Cardiovascular RiskPhase 3ZEUSNCT05021835
ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
A Phase 3 study testing Ziltivekimab B and Ziltivekimab C in people with Cardiovascular Risk and Chronic Kidney Disease, run by Novo Nordisk A/S at 1,073 sites in 38 countries.
Trial summary
This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiovascular Risk, Chronic Kidney Disease, Inflammation
- What is being tested?
- Ziltivekimab B and Ziltivekimab C
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 6,385 participants
- Where
- 1,073 sitesin 38 countries
- Study dates
- 30 Aug 2021to 9 Jun 2026
- Phase
- Phase 3
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Chronic kidney disease defined by one of the below:
- Estimated glomerular filtration rate (eGFR) greater than or equal to (>=) 15 and below 60 mL/min/1.73 m^2 (using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation)
- Urinary albumin-to-creatinine ratio (UACR) >= 200 milligrams per gram (mg/g) and eGFR >= 60 mL/min/1.73 m2 (using the CKD-EPI creatinine equation)
- Serum high-sensitivity C-reactive protein (hs-CRP) greater than or equal to 2 milligram per liter (mg/L)
- Evidence of atherosclerotic cardiovascular disease (ASCVD) by one or more of the following:
- Coronary heart disease defined as at least one of the following: i. Documented history of MI ii. Prior coronary revascularisation procedure iii. greater than or equal to 50% stenosis in major epicardial coronary artery documented by cardiac catheterisation or CT coronary angiography b) Cerebrovascular disease defined as at least one of the following: i. Prior stroke of atherosclerotic origin ii. Prior carotid artery revascularisation procedure iii. greater than or equal to 50% stenosis in carotid artery documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound.
- Symptomatic peripheral artery disease (PAD) defined as at least one of the following: i. Intermittent claudication with an ankle-brachial index (ABI) below or equal to 0.90 at rest ii. Intermittent claudication with a greater than or equal to 50% stenosis in peripheral artery (excluding carotid) documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound iii. Prior peripheral artery (excluding carotid) revascularisation procedure iv. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g. trauma or osteomyelitis).
Who cannot join
- Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.
- Myocardial infarction, stroke, hospitalisation for unstable angina pectoris, or transient ischaemic attack within 60 days prior to randomisation (visit 2).
- Planned coronary, carotid or peripheral artery revascularisation known on the day of randomisation (visit 2).
- Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit 2) or any major surgical procedure planned at the time of randomisation (visit 2).
Trial locations and contacts
1,073 sites in 38 countries.
1073 sites in 38 countries
United States181 sites
Javara/Privia Med Grp GA,LLC
Albany, Georgia, 31707
Uni of New Mexico-Clinical
Albuquerque, New Mexico, 87106
Anne Arundel Medical Center
Annapolis, Maryland, 21401
Liberty Research Center
Arlington, Texas, 76002
Arlington Family Res. Ctr Inc
Arlington, Texas, 76012-4637
Endeavor Health Clinical Operations-NCH
Arlington Heights, Illinois, 60005
Mountain Kidney & Hypertension Associates
Asheville, North Carolina, 28801
Southeastern Clinical R.I.
Augusta, Georgia, 30904
Southeastern Clinical Research Institute, LLC
Augusta, Georgia, 30904
Novel Research LLC
Bellaire, Texas, 77401
Suburban Hospital
Bethesda, Maryland, 20814
Northeast Clinical Research Center
Bethlehem, Pennsylvania, 18017
National Heart Institute Cal
Beverly Hills, California, 90211
Uni of Alabama at Birmingham
Birmingham, Alabama, 35233
Excel Med Ctr Clinical Trials
Boca Raton, Florida, 33434
Grace Research, LLC
Bossier City, Louisiana, 71111
Brigham & Women's Hospital
Boston, Massachusetts, 02115-5804
Florida Premier Cardiology
Boynton Beach, Florida, 33437
Bridgeport Hospital
Bridgeport, Connecticut, 06610
Advanced Heart Care LLC
Bridgewater, New Jersey, 08807-3064
Kernodle Clin Dpt-Pvt Diagnost
Burlington, North Carolina, 27215
UNC- Chapel Hill
Chapel Hill, North Carolina, 27599
Metrolina Nephrology Associates, PA
Charlotte, North Carolina, 28208
Javara Inc._Charlotte
Charlotte, North Carolina, 28210
Univ Diab & Endo Consultants
Chattanooga, Tennessee, 37411
Research by Design LLC
Chicago, Illinois, 60643
California Inst Of Renal Res
Chula Vista, California, 91910
California Institute of Renal Research #10
Chula Vista, California, 91910
Univ of Cincinnati Med Cent
Cincinnati, Ohio, 45219
Innovative Research of W FL
Clearwater, Florida, 33756
VA Northeast Ohio Healthcare System (VANEOHS)
Cleveland, Ohio, 44106
John P Hakim MD and Associates
Clinton, Maryland, 20735
Hope Clin Res & Wellness
Conyers, Georgia, 30094
Osvaldo A. Brusco MD
Corpus Christi, Texas, 78414
Valley Clinical Trials
Covina, California, 91723
Research Trials Worldwide LLC
Cypress, Texas, 77429
Renal Disease Research Institute
Dallas, Texas, 75204
Thyroid Endocrinology & Diabetes PA
Dallas, Texas, 75208
Liberty Research Center_Dallas
Dallas, Texas, 75230
Denver Health Outpatient Medical Center
Denver, Colorado, 80204
Henry Ford Hospital_Detroit
Detroit, Michigan, 48202
DHR Health Inst for Res & Dev
Edinburg, Texas, 78539
Academy of Diabetes, T&E
El Paso, Texas, 79935
MediSphere Medical RC
Evansville, Indiana, 47714
Lillestol Research LLC
Fargo, North Dakota, 58104
Javara Inc._Albany
Fayetteville, Georgia, 30214
Northeast Research Institute
Fleming Island, Florida, 32003
Elite Research Center
Flint, Michigan, 48532
Javara Inc/Privia Md GpLLC Fst
Forest, Virginia, 24551
Care United Research, LLC
Forney, Texas, 75126
Integrative Research Assoc Inc
Fort Lauderdale, Florida, 33312
Piedmont Research Partners, LLC
Fort Mill, South Carolina, 29707
Diabetes and Thyroid Ctr of FW
Fort Worth, Texas, 76132
Javara /TX.Hlth LLC dba Prvia
Fort Worth, Texas, 76133
Lenzmeier Fam Med CCT Research
Glendale, Arizona, 85308
Healthy Heart Cardiology
Grand Rapids, Michigan, 49546
Balad Hlth Sys-Welmont CardCVA
Greeneville, Tennessee, 37745
PharmQuest Life Sciences LLC
Greensboro, North Carolina, 27408
Physicians East Endocrinology
Greenville, North Carolina, 27834
Palmetto Clinical Research
Greenville, South Carolina, 29615
Clinical Invest Special_Gurnee
Gurnee, Illinois, 60031
Mass General Community Physicians
Haverhill, Massachusetts, 01830
Chicago Medical Research LLC
Hazel Crest, Illinois, 60429
Elixia Pines
Hollywood, Florida, 33024
Encore Medical Research LLC
Hollywood, Florida, 33024
PrimeCare Medical Group
Houston, Texas, 77024
Baylor College Of Medicine_Houston, Travis Street
Houston, Texas, 77030
Baylor College Of Medicine_Houston
Houston, Texas, 77030
Biopharma Informatic_Houston
Houston, Texas, 77043
Prolato Clinical Research Center
Houston, Texas, 77054
Prolato Clinical Research Cntr
Houston, Texas, 77054
Card Specialists of Willowbrook
Houston, Texas, 77070
PlanIt Research, PLLC
Houston, Texas, 77079
Biopharma Informatic, LLC
Houston, Texas, 77084
Biopharma Informatic_Houston_0
Houston, Texas, 77090
Valiance Clinical Research
Huntington Park, California, 90255
Northeast Research Institute
Jacksonville, Florida, 32204
Est Cst Inst for Rsrch,Jksnvil
Jacksonville, Florida, 32216
Baptist Heart Specialists
Jacksonville, Florida, 32258
NSC Research, Inc
Johns Creek, Georgia, 30024
Clinical Research Consultants, LLC
Kansas City, Missouri, 64111
Tennova HC Turkey Creek MC
Knoxville, Tennessee, 37934
Scripps Wht Diab Inst La Jolla
La Jolla, California, 92037
Balboa Nephro Med Gr Inc LaMes
La Mesa, California, 91942
Clinical Research of Cent FL
Lakeland, Florida, 33805
First Valley Medical Group
Lancaster, California, 93534
University of Nevada School of Medicine
Las Vegas, Nevada, 89102
Palm Research Center Inc-Vegas
Las Vegas, Nevada, 89128
Lexington VA Health Care System
Lexington, Kentucky, 40502
The Research Group of Lexington LLC
Lexington, Kentucky, 40503
Nebraska Heart Institute_Lincoln
Lincoln, Nebraska, 68526
Ocean St Clin Res Partnrs, LLC
Lincoln, Rhode Island, 02865
Univ of Arkansas Med Sciences
Little Rock, Arkansas, 72205
VA Loma Linda Hlthcr Sys
Loma Linda, California, 92357
DCOL Ctr for Clin Res
Longview, Texas, 75605
Pacific Clinical Studies
Los Alamitos, California, 90720
Angel City Research, Inc.
Los Angeles, California, 90010
Norton Heart Specialists-Springs
Louisville, Kentucky, 40205
Texas Inst, Kdny & Endo Disor
Lufkin, Texas, 75904
North America Research Institute
Lynwood, California, 90262
Advanced Med Res Maumee
Maumee, Ohio, 43537
RGV Endocrine Center
McAllen, Texas, 78503
Clinical Neuroscience Solutions
Memphis, Tennessee, 38119
Aventiv Research Inc.
Mesa, Arizona, 85206
Pharmax Research Clinic
Miami, Florida, 33126
Life Spring Research Foundation LLC
Miami, Florida, 33130
Allied Biomedical Research
Miami, Florida, 33155
San Marcus Res Clin Miami Lakes
Miami Lakes, Florida, 33014
NYU Nephrology Associates
Mineola, New York, 11501
AHS dba Abbot NW Hosp Diab Cen
Minneapolis, Minnesota, 55407
University of Minnesota_Minneapolis_1
Minneapolis, Minnesota, 55455
Office of Kenneth Blaze DO
Miramar, Florida, 33027
Clinical Trials of Ame, LLC
Monroe, Louisiana, 71201
IMA Clinical Research
Monroe, Louisiana, 71201
Chambliss Clinical Trials LLC
Montgomery, Alabama, 36106
Carteret Medical Group
Morehead City, North Carolina, 28557
Family Medicine of SayeBrook LLC
Myrtle Beach, South Carolina, 29588
Saltzer Medical Group Research
Nampa, Idaho, 83686-6011
Suncoast Clin Res Port Richey
New Port Richey, Florida, 34652
NYU Grossman School of Med
New York, New York, 10016
Mount Sinai Hosp at NYC
New York, New York, 10019
Hoag Medical Group
Newport Beach, California, 92663
York Clinical Research LLC
Norfolk, Virginia, 23504
Northport VA Med Ctr Northport
Northport, New York, 11768
Valley Clinical Trials, Inc.
Northridge, California, 91325
VA NEB - Western IA Health Stm
Omaha, Nebraska, 68105
Methodist Phys Clin Heart Cons
Omaha, Nebraska, 68114
Univ of Nebraska Medical CTR
Omaha, Nebraska, 68198-3020
Midwest Heart & Vasc Spec
Overland Park, Kansas, 66211
Suncoast Clinical Research, Inc.
Palm Harbor, Florida, 34684
Desert Oasis Hlthcr Med Group
Palm Springs, California, 92262
A&R Research Group, LLC
Pembroke Pines, Florida, 33024
McLaren Northern MI Hosp
Petoskey, Michigan, 49770
Aria Endocrine Metabolic Assoc
Philadelphia, Pennsylvania, 19114
Parkside Family Medicine
Philadelphia, Pennsylvania, 19144
Hanson Clinical Research Center
Port Charlotte, Florida, 33952
Peace River Cardiovascular Center
Port Charlotte, Florida, 33952
CV Research of Knoxville
Powell, Tennessee, 37849
Virginia Commonwealth University Health System
Richmond, Virginia, 23298
Mattoo & Bhat M.A.
