AzTrials
AzTrials

End Stage Kidney DiseasePhase 2/3POSIBIL6ESKDNCT05485961

Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)

A Phase 2/3 study testing CSL300 in people with End Stage Kidney Disease, run by CSL Behring at 566 sites in 35 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

This is a two-part, phase 2b and phase 3 combined prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study. Part 1: Phase 2b is a dose-finding study for CSL300 vs placebo. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
End Stage Kidney Disease
What is being tested?
CSL300
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
3,110 participants
Where
566 sitesin 35 countries
Study dates
27 Apr 2024to 22 May 2029
Phase
Phase 2/3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Male or female at least 18 years of age.
  • A diagnosis of ESKD undergoing maintenance dialysis for at least 12 weeks.
  • Serum hs-CRP ≥ 2.0 mg/L.
  • A diagnosis of diabetes mellitus OR ASCVD.

Who cannot join

  • Subjects who participated in Part 1 (phase 2b) are not eligible to participate in Part 2 (phase 3).
  • Concomitant use of systemic immunosuppressant drugs.
  • Part 1 (Phase 2b) excludes subjects with a positive TB or a history of latent TB, whereas Part 2 (Phase 3) excludes active TB but allows inclusion of subjects with a latent TB and at least 4 weeks of prophylactic TB treatment.
  • Abnormal LFTs.
  • Any life-threatening disease expected to result in death within 12 months.
  • A history of GI perforation, inflammatory bowel disease (except fully excised. ulcerative colitis), or peptic ulcer disease.
  • Clinically significant active infection or history of opportunistic or invasive fungal infection.

Trial locations and contacts

566 sites in 35 countries. Contact the study team or a site near you to ask about taking part.

Trial Registration Coordinator contact

+1 610-878-4697

clinicaltrials@cslbehring.com

566 sites in 35 countries

United States167 sites, 149 recruiting

  • Southwest Georgia Nephrology Clinic

    Albany, Georgia, 31701

    Withdrawn

  • Albany Medical College Committee of Research Involving Human Subjects

    Albany, New York, 12208

    Recruiting

  • Western Nephrology

    Arvada, Colorado, 80002

    Trial Information Contact, 303-232-3366, kmydosh@westneph.com

    Recruiting

  • Cussimanio Research Group LLC

    Austin, Texas, 78751

    Use Central Contact

    Recruiting

  • Research Management, Inc.

    Austin, Texas, 78758

    Use Central Contact

    Recruiting

  • National Institute of Clinical Research

    Bakersfield, California, 93309

    Use Central Contact

    Recruiting

  • Renal Associates of Baton Rouge

    Baton Rouge, Louisiana, 70808

    Use Central Contact

    Recruiting

  • MW Clinical Research Center

    Beaumont, Texas, 77701

    Use Central Contact

    Recruiting

  • Northeast Clinical Research Center, LLC

    Bethlehem, Pennsylvania, 18017

    Use Central Contact

    Recruiting

  • Amicis Research Center

    Beverly Hills, California, 90211

    Withdrawn

  • Greater Hartford Nephrology, LLC

    Bloomfield, Connecticut, 06002

    Use Central Contact

    Recruiting

  • Nephrology and Hypertension Associates

    Bluefield, West Virginia, 24701

    Use Central Contact

    Recruiting

  • - Boca Raton Regional - Research Physicians Network Alliance

    Boca Raton, Florida, 33431

    Use Central Contact

    Recruiting

  • Tufts Medical Center

    Boston, Massachusetts, 02111

    Recruiting

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114

    Trial Information Contact, 617-724-8839, hbouchouari@mgh.harvard.edu

    Recruiting

  • Nova Clinical Research, LLC

    Bradenton, Florida, 34209

    Trial Information Contact, 941-792-6564, sade.andrews@novaclinicalresearch.com

    Recruiting

  • Southwest Mississippi Nephrology PLLC

    Brookhaven, Mississippi, 39601

    Completed

  • SUNY Downstate Medical Center Brooklyn

    Brooklyn, New York, 11203

    Recruiting

  • Access Research Institute

    Brooksville, Florida, 34613

    Withdrawn

  • Coastal Medical Research, LLC

    Brunswick, Georgia, 31520

    Use Central Contact

    Recruiting

  • Metrolina Nephrology Associates, PA

    Charlotte, North Carolina, 28204

    Use Central Contact

    Recruiting

  • Southeast Renal Research Institute

    Chattanooga, Tennessee, 37404

    Trial Information Contact, 423-826-8003, dbunten@nephassociates.com

    Recruiting

  • DCR-Norfolk Great Bridge

    Chesapeake, Virginia, 23320

    Trial Information Contact, 757-636-0220, brandy.clayton@davita.com

    Recruiting

  • California Institute of Renal Research

    Chula Vista, California, 91910

    Use Central Contact

    Recruiting

  • Mattoo & Bhat Medical Associates, P.C.

    College Point, New York, 11356

    Use Central Contact

    Recruiting

  • Columbia Nephrology

    Columbia, South Carolina, 29203

    Use Central Contact

    Recruiting

  • Renal Associates LLC

    Columbus, Georgia, 31904

    Use Central Contact

    Recruiting

  • Nephrology Associates, PC

    Columbus, Mississippi, 39705

    Use Central Contact

    Recruiting

  • HNC Dialysis, Ltd.

    Columbus, Ohio, 43215

    Use Central Contact

    Recruiting

  • Horizon Research Group LLC

    Coral Gables, Florida, 33134

    Withdrawn

  • South Florida Nephrology Group, PA

    Coral Springs, Florida, 33071

    Use Central Contact

    Recruiting

  • National Clinical Trials

    Cordele, Georgia, 31015

    Recruiting

  • Dallas V.A. Medical Center

    Dallas, Texas, 75216

    Recruiting

  • Dallas Nephrology Associates

    Dallas, Texas, 75234

    Recruiting

  • US Renal Care

    Dallas, Texas, 75237

    Use Central Contact

    Recruiting

  • Nephrology of North Alabama

    Decatur, Alabama, 35601

    Recruiting

  • Kidney Associates of Colorado, P.C.

    Denver, Colorado, 80210

    Use Central Contact

    Recruiting

  • Colorado Kidney Care

    Denver, Colorado, 80230

    Use Central Contact

    Recruiting

  • American Clinical Trials

    Douglasville, Georgia, 30101

    Use Central Location

    Recruiting

  • Durham Nephrology Associates, PA

    Durham, North Carolina, 27704

    Use Central Contact

    Recruiting

  • Duke Translational Medicine Institute

    Durham, North Carolina, 27705

    Recruiting

  • Lifespan Clinical Research

    East Providence, Rhode Island, 02915

    Recruiting

  • Hypertension & Nephrology Association

    Eatontown, New Jersey, 07724

    Use Central Contact

    Recruiting

  • Davita Clinical Research

    El Paso, Texas, 79925

    Use Central Contact

    Recruiting

  • DaVita Clinical Research - Horizon

    El Paso, Texas, 79935

    Use Central Contact

    Recruiting

  • Clinical Renal Associates, LTD

    Exton, Pennsylvania, 19341

    Recruiting

  • Nephrology Associates of Northern Virginia Inc

    Fairfax, Virginia, 22033

    Trial Information Contact, 703-961-0488 ext. 120, musirah.khan@nanvonline.com

    Recruiting

  • NANI Research

    Fort Wayne, Indiana, 46804

    Trial Information Contact

    Recruiting

  • Fort Worth Renal Group

    Fort Worth, Texas, 76110

    Use Central Contact

    Recruiting

  • The Medical Research Group, Inc.

    Fresno, California, 93720

    Recruiting

  • Davita Fullerton Dialysis Center

    Fullerton, California, 92832

    Use Central Contact

    Recruiting

  • National Institute of Clinical Research, Inc.

    Fullerton, California, 92835

    Use Central Contact

    Recruiting

  • U.S. Renal Care - Gallup

    Gallup, New Mexico, 87301

    Recruiting

  • National Institute of Clinical Research, Inc.

    Garden Grove, California, 92843

    Use Central Contact

    Recruiting

  • St. Jude Medical Center

    Garden Grove, California, 92843

    Use Central Contact

    Recruiting

  • National Institute of Clinical Research

    Garden Grove, California, 92844

    Use Central Contact

    Recruiting

  • AKDHC Medical

    Glendale, Arizona, 85305

    Use Central Contact

    Recruiting

  • Kidney Disease Medical Group

    Glendale, Arizona, 91206

    Use Central Contact

    Recruiting

  • Sherman Medical Group, Inc

    Glendale, California, 91204

    Use Central Contact

    Recruiting

  • Kidney Disease Medical Group

    Glendale, California, 91206

    Use Central Contact

    Recruiting

  • Renal Consultants Medical Group

    Granada Hills, California, 91344

    Use Central Contact

    Recruiting

  • East Carolina University

    Greenville, North Carolina, 27858

    Use Central Contact

    Recruiting

  • CN Clinical Research LLC

    Greenville, South Carolina, 29605

    Recruiting

  • Peninsula Kidney Associates

    Hampton, Virginia, 23666

    Trial Information Contact, 757-637-7848, ykireeva@pen-kid.com

    Recruiting

  • DaVita Clinical Research - Henderson

    Henderson, Nevada, 89074

    Use Central Contact

    Recruiting

  • Family First Medical Research Center

    Hialeah Gardens, Florida, 33016

    Use Central Contact

    Recruiting

  • Advanced Medical Research Group

    Hollywood, Florida, 33021

    Use Central Contact

    Recruiting

  • Royal Research, Corp

    Hollywood, Florida, 33021

    Recruiting

  • Elixia Pines

    Hollywood, Florida, 33024

    Use Central Contact

    Recruiting

  • Clinical Research Strategies

    Houston, Texas, 77030

    Trial Information Contact

    Recruiting

  • DaVita Clinical Research

    Houston, Texas, 77054

    Use Central Contact

    Recruiting

  • Aqua Research Institute

    Houston, Texas, 77058

    Use Central Contact

    Recruiting

  • Gulf Coast Clinical Research

    Houston, Texas, 77070

    Recruiting

  • Houston Medical Research Institute, LLC

    Houston, Texas, 77074

    Use Central Contact

    Recruiting

  • Clinical Research Strategies, Inc.

