Idiopathic Pulmonary FibrosisPhase 1FIPOXYNCT05331729
Evaluation of the Value of 18F-Fluoromisonidazole (18F-FMISO) Positron Emission Tomography Hypoxia Imaging in Idiopathic Pulmonary Fibrosis
A Phase 1 study testing FMISO-PET Protocol in people with Idiopathic Pulmonary Fibrosis, run by Centre Hospitalier Universitaire Dijon at 1 site in France.
Trial summary
Idiopathic pulmonary fibrosis (IPF) is a rare, chronic, lethal disease of unknown etiology and with a variable course. There is currently no test in routine care that can assess both the anatomical and functional damage of the disease at an early stage. Read more about this study
- Who is it for?
- Ages 50 years and olderHealthy volunteers can take part
- Conditions the study is for
- Idiopathic Pulmonary Fibrosis
- What is being tested?
- FMISO-PET Protocol
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteFrance
- Study dates
- 20 Mar 2023to 20 Feb 2025
- Phase
- Phase 1
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- For all patients (IPF and healthy volunteers) :
- Person who has given written consent
- Age ≥ 50 years
- Absence of disease, comorbidity, or treatment that may interfere with the evaluation of the study objective, as decided by the investigator
- For patients with IPF only:
- Diagnosis of IPF according to the criteria of the current international recommendations (ATS/ERS/JRS/ALAT of 2011) and validated in a multi-disciplinary meeting in a Competence or Reference Center
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- Patients who have had a high-resolution thoracic CT scan less than 1 month previously as part of the management of their disease
- Patients who have had a PFT less than 1 month previously as part of the management of their disease
- For healthy volunteers only:
- Absence of functional respiratory signs - absence of dyspnea on exertion and at rest and absence of chronic cough.
- Normal clinical examination with no crackles on pulmonary auscultation
- No personal history of chronic hypoxemic respiratory disease
Who cannot join
- Person who is not covered by national health insurance
- Cancer or history of cancer in the past 5 years (except basal cell skin cancer)
- Chronic lung disease other than IPF or a history incompatible with the diagnosis of idiopathic pulmonary fibrosis (thoracic radiotherapy, pneumotoxic chemotherapy, etc.)
- Exacerbation of IPF during treatment
- Active smoking
- Patient requiring long-term oxygen therapy (excluding ambulatory oxygen therapy alone)
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- Contraindication to PET or CT scan or presence of a condition disturbing the interpretation :
- known allergy to 18F-FMISO
- pregnancy or breastfeeding
- claustrophobia
- uncontrolled type I/II diabetes (HbA1c >7%)
- surgical intervention in the previous month
- Radiotherapy session in the previous 3 months
- concomitant granulomatous condition (sarcoidosis type) or pulmonary inflammation
- Moderate or severe renal insufficiency (GFR < 70 ml/min/1.73 m²)
- Person under legal protection (curatorship, guardianship)
- Adult unable to express consent
- SECONDARY EXCLUSION CRITERIA only for healthy volunteers
- Abnormal 6 min walk test at screening
- Abnormal PFT at screening with FVC ≤ 80% of predicted value and DLCO ≤ 75% of predicted value
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Evaluation of the Value of 18F-Fluoromisonidazole (18F-FMISO) Positron Emission Tomography Hypoxia Imaging in Idiopathic Pulmonary Fibrosis - a Non-randomized Proof-of-concept Study Comparing Patients with Idiopathic Pulmonary Fibrosis and Healthy Subjects
Idiopathic pulmonary fibrosis (IPF) is a rare, chronic, lethal disease of unknown etiology and with a variable course. There is currently no test in routine care that can assess both the anatomical and functional damage of the disease at an early stage. This is the first human study in IPF to evaluate the value of a non-invasive tracer, 18F-fluoromisonidazole (18F-FMISO), targeting hypoxia in IPF patients.
This is a Phase I, proof-of-concept, single-center, open-label, parallel group study.
