Other Gastrointestinal DisordersNCT05217589
The Influence of Different Mood States and Emotions on the Physiologic, Metabolic, and Perceptual Responses to Feeding Before Exercise
A study testing Funny/Amusing Video Clips, Horror/Scary Video Clips and Thrilling/Suspenseful Video Clips in people with Other Gastrointestinal Disorders and Cramp, Abdominal, run by Old Dominion University at 1 site in United States.
Trial summary
Many athletes anecdotally report modifying their nutritional intake before competition in order to avoid gut problems, but no studies have evaluated whether emotional state impacts tolerance to pre-exercise feeding. Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Other Gastrointestinal Disorders, Cramp, Abdominal
- What is being tested?
- Funny/Amusing Video Clips, Horror/Scary Video Clips and Thrilling/Suspenseful Video Clips
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 28 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Apr 2022to 2 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Aged 18 to 55 years
- Able to run for 30 min at a moderate-to-vigorous intensity without stopping
- No diagnosis or signs/symptoms of cardiovascular disease (CVD) or metabolic disorders
- Currently physically active (at least 3 days/week of exercise at a moderate or higher intensity)
- No visual or hearing impairments interfering with ability to see and hear video clips
- No allergies to ingredients in Boost drink
Who cannot join
- Aged <18 or >55 years
- Unable to run for 30 min at a moderate-to-vigorous intensity without stopping
- A diagnosis or signs/symptoms of CVD or metabolic disorders
- Currently physically inactive (< 3 days/week of exercise at a moderate or higher intensity)
- Visual or hearing impairments interfering with ability to see and hear video clips
- Allergies to ingredients in Boost drink
Trial locations and contacts
1 site in 1 country.
United States1 site
Human Performance Laboratory
Norfolk, Virginia, 23529
About this study
Many athletes anecdotally report modifying their nutritional intake before competition in order to avoid gut problems, but no studies have evaluated whether emotional state impacts tolerance to pre-exercise feeding. Therefore, this study will use movie clips (stressful, horror, and funny/amusing) to induce different mood states and emotions, which will be followed by ingestion of food before endurance running on a treadmill. In addition, metabolic and physiologic responses to mood induction will be evaluated.
- Conditions
- Other Gastrointestinal Disorders, Cramp, Abdominal
- Being tested
- Funny/Amusing Video Clips, Horror/Scary Video Clips, Thrilling/Suspenseful Video Clips
- Medical subject headings
- Colic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Funny/Amusing Video ClipsOther
Participants watch 5-7 minutes of video clips that are funny/amusing in nature
Horror/Scary Video ClipsOther
Participants watch 5-7 minutes of video clips that are scary in nature
Thrilling/Suspenseful Video ClipsOther
Participants watch 5-7 minutes of video clips that are thrilling/suspenseful in nature
| Study group | Role | What they receive |
|---|---|---|
| Funny/Amusing Video Clips | Experimental | Participants will watch 5-7-min video clips that are meant to be funny/amusing Receives: Other: Funny/Amusing Video Clips |
| Horror/Scary Video Clips | Experimental | Participants will watch 5-7-min video clips that are meant to be scary Receives: Other: Horror/Scary Video Clips |
| Thrilling/Suspenseful Video Clips | Experimental | Participants will watch 5-7-min video clips that are meant to be thrilling/suspenseful Receives: Other: Thrilling/Suspenseful Video Clips |
What is being measured
The primary outcome is the main question the study is designed to answer.
Total exercise gastrointestinal symptom burden
The severity of several gastrointestinal symptoms will be assessed on a validated 0-10 scale. Ratings will be collected every 5 minutes during a 30-minute treadmill jogging/running test. Scores from every 5-minute collection will be summed to calculate total GI symptom scores.
Measured: Total GI symptom burden over a 30-minute jogging/running protocol.
Change in emotion ratings
Anxiety, fear, happiness, amusement, disgust, sadness, and anger on a 0-9 Likert scale. Emotions will be assessed before watching video clips and immediately after watching video clips.
Measured: Change in emotion ratings between immediately pre-video and immediately post-video.
Secondary outcomes (5)
Change over time in exercise heart rate
Heart rate will be measured with a chest-strap (Polar) monitor.
Measured: Heart rate will be measured throughout a 30-minute treadmill jogging/running test. Change over time will be evaluated using mixed ANOVA.
Substrate use
Carbohydrate and fat oxidation rates will be estimated from the volumes of oxygen consumption and carbon dioxide production during exercise
Measured: Carbohydrate and fat oxidation rates will be measured during the last 5 min of a 30-minute treadmill jogging/running test.
Feeling Scale
The Feeling Scale is a bipolar numerical rating scale ranging from -5 to +5, with descriptors of "very bad" at -5, "neutral" at 0, and "very good" at +5.
Measured: Ratings on the Feeling Scale will be measured at rest before watching video clips and throughout (every 5 min) a subsequent 30-minute treadmill jogging/running test.
Fatigue Scale
The Fatigue Scale is Likert-type scale that ranges from 0 (Not Fatigued at All) to 10 (Total Fatigue).
