Memory DisordersBB2NCT05027789
Brain Boosters 2 in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention
A study testing Self-Guided and Structured Group in people with Memory Disorders and Cognitive Impairment, run by University of California, Davis at 1 site in United States.
Trial summary
The purpose of this research is to determine if training in memory support aids and healthy lifestyle activities (physical exercise, mentally stimulating activities and stress management) can have a positive effect on memory, thinking, and activities that people do every day. Read more about this study
- Who is it for?
- Ages 65 to 90 years
- Conditions the study is for
- Memory Disorders, Cognitive Impairment
- What is being tested?
- Self-Guided and Structured Group
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 263 participants
- Where
- 1 siteUnited States
- Study dates
- 13 Aug 2021to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 to 90 years
- All sexes
- No healthy volunteers
- Older adult
Who may be able to join
- The target population is cognitively normal older adults with Subjective Cognitive Concerns (SCC). SCC will be operationalized as
- a positive complaint in response to the question: 'Have you experienced a decline in your memory or other aspect of thinking in the last 1-3 years that seems worse than others of your age'
- normal cognition on the modified Telephone Interview of Cognitive Status (mTICS)
- independent function in daily life.
- Age 65 or older
- English speaking
Show all 9Show fewer
- Lower level of engagement in healthy lifestyle behaviors and compensation use at study baseline (i.e., broadly defined as not a regular exerciser)
- Approval from primary care (due to physical exercise component of the intervention)
- Open to utilizing digital tools such as a digital calendar in daily life
Who cannot join
- Known diagnosis of dementia or cognitive impairment;
- Other known neurological condition with potential to affect cognition (e.g., Parkinson's disease)
- Reported history of severe psychiatric disorder (e.g., self-reported history of bipolar disorder or schizophrenia or other psychotic disorder)
- Inability to complete the study protocols due to severe vision or hearing difficulties.
- Has previously participated in a previous version of Brain Boosters, or another study utilizing the Digital Memory Notebook (DMN) application or EMMA.
Trial locations and contacts
1 site in 1 country.
United States1 site
University of California, Davis Alzheimer's Disease Center
Sacramento, California, 95817
About this study
Official title: Compensation Training and Lifestyle Modifications to Promote Healthy Aging in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention (Brain Boosters 2)
The purpose of this research is to determine if training in memory support aids and healthy lifestyle activities (physical exercise, mentally stimulating activities and stress management) can have a positive effect on memory, thinking, and activities that people do every day. Participation in this study will involve being placed into one of two groups: a Self-Guided Intervention Group or a Structured Intervention Group. Both groups will be asked to attend group sessions in which they will be provided education on memory support strategies and lifestyle changes. The Structured Intervention Group will also be provided with an iPad and a digital application (called EMMA) to track their activity. Study participation involves a 6-month intervention and completing outcome measures at 4 different time points for up to a year.
Read the detailed description
Participants in this research will be asked to participate in group sessions about memory support strategies and healthy behaviors. They may also choose to have a partner participate in this study with them, but it is not required.
There will be weekly sessions for 10 weeks, followed by sessions 1 to 2 times per month for the next 4 months.
Participants will be asked to complete healthy lifestyle activities on their own. Before the intervention starts and at three time points after the intervention, we will collect cognitive assessments and questionnaires to measure the possible impact of the treatment. The post-intervention assessments will take place right after completion of the intervention, and then 6 and 12 months later.
Before the start of the study, participants will be required to get permission from their primary care provider to ensure that it is safe for them to complete physical aerobic exercise.
The Self-Guided and Structured Intervention Groups will be required to participate in the following study activities:
Intervention Training Sessions:
Participants will be asked to attend 15 information sessions that include:
- training on ways to help support memory like remembering appointments or taking medication and
- training on increasing interest in three health behaviors known to reduce risk of memory declines (physical exercise, mental stimulation, stress management).
These sessions will be in a group of up to 15 people and will last about 2 hours each. For 10 weeks, there will be sessions every week, and then for the next 4 months there will be 1-2 session each month.
There are two different versions of the intervention we are evaluating. Participants will be randomly assigned into one of the two groups. Both groups provide similar information about memory support strategies and lifestyle modifications to promote cognitive health.
Self-Guided Group
Participants in the self-guided group will:
- Receive education on memory support strategies and healthy lifestyles.
