Neovascular Age-related Macular DegenerationVOYAGERNCT05476926
A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products
An observational study of Neovascular Age-related Macular Degeneration and Diabetic Macular Edema, run by Hoffmann-La Roche at 299 sites in 29 countries.
Trial summary
The VOYAGER study is a primary data collection, non-interventional, prospective, multinational, multicenter study. It is designed to collect real-world, long-term data to explore long-term effectiveness, safety, clinical insights, treatment patterns, and factors driving the treatment decisions among patients being… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- What is being tested?
- Faricimab and Port Delivery System with Ranibizumab
- How many people
- 6,000 participants
- Where
- 299 sitesin 29 countries
- Study dates
- 21 Nov 2022to 30 Nov 2027
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients being treated with specified Roche ophthalmology products approved in retinal indications in real-world, routine clinical practice.
Who may be able to join
- 1. Have provided informed consent, as required per local regulations 2.a) Adult patient, as defined by local regulations and local product label, who is newly initiating treatment (or initiated treatment in the previous visit) with a specified approved Roche ophthalmology product in retinal indication of interest for this study in at least one eye, according to the investigator's discretion in routine clinical practice; OR 2.b) Adult patient, as defined by local regulations and local product label, who is continuing treatment with any specified approved Roche ophthalmology product in retinal indication of interest for this study in at least one eye after initiating that treatment in a Roche interventional trial.
Who cannot join
- 1. Concomitant participation of the patient in an investigational ophthalmology clinical trial that includes receipt of any investigational drug or procedure within the last 28 days prior to enrollment (this restriction does not apply to patients who are rolling over from Roche interventional studies and continuing treatment with any specified approved Roche ophthalmology product in retinal indication of interest for this study)
Trial locations and contacts
299 sites in 29 countries.
299 sites in 29 countries
Japan47 sites
Chukyo Hospital
Aichi, 457-8510
Sugita Eye Hospital
Aichi, 460-0008
Nagoya City University Hospital
Aichi, 467-8602
Akita University Hospital
Akita, 010-8543
Chiba University Hospital
Chiba, 260-8677
Juntendo University Urayasu Hospital
Chiba, 279-0021
Nihon University Hospital
Chiyoda-ku, Tokyo-To, 101-8309
University of Yamanashi Hospital
Chuo-shi, 409-3898
Kyushu University Hospital
Fukuoka, 812-8582
Kurume University Hospital
Fukuoka, 830-0011
Gifu University Hospital
Gifu, 501-1194
Hiroshima University Hospital
Hiroshima, 734-8551
Sapporo City General Hospital
Hokkaido, 060-8604
University of Tsukuba Hospital
Ibaraki, 305-8576
Kozawa eye hospital and diabetes center
Ibaraki, 310-0845
Kagawa University Hospital
Kagawa, 761-0793
Kobe University Hospital
Kobe, Hyōgo, 650-0017
NHO Tokyo Medical Center
Meguro-ku, 152-8902
Mie University Hospital
Mie, 514-8507