    Houston, Texas, 77090

    Use Central Contact

    Recruiting

  • Southwest Houston Research

    Houston, Texas, 77099

    Use Central Contact

    Recruiting

  • Nephrology Consultants, LLC

    Huntsville, Alabama, 35805

    Use Central Contact

    Recruiting

  • New Jersey Kidney Care

    Jersey City, New Jersey, 07305

    Use Central Contact

    Recruiting

  • Paragon Health, Inc

    Kalamazoo, Michigan, 49007

    Use Central Contact

    Recruiting

  • Clinical Research Consultants

    Kansas City, Missouri, 64111

    Use Central Contact

    Recruiting

  • Kansas City VA Medical Center

    Kansas City, Missouri, 64128

    Recruiting

  • DCI-Rockhill

    Kansas City, Missouri, 64131

    Use Central Contact

    Recruiting

  • Eastern Nephrology Associates, PLLC

    Kinston, North Carolina, 28504

    Withdrawn

  • Dialysis Clinic Inc - University Nephology

    Knoxville, Tennessee, 37920

    Use Central Contact

    Recruiting

  • Knoxville Kidney Center PLLC

    Knoxville, Tennessee, 37923

    Use Central Contact

    Recruiting

  • Balboa Research

    La Jolla, California, 92037

    Trial Information Contact

    Recruiting

  • California Institute of Renal Research

    La Mesa, California, 91942

    Use Central Contact

    Recruiting

  • Southern California Medical Research Center

    La Palma, California, 90623

    Use Central Contact

    Recruiting

  • Laguna Clinical Research Associates, LLC

    Laredo, Texas, 78041

    Withdrawn

  • Kidney Specialists of Southern Nevada

    Las Vegas, Nevada, 89106

    Use Central Contact

    Recruiting

  • South Florida Research Institute

    Lauderdale Lakes, Florida, 33313

    Use Central Contact

    Recruiting

  • Georgia Nephrology

    Lawrenceville, Georgia, 30046

    Trial Information Contact, 404-664-7631, afelder@nephronet.com

    Recruiting

  • GSR Enterprises, Inc.

    Lincoln, Nebraska, 68510

    Use Central Contact

    Recruiting

  • Academic Medical Research Institute

    Los Angeles, California, 90022

    Use Central Contact

    Recruiting

  • National Institute of Clinical Research, Inc.

    Los Angeles, California, 90027

    Use Central Contact

    Recruiting

  • DaVita Carabello Dialysis Center

    Los Angeles, California, 90033

    Suspended

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048

    Recruiting

  • Nephrology Associates of Kentuckiana, PSC

    Louisville, Kentucky, 40205

    Use Central Contact

    Recruiting

  • Renal Medical Associates/NARI

    Lynwood, California, 90262

    Use Central Contact

    Recruiting

  • Prime Clinical Research, Inc.

    Mansfield, Texas, 76063

    Use Central Contact

    Recruiting

  • Gamma Medical Research, Inc.

    McAllen, Texas, 78503

    Use Central Location

    Recruiting

  • South Florida Research Organization LLC

    Medley, Florida, 33166

    Use Central Contact

    Recruiting

  • Lt. Col. Luke Weathers, Jr. VA Medical Center

    Memphis, Tennessee, 38105

    Recruiting

  • Aviva Health Sciences

    Miami, Florida, 33125

    Recruiting

  • Iconic Clinical Research Center

    Miami, Florida, 33126

    Use Central Contact

    Recruiting

  • Total Research Group, LLC

    Miami, Florida, 33126

    Use Central Contact

    Recruiting

  • Kidney and Hypertension Specialists of Miami

    Miami, Florida, 33150

    Withdrawn

  • Nephrology Associates of South Miami

    Miami, Florida, 33173

    Use Central Contact

    Recruiting

  • Floridian Clinical Research

    Miami Lakes, Florida, 33016

    Use Central Contact

    Recruiting

  • Nephrology and Hypertension Associates PC

    Middlebury, Connecticut, 06762

    Use Central Contact

    Recruiting

  • NYU Langone Hospital - Long Island

    Mineola, New York, 11501

    Use Central Contact

    Recruiting

  • DCR Edina

    Minneapolis, Minnesota, 55404

    Completed

  • DCR Edina

    Minneapolis, Minnesota, 55404

    Use Central Contact

    Recruiting

  • Minneapolis VA Health Care System

    Minneapolis, Minnesota, 55439

    Recruiting

  • Nephrology Physician's LLC

    Mishawaka, Indiana, 46545

    Use Central Contact

    Recruiting

  • DaVita Clinical Research Montgomery

    Montgomery, Alabama, 36117

    Use Central Contact

    Recruiting

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232

    Recruiting

  • Nephrology Associates (Delaware)

    Newark, Delaware, 19713

    Withdrawn

  • Tidewater Kidney Specialists

    Norfolk, Virginia, 23502

    Trial Information Contact, 757-374-7186, gladys.caro-espinal@davita.com

    Recruiting

  • Great Plains Health - Nephrology

    North Platte, Nebraska, 69101

    Use Central Contact

    Recruiting

  • Amicis Research Center

    Northridge, California, 91324

    Use Central Contact

    Recruiting

  • Elixia Central Florida

    Orlando, Florida, 32806

    Withdrawn

  • FORMAT Medical Research

    Oxnard, California, 93036

    Use Central Contact

    Recruiting

  • AKDHC Medical

    Phoenix, Arizona, 85018

    Use Central Contact

    Recruiting

  • National Institute of Clinical Research, Inc.

    Pomona, California, 91768

    Recruiting

  • Michigan Kidney Consultants, PC

    Pontiac, Michigan, 48341

    Use Central Contact

    Recruiting

  • Seacoast Kidney and Hypertension Specialists

    Portsmouth, New Hampshire, 03801

    Use Central Contact

    Recruiting

  • North Carolina Nephrology, PA

    Raleigh, North Carolina, 27610

    Use Central Location

    Recruiting

  • Sierra Nevada Specialty Care

    Reno, Nevada, 89511

    Use Central Contact

    Recruiting

  • Richmond V.A. Medical Center

    Richmond, Virginia, 23249

    Recruiting

  • Van Buren Dialysis Center

    Riverside, California, 92504

    Use Central Contact

    Recruiting

  • National Nephrology Alliance Research - Riverside

    Riverside, California, 92505

    Use Central Contact

    Recruiting

  • St. Clair Nephrology Research

    Roseville, Michigan, 48066

    Use Central Contact

    Recruiting

  • Center for Advanced Kidney Research, PLC

    Saint Clair Shores, Michigan, 48081

    Use Central Contact

    Recruiting

  • Central Coast Nephrology Medical Corp

    Salinas, California, 93901

    Use Central Contact

    Recruiting

  • National Institute of Clinical Research, Inc.

    San Antonio, Texas, 78204

    Use Central Contact

    Recruiting

  • DaVita Clinical Research

    San Antonio, Texas, 78229

    Use Central Contact

    Recruiting

  • Davita Clinical Research

    San Antonio, Texas, 78251

    Use Central Contact

    Recruiting

  • DCR-San Antonio Stone Oak

    San Antonio, Texas, 78258

    Use Central Contact

    Recruiting

  • California Institute of Renal Research

    San Diego, California, 92111

    Use Central Contact

    Recruiting

  • California Institute of Renal Research

    San Diego, California, 92123

    Suspended

  • North America Research Institute

    San Dimas, California, 91773

    Use Central Contact

    Recruiting

  • Satellite Healthcare

    San Jose, California, 95126

    Suspended

  • Infigo Clinical Research LLC

    Sanford, Florida, 32771

    Recruiting

  • Nephrology Associates of the Carolinas

    Shelby, North Carolina, 28150

    Recruiting

  • DaVita Clinical Research North Houston

    Shenandoah, Texas, 77384

    Use Central Contact

    Recruiting

  • Medrasa Clinical Research

    Sherman, Texas, 75092

    Trial Information Contact

    Recruiting

  • Dunes Clinical Research LLC

    Sioux City, Iowa, 57049

    Use Central Contact

    Recruiting

  • Dialysis Clinic, Inc.