- Decide how they want to implement this information into their daily life.
- Receive information on various commercially available digital and other tools that might help them implement healthy changes in their life.
- The chance that participants will be in this group is random, like flipping a coin. One in every three participants will be enrolled in this group.
Structured Group
Participants in this group will:
- Receive specific recommended behavior targets (e.g., like how much exercise they should engage in each week).
- Receive an iPad to use throughout the study and follow up period with the digital application installed.
- Be asked to use the digital application to record their activity and to get reminders to complete this information.
Two in every three participants will receive the iPad and digital application.
Participants in this group will receive training on how to use the digital application.
Participants with their own iPad and/or smartphone can install the digital application on their personal iPad or smartphone if they prefer.
Both the Self-Guided and Structured groups will complete the following assessments:
Physical Assessment:
Cardiovascular health - This questionnaire will ask about age, sex, education, blood pressure, total cholesterol level, body-mass index and complete a short test of physical activity.
Cholesterol Test:
A blood test at the University of California Davis Pathology laboratory will be performed for any participant who has not had this test in the past year. Participants must fast overnight and have nothing but water for 12 hours before the blood test. Approximately 4 milliliters (or about 1 teaspoon) of blood will be drawn for this test.
Memory and Behavior Questionnaires:
Tests of memory and thinking and questionnaires about health and behaviors will be completed at the beginning of the study and three additional times (every 6 months). Study partners will also be asked to complete some questionnaires about the participant.
Participants who are randomized to the Structured Intervention Group will also be asked to complete these additional assessments:
- Week-Long Assessment:
- Structured Intervention Group participants will be asked to complete daily assessments for one week at four different times during participation. This will include questions about the experience with EMMA and some short memory and thinking assessments.
- Digital application (EMMA) Experiences Interview:
- A subset of participants in the Structured Intervention Group will be asked to complete an interview about their experience with using EMMA. This interview will occur over the telephone or video conferencing (such as Zoom) and will be recorded for scoring and quality assurances. The researchers will keep these recordings until the study is complete (about 5 years). This is completely voluntary, and participants can choose not to complete the interview.
- Conditions
- Memory Disorders, Cognitive Impairment
- Being tested
- Self-Guided, Structured Group
- Medical subject headings
- Memory Disorders, Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Self-GuidedBehavioural
People in this arm will come to 15 information sessions. These sessions will provide training and education on memory support strategies and healthy lifestyles. You will decide how you want to implement this information into your daily life.
Structured GroupBehavioural
People in this group will come to 15 information sessions. The study will provide recommended behavior targets (like how much exercise you should have each week). Participants in this group will either receive an iPad or have a special application installed on their own personal device. They will receive training on how to use the application, and will be asked to use the application to record their activities and receive reminders.
| Study group | Role | What they receive |
|---|---|---|
| Self-Guided Group | Active comparator | Subjects in this group will be provided education on memory support strategies and healthy lifestyles. Participants will decide how they want to implement this information into their daily lives. The study will also provide information on various commercially available digital and other tools that might help participants implement healthy changes their lives. One in every three participants will be enrolled in this group (selected randomly). Receives: Behavioral: Self-Guided |
| Structured Group | Active comparator | Subjects in this group will will be provided with specific recommended behavior targets (e.g., like how much exercise you should engage in each week). Participants will also receive an iPad to use throughout the study and follow up period with the digital application installed. Subjects will be asked to use the digital application to record their activity and to receive reminders to complete this information. Two in every three participants will receive the iPad and digital application. Participants in this group will receive training on how to use the digital application. The researchers can install the digital application on the subjects' personal iPad or smartphone if they prefer. Receives: Behavioral: Structured Group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Logical Memory
A standardized assessment of narrative episodic memory.
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Free and Cued Selective Reminding Test (FCRT)
A standardized assessment of immediate and delayed memory by using cues or free recall
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Digit Span
A standardized assessment of attention and working memory by recalling short lists of numbers immediately in either forward or backwards order.
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Trail Making
A standardized assessment of executive functioning by assessing following order but switching between letters and numbers.
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Digit Symbol
A standardized assessment of executive functioning by having participants match symbols and letters.
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Verbal Fluency
A standardized assessment of executive functioning by having participants list as many words they can that start with a specific letter.
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Royal Prince Alfred Prospective Memory Test
A standardized assessment of prospective memory by asking participants to remind the examiner of a task at different intervals throughout the session.
