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Hereditary AngioedemaPhase 3APeX-PNCT05453968

Berotralstat Treatment in Children With Hereditary Angioedema

A Phase 3 study testing Berotralstat in people with Hereditary Angioedema and Pediatric, run by BioCryst Pharmaceuticals at 15 sites in 10 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
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Trial summary

The purpose of this study is to evaluate the pharmacokinetics (PK), safety and effectiveness of berotralstat to determine the appropriate weight-based dose for pediatric participants 2 to < 12 years of age for prophylactic treatment to prevent attacks of hereditary angioedema (HAE). Read more about this study

Who is it for?
Ages 2 to 11 years
Conditions the study is for
Hereditary Angioedema, Pediatric
What is being tested?
Berotralstat
Type of treatment
Pill or oral medicine
Could I receive a placebo?
No, everyone receives an active treatment
How many people
29 participants
Where
15 sitesin 10 countries
Study dates
25 Oct 2022to Feb 2027
Phase
Phase 3
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 2 to 11 years
  • All sexes
  • No healthy volunteers
  • Child

Who may be able to join

  • Male and non-pregnant, non-lactating females 2 to < 12 years of age
  • Body weight ≥ 12 kg
  • Clinical diagnosis of HAE
  • In the opinion of the investigator, the participant would benefit from long term oral HAE prophylaxis
  • For subjects who are not currently receiving prophylaxis for HAE, documented history of >= 2 HAE attacks in the 6 months prior to the enrollment visit.

Who cannot join

  • Concurrent diagnosis of any other type of recurrent angioedema
  • Known family history of sudden cardiac death at a young age (< 40 years of age)
  • Creatinine clearance using the modified Schwartz formula of ≤ 30 mL/min/1.73 m^2
  • Aspartate aminotransferase or alanine aminotransferase value ≥ 3 × the upper limit of the age-appropriate normal reference range value
  • Clinically significant abnormal electrocardiogram (ECG) including but not limited to, a corrected QT interval using Fridericia's correction > 450 msec, or ventricular and/or atrial premature contractions that are more frequent than occasional, and/or as couplets or higher in grouping
  • Current participation in any other investigational drug study or received another investigational drug within 30 days of enrollment

Trial locations and contacts

15 sites in 10 countries.

15 sites in 10 countries

France3 sites
  • Investigative Site #3

    Grenoble

  • Investigative Site #2

    Marseille

  • Investigative Site #1

    Paris

Other trials in France

Germany2 sites
  • Investigative Site #1

    Berlin

  • Investigative Site #2

    Frankfurt

Other trials in Germany

Israel2 sites
  • Investigative Site #2

    Haifa

  • Investigative Site #1

    Tel Aviv

Other trials in Israel

Spain2 sites
  • Investigative Site #1

    Madrid

  • Investigative Site #2

    Málaga

Other trials in Spain

Austria1 site
  • Investigative Site #1

    Vienna, Ontario

Other trials in Austria

Canada1 site
  • Investigative Site #1

    Ottawa, Ontario

Other trials in Canada

Italy1 site
  • Investigative Site #1

    Padova

Other trials in Italy

Poland1 site
  • Investigative Site #1

    Krakow

Other trials in Poland

Romania1 site
  • Investigative Site #1

    Sângeorgiu de Mureş

Other trials in Romania

United Kingdom1 site
  • Investigative Site #1

    Bristol

Other trials in United Kingdom

About this study

Official title: A Phase 3 Study to Evaluate the Safety and Pharmacokinetics of Berotralstat Prophylaxis in Children With Hereditary Angioedema Who Are 2 to < 12 Years of Age

The purpose of this study is to evaluate the pharmacokinetics (PK), safety and effectiveness of berotralstat to determine the appropriate weight-based dose for pediatric participants 2 to < 12 years of age for prophylactic treatment to prevent attacks of hereditary angioedema (HAE).

Read the detailed description

This is a single-arm, 3-part, open-label study designed to evaluate the PK, safety, and effectiveness of berotralstat weight-based treatment for the prevention of HAE attacks in pediatric participants 2 to < 12 years of age. Participation in this study is expected to be a minimum of 12 weeks in the standard of care (SOC) period, and in the berotralstat period, it is expected to be 12 weeks in Part 1, 36 weeks in Part 2, and 96 weeks in Part 3 of the study.