    Spartanburg, South Carolina, 29301

    Trial Information Contact

    Recruiting

  • DaVita Clinical Research

    Spartanburg, South Carolina, 29306

    Use Central Contact

    Recruiting

  • Atekha Nephrology Clinic LLC

    Statesboro, Georgia, 30458

    Completed

  • Genesis Clinical Research

    Tampa, Florida, 33603

    Suspended

  • Nephrology Educational Services

    Tarzana, California, 91356

    Use Central Contact

    Recruiting

  • Valiance Clinical Research

    Tarzana, California, 91356

    Use Central Contact

    Recruiting

  • Florida Kidney Specialists

    Temple Terrace, Florida, 33637

    Use Central Contact

    Recruiting

  • DaVita Clinic Research Bronx

    The Bronx, New York, 10461

    Completed

  • Albert Einstein College of Medicine - Montefiore Medical Center

    The Bronx, New York, 10467

    Use Central Contact

    Recruiting

  • James J Peters VA Medical Center

    The Bronx, New York, 10468

    Recruiting

  • Renal Research of Montgomery County

    The Woodlands, Texas, 77384

    Trial Information Contact

    Recruiting

  • AKDHC Medical

    Tucson, Arizona, 85705

    Use Central Contact

    Recruiting

  • Southern Arizona VA Health Care System

    Tucson, Arizona, 85723

    Trial Information Contact

    Recruiting

  • - Nephrology and Hypertension Associates Ltd

    Tupelo, Mississippi, 38801

    Use Central Contact

    Recruiting

  • Amicis Research Center

    Vacaville, California, 95687

    Withdrawn

  • National Institute of Clinical Research, Inc

    Victorville, California, 92392

    Use Central Contact

    Recruiting

  • DaVita Vista Del Sol Dialysis

    Victorville, California, 92394

    Use Central Contact

    Recruiting

  • Kansas Nephrology Physicians, PA

    Wichita, Kansas, 67214

    Use Central Contact

    Recruiting

  • Florida Premier Research Institute

    Winter Park, Florida, 32789

    Use Central Contact

    Recruiting

Other trials in United States

China41 sites, 39 recruiting

  • Inner Mongolia Baotou City Central Hospital (Baotou Central Hospital)

    Baotou Shi, 14040

    Recruiting

  • Peking University People's Hospital

    Beijeing, 100033

    Recruiting

  • Peking University First Hospital

    Beijing, 100034

    Use Central Contact

    Recruiting

  • China Rehabilitation Research Center (Beijing Boai Hospital)

    Beijing, 100068

    Recruiting

  • Peking University Third Hospital

    Beijing, 100191

    Recruiting

  • Beijing Miyun Hospital

    Beijing, 101500

    Recruiting

  • Beijing Tsinghua Chang Gung Hospital

    Beijing, 102218

    Trial Information Contact

    Recruiting

  • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (SAMSPH)

    Chengdu, 610072

    Recruiting

  • The Affiliated Zhongshan Hospital (Dalian Railroad Hospital)

    Dalian, 116001

    Recruiting

  • People's Hospital of Deyang

    Deyang Shi, 618000

    Trial Information Contact

    Recruiting

  • Dongguan People's Hospital

    Dongguan, 523059

    Recruiting

  • The First People's Hospital - Foshan

    Foshan Shi, 528000

    Recruiting

  • The Fifth Affiliated Hospital of Guangzhou Medical University

    Guangzhou, 510700

    Recruiting

  • Anhui Medical University-The Second Hospital

    Hefei, 230601

    Trial Information Contact

    Recruiting

  • The First Hospital of Jiaxing

    Jiaxing, 314001

    Recruiting

  • Jiangsu Province Hospital /The First Affiliated Hospital with Nanjing Medical University

    Lanzhou, 210029

    Recruiting

  • Gansu Provincial People's Hospital

    Lanzhou, 730000

    Trial Information Contact

    Recruiting

  • Henan University of Science and Technology-The First Affiliated Hospital

    Luoyang Shi, 471003

    Recruiting

  • The Third Hospital of Mianyang

    Mianyang, 621000

    Recruiting

  • Nanchang University - The First Affiliated Hospital

    Nanchang, 330006

    Trial Information Contact

    Recruiting

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, 210003

    Recruiting

  • Jiangsu Province Hospital of Chinese Medicine

    Nanjing, 210029

    Recruiting

  • The People's Hospital Guangxi Zhuang of Autonomous Region

    Nanning, 530021

    Trial Information Contact

    Recruiting

  • Southern Medical University - Jiangxi Pingxiang People's Hospital

    Pingxiang, 337055

    Trial Information Contact

    Recruiting

  • Shanghai Jiao Tong University School of Medicine (SJTUSM)-Renji Hospital

    Shanghai, 200001

    Trial Information Contact

    Recruiting

  • Shanghai First People's Hospital

    Shanghai Shi, 200080

    Trial Information Contact

    Recruiting

  • Shenzhen Second People's Hospital (Shenzhen University First Affiliated Hospital)

    Shenzhen, 518035

    Withdrawn

  • Shijiazhuang People's Hospital

    Shijiazhuang, 050011

    Trial Information Contact

    Recruiting

  • The Fourth Hospital of Hebei Medical University

    Shijiazhuang, 50011

    Recruiting

  • Second Hospital of Shanxi Medical University

    Taiyuan, 030001

    Trial Information Contact

    Recruiting

  • Tianjin People's Hospital

    Tianjin, 300071

    Trial Information Contact

    Recruiting

  • Huazhong University of Science and Technology - Tongji Medical College - The Central Hospital of Wuhan (Wuhan Second Hospital)