Fukushima Medical University Hospital
Miyagi, 960-1295
Aichi Medical University Hospital
Nagakute-shi, Aichi-ken, 480-1195
Shinshu University Hospital
Nagano, 390-8621
Nagasaki University Hospital
Nagasaki, 852-8501
Japanese Red Cross Nagasaki Genbaku Hospital
Nagasaki, 852-8511
Nagoya University Hospital
Nagoya, Aichi-ken, 466-8560
Tazuke-kofukai Medical Research Institute Kitano Hospital
Osaka, 530-8480
Osaka Metropolitan University Hospital
Osaka, 545-8586
Kansai Medical University Hospital
Osaka, 573-1191
Saitama Medical University Hospital
Saitama, 350-0451
Toho University Sakura Medical Center
Sakura-shi, Chiba, 285-8741
Hokkaido University Hospital
Sapporo, Hokkaido, 060-8648
Shiga University Of Medical Science Hospital
Shiga, 520-2192
Jichi Medical University Hospital
Shimotsuke-shi, Tochigi, 329-0498
Tokyo Medical University Hospital
Shinjuku-ku, Tokyo-To, 160-0023
Keio University Hospital
Shinjuku-ku, Tokyo-To, 160-8582
Seirei Hamamatsu General Hospital
Shizuoka, 430-8558
Osaka University Hospital
Suita, 565-0871
Osaka Medical and Pharmaceutical University Hospital
Takatsuki-shi, 569-8686
Tokushima University Hospital
Tokushima, 770-8503
Juntendo University Hospital
Tokyo, 113-8431
Tokyo Women's Medical University Hospital
Tokyo, 162-8666
Kyorin University Hospital
Tokyo, 181-8611
Tokyo Medical University Hachioji Medical Center
Tokyo, 193-0998
Yamagata University Hospital
Yamagata, 990-9585
Yamaguchi University Hospital
Yamaguchi, 755-8505
Yokohama City University Medical Center
Yokohama, Kanagawa, 232-0024
University of Fukui Hospital
Yoshida-gun, 910-1193
France37 sites
Aix Vision
Aix-en-Provence, 13090
CHU Amiens Picardie, Centre de Recherche Clinique
Amiens, Somme, 80080
Hopital Avicenne
Bobigny, Seine Saint Denis, 93000
Groupe Hospitalier Pellegrin
Bordeaux, Gironde, 33800
Centre Rétine Gallien
Bordeaux, 33000
Centre Hospitalier Intercommunal de Créteil
Créteil, 94010
CHU Dijon - Hopital Francois Mitterrand
Dijon, Cte-d'Or, 21079
Clinique du Val d'Ouest- Institut Rhône Alpin
Écully, 69130
Clinique des Yeux Bordeaux
Floirac, 33270
Centre d'Ophtalmologie
Fontainebleau, 77300
Centre Optha Du Dauphine
Grenoble, 38000
Hôpital Saint-Louis - La Rochelle
La Rochelle, 17019
Visiopole Private Practice
Lagord, 17140
Centre Hospitalier de Versailles
Le Chesnay, Yvelines, 78150
Hopital Edouard Herriot - CHU Lyon
Lyon, Rhone, 69003
Centre Hospitalier de la Croix Rousse
Lyon, Rhone, 69004
Centre Ophtalmologique Rabelais
Lyon, 69002
Centre Ophtalmologique Kleber
Lyon, 69006
CH St Joseph
Marseille, Bouches Du Rh(ne, 13285
Centre Monticelli Paradis d Ophtalmologie
Marseille, 13008
Clinique de Montargis
Montargis, 45200
Clinique Honore Cave
Montauban, 82000
Alpes Retine
Montbonnot-Saint-Martin, 38330
Centre Des Arceaux
Montpellier, 34000
CHU de Nantes - Hotel Dieu
Nantes, Loire Atlantique, 44093
Institut Ophtalmologique De l Ouest Jules Verne
Nantes, Paris, 44300
CHU Nice - Hôpital Saint Roch
Nice, 06006
Centre Ophtalmologique de L'Odeon
Paris, 75006
Centre Ophtalmologique d?Imagerie et de Laser
Paris, 75015
CHU Poitiers - Hôpital la Milétrie
Poitiers, 86021
Clinique Mathilde
Rouen, Seine Maritime, 76000
Centre St Exupery
Saint-Cyr-sur-Loire, 37540
