukuyama, 721-8511

  • Gifu University Hospital

    Gifu, 501-1194

  • Tokai University Hachioji Hospital

    Hachioji-shi, 192-0032

  • Kansai Medical University Hospital

    Hirakata, 573-1191

  • Hiroshima City Hospital

    Hiroshima, 730-8518

  • Hiroshima University Hospital

    Hiroshima, 734-8551

  • Shimane University Hospital

    Izumo, 693-0021

  • Sagara Hospital

    Kagoshima, 892-0833

  • Kameda Clinic

    Kamogawa, 296-0041

  • Ishikawa Prefectural Central Hospital

    Kanazawa, 920-8530

  • St. Marianna University Hospital

    Kawasaki, 216-8511

  • Japanese Foundation for Cancer Research

    Kōtō City, 135-8550

  • Kumamoto Breast Surgical Hospital

    Kumamoto, 860-0812

  • Kumamoto Shinto General Hospital

    Kumamoto, 862-8655

  • University Hospital,Kyoto Prefectural University of Medicine

    Kyoto, 602-8566

  • Kyoto University Hospital

    Kyoto, 606-8507

  • Shinshu University Hospital

    Matsumoto, 390-8621

  • National Hospital Organization Shikoku Cancer Center

    Matsuyama, 791-0280

  • Miyazaki Prefectural Miyazaki Hospital

    Miyazaki, 880-8510

  • Kanazawa Medical University Hospital

    Mukai-awagasaki, 920-0265

  • Nagoya University Hospital

    Nagoya, 466-8560

  • Nagoya City University Hospital

    Nagoya, 467-8602

  • Naha Nishi Clinic

    Naha, 901-0154

  • Niigata Cancer Center Hospital

    Niigata, 951-8566

  • Hyogo Medical University Hospital

    Nishinomiya, 663-8501

  • Okayama University Hospital

    Okayama, 700-8558

  • Nakagami Hospital Okinawa

    Okinawa, 904-2195

  • National Hospital Organization - Osaka National Hospital - Institute For Clinical Research