    Wuhan, 430014

    Trial Information Contact

    Recruiting

  • Renmin Hospital of Wuhan University/Hubei General Hospital

    Wuhan, 430060

    Recruiting

  • Wuxi People's Hospital

    Wuxi, 214023

    Trial Information Contact

    Recruiting

  • Zhongshan Hospital Xiamen University

    Xiamen, 361004

    Trial Information Contact

    Recruiting

  • Yan'an University Xianyang Hospital

    Xianyang, 712099

    Trial Information Contact

    Recruiting

  • Xinxiang City First People's Hospital

    Xinxiang, 453000

    Trial Information Contact

    Recruiting

  • Northern Jiangsu People's Hospital

    Yangzhou, 225001

    Withdrawn

  • Yibin Second People's Hospital

    Yibin, 644000

    Trial Information Contact

    Recruiting

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, 450052

    Recruiting

  • Affiliated Hospital of Jiangsu University

    Zhenjiang, 212001

    Use Central Contact

    Recruiting

Other trials in China

Japan36 sites, 34 recruiting

  • Matsunami General Hospital

    Hashima-gun, 501-6062

    Use Central Contact

    Recruiting

  • Ishikiriseiki Hospital

    Higashiosaka-shi, 579-8026

    Use Central Contact

    Recruiting

  • NHO Hiroshimanishi Medical Center

    Hiroshima, 739-0696

    Recruiting

  • Miki Internal Medicine Urology Clinic

    Hokkaido, 041-1121

    Use Central Contact

    Recruiting

  • University of Tsukuba - Mito Kyodo General Hospital

    Ibaraki, 310-0015

    Recruiting

  • Daiyukai Daiichi Hospital

    Ichinomiya-shi, Aichi-ken, 491-8551

    Use Central Contact

    Recruiting

  • Tokyo Medical University Ibaraki Medical Center

    Inashiki-gun, 300-0332

    Use Central Contact

    Recruiting

  • Ueyama Hospital

    Kagoshima, 890-0073

    Use Central Location

    Recruiting

  • Ueyama Jin Clinic

    Kagoshima, 890-0073

    Withdrawn

  • Shonan Kamakura General Hospital

    Kamakura-Shi, 247-8533

    Recruiting

  • National Hospital Organization Kanazawa Medical Center

    Kanazawa, 920-8650

    Recruiting

  • Steel Memorial Yawata Hospital

    Kitakyushu-shi, Fukuoka, 805-0050

    Use Central Contact

    Recruiting

  • Kokura Memorial Hospital

    Kitakyushu-Shi, 802-8555

    Recruiting

  • Kurume University Hospital

    Kurume, 830-0011

    Withdrawn

  • St. Mary's Hospital

    Kurume-shi, 830-8543

    Use Central Contact

    Recruiting

  • Omi freai Hospital

    Kusatsu-shi, Shiga, 525-8585

    Use Central Contact

    Recruiting

  • Rakuwakai Otowa Kinen Hospital

    Kyoto, 607-8116

    Use Central Contact

    Recruiting

  • Maebashi Hirosegawa Clinic

    Maebashi, Gunma, 371-0022

    Use Central Contact

    Recruiting

  • Joumou Ohashi Clinic

    Maebashi, Gunma, 371-0046

    Use Central Contact

    Recruiting

  • Matsubara Tokushukai Hospital

    Matsubara-shi, 580-0032

    Recruiting

  • Nagaoka Red-Cross Hospital

    Nagaoka-Shi, 940-2085

    Use Central Contact

    Recruiting

  • Chubu Rosai Hospital

    Nagoya, 455-8530

    Use Central Contact

    Recruiting

  • Daido Hospital

    Nagoya, 457-8511

    Use Central Contact

    Recruiting

  • Ogaki Tokushukai Hospital

    Ogaki-Shi, 503-0015

    Recruiting

  • Omihachiman Community Medical Center - Kidney Center

    Ōmihachiman, 523-0082

    Use Central Contact

    Recruiting

  • Oguranaika Jin Cinic

    Oyama-shi, 323-0831

    Use Central Contact

    Recruiting

  • Ibaraki Seinan Medical Center Hospital

    Sakaimachi, 306-0433

    Use Central Contact

    Recruiting

  • Teine Urological Clinic

    Sapporo, Hokkaido, 006-0816

    Use Central Contact

    Recruiting

  • Tokyo Womens Med University

    Shinjuku-Ku, Tokyo, 162-8666

    Use Central Contact

    Recruiting

  • Kurosawa Hospital

    Takasaki-Shi, 370-1203

    Use Central Contact

    Recruiting

  • Kikuchi Medical Clinic

    Tsukuba, 305-0861

    Use Central Contact

    Recruiting

  • St.Hill Hospital

    Ube-shi, 755-0155

    Use Central Contact

    Recruiting

  • Juntendo University Urayasu Hospital

    Urayasu-shi, Chiba, 279-0021

    Use Central Contact

    Recruiting

  • Yamagata Tokushukai Hospital

    Yamagata, 990-0834

    Recruiting

  • Bosei Kannai Clinic

    Yokohama, 231-0048

    Use Central Contact

    Recruiting

  • Sanin Rosai Hospital

    Yonago-shi, 683-8605

    Use Central Contact

    Recruiting

Other trials in Japan

Italy29 sites, 24 recruiting

  • Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi

    Bologna, 40138

    Recruiting

  • ASST degli Spedali Civili di Brescia

    Brescia, 25123

    Use Central Contact

    Recruiting

  • Azienda Ospedaliera Brotzu

    Cagliari, 9100

    Recruiting

  • Azienda Ospedaliera Sant'Anna e San Sebastiano di Caserta

    Caserta, 81100

    Use Central Contact

    Recruiting

  • AOU Policlinico G Rodolico - San Marco - Presidio Ospedaliero ospedale San Marco

    Catania, 95121

    Trial Information Contact

    Recruiting

  • Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant'Anna

    Ferrara, 44124

    Withdrawn

  • Ospedale Santa Maria Annunziata

    Florence, 50012

    Use Central Contact

    Recruiting

  • A. O. -Universitaria Ospedali Riuniti di Foggia Farmacia Osp

    Foggia, 71122

    Use Central Contact

    Recruiting

  • IRCCS Az. Osp. Universitaria San Martino- IST

    Genova, 16132

    Withdrawn

  • Vito Fazzi Hospital in Lecce

    Lecce, 73100

    Withdrawn

  • ASST di Lecco - Presidio Ospedaliero A. Manzoni di Lecco

    Lecco, 23900

    Use Central Contact

    Recruiting

  • Università degli Studi di Messina

    Messina, 98124

    Use Central Contact

    Recruiting

  • ASST Santi Paolo e Carlo - Ospedale San Carlo Borromeo

    Milan, 20142

    Trial Information Contact

    Recruiting

  • IRCCS Ospedale San Raffaele

    Milan, 20132

    Withdrawn

  • ASST Great Metropolitan Hospital Niguarda

    Milan, 20162

    Recruiting

  • AOU L. Vanvitelli Universita degli Studi della Campania Luigi Vanvitelli

    Naples, 80138

    Recruiting

  • Ospedale Maggiore di Novara

    Novara, 28100

    Use Central Contact

    Recruiting

  • ICS Maugeri S.p.A. SB; Università di Pavia; Fondazione Salvatore Maugeri IRCCS

    Pavia, 2700

    Use Central Contact

    Recruiting

  • University of Verona

    Peschiera del Garda, 37019

    Use Central Contact

    Recruiting

  • AUSL Piacenza Hospital-Unit Nephrology Dialysis, Dept of Medicine

    Piacenza, 29121

    Trial Information Contact

    Recruiting

  • Azienda Ospedaliero Universitaria Pisana - Ospedale di Cisanello - Stabilimento Ospedaliero di Cisanello

    Pisana, 56124

    Recruiting

  • Ospedale Santo Stefan

    Prato, 59100

    Use Central Contact

    Recruiting

  • Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli

    Reggio Calabria, 89124

    Trial Information Contact

    Recruiting

  • Rimini Hospital

    Rimini, 47923

    Use Central Contact

    Recruiting

  • Policlinico A. Gemelli Universitario

    Roma, 168

    Recruiting

  • Azienda Unita Sanitaria Locale (USL) Roma 3 (AUSL RM 3) - Presidio Ospedaliero Giovan Battista Grassi

    Rome, 00122

    Withdrawn

  • Sandro Pertini Hospital

    Rome, 1577

    Recruiting

  • Ospedale Casa Sollievo della Sofferenza (CSS)

    San Giovanni Rotondo, 71013

    Use Central Contact

    Recruiting

  • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento

    Verona, 37126

    Use Central Contact

    Recruiting

Other trials in Italy

Brazil23 sites, 23 recruiting

  • Santa Casa de Misericordia de Belo Horizonte

    Belo Horizonte, 30150-320

    Recruiting

  • NUPEC-Nucleo de Pesquisa Clinica

    Belo Horizonte, 30220-140

    Recruiting

  • Hospital Universitário Walter Cantídio (Fortaleza)

    Fortaleza, 60430-372

    Recruiting

  • Empresa Brasileira de Serviços Hospitalares (EBSERH)

    Goiânia, 74605-020

    Recruiting

  • Fundacao Pro Rim de Santa Catarina

    Joinville, 89227-680

    Recruiting

  • Clipem - Clínica o Pesquisa Endocrinológica de Maringá

    Maringá, 87060-040

    Recruiting

  • Instituto Atena de Pesquisa Clinica

    Natal, 59020500

    Recruiting

  • Hospital de Clinicas de Passo Fundo

    Passo Fundo, 9910-260

    Recruiting

  • Irmandade Santa Casa de Misericordia de Porto Alegre

    Porto Alegre, 90035-074

    Recruiting

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, 90035-903

    Recruiting

  • Hospital São Lucas da PUCRS

    Porto Alegre, 90610-001

    Recruiting

  • CEDOES - Centro de Diagnostico e Pesquisa

    Praia Do Canto, 29055-450

    Recruiting

  • Universidade de Sao Paulo (USP)-Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto (HCFMRP)

    Ribeirão Preto, 14015-130

    Recruiting

  • SERVIÇO DE NEFROLOGIA DE RIBEIRÃO Preto (SENERP)

    Ribeirão Preto, 14025-170

    Recruiting

  • Secretaria da Saúde do Estado da Bahia (SESAB)

    Salvador, 40321-210

    Recruiting

  • Clinica Senhor do Bonfim Ltda (CSB) - Monte Serrat

    Salvador, 40415-065

    Recruiting

  • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto

    São José do Rio Preto, 15090-000

    Recruiting

  • Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo

    São Paulo, 01246-903

    Recruiting

  • Hospital Alemao Oswaldo Cruz

    São Paulo, 01323-020

    Recruiting

  • Hospital do Rim e Hipertensão

    São Paulo, 04024-002

    Recruiting

  • Trialstar-Centro de Pesquisa Clinicas

    São Paulo, 05690040-903

    Recruiting

  • Hospital Santa Marcelina

    São Paulo, 08270-070

    Recruiting

  • Hospital 9 de Julho

    São Paulo, 1409-902

    Recruiting

Other trials in Brazil

Spain21 sites, 19 recruiting

  • Centro de dialisis Alcobendas

    Alcobendas, 28100

    Recruiting

  • Hospital Universitari de Bellvitge (IDIBELL)

    Barcelona, 08907

    Recruiting

  • Hospital Universitario Valle de Hebron

    Barcelona, 8035

    Recruiting

  • University Hospital Reina Sofía

    Córdoba, 14005

    Recruiting

  • Hospital Universitari de Girona Dr Josep Trueta, (Avitum)

    Girona, 17007

    Trial Information Contact

    Recruiting

  • Hospital Universitario Virgen de las Nieves

    Granada, 18014

    Recruiting

  • Universidad de Alcala (UAH)