Ridgewood, New York, 11385
Riverside Nephrology Physicians
Riverside, California, 92504
Carlos Arauz-Pacheco Md, Pa
Rockwall, Texas, 75032
Endo Res Solutions Inc
Roswell, Georgia, 30076
Northeast Research Institute
Saint Augustine, Florida, 32080
East Coast Institute for Research LLC_St. Augustine
Saint Augustine, Florida, 32086
St Johns Center for Clin. Res
Saint Augustine, Florida, 32086
VA Medical Center_Salem
Salem, Virginia, 24153-6404
University of Utah School of Medicine
Salt Lake City, Utah, 84108
Clinical Advancement Center
San Antonio, Texas, 78212
Sun Research Institute
San Antonio, Texas, 78215
Briggs Clinical Research, LLC
San Antonio, Texas, 78224
University Hospital
San Antonio, Texas, 78229
VIP Trials
San Antonio, Texas, 78230
NE Clin Res of San Antonio
San Antonio, Texas, 78233
N America Res Inst - San Dimas
San Dimas, California, 91773
Javara Privia Grp Gulf Cst LLC
San Marcos, Texas, 78666
Saratoga Clinical Research
Saratoga Springs, New York, 12866
Javara Inc._Winston Salem
Savannah, Georgia, 31406
Unity Health-Searcy Medical Center
Searcy, Arkansas, 72143
Grace Research, LLC_Shreveport
Shreveport, Louisiana, 71105
Endeavor Health
Skokie, Illinois, 60077
Louisiana Heart Center_Slidell
Slidell, Louisiana, 70458
Spartanburg Medical Research
Spartanburg, South Carolina, 29303
Providence Medical Research Center
Spokane, Washington, 99204
Central Illinois Diabetes and Clinical Research
Springfield, Illinois, 62711
Gateway CV Research Cntr Inc.
St Louis, Missouri, 63128
St Louis Heart & Vascular, P.C.
St Louis, Missouri, 63136
Simcare Medical Research, LLC
Sugar Land, Texas, 77478
DaVita Clinical Research - New York
The Bronx, New York, 10461
Cotton O'Neil Diab & Endo Ctr
Topeka, Kansas, 66606
Lundquist Inst-Biomed Innovtn
Torrance, California, 90502
Velocity Clin. Res Valparaiso
Valparaiso, Indiana, 46383
Hillcrest Family Health Center
Waco, Texas, 76708
George Washington Uni Med
Washington D.C., District of Columbia, 20037
Clin Invest Spec, Inc
Wauconda, Illinois, 60084
Aspirus Research Institute
Wausau, Wisconsin, 54401
VA-Connecticut (VACHS)
West Haven, Connecticut, 06516
Southgate Medical Group, LLP
West Seneca, New York, 14224
Great Lakes Medical Research
Westfield, New York, 14787
Marshfield Clinic
Weston, Wisconsin, 54476
Selma Medical Associates
Winchester, Virginia, 22601-3834
Japan100 sites
NIPPON MEDICAL SCHOOL HOSPITAL_Cardiovascular medicine
Bunkyo-ku, Tokyo, 113-8603
The Univ. of Tokyo Hp., Dept. of Cardiovascular Medicine
Bunkyo-ku, Tokyo, 113-8655
Akaicho Clinic
Chiba-shi, Chiba, 260-0804
Fukuokaken Saiseikai Futsukaichi Hospital_Cardiovascular Medicine
Chikushino-shi, Fukuoka, 818-8516
University of Yamanashi Hospital_Cardiology
Chuo-city, Yamanashi, 409-3898
National Hospital Organization Kyushu Medical Center_Nephrology
Fukuoka, 810-8563
Saiseikai Fukuoka General Hospital
Fukuoka-shi, Fukuoka, 810-0001
Fukuoka University Hospital_Cardiology
Fukuoka-shi, Fukuoka, 814-0133
National Hospital Organization Hamada Medical Center_Cardiology
Hamada-shi, Shimane, 697-8511
JA Shizuoka Kohseiren Enshu Hospital_ cardiology
Hamamatsu-shi, Shizuoka, 430-0929
Naka Kinen Clinic_Internal medicine
Ibaraki, 311-0113
Naka Kinen Clinic
Ibaraki, 311-0113
National Hospital Organization Mito Medical Center_Cardiovascular medicine
Ibaraki, 311-3193
Nishiyamado Keiwa Hospital_Internal Medicine
Ibaraki, 331-0133
Nishiyamado Keiwa Hospital
Ibaraki, 331-0133
Kishiwada Tokushukai Hospital_Cardiology
Kishiwada, Osaka, 596-0042
North Alps Medical Center Azumi Hospital_Cardiology
Kita-azumi-gun, Nagano, 399-8695
Steel Memorial Yawata Hospital_Cardiology
Kitakyushu-shi, Fukuoka, 805-8508
Kokura Memorial Hospital_Cardiology
Kitakyushu-shi,Fukuoka, 802-8555
National Hospital Organization Fukuokahigashi Medical Center_Nephrology
Koga-shi, Fukuoka, 811-3195
National Hospital Organization Fukuokahigashi Medical Center
Koga-shi, Fukuoka, 811-3195
Seino Internal Medicine Clinic
Koriyama-shi, Fukushima, Japan, 963-8851
Seino Internal Medicine Clinic_Internal medicine
Koriyama-shi, Fukushima, Fukushima, Japan, 963-8851
Jinnouchi Hospital_Internal Medicine
Kumamoto, Kumamoto, Japan, 862-0976
Kumamoto University Hospital, Cardiovascular Medicine
Kumamoto-shi, Kumamoto, 860-8556
NHO Kure Medical Center and Chugoku Cancer Center_Cardiology
Kure-shi, Hiroshima, 737-0023
Kyoto Okamoto Memorial Hospital_Cardiology
Kusegun, Kyoto, 613-0034
Kyoto Okamoto Memorial Hospital
Kusegun, Kyoto, 613-0034
Rakuwakai Otowa Hospital_Cardiology
Kyoto-shi, Kyoto, 607-8062
Rakuwakai Otowa Hospital
Kyoto-shi, Kyoto, 607-8062
National Hospital Organization Kyoto Medical Center_Cardiology
Kyoto-shi, Kyoto, 612-8555
Ijinkai Takeda General Hospital, Cardiovascular Medicine
Kyoto-shi,Kyoto, 601-1495
Maebashi Red Cross Hospital_Cardiology
Maebashi-shi, Gunma, 371-0811
Maebashi Red Cross Hospital
Maebashi-shi, Gunma, 371-0811
Matsubara Tokushukai Hospital_Neurosurgery
Matsubara-shi, Osaka, 580-0032
Chiba-Nishi General Hospital, Cardiology
Matsudo-shi, 270-2251
Chiba-Nishi General Hospital, Cardiology
Matsudo-shi, Chiba, 270-2251
Shinshu University Hospital__Department of Cardiology
Matsumoto-shi, Nagano, 390-8621
Shinshu University Hospital_Matsumoto-shi, Nagano
Matsumoto-shi, Nagano, 390-8621
Mishuku Hospital_Cardiology
Meguro-ku, Tokyo, 153-0051
Tokyo Saiseikai Central Hospital
Minato-ku, Tokyo, 108-0073
Hayama Heart Center_Cardiology
Miura-gun, Kanagawa, 240-0116
Hayama Heart Center
Miura-gun, Kanagawa, 240-0116
Miyakonojo Medical Association Hospital_Cardiology
Miyakonojo-shi, Miyazaki, 885-0002
Miyakonojo Medical Association Hospital
Miyakonojo-shi, Miyazaki, 885-0002
Miyazaki Medical Association Hospital_Cardiology
Miyazaki, Miyazaki, 880-2102
Iwate Prefectural Central Hospital_Cardiology
Morioka-shi, Iwate, 020-0066
Iwate Prefectural Central Hospital
Morioka-shi, Iwate, 020-0066
Social Medical Corporation Kojunkai Daido Clinic
Nagoya-shi, Aichi, 457-0818
Nagoya University Hospital_Cardiology
Nagoya-shi, Aichi, 466-8560
Naha City Hospital_Cardiovascular Medicine
Naha-shi, Okinawa, 902-8511
Naha City Hospital
Naha-shi, Okinawa, 902-8511
Nara Prefecture General Medical Center_Nephrology
Nara-shi, Nara, 630-8581
Nara Prefecture General Medical Center
Nara-shi, Nara, 630-8581
Hyogo Prefectual Nishinomiya General Medical Center_Nephrology
Nishinomiya-shi, Hyogo, 663-8241
Oita Medical Center_Cardiology
Oita-shi, Oita, 870-0263
Kawasaki Medical School Hospital_Nephrology
Okayama, 701-0192
Omihachiman Community Medical Center_Cardiovascular Medicine
Omihachiman-shi, Siga, 523-0082
Omihachiman Community Medical Center_Omihachiman-shi, Siga
Omihachiman-shi, Siga, 523-0082
Saiseikai Suita Hospital_Cardiovascular Medicine
Osaka, 564-0013
Takatsuki Red Cross Hospital_Diabetes and Endocrine Div.
Osaka, 569-1045
Takatsuki Red Cross Hospital
Osaka, 569-1045
Yao Tokushukai General Hospital_Cardiovascular division
Osaka, 581-0011
Sakurabashi Watanabe Advanced Healthcare Hospital
Osaka-city, Osaka, 530-0005
Yodogawa Christian Hospital_Cardiovascular medicine
Osaka-shi, Osaka, 533-0024
Osaka City General Hospital_Cardiology
Osaka-shi, Osaka, 534-0021
Kitada Clinic
Osaka-shi, Osaka, 538-0044
Social Corporation Keigakukai Minami Osaka Hospital_Cardiology
Osaka-shi,Osaka, 559-0012
Ota Memorial Hospital_Cardiology
Ota-shi, Gunma, 373-8585
Ota Memorial Hospital
Ota-shi, Gunma, 373-8585
Kitasato University Hospital_Cardiovascular Medicine
Sagamihara-shi, Kanagawa, 252-0375
Kitasato University Hospital_Sagamihara-shi, Kanagawa
Sagamihara-shi, Kanagawa, 252-0375
National Hospital Organization Sagamihara National Hospital_Cardiology
Sagamihara-shi, Kanagawa, 252-0392
National Hospital Organization Sagamihara National Hospital
Sagamihara-shi, Kanagawa, 252-0392
Sanai Hospital_Cardiology
Saitama-shi, Saitama, 338-0837
Sanai Hospital
Saitama-shi, Saitama, 338-0837
Hanaoka Seishu Memorial Hosp._Cardiovascular Medicine
Sapporo-shi, Hokkaido, 062-0003
Tohoku University Hospital, Cardiovascular
Sendai-shi, Miyagi, 980-8574
Sendai Cardiovascular Center_Cardiology
Sendai-shi, Miyagi, 981-3133
Shinden Higashi Clinic_Internal medicine
Sendai-shi, Miyagi, 983-0039
Shinden Higashi Clinic
Sendai-shi, Miyagi, 983-0039
JA Shizuoka Kohseiren Enshu Hospital_Internal Medicine
Shizuoka, 430-0929
Saiseikai Suita Hospital_Suita-shi, Osaka
Suita-shi, Osaka, 564-0013
Osaka Saiseikai Senri Hospital_Cardiology
Suita-shi, Osaka, 565-0862
Osaka Saiseikai Senri Hospital
Suita-shi, Osaka, 565-0862
National Hospital Organization Disaster Medical Center_Nephrology
Tachikawa-shi, Tokyo, 190-0014
Takamatsu Red Cross Hospital_Cardiovascular Medicine
Takamatsu-shi, Kagawa, 760-0017
Kagawa Prefectural Central Hospital_Cardiovascular Medicine
Takamatsu-shi, Kagawa, 760-8557
Minamino Cardiovascular Hospital_Cardiovascular medicine
Tokyo, 192-0918
Saiseikai tondabayashi Hospital_Cardiology
Tondabayashi-shi, Osaka, 584-0082
Tsukuba Medical Center Hospital_Department of Cardiology
Tsukuba-shi, Ibaraki, 305-8558
Uwajima City Hospital_ Cardiology
Uwajima-shi, Ehime, 798-8510
Uwajima City Hospital_Cardiology
Uwajima-shi, Ehime, 798-8510
Japanese Red Cross Wakayama Medical Center_Diabetology and Endocrinology
Wakayama, 640-8558
National Hospital Organization Saitama Hospital_Cardiology
Wako-shi, Saitama, 351-0102
National Hospital Organization Saitama Hospital
Wako-shi, Saitama, 351-0102
Saiseikai Yokohamashi Nanbu Hospital_Cardiology
Yokohama-shi, Kanagawa, 234-0054
Yokohama City University Hospital
Yokohama-shi, Kanagawa, 236-0004
Sanyudo Hospital_Cardiology
Yonezawa-shi, Yamagata, 992-0033
Sanyudo Hospital
Yonezawa-shi, Yamagata, 992-0033
China81 sites
Beijing Anzhen Hospital, Capital Medical University
Beijing, Beijing Municipality, 100029
Peking University First Hospital-Cardiology
Beijing, Beijing Municipality, 100034
Peking University First Hospital
Beijing, Beijing Municipality, 100034
Chinese Academy of Medical Sciences Fuwai Hospital
Beijing, Beijing Municipality, 100037
Xuanwu Hospital Capital Medical University-Cardiology
Beijing, Beijing Municipality, 100053
Peking University Third Hospital-Cardiology
Beijing, Beijing Municipality, 100191
Beijing Hospital-Nephrology
Beijing, Beijing Municipality, 100730
Chinese People's Liberation Army General Hospital-Nephrology
Beijing, Beijing Municipality, 100853
Chinses PLA General Hospital-Nephrology
Beijing, Beijing Municipality, 100853
Xuanwu Hospital Capital Medical University-Cardiology
Beijing, 100053