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Everyday Function
Evaluates participants everyday cognition through a variety of self-report questions about their daily functioning.
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Secondary outcomes (14)
Coping Self efficacy (CSES)
Questionnaire measuring perceived self-efficacy for coping with challenges and threats
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Center for Epidemiologic Studies Depression Scale (CES-D)
Self-report measure of depression
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Perceived Stress Scale (PSS)
Self-report measure of stress
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Satisfaction with Life
Self-report measure of life satisfaction
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Purpose in Life
Self-report measure of life purpose
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Short Physical Performance Battery
Measures gait speed, balance and sit to stand
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Brief Resiliency Scale (BRS)
Self-reported measure of resilience
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Patient Reported Outcomes Measurement Information System (PROMIS) General Health and Quality of Life Measure
two question scale assessing feelings on general health and quality of life.
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Cooperative Study Activities of Daily Living (ADL) Prevention Instrument (ADCS-ADL-PI)
questionnaire measuring functional abilities (e.g., managing finances, medication, shopping, laundry)
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Everyday Compensation (EComp)
Questionnaire measuring the behavioral compensatory strategies in the context of performing tasks like managing finances, medication, shopping, laundry, etc.
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Community Healthy Activities Model Program for Seniors (CHAMPS)
Questionnaire measuring frequency and duration of various physical activities and cognitively stimulating activity
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Positive Affect and Negative Affect Scale (PANAS)
Questionnaire measuring of positive and negative affect
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
The Gratitude Questionnaire - Six Item Form
Questionnaire measuring the frequency of feelings of gratitude
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Mindfulness Inventory
Questionnaire measuring the construct of mindfulness in daily life (e.g. being aware of thoughts and feelings as well as external events).
Measured: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Aug 2021
- Study start13 Aug 2021
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Memory DisordersStudies of the same condition, open and under way.
- More trials run by University of California, DavisThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This project will utilize a randomized controlled trial (RCT) design with single blinding (outcomes examiner) comparing the structured intervention (combined structured training in compensation and lifestyle modification, assisted by the EMMA) to the self-guided intervention group, which focuses on providing education and allowing participants to choose how to implement the information was chosen to account for the impact of two general factors: 1) the provision of information, and 2) the social support and stimulation provided by attending a group-based intervention.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 263 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of California, Davis
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Responsible party
- Sponsor
- Investigators
- Sarah Farias, PhD, Principal investigator, University of California, Davis
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05027789
- Sponsor's protocol ID
- 1764579
- Other IDs
- 1R01AG066748-01A1
- Acronym
- BB2
- Status last verified
- Oct 2026
- First submitted
- 5 Aug 2021
- Last updated
- 13 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Tomaszewski Farias S, Fox J, Dulaney H, Chan M, Namboodiri S, Harvey DJ, Weakley A, Rahman S, Luna C, Beech BF, Campbell L, Schmitter-Edgecombe M. Memory support training and lifestyle modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention (Brain Boosters). BMC Geriatr. 2023 Dec 21;23(1):881. doi: 10.1186/s12877-023-04574-x.
PubMed 38129775
Study at a glance
From the registry record, last updated by the sponsor on 13 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Compensation Training and Lifestyle Modifications to Promote Healthy Aging in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention (Brain Boosters 2)
- ClinicalTrials.gov ID
- NCT05027789
- Acronym / sponsor ID
- BB2 / 1764579
- Conditions
- Memory Disorders, Cognitive Impairment
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 263 participants (estimated)
- Lead sponsor
- University of California, DavisUniversity, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Study start
- 13 Aug 2021 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 30 Aug 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this research is to determine if training in memory support aids and healthy lifestyle activities (physical exercise, mentally stimulating activities and stress management) can have a positive effect on memory, thinking, and activities that people do every day. Participation in this study will involve being placed into one of two groups: a Self-Guided Intervention Group or a Structured Intervention Group. Both groups will be asked to attend group sessions in which they will be provided education on memory support strategies and lifestyle changes. The Structured Intervention Group will also be provided with an iPad and a digital application (called EMMA) to track their activity. Study participation involves a 6-month intervention and completing outcome measures at 4 different time points for up to a year.
Detailed description
Participants in this research will be asked to participate in group sessions about memory support strategies and healthy behaviors. They may also choose to have a partner participate in this study with them, but it is not required.