    Guadalajara, 19002

    Withdrawn

  • Hospital Universitari Arnau de Vilanova

    Lleida, 25198

    Use Central Contact

    Recruiting

  • Hospital Universitario de La Princesa

    Madrid, 28006

    Recruiting

  • Universitario Gregorio Marañón

    Madrid, 28007

    Recruiting

  • Hospital Clínico San Carlos

    Madrid, 28040

    Recruiting

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040

    Recruiting

  • Hospital Universitario Príncipe de Asturias

    Madrid, 28806

    Recruiting

  • Hospital de Manises

    Manises, 46940

    Trial Information Contact

    Recruiting

  • Hospital Universitari Son Espases

    Palma de Mallorca, 7120

    Recruiting

  • CHUS - H. Clinico U. de Santiago

    Santiago de Compostela, 15706

    Recruiting

  • Hospital Universitario Virgen de la Macarena

    Seville, 41009

    Recruiting

  • Fresenius Medical Care Centro de Diálisis Terrassa

    Terrassa, 8223

    Withdrawn

  • Hospital Clinico Universitario - Valencia

    Valencia, 46010

    Trial Information Contact

    Recruiting

  • Centro Hospital Universitario Dr. Preset

    Valencia, 46017

    Recruiting

  • Hospital Universitari i Politècnic La Fe

    Valencia, 46026

    Trial Information Contact

    Recruiting

Other trials in Spain

Australia18 sites, 15 recruiting

  • Wide Bay Hospital and Health Service

    Bundaberg, 4670

    Withdrawn

  • Cairns Hospital

    Cairns, Queensland, 4870

    Use Central Contact

    Recruiting

  • Monash Medical Centre

    Clayton, Victoria, 3168

    Use Central Contact

    Recruiting

  • Austin Hospital

    Heidelberg, 3084

    Trial Information Contact

    Recruiting

  • Liverpool Hospital

    Liverpool, 2170

    Recruiting

  • Fiona Stanley Hospital

    Murdoch, 6150

    Use Central Contact

    Recruiting

  • Sunshine Coast University Private Hospital

    Nambour, Queensland, 4560

    Suspended

  • Sunshine Coast University Private Hospital

    Nambour, 4560

    Use Central Contact

    Recruiting

  • Royal Melbourne Hospital

    Parkville, 3052

    Trial Information Contact

    Recruiting

  • Royal North Shore Hospital (RNSH)

    Saint Leonards, New South Wales, 2065

    Use Central Contact

    Recruiting

  • Gold Coast University Hospital

    Southport, 4215

    Use Central Contact

    Recruiting

  • Sunshine Hospital

    St Albans, Victoria, 3021

    Use Central Contact

    Recruiting

  • Concord Repatriation General Hospital

    Sydney, New South Wales, 2139

    Use Central Contact

    Recruiting

  • Fraser Coast Renal Service, Hervey Bay Hospital

    Urraween, 4655

    Trial Information Contact

    Recruiting

  • Sydney Adventist Hospital

    Wahroonga, 2076

    Trial Information Contact

    Recruiting

  • Westmead Hospital

    Westmead, 2145

    Use Central Contact

    Recruiting

  • Wollongong Renal Unit

    Wollongong, 2500

    Use Central Contact

    Recruiting

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102

    Suspended

Other trials in Australia

France18 sites, 14 recruiting

  • CHU Amiens - Nephrology Dialysi Transplantation Department

    Amiens, 80054

    Use Central Contact

    Recruiting

  • CHU de Saint-Étienne - Hôpital Nord

    Aura, 42055

    Use Central Contact

    Recruiting

  • Centre Hospitalier Regional Universitaire (CHRU) Brest - Hopital de la Cavale Blanche

    Brest, 29200

    Withdrawn

  • CHU de Caen

    Caen, 14000

    Withdrawn

  • Polyclinique Saint Come - Centre de Dialyse

    Compiègne, 60200

    Recruiting

  • Fondation Charles Mion AIDER Santé

    Grabels, 34790

    Trial Information Contact

    Recruiting

  • Hopital Prive La Louviere

    Lille, 59000

    Withdrawn

  • CHU de Limoges

    Limoges, 87042

    Use Central Contact

    Recruiting

  • Hopitaux Universitaires de Marseille

    Marseille, 13005

    Withdrawn

  • Centre Hospitalier Universitaire Montpellier - Hôpital Lapeyronie

    Montpellier, 34295

    Use Central Contact

    Recruiting

  • CHE de Nice - Pasteur Hospital

    Nice, 6000

    Recruiting

  • CHU de Nimes - Hopital Universitaire Caremeau

    Nîmes, 30029

    Trial Information Contact

    Recruiting

  • Hopital Pitie-Salpetriere

    Paris, 75013

    Trial Information Contact

    Recruiting

  • AURA Paris - Plaisance

    Paris, 75014

    Use Central Contact

    Recruiting

  • Centre Hospitalier Universitaire (CHU) de Reims - Hopital Maison Blanche

    Reims, 51092

    Trial Information Contact

    Recruiting

  • AURA St Quen Dialysis centre

    Saint-Ouen, 93400

    Use Central Contact

    Recruiting

  • Hôpitaux Universitaires de Strasbourg - Hôpital Civil

    Strasbourg, 67091

    Use Central Contact

    Recruiting

  • CHU Rangueil

    Toulouse, 31059

    use Central Contact

    Recruiting

Other trials in France

Romania18 sites, 17 recruiting

  • Centrul de Dializa Fresenius NephroCare Brasov

    Brasov, 500152

    Recruiting

  • Institutul National de Diabet, Nutriţie şi Boli Metabolice - Prof. Dr. N. Paulescu - Central

    Bucharest, 020475

    Withdrawn

  • SC International Healthcare Systems SA - IHS Sf. Ioan Dialysis Center

    Bucharest, 042122

    Use Central Contact

    Recruiting

  • Centrul De Nefrologie si Dializa DIAVERUM SPLAI

    Bucharest, 060044

    Recruiting

  • Centrul de Dializa Fresenius NephroCare Bucaresti

    Bucharest, 203512

    Recruiting

  • Fundeni Clinical Institute

    Bucharest, 22328

    Use Central Contact

    Recruiting

  • Centrul de Nefrologie si Dializa DIAVERUM Sema Parc

    Bucharest, 60044

    Recruiting

  • Centrul de Nefrologie si Dializa Diaverum Fundeni

    Bucharest, 77085

    Recruiting

  • Centrul de Dializa Fresenius NephroCare Cluj

    Cluj-Napoca, 400505

    Recruiting

  • Centrul de Dializa Fresenius NephroCare Constanta

    Constanța, 900001

    Recruiting

  • Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta (Emergency Clinic Hospital Constanta)

    Constanța, 900591

    Use Central Contact

    Recruiting

  • Centrul de Nefrologie si Dializa Diaverum Craiova

    Craiova, 200349

    Recruiting

  • Spitalul Judetean de Urgenta Deva

    Deva, 33081

    Recruiting

  • Spitalul Clinic -Dr. C.I. Parhon - Iasi

    Iași, 700503

    Trial Information Contact

    Recruiting

  • Spitalul Clinic Municipal Dr. Gavril Curteanu Oradea

    Oradea, 410057

    Recruiting

  • Centrul de Dializa Fresenius NephroCare Ploiesti

    Ploieşti, 100551

    Recruiting

  • Spital Judetean de Urgenta Satu Mare

    Satu Mare, 440055

    Use Central Contact

    Recruiting

  • Centrul Medical de Nefrologie si Dializa Diaverum Targu Mures

    Târgu Mureş, 540487

    Recruiting

Other trials in Romania

Argentina16 sites, 16 recruiting

  • FME Lomas de Zamora

    Banfield, 1828

    Recruiting

  • FME Mansilla

    Buenos Aires, 1425

    Recruiting

  • Instituto de Trasplante De La Ciudad Autonoma De Buenos Aires

    Buenos Aires, 6022

    Recruiting

  • FME Avellaneda

    Buenos Aires, B1870ARU

    Recruiting

  • FME Cemic Saavedra

    Ciudad Autonoma, C1431FWO

    Recruiting

  • CEREHA

    Ciudad de Buenos Aires, C1426

    Recruiting

  • Fresenius Medical Care - Ciudad Evita

    Ciudad Evita, B1778IFA

    Recruiting

  • Clinica Privada Velez Sarsfield

    Córdoba, 5016

    Recruiting

  • FME Formosa

    Formosa, 3600

    Recruiting

  • STR Hurlingham SRL

    Hurlingham, B 1686

    Recruiting

  • Nextdial S.A.