CHU de St-Etienne - Hopital Nord
Saint-Étienne-de-Montluc, Pays de la Loire Region, 42055
Institut Sourdille
Saint-Herblain, 44800
Clinique de l'Union
Saint-Jean, 31240
Centre Ophtalmologique Maison-Rouge
Strasbourg, Bas Rhin, 67000
Chu Toulouse
Toulouse, 31059
United Kingdom28 sites
Bedford Hospital
Bedford, Bedfordshire, MK42 9DJ
Mater Infirmorum Hospital
Belfast, BT14 6AB
University Hospitals Birmingham NHS Foundation Trust
Birmingham, B15 2TH
Birmingham Midland Eye Centre
Birmingham, B18 7QH
Bradford Royal Infirmary
Bradford, BD9 6RJ
Bristol Eye Hospital
Bristol, Avon, BS1 2LX
University Hospital of Wales
Cardiff, CF14 4XW
Primary Care Centre
Colchester, Essex, CO4 5JR
Frimley Park Hospital
Frimley, GU16 7UJ
Gloucestershire Retinal Research Group
Gloucester, Gloucestershire, GL1 3NN
James Paget University Hospitals NHS Foundation Trust
Gorleston-on-Sea, Norfolk, NR31 6LA
North West London Hospitals NHS Trust
Harrow, HA1 3UJ
John Radcliffe Hospital
Headington, Oxfordshire, OX3 9DU
Hull Royal Infirmary
Hull, East Riding Of Yorkshire, HU3 2KZ
St James University Hospital
Leeds, LS9 7TF
Royal Liverpool University Hospital
Liverpool, Merseyside, L7 8XP
Kings College Hospital
London, Greater London, SE5 9NU
Moorfields Eye Hospital
London, EC1V 2PD
Royal Free Hospital
London, NW3 2QG
Maidstone Hospital
Maidstone, Kent, ME16 9QQ
Manchester Royal Eye Hospital
Manchester, M13 9WL
James Cook University Hospital
Middlesbrough, TS4 3BW
Royal Victoria Infirmary
Newcastle upon Tyne, NE1 4LP
Royal Hallamshire Hospital
Sheffield, S10 2JF
Southampton General Hospital
Southampton, SO16 6YD
Sunderland Eye Infirmary
Sunderland, SR2 9HP
Torbay Hospital
Torquay, Devon, TQ2 7AA
The Royal Wolverhampton Hospitals NHS Trust
Wolverhampton, WV10 0QP
Germany25 sites
St. Gertrauden Krankenhaus Berlin, Augenheilkunde
Berlin, 10713
Vivantes Klinikum Neukoelln
Berlin, 12351
Klinikum Chemnitz gGmbH
Chemnitz, 09116
Universitaetsklinikum Koeln
Cologne, Koeln
Carl-Thiem-Klinikum Cottbus gGmbH - Augenklinik
Cottbus, Brandenburg, 03048
Martin-Luther-Universitaet Halle-Wittenberg - Staedtisches Klinikum Dessau (SKD)
Dessau, Saxony-Anhalt, 06847
Universitaetsklinikum Carl Gustav Carus TU Dresden
Dresden, Saxony, 01307
Augenklinik des Universitaetsklinikums Erlangen
Erlangen, Bavaria, 91054
Augenzentrum Prof. Koch GmbH
Frankfurt am Main, Hesse, 60549
Universitaetsklinikum Frankfurt Goethe-Universitaet
Frankfurt am Main, Hesse, 60590
Universitaetsmedizin Greifswald
Greifswald, Mecklenburg-Vorpommern, 17475
Universitaetsklinikum Halle (Saale)
Halle, 06120
Medizinische Hochschule Hannover
Hanover, Lower Saxony, 30625
Universitaetsklinikum Heidelberg
Heidelberg, 69120
Universitaetsklinikum Leipzig
Leipzig, Saxony, 04103
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck
Lübeck, Schleswig-Holstein, 23538
Apotheke am Klinikum Ludwigshafen
Ludwigshafen am Rhein, Rhineland-Palatinate, 67063
Universitätsklinikum Mannheim
Mannheim, 68305
Klinikum Ernst von Bergmann gGmbH
Potsdam, Brandenburg, 14467
Praxis Dr. Amin Gamael
Rostock, 18057
Universitaetsaugenklinik Rostock
Rostock, 18057
Knappschaftskrankenhaus Sulzbach
Sulzbach, 66280
Medical Eye Research Xpertx Institut gGmbH
Trier, Bavaria, 86438