    Osaka, 540-0006

  • Gunma Prefectural Cancer Center

    Otashi, 373-8550

  • Kitasato University Hospital

    Sagamihara, 252-0375

  • Saitama Red Cross Hospital

    Saitama, 330-8553

  • National Hospital Organization Hokkaido Cancer Center

    Sapporo, 003-0804

  • Hokkaido University Hospital

    Sapporo, 060-8648

  • Tohoku University Hospital

    Sendai, 980-8574

  • Showa Medical University Hospital

    Shinagawa City, 142-8555

  • National Center for Global Health and Medicine

    Shinjyuku-ku, 162-8655

  • Shizuoka General Hospital

    Shizuoka, 420-8527

  • National Hospital Organization Takasaki General Medical Center

    Takasaki, 370-0829

  • Tokushima University Hospital

    Tokushima, 770-8503

  • Tsukuba University Hospital

    Tsukuba, 305-8576

  • Tochigi Cancer Center

    Utsunomiya, 320-0834

  • Iwate Medical University Hospital

    Yahaba-cho, Shiwa-gun, 028-3695

  • Yokohama City University Medical Center

    Yokohama, 232-0024

  • Kanagawa cancer center

    Yokohama, 2418515

Other trials in Japan

Spain44 sites

  • CHUAC-Hospital Teresa Herrera

    A Coruña, 15006

  • Hospital General Universitario de Alicante

    Alicante, 03010

  • Hospital Universitario Torrecárdenas

    Almería, 04009

  • Hospital Infanta Cristina

    Badajoz, 06006

  • Parc de Salut Mar - Hospital del Mar

    Barcelona, 08003

  • Hospital Quiron Barcelona

    Barcelona, 08023

  • Hospital Universitari Dexeus

    Barcelona, 08028

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035

  • Hospital Clínic de Barcelona

    Barcelona, 08036

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08041

  • Osi Bilbao-Basurto

    Bilbao, 48013

  • Hospital Universitario de Burgos

    Burgos, 09006

  • Hospital San Pedro de Alcántara

    Cáceres, 10003

  • Hospital Clínico Universitario Virgen de la Arrixaca

    El Palmar, Murcia, 30120

  • Hospital Universitario Getafe

    Getafe, 28905

  • Hospital Universitario San Cecilio

    Granada, 18016

  • Complejo Hospitalario de Jaén

    Jaén, 23007

  • Hospital Universitario Arnau de Vilanova de Lleida

    Lleida, 25198

  • Hospital San Pedro

    Logroño, 26006

  • Hospital Lucus Augusti

    Lugo, 27003

  • Hospital La Princesa

    Madrid, 28006

  • Hospital Beata María Ana

    Madrid, 28007

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28009

  • Hospital Universitario Infanta Leonor

    Madrid, 28031

  • Hospital Ruber Internacional

    Madrid, 28034

  • Hospital Universitario Ramón y Cajal

    Madrid, 28034

  • Hospital Clinico San Carlos

    Madrid, 28040

  • Hospital Universitario 12 de Octubre

    Madrid, 28041

  • Hospital Universitario La Paz

    Madrid, 28046

  • H.R.U Málaga - Hospital Materno-infantil

    Málaga, 29011

  • Hospital Vithas Málaga

    Málaga, 29016

  • Hospital Universitari Son Espases

    Palma, 07120

  • Complejo Hospitalario de Navarra

    Pamplona, 31009

  • Hospital Universitari Sant Joan de Reus

    Reus, 43204

  • Hospital Universitario de Canarias

    San Cristóbal de La Laguna, 38320

  • Hospital Universitari General de Catalunya

    Sant Cugat del Vallès, 08915

  • Hospital Universitario Nuestra Señora de Candelaria

    Santa Cruz de Tenerife, 38010

  • Hospital Universitario Virgen Macarena

    Seville, 41009

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013

  • Hospital Universitario de Toledo

    Toledo, 45007

  • Hospital Clinico de Valencia

    Valencia, 46010

  • Hospital Quirónsalud Valencia

    Valencia, 46010

  • Hospital Clínico Universitario de Valladolid

    Valladolid, 47003

  • Hospital Clínico Universitario Lozano Blesa

    Zaragoza, 50009

Other trials in Spain

Brazil36 sites

  • Fundação Pio XII - Hospital de Câncer de Barretos

    Barretos, 14784400

  • CTO - Centro de Tratamento Oncológico

    Belém, 66063-495

  • Oncocentro de Minas Gerais

    Belo Horizonte, 30180-060

  • Hospital Sirio Libanes

    Brasília, 70200-730

  • Centro Integrado de Oncologia de Curitiba

    Curitiba, 80810050

  • Centro de Pesquisa Clínica do Instituto do Câncer do Ceará

    Fortaleza, 60430230

  • Hospital Araújo Jorge

    Goiânia, 74605070

  • ONCOSITE - Centro de Pesquisa Clinica em Oncologia

    Ijuí, 98700-000

  • Hospital de Cancer de Londrina

    Londrina, 86015-520

  • Hospital Moinhos de Vento

    Porto Alegre, 90035001

  • Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa

    Porto Alegre, 90110-270

  • Hospital São Lucas da PUCRS

    Porto Alegre, 90610-000

  • Hospital de Amor Amazônia

    Porto Velho, 76834-899

  • Multihemo

    Recife, 50070-170

  • Hospital de Clínicas de Ribeirão Preto

    Ribeirão Preto, 14051-140

  • Instituto Nacional de Câncer - INCA

    Rio de Janeiro, 20560121

  • Hospital São Lucas de Copacabana

    Rio de Janeiro, 22061-080

  • Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA

    Rio de Janeiro, 22250-905

  • Instituto de Educação, Pesquisa e Gestão em Saúde

    Rio de Janeiro, 22793080

  • Nucleo de Oncologia da Bahia

    Salvador, 40170-110

  • Faculdade de Medicina do ABC

    Santo André, 09060-650

  • Fundação Faculdade Regional de Medicina de São José do Rio Preto

    São José do Rio Preto, 15090000

  • IPITEC

    São Paulo, 01221-020

  • NotreDame Intermedica Saude S.A

    São Paulo, 01229-010

  • Instituto de Ensino e Pesquisa São Lucas

    São Paulo, 01236030

  • Icesp - Instituto Do Câncer Do Estado de São Paulo

    São Paulo, 01246-000

  • Hospital Sírio Libanês

    São Paulo, 01308-060

  • Clínica de Pesquisa e Centro de Estudos em Ginecologia Oncológica e Mamária LTDA

    São Paulo, 01317-001

  • Hospital BP

    São Paulo, 01321-001

  • Hospital Alemao Oswaldo Cruz

    São Paulo, 01327-001

  • A. C. Camargo Cancer Center

    São Paulo, 01509-010

  • Núcleo de Pesquisa Clínica da Rede São Camilo

    São Paulo, 04014-002

  • Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T

    São Paulo, 04039-901

  • Instituto D'Or de Pesquisa e Ensino (IDOR)