    Mar del Plata, 7600

    Recruiting

  • Fresenius Medical Care - Nostri Centri Dialisi - Moron

    Morón, B1708DPO

    Recruiting

  • Instituto Medico de la Fundacion de Estudios Clínicos

    Rosario, S2000DEJ

    Recruiting

  • FME San Fernando

    San Fernando, 1646

    Recruiting

  • Fresenius Tucumán

    San Miguel de Tucumán, 4000

    Recruiting

  • Clínica de Nefrología, Urología y Enfermedades Cardiovasculares

    Santa Fe, S3000BPJ

    Recruiting

Other trials in Argentina

Canada16 sites, 15 recruiting

  • University of Alberta Hospital

    Edmonton, Alberta, T6G2P4

    Use Central Contact

    Recruiting

  • Queen Elizabeth II Health Sciences Centre

    Halifax, Nova Scotia, B3H 3A6

    Trial Information Contact, 1-902-473-7625, laura.sills@nshealth.ca

    Recruiting

  • St. Josephs Healthcare Hamilton

    Hamilton, Ontario, L8N 4A6

    Use Central Contact

    Recruiting

  • Kingston Health Sciences Centre

    Kingston, Ontario, K7L 2V7

    Trial Information Contact, 1-613-533-6000, muhammed.zaman@queensu.ca

    Recruiting

  • London Health Sciences Centre - University Hospital

    London, Ontario, N6A 5A5

    Use Central Contact

    Recruiting

  • Hospital Charles Lemoyne

    Longueuil, J4V 2H1

    Withdrawn

  • McGill University Health Centre

    Montreal, Quebec, H4A 3J1

    Use Central Contact

    Recruiting

  • Hôpital du Sacré-Cœur-de-Montréal

    Montreal, Quebec, H4J 1C5

    Trial Information Contact, 1-514-338-2222 ext. 1-3182, guylaine.marcotte.cnmtl@ssss.gouv.qc.ca

    Recruiting

  • Maisonneuve-Rosemont Hospital

    Montreal, H1T 2M4

    Trial Information Contact, 1-514-252-3400 ext. 3722, karine.chausse.cemtl@ssss.gouv.qc.ca

    Recruiting

  • CHUM - Centre hospitalier de l'Universite de Montreal

    Montreal, H2X 3E4

    Use Central Contact

    Recruiting

  • Lakeridge Health Oshawa

    Oshawa, Ontario, L1G 2B9

    Use Central Contact

    Recruiting

  • The Ottawa Hospital Research Institute

    Ottawa, K1H 8L6

    Recruiting

  • Ciussse-Chus

    Sherbrooke, J1H 5N4

    Trial Information Contact

    Recruiting

  • St. Michaels Hospital

    Toronto, M5B 1W8

    Use Central Contact

    Recruiting

  • St Paul Hospital

    Vancouver, V6Z 1Y6

    Trial Information Contact

    Recruiting

  • Seven Oaks Hospital

    Winnipeg, R2V 3M3

    Trial Information Contact

    Recruiting

Other trials in Canada

Greece16 sites, 15 recruiting

  • University Hospital of Alexandroupolis

    Alexandroupoli, 68100

    Use Central Contact

    Recruiting

  • General Hospital of Arta

    Arta, 471 00

    Withdrawn

  • Korgialenio-Benakio Hellenic Red Cross Hospital

    Athens, 115 26

    Recruiting

  • University General Hospital of Heraklion

    Crete, 71500

    Use Central Contact

    Recruiting

  • Mesogeios Nephrology Center

    Haidari, 12461

    Recruiting

  • University General Hospital of Ioannina

    Ioannina, 45110

    Use Central Contact

    Recruiting

  • General Hospital of Ioannina G. Hatzikosta

    Ioannina, 45445

    Use Central Contact

    Recruiting

  • Nephrological Clinic University Hospital, University of Thessaly

    Larissa, 41110

    Use Central Contact

    Recruiting

  • Mitera Hospital, Hemodialysis Unit

    Marousi, 15123

    Recruiting

  • General Hospital of Ptolemaida

    Ptolemaida, 50200

    Trial Information Contact

    Recruiting

  • University Hospital of Patras

    Rio, 265 04

    Use Central Contact

    Recruiting

  • AHEPA Univ. Hospital, Medical School, Aristotle University of Thessaloniki

    Thessaloniki, 45500

    Use Central Contact

    Recruiting

  • Aristotle University, Hippokration

    Thessaloniki, 54642

    Use Central Contact

    Recruiting

  • General Hospital of Thessaloniki, Agios Pavlos

    Thessaloniki, 55134

    Use Central Contact

    Recruiting

  • Papageorgiou General Hospital of Thessaloniki

    Thessaloniki, 56403

    Use Central Contact

    Recruiting

  • Nephrology Department G. Papanikolaou General Hospital

    Thessaloniki, 570 10

    Use Central Contact

    Recruiting

Other trials in Greece

United Kingdom15 sites, 13 recruiting

  • University Hospitals Birmingham NHS Foundation Trust - Birmingham Heartlands Hospital (BHH)

    Birmingham, B9 5SS

    Withdrawn

  • Bradford Teaching Hospitals NHS Foundation Trust

    Bradford, BD9 6RJ

    Use Central Contact

    Recruiting

  • University Hospital Coventry and Warwickshire

    Coventry, CV2 2DX

    Use Central Contact

    Recruiting

  • University Hospitals of Derby and Burton NHS Foundation Trust - Royal Derby Hospital

    Derby, DE22 3NE

    Use Central Contact

    Recruiting

  • Dorset County Hospital NHS Foundation Trust - Dorset County Hospital (DCH)

    Dorchester, DT1 2JY

    Withdrawn

  • Royal Liverpool University Hospital

    Liverpool, L7 8XP

    Use Central Contact

    Recruiting

  • William Harvey Research Institute ; Barts Health NHS Trust - The Royal London Hospital

    London, E1 1BB

    Trial Information Contact

    Recruiting

  • King´s College NHS Trust

    London, SE5 9RS

    Trial Information Contact

    Recruiting

  • St George's University Hospitals NHS Foundation Trust - St G

    London, SW17 0QT

    Use Central Contact

    Recruiting

  • Hammersmith Hospital Imperial College Healthcare NHS Trust -Hammersmith Hospital - West London Renal and Transplant Centre

    London, W12 0HS

    Trial Information Contact

    Recruiting

  • Altnagelvin Area Hospital

    Londonderry, BT47 6SB

    Use Central Contact

    Recruiting

  • Northern Care Alliance NHS Foundation Trust - Salford Royal NHS Foundation Trust-Salford Care Organisation

    Salford, M6 8HD

    Use Central Contact

    Recruiting

  • The Shrewsbury and Telford Hospital NHS Trust (SaTH) - Royal Shrewsbury Hospital

    Shrewsbury, SY3 8XQ

    Trial Information Contact

    Recruiting

  • Royal Stoke University Hospital

    Stoke-on-Trent, ST4 6QG

    Use Central Contact

    Recruiting

  • The Royal Wolverhampton NHS Trust - New Cross Hospital

    Wolverhampton, WV10 0QP

    Use Central Contact

    Recruiting

Other trials in United Kingdom

Poland13 sites, 11 recruiting

  • Davita Stacja Dializ w Brodnicy

    Brodnica, 87-300

    Recruiting

  • Slaski Uniwersytet Medyczny (SUM) w Katowicach

    Katowice, 40-027

    Recruiting

  • Davita-Łęczna

    Łęczna, 21-010

    Recruiting

  • Uniwersytecki Szpital Kliniczny Nr. 1 im. Norberta Barlickiego

    Lodz, 90-153

    Recruiting

  • Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodz, Klinika Nefrologii, Hipertensjologii i Transplantologii Nerek

    Lodz, 92-213

    Recruiting

  • Davita- Naklo n. Notecią

    Naklo N. Notecią, 89-100

    Withdrawn

  • DaVita Stacja Dializ

    Pszczyna, 43-200

    Recruiting

  • Powiatowy Szpital Specjalistyczny w Stalowej Woli

    Stalowa Wola, 37-450

    Trial Information Contact

    Recruiting

  • Samodzielny Publiczny Szpital Kliniczny Nr. 2 Pomorski Uniwersytet Medyczny w Szczecinie

    Szczecin, 70-111

    Recruiting

  • Diaverum - NZOZ Tczewie

    Tczew, 83-110

    Trial Information Contact

    Recruiting

  • DaVita Stacja Dializ

    Warsaw, 01-211

    Trial Information Contact

    Recruiting

  • Klinika Chorob Wewnetrznych, Nefrologii i Transplantologii, CSK MSWiA

    Warsaw, 02-507

    Withdrawn

  • Wojskowy Instytut Medyczny (WIM) - Centralny Szpital Kliniczny (CSK) MON - Klinika Chorob Wewnetrznych

    Warsaw, 04-349

    Recruiting

Other trials in Poland

Bulgaria12 sites, 12 recruiting

  • Multiprofile Hospital for Active Treatment - Dobrich AD

    Dobrich, 9300

    Recruiting

  • Multiprofile Hospital For Active Treatment Dr Tota Venkova

    Gabrovo, 5300

    Trial Information Contact

    Recruiting

  • Multiprofile Hospital for Active Treatment- Sveti Nikolay Chudotvoretz - LOM EOOD

    Lom, 3600

    Use Central Contact

    Recruiting

  • Dialysis Centre Montana

    Montana, 3400

    Recruiting

  • University Multiprofile Hospital for Active Treatment Sveti Georgi EAD

    Plovdiv, 4002

    Trial Information Contact

    Recruiting

  • UMHAT Plovdiv

    Plovdiv, 4003

    Trial Information Contact

    Recruiting

  • Multiprofile Hospital for Active Treatment Dr. Ivan Seliminski - Sliven AD

    Sliven, 6600

    Trial Information Contact

    Recruiting

  • Medical Center - Smolyan OOD

    Smolyan, 4700

    Use Central Contact

    Recruiting

  • UMHAT Aleksandrovska

    Sofia, 1432

    Recruiting

  • University Hospital for Active Treatment Tsaritsa Joanna ISUL EAD

    Sofia, 1527

    Recruiting

  • Dialysis Center VIA DIAL OOD

    Stara Zagora, 6000

    Use Central Contact

    Recruiting

  • UMHAT Prof. Dr. Stoyan Kirkovich

    Stara Zagora, 6000

    Trial Information Contact

    Recruiting

Other trials in Bulgaria

Portugal12 sites, 12 recruiting

  • Unidade Local de Saúde de Braga, E. P. E.

