Metabolic DiseaseNCT05321914
Resistance Exercise, Metabolism and Time of Day
A study testing Exercise training in people with Metabolic Disease, run by University of Glasgow at 1 site in United Kingdom.
Trial summary
The aim of the current study is to determine the effect of time of day on the muscle and metabolic responses to resistance exercises in obese or overweight adults. To achieve this aim we have the following objectives: 1. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Metabolic Disease
- What is being tested?
- Exercise training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 1 May 2022to 1 Feb 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- pass the physical activity readiness questionnaire
- body mass index (BMI) >27kg/m² and limited to 40 kg/m².
Who cannot join
- Prior surgery for weight loss
- Prior history of heart, lung, cancer, endocrine or liver disease
- Participating in more than 1 hour structured exercise training per week
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Impact of the Time of Day on Metabolic Responses to Resistance Exercise in Adults Who Are Obese or Overweight: a Randomised Controlled Trial
The aim of the current study is to determine the effect of time of day on the muscle and metabolic responses to resistance exercises in obese or overweight adults. To achieve this aim we have the following objectives:
- Compare the effects of resistance exercise training performed in the morning vs the evening on insulin sensitivity
- Compare the effects of resistance exercise training performed in the morning vs the evening on gains in muscle mass and strength
- Compare the acute glucose responses to resistance exercise performed in the morning vs the evening
- Conditions
- Metabolic Disease
- Being tested
- Exercise training
- Keywords
- exercise, muscle, metabolism, circadian
- Medical subject headings
- Metabolic Diseases, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exercise trainingBehavioural
Exercise will consist of 1 set x 9 exercises x 3 sessions per week x 6 weeks. The load to be used during training will be calculated as 80% of one-repetition maximum (1RM) with each set performed to failure. 1RM will be re-tested on week 3, and the load adjusted accordingly, and upon completion of the study. During the training period, all sessions of training will be supervised by the researcher. The following exercises will be performed: Bench press, biceps curl, lat pull down, overhead press, lateral raise, leg extension, leg curl and calf raise.
| Study group | Role | What they receive |
|---|---|---|
| Control | No intervention | Habitual physical activity |
| Morning exercise | Experimental | Exercise training in the morning (6:00-10:00am) Receives: Behavioral: Exercise training |
| Evening exercise | Experimental | Exercise training in the evening (4:00-8:00pm) Receives: Behavioral: Exercise training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in insulin sensitivity
Insulin sensitivity calculated via the Matsuda Index during an oral glucose tolerance test
Measured: Change from baseline to 6 weeks
Secondary outcomes (8)
Change in vastus lateralis muscle thickness
Muscle thickness of the vastus lateralis muscle measured via ultrasound
Measured: Change from baseline to 6 weeks
Change in whole body lean mass
whole body lean mass measured via bio-electrical impedance
Measured: Change from baseline to 6 weeks
Change in whole body fat mass
whole body fat mass measured via bio-electrical impedance
Measured: Change from baseline to 6 weeks
Change in one-repetition maximum muscle strength
Sum of one-repetition maximum of Bench press, biceps curl, lat pull down, overhead press, lateral raise, leg extension, leg curl and calf raise exercise
Measured: Change from baseline to 6 weeks
Change in knee extensor maximal isometric torque
Knee extensor maximal isometric torque measured during a maximal voluntary contraction
Measured: Change from baseline to 6 weeks
Change in grip strength
Grip strength measured with a hand held dynamometer
Measured: Change from baseline to 6 weeks
Change in mean glucose levels
Mean glucose levels measured via continuous glucose monitors
Measured: Change from baseline to 6 weeks
Change in glucose variability
Glucose variability measured via continuous glucose monitors
Measured: Change from baseline to 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Apr 2022
- Study start1 May 2022
- Primary completion1 Feb 2024
- Study completion1 Feb 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Metabolic DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Glasgow
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Stuart Gray, University of Glasgow
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05321914
- Sponsor's protocol ID
- 200210068
- Status last verified
- Mar 2025
- First submitted
- 1 Apr 2022
- Last updated
- 30 Mar 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Dighriri A, Lithgow H, Gabriel B, Altuwrqi M, Dunning E, Johnston L, Boyle JG, Logan G, Gray SR. The impact of the time of day on muscle and metabolic responses to resistance exercise in healthy adults: A randomised controlled trial. Exp Physiol. 2026 Mar;111(3):1109-1119. doi: 10.1113/EP093020. Epub 2025 Nov 13.
