Carpal Tunnel SyndromeNCT05150912
Mnaual Therapy in Treatment of Carpal Tunnel Syndrome
A study testing Manual therapy in people with Carpal Tunnel Syndrome, run by Cairo University at 1 site in Egypt.
Trial summary
2 groups of patients randomized for the treatment. Read more about this study
- Who is it for?
- Ages 45 to 55 years, women only
- Conditions the study is for
- Carpal Tunnel Syndrome
- What is being tested?
- Manual therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 412 participants
- Where
- 1 siteEgypt
- Study dates
- 26 Feb 2020to 24 May 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 55 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Pain and paresthesia at median nerve distribution ,positive tinel sign and positive phalen sign.
Who cannot join
- Any sensory and/or motor deficit in either ulnar or radial nerve
- age greater than 55 years .
- male sex.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Manual Therapy Based on Neurodynamic Techniques Versus Manual Therapy Including Desensitization Maneuvers With One Year Follow-up :Randomized Clinical Trial
2 groups of patients randomized for the treatment.
Read the detailed description
One group treated with neurodynamic techniques and the the other with the desensitization maneuvers.
- Conditions
- Carpal Tunnel Syndrome
- Being tested
- Manual therapy
- Medical subject headings
- Carpal Tunnel Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Manual therapyOther
strching neck
| Study group | Role | What they receive |
|---|---|---|
| Neuro dynamic | Active comparator | Neurodynamic techniques. Receives: Other: Manual therapy |
| desensitization | Active comparator | Desensitization maneuvers Receives: Other: Manual therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
PAIN and function
Boston carpal tunnel questionnaire (BCTQ) measure function and pain
Measured: after one year
muscle strength
measured by dynamometer to measure cylindrical grip and pincer grip
Measured: 3 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Dec 2021
- Study start26 Feb 2020
- Primary completion24 Sep 2021
- Study completion24 May 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Carpal Tunnel SyndromeStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 412 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sahar Ahmed Abdalbary, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05150912
- Sponsor's protocol ID
- Nahda University
- Status last verified
- Jul 2023
- First submitted
- 15 Nov 2021
- Last updated
- 19 Jul 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Mabrouk MI, Abdalbary SA, El-Shaarawy EAA, Elmahgoub S, Aburub A, Darabseh MZ, Makai A, Acs P. Neurodynamic techniques vs. desensitization maneuvers in the manual therapy management of moderate carpal tunnel syndrome among women: randomized clinical trial with 1-year follow-up. Front Pain Res (Lausanne). 2026 Jul 23;7:1792933. doi: 10.3389/fpain.2026.1792933. eCollection 2026.
PubMed 42592020
Study at a glance
From the registry record, last updated by the sponsor on 19 Jul 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Manual Therapy Based on Neurodynamic Techniques Versus Manual Therapy Including Desensitization Maneuvers With One Year Follow-up :Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT05150912
- Acronym / sponsor ID
- Nahda University
- Conditions
- Carpal Tunnel Syndrome
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 412 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 26 Feb 2020 (actual)
- Primary completion
- 24 Sep 2021 (actual)
- Study completion
- 24 May 2023 (actual)
- First posted
- 9 Dec 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
2 groups of patients randomized for the treatment.
Detailed description
One group treated with neurodynamic techniques and the the other with the desensitization maneuvers.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Neuro dynamic | Active comparator | Other: Manual therapyNeurodynamic techniques. |
| desensitization | Active comparator | Other: Manual therapyDesensitization maneuvers |
Who may qualify
- Ages
- 45 to 55 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Pain and paresthesia at median nerve distribution ,positive tinel sign and positive phalen sign.
Key exclusion criteria (3 listed)
- Any sensory and/or motor deficit in either ulnar or radial nerve
- age greater than 55 years .
- male sex.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Manual therapystrching neck | Other | Neuro dynamic, desensitization |
Primary outcome
PAIN and function
Time frame: after one year
Boston carpal tunnel questionnaire (BCTQ) measure function and pain
muscle strength
Time frame: 3 month
measured by dynamometer to measure cylindrical grip and pincer grip
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Jul 2023.
- Derived from this study: PubMed 42592020Mabrouk MI, Abdalbary SA, El-Shaarawy EAA, Elmahgoub S, Aburub A, Darabseh MZ, Makai A, Acs P. Neurodynamic techniques vs. desensitization maneuvers in the manual therapy management of moderate carpal tunnel syndrome among women: randomized clinical trial with 1-year follow-up. Front Pain Res (Lausanne). 2026 Jul 23;7:1792933. doi: 10.3389/fpain.2026.1792933. eCollection 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Manual therapy in people with Carpal Tunnel Syndrome, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 19 Jul 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
PAIN and function (time frame: after one year). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05150912, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Jul 2023.