Private Practice of Dr. Astrid Sader Moritz
Würzburg, Bavaria, 97080
Augenzentrum Erzgebirge
Zschopau, Saxony, 09405
Italy25 sites
Ente Ecclesiastico Ospedale Generale Regionale F Miulli
Acquaviva Delle Fonti, Piedmont, 70021
Azienda Ospedaliero Universitaria delle Marche
Ancona, The Marches, 60126
Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari
Bari, Apulia, 70124
Humanitas Gavazzeni
Bergamo, Lombardy, 24125
Azienda Ospedaliera Universitaria "Policlinico - Vittorio Emanuele" (Presidio Gaspare Rodolico)
Catania, Sicily, 95123
Azienda Ospedaliero Universitaria Mater Domini
Catanzaro, Calabria, 88100
Ospedale Clinicizzato SS. Annunziata
Chieti, Abruzzo, 66100
IRCCS Ospedale Policlinico San Martino
Genoa, Liguria, 16132
Fondazione IRCCS CA? Granda Ospedale Maggiore Policlinico
Milan, Lombardy, 20122
Ospedale San Giuseppe Fatebenefratelli
Milan, Lombardy, 20123
Ospedale San Raffaele
Milan, Lombardy, 20132
Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo (San Paolo-Polo Universitario)
Milan, Lombardy, 20142
Azienda Socio Sanitaria Territoriale Fatebenefratelli (Presidio Ospedale Sacco)
Milan, Lombardy
Fondazione IRCCS - San Gerardo dei Tintori
Monza, Lombardy, 20900
Ospedale Monaldi - AORN dei Colli
Naples, Campania, 80131
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
Palermo, Sicily, 90127
Fondazione Ptv Policlinico Tor Vergata
Rome, Lazio, 00133
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Lazio, 00168
G. B. Bietti Fondazione - IRCCS
Rome, Lazio, 00184
Azienda Ospedaliera Sant'Andrea-Universitr di Roma La Sapien
Rome, Lazio, 189
Ospedale Di Sassuolo
Sassuolo, Sardinia, 41049
Ospedale Oftalmico
Turin, Piedmont, 10122
Città della Salute e della Scienza di Torino. Presidio Molinette
Turin, Piedmont, 10126
Ospedale Mauriziano Umberto I
Turin, Piedmont, 10128
Azienda Ospedaliera di Udine Ospedale S. Maria della Misericordia
Udine, Friuli Venezia Giulia, 33100
Spain25 sites
Complejo Hospitalario Universitario de Albacete
Albacete, 02006
Hospital de la Santa Creu i Sant Pau
Barcelona, 08025
Hospital Dos de Maig
Barcelona, 08025
Hospital Universitari Vall dHebron (CEMCAT)
Barcelona, 08035
Hospital Clinic de Barcelona
Barcelona, 08036
Hospital de Basurto
Bilbao, Vizcaya, 48013
Complejo Asistencial Universitario de Burgos
Burgos, 09005
Hospital Universitario Puerta del Mar
Cadiz, 11009
Hospital Universitario Reina Sofia
Córdoba, 14004
Complejo Hospitalario Universitario de Ferrol
Ferrol, LA Coruna, 15405
Hospital Universitario Virgen de Las Nieves
Granada, 18012
Fundacio Privada Hospital Asil de Granollers
Granollers, Barcelona, 08402
Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, Barcelona, 08907
Hospital Universitario Insular de Gran Canaria
Las Palmas de Gran Canaria, LAS Palmas, 35016
Complejo Hospitalario San Millán y San Pedro De La Rioja
Logroño, La Rioja, 26006
Hospital Carlos Haya
Málaga, 29010
Hospital Costa del Sol
Marbella, Malaga, 29603
Hospital Universitario Virgen de La Arrixaca
Murcia, 30120
Hospital Universitari Son Espases
Palma de Mallorca, Balearic Islands, 07120
Hospital Universitario Nuestra Señora de la Candelaria
Santa Cruz de Tenerife, Tenerife, 38010
Complejo Hospitalario Universitario de Santiago.
