2 Years Prospective Study to Collect Real-life Data on the Retention, Quality of Life, Effectiveness and Treatment Pattern of Secukinumab in Adult Patients With Moderate to Severe Plaque Psoriasis, Psoriatic Arthritis, Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis

Retention rate is defined as percentage of patients who have not discontinued the medication.

Euro-QoL-5 Dimension Questionnaire (EQ-5D) is a standardized participant completed questionnaire that measures health-related quality of life and translates that score into an index value or utility score. EQ-5D health state profile is comprised of 5 dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 5 levels: 1= no problems, 2= slight problems, 3=moderate problems, 4= severe problems, and 5= extreme problems. Higher scores indicated greater levels of problems across each of the five dimensions.

Proportion of patients for each indication with alterations of secukinumab treatment regimen and reasons for.

Number of days of absenteeism from work/school due to health condition during each visit. Health condition which is considered to be related to the absenteeism will be determined by the treating physicians on the relationship with psoriasis, psoriatic arthritis or non-radiographic axial SpA or others conditions.

Psoriasis Area and Severity Index (PASI) takes into account the extent of the disease, as well as the severity of erythema, scaling, and thickness in different body areas affected by psoriasis.

• A PASI 75 represents an improvement in the PASI score of at least 75% as compared with baseline.
• A PASI 90 represents an improvement in the PASI score of at least 90% as compared with baseline.
• A PASI 100 response corresponds to complete clearing of psoriasis (PASI = 0).

Changes between PASI response categories over time after starting participation in the study to be collected.

Absolute PASI scores to be collected

Relative PASI, also called PASI response, is reported as a percent change from baseline PASI.

Absolute PASI is reported as a score to reflect the current status of severity of disease.

Physician Global Assessment (PGA) 0/1 response = clear/almost clear skin

Dermatology Life Quality Index (DLQI) is a ten item general dermatology disability index designed to assess health-related quality of life in adult participants with skin diseases such psoriasis. It is a self-administered questionnaire which includes domains of daily activity, leisure, personal relationships, symptoms and feelings, treatment and school/work activities. Each domain has 4 response categories ranging from 0 (not at all) 1 ( a little) to 3 (very much). "Not relevant" is a valid score also and is scored as 0.

Correlation analysis will be performed using Pearson's correlation or Spearman's correlation, depending on normality.

78 tender joint count (TJC) is determined by physical examination of 78 joint counts that are assessed for tenderness.

76 swollen joint count (SJC) is determined by physical examination of 76 joint counts that are classified as either swollen or not swollen.

VAS scale will be used to measure disease activity. The Visual Analog Scale (VAS) is a commonly used measurement of pain, discomfort, that goes from 0 meaning no pain to 100 meaning worst imaginable pain

The Visual Analog Scale (VAS) is a commonly used measurement of pain, discomfort, that goes from 0 meaning no pain to 100 meaning worst imaginable pain

Dactylitis is severe inflammation of the finger and toe joints.

Presence of any enthesitis in the following sites: lateral epicondyle humerus left and right, Achilles left and right and medial condyle femur left and right.

Enthesitis refers to inflammation of entheses, the site where ligaments or tendons insert into the bones.

Appearance of new bone erosions or worsening of pre-existing erosions in the hands and feet by X-ray assessment, according to the Treating Physician's opinion

Psoriasis Area and Severity Index (PASI) takes into account the extent of the disease, as well as the severity of erythema, scaling, and thickness in different body areas affected by psoriasis.

• A PASI 75 represents an improvement in the PASI score of at least 75% as compared with baseline.
• A PASI 90 represents an improvement in the PASI score of at least 90% as compared with baseline.
• A PASI 100 response corresponds to complete clearing of psoriasis (PASI = 0).

Changes between PASI response categories over time after starting participation in the study

Absolute PASI scores to be collected

Changes in absolute and relative PASI scores over time after inclusion into the study.

Health Assessment Questionnaire Disability Index (HAQ-DI) assesses a subject's level of functional ability and includes questions of fine movements of the upper extremity, locomotor activities of the lower extremity, and activities that involve both upper and lower extremities. There are 20 questions in 8 categories of functioning including dressing, rising, eating, walking, hygiene, reach, grip and usual activities. The stem of each item asks 'Over the past week, "are you able to..." perform a particular task'. Each item is scored on a 4 point scale from 0 - 3, representing normal, no difficulty (0), some difficulty (1), much difficulty (2) and unable to do (3). The disability index score is calculated as the mean of the available category scores, ranging from 0 to 3. A negative change from baseline indicates improvement.(Only at sites where HAQ-DI score is part of clinical routine).

The Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) assesses self-reported fatigue and its impact upon daily activities and function.

FACIT-Fatigue Scale: overall score (0 to 52)=the sum of scores for 13 questions. For each question, par. rated their condition for the past week on a 5-point scale: 0 (not at all) to 4 (very much). A high score indicates low fatigue.

(Only at sites where FACIT-Fatigue score is part of clinical routine).

Correlation analysis will be performed using Pearson's correlation or Spearman's correlation, depending on normality.

BASDAI is a participant-reported assessment consisting of 6 questions that relate to 5 major symptoms relevant to ankylosing spondylitis: 1) Fatigue, 2) Spinal pain, 3) Peripheral arthritis, 4) Enthesitis, 5) Intensity, and 6) Duration of morning stiffness. Participants need to score each item with a score from 0 to 10. Total score is obtained from the average of symptom scores ranging 0 (no problem) to 10 (worst problem), with a higher score indicating more severe symptoms.

Patient's global assessment of disease activity will be measured using VAS scale or NRS (numeric rating scale). NRS scale goes from 0 to 10 (0= no activity, 10= activity)

CRP or high-sensitivity CRP to be collected

The Visual Analog Scale (VAS) is a commonly used measurement of pain, discomfort, that goes from 0 meaning no pain to 100 meaning worst imaginable pain

Presence of any enthesitis in the following sites:

• Costochondral 1 right/left
• Costochondral 7 right/left
• Spina iliaca anterior superior right/left
• Crista iliaca right/left
• Spina iliaca posterior right/left
• Processus spinosus L5
• Achilles tendon, insertion right/left Enthesitis refers to inflammation of entheses, the site where ligaments or tendons insert into the bones.

Appearance or worsening, according to the treating physician's opinion, of any of the following lesions at anterior sites of the vertebrae assessed by X-ray (when available):

• Squaring
• Erosions
• Sclerosis
• Syndesmophytes
• Bridging syndesmophytes

Appearance or worsening (according to the Treating Physician's opinion) of bone marrow edema (BME) in the spine and/or sacro-iliac joints assessed by magnetic resonance imaging (MRI) (when available).

The Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) assesses self-reported fatigue and its impact upon daily activities and function.

FACIT-Fatigue Scale: overall score (0 to 52)=the sum of scores for 13 questions. For each question, par. rated their condition for the past week on a 5-point scale: 0 (not at all) to 4 (very much). A high score indicates low fatigue.

Data from BASDAI, patient's global assessment (NRS) and CRP/hsCRP can be used to calculate the AS disease activity score (ASDAS).

Correlation analysis will be performed using Pearson's correlation or Spearman's correlation, depending on normality.