    São Paulo, 04543-000

  • Hospital Santa Paula

    São Paulo, 04556-100

  • CEDOES

    Vitória, 29055450

Other trials in Brazil

France34 sites

  • Sainte Catherine Institut du Cancer Avignon Provence

    Avignon, 84918

  • Centre Hospitalier de la Côte Basque

    Bayonne, 64109

  • CHU Besançon

    Besançon, 25000

  • Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest

    Bordeaux, 33076

  • CHRU de Brest

    Brest, 29609

  • Pole Santé République

    Clermont-Ferrand, 63050

  • Henri Mondor Hospital

    Créteil

  • Polyclinique De Blois

    La Chaussée-Saint-Victor, 41260

  • CHD Vendee

    La Roche-sur-Yon, 85000

  • Groupe Hospitalier La Rochelle-Ré-Aunis - Hôpital Saint Louis

    La Rochelle, 17019

  • Chu Grenoble Alpes

    La Tronche, 38700

  • Clinique Victor Hugo Le Mans

    Le Mans, 72000

  • Clinique Francois Chenieux

    Limoges, 87039

  • Hopital Prive Jean Mermoz

    Lyon, 69008

  • Centre Hospitalier Régional Metz Thionville - Hôpital de Mercy

    Metz, 57085

  • Centre Hospitalier Intercommunal de Mont-de-Marsan et du Pays des Sources

    Mont-de-Marsan, 40024

  • Centre de Cancérologie du Grand Montpellier

    Montpellier, 34070

  • Polyclinique de Gentilly

    Nancy, 54100

  • Centre Antoine-Lacassagne

    Nice, 06189

  • Hôpital Saint-Louis

    Paris, 75010

  • Groupe hospitalier Paris saint Joseph

    Paris, 75014

  • Hôpital Européen Georges Pompidou

    Paris, 75015

  • Groupe Hospitalier Diaconesses Croix Saint Simon

    Paris, 75020

  • Institut Curie

    Paris, 75248

  • Hôpital Tenon

    Paris, 75970

  • Centre Hospitalier de Pau

    Pau, 64000

  • Centre Catalan d'Oncologie

    Perpignan, 66000

  • Centre Hospitalier Universitaire de Poitiers

    Poitiers, 86021

  • Institut Jean Godinot

    Reims, 51726

  • Institut Curie - site Saint-Cloud

    Saint-Cloud, 92210

  • Centre Hospitalier Privé Saint-Grégoire

    Saint-Grégoire, 35768

  • Institut de Cancérologie de l'Ouest

    Saint-Herblain, 44805

  • Centre de cancérologie des Dentellières

    Valenciennes, 59300

  • Institut de Cancérologie de Lorraine Alexis Vautrin

    Vandœuvre-lès-Nancy, 54519

Other trials in France

Germany34 sites

  • Gemeinschaftspraxis hop-augsburg

    Augsburg, 86150

  • Universitaetsklinikum Augsburg

    Augsburg, 86156

  • Praxisklinik Krebsheilkunde fur Frauen

    Berlin, 10367

  • Onkologische Schwerpunktpraxis Kurfuerstendamm

    Berlin, 10707

  • Helios Klinikum Berlin-Buch

    Berlin, 13125

  • Marienhospital Bottrop

    Bottrop, 46236

  • Universitaetsklinikum Koeln

    Cologne, 50937

  • Städtisches Klinikum Dessau

    Dessau, 06847

  • Onkologiezentrum Donauwörth

    Donauwörth, 86609

  • St.-Johannes-Hospital Dortmund

    Dortmund, 44137

  • MVZ Medical Center Düsseldorf GmbH

    Düsseldorf, 40235

  • Universitaetsklinikum Erlangen

    Erlangen, 91054

  • Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung

    Essen, 45136

  • Agaplesion Markus Krankenhaus

    Frankfurt, 60431

  • Universitaetsklinikum Freiburg

    Freiburg im Breisgau, 79106

  • Private Practice - Dr. Helmut Oettle und Prof.Dr.med. Frank Mayer

    Friedrichshafen, 88045

  • SRH Wald-Klinikum Gera

    Gera, 07548

  • OSP Göttingen

    Göttingen, 37073

  • St. Anna Hospital

    Herne, 44649

  • Universitaetsklinikum des Saarlandes

    Homburg, 66421

  • Klinikverbund Allgäu gGmbH

    Kempten, 87439

  • Universitaetsklinikum Schleswig-Holstein Campus Kiel

    Kiel, 24105

  • Zentrum fuer ambulante gynaekologische Onkologie (ZAGO)