Participants were enrolled into 4 cohorts; participant weight at baseline was used to determine assignment to each cohort with the higher weight cohorts (Cohorts 1 and 2) enrolling first and in parallel. Safety assessments and PK modelling from all available PK data were then used to confirm the dose and weight bands for sequentially enrolling Cohorts 3 and 4. The safety and effectiveness of berotralstat in this population was summarized using descriptive statistical methods.

Being tested
Berotralstat
Keywords
Berotralstat, BCX7353, Orladeyo, once a day, Hereditary angioedema (HAE), Pediatric, kallikrein inhibitor, Oral
Medical subject headings
Angioedemas, Hereditary

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • BerotralstatDrug

    Also called BCX7353, Orladeyo®

    Administered orally once daily

Study groups in NCT05453968
Study groupRoleWhat they receive
Cohort 1: ≥ 40 kg body weight (Berotralstat 150 mg)ExperimentalParticipants received 150 milligram (mg) berotralstat capsule orally once daily for up to 144 weeks. Dose modifications were permitted due to weight changes, PK results, or safety.
Receives: Drug: Berotralstat
Cohort 2: 32 to < 40 kg body weight (Berotralstat 108 mg)ExperimentalParticipants received 108 mg berotralstat granules orally once daily for up to 144 weeks. Dose modifications were permitted due to weight changes, PK results, or safety.
Receives: Drug: Berotralstat
Cohort 3: 24 to < 32 kg body weight (Berotralstat 96 mg)ExperimentalParticipants received 96 mg berotralstat granules orally once daily for up to 144 weeks. Dose modifications were permitted due to weight changes, PK results, or safety.
Receives: Drug: Berotralstat
Cohort 4: 12 to <24 kg body weight (Berotralstat 78 mg)ExperimentalParticipants received 78 mg berotralstat granules orally once daily for up to 144 weeks. Dose modifications were permitted due to weight changes, PK results, or safety.
Receives: Drug: Berotralstat

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Area Under the Plasma Concentration-Time Curve From Time 0 to the Last Measurable Concentration (AUC0-last) of Berotralstat

    AUC0-last is the area under the plasma concentration-time curve from time 0 to the time of the last measurable concentration.

    Measured: Week 2

  2. Area Under the Plasma Concentration-Time Curve From Time 0 to 6 Hours Post-dose (AUC0-6) of Berotralstat

    AUC0-6 is the area under the plasma concentration-time curve from time 0 to 6 hours.

    Measured: Predose and up to 6 hours post dose at Week 2

  3. Concentration at the End of the Dosing Interval (Ctrough) of Berotralstat

    Ctrough is the concentration at the end of a dosing interval of berotralstat.

    Measured: Predose at Week 2

  4. Maximum Observed Plasma Concentration (Cmax) of Berotralstat

    Cmax is the maximum observed plasma concentration of berotralstat.

    Measured: Predose and up to 6 hours post dose at Week 2

  5. Time of Last Measurable Plasma Concentration (Tlast) of Berotralstat

    Tlast is the time of the last measurable concentration (Clast) of berotralstat collected over the sampling interval.

    Measured: Predose and up to 6 hours post dose at Week 2

  6. Time to Maximum Plasma Concentration (Tmax) of Berotralstat

    Tmax is the time taken to reach the maximum observed plasma concentration of berotralstat.

    Measured: Predose and up to 6 hours post dose at Week 2

Secondary outcomes (12)
  1. Number of Participants With Treatment Emergent Adverse Events (TEAEs)

    An adverse event (AE) is any untoward medical occurrence in a clinical study participant. No causal relationship with study drug or with the clinical study itself is implied. An AE could be an unfavorable and unintended sign, symptom (including an abnormal laboratory finding), syndrome, or illness that developed or worsened during the clinical study. A serious adverse event (SAE) is any untoward medical occurrence resulting in death, is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, results in a congenital anomaly/birth defect, or other medically important event. TEAEs are AEs that occurred on/after first dose of berotralstat through 30 days post discontinuation of study treatment.

    Measured: From first dose of study treatment up to approximately 73 weeks

  2. Number of Adjusted Hereditary Angioedema (HAE) Attacks

    Adjusted attacks included at least 1 symptom of swelling, had a response of "no" to the diary question: "In retrospect, could there be an alternative explanation for your symptoms other than an HAE attack (that is, allergic reaction, viral cold etc.)?",were considered unique (attack began > 24 hours from the end of the prior attack), and if the entire adjusted attack was untreated, it had a duration of > 24 hours. Any attack that began within 24 hours from the end of a prior attack was combined with the prior attack.