Measured: Ratings on the Fatigue Scale will be measured at rest before watching video clips and throughout (every 5 min) a subsequent 30-minute treadmill jogging/running test.
Heart rate post-video
Heart rate will be measured with a chest-strap (Polar) monitor.
Measured: Heart rate will be recorded immediately after videos are viewed.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Feb 2022
- Study start1 Apr 2022
- Primary completion2 Apr 2026
- Study completion2 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Other Gastrointestinal DisordersStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- Old Dominion University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Patrick Wilson, PhD, Old Dominion University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05217589
- Sponsor's protocol ID
- 21-180
- Status last verified
- Oct 2026
- First submitted
- 21 Dec 2021
- Last updated
- 16 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 16 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Influence of Different Mood States and Emotions on the Physiologic, Metabolic, and Perceptual Responses to Feeding Before Exercise
- ClinicalTrials.gov ID
- NCT05217589
- Acronym / sponsor ID
- 21-180
- Conditions
- Other Gastrointestinal Disorders, Cramp, Abdominal
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- Old Dominion UniversityUniversity, hospital or other
- Study start
- 1 Apr 2022 (actual)
- Primary completion
- 2 Apr 2026 (actual)
- Study completion
- 2 Apr 2026 (actual)
- First posted
- 1 Feb 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Many athletes anecdotally report modifying their nutritional intake before competition in order to avoid gut problems, but no studies have evaluated whether emotional state impacts tolerance to pre-exercise feeding. Therefore, this study will use movie clips (stressful, horror, and funny/amusing) to induce different mood states and emotions, which will be followed by ingestion of food before endurance running on a treadmill. In addition, metabolic and physiologic responses to mood induction will be evaluated.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Funny/Amusing Video Clips | Experimental | Other: Funny/Amusing Video ClipsParticipants will watch 5-7-min video clips that are meant to be funny/amusing |
| Horror/Scary Video Clips | Experimental | Other: Horror/Scary Video ClipsParticipants will watch 5-7-min video clips that are meant to be scary |
| Thrilling/Suspenseful Video Clips | Experimental | Other: Thrilling/Suspenseful Video ClipsParticipants will watch 5-7-min video clips that are meant to be thrilling/suspenseful |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Aged 18 to 55 years
- Able to run for 30 min at a moderate-to-vigorous intensity without stopping
- No diagnosis or signs/symptoms of cardiovascular disease (CVD) or metabolic disorders
- Currently physically active (at least 3 days/week of exercise at a moderate or higher intensity)
- No visual or hearing impairments interfering with ability to see and hear video clips
Key exclusion criteria (6 listed)
- Aged <18 or >55 years
- Unable to run for 30 min at a moderate-to-vigorous intensity without stopping
- A diagnosis or signs/symptoms of CVD or metabolic disorders
- Currently physically inactive (< 3 days/week of exercise at a moderate or higher intensity)
- Visual or hearing impairments interfering with ability to see and hear video clips
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Funny/Amusing Video ClipsParticipants watch 5-7 minutes of video clips that are funny/amusing in nature | Other | Funny/Amusing Video Clips |
| Horror/Scary Video ClipsParticipants watch 5-7 minutes of video clips that are scary in nature | Other | Horror/Scary Video Clips |
| Thrilling/Suspenseful Video ClipsParticipants watch 5-7 minutes of video clips that are thrilling/suspenseful in nature | Other | Thrilling/Suspenseful Video Clips |
Primary outcome
Total exercise gastrointestinal symptom burden
Time frame: Total GI symptom burden over a 30-minute jogging/running protocol.
The severity of several gastrointestinal symptoms will be assessed on a validated 0-10 scale. Ratings will be collected every 5 minutes during a 30-minute treadmill jogging/running test. Scores from every 5-minute collection will be summed to calculate total GI symptom scores.
Change in emotion ratings
Time frame: Change in emotion ratings between immediately pre-video and immediately post-video.
Anxiety, fear, happiness, amusement, disgust, sadness, and anger on a 0-9 Likert scale. Emotions will be assessed before watching video clips and immediately after watching video clips.
5 secondary outcomes
Change over time in exercise heart rate
Time frame: Heart rate will be measured throughout a 30-minute treadmill jogging/running test. Change over time will be evaluated using mixed ANOVA.
Substrate use
Time frame: Carbohydrate and fat oxidation rates will be measured during the last 5 min of a 30-minute treadmill jogging/running test.
Feeling Scale
Time frame: Ratings on the Feeling Scale will be measured at rest before watching video clips and throughout (every 5 min) a subsequent 30-minute treadmill jogging/running test.
Fatigue Scale
Time frame: Ratings on the Fatigue Scale will be measured at rest before watching video clips and throughout (every 5 min) a subsequent 30-minute treadmill jogging/running test.
Heart rate post-video
Time frame: Heart rate will be recorded immediately after videos are viewed.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Oct 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Funny/Amusing Video Clips, Horror/Scary Video Clips and Thrilling/Suspenseful Video Clips in people with Other Gastrointestinal Disorders and Cramp, Abdominal, run by Old Dominion University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Total exercise gastrointestinal symptom burden (time frame: Total GI symptom burden over a 30-minute jogging/running protocol.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Oct 2026.