It will include 2 groups:
- 1 group of 10 IPF patients
- 1 group of 10 healthy volunteers matched to IPF patients for age and gender
- Conditions
- Idiopathic Pulmonary Fibrosis
- Being tested
- FMISO-PET Protocol
- Medical subject headings
- Idiopathic Pulmonary Fibrosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
FMISO-PET ProtocolRadiation
- injection of 18F-FMISO
- Monitoring for 2 h
- PET scan (30 min) 2h post injection
- Monitoring for 2h
- PET (30min) 4h post injection
- Discharge of the subject with appropriate recommendations after a PET/CT
| Study group | Role | What they receive |
|---|---|---|
| Patients with idiopathic pulmonary fibrosis | Experimental | Not described Receives: Radiation: FMISO-PET Protocol |
| Healthy volunteers | Active comparator | Not described Receives: Radiation: FMISO-PET Protocol |
What is being measured
The primary outcome is the main question the study is designed to answer.
Lung SUVmean of 18F-FMISO measured in PET
Comparison in IPF patients and healthy volunteers
Measured: At baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Apr 2022
- Study start20 Mar 2023
- Primary completion20 Feb 2025
- Study completion20 Feb 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Idiopathic Pulmonary FibrosisStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire DijonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 1
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire Dijon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05331729
- Sponsor's protocol ID
- BELTRAMO_APJ_2019
- Acronym
- FIPOXY
- Status last verified
- Feb 2025
- First submitted
- 4 Apr 2022
- Last updated
- 4 Mar 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Value of 18F-Fluoromisonidazole (18F-FMISO) Positron Emission Tomography Hypoxia Imaging in Idiopathic Pulmonary Fibrosis - a Non-randomized Proof-of-concept Study Comparing Patients with Idiopathic Pulmonary Fibrosis and Healthy Subjects
- ClinicalTrials.gov ID
- NCT05331729
- Acronym / sponsor ID
- FIPOXY / BELTRAMO_APJ_2019
- Conditions
- Idiopathic Pulmonary Fibrosis
- Phase
- Phase 1
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire DijonUniversity, hospital or other
- Study start
- 20 Mar 2023 (actual)
- Primary completion
- 20 Feb 2025 (actual)
- Study completion
- 20 Feb 2025 (actual)
- First posted
- 18 Apr 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Idiopathic pulmonary fibrosis (IPF) is a rare, chronic, lethal disease of unknown etiology and with a variable course. There is currently no test in routine care that can assess both the anatomical and functional damage of the disease at an early stage. This is the first human study in IPF to evaluate the value of a non-invasive tracer, 18F-fluoromisonidazole (18F-FMISO), targeting hypoxia in IPF patients.
This is a Phase I, proof-of-concept, single-center, open-label, parallel group study.
It will include 2 groups:
- 1 group of 10 IPF patients
- 1 group of 10 healthy volunteers matched to IPF patients for age and gender
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Patients with idiopathic pulmonary fibrosis | Experimental | Radiation: FMISO-PET Protocol |
| Healthy volunteers | Active comparator | Radiation: FMISO-PET Protocol |
Who may qualify
- Ages
- 50 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (12 listed)
- Person who has given written consent
- Age ≥ 50 years
- Absence of disease, comorbidity, or treatment that may interfere with the evaluation of the study objective, as decided by the investigator
- Diagnosis of IPF according to the criteria of the current international recommendations (ATS/ERS/JRS/ALAT of 2011) and validated in a multi-disciplinary meeting in a Competence or Reference Center
- Patients who have had a high-resolution thoracic CT scan less than 1 month previously as part of the management of their disease
Key exclusion criteria (20 listed)
- Person who is not covered by national health insurance
- Cancer or history of cancer in the past 5 years (except basal cell skin cancer)
- Chronic lung disease other than IPF or a history incompatible with the diagnosis of idiopathic pulmonary fibrosis (thoracic radiotherapy, pneumotoxic chemotherapy, etc.)
- Exacerbation of IPF during treatment
- Active smoking
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| FMISO-PET Protocol* injection of 18F-FMISO * Monitoring for 2 h * PET scan (30 min) 2h post injection * Monitoring for 2h * PET (30min) 4h post injection * Discharge of the subject with appropriate recommendations after a PET/CT | Radiation | Healthy volunteers, Patients with idiopathic pulmonary fibrosis |
Primary outcome
Lung SUVmean of 18F-FMISO measured in PET
Time frame: At baseline
Comparison in IPF patients and healthy volunteers
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Mar 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 1 study testing FMISO-PET Protocol in people with Idiopathic Pulmonary Fibrosis, run by Centre Hospitalier Universitaire Dijon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 12 inclusion and 20 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Lung SUVmean of 18F-FMISO measured in PET (time frame: At baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Mar 2025.