    Krefeld, 47805

  • Universitätsmedizin Mannheim

    Mannheim, 68167

  • Onkologisch-hämatologisches Forschungsinstitut am Habsburgring

    Mayen, 56727

  • Klinikum der Ludwig-Maximilians-Universitaet Muenchen

    München, 80336

  • Klinikum Ernst von Bergmann

    Potsdam, 14467

  • HELIOS Kliniken Schwerin

    Schwerin, 19055

  • Robert-Bosch-Krankenhaus

    Stuttgart, 70376

  • SRH Zentralklinikum Suhl

    Suhl, 98527

  • Klinikum Mutterhaus der Borromäerinnen

    Trier, 54290

  • Universitaetsklinikum Tuebingen

    Tübingen, 72076

  • Universitaetsklinikum Ulm

    Ulm, 89075

  • Helios HSK Wiesbaden

    Wiesbaden, 65199

Other trials in Germany

Turkey (Türkiye)25 sites

  • Adana Medical Park Seyhan Hastanesi

    Adana, 01140

  • Adana City Hospital

    Adana, 01370

  • Sakarya Training and Research Hospital

    Adapazarı, 54290

  • Hacettepe Universitesi

    Altindağ, 06230

  • Ankara Gülhane Eitim ve Aratrma Hastanesi

    Ankara, 06010

  • Ankara Etlik City Hospital

    Ankara, 06170

  • Memorial Ankara Hastanesi

    Ankara, 06520

  • Ankara Bilkent Şehir Hastanesi

    Ankara, 06800

  • Akdeniz Universitesi Hastanesi

    Antalya, 07059

  • Antalya Egitim ve Arastırma Hastanesi

    Antalya, 07100

  • Uludag Universitesi

    Bursa, 16059

  • Dicle Üniversitesi

    Diyarbakır, 21200

  • Trakya University Medical Faculty Hospital

    Edirne, 22030

  • Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi

    Gaziantep, 27310

  • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

    Istanbul, 34722

  • Marmara Universitesi Pendik Egitim Arastirma Hastanesi

    Istanbul, Pendik, 34899

  • Ege Universitesi Hastanesi

    Izmir, 35100

  • zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi

    Izmir, 35360

  • Izmir Medical Park Hospital

    Izmir, Karsiyaka, 009035575

  • Kocaeli Üniversitesi

    Kocaeli, 41380

  • İnönü Üniversitesi Turgut Özal Tıp Merkezi Eğitim ve Araştırma Hastanesi

    Malatya, 44280

  • Mersin University

    Mersin, 33110

  • Mugla Sitki Kocman Universitesi Egitim ve Arastirma Hastanesi

    Muğla, 48000

  • Ondokuz Mayıs Universitesi

    Samsun, 55270

  • Medipol Mega Universite Hastanesi

    Stanbul, 34214

Other trials in Turkey (Türkiye)

Australia22 sites

  • Ballarat Health Services

    Ballarat Central, 3350

  • Box Hill Hospital

    Box Hill, 3128

  • Monash Health

    Clayton, 3168

  • Coffs Harbour Health Campus

    Coffs Harbour, 2450

  • St Vincent's Hospital

    Darlinghurst, 2010

  • Barwon Health

    Geelong, 3220

  • Royal Hobart Hospital

    Hobart, 7000

  • Launceston General Hospital

    Launceston, 7250

  • Liverpool Hospital

    Liverpool, 2170

  • Mackay Base Hospital

    Mackay, 4740

  • St Vincent's Hospital

    Melbourne, 3065

  • Northern Hospital

    Melbourne, 3076

  • Maroondah Hospital

    Melbourne, 3135

  • Breast Cancer Research Centre-WA

    Nedlands, 6009

  • Lake Macquarie Private Hospital

    Newcastle, 2290

  • Goulburn Valley Health

    Shepparton, 3630

  • Gold Coast University Hospital

    Southport, 4215

  • Mater Hospital Sydney

    Sydney, 2060

  • Royal Darwin Hospital

    Tiwi, 0810

  • The Townsville Hospital

    Townsville, 4814

  • Hervey Bay Hospital

    Urraween, 4655

  • The Queen Elizabeth Hospital

    Woodville, 5011

Other trials in Australia

South Korea21 sites

  • Dongnam Institute of Radiological and Medical Sciences

    Busan, 46033

  • Soon Chun Hyang University Cheonan Hospital

    Cheonan-si, 31151

  • Chungbuk National University Hospital

    Cheongju-si, 28644

  • Kyungpook National University Chilgok Hospital

    Daegu, 41404

  • National Cancer Center

    Goyang-si, 10408

  • Yeungnam Univeristy Medical Center

    Gyeongsan-si, 42415

  • Chonnam National University Hwasun Hospital

    Hwasun-gun, 58128

  • Inha University Hospital

    Incheon, 22332

  • Gachon University Gil Medical Center

    Namdong-gu, 21565

  • Seoul National University Bundang Hospital

    Seongnam, 13620

  • CHA Bundang Medical Center, CHA University

    Seongnam-si, 13496

  • Korea University Anam Hospital

    Seoul, 02841

  • Seoul National University Hospital

    Seoul, 03080

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722

  • Asan Medical Center

    Seoul, 05505

  • Gangnam Severance Hospital

    Seoul, 06273

  • Samsung Medical Center

    Seoul, 06351

  • The Catholic Univ. of Korea Seoul St. Mary's Hospital

    Seoul, 06591

  • Korea University Guro Hospital

    Seoul, 08308

  • Ajou University Hospital

    Suwon, 16499

  • Ulsan University Hospital

    Ulsan, 44033

Other trials in South Korea

Argentina20 sites

  • Centro de Oncología e Investigación de Buenos Aires

    Berazategui, B1884BBF

  • Centro de Investigaciones Medicas y Desarrollo LC

    Buenos Aires, 1113

  • Investigaciones Clinicas Moleculares (ICM)