    Braga, 4710-243

    Use Central Contact

    Recruiting

  • Caledial - Centro de Hemodiálise de Gaia

    Canelas-V.N.Gaia, 4410-313

    Recruiting

  • NephroCare Carregado

    Carregado, 2580-588

    Recruiting

  • Nephrocare Faro

    Faro, 8055-546

    Recruiting

  • Centro Hospitalar e Universitário de Lisboa Centra

    Lisbon, 1050-099

    Recruiting

  • Fresenius Medical Care - NephroCare - Unidade de Hemodialise do Restelo

    Lisbon, 1400-195

    Recruiting

  • Unidade Local de Saúde de Loures -Odivelas, E. P. E.

    Loures, 2674-514

    Use Central Contact

    Recruiting

  • Unidade Local de Saúde de São José, E. P. E.

    Oeiras, 2790

    Use Central Contact

    Recruiting

  • Unidade Local de Saúde de Santo António, E. P. E.

    Porto, 4099-001

    Use Central Contact

    Recruiting

  • Fresenius NephroCare

    Porto, 4470-235

    Recruiting

  • Unidade Local de Saúde do Médio Tejo, E. P. E.

    Torres Novas, 2354-754

    Recruiting

  • Unidade Local de Saúde do Estuário do Tejo, E. P. E.

    Vila Franca de Xira, 2600-009

    Trial Information Contact

    Recruiting

Other trials in Portugal

Israel11 sites, 10 recruiting

  • Emek Medical Center

    Afula, 18105

    Withdrawn

  • Barzilai Medical Center

    Ashkelon, 7830604

    Recruiting

  • Carmel Medical Center

    Haifa, 3436212

    Use Central Contact

    Recruiting

  • Edith Wolfson Medical Center

    Holon, 58100

    Use Central Contact

    Recruiting

  • Galilee Medical Center

    Nahariya, 2244624

    Recruiting

  • Rabin Medical Center

    Petah Tikva, 4941492

    Use Central Contact

    Recruiting

  • Chaim Sheba Medical Center (Sheba Tel-Hashomer Medical Center )

    Ramat Gan, 3109601

    Use Central Contact

    Recruiting

  • Kaplan Medical Center

    Rehovot, 7661041

    Recruiting

  • Ziv Medical Center

    Safed, 13110

    Use Central Contact

    Recruiting

  • Ichilov Hospital-Tel-Aviv Sourasky Medical Center

    Tel Aviv, 84100

    Use Central Contact

    Recruiting

  • Medical Research & Development Fund for Health Services, PORIYA Hospital

    Tiberias, 15208

    Use Central Contact

    Recruiting

Other trials in Israel

Belgium10 sites, 9 recruiting

  • Onze-Lieve-Vrouwziekenhuis VZW

    Aalst, 9300

    Use Central Contact

    Recruiting

  • Imelda Ziekenhuis

    Bonheiden, 2820

    Use Central Contact

    Recruiting

  • Centre Hospitalier Universitaire (CHU) de Charleroi - Hopital Civil Marie Curie

    Charleroi, 6042

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  • AZ Sint-Lucas

    Ghent, 9000

    Suspended

  • Centre Hospitalier Universitaire de Tivoli

    La Louvière, 7100

    Use Central Contact

    Recruiting

  • Jan Yperman Ziekenhuis

    Leper, 8900

    Recruiting

  • Universitair Ziekenhuis Leuven

    Leuven, 3000

    Use Central Contact

    Recruiting

  • CHR de la Citadelle

    Liège, 4000

    Use Central Contact

    Recruiting

  • AZ Delta (H.-Hartziekenhuis Roeselare-Menen vzw (HHRM)) - Campus Rumbeke

    Roeselare, 8800

    Use Central Contact

    Recruiting

  • VITAZ, Department Nierziekten & Dialyse

    Sint-Niklaas, 9100

    Trial Information Contact

    Recruiting

Other trials in Belgium

South Korea10 sites, 6 recruiting

  • Hallym University Sacred Heart Hospital

    Anyang-si, 14068

    Use Central Contact

    Recruiting

  • Keimyung University Dongsan Medical Center

    Daegu, 42601

    Use Central Contact

    Recruiting

  • Gangnam Severance Hospital

    Gangnam-gu, 6273

    Use Central Contact

    Recruiting

  • National Health Insurance Service - Ilsan Hospital

    Goyang-si, 10444

    Withdrawn

  • Hanyang University Guri Hospital

    Guri-si, 11923

    Trial Information Contact

    Recruiting

  • Konkuk University Medical Center

    Gwangju, 5030

    Use Central Contact

    Recruiting

  • SMG - SNU Boramae Medical Center

    Ilsan-gu, Seoul, 7061

    Use Central Contact

    Recruiting

  • Seoul National University Hospital

    Seoul, 03080

    Withdrawn

  • Severance Hospital, Yonsei University

    Seoul, 03722

    Withdrawn

  • Yonsei University - Wonju Severance Christian Hospital

    Wŏnju, 26426

    Withdrawn

Other trials in South Korea

Turkey (Türkiye)10 sites, 10 recruiting

  • Hacettepe University,Faculty of Medicine

    Ankara, 6230

    Recruiting

  • Akdeniz University Medical Faculty Hospital

    Antalya, 7070

    Recruiting

  • Ondokuz Mayis Üniversitesi

    Atakum, 55280

    Recruiting

  • İstanbul Bakirköy Dr.Sadi Konuk Eğitim Araştirma Hastanesi

    Bakırköy, 34147

    Recruiting

  • Ege University Hospital

    Bornova, 35100

    Recruiting

  • Trakya Üniversitesi Tıp Fakültesi

    Edirne, 22030

    Recruiting

  • Gaziantep University

    Gaziantep, 27310

    Recruiting

  • Kocaeli University, Medical Faculty, Division of Nephrology

    İzmit, 41000

    Recruiting

  • Kahramanmaras Sutcu Imam University - Tip Fakultesi (Kahramanmaras Sutcu Imam University Faculty of Medicine)

    Kahramanmaraş, 46040

    Recruiting

  • Malatya Education and Research Hospital

    Yeşilyurt, 44000

    Recruiting

Other trials in Turkey (Türkiye)

Germany7 sites, 5 recruiting

  • Charite-Universitatsmedizin Berlin

    Berlin, 13353

    Use Central Contact

    Recruiting

  • Nierenzentrum Bad König

    Hessen, 64732

    Use Central Contact

    Recruiting

  • Westpfalz Klinikum GmbH

    Kaiserslautern, 67655

    Use Central Contact

    Recruiting

  • UKSH - Universitatsklinik Schleswig-Holstein

    Kiel, 24105

    Suspended

  • Kuratorium fuer Dialyse und Nierentransplantation e.V. - KfH-Nierenzentrum - St. Georg

    Leipzig, 04129

    Trial Information Contact

    Recruiting

  • Universitätsmedizin der Johannes Gutenberg-Universität Mainz

    Mainz, 55131

    Withdrawn

  • Nephrologisches Zentrum Villingen-Schwenningen

    Villingen-Schwenningen, 78052

    Use Central Contact

    Recruiting

Other trials in Germany

Taiwan7 sites, 7 recruiting

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807

    Recruiting

  • Jiangxi Provincial People's Hospital

    Nanchang, 330006

    Recruiting

  • The First People's Hospital of Nanning

    Nanning Shi, 530022

    Recruiting

  • Far Eastern Memorial Hospital

    New Taipei City, 220216

    Recruiting

  • Taipei Medical University Shuang Ho Hospital

    New Taipei City, 235041

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  • Taichung Veterans General Hospital

    Taichung, 40705

    Recruiting

  • Taipei Medical University - Taipei Medical University Hospital

    Taipei, 110

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Other trials in Taiwan

Malaysia6 sites, 6 recruiting

  • Hospital Raja Permaisuri Bainun, Ipoh

    Ipoh, 31400

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  • Queen Elizabeth Hospital

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    Lembah Pantai, 59100

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  • Hospital Kuala Lumpur

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  • Seberang Jaya Hospital

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Other trials in Malaysia

Czechia5 sites, 5 recruiting

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Other trials in Czechia

Denmark5 sites, 4 recruiting

  • Aalborg Universitetshospital

    Aalborg, 9000

    Use Central Contact

    Recruiting

  • Herlev Hospital

    Herlev, 2730

    Use Central Contact

    Recruiting

  • Gødstrup Hospital

    Herning, 7400

    Use Central Contact

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  • Trail Nation: Nordsjællands Hospital

    Hillerød, 3400

    Use Central Contact

    Recruiting

  • Holbæk Sygehus

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Other trials in Denmark

Hong Kong3 sites, 3 recruiting

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Other trials in Hong Kong

Netherlands3 sites, 3 recruiting

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  • Catharina hospital

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Other trials in Netherlands

Norway3 sites, 3 recruiting

  • Vestre Viken HF - Drammen Sykehus (Sykehuset Buskerud)

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    Trial Information Contact

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Other trials in Norway

Slovakia3 sites, 3 recruiting

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    Lučenec, 98401

    Trial Information Contact

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Sweden3 sites, 3 recruiting

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  • Uppsala Universitet - Akademiska Sjukhuset

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    Use Central Contact

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Other trials in Sweden

Thailand3 sites, 3 recruiting

  • Maharat Nakhon Ratchasima Hospital

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Hungary2 sites, 1 recruiting

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Other trials in Hungary

Mexico2 sites, 2 recruiting

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Austria1 site, 1 recruiting

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    Vienna, 1130

    Trial Information Contact

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Puerto Rico1 site, 1 recruiting

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About this study

Official title: A Phase 2b / 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Combined Dose-Finding and Cardiovascular Outcome Study to Investigate the Efficacy and Safety of CSL300 (Clazakizumab) in Subjects With End Stage Kidney Disease Undergoing Dialysis

This is a two-part, phase 2b and phase 3 combined prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study.