    Measured: Week 1 through Week 12 and Week 1 through Week 48

  3. Rate of Adjusted HAE Attacks

    Adjusted attacks included at least 1 symptom of swelling, had a response of "no" to the diary question: "In retrospect, could there be an alternative explanation for your symptoms other than an HAE attack (that is, allergic reaction, viral cold etc.)?",were considered unique (attack began > 24 hours from the end of the prior attack), and if the entire adjusted attack was untreated, it had a duration of > 24 hours. Any attack that began within 24 hours from the end of a prior attack was combined with the prior attack.

    The adjusted attack rate was calculated as the number of adjusted attacks observed during a given period and standardized to number of attacks per month, where 1 month is defined as a 28-day (4 week) period.

    Measured: Week 1 through Week 12 and Week 1 through Week 48

  4. Duration of Adjusted HAE Attack Symptoms

    Adjusted attacks included at least 1 symptom of swelling, had a response of "no" to the diary question: "In retrospect, could there be an alternative explanation for your symptoms other than an HAE attack (that is, allergic reaction, viral cold etc.)?",were considered unique (attack began > 24 hours from the end of the prior attack), and if the entire adjusted attack was untreated, it had a duration of > 24 hours. Any attack that began within 24 hours from the end of a prior attack was combined with the prior attack. The duration of each participant-reported attack was calculated in hours, based on the start, and stop date and time of the adjusted attack (time the attack finished).

    Measured: Week 1 through Week 12 and Week 1 through Week 48

  5. Incidence of Adjusted HAE Attack Based on Anatomical Location

    Adjusted attacks were assessed based on anatomical location. Adjusted attacks included at least 1 symptom of swelling, had a response of "no" to the diary question: "In retrospect, could there be an alternative explanation for your symptoms other than an HAE attack (that is, allergic reaction, viral cold etc.)?", were considered unique (attack began > 24 hours from the end of the prior attack), and if the entire adjusted attack was untreated, it had a duration of > 24 hours. Any attack that began within 24 hours from the end of a prior attack was combined with the prior attack.

    Anatomical locations were categorized as abdominal-only, non-abdominal peripheral, mixed, and laryngeal attacks.

    Measured: Week 1 through Week 12 and Week 1 through Week 48

  6. Number of Adjusted Attacks Requiring On-Demand Treatment

    Adjusted attacks included at least 1 symptom of swelling, had a response of "no" to the diary question: "In retrospect, could there be an alternative explanation for your symptoms other than an HAE attack (that is, allergic reaction, viral cold etc.)?", were considered unique (attack began > 24 hours from the end of the prior attack), and if the entire adjusted attack was untreated, it had a duration of > 24 hours. Any attack that began within 24 hours from the end of a prior attack was combined with the prior attack.

    Number of adjusted attacks treated with targeted HAE medications was assessed.

    Measured: Week 1 through Week 12 and Week 1 through Week 48

  7. Proportion of Adjusted Attacks Requiring On-Demand Treatment

    Adjusted attacks included at least 1 symptom of swelling, had a response of "no" to the diary question: "In retrospect, could there be an alternative explanation for your symptoms other than an HAE attack (that is, allergic reaction, viral cold etc.)?", were considered unique (attack began > 24 hours from the end of the prior attack), and if the entire adjusted attack was untreated, it had a duration of > 24 hours. Any attack that began within 24 hours from the end of a prior attack was combined with the prior attack.

    Proportion of adjusted attacks treated with targeted HAE medications was assessed.

    Measured: Week 1 through Week 12 and Week 1 through Week 48

  8. Number of Days With Angioedema Symptoms

    Adjusted attacks included at least 1 symptom of swelling, had a response of "no" to the diary question: "In retrospect, could there be an alternative explanation for your symptoms other than an HAE attack (that is, allergic reaction, viral cold etc)?",were considered unique (attack began > 24 hours from the end of the prior attack),and if the entire adjusted attack was untreated, it had a duration of > 24 hours. Any attack that began within 24 hours from the end of a prior attack was combined with the prior attack.