China-Japan Union Hospital of Jilin University-Cardiology
Changchun, Jilin, 130033
China-Japan Union Hospital of Jilin University
Changchun, Jilin, 130033
The Second Hospital of Jilin University_Changchun
Changchun, Jilin, 130033
The Second Norman Bethune Hospital of Jilin University-Nephrology
Changchun, Jilin, 130033
The First People's Hospital of Changde City -Internal Medicine-Cardiovascular
Changde, Hunan, 415003
The First People's Hospital of Changde City -Internal Medicine-Cardiovascular
Changde, 415003
Changzhou No.2 People's Hospital
Changzhou, Jiangsu, 213003
The First People's Hospital of Changzhou
Changzhou, Jiangsu, 213004
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital; Affiliated Hospital of UESTC-Nephrology
Chengdu, Sichuan, 610071
Sichuan Provincial People's Hospital- Nephrology
Chengdu, 610071
The Second Affiliated Hospital of Chongqing Medical University-Cardiology
Chongqing, Chongqing Municipality, 402260
The First Affiliated Hospital of Dalian Medical University-Nephrology
Dalian, Liaoning, 116011
The First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, 116011
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital) -Cardiology
Dalian, Liaoning, 116033
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital) -Nephrology
Dalian, Liaoning, 116033
Fu Yang People's Hospital-Nephrology
Fuyang, Anhui, 236000
Zhujiang Hospital of Southern Medical University-Cardiology
Guangzhou, Guangdong, 510280
The First Affiliated Hospital, Zhejiang University School of Medicine-Cardiology
Hangzhou, Zhejiang, 310003
Zhejiang Provincial People's Hospital-Cardiology Department
Hangzhou, Zhejiang, 310014
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, 310014
The First Affiliated Hospital, Zhejiang University School of Medicine-Cardiology
Hangzhou, 310003
The Second Hospital of Anhui Medical University
Hefei, Anhui, 230601
The Second People's Hospital of Huai'an-Nephrology
Huai'an, Jiangsu, 223022
Huizhou Central People's Hospital_Internal Medicine-Cardiovascular Dept
Huizhou, Guangdong, 516001
Huizhou Central People's Hospital_Internal Medicine-Cardiovascular Dept
Huizhou, 516001
Jinan Central Hospital-Cardiovascular
Jinan, Shandong, 250013
The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)-Cardiology
Jinan, Shandong, 250013
The Second Hospital of Shandong University
Jinan, Shandong, 250033
Jinan Central Hospital Affiliated to Shandong University (Cardiovascular Dept)
Jinan, 250013
The Second Hospital of Shandong University
Jinan, 250033
The First Affiliated Hospital of Jinzhou Medical University-Cardiology
Jinzhou, Liaoning, 121012
The Second Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, 650033
Lanzhou University Second Hospital_Internal Medicine-Cardiovascular Dept
Lanzhou, Gansu, 730030
The Second Hospital & Clinical Medical School, Lanzhou University-Internal Medicine & Cardiovascular
Lanzhou, Gansu, 730030
Linfen Central Hospital-Cardiology
Linfen, Shanxi, 041099
The First Affiliated Hospital of Henan University of Science and Technology-Nephrology
Luoyang, Henan, 471003
Jiangxi Provincial People's Hospital-Cardiology
Nanchang, Jiangxi, 330006
The First Affiliated Hospital of Nanchang University-Nephrology
Nanchang, Jiangxi, 330006
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006
Zhongda Hospital Southeast University
Nanjing, Jiangsu, 210009
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, 210011
The People's Hospital of Guangxi Zhuang Autonomous Region-Nephrology Department
Nanning, Guangxi, 530016
The People's Hospital of Guangxi Zhuang Autonomous Region-Cardiology Department
Nanning, Jiangsu, 530016
Huashan Hospital Fudan University
Shanghai, Shanghai Municipality, 200040
Shanghai General Hospital-Cardiology
Shanghai, Shanghai Municipality, 200080
Xinhua Hospital Affiliated to Shanghai Jiao Tong University-Nephrology
Shanghai, Shanghai Municipality, 200092
Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University-Nephrology
Shanghai, Shanghai Municipality, 200233
Central Hospital of Minhang District, Shanghai-Nephrology
Shanghai, Shanghai Municipality, 201199
The Second Affiliated Hospital of Shantou University Medical College-Nephrology
Shantou, Guangdong, 515065
The Second Affiliated Hospital of Shantou University Medical College-Nephrology
Shantou, 515065
Shengjing Hospital of China Medical University-Cardiology
Shenyang, Liaoning, 110136
Shengjing Hospital of China Medical University
Shenyang, 110136
Shenzhen People's Hospital
Shenzhen, Guangdong, 518020
The First Affiliated Hospital of Soochow University-Cardiology
Suzhou, Jiangsu, 215006
Tianjin People's Hospital
Tianjin, Tianjin Municipality, 300122
Tianjin 4th Center Hospital
Tianjin, Tianjin Municipality, 300140
Union Hospital Tongji Medical College Huazhong University of Science and Technology - Cardiology
Wuhan, Hubei, 430022
Tongji Hospital, Tongji Medical College of HUST-Nephrology
Wuhan, Hubei, 430030
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology-Cardiology
Wuhan, Hubei, 430030
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology-Nephrology
Wuhan, Hubei, 430030
Renmin Hospital of Wuhan University-Cardiology
Wuhan, Hubei, 430060
Renmin Hospital of Wuhan University
Wuhan, Hubei, 430060
The First Affiliated Hospital of Xi'an JiaoTong University-Cardiovascular
Xi'an, Shaanxi, 710061
Zhongshan Hospital Xiamen University-Nephrology
Xiamen, Fujian, 361004
Xingtai People's Hospital-Nephrology
Xingtai, Hebei, 054031
The Third Affiliated Hospital of Xinxiang Medical University-Cardiology
Xinxiang, Henan, 453000
The Affiliated Hospital of Xuzhou Medical University-Cardiology
Xuzhou, Jiangsu, 221002
The Affiliated Hospital Of Xuzhou Medical University
Xuzhou, Jiangsu, 221002
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052
The Affiliated Hospital of Jiangsu University-Nephrology
Zhenjiang, Jiangsu, 212001
The Affiliated Hospital of Jiangsu University
Zhenjiang, Jiangsu, 212001
India50 sites
Apollo CHSF Heart Institute
Ahmedabad, Gujarat, 380059
Manipal Hospital, Old Airport Road, Bengaluru
Bangalore, Karnataka, 560017
Lifecare Hospital and Research Centre
Bangalore, Karnataka, 560092
KLES & Prabhakar Kore Hospital and Research Centre
Belagavi, Karnatka, 590010
Sri Jayadeva Institute of Cardiovascular Sciences & Research
Bengaluru, Karnataka, 560069
Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh
Chandigarh, 160012
Apollo Hospitals Education & Research Foundation
Chennai, Tamil Nadu, 600006
Kamalnayan Bajaj Hospital
Chhatrapati Sambhajinagar, Maharashtra, 431005
Kamalnayan Bajaj Hospital
Chhatrapati Sambhajinagar, Maharashtra, 431010
Lalitha PVS Institute of Medical Sciences
Guntur, Andhra Pradesh, 522001
Vedanta Hospitals
Guntur, Andhra Pradesh, 522001
NIZAM'S Institute of Medical Sciences
Hyderabad, Andhra Pradesh, 500082
Osmania General Hospital_Hyderabad
Hyderabad, Telangana, 500012
Osmania General Hospital
Hyderabad, Telangana, 500012
Guru Nanak CARE Hospitals
Hyderabad, Telangana, 500020
Apollo Hospital Jubilee Hills, Hyderabad
Hyderabad, Telangana, 500033
Osmania General Hospital
Hyderbad, Telangana, 500 012
Eternal Heart Care Centre
Jaipur, 302017
Lisie Hospital
Kochi, Kerala, 682018
Calicut Medical College
Kozhikode, Kerala, 673008
Gandhi Memorial Hospital- King George's Medical University
Lucknow, Uttar Pradesh, 226003
Medanta Lucknow Hospital
Lucknow, Uttar Pradesh, 226030
Dayanand Medical College & Hospital
Ludhiana, Punjab, 141001
Omega Hospital (P) Limited
Mangalore, Karnataka, 575002
Kasturba Medical College and Hospital, Manipal
Manipal, Karnataka, 576104
Kasturba Medical College and Hospital
Manipal, Karnataka, 576104
Seth GS medical college and KEM Hospital
Mumbai, Maharashtra, 400012
Government Medical College and Super Speciality Hospital, Nagpur
Nagpur, Maharashtra, 440009
Arneja Heart & Multispeciality Hospital
Nagpur, Maharashtra, 440010
Shri Krishna Hrudayalaya & Critical Care Centre
Nagpur, Maharashtra, 440012
Chopda Medicare and Research Centre Pvt. Ltd.
Nashik, Maharashtra, 422005
Vijan Hospital & Research Centre
Nashik, Maharashtra, 422005
VMMC & Safdarjung Hospital
New Dehli, New Delhi, 110029
G B Pant Institute of Postgraduate Medical Education and Research
New Delhi, National Capital Territory of Delhi, 110002
Fortis Escorts Heart Institute, New Delhi
New Delhi, National Capital Territory of Delhi, 110025
Batra Hospital and Medical Research Center
New Delhi, National Capital Territory of Delhi, 110062
G B Pant Institute of Postgraduate Medical Education and Res
New Delhi, 110002
Lok Nayak Hospital
New Delhi, 110002
Max Super Speciality Hospital, Saket
New Delhi, 110017
Max Super Speciality Hospital_New Delhi
New Delhi, 110017
Fortis Escort Health Institute
New Delhi, 110025
Sir Ganga Ram Hospital
New Delhi, 110060
Lakshmi Hospital
Palakkad, 678013
B J Goverment Medical College and Sassoon General Hospital
Pune, Maharashtra, 411001
Grant Medical Foundation
Pune, Maharashtra, 411001
Shri B. D. Mehta Mahavir Heart Institute
Surat, Gujarat, 395001
Unicare heart institute and research centre
Surat, Gujarat, 395001
BAPS Pramukh Swami Hospital
Surat, Gujarat, 395009
Government Medical College Trivandrum
Trivandrum, Kerala, 695011
Sunrise Hospital
Vijayawada, Andhra Pradesh, 520002
Germany36 sites
Uniklinik Aachen - Med. Klinik I
Aachen, 52074
Universitaetsklinikum Aachen AöR
Aachen, 52074
Kardiologische Praxis, Bad Homburg
Bad Homburg, 61348
Charité - Campus Benjamin Franklin - Klinik für Nephrologie und Internistische Intensivmedizin
Berlin, 12203
Sana Kliniken Oberfranken Coburg GmbH - II. Med. Klinik, Kardiologie
Coburg, Thuringia, 96450
Praxis Dr.med. Frank Menzel
Dessau, 06846
Facharztzentrum Dresden Betriebsgesellschaft mbH
Dresden, 01099
Cardiologicum Dresden und Pirna - MVZ "Am Felsenkeller" (Dresden)
Dresden, 01277
Kreutzmann
Dresden, 01277
Herzzentrum Dresden GmbH Universitaetsklinik
Dresden, 01307
Uniklinik TU Dresden - Herzzentrum Dresden GmbH
Dresden, 01307
DaVita Clinical Research Deutschland GmbH
Düsseldorf, 40210
Zentrum für klinische Studien Südbrandenburg GmbH
Elsterwerda, 04910
InnoDiab Forschung GmbH
Essen, 45136
Zentrum für klinische Forschung, Dr. med. Lüdemann
Falkensee, 14612
MVZ CCB Frankfurt Und Main-Taunus GbR
Frankfurt, 60389
Nephrologie Universitätsklinikum Frankfurt
Frankfurt, 60590
Uniklinik FFM - Nephrologie
Frankfurt, 60590
Studienzentrum ClinPhenomics
Frankfurt, 60596
Universitätsklinikum Freiburg - Medical Center
Freiburg im Breisgau, Baden-Wurttemberg, 79106
