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AgingNCT05042167

The Effect of Resistance Exercise on Inflammation in Young and Older Adults

A study testing Resistance exercise in people with Aging and Inflammatory Response, run by National Taiwan Normal University at 1 site in Taiwan.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected. Read more about this study

Who is it for?
Ages 20 to 80 years, men onlyHealthy volunteers can take part
Conditions the study is for
Aging, Inflammatory Response
What is being tested?
Resistance exercise
Could I receive a placebo?
No, everyone receives an active treatment
How many people
16 participants
Where
1 siteTaiwan
Study dates
1 Oct 2021to 31 Dec 2022
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 to 80 years
  • Men only
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • Age: 20-80
  • Healthy male
  • Without experience of resistance training

Who cannot join

  • No acute or chronic musculoskeletal symptoms
  • Smoking
  • Alcohol or drug abuse
  • Fail to conduct resistance exercise

Trial locations and contacts

1 site in 1 country.

Taiwan1 site

  • National Taiwan Normal University

    Taipei, 162

Other trials in Taiwan

About this study

Official title: The Acute Effect of High-load Resistance Exercise on Inflammation in Young and Older Adults

Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.

Being tested
Resistance exercise

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Resistance exerciseOther

    4 total resistance exercises that target all major muscle groups.

Study groups in NCT05042167
Study groupRoleWhat they receive
High-load resistance exerciseExperimentalSubjects in high-load trial performed 3 sets per exercise, 8 repetitions with load of 70%-1RM with 90 sec of rest between sets, followed by a fourth set to voluntary failure.
Receives: Other: Resistance exercise
Sedentary controlNo interventionSubjects in control trial stayed sedentary during the period.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Changes in biomarkers of inflammation

    Biomarkers of inflammation will be measured such as IL-10 in pg/mL, IL-6 in pg/mL, TNF-α in pg/mL.

    Measured: 24-hour during each study intervention

Secondary outcomes (6)

  1. Changes in glucose

    glucose in mg/dL

    Measured: 24-hour during each study intervention

  2. Changes in metabolic parameters

    Metabolic parameters will be measured such as TC in mg/dL, TG in mg/dL, and HDL in mg/dL.

    Measured: 24-hour during each study intervention

  3. Changes in biomarkers of muscle damage

    Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L.

    Measured: 24-hour during each study intervention

  4. Changes in molecular markers in peripheral blood mononuclear cells (PBMC)

    Molecular markers in PBMC will be measured such as STAT3 in arbitrary units, IKK in arbitrary units, IkB in arbitrary units, p65 in arbitrary units, SOCS3 in arbitrary units, AMPK in arbitrary units, and SIRT1 in arbitrary units.

    Measured: 24-hour during each study intervention

  5. Changes in complete blood count (CBC)

    The white blood cell count and the count of each white blood cell type will be measured.

    Measured: 24-hour during each study intervention

  6. Borgs Ratings of Perceived Exertion (RPE)

    Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion).

    Measured: 1-hour during each exercise intervention

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted13 Sep 2021
  2. Study start1 Oct 2021
  3. Primary completion31 Dec 2022
  4. Study completion31 Dec 2022

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Crossover
Masking
None (open label)
Enrolment
16 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05042167
Sponsor's protocol ID
202012HM020
Status last verified
Jan 2023
First submitted
2 Sep 2021
Last updated
13 Jan 2023
Results posted
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Tsai SH, Cheng HC, Little JP, Islam H, Liu HW. Elevated Plasma IL-6 Coincides with Activation of STAT3 in PBMC After Acute Resistance Exercise. Med Sci Sports Exerc. 2024 Nov 1;56(11):2117-2124. doi: 10.1249/MSS.0000000000003503.

    PubMed 39475859

Questions about this trial

What is this clinical trial studying?

A study testing Resistance exercise in people with Aging and Inflammatory Response, run by National Taiwan Normal University at 1 site in Taiwan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 13 Jan 2023. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Changes in biomarkers of inflammation (time frame: 24-hour during each study intervention). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05042167, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Jan 2023.

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