There will be weekly sessions for 10 weeks, followed by sessions 1 to 2 times per month for the next 4 months.
Participants will be asked to complete healthy lifestyle activities on their own. Before the intervention starts and at three time points after the intervention, we will collect cognitive assessments and questionnaires to measure the possible impact of the treatment. The post-intervention assessments will take place right after completion of the intervention, and then 6 and 12 months later.
Before the start of the study, participants will be required to get permission from their primary care provider to ensure that it is safe for them to complete physical aerobic exercise.
The Self-Guided and Structured Intervention Groups will be required to participate in the following study activities:
Intervention Training Sessions:
Participants will be asked to attend 15 information sessions that include:
- training on ways to help support memory like remembering appointments or taking medication and
- training on increasing interest in three health behaviors known to reduce risk of memory declines (physical exercise, mental stimulation, stress management).
These sessions will be in a group of up to 15 people and will last about 2 hours each. For 10 weeks, there will be sessions every week, and then for the next 4 months there will be 1-2 session each month.
There are two different versions of the intervention we are evaluating. Participants will be randomly assigned into one of the two groups. Both groups provide similar information about memory support strategies and lifestyle modifications to promote cognitive health.
Self-Guided Group
Participants in the self-guided group will:
- Receive education on memory support strategies and healthy lifestyles.
- Decide how they want to implement this information into their daily life.
- Receive information on various commercially available digital and other tools that might help them implement healthy changes in their life.
- The chance that participants will be in this group is random, like flipping a coin. One in every three participants will be enrolled in this group.
Structured Group
Participants in this group will:
- Receive specific recommended behavior targets (e.g., like how much exercise they should engage in each week).
- Receive an iPad to use throughout the study and follow up period with the digital application installed.
- Be asked to use the digital application to record their activity and to get reminders to complete this information.
Two in every three participants will receive the iPad and digital application.
Participants in this group will receive training on how to use the digital application.
Participants with their own iPad and/or smartphone can install the digital application on their personal iPad or smartphone if they prefer.
Both the Self-Guided and Structured groups will complete the following assessments:
Physical Assessment:
Cardiovascular health - This questionnaire will ask about age, sex, education, blood pressure, total cholesterol level, body-mass index and complete a short test of physical activity.
Cholesterol Test:
A blood test at the University of California Davis Pathology laboratory will be performed for any participant who has not had this test in the past year. Participants must fast overnight and have nothing but water for 12 hours before the blood test. Approximately 4 milliliters (or about 1 teaspoon) of blood will be drawn for this test.
Memory and Behavior Questionnaires:
Tests of memory and thinking and questionnaires about health and behaviors will be completed at the beginning of the study and three additional times (every 6 months). Study partners will also be asked to complete some questionnaires about the participant.
Participants who are randomized to the Structured Intervention Group will also be asked to complete these additional assessments:
- Week-Long Assessment:
- Structured Intervention Group participants will be asked to complete daily assessments for one week at four different times during participation. This will include questions about the experience with EMMA and some short memory and thinking assessments.
- Digital application (EMMA) Experiences Interview:
- A subset of participants in the Structured Intervention Group will be asked to complete an interview about their experience with using EMMA. This interview will occur over the telephone or video conferencing (such as Zoom) and will be recorded for scoring and quality assurances. The researchers will keep these recordings until the study is complete (about 5 years). This is completely voluntary, and participants can choose not to complete the interview.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- This project will utilize a randomized controlled trial (RCT) design with single blinding (outcomes examiner) comparing the structured intervention (combined structured training in compensation and lifestyle modification, assisted by the EMMA) to the self-guided intervention group, which focuses on providing education and allowing participants to choose how to implement the information was chosen to account for the impact of two general factors: 1) the provision of information, and 2) the social support and stimulation provided by attending a group-based intervention.