Nierenzentrum Freiburg
Freiburg im Breisgau, 79100
Universitätsklinikum Halle - Innere Medizin II
Halle, 06120
St. Josefskrankenhaus Heidelberg - Diabeteszentrum
Heidelberg, 69115
Universität des Saarlandes - Innere Med. III
Homburg, 66421
Universität des Saarlandes - Innere Med. IV
Homburg Saar, 66421
Uniklinik Jena - Kardiologie
Jena, 07747
University Hospital Jena KöR
Jena, 07747
SRH Klinikum Karlsbad-Langensteinbach GmbH - Innere Medizin
Karlsbad, Baden-Wurttemberg, 76307
Uniklinik Schleswig-Holstein - Medizinischen Klinik I am Campus Lübeck
Lübeck, 23538
Marienhaus Klinikum Mainz GmbH - Innere Medizin I
Mainz, 55131
Universitätsmedizin der JGU Mainz - Kardiologie I
Mainz, 55131
zero PRAXEN Mannheim-Schwetzingerstadt
Mannheim, 68165
RED-Institut für medizinische Forschung und Fortbildung GmbH
Oldenburg in Holstein, Holstein, 23758
Praxis Reichelsheim
Reichelsheim, 61203
Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann
Witten, 58455
Kahrmann
Witten, 58455
United Kingdom36 sites
The Crouch Oak Family Practice
Addlestone, Surrey, KT15 2BH
Barnet Hospital - Cardiology Department
Barnet, EN5 3DJ
Sandwell General Hospital
Birmingham, B71 4HJ
Blackpool Victoria Hospital
Blackpool, Lancashire, FY3 8NR
Royal Bournemouth Hospital - Cardiology
Bournemouth, Dorset, BH7 7DW
Bradford Royal Infirmary
Bradford, BD9 6RJ
The Health Centre
Bradford on Avon, BA15 1DQ
Southmead Hospital
Bristol, BS10 5NB
Addenbrooke's Hospital - Cambridge Dialysis Centre
Cambridge, CB5 8PD
St. Richard's Hospital_Cardiology
Chichester, West Sussex, PO19 6SE
Lakeside Healthcare Research & Innovation Unit
Corby, Northamptonshire, NN17 2UR
Dorset County Hospital
Dorchester, Dorset, DT1 2JY
The Adam Practice
Dorset, BH16 5PW
Carmel Medical Practice
Durham, DL3 8SQ
Royal Devon and Exeter Hospital
Exeter, EX2 5DW
Wycombe General Hospital
High Wycombe, HP11 2TT
Cardiology
Leicester, LE3 9QP
Leicester General Hospital
Leicester, LE5 4PW
Lincoln County Hospital
Lincoln, LN2 5QY
Liverpool Heart & Chest Hospital
Liverpool, L14 3PE
Aintree University Hospital
Liverpool, L9 7AL
University Hospital Aintree
Liverpool, L9 7AL
William Harvey Clinical Research Centre
London, EC1M 6BQ
William Harvey Research Institute
London, EC1M 6BQ
King's College Hospital
London, SE5 9RS
Freeman Hospital, Newcastle
Newcastle upon Tyne, NE7 7DN
John Radcliffe Hospital
Oxford, OX3 9DU
Pickering Medical Practice
Pickering, North Yorkshire, YO18 8BL
Panthera Biopartners Preston
Preston, PR2 9RB
Sherbourne Medical Centre
Royal Leamington Spa, CV32 4RA
Ashfields Primary Care Centre
Sandbach, Cheshire, CW11 1EQ
Lister Hospital
Stevenage, SG1 4AB
University of North Tees Hospital
Stockton-on-Tees, TS19 8PE
Musgrove Park Hospital
Taunton, TA1 5DA
Torbay Hospital - Cardiology
Torquay, TQ2 7AA
Albany House Medical Centre
Wellingborough, NN8 4RW
Greece35 sites
Alexandroupoli University General Hospital
Alexandroupoli, 68100
University Hospital of Athens ATTIKON
Athens, Attica, 12462
"Laiko" General Hospital of Athens
Athens, 11527
Hippokration Hospital
Athens, 11527
Thoracic General Hospital Of Athens I Sotiria - Cardiology Department
Athens, 11527
Alexandra General Hospital, Therapeutic Clinic
Athens, 11528
Konstantopouleio G.H. of Athens, "Agia Olga"
Athens, 14233
"Hygeia" General Hospital of Athens
Athens, 15123
Iatriko Athinon (Athens Medical Canter)
Athens, 15125
Iatriko Athinon 'Palaiou Falirou'
Athens, 17562
Konstantopouleio G.H. of Athens, "Agia Olga"
Athens, GR-14233
"Hygeia" General Hospital of Athens
Athens, GR-15123
Iatriko Athinon 'Palaiou Falirou'
Athens, GR-17562
General Hospital of Chios "Skilitsio" - Cardiology Clinic
Chios, 82100
General Hospital of Chios "Skilitsio"
Chios, GR82100
University Hospital of Athens ATTIKON
Haidari-Athens, Attica, GR-12462
Periphery University Hospital of Heraklion
Heraklion, 71500
University General Hospital Of Heraklion
Heraklion, 71500
University General Hospital of Ioannina,Internal Medicine
Ioannina, 45500
Kat Attica General Hospital - Cardiology Department
Kifissia, 14561
KAT General Hospital of Attica
Kifissia, GR-14561
General Hospital of Lamia
Lamia, 35100
Univ Gen Hospital Larisa, Cardiology Medicine Clinic
Larissa, 41110
Univ Gen Hospital Larisa, Cardiology Medicine Clinic
Larissa, GR-41110
Iatriko Athinon (Athens Medical Canter)
Pylea, Thessaloniki, 57001
General University Hospital of Patras,Nephrology clinic
Rio, Patra, 26504
"AHEPA" University General Hospital of Thessaloniki
Thessaloniki, 54636
"AHEPA" University Hospital of Thessaloniki
Thessaloniki, 54636
General Hospital of Thessaloniki "Ippokrateio"
Thessaloniki, 54642
General Hospital of Thessaloniki 'Ippokrateio' Dialysis Unit
Thessaloniki, 54642
General Hospital of Thessaloniki 'Agios Pavlos' - Nephrology Clinic
Thessaloniki, 55134
"Thermi" Private Hosital
Thessaloniki, 57001
Iatriko Athinon (Athens Medical Canter)
Thessaloniki, 57001
Gen Hospital of Thessaloniki G.Papanikolaou,Cardiology Dpt
Thessaloniki, 57010
"Thermi" Private Hosital
Thessaloniki, GR-57001
Poland35 sites
Kresmed Sp. z o. o.
Bialystok, Podlaskie Voivodeship, 15-481
Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio
Bialystok, Podlaskie Voivodeship, 15-540
Malopolskie Centrum Sercowo-Naczyniowe
Chrzanów, Lesser Poland Voivodeship, 32-500
Centrum Kliniczno Badawcze
Elblag, 82-300
Centrum Kliniczno-Badawcze J. Brzezicki, B. Górnikiewicz-Brzezicka Lekarze Spółka Partnerska
Elblag, 82-300
Ind. Spec. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman
Gdynia, Pomeranian Voivodeship, 81-157
Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski
Gorzów Wielkopolski, Lubusz Voivodeship, 66-400
Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II
Grodzisk Mazowiecki, 05-825
Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET
Krakow, Lesser Poland Voivodeship, 31-261
Specjalistyczna Praktyka Lekarska L. Bryniarski
Krakow, 30-082
Krakowski Szpital Specjalistyczny im. Jana Pawla II
Krakow, 31-202
Praktyka Lekarska Mateusz Sidor
Krakow, 31-261
Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A.
Lodz, 90-338
Centrum Terapii Wspolczesnej
Lodz, 90-338
Salve Medica
Lodz, 91-211
Instytut Centrum Zdrowia Matki Polki
Lodz, 93-338
Uniwersytecki Szpital Kliniczny nr 2 Uniwersytetu Medycznego w Lodzi
Lodz, Łódź Voivodeship, 90-549
NZOZ "CenterMed Lublin" Sp. z o.o.
Lublin, Lublin Voivodeship, 20-044
Specjalistyczna Praktyka Lekarska w Ogrodzieńcu
Ogrodzieniec, 42-440
ETG Poniatowa
Poniatowa, Lublin Voivodeship, 24-320
Uniwersytecki Szpital Kliniczny W Poznaniu
Poznan, 61-848
Velocity Nova Sp. z o.o.
Puławy, 24-100
Aka-Med Centrum
Ruda Śląska, Silesian Voivodeship, 41-710
Poradnia Aka-Med Centrum Sp. z o.o.
Ruda Śląska, Silesian Voivodeship, 41-710
CENTRUM MEDYCZNE VITA Praktyka Kardiologiczna
Szczecin, 70-341
Polsko - Amerykanskie Kliniki Serca X Oddzial Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji w Tychach
Tychy, 43-100
NBR Polska Tomasz Klodawski
Warsaw, 00-710
Narodowy Instytut Kardiologii Klin. Kard. i Ang.
Warsaw, 04-628
Narodowy Instytut Kardiologii Klin. Kard. i Transp.
Warsaw, 04-628
Szpital Powiatowy Im. Hrabiego Stanislawa Lubienskiego Samodzielny Publiczny Zakład Opieki Zdrowotnej W Wegrowie
Węgrów, 07-100
Kardio Life - Tomasz Borkowski
Włocławek, Kuyavian-Pomeranian Voivodeship, 87-800
4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
Wroclaw, Lower Silesian Voivodeship, 50-981
Zdrowie S.C. Agnieszka I Donald Drozdz
Wroclaw, Lower Silesian Voivodeship, 51-134
Centrum Badan Klinicznych
Wroclaw, 51-162
Velocity Nova Sp. z o.o. Velocity Zamosc
Zamość, 22-400
Bulgaria31 sites
MC Diamedical - 2013 OOD, Dimitrovgrad
Dimitrovgrad, 6400
Medical Centre Diamedical-2013
Dimitrovgrad, 6400
'Medical center Medi city 21' OOD
Kyustendil, 2500
Medical center Medi City 21 OOD
Kyustendil, 2500
MC Hera EOOD - Montana
Montana, 3400
SHATC Sveti Georgi - Pernik OOD
Pernik, 2300
"Medical center Medconsult Pleven" OOD
Pleven, 5800
Medical center Medconsult Pleven OOD
Pleven, 5800
MHAT Heart and Brain EAD - Pleven, Cardiology
Pleven, 5804
MHAT Heart and Brain
Pleven, 5804
UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology
Plovdiv, 4002
'MHAT Hadzhi Dimitar' OOD
Sliven, 8800
MHAT Hadzhi Dimitar OOD
Sliven, 8800
Mhat "Nch"
Sofia, 1309
MHAT National Cardiology Hospital EAD
Sofia, 1309
"Acibadem City Clinic UMHAT" EOOD, Sofia, Cardiology clinic
Sofia, 1407
Acibadem City Clinic UMHAT EOOD, Cardiology
Sofia, 1415
DCC Aleksandrovska EOOD
Sofia, 1431
UMHAT "Sveti Ivan Rilski"
Sofia, 1431
UMHAT Sveti Ivan Rilski EAD, Nephrology
Sofia, 1431
MC Hera EOOD - Sofia
Sofia, 1510
Medical center ISUL - Tsaritsa Yoanna EOOD
Sofia, 1527
"UMHAT "Sveta Anna" Sofia" AD, Clinic of Cardiology
Sofia, 1750
"UMHAT "Sveta Anna" Sofia"
Sofia, 1750
MHAT Sveta Anna Sofia AD, Clinic of Cardiology
Sofia, 1750
UMHAT Sveta Anna Sofia AD, Department of Endocrinology
Sofia, 1750
Prevencia - 2000 - MCOC OOD
Stara Zagora, 6000
Medical Center "Nov Rehabilitatsionen center" EOOD
Stara Zagora, 6001
Medical Center Nov Rehabilitatsionen center EOOD
Stara Zagora, 6001
UMHAT Sveta Marina EAD, Second Clinic of Cardiology
Varna, 9010
MC Berbatov EOOD, Cherni Drin
Yambol, 8600
Romania31 sites
Cabinet Medical de Cardiologie Dr. Calin Pop
Baia Mare, 430222
Spitalul Județean de Urgență Brăila
Brăila, 810325
S.C. Centrul Medical Unirea S.R.L.
Brasov, 500091
Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed
Brasov, 500283
Institutul Clinic Fundeni
Bucharest, Bucharest, 022328
Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila
Bucharest, Bucurestii, 020475
Hightech Medical Services S.R.L.
Bucharest, 011053
Spitalul Universitar de Urgență Elias
Bucharest, 011461
Lotus Med SRL
Bucharest, 012292
Centrul Medical Emerald
Bucharest, 014146
Donna Medplus S.R.L.
Bucharest, 020339
Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila
Bucharest, 020475
Davius Clinicmed Srl
Bucharest, 021875
Spitalul Clinic de Urgenta "Sf. Ioan" Bucuresti
Bucharest, 042122
Spitalul Universitar de Urgenta Bucuresti
Bucharest, 050098
Mat Cord Biomedica S.R.L.
Buzău, 120133
Clinic of Diabetes Cluj
Cluj-Napoca, Cluj, 400006
Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta
Constanța, 900591
Neurocord Medical SRL
Craiova, 200383
Cardiomed SRL
Craiova, 200513
SC Diamed Obesity SRL
Galati, 800291
Institutul de Boli Cardiovasculare "Prof. Dr. George I.M. Georgescu"
Iași, 700503
SC Consultmed SRL
Iași, 700547
SC Cardiomed SRL
Iași, 700732
Spitalul Clinic Judetean De Urgenta Bihor
Oradea, 410469
Bella Praxis S.R.L.