    Buenos Aires, 1425

  • Centro Oncologico Korben

    Buenos Aires, 1426

  • CIPREC

    Buenos Aires, C1061

  • Mautalen Salud e Investigación

    Buenos Aires, C1128AAF

  • Fundación Respirar

    Buenos Aires, C1426ABP

  • Instituto Alexander Fleming

    Buenos Aires, C1426ANZ

  • Clinica Adventista Belgrano

    CABA, C1430EGF

  • Centro Medico Privado CEMAIC

    Capital, X5008HHW

  • Fundación CORI para la Investigación y Prevención del Cáncer

    La Rioja, F5300COE

  • Instituto de Investigaciones Clínicas Mar del Plata

    Mar del Plata, B7600FZO

  • Fundacion Scherbovsky

    Mendoza, 5500

  • Instituto Médico Río Cuarto

    Río Cuarto, 5800

  • Fundacion Estudios Clinicos

    Rosario, S2000DEJ

  • Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan

    San Juan, 5400

  • Instituto San Marcos

    San Juan, 5400

  • Exelsus Oncología Clínica

    San Miguel de Tucumán, 4000

  • Go Centro Medico San Nicolás

    San Nicolás, 2900

  • Clinica Viedma S. A

    Viedma, R8500ACE

Other trials in Argentina

Italy20 sites

  • Aou Ospedali Riuniti Umberto I

    Ancona, 60126

  • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII

    Bergamo, 24127

  • IRCCS - AOU di Bologna

    Bologna, 40138

  • Ospedale Antonio Perrino

    Brindisi, 72100

  • Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia

    Candiolo, 10060

  • Azienda Ospedaliera Universitaria Careggi

    Florence, 50134

  • Ospedale San Martino

    Genova, 16132

  • Istituto Europeo di Oncologia IRCCS

    Milan, 20141

  • Humanitas Istituto Clinico Catanese

    Misterbianco, 95045

  • Azienda Ospedaliero Universitaria

    Modena, 41125

  • Ospedale San Gerardo-ASST Monza

    Monza, 20900

  • University of Naples Federico II

    Naples, 80100

  • Istituto Nazionale Tumori IRCCS Fondazione Pascale

    Naples, 80131

  • Istituto Oncologico Veneto IRCCS

    Padova, 35128

  • Azienda Ospedaliero Universitaria di Parma

    Parma, 43126

  • Ospedale Generale Provinciale Macerata

    Province of Macerata, 62100

  • Istituto Nazionale Tumori Regina Elena

    Rome, 00144

  • Humanitas

    Rozzano, 20089

  • Ospedale San Giovanni Moscati

    Statte, 74100

  • Azienda Ospedaliera Santa Maria Terni

    Terni, 05100

Other trials in Italy

India18 sites

  • Hemato Oncology Clinic

    Ahmedabad, 380054

  • KD Hospital

    Ahmedabad, 382421

  • Medstar Speciality Hospital

    Bangalore, 560092

  • KLES Dr. Prabhakar Kore Hospital & M.R.C

    Belagavi, 590010

  • All India Institute of Medical Sciences

    Bhubaneswar, 751019

  • Postgraduate Institute of Medical Education & Research

    Chandigarh, 160012

  • Cancer Institute (WIA)

    Chennai, 600036

  • Nizam's Institute of Medical Sciences

    Hyderabad, 500082

  • Regency Hospital

    Kanpur, 208005

  • Krishna Institute of Medical Sciences - Karad

    Karad, 415539

  • Kolhapur Cancer Centre Private Limited

    Kolhāpur, 416234

  • Tata Memorial Hospital

    Mumbai, 400012

  • Rashtrasant Tukdoji Regional Cancer Hospital

    Nagpur, 440027

  • Delhi State Cancer Institute

    New Delhi, 110095

  • Grant Medical Foundation - Ruby Hall Clinic

    Pune, 411001

  • Lifepoint Multispeciality Hospital

    Pune, 411057

  • Regional Cancer Centre - Thiruvananthapuram

    Thiruvananthapuram, 695011

  • Mahatma Gandhi Cancer Hospital and Research Institute

    Visakhapatnam, 530017

Other trials in India

Mexico18 sites

  • Scientia Investigacion Clinica S.C.

    Chihuahua City, 31207

  • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares

    Ciudad Madero, 89440

  • CIO - Centro de Inmuno-Oncología de Occidente

    Guadalajara, 44630

  • Clinica de Investigacion en Reumatologia y Obesidad S. C.

    Guadalajara, 44650

  • Preparaciones Oncologicas

    León, 37178

  • CENEIT Oncológicos. Centro Especializado en Investigación y Tratamientos Oncológicos

    Mexico City, 03100

  • Grupo Medico Camino Sc

    Mexico City, 03310

  • Axis Heilsa S. de R.L. de C.V.

    Monterrey, 64040

  • Centro Regiomontano de Investigación

    Monterrey, 64060

  • Filios Alta Medicina

    Monterrey, 64460

  • Oaxaca Site Management Organization

    Oaxaca City, 68000

  • Centro de Investigacion Clinica de Oaxaca

    Oaxaca City, 68020

  • Unidad Médica Onco-hematológica

    Puebla City, 72424

  • PanAmerican Clinical Research - Querétaro - Avenida Antea

    Querétaro, 76100

  • Oncologico Potosino, S.C.