    The number of days with angioedema symptoms is the number of the days during the reporting period for which at least 1 symptom is reported during an adjusted HAE attack based on the start date and resolution date of an attack.

    Measured: Week 1 through Week 12 and Week 1 through Week 48

  9. Proportion of Days With Angioedema Symptoms

    Adjusted attacks included at least 1 symptom of swelling, had a response of "no" to the diary question: "In retrospect, could there be an alternative explanation for your symptoms other than an HAE attack (that is, allergic reaction, viral cold etc)?",were considered unique (attack began > 24 hours from the end of the prior attack),and if the entire adjusted attack was untreated, it had a duration of > 24 hours. Any attack that began within 24 hours from the end of a prior attack was combined with the prior attack.

    The proportion of days with angioedema symptoms was based on the number of days with reported symptoms and the number of days the participant was on treatment, where the number of days with angioedema symptoms is the number of the days during the reporting period for which at least 1 symptom is reported during an adjusted HAE attack based on the start date and resolution date of an attack.

    Measured: Week 1 through Week 12 and Week 1 through Week 48

  10. Assessment of Adjusted HAE Attack Severity

    Adjusted attacks included at least 1 symptom of swelling, had a response of "no" to the diary question: "In retrospect, could there be an alternative explanation for your symptoms other than an HAE attack (that is, allergic reaction, viral cold etc.)?", were considered unique (attack began > 24 hours from the end of the prior attack), and if the entire adjusted attack was untreated, it had a duration of > 24 hours. Any attack that began within 24 hours from the end of a prior attack was combined with the prior attack. The severity was assessed by the parent/caregiver as negligible, mild, moderate or severe.

    Measured: Week 1 through Week 12 and Week 1 through Week 48

  11. Number of Participants Who Discontinued Treatment Due to Perceived Lack of Efficacy

    The total number of participants who discontinued the treatment due to perceived lack of efficacy of berotralstat were reported.

    Measured: Week 1 through Week 12 and Week 1 through Week 48

  12. Number of Hospitalizations and Clinic Visits Due to HAE

    Adjusted attacks included at least 1 symptom of swelling, had a response of "no" to the diary question: "In retrospect, could there be an alternative explanation for your symptoms other than an HAE attack (that is, allergic reaction, viral cold etc.)?", were considered unique (attack began > 24 hours from the end of the prior attack), and if the entire adjusted attack was untreated, it had a duration of > 24 hours. Any attack that began within 24 hours from the end of a prior attack was combined with the prior attack.

    Number of adjusted attacks that required hospitalization or clinic visits are reported.

    Measured: Week 1 through Week 12 and Week 1 through Week 48

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted12 Jul 2022
  2. Study start25 Oct 2022
  3. Primary completion11 Sep 2024
  4. Study completionFeb 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Prevention
Allocation
Non-randomised
Intervention model
Single group
Model description
This is a sequential, 3-part, open-label study. Participants were assigned a cohort based on weight at baseline.
Masking
None (open label)
Enrolment
29 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05453968
Sponsor's protocol ID
BCX7353-304
Other IDs
2021-005932-50
Acronym
APeX-P
Status last verified
Feb 2026
First submitted
30 Jun 2022
Last updated
25 Feb 2026
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
No

Publications

  • Bernatoniene J, Bourgoin-Heck M, Cancian M, Yang W, Hagin D, Pagnier A, Stobiecki M, Kinaciyan T, Phillips-Angles E, Gayet S, Bara NA, Hunter J, Mateescu E, DeSpirito M, Johnston D, Long D, Iocca H, Petroni D, Aygoren-Pursun E. Oral berotralstat for hereditary angioedema prophylaxis in patients aged 2 to <12 years: APeX-P interim results. Ann Allergy Asthma Immunol. 2025 Dec;135(6):681-688.e3. doi: 10.1016/j.anai.2025.07.012. Epub 2025 Jul 25.

    PubMed 40716738

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Berotralstat in people with Hereditary Angioedema and Pediatric, run by BioCryst Pharmaceuticals at 15 sites in 10 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 25 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 15 sites in France, Germany, Israel, Spain, Austria and 5 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

Yes. Results are posted in the registry (first posted 25 Feb 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Area Under the Plasma Concentration-Time Curve From Time 0 to the Last Measurable Concentration (AUC0-last) of Berotralstat (time frame: Week 2). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05453968, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Feb 2026.

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