Paşcani, 705200
Sc Sal Med Srl
Piteşti, 110424
Spitalul Clinic Judetean de Urgenta Targu Mures
Târgu Mureş, 540136
CMI Dr. Cristian Podoleanu
Târgu Mureş, 540143
Spitalul Clinic Municipal de Urgenta Timisoara
Timișoara, 300254
Institutul de Boli Cardiovasculare Timisoara
Timișoara, 300310
Canada30 sites
LMC Diabetes & Endocrinology (Barrie)
Barrie, Ontario, L4N 7L3
LMC ClinRsrh Inc.Brampton
Brampton, Ontario, L6S 0C6
Viacar Recherche Clinique Inc.
Brossard, Quebec, J4Z-2K9
LMC Clin Res Inc. Calgary
Calgary, Alberta, T2H 2G4
C-Health Partners
Calgary, Alberta, T2V 4J2
Cambridge Cardiac Care Centre
Cambridge, Ontario, N1R 6V6
LMC Clin Res Inc. Thornhill
Concord, Ontario, L4K 4M2
Centricity Research Etobicoke Endocrinology
Etobicoke, Ontario, M9R 4E1
Nova Scotia Hlth Halifax
Halifax, Nova Scotia, B3H 2Y9
Premier Clinical Trial Research Network (PCTRN)
Hamilton, Ontario, L8L 5G4
Ctr de recherche Clinique de Laval
Laval, Quebec, H7T 2P5
Viacar Recherche Clinique Inc.
Longueuil, Quebec, J4H4B9
One Heart Care
Mississauga, Ontario, L4Y 1M3
LMC Research Inc. Ottawa
Nepean, Ontario, K2J 0V2
Partnrs Adv Cardio Eval (PACE)
Newmarket, Ontario, L3Y 2P6
North York Diagn & Cardiac Ctr
North York, Ontario, M6B 3H7
Oakville Cardiovascular Research LP
Oakville, Ontario, L6K 3W7
LMC Clinical Research Inc. Oakville
Oakville, Ontario, L6M 1M1
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2
Recherche Clinique Sigma inc
Québec, G1G 5X1
Institut universitaire de cardiologie
Québec, G1V 4G5
CHU de Quebec-Universite Laval
Québec, G1V4G2
Heart Health Institute Research, Inc.
Scarborough Village, Ontario, M1B 4Z8
Centre de Recherche du CHUS
Sherbrooke, Quebec, J1H 5N4
Synergy Wellness Clinic
Sherwood Park, Alberta, T8H 0N2
Centre de santé et de services
Terrebonne, Quebec, J6V 2H2
LMC Endo Centres Ltd.(Bayview)
Toronto, Ontario, M4G 3E8
Diabetes Heart Research Centre
Toronto, Ontario, M6G 1M2
BC Diabetes Canada
Vancouver, British Columbia, V5Y 3W2
Clinical Research Solutions Inc.
Waterloo, Ontario, N2T 0C1
Turkey (Türkiye)27 sites
Afyonkarahisar Health Sciences University
Afyonkarahisar, 03200
Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji
Afyonkarahisar, 03200
Hacettepe Universitesi Tip Fakultesi Nefroloji Bilim Dali
Ankara, 06230
Hacettepe University Medical Faculty_Ankara
Ankara, 06230
Hacettepe Üniversitesi Hastanesi- Kardiyoloji
Ankara, 06230
Hacettepe Üniversitesi Hastanesi- Nefroloji
Ankara, 06230
Ankara Bilkent Şehir Hastanesi-Kardiyoloji
Ankara, 06800
Akdeniz Universitesi Hastanesi Nefroloji Bilim Dali
Antalya, 07058
Akdeniz Üniversitesi Hastanesi-Nefroloji
Antalya, 07058
Aydın Adnan Menderes Üniversitesi Hastanesi- Nefroloji
Aydin, 09100
Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji
Edirne, 22030
Eskisehir Osmangazi University-Cardio
Eskişehir, 26040
Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji
Eskişehir, 26040
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Hastanesi- Nefroloji
Istanbul, Bakirkoy, 34098
Istanbul University Cerrahpasa Medical Faculty
Istanbul, Bakirkoy, 34153
İstanbul Üniversitesi-Cerrahpaşa Kardiyoloji Enstitüsü
Istanbul, 34098
Istanbul Florence Nightingale Hospital
Istanbul, 34381
Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi EAH- Kardiyoloji
Istanbul, 34668
Ege Üniversitesi Hastanesi- Kardiyoloji
Izmir, 35100
Dokuz Eylül Üniversitesi Araştırma Uygulama Hastanesi-Kardiyoloji
Izmir, 35340
Kahramanmaras Sutcu Imam University
Kahramanmaraş, 46040
Erciyes Üniversitesi Hastanesi - Nefroloji
Kayseri, Melikgazi, 38039
Erciyes University Medial Faculty
Kayseri, 38039
Kocaeli University Nephrology Department
Kocaeli, 41380
Kocaeli Üniversitesi Araştıma ve Uygulama Hastanesi - Nefroloji
Kocaeli, 41380
Mersin Üniversitesi Hastanesi- Kardiyoloji
Mersin, 33343
Muğla Eğitim ve Araştırma Hastanesi
Muğla, 48050
South Korea26 sites
Dong-A University Hospital
Busan, 49201
Dong-A University Medical Center
Busan, 49201
Pusan National University Hospital
Busan, 49241
Daegu Catholic Univ. Medical Center
Daegu, 42472
Keimyung University Dongsan Hospital
Daegu, 42601
Keimyung University Dongsan Medical Center
Daegu, 42601
Chungnam National University Hospital
Daejeon, 35015
Wonju Severance Christian Hospital
Gangwon-do, 26426
National Health Insurance Corporation Ilsan Hospital
Goyang, 410-719
National Health Insurance Corporation Ilsan Hospital
Goyang-si, Gyeonggi-do, 10444
Chonnam National University Hospital
Gwangju, 61469
Hallym University Sacred Heart Hospital
Gyeonggi-do, 14068
Hanyang University GURI Hospital
Gyeonggi-do, 471-101
Gachon University Gil Medical Center
Incheon, 21565
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620
Nowon Eulji Medical Center, Eulji University
Seoul, 01830
Kyunghee University Medical Center
Seoul, 02447
Korea University Anam Hospital
Seoul, 02841
Seoul National University Hospital
Seoul, 03080
Severance Hospital, Yonsei University Health System
Seoul, 03722
Konkuk University Medical Center
Seoul, 05030
Kyung Hee University Hospital at Gangdong
Seoul, 05278
Seoul Saint Mary's Hospital
Seoul, 06591
The Catholic University of Korea, Seoul ST. Mary's Hospital
Seoul, 06591
KangNam Sacred Heart Hospital
Seoul, 07441
Korea University Guro Hospital
Seoul, 08308
Australia25 sites
Nightingale Research Adelaide
Adelaide, South Australia, 5000
Nightingale Research
Adelaide, South Australia, 5000
Royal Adelaide Hospital - Cardiology Department
Adelaide, South Australia, 5000
Royal Adelaide Hospital Cardiovascular Clinical Trials
Adelaide, South Australia, 5000
Sunshine Coast University Hospital
Birtinya, Queensland, 4575
Monash Health Heart
Clayton, Victoria, 3168
St Vincent's Hospital_Fitzroy_0
Fitzroy, Victoria, 3065
Canberra Hospital
Garran, Australian Capital Territory, 2605
The Canberra Hospital_Garran
Garran, Australian Capital Territory, 2605
Geelong Cardiology Research Unit
Geelong, Victoria, 3220
Gosford Renal Research
Gosford, New South Wales, 2250
Royal Hobart Hospital
Hobart, Tasmania, 7000
Advara HeartCare Joondalup
Joondalup, Western Australia, 6027
HeartCare WA (Joondalup)
Joondalup, Western Australia, 6027
St George Hospital
Kogarah, New South Wales, 2217
Advara HeartCare Leabrook
Leabrook, South Australia, 5068
HeartCare SA
Leabrook, South Australia, 5068
Core Research Group
Milton, Queensland, 4064
Melbourne Renal Research Group
Reservoir, Victoria, 3073
Sunshine Hospital - Western Centre for Health Research and Education
St Albans, Victoria, 3021
Sunshine Hospital
St Albans, Victoria, 3021
Royal North Shore Hospital
St Leonards, New South Wales, 2065
Latrobe Regional Hospital - Research Unit
Traralagon, Victoria, 3844
Westmead Applied Research Centre
Westmead, New South Wales, 2145
Illawarra Heart Health Centre
Wollongong, New South Wales, 2500
Italy24 sites
West Vicenza General Hospital
Arzignano (VI), 36071
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
Bergamo, Lombardy, 24127
Policlinico S. Orsola - Malpighi
Bologna, 40138
AO Cannizzaro
Catania, 95126
Azienda Ospedaliero-Universitaria Renato Dulbecco
Catanzaro, Cz, 88100
Università degli studi G. D'Annunzio Chieti Pescara - CAST
Chieti Scalo, 66100
A.O.U. Ferrara, Sant'Anna
Cona (Ferrara), Fe, 44124
AOU Careggi Firenze
Florence, 50134
IRCCS Azienda Ospedaliero Universitaria San Martino - IST
Genova, 16132
IRCCS Ospedale Policlinico San Martino
Genova, 16132
Ospedale San Raffaele S.r.l. - Unità Clinica Riabilitazione Specialistica Cardiologica
Milan, 20132
Centro Cardiologico Monzino
Milan, 20138
ASST degli Spedali Civili di Brescia-Presidio Ospedaliero di Montichiari
Montichiari, 25018
Azienda Ospedaliera Universitaria Federico II di Napoli
Naples, 80131
AOUP Giaccone Palermo
Palermo, 90127
ARNAS Ospedali Civico Di Cristina Benfratelli - Presidio Ospedaliero "Civio e Benfratelli"
Palermo, 90127
Fondazione IRCCS Policlinico San Matteo
Pavia, 27100
AOU Pisana Cisanello
Pisa, 56124
Policlinico Umberto I Seconda Clinica Medica
Roma, RM, 00161
Policlinico Tor Vergata
Roma, 00133
Policlinico A. Gemelli IRCCS
Roma, 00168
AOU S. Andrea
Rome, 00189
Azienda Sanitaria Univ Giuliano Isontina - SC Cardiologia
Trieste, 34128
AOUI Verona
Verona, 37126
South Africa24 sites
Cardiology Research_Bloemfontein
Bloemfontein, Free State, 9301
IATROS International
Bloemfontein, Free State, 9301
Josha Research
Bloemfontein, Free State, 9301
Helderberg Research Institute
Cape Town, Western Cape, 7130
Tread Research (Pty)Ltd
Cape Town, Western Cape, 7500
Tiervlei Trial Centre
Cape Town, Western Cape, 7530
Prof Rayner_Division of Nephrology
Cape Town, Western Cape, 7925
Dr Iftikhar Osman Ebrahim
Centurion, Gauteng, 0157
Excellentis Clinical Trial Consultants
George, Eastern Cape, 6529
TASK Eden Clinical Research Centre
George, Western Cape, 6529
Wits Bara Clinical Trial Site
Johannesburg, Gauteng, 2013
Tickerdoc Research (Pty) LTD
Johannesburg, Gauteng, 2157
WITS Clinical Research
Johannesburg, Gauteng, 2193
Dr Hendrik Snyman's Practice
Mossel Bay, Western Cape, 6500
Paarl Reserch Centre
Paarl, Western Cape, 7646
Paarl Research Centre
Paarl, Cape Town, Western Cape, 7646
EMMED Clinical Research
Pretoria, Gauteng, 0002
Jongaie Research
Pretoria, Gauteng, 0183
Synexus Watermeyer Clinical Research Centre
Pretoria, Gauteng, 0184
Clinical Trial Systems (CTC)
Pretoria, Gauteng, 0186
Roodepoort Medicross Clinical Research Centre
Roodepoort, Gauteng, 1724
Clinical Trials Network Helderberg (Pty) Ltd
Somerset West, Western Cape, 7130
Synexus Helderberg Clinical Research Centre
Somerset West, Western Cape, 7130
Mediclinic Medical Centre
Tongaat, KwaZulu-Natal, 4400
Ukraine23 sites
Chernivtsi Emergency Hospital - Therapeutic Department No.1
Chernivtsi, 58023
Reg Clin Hospital of Emergency Care, Bukovinian Medical Univ
Chernivtsi, 58023
Сlinical treatment and diagnostic centre 'Simedgroup'
Ivano-Frankivsk, 76008
City Clinical Hospital #27 (Kharkiv) - Intensive care department
Kharkiv, 61002
Institute of Therapy named after L.T.Malaya - Department of Prevention and Treatment of Kidney Diseases in Comorbid Conditions
Kharkiv, 61039
