Muscle AtrophyNCT05206253
Effectiveness of Egg Versus Whey Protein Powder During Resistance Training
A study testing Whole egg powder and Whey protein powder in people with Muscle Atrophy, run by University of Saskatchewan at 2 sites in Canada.
Trial summary
Consumption of whole eggs has recently been shown to stimulate muscle protein synthesis to a greater degree than consumption of egg whites after a resistance training session. It is theorized that the egg yoke contains bio-active nutrients that enhance the protein provided by egg whites. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Muscle Atrophy
- What is being tested?
- Whole egg powder and Whey protein powder
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 115 participants
- Where
- 2 sitesCanada
- Study dates
- 30 May 2022to 31 Aug 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Resistance training experience for at least one year
Who cannot join
- Having taken any nutritional supplements the past 30 days
- Currently using anabolic steroids
- Currently taking corticosteroids
- Allergies to dairy or egg products
- Identifying any medical conditions as determined by the "Get Active Questionnaire"
Trial locations and contacts
2 sites in 1 country.
Canada2 sites
University of Regina
Regina, Saskatchewan, S4S 0A2
University of Saskatchewan
Saskatoon, Saskatchewan, S7N5B2
About this study
Official title: Egg Versus Whey Protein as the Optimal Supplement for Fitness-conscious People
Consumption of whole eggs has recently been shown to stimulate muscle protein synthesis to a greater degree than consumption of egg whites after a resistance training session. It is theorized that the egg yoke contains bio-active nutrients that enhance the protein provided by egg whites. The study will evaluate the effect of whole egg powder compared to whey protein powder and placebo over 12 weeks of resistance training in men and women who are participating in resistance training programs.
Read the detailed description
Consuming whole eggs after resistance training sessions appears to be more effective for simulating muscle protein synthesis that simply consuming egg whites. The egg yolks might enhance the effect of protein derived from egg whites. The study will compare post-exercise supplementation with about 30 grams of protein derived from whole egg powder versus whey protein powder and placebo (maltodextrin) over a 12-week resistance training program. Resistance-trained men and women (n=120) will be randomized to consume either the whole-egg powder, whey protein powder or maltodextrin after resistance training 6 times per week for 12 weeks. The primary outcome measure is change in lean tissue mass. Secondary measures include change in fat mass, change in arm and leg muscle thickness, change in bench press, squat, and knee extension strength, and change in fasting blood glucose.
- Conditions
- Muscle Atrophy
- Being tested
- Whole egg powder, Whey protein powder, Maltodextrin placebo
- Medical subject headings
- Muscular Atrophy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Whole egg powderDietary supplement
Nutritional supplementation during a 12 week resistance training program
Whey protein powderDietary supplement
Nutritional supplementation during a 12 week resistance training program
Maltodextrin placeboDietary supplement
Nutritional supplementation during a 12 week resistance training program
| Study group | Role | What they receive |
|---|---|---|
| Whole egg powder | Experimental | Dietary supplementation with whole egg powder after resistance training sessions Receives: Dietary Supplement: Whole egg powder |
| Whey protein powder | Active comparator | Dietary supplementation with whey protein powder after resistance training sessions Receives: Dietary Supplement: Whey protein powder |
| Maltodextrin placebo | Placebo comparator | Dietary supplementation with maltodextrin placebo after resistance training sessions Receives: Dietary Supplement: Maltodextrin placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in lean tissue mass
Lean tissue mass measured by DXA
Measured: 12 weeks
Secondary outcomes (9)
Change in fat mass
Fat mass measured by DXA
Measured: 12 weeks
Change in biceps muscle thickness
biceps muscle thickness measured by ultrasound
Measured: 12 weeks
Change in triceps muscle thickness
triceps muscle thickness measured by ultrasound
Measured: 12 weeks
Change in quadriceps muscle thickness
quadriceps muscle thickness measured by ultrasound
Measured: 12 weeks
Change in hamstrings muscle thickness
hamstrings muscle thickness measured by ultrasound
Measured: 12 weeks
Change in bench press strength
Bench press strength (kg)
Measured: 12 weeks
Change in leg squat strength
Leg squat strength (kg)
Measured: 12 weeks
Change in knee extension strength
Isokinetic knee extension torque
Measured: 12 weeks
Change in fasting glucose
Fasting glucose
Measured: 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jan 2022
- Study start30 May 2022
- Primary completion31 Aug 2023
- Study completion31 Aug 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muscle AtrophyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 115 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Saskatchewan