Santiago de Compostela, LA Coruna, 15706
Hospital Universitario Virgen Del Rocio Sevila
Seville, 41013
Hospital Universitario Rio Hortega
Valladolid, 47012
Hospital Xeral-Cies de Vigo
Vigo, Pontevedra, 36204
Hospital Universitario Miguel Servet
Zaragoza, 50009
United States18 sites
Advanced Research
Coral Springs, Florida, 33067
Erie Retinal Surgery
Erie, Pennsylvania, 16507
Cumberland Valley Retina Consultants PC
Hagerstown, Maryland, 21740
University Retina and Macula Associates, PC
Lemont, Illinois, 60439
Retina Associates of Kentucky
Lexington, Kentucky, 40509
Piedmont Eye Center
Lynchburg, Virginia, 24502
Tennessee Retina PC
Nashville, Tennessee, 37203
Wagner Macula and Retina Center
Norfolk, Virginia, 23502-3933
California Eye Specialists Medical group Inc.
Pasadena, California, 91107
Retina Specialty Institute
Pensacola, Florida, 32503
Retinal Research Institute, LLC
Phoenix, Arizona, 85014
Associated Retinal Consultants PC
Royal Oak, Michigan, 48073
Retinal Consultants Medical Group
Sacramento, California, 95825
University of Utah, John Moran Eye Center
Salt Lake City, Utah, 84132
Brown Retina Institute
San Antonio, Texas, 78251-4551
Retina Center of Texas
Southlake, Texas, 76092-1352
Spokane Eye Clinical Research
Spokane, Washington, 99204
Springfield Clinic, Llp
Springfield, Illinois, 62703
Switzerland13 sites
Kantonsspital Aarau AG
Aarau, 5001
Universitätsspital Basel
Basel, 4031
Augenklinik am Lindenhofspital
Bern, 3007
Inselspital-Universitaetsspital Bern
Bern, 3010
Vista Augenklinik Binningen
Binningen, 4102
Hôpitaux Universitaires de Genève
Geneva, 1205
Hôpital ophtalmique Jules-Gonin
Lausanne, 1004
Swiss Visio Montchoisi
Lausanne, 1006
LUKS Spitalbetriebe AG
Lucerne, 6000
Ospedale Regionale di Lugano
Lugano, 6900
Pallas Klinik Olten
Olten, 4600
Kantonsspital St. Gallen
Sankt Gallen, 9007
Stadtspital Triemli
Zurich, 8055
Canada11 sites
Institut De L'Oeil Des Laurentides
Boisbriand, Quebec, J7H 0E8
Toronto Retina Institute
Don Mills, Ontario, M1E 4A7
St Joseph's Centre for Mountain Health Services
Hamilton, Ontario, L9C 0E3
St. Joseph's Health Care - London
London, Ontario, N6A 4V2
Clinique d'ophtalmologie et de Retine de l'est
Montreal, Quebec, H1TY 0E2
Eye Health MD (Opthalmology)
Montreal, Quebec, H4P 2S4
Retina Surgical Associates
New Westminster, British Columbia, V3L 5H1
Retina Institute of Ottawa
Ottawa, Ontario, K2B 7E9
Centre Oculaire de Quebec
Québec, G1V 1T6
Retina MD Clinic
Sainte-Catherine, Quebec, J5C 1V9
Clarity eye Institute
Vaughan, Ontario, L4K 0J4
Australia8 sites