NI of Therapy na LT Malaya of NAMSU - Chr. Non-Communicable
Kharkiv, 61039
City Clinical Hospital #8 (Kharkiv) - Dept of Arterial and Ven Thrombosis
Kharkiv, 61178
Municipal Non-Profit Institution "City Clinical Hospital #8"
Kharkiv, 61178
Medical Centre "OkClinic +" - inpatient department
Kyiv, 02091
Kyiv City Clinical Hospital of Emergency Care - Infarction department
Kyiv, 02660
Kyiv City Clinical Hospital of Emergency Care - Infarction
Kyiv, 02660
"Medbud-Clinic" LLC - medical and preventive unit
Kyiv, 03037
Medbud-Clinic LLC
Kyiv, 03037
Clinical Hosp on the railway line №2 branch PHC JSC Ukrzaliz
Kyiv, 03049
Kyiv Railway Clinical Hospital #2 - day care department
Kyiv, 03049
M.D.Strazheska Institute of Cardiology of NAMSU - Intensive care and resuscitation department
Kyiv, 03151
M.D.Strazheska Institute of Cardiology of NAMSU - Department of non-coronary heart diseases
Kyiv, 03680
Medical Center 'Consilium Medical' - clinical consultation department
Kyiv, 04050
Kyiv Regional Clinical Hospital - Consultative medical department
Kyiv, 04053
"Center of Family Medicine Plus" LLC - Outpatient department
Kyiv, 04210
City Clinical Hospital #10 (Zaporizhia) - Therapeutics department
Zaporizhia, 69001
University Clinic of Zaporizhia State Medical and Pharm University - Cardiology department
Zaporizhzhya, 69063
Central City Hospital #1 - Scientific-Research centre
Zhytomyr, 10002
Russia22 sites
Reg. State Budget Healthc. Inst. Regional Clinical Hospital
Barnaul, 656024
RBSHI "Altay Regional Cardiology Dispensary"
Barnaul, 656055
Road Clinical Hospital at station Chelyabinsk
Chelyabinsk, 454048
Chita State Medical Academy
Chita, 672000
Irkutsk State Medical Academy of Postgraduate Education
Irkutsk, 664049
FSB EI "Kazan' State Medical University"
Kazan', 420029
SAI of Health "Interregional Clinic Diagnostic Center"
Kazan', 420101
Institute of Complex Problems of Cardio-Vascular Diseases
Kemerovo, 650002
National Medical Research Center of Cardiology
Moscow, 121552
Pirogov Russian National Research Medical University MoH
Moscow, 129226
Friendship University of Russia MCCH base
Moscow, 129327
LLC RC Medical
Novosibirsk, 630005
State Novosibirsk regional clinical hospital
Novosibirsk, 630087
Limited Law Company "Healthy Family" Medicine Center"
Novosibirsk, 630099
SBIH Perm region "City Clinical Hospital #2 n.a. F.K. Gral"
Perm, 614068
Republican Hospital n.a. V. A. Baranov
Petrozavodsk, 185019
Medical Research Institute LLC
Saint Petersburg, 196084
SPb BHI "City Pokrovskaya Hospital"
Saint Petersburg, 199106
Regional Clinical cardiological dispensary n.a. Polyakov
Samara, 443070
City Hospital #4, Sochi
Sochi, 354057
Tomsk National Research Medical Center of the RAS
Tomsk, 634012
Tomsk National Research Medical Center of the RAS
Tomsk, 634034
Brazil21 sites
Hospital Felicio Rocho
Belo Horizonte, Minas Gerais, 30110-934
AngioCor Blumenau
Blumenau, Santa Catarina, 89020-430
Grupo AngioKormann
Blumenau, Santa Catarina, 89020-430
Hospital do Coração do Brasil - Rede Do'r
Brasília, Federal District, 70390-700
Instituto de Pesquisa Clínica de Campinas
Campinas, São Paulo, 13060-080
PUCCAMP - Hospital e Maternidade Celso Pierro
Campinas, São Paulo, 13060-803
i9 Pesquisas Clínicas
Campinas, São Paulo, 13092-133
Instituto Pró-Renal Brasil
Curitiba, Paraná, 80440-020
Núcleo de Pesquisa Clínica S/S
Curitiba, Paraná, 80730-150
Irmandade da Santa Casa de Misericordia de Porto Alegre
Porto Alegre/ RS, 90035-074
HBA S/A Assistência Médica e Hospitalar
Salvador, 41810-011
Praxis Pesquisa Médica
Santo André, São Paulo, 09090-790
CEMEC - Centro Multidisciplinar de Estudos Clínicos
São Bernardo Do Campo/SP, 09715-090
CIP Centro Integrado de Pesquisas do Hospital de Base
São José do Rio Preto, São Paulo, 15090-000
CPQuali Pesquisa Clínica Ltda
São Paulo, São Paulo, 01228-000
Impar Serviços Hospitalares S/A
São Paulo, São Paulo, 01409-001
Instituto do Coração - HCFMUSP
São Paulo, São Paulo, 05403-000
Centro de Diabetes e Obesidade - HRim e Hipertensao
São Paulo - SP, 04038-002
Eurolatino Medical Research Center
Uberlândia, Minas Gerais, 38400-500
Centro de Diag. e Pesquisa da Osteoporose do Espírito Santo
Vitória, Espírito Santo, 29055-450
Integral Pesquisa e Ensino
Votuporanga, São Paulo, 15500-269
Thailand21 sites
King Chulalongkorn Memorial Hospital
Bangkok, Patumwan, 10330
Phramongkutklao Hospital_Nephrology
Bangkok, Rajathewee, 10400
Ramathibodi Hospital
Bangkok, Thung Phayathai Subdistrict, 10400
Chulabhorn hospital_Cardiovascular
Bangkok, 10210
Cardio-Vajira
Bangkok, 10300
Vajira Hospital - Cardio
Bangkok, 10300
King Chulalongkorn Memorial Hospital
Bangkok, 10330
Siriraj Hospital
Bangkok, 10700
Siriraj Hospital
Bangkok Noi, Bangkok, 10700
Maharaj Nakorn Chiang Mai Hospital_Nephrology
Chiang Mai, Mueang Chiang Mai, 50200
Maharaj Nakorn Chiang Mai Hospital
Chiang Mai, 50200
Rihes - Research Institute for Health Sciences
Chiang Mai, 50200
RIHES-CMU_Research Institute for Health Sciences
Chiang Mai, 50200
Songklanagarind Hospital
Hat Yai, Changwat Songkhla, 90110
Srinagarind Hospital
Khon Kaen, 40002
Thammasat University Hospital
Klong Luang, Pathumthani, Changwat Pathum Thani, 12120
Maharat Nakhon Ratchasima Hospital
Nakhon Ratchasima, 30000
Thammasat Hospital_Cardiology
Pathum Thani, 12120
Songklanagarind Hospital
Songkhla, 90110
Sunpasitthiprasong Hospital_Pediatrics Department
Ubon Ratchathani, 34000
Sunpasitthiprasong Hospital
Ubon Ratchathani, 34000
Netherlands19 sites
Noordwest Ziekenhuisgroep
Alkmaar, 1815 JD
ZGT Almelo
Almelo, 7609 PP
Ziekenhuis Groep Twente Almelo
Almelo, 7609 PP
Academisch Medisch Centrum
Amsterdam, 1105 AZ
AmsterdamUMC AMC
Amsterdam, 1105 AZ
Gelre Ziekenhuizen Apeldoorn
Apeldoorn, 7334 DZ
Gelre Zkh Apeldoorn
Apeldoorn, 7334 DZ
Amphia Ziekenhuis
Breda, 4818 CK
St Jansdal
Harderwijk, 3844 DG
Ziekenhuis St Jansdal - Cardiologie
Harderwijk, 3844 DG
Tergooi, Hilversum
Hilversum, 1212 VG
Tergooi, locatie Hilversum
Hilversum, 1213 XZ
Leids Universitair Medisch Centrum
Leiden, 2333 ZA
Bravis Ziekenhuis
Roosendaal, 4708 AE
Bravis Zkh Roosendaal
Roosendaal, 4708 AE
Ikazia Ziekenhuis
Rotterdam, 3083 AN
D & A Research B.V.
Sneek, 8601 ZR
Zaans Medisch Centrum - Cardiologie
Zaandam, 1502 DV
Zaans Medisch Centrum
Zaandam, 1502 DV
Lithuania17 sites
Klinikiniai sprendimai, Alytus
Alytus, 63200
Klinikiniai sprendimai, Alytus
Alytus, LT-63200
Lithuanian university of health sciences Clinical hospital
Kaunas, 47144
Kaunas City Polyclinic, Silainiu department
Kaunas, 48259
Klinikiniai sprendimai, Kaunas
Kaunas, 49387
JSC "Saules seimos medicinos centras"
Kaunas, 49449
Hospital of Lithuanian University of Health Sciences Kauno klinikos
Kaunas, 50161
Kaunas City polyclinic Dainava Branch
Kaunas, 51270
Klinikiniai sprendimai, Kaunas
Kaunas, LT-49387
Kaunas City polyclinic Dainava Branch
Kaunas, LT-51270
Klaipeda university hospital
Klaipėda, 92288
Klaipeda university hospital
Klaipėda, LT-92288
Republican Panevezys Hospital
Panevezys, 35144
Republican Panevezys Hospital
Panevezys, LT-35144
Pirmoji Viltis
Šiauliai, LT-76206
JSC Inlita Lazdynai CMC
Vilnius, 04130
JSC Inlita Santaros
Vilnius, 08406
Slovakia17 sites
CARDIOCONSULT, s.r.o.
Bratislava, 811 04
I. Interna klinika LF UK a UNB
Bratislava, 81369
DIABEDA s.r.o.
Bratislava, 831 06
1. Interna klinika SZU a UNB
Bratislava, 83305
Klinika kardiologie a angiologie LF SZU
Bratislava, 83348
CINRE s. r. o., Oddelenie akutnej kardiologie a koronarna JIS
Bratislava, 841 03
Medical group Kosice s.r.o.
Košice, 040 01
VITAL, s.r.o.
Levice, 934 01
Narodny Endokrinologicky a diabetologicky ustav
Ľubochňa, 03491
KARDIO 1, s.r.o., Kardiologicka ambulancia
Lučenec, 984 01
1. interna klinika, Univerzitna nemocnica Martin
Martin, 036 59
InterStom, s.r.o.
Nitra, 949 11
KARDIOMED NZ, s.r.o.
Nové Zámky, 940 01
Medical KG, s.r.o.
Piešťany, 92101
Kardiologicka ambulancia
Považská Bystrica, 017 01
FNsP J. A. Reimana Presov, Klinika kardiologie
Prešov, 08-181
IMCORE, s.r.o.
Prešov, 080 01
Argentina16 sites
Centro Medico Lebensohn
Buenos Aires, B6000BHA
Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli
Buenos Aires, C1425AGC
Mautalen Salud e investigación
CABA, Buenos Aires, C1128 AAF
Sanatorio Finochietto
CABA, Buenos Aires, C1213
Instituto Cardiovascular Buenos Aires
CABA, Buenos Aires, C1428ART
CEMEDIC
CABA, Buenos Aires, C1440CFD
Centro Médico Viamonte SRL
CABA, C1120AAC
Centro de Educación Médica e Investigaciones Clínicas Saaved
Capital Federal, C1431FWO
Cardiología Palermo Duplicate
Ciudad Autónoma de Buenos Aire, 1425
Instituto Médico DAMIC
Córdoba, X5003DCE
Hospital Italiano de la Plata
La Plata, Buenos Aires, B 1900AXI
Centro de Investigaciones Médicas Clínica de Fracturas y Or
Mar del Plata, Buenos Aires, B7600GNY
Centro de Investigaciones Médicas Mar del Plata
Mar del Plata, Buenos Aires, B7600GNY
Instituto Médico CER
Quilmes - Buenos Aires, B1878DVB
Investigaciones Clinicas Tucuman
San Miguel de Tucumán, Tucumán., T4000
Instituto de Investigaciones Clinicas San Nicolás
San Nicolás, B2900
Malaysia16 sites
Hospital Sultanah Bahiyah
Alor Star, Kedah, 05460
Hospital Canselor Tuanku Muhriz UKM
Cheras, Kuala Lumpur, 56000
Hospital Raja Permaisuri Bainun Ipoh
Ipoh, Perak, 30450
Hospital Raja Permaisuri Bainun Ipoh
Ipoh, Perak, 30450
Hospital Raja Perempuan Zainab II
Kota Bharu, Kelantan, 15586
Hospital Universiti Sains Malaysia_Kota Bharu, Kelantan
Kota Bharu, Kelantan, 16150
Sarawak Heart Centre
Kota Samarahan, Sarawak, 94300
National Heart Institute
Kuala Lumpur, 50400
University Malaya Medical Centre
Lembah Pantai, Kuala Lumpur, 59100
Hospital Miri
Miri, Sarawak, 98000
Hospital Seberang Jaya
Pulau Pinang, 13700
Hospital Queen Elizabeth II
Sabak Bernam, 88300
Hospital Tuanku Jaafar
Seremban, 70300
Hospital Seri Manjung
Seri Manjung, Perak, 32040
University Technology MARA (UiTM) - Sg Buloh
Sungai Buloh, Selangor, 47000
Hospital Sultan Abdul Halim
Sungai Petani, Kedah, 08000
Mexico15 sites
Centro de Investigación Cardiometabólica de Aguascalientes
Aguascalientes, 20230
Clínicos Asociados BOCM, S.C.