    San Luis Potosí City, 78209

  • Centro Medico Zambrano Hellion

    San Pedro Garza García, 66278

  • Hospital Angeles

    Tijuana, 22010

  • Centro Oncologico Estatal ISSEMyM ( COEI )

    Toluca, 50180

Other trials in Mexico

Belgium17 sites

  • Institut Jules Bordet

    Anderlecht, 1070

  • CHIREC - site delta

    Auderghem, 1160

  • CHU Saint-Pierre

    Brussels, 1000

  • Centre Hospitalier Universitaire Brugmann

    Brussels, 1020

  • Cliniques universitaires Saint-Luc

    Brussels, 1200

  • Grand Hôpital de Charleroi

    Charleroi, 6000

  • Jessa Ziekenhuis

    Hasselt, 3500

  • Jan Yperman Ziekenhuis

    Ieper, 8900

  • AZ Groeninge Campus Kennedylaan

    Kortrijk, 8500

  • Groupe Jolimont

    La Louvière, 7100

  • UZ Leuven

    Leuven, 3000

  • Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman

    Liège, 4000

  • CHU UCL Namur/Site Sainte Elisabeth

    Namur, 5000

  • AZ Oostende vzw

    Ostend, 8400

  • Clinique Saint Pierre

    Ottignies, 1340

  • AZ Nikolaas

    Sint-Niklaas, B-9100

  • CHR Verviers - La Tourelle

    Verviers, 4800

Other trials in Belgium

Greece14 sites

  • Agios Savvas Regional Cancer Hospital

    Athens, 115 22

  • Alexandra Hospital

    Athens, 115 28

  • IASO Obstetrics - Gynecology Clinic

    Athens, 151 23

  • Iaso Private General Obstetrics Gynecological & Pediatric Clinic Diagnostic Therapeutic & Research Center -T

    Athens, 151 23

  • Attikon General University Hospital

    Chaïdári, 12462

  • University General Hospital of Heraklion

    Heraklion, 711 10

  • University Hospital of Ioannina

    Ioannina, 455 00

  • University General Hospital of Larissa

    Larissa, 41110

  • General Oncology Hospital of Kifissia "Agioi Anargiroi"

    Nea Kifissia, 145 64

  • Olympion General Clinic

    Pátrai, 26443

  • University Hospital of Patras

    Pátrai, 26504

  • BioClinic Thessaloniki

    Thessaloniki, 546 22

  • Agios Loukas Clinic

    Thessaloniki, 552 36

  • European Interbalkan Medical Center

    Thessaloniki, 570 01

Other trials in Greece

United Kingdom13 sites

  • Colchester General Hospital

    Colchester, CO4 5JL

  • Hairmyres Hospital

    East Kilbride, Glasgow, G75 8RG

  • Western General Hospital

    Edinburgh, EH4 2XU

  • Clatterbridge Cancer Centre - Liverpool

    Liverpool, L7 8YA

  • St Bartholomew's Hospital

    London, EC1A 7BE

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX

  • Mount Vernon Hospital

    Northwood, HA6 2RN

  • Derriford Hospital

    Plymouth, Pl6 8DH

  • Panthera Biopartners - Preston

    Preston, PR2 9QB

  • Royal Berkshire Hospital

    Reading, RG1 5AN

  • Panthera Biopartners - Manchester

    Rochdale, OL11 4AU

  • Lister Hospital

    Stevenage, SG1 4AB

  • Oncology Research

    Wigan, WN1 2NN

Other trials in United Kingdom

Netherlands11 sites

  • Wilhelmina Ziekenhuis Assen

    Assen, 9401 RK

  • Amphia Ziekenhuis, locatie Breda Molengracht

    Breda, 4818 CK

  • Reinier de Graaf Ziekenhuis, locatie Delft

    Delft, 2625 AD

  • Deventer Ziekenhuis

    Deventer, 7416 SE

  • Albert Schweitzer Ziekenhuis, locatie Dordwijk

    Dordrecht, 3318 AT

  • Ziekenhuisgroep Twente, locatie Almelo

    Hengelo, 7555 DL Hengelo

  • Spaarne Gasthuis - Hoofddorp

    Hoofddorp, 2134 TM

  • Maastricht UMC+

    Maastricht, 6229 HX

  • Haga Ziekenhuis locatie Leyweg

    The Hague, 2545 AA

  • VieCuri Medisch Centrum, locatie Venlo

    Venlo, 5912 BL

  • Zaans Medisch Centrum

    Zaandam, 1502 DV

Other trials in Netherlands

Romania11 sites

  • C.M.D.T.A. Neomed

    Brasov, 500283

  • Onco Medint Srl

    Bucharest, 010644

  • Lotus-Med

    Bucharest, 012292

  • SC Memorial Healthcare International SRL

    Bucharest, 013812

  • Spitalul Clinic Colțea

    Bucharest, 030171

  • Gral Medical Diagnostic Center

    Bucharest, 031422

  • Institutul Oncologic Cluj

    Cluj-Napoca, 400015

  • Centrul de Oncologie "Sfântul Nectarie"

