Acute Coronary SyndromeEP-PARTICLESNCT05198492
Short- and Long-term Health Effects of Air Pollution in Poland
An observational study of Acute Coronary Syndrome and Atrial Fibrillation, run by Medical University of Bialystok at 1 site in Poland.
Trial summary
The effects of air pollution on the frequency of hospital admissions and mortality due to acute coronary syndromes, atrial fibrillation, and renal disfunction are noted also in areas perceived as pollution-free (due to the lack of large industry). Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Acute Coronary Syndrome, Atrial Fibrillation, Kidney Diseases
- What is being tested?
- Impact of air pollution
- How many people
- 8,300,000 participants
- Where
- 1 sitePoland
- Study dates
- 1 Jan 2011to 1 Dec 2030
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: The study population will be based on residents of Eastern Poland. This term covers 5 voivodships - Warmińsko-Mazurskie, Podlaskie, Lubelskie, Świętokrzyskie, Podkarpackie - with total area of 99,004 km2. The inhabitants of this region constitute 21.3% of the population of Poland and 1.6% of the population of the European Union. The area characterized by unique natural features, large areas covered by forests, lack of factories, and relatively low industrialization is not free of air pollution. As the region is also characterized by low socioeconomic status, in the cold season the residents' suboptimal heating choices are in result posing a major anthropogenic threat to air quality in the form of low emissions.
Who may be able to join
- Residents from the analyzed area
Who cannot join
- None
Trial locations and contacts
1 site in 1 country.
Poland1 site
Department of Invasive Cardiology, Medical University of Bialystok
Bialystok, Podlaskie Voivodeship, 15-276
About this study
The effects of air pollution on the frequency of hospital admissions and mortality due to acute coronary syndromes, atrial fibrillation, and renal disfunction are noted also in areas perceived as pollution-free (due to the lack of large industry). The aim of the project is to assess the impact of air pollution in Eastern Poland on regional public health.
Read the detailed description
The project will be conducted in Eastern Poland - the area characterized by unique natural features, large areas covered by forests, lack of factories, and relatively low industrialization. On the other hand, the region is also characterized by low socioeconomic status, in the cold season the residents' suboptimal heating choices are in result posing a major anthropogenic threat to air quality in the form of low emissions. The vast majority of studies on air pollution were conducted in highly polluted areas, in which patients are exposed to moderate and extreme concentrations of pollutants. Taking into consideration the scarce number of surveys from areas with a low level of pollution the investigators intend to analyze the relationship between air pollution and cardiovascular and renal outcomes in Eastern Poland. The examination of the impact of so-called "Polish smog" on mortality and morbidity in the study area is not without significance. It would be the first major study of the impact of this type of pollution on human health.
In the subsequent part of the study, we will evaluate the effects of Polish smog in the entire country.
In light of extant body of literature, the following will be considered as the public health indicators: acute coronary syndromes, episodes of atrial fibrillation, ischemic strokes, kidney disease hospitalizations or emergency room visits, cardiovascular and renal mortality.
- Conditions
- Acute Coronary Syndrome, Atrial Fibrillation, Kidney Diseases, Particulate Matter Inhalation Injury, Pollution; Exposure, Oxidative Stress
- Being tested
- Impact of air pollution
- Keywords
- Air Pollution, Public Health, Acute Coronary Syndromes, Atrial Fibrillation, Kidney Diseases, Particulate Matter, Cardiovascular Diseases
- Medical subject headings
- Acute Coronary Syndrome, Atrial Fibrillation, Kidney Diseases, Ischemic Stroke, Cardiovascular Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Impact of air pollutionOther
To assess the short- and long- term impact of air pollution
| Study group | Role | What they receive |
|---|---|---|
| Patients with hospitalizations or emergency room visits due to acute coronary syndromes | Data on hospitalization for acute coronary syndromes were obtained and extracted from the National Health Fund reports. In the present analysis, we used data from patients registered as residents in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020. The set of variables that were subjected to the analysis included demographic features and ICD-10 codes. The diagnosis was based on reports obtained from to the National Health Fund, and these reports have not been reviewed with patient hospital documentation. Receives: Other: Impact of air pollution | |
| Patients with hospitalizations or emergency room visits due to atrial fibrillation | Data on hospitalization for atrial fibrillation were obtained and extracted from the National Health Fund reports. In the present analysis, we used data from patients registered as residents in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020. The set of variables that were subjected to the analysis included demographic features and ICD-10 codes. The diagnosis was based on reports obtained from to the National Health Fund, and these reports have not been reviewed with patient hospital documentation. Receives: Other: Impact of air pollution | |