Benito Juárez, Mexico City, 03300
Hospital Angeles de Culiacan
Culiacán, Sinaloa, 80020
Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada, S.C.
Culiacán, Sinaloa, 80230
Centro para el Desarrollo de la Medicina y la Asistencia
Culiacán, Sinaloa, 80230
Consultorio Privado Dr Gabriel Arturo Ramos
Guadalajara, Jalisco, 44657
Centro de Investigacion Clinica Endocrinologica de Jalisco
Guadalajara, Jalisco, 44670
Clínicos Asociados BOCM, S.C.
Mexico City, México, D.F., 03300
Internal Medicine Clin Trials
Monterrey, Nuevo León, 64020
Cardiolink Clin Trials S.C.
Monterrey, Nuevo León, 64060
Unidad Biomedica Avanzada Monterrey
Monterrey, Nuevo León, 64460
Centro de Estudios Clínicos de Querétaro S.C.
Querétaro, 76000
Centro de atención e investigación cardiovascular del Potosí
San Luis Potosí City, San Luis Potosí, 78200
CINCAME
Tijuana, Estado de Baja California, 22500
FAICIC S. de R.L. de C.V.
Veracruz, 91900
Portugal14 sites
ULS De Almada-Seixal E.P.E. - Hospital Garcia de Orta
Almada, 2805-267
ULS Da Regiao De Aveiro E.P.E. - Hospital Infante D. Pedro
Aveiro, 3814-501
ULS De Braga, E.P.E. - Hospital de Braga
Braga, 4710-243
ULS De Lisboa Ocidental E.P.E. - Hospital de Santa Cruz
Carnaxide, Lisbon District, 2790-134
Unidade De Coimbra, E.P.E. - Hospital da Universidade de Coimbra
Coimbra, 3000-561
ULS De Tâmega e Sousa E.P.E. - Hospital Padre Américo
Guilhufe - Penafiel, 4560-136
APDP - Associação Protectora dos Diabéticos de Portugal
Lisbon, 1250-230
ULS Lisboa Ocidental, E.P.E_Hospital São Francisco Xavier_Hospital de Dia de Especialidades Médicas
Lisbon, 1449-005
Unidade De Santa Maria E.P.E. - Hospital de Santa Maria
Lisbon, 1649-035
ULS De São João, E.P.E. - Hospital de São João
Porto, 4200-319
ULS De Matosinhos E.P.E.- Hospital Pedro Hispano
Senhora Da Hora, Matosinhos, Matosinhos, 4464-513
ULS Da Arrábida, E.P.E._Hospital de São Bernardo
Setúbal, 2910-446
ULS Do Alto Minho E.P.E. - Hospital de Santa Luzia
Viana do Castelo, 4904-858
ULS De Gaia/Espinho E.P.E. - Hospital Eduardo Santos Silva
Vila Nova de Gaia, 4434-502
Belgium12 sites
AZORG Aalst - Moorselbaan
Aalst, 9300
Imeldaziekenhuis - Bonheiden - Department of Endocrinology
Bonheiden, 2820
Imelda
Bonheiden, 2820
AZ Klina - Brasschaat - Cardiology
Brasschaat, 2930
AZ Sint-Jan - Campus Brugge_Brugge
Bruges, 8000
AZ Sint-Jan - Campus Brugge
Bruges, 8000
Ziekenhuis Oost Limburg - Cardiology
Genk, 3600
Ziekenhuis Oost-Limburg
Genk, 3600
AZ Groeninge - Kortrijk - Cardiology
Kortrijk, 8500
CHR de la Citadelle
Liège, 4000
AZ Sint-Maarten Mechelen - Cardiology
Mechelen, 2800
AZ OOSTENDE (Campus DAMIAAN)
Ostend, 8400
Serbia12 sites
CHC Zvezdara, Clinical department for endocrinology
Belgrade, 11000
Clinical centre of Serbia, Clinic for cardiology
Belgrade, 11000
Clinical Centre of Serbia, Emergency Centre, Department of Cardiology
Belgrade, 11000
Emergency Internal Medicine Clinic
Belgrade, 11000
Endocrinology, Diabetes and Metabolism Diseases Clinic
Belgrade, 11000
Institute for Cardiovascular Diseases ''Dedinje''
Belgrade, 11000
Clinical Hospital Centre Zemun
Belgrade, 11080
Institute for Cardiovascular Diseases of Vojvodina - Sremska Kamenica
Kamenitz, 21204
Clinical Centre Kragujevac, Internal Diseases Clinic, Endocrinology department
Kragujevac, 34000
University Clinical Centre Nis, Clinic for Cardiology
Niš, 18108
Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
Novi Sad, Vojvodina, 21000
Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
Novi Sad, 21000
Spain12 sites
Hospital Universitario de Cruces
Barakaldo, 48903
Hospital Vithas Sevilla
Castilleja de la Cuesta, 41950
Hospital Reina Sofia
Córdoba, 14004
Hospital Univ. Virgen de la Arrixaca
El Palmar, Murcia, 30120
Bellvitge Universitary Hospital
L' Hospitalet Del Llobregat, 08907
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Madrid, 28222
H Virgen del Camino_Sanlúcar_Medicina Interna
Sanlúcar de Barrameda, 11540
Hospital Clinico Universitario de Valencia
Valencia, 46010
Hospital Clínico Universitario de Valencia
Valencia, 46010
Hospital Universitario Doctor Peset
Valencia, 46017
Hosp. Virgen de las Montañas_Medicina Interna
Villamartín, 11650
Hospital Univ. Miguel Servet_Medicina Interna
Zaragoza, 50009
Taiwan11 sites
HsinChu MacKay Memorial Hospital
Hsinchu, 300
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807
E-DA Hospital-Department of Cardiology
Kaohsiung City, 82445
National Cheng Kung University Hospital
Tainan, 704
Chi Mei Medical Center
Tainan, 710
National Taiwan University Hospital_main
Taipei, 100
Taipei Medical University Hospital
Taipei, 110
Cheng Hsin General Hospital
Taipei, 112
Taipei Veterans General Hospital
Taipei, 112
Chang Gung Memorial Hospital, Linkou
Taoyuan, 333
National Yang Ming Chiao Tung University Hospital Lanyang Campus
Yilan, 260006
Croatia9 sites
Specijalna bolnica za medicinsku rehabilitaciju Krapinske Toplice_Cardiology
Krapinske Toplice, Krapinsko Zagorska County, 49217
Clinical Hospital Centre Rijeka_Cardiology
Rijeka, 51000
Clinical Hospital Centre Rijeka_Nefrology
Rijeka, 51000
KBC Rijeka, Zavod za kardiomiopatije
Rijeka, 51000
KBC Split / Krizine/ Kardiologija
Split, 21000
KB Dubrava, Zavod za bolesti srca i krvnih zila
Zagreb, City of Zagreb, 10000
Poliklinika Solmed
Zagreb, City of Zagreb, 10000
KBC Zagreb_Cardiology
Zagreb, 10000
KBC Zagreb_Nefrology
Zagreb, 10000
Denmark9 sites
Aarhus Universitetshospital, Hjertesygdomme
Aarhus N, 8200
Aalborg Universitetshospital Hjertemedicinsk Afdeling
Gistrup, 9260
Regionshospitalet Gødstrup, Hjertesygdomme
Herning, 7400
Holbæk Sygehus - Forskningsenheden, Medicinsk Afdeling, afs. 44-4
Holbæk, Region Sjælland, 4300
Hvidovre Hospital Hjertemedicinsk
Hvidovre, 2650
Kolding Sygehus Karkirurgi
Kolding, 6000
Sjællands Universitetshospital, Roskilde - Kardiologisk Afdeling
Roskilde, 4000
Svendborg Sygehus - Kardiologisk
Svendborg, 5700
Viborg Sygehus
Viborg, 8800
Hungary9 sites
EURÉKA-CENTER Orvosi és Szolgáltató Betéti Társaság
Baja, 6500
Tagore Medical Center
Balatonfüred, 8230
Dr. Lakatos Ferenc Kardiológus ,Belgyógyász Magán szakrendelés
Békéscsaba, Bekes County, 5600
Gottsegen György Országos Kardiológiai Intézet
Budapest, 1096
Jahn Ferenc Dél-pesti Kórház és Rendelőintézet
Budapest, 1204
DE KK Kardiológiai és Szívsebészeti klinika
Debrecen, 4032
Selye János Kórház
Komárom, Komárom-Esztergom, 2921
Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ
Szeged, 6725
Léda Platán Magánklinika
Zalaegerszeg, Zala County, 8900
Israel7 sites
Wolfson MC - Diabetes Clinic
Holon, 58100
Hadassah Ein Karam MC - Cardio Department
Jerusalem, 91120
Western Galilee MC - Cardiology Department
Nahariya, 22100
Rabin MC Beilinson - Heart Failure Unit
Petah Tikva, 49100
Kaplan MC - Nephrology unit
Rehovot, 7661041
Sourasky MC - Cardio Vascular Research Center
Tel Aviv, 6423906
Sheba MC - Cardiology Clinical Research Unit
Tel HaShomer, 5265601
Sweden7 sites
Sahlgrenska US - Njurmedicin
Gothenburg, 413 45
Karolinska Universitetssjukhuset, Huddinge
Huddinge, Stockholm County, 141 85
Clemenstorgets Hjärtmottagning
Lund, 222 21
Skåne US - Forskningsmottagning Internmedicin (tidigare KFE)
Malmö, 205 02
Örebro US - Njursektionen
Örebro, 70185
KS Solna - FOU hjärta- kärl Mottagningen
Stockholm, 171 64
Uppsala US - Forskning njurmedicin
Uppsala, 751 85
Czechia6 sites
Edumed Broumov
Broumov, 550 01
KARDIOLOGIE - LIBEREC s.r.o.
Liberec, 460 01
EDUMED s.r.o.
Náchod, 547 01
IKEM Klinika nefrologie
Prague, 140 21
Medicon a.s.
Prague, 170 00
Nemocnice Slany
Slaný, 274 01
Latvia6 sites
Ari Med
Daugavpils, 5401
Daugavpils Regional Hospital
Daugavpils, 5417
Zemgales diabetes centre
Jelgava, 3001
P. Stradins Clinical University Hospital
Riga, 1002
Adoria
Riga, 1011
Riga East Clinical University Hospital - Clinic "Gailezers"
Riga, 1079
About this study
Official title: ZEUS - Effects of Ziltivekimab Versus Placebo on Cardiovascular Outcomes in Participants With Established Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease and Systemic Inflammation
This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation.
Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). This is known as the study medicine. Which treatment participants get is decided by chance. Participants chance of getting ziltivekimab or placebo is the same.
Read more
Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine doctors cannot prescribe.
Participants will get the study medicine in a pre filled syringe. Participants will need to use the pre filled syringe to inject the study medicine into a skinfold once-monthly.
The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have blood and urine samples taken at most of the clinic visits.
Participants will have their heart examined using sound waves (echocardiography) and electrodes (electrocardiogram).
Women cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period.
- Conditions
- Cardiovascular Risk, Chronic Kidney Disease, Inflammation
- Being tested
- Ziltivekimab B, Ziltivekimab C, Placebo (Ziltivekimab B), Placebo (Ziltivekimab C)
- Medical subject headings
- Renal Insufficiency, Chronic, Inflammation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ziltivekimab BDrug
Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.
Ziltivekimab CDrug
Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.
Placebo (Ziltivekimab B)Drug
Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.
Placebo (Ziltivekimab C)Drug
Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.
| Study group | Role | What they receive |
|---|---|---|
| Ziltivekimab | Experimental | Participants will receive Ziltivekimab B or Ziltivekimab C subcutaneously once monthly for up to 4 years. Receives: Drug: Ziltivekimab B; Drug: Ziltivekimab C |
| Placebo | Placebo comparator | Participants will receive either placebo (Ziltivekimab B) or placebo (Ziltivekimab C) subcutaneously once monthly for up to 4 years. Receives: Drug: Placebo (Ziltivekimab B); Drug: Placebo (Ziltivekimab C) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to first occurrence of 3-point Major Adverse Cardiovascular Event (MACE), a composite endpoint consisting of: Cardiovascular (CV) death, non-fatal Myocardial Infarction (MI) and non-fatal stroke
Months
Measured: From randomisation (month 0) to end-of-study (up to 48 months)
Secondary outcomes (20)
Time to first occurrence of expanded MACE, a composite endpoint consisting of: CV death, non-fatal MI, non-fatal stroke and hospitalisation for unstable angina pectoris requiring urgent coronary revascularisation
Months
Measured: From randomisation (month 0) to end-of-study (up to 48 months)
Number of heart failure hospitalisations or urgent heart failure visits or CV deaths
Count
Measured: From randomisation (month 0) to end-of-study (up to 48 months)
Time to first occurrence of a composite kidney endpoint consisting of: CV death, onset of persistent atleast 40 percent (%) reduction in eGFR (CKD-epidemiology collaboration [CKD-EPI]) compared with baseline, kidney failure
Months
Measured: From randomisation (month 0) to end-of-study (up to 48 months)
Time to occurrence of all-cause mortality
Months
Measured: From randomisation (month 0) to end-of-study (up to 48 months)
Time to first occurrence of each of the individual components of the expanded MACE endpoint and the kidney composite endpoint.