    Craiova, 200542

  • Radiology Therapeutic Center

    Otopeni, 075100

  • Ovidius Clinical Hospital OCH

    Ovidiu, 905900

  • S C Oncocenter Oncologie Clinica S R L

    Timișoara, 300166

Other trials in Romania

Taiwan11 sites

  • Changhua Christian Hospital

    Changhua County, 50006

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807

  • Taipei Tzu Chi General Hospital

    New Taipei City, 231

  • Taichung Veterans General Hospital

    Taichung, 407219

  • National Cheng Kung University Hospital

    Tainan, 704

  • Chi Mei Hospital - Liouying Branch

    Tainan, 73657

  • National Taiwan University Hospital

    Taipei, 10002

  • Mackay Memorial Hospital

    Taipei, 10449

  • Taipei Veterans General Hospital

    Taipei, 11217

  • Koo Foundation Sun Yat-Sen Cancer Center

    Taipei, 112

  • Chang Gung Medical Foundation-Linkou Branch

    Taoyuan, 333

Other trials in Taiwan

Canada9 sites

  • Arthur J.E. Child Comprehensive Cancer Centre

    Calgary, T2N 5G2

  • Victoria Hospital & Children's Hospital - London Health Sciences Centre

    London, N6A 5W9

  • Centre Hospitalier de l'Université de Montréal

    Montreal, H2X 3E4

  • Jewish General Hospital

    Montreal, H3T 1E2

  • Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎM) - H -T

    Montreal, H4J 1C5

  • CHU de Québec-Université Laval, Hôpital du Saint-Sacrement

    Québec, G1S 4L8

  • BC Cancer Surrey

    Surrey, V3V 1Z2

  • Humber River Hospital

    Toronto, M3M 0B2

  • Sunnybrook Research Institute

    Toronto, M4N 3M5

Other trials in Canada

Ireland9 sites

  • Bon Secours Cork Hospital

    Cork, T12 DV56

  • Cork University Hospital

    Cork, T12 E8YV

  • St. Vincent's University Hospital

    Dublin, D04 N2E0

  • St. James's Hospital

    Dublin, D08 E9P6

  • UCD School of Medicine Beacon Hospital

    Dublin, D18 AK68

  • Beaumont Hospital, Dublin

    Dublin, D9

  • Galway University Hospital

    Galway, H91 YR71

  • Sligo General Hospital

    Sligo, F91 H684

  • Waterford Regional Hospital

    Waterford, X91 ER8E

Other trials in Ireland

Poland9 sites

  • Szpitale Pomorskie Sp. z o. o.

    Gdynia, 81-519

  • Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie

    Koszalin, 75-581

  • Salve Medica

    Lodz, 91-211

  • Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Koszarowskiego

    Opole, 45-061

  • FORMED2

    Oświęcim, 32-600

  • Mazowiecki Szpital Wojewódzki w Siedlcach

    Siedlce, 08-110

  • MICS Centrum Medyczne Torun

    Torun, 87-100

  • Luxmed Onkologia sp. z o. o.

    Warsaw, 01-748

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie

    Warsaw, 02-781

Other trials in Poland

Czechia8 sites

  • Masarykuv onkologicky ustav

    Brno, 656 53

  • Nemocnice Horovice

    Hořovice, 268 31

  • Fakultni nemocnice Hradec Kralove

    Hradec Králové, 500 05

  • Fakultni nemocnice Ostrava

    Ostrava, 708 52

  • Multiscan

    Pardubice, 53203

  • Fakultni Thomayerova nemocnice

    Prague, 14059

  • Fakultni nemocnice Motol

    Prague, 150 06

  • Fakultni nemocnice Bulovka

    Prague, 180 81

Other trials in Czechia

Israel8 sites

  • Carmel Hospital

    Haifa, 3436212

  • Shaare Zedek Medical Center

    Jerusalem, 9013102

  • Hadassah Medical Center

    Jerusalem, 9112001

  • Meir Medical Center

    Kfar Saba, 4428164

  • Rabin Medical Center

    Petah Tikva, 4941492

  • Sheba Medical Center

    Ramat Gan, 5265601

  • Sourasky Medical Center

    Tel Aviv, 6423906

  • Yitzhak Shamir Medical Center

    Tsrifin, 70300

Other trials in Israel

Austria6 sites

  • Medizinische Universität Graz

    Graz, 8036

  • Uniklinikum Salzburg

    Salzburg, 5020

  • Private Practice - Dr. Hubalek

    Schwaz, 6130

  • Medizinische Universität Wien

    Vienna, 1090

  • Universitaetsklinikum Allgemeines Krankenhaus Wien

    Vienna, 1090

  • Klinik Hietzing

    Vienna, 1130

Other trials in Austria

Portugal6 sites

  • Hopital Garcia de Orta

    Almada, 2805-267

  • Champalimaud Foundation

    Lisbon, 1400-038

  • Hospital da Luz Lisboa

    Lisbon, 1500-650

  • Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria

    Lisbon, 1649-035

  • Hospital Beatriz Ângelo

    Lisbon, 2674-514

  • Centro Hospitalar de Vila Nova de Gaia/Espinho - Unidade I

    Vila Nova de Gaia, 4434-502

Other trials in Portugal

Hungary5 sites

  • Országos Onkológiai Intézet

    Budapest, 1122

  • Uzsoki Utcai Kórház

    Budapest, 1145

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032

  • Bacs-Kiskun Megyei Korhaz

    Kecskemét, 6000

  • Szabolcs Szatmár Bereg Vármegyei Oktatókórház

    Nyíregyháza, 4400

Other trials in Hungary

Singapore2 sites

  • National Cancer Centre Singapore

    Singapore, 168583

  • Raffles Hospital

    Singapore, 188770

Other trials in Singapore

Slovakia2 sites

  • Onkologicky Ustav sv. Alzbety

    Bratislava, 812 50

  • Narodny onkologicky ustav

    Bratislava, 833 10

Other trials in Slovakia

Hong Kong1 site

  • Queen Mary Hospital

    Hksar

Other trials in Hong Kong

About this study

Official title: EMBER-4: A Randomized, Open-Label, Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients Who Have Previously Received 2 to 5 Years of Adjuvant Endocrine Therapy for ER+, HER2- Early Breast Cancer With an Increased Risk of Recurrence

The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-). Participants must have already taken endocrine therapy for two to five years and must have a higher-than-average risk for their cancer to return. Study participation could last up to 10 years.