| Patients with hospitalizations or emergency room visits due to kidney diseases | Data on hospitalization for kidney diseases were obtained and extracted from the National Health Fund reports. In the present analysis, we used data from patients registered as residents in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020. The set of variables that were subjected to the analysis included demographic features and ICD-10 codes. The diagnosis was based on reports obtained from to the National Health Fund, and these reports have not been reviewed with patient hospital documentation. Receives: Other: Impact of air pollution | |
| Patients who died due to cardiovascular diseases | Data on mortality were collected from the National Statistical Office in Poland. These include information on all the deaths recorded in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020 The records included sex and age of people who had died, and the causes of deaths were classified according to codes in the International Classification of Diseases-10th Revision (ICD-10). Receives: Other: Impact of air pollution | |
| Patients who died due to neoplasm diseases | Data on mortality were collected from the National Statistical Office in Poland. These include information on all the deaths recorded in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020 The records included sex and age of people who had died, and the causes of deaths were classified according to codes in the International Classification of Diseases-10th Revision (ICD-10). Receives: Other: Impact of air pollution | |
| Patients who died due to kidney diseases | Data on mortality were collected from the National Statistical Office in Poland. These include information on all the deaths recorded in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020 The records included sex and age of people who had died, and the causes of deaths were classified according to codes in the International Classification of Diseases-10th Revision (ICD-10). Receives: Other: Impact of air pollution | |
| Patients with hospitalizations or emergency room visits due to ischemic strokes | Data on hospitalization for ischemic strokes were obtained and extracted from the National Health Fund reports. In the present analysis, we used data from patients registered as residents in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020. The set of variables that were subjected to the analysis included demographic features and ICD-10 codes. The diagnosis was based on reports obtained from to the National Health Fund, and these reports have not been reviewed with patient hospital documentation. Receives: Other: Impact of air pollution |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of acute coronary syndromes related to the impact of air pollution.
Short- and long- term influence of air pollution on the number of hospital admissions for acute coronary syndromes.
Measured: Through study completion, an average of 1 year
Number of atrial fibrillation episodes related to the impact of air pollution.
Short- and long- term influence of air pollution on the number of hospital admissions for atrial fibrillation.
Measured: Through study completion, an average of 1 year
Number of hospitalizations due to kidney diseases related to the impact of air pollution.
Long- term influence of air pollution on the number of hospital admissions for kidney disease.
Measured: Through study completion, an average of 1 year
Number of hospitalizations due to acute kidney diseases related to the impact of air pollution.
Long- term influence of air pollution on the number of hospital admissions for kidney disease.
Measured: Through study completion, an average of 1 year
Number of patients under hemodialysis related to the impact of air pollution.
Long- term influence of air pollution on the number of hospital admissions for kidney disease.
Measured: Through study completion, an average of 1 year
Number of ischemic strokes related to the impact of air pollution.
Short- and long- term influence of air pollution on the number of hospital admissions for ischemic strokes.
Measured: Through study completion, an average of 1 year
Secondary outcomes (3)
Cardiovascular mortality
Short- and long- term influence of air pollution on the number of cardiovascular mortality.
Measured: Through study completion, an average of 1 year
Neoplasm mortality
Short- and long- term influence of air pollution on neoplasm mortality.
Measured: Through study completion, an average of 1 year
Kidney disease mortality
Short- and long- term influence of air pollution on mortality related to renal function.
Measured: Through study completion, an average of 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jan 2022
- Study start1 Jan 2011
- Primary completion31 Dec 2020
- Study completion1 Dec 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (12)Papers the sponsor has linked to this study.
- Other trials for Acute Coronary SyndromeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 8,300,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Medical University of Bialystok
- Sponsor type
- University, hospital or other
- Collaborators
- Charles University, Czech Republic, University of Liverpool, University of Skopje, University of Lodz
- Responsible party
- Principal investigator, Lukasz Kuzma, Medical University of Bialystok
- Investigators
- Łukasz Kuźma, Study director, Medical University of Bialystok
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05198492
- Sponsor's protocol ID
- UMB-KKI-104
- Acronym
- EP-PARTICLES
- Status last verified
- Jun 2024
- First submitted
- 6 Jan 2022
- Last updated
- 21 Jun 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Kuzma L, Dabrowski EJ, Kurasz A, Bachorzewska-Gajewska H, Dobrzycki S. The 10-Year Study of the Impact of Particulate Matters on Mortality in Two Transit Cities in North-Eastern Poland (PL-PARTICLES). J Clin Med. 2020 Oct 27;9(11):3445. doi: 10.3390/jcm9113445.