Part 1: Phase 2b is a dose-finding study for CSL300 vs placebo. Part 2: Phase 3 aims to assess the efficacy of CSL300 vs placebo on cardiovascular (CV) outcomes and safety in subjects with systemic inflammation and either atherosclerotic cardiovascular disease (ASCVD) or diabetes with end stage kidney disease (ESKD) undergoing maintenance dialysis.

Being tested
CSL300, Placebo
Keywords
End Stage Kidney Disease (ESKD), Myocardial infarction (MI), Atherosclerotic cardiovascular disease (ASCVD), Coronary artery disease, Peripheral artery disease, Diabetes
Medical subject headings
Kidney Failure, Chronic, Myocardial Infarction, Atherosclerosis, Coronary Artery Disease, Peripheral Arterial Disease, Diabetes Mellitus

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • CSL300Drug

    Also called Clazakizumab

    IV administration

  • PlaceboDrug

    Matching the excipient content and concentration of the CSL300 product, minus the active ingredient.

Study groups in NCT05485961
Study groupRoleWhat they receive
CSL300 (low dose)(Phase 2b)ExperimentalIntravenous (IV) administration
Receives: Drug: CSL300
CSL300 (medium dose)(Phase 2b)ExperimentalIV administration
Receives: Drug: CSL300
CSL300 (high dose)(Phase 2b)ExperimentalIV administration
Receives: Drug: CSL300
Placebo (Phase 2b)Placebo comparatorIV administration
Receives: Drug: Placebo
CSL300 (Phase 3)ExperimentalIV administration
Receives: Drug: CSL300
Placebo (Phase 3)Placebo comparatorIV administration
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Change from Baseline on the log scale in high-sensitivity C-reactive protein (hs-CRP)(Phase 2b)

    Measured: Baseline and up to Week 12

  2. Time to first occurrence of CV death or myocardial infarction (MI) (Phase 3)

    Measured: Approximately 5 years

Secondary outcomes (38)

  1. Percent of participants achieving hs-CRP less than (<) 2.0 milligram per Liter (mg/L) (Phase 2b)

    Measured: Week 12

  2. Change from baseline in log-transformed hs-CRP (Phase 2b)

    Measured: Baseline and up to Week 24

  3. Mean change from Baseline in serum amyloid A (SAA) (Phase 2b)

    Measured: Baseline and up to Week 12

  4. Mean change from Baseline in secretory phospholipase A2 (sPLA2) (Phase 2b)

    Measured: Baseline and up to Week 12

  5. Mean change from Baseline in fibrinogen (Phase 2b)

    Measured: Baseline and up to Week 12

  6. Mean change from Baseline in plasminogen activator inhibitor -1 (PAI-1) (Phase 2b)

    Measured: Baseline and up to Week 12

  7. Mean change from Baseline in lipoprotein (Lp) (a) (Phase 2b)

    Measured: Baseline and up to Week 12

  8. Mean change from Baseline in albumin (Phase 2b)

    Measured: Baseline and up to Week 12

  9. Mean change from Baseline in Hepcidin (Phase 2b)

    Measured: Baseline and up to Week 12

  10. Mean change from Baseline in hemoglobin (Phase 2b)

    Measured: Baseline and up to Week 12

  11. Mean change from Baseline in erythropoiesis-stimulating agents (ESA) (Phase 2b)

    Measured: Baseline and up to Week 12

  12. Mean change from Baseline in erythropoietin-resistance index (ERI) (Phase 2b)

    Measured: Baseline and up to Week 12

  13. Mean change from Baseline in iron (Phase 2b)

    Measured: Baseline and up to Week 12

  14. Mean change from Baseline in total iron binding capacity (TIBC) (Phase 2b)

    Measured: Baseline and up to Week 12

  15. Mean change from Baseline in transferrin saturation (TSAT) (Phase 2b)

    Measured: Baseline and up to Week 12

  16. Mean change from Baseline in ferritin (Phase 2b)

    Measured: Baseline and up to Week 12

  17. Area under the plasma concentration versus time curve (AUC) for CSL300 (Phase 2b)

    Measured: Up to Week 24

  18. Peak Plasma Concentration (Cmax) for CSL300 (Phase 2b)

    Measured: Up to Week 24

  19. Trough Plasma Concentration (Ctrough) for CSL300 (Phase 2b)

    Measured: Up to Week 24

  20. Time to Maximum Plasma Concentration (Tmax) for CSL300 (Phase 2b)

    Measured: Up to Week 24

  21. Percent of participants with adverse events (AE), serious AE (SAE), including adverse events of special interest (AESIs) (Phase 2b)

    Measured: Up to Week 32

  22. Mean change from Baseline in white blood cell (WBC) (Phase 2b)

    Measured: Up to Week 12

  23. Mean change from Baseline in neutrophils (Phase 2b)

    Measured: Up to Week 12

  24. Mean change from Baseline in platelets (Phase 2b)

    Measured: Up to Week 12

  25. Mean change from Baseline in aspartate aminotransferase (AST) (Phase 2b)

    Measured: Up to Week 12

  26. Mean change from Baseline in alanine aminotransferase (ALT) (Phase 2b)

    Measured: Up to Week 12

  27. Mean change from Baseline in total bilirubin (Phase 2b)

    Measured: Up to Week 12

  28. Mean change from Baseline in lipid panel (Phase 2b)

    Lipid panel consists of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride.

    Measured: Up to Week 12

  29. Titer of confirmed antibodies specific to CSL300 (Phase 2b)

    Measured: Up to Week 12

  30. Time to first occurrence of all-cause death or MI (Phase 3)

    Measured: Approximately 5 years

  31. Time to first occurrence of CV death, MI, or ischemic stroke (Phase 3)

    Measured: Approximately 5 years

  32. Time to first occurrence of CV death (Phase 3)

    Measured: Approximately 5 years

  33. Time to first occurrence of CV death, MI or major adverse limb event (Phase 3)

    Measured: Approximately 5 years

  34. Time to first occurrence of all-cause death (Phase 3)

    Measured: Approximately 5 years

  35. Time to first occurrence of CV death, MI, or hospitalization for heart failure (HF) (Phase 3)

    Measured: Up to 5 years

  36. Total number of CV hospitalizations (Phase 3)

    Measured: Approximately 5 years

  37. Total number of HF hospitalizations and urgent visits (Phase 3)

    Measured: Approximately 5 years

  38. Total number of hospitalizations (Phase 3)

    Measured: Approximately 5 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted3 Aug 2022
  2. Study start27 Apr 2024
  3. Primary completion22 May 2029 (estimated)
  4. Study completion22 May 2029 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2/3
Primary purpose
Supportive care
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
3,110 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05485961
Sponsor's protocol ID
CSL300_2301
Other IDs
2022-500273-14-00
Acronym
POSIBIL6ESKD
Status last verified
Sep 2026
First submitted
29 Jul 2022
Last updated
21 Sep 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: CSL will consider on a case-by-case basis requests to share Individual Patient Data (IPD) with external bona-fide, qualified scientific and medical researchers. For information on the process and requirements for submitting a voluntary data sharing request for IPD, please contact CSL at clinicaltrials@cslbehring.com.

Publications

  • Chertow GM, Chang AM, Felker GM, Heise M, Velkoska E, Fellstrom B, Charytan DM, Clementi R, Gibson CM, Goodman SG, Jardine M, Levin A, Lokhnygina Y, Mears J, Mehran R, Stenvinkel P, Wang AY, Wheeler DC, Zoccali C, Ridker PM, Mahaffey KW, Tricoci P, Wolf M. IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial. Nat Med. 2024 Aug;30(8):2328-2336. doi: 10.1038/s41591-024-03043-1. Epub 2024 May 25.

    PubMed 38796655

Questions about this trial

What is this clinical trial studying?

A Phase 2/3 study testing CSL300 in people with End Stage Kidney Disease, run by CSL Behring at 566 sites in 35 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 21 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 566 sites in United States, China, Japan, Italy, Brazil and 30 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this combined phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Trial Registration Coordinator (+1 610-878-4697, clinicaltrials@cslbehring.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Change from Baseline on the log scale in high-sensitivity C-reactive protein (hs-CRP)(Phase 2b) (time frame: Baseline and up to Week 12). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05485961, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Sep 2026.

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