- Sponsor type
- University, hospital or other
- Collaborators
- Egg Farmers of Canada
- Responsible party
- Principal investigator, Phil Chilibeck, University of Saskatchewan
- Investigators
- Philip Chilibeck, Ph.D., Principal investigator, University of SaskatchewanDarren Candow, Ph.D., Principal investigator, University of Regina
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05206253
- Sponsor's protocol ID
- Bio 2962
- Status last verified
- May 2024
- First submitted
- 11 Jan 2022
- Last updated
- 29 May 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 May 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Egg Versus Whey Protein as the Optimal Supplement for Fitness-conscious People
- ClinicalTrials.gov ID
- NCT05206253
- Acronym / sponsor ID
- Bio 2962
- Conditions
- Muscle Atrophy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 115 participants (actual)
- Lead sponsor
- University of SaskatchewanUniversity, hospital or other
- Collaborators
- Egg Farmers of Canada
- Study start
- 30 May 2022 (actual)
- Primary completion
- 31 Aug 2023 (actual)
- Study completion
- 31 Aug 2023 (actual)
- First posted
- 25 Jan 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Consumption of whole eggs has recently been shown to stimulate muscle protein synthesis to a greater degree than consumption of egg whites after a resistance training session. It is theorized that the egg yoke contains bio-active nutrients that enhance the protein provided by egg whites. The study will evaluate the effect of whole egg powder compared to whey protein powder and placebo over 12 weeks of resistance training in men and women who are participating in resistance training programs.
Detailed description
Consuming whole eggs after resistance training sessions appears to be more effective for simulating muscle protein synthesis that simply consuming egg whites. The egg yolks might enhance the effect of protein derived from egg whites. The study will compare post-exercise supplementation with about 30 grams of protein derived from whole egg powder versus whey protein powder and placebo (maltodextrin) over a 12-week resistance training program. Resistance-trained men and women (n=120) will be randomized to consume either the whole-egg powder, whey protein powder or maltodextrin after resistance training 6 times per week for 12 weeks. The primary outcome measure is change in lean tissue mass. Secondary measures include change in fat mass, change in arm and leg muscle thickness, change in bench press, squat, and knee extension strength, and change in fasting blood glucose.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Whole egg powder | Experimental | Dietary Supplement: Whole egg powderDietary supplementation with whole egg powder after resistance training sessions |
| Whey protein powder | Active comparator | Dietary Supplement: Whey protein powderDietary supplementation with whey protein powder after resistance training sessions |
| Maltodextrin placebo | Placebo comparator | Dietary Supplement: Maltodextrin placeboDietary supplementation with maltodextrin placebo after resistance training sessions |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Resistance training experience for at least one year
Key exclusion criteria (5 listed)
- Having taken any nutritional supplements the past 30 days
- Currently using anabolic steroids
- Currently taking corticosteroids
- Allergies to dairy or egg products
- Identifying any medical conditions as determined by the "Get Active Questionnaire"
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Whole egg powderNutritional supplementation during a 12 week resistance training program | Dietary supplement | Whole egg powder |
| Whey protein powderNutritional supplementation during a 12 week resistance training program | Dietary supplement | Whey protein powder |
| Maltodextrin placeboNutritional supplementation during a 12 week resistance training program | Dietary supplement | Maltodextrin placebo |
Primary outcome
Change in lean tissue mass
Time frame: 12 weeks
Lean tissue mass measured by DXA
9 secondary outcomes
Change in fat mass
Time frame: 12 weeks
Change in biceps muscle thickness
Time frame: 12 weeks
Change in triceps muscle thickness
Time frame: 12 weeks
Change in quadriceps muscle thickness
Time frame: 12 weeks
Change in hamstrings muscle thickness
Time frame: 12 weeks
Change in bench press strength
Time frame: 12 weeks
Change in leg squat strength
Time frame: 12 weeks
Change in knee extension strength
Time frame: 12 weeks
Change in fasting glucose
Time frame: 12 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 May 2024.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Philip Chilibeck, Ph.D. principal investigator
University of Saskatchewan
Darren Candow, Ph.D. principal investigator
University of Regina
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Whole egg powder and Whey protein powder in people with Muscle Atrophy, run by University of Saskatchewan at 2 sites in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 May 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in lean tissue mass (time frame: 12 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 May 2024.