Lions Outback Vision Service in Broome
Broome, Western Australia, 6725
Centre For Eye Research Australia
East Melbourne, Victoria, 3002
Sunshine Coast University Hospital
Geebung, Queensland, 4034
Retina and Macula Specialists
Hurstville, New South Wales, 2220
Cabrini Hospital Malvern
Melbourne, Victoria, 3144
The Lions Eye Institute
Nedlands, Western Australia, 6009
Retina Specialists Victoria
Rowville, Victoria, 3178
Sydney West Retina
Westmead, New South Wales, 2145
Israel7 sites
Rambam Health Care Campus
Haifa, 31096
Wolfson Medical Center
Holon, 58100
Hadassah
Jerusalem, 9112001
Meir Medical Center
Kfar Saba, 4428164
Rabin MC
Petah Tikva, 49100
Tel-Aviv Sourasky Medical Center
Tel Aviv, 6423906
Assuta Hashalom Medical Center
Tel Aviv, 6789140
Thailand7 sites
Ramathibodi Hospital
Bangkok, 10400
Siriraj Hospital
Bangkok, 10700
Maharaj Nakorn Chiang Mai Hospital
Chiang Mai, 50200
Songklanagarind Hospital
Hat Yai, Changwat Songkhla, 90110
Srinagarind Hospital
Muang, Changwat Khon Kaen, 40002
Metta Pracharak Hospital
Nakhon Pathom, RAI Khing, 73210
King Chulalongkorn Memorial Hospital
Pathum Wan, Bangkok, 10330
Argentina5 sites
Instituto Oftalmologico de Buenos Aires S.A.
Buenos Aires, C1056AAN
Centro Oftalmologico Dr. Charles S.A.
Ciudad Autonoma Buenos Aires, C1116ABA
Salud Ocular
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1056
Centro Privado de Ojos Romagosa S.A
Córdoba, 5000
CEO Centro de Especialidades Oftalmologicas Tucuman
San Miguel de Tucumán, T4000IOA
Bulgaria5 sites
Medical Center for Eye Health ? Focus Ltd
Sofia, 1303
Specialized Eye Hospital Pentagram
Sofia, 1319
Specialized Hospital for Active Treatment of Ophthalmologic Diseases ?Zora?, OOD
Sofia, 1784
Eye Clinic St. Petka - Varna
Varna, 9000
SHEDAT - Varna EOOD
Varna, 9002
Croatia5 sites
General Hospital Karlovac
Karlovac, 47000
Clinical Hospital Centre Osijek
Osijek, 31000
Clinical Hospital Centre Rijeka
Rijeka, 51000
Special Hospital for Ophthalmology Svjetlost
Zagreb, 10000
University Hospital Center Zagreb
Zagreb, 10000
Singapore5 sites
National University Hospital
Singapore, 119228
Singapore National Eye Centre
Singapore, 169608
Eye & Retina Surgeons
Singapore, 248649
Tan Tock Seng Hospital
Singapore, 308433
Eagle Eye Centre
Singapore, 329563
Poland4 sites
Centrum Diagnostyki i Mikrochirurgii Oka LENS
Olsztyn, 10-424
Szpital im. Jozefa Strusia
Poznan, 61-285
Szpital Specjalistyczny im Soko?owskiego
Wałbrzych, 58-309
Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy
Warsaw, 04-141
Czechia3 sites
Nemocnice Pardubickeho kraje a.s.