| Arm | Type | Receives |
|---|---|---|
| Self-Guided Group | Active comparator | Behavioral: Self-GuidedSubjects in this group will be provided education on memory support strategies and healthy lifestyles. Participants will decide how they want to implement this information into their daily lives. The study will also provide information on various commercially available digital and other tools that might help participants implement healthy changes their lives. One in every three participants will be enrolled in this group (selected randomly). |
| Structured Group | Active comparator | Behavioral: Structured GroupSubjects in this group will will be provided with specific recommended behavior targets (e.g., like how much exercise you should engage in each week). Participants will also receive an iPad to use throughout the study and follow up period with the digital application installed. Subjects will be asked to use the digital application to record their activity and to receive reminders to complete this information. Two in every three participants will receive the iPad and digital application. Participants in this group will receive training on how to use the digital application. The researchers can install the digital application on the subjects' personal iPad or smartphone if they prefer. |
Who may qualify
- Ages
- 65 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Older adult
Key inclusion criteria (9 listed)
- The target population is cognitively normal older adults with Subjective Cognitive Concerns (SCC). SCC will be operationalized as
- Age 65 or older
- English speaking
- Lower level of engagement in healthy lifestyle behaviors and compensation use at study baseline (i.e., broadly defined as not a regular exerciser)
- Approval from primary care (due to physical exercise component of the intervention)
Key exclusion criteria (5 listed)
- Known diagnosis of dementia or cognitive impairment;
- Other known neurological condition with potential to affect cognition (e.g., Parkinson's disease)
- Reported history of severe psychiatric disorder (e.g., self-reported history of bipolar disorder or schizophrenia or other psychotic disorder)
- Inability to complete the study protocols due to severe vision or hearing difficulties.
- Has previously participated in a previous version of Brain Boosters, or another study utilizing the Digital Memory Notebook (DMN) application or EMMA.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Self-GuidedPeople in this arm will come to 15 information sessions. These sessions will provide training and education on memory support strategies and healthy lifestyles. You will decide how you want to implement this information into your daily life. | Behavioural | Self-Guided Group |
| Structured GroupPeople in this group will come to 15 information sessions. The study will provide recommended behavior targets (like how much exercise you should have each week). Participants in this group will either receive an iPad or have a special application installed on their own personal device. They will receive training on how to use the application, and will be asked to use the application to record their activities and receive reminders. | Behavioural | Structured Group |
Primary outcome
Logical Memory
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
A standardized assessment of narrative episodic memory.
Free and Cued Selective Reminding Test (FCRT)
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
A standardized assessment of immediate and delayed memory by using cues or free recall
Digit Span
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
A standardized assessment of attention and working memory by recalling short lists of numbers immediately in either forward or backwards order.
Trail Making
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
A standardized assessment of executive functioning by assessing following order but switching between letters and numbers.
Digit Symbol
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
A standardized assessment of executive functioning by having participants match symbols and letters.
Verbal Fluency
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
A standardized assessment of executive functioning by having participants list as many words they can that start with a specific letter.
Royal Prince Alfred Prospective Memory Test
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
A standardized assessment of prospective memory by asking participants to remind the examiner of a task at different intervals throughout the session.
Everyday Function
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Evaluates participants everyday cognition through a variety of self-report questions about their daily functioning.
14 secondary outcomes
Coping Self efficacy (CSES)
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Center for Epidemiologic Studies Depression Scale (CES-D)
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Perceived Stress Scale (PSS)
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Satisfaction with Life
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Purpose in Life
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Short Physical Performance Battery
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Brief Resiliency Scale (BRS)
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Patient Reported Outcomes Measurement Information System (PROMIS) General Health and Quality of Life Measure
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Cooperative Study Activities of Daily Living (ADL) Prevention Instrument (ADCS-ADL-PI)
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Everyday Compensation (EComp)
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Community Healthy Activities Model Program for Seniors (CHAMPS)
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Positive Affect and Negative Affect Scale (PANAS)
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
The Gratitude Questionnaire - Six Item Form
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Mindfulness Inventory
Time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Oct 2026.
- Derived from this study: PubMed 38129775Tomaszewski Farias S, Fox J, Dulaney H, Chan M, Namboodiri S, Harvey DJ, Weakley A, Rahman S, Luna C, Beech BF, Campbell L, Schmitter-Edgecombe M. Memory support training and lifestyle modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention (Brain Boosters). BMC Geriatr. 2023 Dec 21;23(1):881. doi: 10.1186/s12877-023-04574-x.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Sarah Farias, PhD principal investigator
University of California, Davis
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Self-Guided and Structured Group in people with Memory Disorders and Cognitive Impairment, run by University of California, Davis at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 13 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Logical Memory (time frame: Change in assessment scores from baseline to 6-months, 12-months, and 18-months). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05027789, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Oct 2026.