PubMed 41231202
Study at a glance
From the registry record, last updated by the sponsor on 30 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Impact of the Time of Day on Metabolic Responses to Resistance Exercise in Adults Who Are Obese or Overweight: a Randomised Controlled Trial
- ClinicalTrials.gov ID
- NCT05321914
- Acronym / sponsor ID
- 200210068
- Conditions
- Metabolic Disease
- Keywords
- exercise, muscle, metabolism, circadian
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- University of GlasgowUniversity, hospital or other
- Study start
- 1 May 2022 (actual)
- Primary completion
- 1 Feb 2024 (actual)
- Study completion
- 1 Feb 2024 (actual)
- First posted
- 11 Apr 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of the current study is to determine the effect of time of day on the muscle and metabolic responses to resistance exercises in obese or overweight adults. To achieve this aim we have the following objectives:
- Compare the effects of resistance exercise training performed in the morning vs the evening on insulin sensitivity
- Compare the effects of resistance exercise training performed in the morning vs the evening on gains in muscle mass and strength
- Compare the acute glucose responses to resistance exercise performed in the morning vs the evening
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Control | No intervention | –Habitual physical activity |
| Morning exercise | Experimental | Behavioral: Exercise trainingExercise training in the morning (6:00-10:00am) |
| Evening exercise | Experimental | Behavioral: Exercise trainingExercise training in the evening (4:00-8:00pm) |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- pass the physical activity readiness questionnaire
- body mass index (BMI) >27kg/m² and limited to 40 kg/m².
Key exclusion criteria (3 listed)
- Prior surgery for weight loss
- Prior history of heart, lung, cancer, endocrine or liver disease
- Participating in more than 1 hour structured exercise training per week
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Exercise trainingExercise will consist of 1 set x 9 exercises x 3 sessions per week x 6 weeks. The load to be used during training will be calculated as 80% of one-repetition maximum (1RM) with each set performed to failure. 1RM will be re-tested on week 3, and the load adjusted accordingly, and upon completion of the study. During the training period, all sessions of training will be supervised by the researcher. The following exercises will be performed: Bench press, biceps curl, lat pull down, overhead press, lateral raise, leg extension, leg curl and calf raise. | Behavioural | Evening exercise, Morning exercise |
Primary outcome
Change in insulin sensitivity
Time frame: Change from baseline to 6 weeks
Insulin sensitivity calculated via the Matsuda Index during an oral glucose tolerance test
8 secondary outcomes
Change in vastus lateralis muscle thickness
Time frame: Change from baseline to 6 weeks
Change in whole body lean mass
Time frame: Change from baseline to 6 weeks
Change in whole body fat mass
Time frame: Change from baseline to 6 weeks
Change in one-repetition maximum muscle strength
Time frame: Change from baseline to 6 weeks
Change in knee extensor maximal isometric torque
Time frame: Change from baseline to 6 weeks
Change in grip strength
Time frame: Change from baseline to 6 weeks
Change in mean glucose levels
Time frame: Change from baseline to 6 weeks
Change in glucose variability
Time frame: Change from baseline to 6 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Mar 2025.
- Derived from this study: PubMed 41231202Dighriri A, Lithgow H, Gabriel B, Altuwrqi M, Dunning E, Johnston L, Boyle JG, Logan G, Gray SR. The impact of the time of day on muscle and metabolic responses to resistance exercise in healthy adults: A randomised controlled trial. Exp Physiol. 2026 Mar;111(3):1109-1119. doi: 10.1113/EP093020. Epub 2025 Nov 13.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise training in people with Metabolic Disease, run by University of Glasgow at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in insulin sensitivity (time frame: Change from baseline to 6 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05321914, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Mar 2025.