Pardubice, 530 03
Fakultni nemocnice Kralovske Vinohrady
Prague, 100 34
Tomas Bata Regional Hospital
Zlín, 762 75
Denmark3 sites
Ålborg Universitets Hospital
Aalborg, 9100
Rigshospitalet Glostrup
Glostrup Municipality, 2600
Sjllands Universitetshospital
Roskilde, 4000
Taiwan3 sites
Shin Kong Wu Ho-Su Memorial Hospital
Taipei, 111
Far Eastern Memorial Hospital
Taipei, 220
Chang Gung Memorial Hospital - Linkou
Taoyuan, 333
United Arab Emirates3 sites
Burjeel Hopital
Abu Dhabi, 7400
Medcare Eye Center - Dubai
Dubai, 251533
Magrabi Eye Hospital
Dubai Healthcare City, 36267
Chile2 sites
Centro de la Vision
Las Condes, 7600830
Red Salud UC Christus
Santiago, Santiago Metropolitan, 7620002
Hong Kong2 sites
Grantham Hospital
Hong Kong, 00000
Hong Kong Eye Hospital
Kowloon, 000000
South Korea2 sites
Yeungnam University Hospital
Daegu, 42415
CHA Bundang Medical Center, CHA University
Seongnam-si, Gyeonggi-do, 13496
Sweden2 sites
Lund University Hospital
Lund, 22185
St Eriks Eye Hospital
Stockholm, 171 64
Puerto Rico1 site
Emanuelli Research and Development Center
Arecibo, 00612
Slovenia1 site
Univerzitetni Klinicni Center Ljubljana Ocesna Klinika
Ljubljana, 1000
About this study
Official title: Real-World, Long-Term Data Collection to Gain Clinical Insights Into Roche Ophthalmology Products (VOYAGER STUDY)
The VOYAGER study is a primary data collection, non-interventional, prospective, multinational, multicenter study. It is designed to collect real-world, long-term data to explore long-term effectiveness, safety, clinical insights, treatment patterns, and factors driving the treatment decisions among patients being treated with specified Roche ophthalmology products in approved retinal indications (Faricimab for neovascular age-related macular degeneration [nAMD], diabetic macular edema [DME], and retinal vein occlusion; Port Delivery System with Ranibizumab for nAMD) in routine clinical practice. This study will not provide or make recommendations on use of any products including Roche products; treatment decisions will be determined by the treating physician and must be made independently to the decision to participate in this study. Participation in this study will not change or influence a patient's standard of care in any way.
- Conditions
- Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Branch Retinal Vein Occlusion, Central Retinal Vein Occlusion, Hemi-retinal Vein Occlusion
- Being tested
- Faricimab, Port Delivery System with Ranibizumab
- Medical subject headings
- Retinal Vein Occlusion
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
FaricimabDrug
Also called VABYSMO™, RO6867461, RG7716
Faricimab will be administered as per local clinical practice and local labeling.
Port Delivery System with RanibizumabCombination product
Also called SUSVIMO™, RG6321
The port delivery system with ranibizumab will be administered as per local clinical practice and local labeling.
| Study group | Role | What they receive |
|---|---|---|
| Cohort 1: Faricimab for nAMD | Not described Receives: Drug: Faricimab | |
| Cohort 2: Faricimab for DME | Not described Receives: Drug: Faricimab | |
| Cohort 3: Port Delivery System with Ranibizumab for nAMD | Not described Receives: Combination Product: Port Delivery System with Ranibizumab | |
| Cohort 4: Faricimab for BRVO | Not described Receives: Drug: Faricimab | |
| Cohort 5: Faricimab for CRVO/HRVO | Not described Receives: Drug: Faricimab |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Visual Acuity from Baseline at 1 Year, per Approved Retinal Indication and Product
Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.
Measured: Baseline and 1 year
Secondary outcomes (17)
Change in Visual Acuity from Baseline Over Time, per Approved Retinal Indication and Product
Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.
Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Percentage of Eyes on Each Treatment Regimen (Fixed, Treat-and-Extend, As Needed, or Other) Over Time, per Approved Retinal Indication and Product
Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Number of Treatments Over Time, per Approved Retinal Indication and Product
Measured: At 3, 6, and 12 months, and annually thereafter (up to 5 years)
Cumulative Time Spent on Each Treatment per Eye, Overall and per Treatment Regimen (Fixed, Treat-and-Extend, As Needed, or Other), per Approved Retinal Indication and Product
Measured: From Baseline until end of study (up to 5 years)
Percentage of Eyes with Treatment Switch by Reason for Switch Over Time, per Approved Retinal Indication and Product
Measured: At 3, 6, and 12 months, and annually thereafter (up to 5 years)
Percentage of Eyes with Treatment Regimen Switch (Fixed, Treat-and-Extend, As Needed, or Other) by Reason for Switch Over Time, per Approved Retinal Indication and Product
Measured: At 3, 6, and 12 months, and annually thereafter (up to 5 years)
Total Number of Visits per Year, per Approved Retinal Indication and Product
Measured: Annually (up to 5 years)
Number of Visits With or Without Treatment per Year, per Approved Retinal Indication and Product
Measured: Annually (up to 5 years)
Time Interval Between Treatments per Year, per Approved Retinal Indication and Product
Measured: Annually (up to 5 years)
Number of Eyes Treated with Ocular Concomitant and Subsequent Medications by Type and Frequency During the Study, per Approved Retinal Indication and Product
Measured: From Baseline until end of study (up to 5 years)
Change in Visual Acuity from Baseline Over Time, According to Treatment Regimen (Fixed, Treat-and-Extend, As Needed, or Other), per Approved Retinal Indication and Product
Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.
Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Change in Visual Acuity from Baseline Over Time, According to Number of Treatments, per Approved Retinal Indication and Product
Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.
Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Change in Visual Acuity from Baseline Over Time, According to Total Number of Visits, per Approved Retinal Indication and Product
Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.
Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Change in Visual Acuity from Baseline Over Time, According to Treatment Schedule, per Approved Retinal Indication and Product
Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.
Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Change in Central Subfield Thickness (CST) from Baseline Over Time, per Approved Retinal Indication and Product
Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Number of Participants with at Least One Ocular Adverse Event, by Severity and Seriousness, per Approved Retinal Indication and Product
Severity and seriousness will be independently assessed for each adverse event (AE). The terms "severe" and "serious" are not synonymous. Severity refers to the intensity of an AE (e.g., rated as mild, moderate, or severe); the event itself may be of relatively minor medical significance.
Measured: From Baseline until end of study (up to 5 years)
Number of Participants with at Least One Non-Ocular Adverse Event, by Severity and Seriousness, per Approved Retinal Indication and Product
Severity and seriousness will be independently assessed for each adverse event (AE). The terms "severe" and "serious" are not synonymous. Severity refers to the intensity of an AE (e.g., rated as mild, moderate, or severe); the event itself may be of relatively minor medical significance.
Measured: From Baseline until end of study (up to 5 years)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jul 2022
- Study start21 Nov 2022
- Primary completion30 Nov 2026 (estimated)
- Study completion30 Nov 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Neovascular Age-related Macular DegenerationStudies of the same condition, open and under way.
- More trials run by Hoffmann-La RocheThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 6,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hoffmann-La Roche
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Clinical Trials, Study director, Hoffmann-La Roche
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05476926
- Sponsor's protocol ID
- MR41927
- Acronym
- VOYAGER
- Status last verified
- Oct 2026
- First submitted
- 25 Jul 2022
- Last updated
- 2 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: For eligible studies, qualified researchers may request access to individual patient level clinical data. See Roche's commitment to transparency of clinical study information here: https://go.roche.com/data\_sharing
Publications
Bailey C, Pearce I, Dinah C, Dodds M, Vidal-Brime L, Wilson A, Ellis J, Hall J, Pohler R, Shi B, Toshev D, Guymer R. Automated data collection from an electronic medical record for a prospective real-world study in patients with retinal disease (VOYAGER). Clin Trials. 2025 Dec;22(6):637-648. doi: 10.1177/17407745251358235. Epub 2025 Aug 31.
PubMed 40886069