Being tested
Imlunestrant, Tamoxifen, Anastrozole, Letrozole, Exemestane
Medical subject headings
Breast Neoplasms

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • ImlunestrantDrug

    Also called LY3484356

    Administered orally.

  • TamoxifenDrug

    Administered per local approved label.

  • AnastrozoleDrug

    Administered per local approved label.

  • LetrozoleDrug

    Administered per local approved label.

  • ExemestaneDrug

    Administered per local approved label.

Study groups in NCT05514054
Study groupRoleWhat they receive
ImlunestrantExperimentalImlunestrant administered orally.
Receives: Drug: Imlunestrant
Investigator's Choice of Endocrine TherapyActive comparatorInvestigator's choice of tamoxifen, anastrozole, letrozole, or exemestane administered per local approved label.
Receives: Drug: Tamoxifen; Drug: Anastrozole; Drug: Letrozole; Drug: Exemestane

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Invasive Disease-Free Survival (IDFS)

    IDFS excluding second non-breast primary invasive cancers

    Measured: Randomization to recurrence or death from any cause (up to 10 years)

Secondary outcomes (7)

  1. Distant Recurrence-Free Survival (DRFS)

    DRFS

    Measured: Randomization to Distant Recurrence or Death from Any Cause (up to 10 Years)

  2. Overall Survival (OS)

    OS

    Measured: Randomization to Death from Any Cause (up to 10 Years)

  3. Pharmacokinetics (PK): Steady State Plasma Concentrations of Imlunestrant

    PK: steady state plasma concentrations of imlunestrant

    Measured: Year 1, Month 2 to Month 4

  4. Change from Baseline in the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (EORTC QLQ-C30) Physical Functioning

    The EORTC QLQ-C30 is a 30-question patient reported instrument used to assess multidimensional quality of life (QOL) in cancer patients. It consists of 15 domains: 1 global QOL scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, Financial Impact). Physical functioning was measured by items 1 to 5. The sum score was linearly transformed to the range 0 - 100 as recommended by the EORTC (higher score is better).

    Measured: Visit 1 Day 1 up to end of Year 5

  5. Change from Baseline in the EORTC QLQ-C30 Role Functioning

    The EORTC QLQ-C30 is a 30-question patient reported instrument used to assess the multidimensional QOL in cancer patients. It consists of 15 domains: 1 global QOL scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, Financial Impact). Role functioning was measured by items 6 and 7. The sum score was linearly transformed to the range 0 - 100 as recommended by the EORTC (higher score is better).

    Measured: Visit 1 Day 1 up to end of Year 5

  6. Change from Baseline in the EORTC QLQ-C30 Global QOL

    The EORTC QLQ-C30 is a 30-question patient reported instrument used to assess the multidimensional QOL in cancer patients. It consists of 15 domains: 1 global QOL scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, Financial Impact). Global QOL was measured by items 29 and 30. The sum score was linearly transformed to the range 0 - 100 as recommended by the EORTC (higher score is better).

    Measured: Visit 1 Day 1 up to end of Year 5

  7. Proportion of Time on Study Treatment with High Overall Adverse Event Burden

    FACT GP5 = Functional Assessment of Cancer Therapy - General Physical Well-being Item 5 (FACT GP5). High overall adverse event burden is defined as a score of 3 or 4 on a 5-point Likert scale. Higher scores represent higher symptom burden.

    Measured: Visit 1 Day 1 up to end of Year 5

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted24 Aug 2022
  2. Study start4 Oct 2022
  3. Primary completionOct 2027 (estimated)
  4. Study completionMar 2032 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
8,000 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05514054
Sponsor's protocol ID
18459
Other IDs
J2J-MC-JZLH, 2022-501007-28
Acronym
EMBER-4
Status last verified
Apr 2026
First submitted
23 Aug 2022
Last updated
2 Apr 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Imlunestrant, Tamoxifen and Anastrozole in people with Breast Neoplasms, run by Eli Lilly and Company at 672 sites in 31 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 2 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 672 sites in United States, China, Japan, Spain, Brazil and 26 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Invasive Disease-Free Survival (IDFS) (time frame: Randomization to recurrence or death from any cause (up to 10 years)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05514054.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Apr 2026.

AzTrials uses cookies for analytics and advertising. You can accept or reject them; the site works either way. Privacy Policy.

Free account

Log in to keep searching

You’ve used your 3 free searches. AzTrials is free: log in or create a free account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in