PubMed 33120927Kuzma L, Struniawski K, Pogorzelski S, Bachorzewska-Gajewska H, Dobrzycki S. Gender Differences in Association between Air Pollution and Daily Mortality in the Capital of the Green Lungs of Poland-Population-Based Study with 2,953,000 Person-Years of Follow-Up. J Clin Med. 2020 Jul 23;9(8):2351. doi: 10.3390/jcm9082351.
PubMed 32717977Kuzma L, Malyszko J, Bachorzewska-Gajewska H, Kralisz P, Dobrzycki S. Exposure to air pollution and renal function. Sci Rep. 2021 Jun 1;11(1):11419. doi: 10.1038/s41598-021-91000-0.
PubMed 34075149Kuzma L, Wanha W, Kralisz P, Kazmierski M, Bachorzewska-Gajewska H, Wojakowski W, Dobrzycki S. Impact of short-term air pollution exposure on acute coronary syndrome in two cohorts of industrial and non-industrial areas: A time series regression with 6,000,000 person-years of follow-up (ACS - Air Pollution Study). Environ Res. 2021 Jun;197:111154. doi: 10.1016/j.envres.2021.111154. Epub 2021 Apr 17.
PubMed 33872649Kuzma L, Pogorzelski S, Struniawski K, Bachorzewska-Gajewska H, Dobrzycki S. Exposure to air pollution-a trigger for myocardial infarction? A nine-year study in Bialystok-the capital of the Green Lungs of Poland (BIA-ACS registry). Int J Hyg Environ Health. 2020 Aug;229:113578. doi: 10.1016/j.ijheh.2020.113578. Epub 2020 Aug 3.
PubMed 32758862Kuzma L, Pogorzelski S, Struniawski K, Dobrzycki S, Bachorzewska-Gajewska H. Effect of air pollution on the number of hospital admissions for acute coronary syndrome in elderly patients. Pol Arch Intern Med. 2020 Jan 31;130(1):38-46. doi: 10.20452/pamw.15064. Epub 2019 Nov 19.
PubMed 31742576Kuzma L, Dabrowski EJ, Kurasz A, Swieczkowski M, Jemielita P, Kowalewski M, Wanha W, Kralisz P, Tomaszuk-Kazberuk A, Bachorzewska-Gajewska H, Dobrzycki S, Lip GYH. Effect of air pollution exposure on risk of acute coronary syndromes in Poland: a nationwide population-based study (EP-PARTICLES study). Lancet Reg Health Eur. 2024 Apr 22;41:100910. doi: 10.1016/j.lanepe.2024.100910. eCollection 2024 Jun.
PubMed 38665621Swieczkowski M, Dobrzycki S, Kuzma L. Multi-City Analysis of the Acute Effect of Polish Smog on Cause-Specific Mortality (EP-PARTICLES Study). Int J Environ Res Public Health. 2023 Apr 18;20(8):5566. doi: 10.3390/ijerph20085566.
PubMed 37107848Wijata AM, Lip GYH, Kurasz A, Swieczkowski M, Jemielita P, Kralisz P, Dobrzycki S, Nalepa J, Kuzma L. Machine-learning-based cardiovascular mortality prediction using a cumulative PM2.5 exposure metric in high risk groups: a retrospective cohort study. Sci Rep. 2026 May 22;16(1):20533. doi: 10.1038/s41598-026-54080-4.
PubMed 42173944Swieczkowski M, Lip GYH, Kurasz A, Jemielita P, Duzinkiewicz M, Januszko T, Dobrzycki S, Kuzma L. Short-term exposure to air pollution and risk of ischemic stroke requiring intravenous thrombolysis: a population-level analysis in Poland from the EP-PARTICLES study. Environ Health. 2025 Sep 29;24(1):69. doi: 10.1186/s12940-025-01230-2.
PubMed 41024000Swieczkowski M, Lip GYH, Abohashem S, Jemielita P, Kurasz A, Duzinkiewicz M, Januszko T, Tomaszuk-Kazberuk A, Dobrzycki S, Kuzma L. Interplay between mental health, greenness, and environmental factors in cardiovascular mortality: insights from AIR-MIND. Eur J Prev Cardiol. 2025 Dec 23;32(18):1915-1927. doi: 10.1093/eurjpc/zwaf534.
PubMed 40884214Swieczkowski M, Lip GYH, Kurasz A, Dabrowski EJ, Tomaszuk-Kazberuk A, Kaminski JW, Struzewska J, Dobrzycki S, Kuzma L. Association between exposure to air pollution and increased ischaemic stroke incidence: a retrospective population-based cohort study (EP-PARTICLES study). Eur J Prev Cardiol. 2025 Mar 18;32(4):276-287. doi: 10.1093/eurjpc/zwae301.
PubMed 39301834