Months
Measured: From randomisation (month 0) to end-of-study (up to 48 months).
Time to first occurrence of MI (fatal and non-fatal).
Months
Measured: From randomisation (month 0) to end-of-study (up to 48 months).
Time to first occurrence of stroke (fatal and non-fatal).
Months
Measured: From randomisation (month 0) to end-of-study (up to 48 months).
Time to first occurrence of a composite MACE endpoint consisting of: all-cause mortality, non-fatal MI and non-fatal stroke
Months
Measured: From randomisation (month 0) to end-of-study (up to 48 months).
Time to first occurrence of a 4-component kidney endpoint consisting of: onset of persistent at least 40% reduction in eGFR (CKD-EPI) compared with baseline, kidney failure
Months
Measured: From randomisation (month 0) to end-of-study (up to 48 months).
Time to first occurrence of coronary revascularisation
Months
Measured: From randomisation (month 0) to end-of-study (up to 48 months).
Change in Urinary Abumin-to-Ceatinine ratio (UACR).
Percentage
Measured: From randomisation (month 0) to 2 years (24 months).
Change in eGFR (CKD-EPI))
mL/min/1.73 m^2
Measured: From randomisation (month 0) to 2 years (24 months)
Annual rate of change in eGFR (CKD-EPI) (total eGFR slope)
mL/min/1.73 m^2/ year
Measured: From randomisation (month 0) to end-of-study (up to 48 months).
Change in high-sensitivity C-reactive protein (hs-CRP)
Percentage
Measured: From randomisation (month 0) to 2 years (24 months
Change in N-terminal-pro-brain natriuretic peptide ( NT-pro-BNP)
Percentage
Measured: From randomisation (month 0) to 2 years (24 months)
Change in left ventricular ejection fraction (LVEF)
Percentage
Measured: From randomisation (month 0) to 2 years (24 months)
Number of events of atrial fibrillation
Count
Measured: From randomisation (month 0) to end-of-study (up to 48 months).
Change in haemoglobin
Grams per deciliter (g/dL)
Measured: From randomisation (month 0) to 2 years (24 months)
Number of hospitalisations with infection as primary cause or death due to infection.
Count
Measured: From randomisation (month 0) to end-of-study (up to 48 months).
Change in Short Form 36 (SF-36) Physical Component Score (PCS)
Score on scale
Measured: From randomisation (month 0) to 2 years (24 months)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Aug 2021
- Study start30 Aug 2021
- Primary completion9 Jun 2026
- Study completion9 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Cardiovascular RiskStudies of the same condition, open and under way.
- More trials run by Novo Nordisk A/SThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 6,385 participants (actual)
Sponsor and investigators
- Lead sponsor
- Novo Nordisk A/S
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Clinical Transparency (dept. 2834), Study director, Novo Nordisk A/S
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05021835
- Sponsor's protocol ID
- EX6018-4758
- Other IDs
- U1111-1259-3422, 2023-506926-35, jRCT2021210033, 2023
- Acronym
- ZEUS
- Status last verified
- Sep 2026
- First submitted
- 19 Aug 2021
- Last updated
- 28 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: According to the Novo Nordisk disclosure commitment on novonordisk-trials.com
Publications
Byambaa E, Roshanravan B, Berglund L. Lipoprotein(a) and CKD: Insights into New Therapeutic Opportunities. Clin J Am Soc Nephrol. 2026 Aug 1;21(8):1469-1481. doi: 10.2215/CJN.0000000968. Epub 2025 Dec 2.
PubMed 41329869In Het Panhuis W, Thiemann E, van Dijk DMAH, Been B, Jarrett KE, Meurs A, Kooijman S, Hovingh MV, Modder M, van Os BW, Sluiter TJ, Blomberg N, Pronk ACM, Afkir S, Streefland TCM, Lalai RA, Taveras MO, Zhang S, Adams TE, Terry LV, Turpin-Nolan SM, de Vries MR, Giera M, Rose-John S, Zelcer N, de Boer JF, de Aguiar Vallim TQ, Febbraio MA, Rensen PCN, Schonke M. The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice. Sci Adv. 2025 Oct 24;11(43):eadx3794. doi: 10.1126/sciadv.adx3794. Epub 2025 Oct 24.
PubMed 41134879Mohammadnia N, van Broekhoven A, Bax WA, Eikelboom JW, Mosterd A, Fiolet ATL, Tijssen JGP, Thompson PL, de Kleijn DPV, Tsimikas S, Cornel JH, Yeang C, El Messaoudi S. Interleukin-6 modifies Lipoprotein(a) and oxidized phospholipids associated cardiovascular disease risk in a secondary prevention cohort. Atherosclerosis. 2025 Jun;405:119211. doi: 10.1016/j.atherosclerosis.2025.119211. Epub 2025 Apr 26.
PubMed 40318255
Study at a glance
From the registry record, last updated by the sponsor on 28 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- ZEUS - Effects of Ziltivekimab Versus Placebo on Cardiovascular Outcomes in Participants With Established Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease and Systemic Inflammation
- ClinicalTrials.gov ID
- NCT05021835
- Acronym / sponsor ID
- ZEUS / EX6018-4758
- Conditions
- Cardiovascular Risk, Chronic Kidney Disease, Inflammation
- Phase
- Phase 3
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 6,385 participants (actual)
- Lead sponsor
- Novo Nordisk A/SIndustry (pharma, biotech, devices)
- Study start
- 30 Aug 2021 (actual)
- Primary completion
- 9 Jun 2026 (actual)
- Study completion
- 9 Jun 2026 (actual)
- First posted
- 26 Aug 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation.
Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). This is known as the study medicine. Which treatment participants get is decided by chance. Participants chance of getting ziltivekimab or placebo is the same.
Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine doctors cannot prescribe.
Participants will get the study medicine in a pre filled syringe. Participants will need to use the pre filled syringe to inject the study medicine into a skinfold once-monthly.
The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have blood and urine samples taken at most of the clinic visits.
Participants will have their heart examined using sound waves (echocardiography) and electrodes (electrocardiogram).
Women cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Ziltivekimab | Experimental | Drug: Ziltivekimab B, Drug: Ziltivekimab CParticipants will receive Ziltivekimab B or Ziltivekimab C subcutaneously once monthly for up to 4 years. |
| Placebo | Placebo comparator | Drug: Placebo (Ziltivekimab B), Drug: Placebo (Ziltivekimab C)Participants will receive either placebo (Ziltivekimab B) or placebo (Ziltivekimab C) subcutaneously once monthly for up to 4 years. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Chronic kidney disease defined by one of the below:
- Serum high-sensitivity C-reactive protein (hs-CRP) greater than or equal to 2 milligram per liter (mg/L)
- Evidence of atherosclerotic cardiovascular disease (ASCVD) by one or more of the following:
Key exclusion criteria (4 listed)
- Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.
- Myocardial infarction, stroke, hospitalisation for unstable angina pectoris, or transient ischaemic attack within 60 days prior to randomisation (visit 2).
- Planned coronary, carotid or peripheral artery revascularisation known on the day of randomisation (visit 2).
- Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit 2) or any major surgical procedure planned at the time of randomisation (visit 2).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ziltivekimab BAdministered subcutaneously (s.c., under skin) once-monthly added to standard of care. | Drug | Ziltivekimab |
| Ziltivekimab CAdministered subcutaneously (s.c., under skin) once-monthly added to standard of care. | Drug | Ziltivekimab |
| Placebo (Ziltivekimab B)Administered subcutaneously (s.c., under skin) once-monthly added to standard of care. | Drug | Placebo |
| Placebo (Ziltivekimab C)Administered subcutaneously (s.c., under skin) once-monthly added to standard of care. | Drug | Placebo |
Primary outcome
Time to first occurrence of 3-point Major Adverse Cardiovascular Event (MACE), a composite endpoint consisting of: Cardiovascular (CV) death, non-fatal Myocardial Infarction (MI) and non-fatal stroke
Time frame: From randomisation (month 0) to end-of-study (up to 48 months)
Months
20 secondary outcomes
Time to first occurrence of expanded MACE, a composite endpoint consisting of: CV death, non-fatal MI, non-fatal stroke and hospitalisation for unstable angina pectoris requiring urgent coronary revascularisation
Time frame: From randomisation (month 0) to end-of-study (up to 48 months)
Number of heart failure hospitalisations or urgent heart failure visits or CV deaths
Time frame: From randomisation (month 0) to end-of-study (up to 48 months)
Time to first occurrence of a composite kidney endpoint consisting of: CV death, onset of persistent atleast 40 percent (%) reduction in eGFR (CKD-epidemiology collaboration [CKD-EPI]) compared with baseline, kidney failure
Time frame: From randomisation (month 0) to end-of-study (up to 48 months)
Time to occurrence of all-cause mortality
Time frame: From randomisation (month 0) to end-of-study (up to 48 months)
Time to first occurrence of each of the individual components of the expanded MACE endpoint and the kidney composite endpoint.
Time frame: From randomisation (month 0) to end-of-study (up to 48 months).
Time to first occurrence of MI (fatal and non-fatal).
Time frame: From randomisation (month 0) to end-of-study (up to 48 months).
Time to first occurrence of stroke (fatal and non-fatal).
Time frame: From randomisation (month 0) to end-of-study (up to 48 months).
Time to first occurrence of a composite MACE endpoint consisting of: all-cause mortality, non-fatal MI and non-fatal stroke
Time frame: From randomisation (month 0) to end-of-study (up to 48 months).
Time to first occurrence of a 4-component kidney endpoint consisting of: onset of persistent at least 40% reduction in eGFR (CKD-EPI) compared with baseline, kidney failure
Time frame: From randomisation (month 0) to end-of-study (up to 48 months).
Time to first occurrence of coronary revascularisation
Time frame: From randomisation (month 0) to end-of-study (up to 48 months).
Change in Urinary Abumin-to-Ceatinine ratio (UACR).
Time frame: From randomisation (month 0) to 2 years (24 months).
Change in eGFR (CKD-EPI))
Time frame: From randomisation (month 0) to 2 years (24 months)
Annual rate of change in eGFR (CKD-EPI) (total eGFR slope)
Time frame: From randomisation (month 0) to end-of-study (up to 48 months).
Change in high-sensitivity C-reactive protein (hs-CRP)
Time frame: From randomisation (month 0) to 2 years (24 months
Change in N-terminal-pro-brain natriuretic peptide ( NT-pro-BNP)
Time frame: From randomisation (month 0) to 2 years (24 months)
Change in left ventricular ejection fraction (LVEF)
Time frame: From randomisation (month 0) to 2 years (24 months)
Number of events of atrial fibrillation
Time frame: From randomisation (month 0) to end-of-study (up to 48 months).
Change in haemoglobin
Time frame: From randomisation (month 0) to 2 years (24 months)
Number of hospitalisations with infection as primary cause or death due to infection.
Time frame: From randomisation (month 0) to end-of-study (up to 48 months).
Change in Short Form 36 (SF-36) Physical Component Score (PCS)
Time frame: From randomisation (month 0) to 2 years (24 months)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Sep 2026.
- Derived from this study: PubMed 41329869Byambaa E, Roshanravan B, Berglund L. Lipoprotein(a) and CKD: Insights into New Therapeutic Opportunities. Clin J Am Soc Nephrol. 2026 Aug 1;21(8):1469-1481. doi: 10.2215/CJN.0000000968. Epub 2025 Dec 2.
- Derived from this study: PubMed 41134879In Het Panhuis W, Thiemann E, van Dijk DMAH, Been B, Jarrett KE, Meurs A, Kooijman S, Hovingh MV, Modder M, van Os BW, Sluiter TJ, Blomberg N, Pronk ACM, Afkir S, Streefland TCM, Lalai RA, Taveras MO, Zhang S, Adams TE, Terry LV, Turpin-Nolan SM, de Vries MR, Giera M, Rose-John S, Zelcer N, de Boer JF, de Aguiar Vallim TQ, Febbraio MA, Rensen PCN, Schonke M. The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice. Sci Adv. 2025 Oct 24;11(43):eadx3794. doi: 10.1126/sciadv.adx3794. Epub 2025 Oct 24.
- Derived from this study: PubMed 40318255Mohammadnia N, van Broekhoven A, Bax WA, Eikelboom JW, Mosterd A, Fiolet ATL, Tijssen JGP, Thompson PL, de Kleijn DPV, Tsimikas S, Cornel JH, Yeang C, El Messaoudi S. Interleukin-6 modifies Lipoprotein(a) and oxidized phospholipids associated cardiovascular disease risk in a secondary prevention cohort. Atherosclerosis. 2025 Jun;405:119211. doi: 10.1016/j.atherosclerosis.2025.119211. Epub 2025 Apr 26.
- Individual participant dataSharing planned: Yes. According to the Novo Nordisk disclosure commitment on novonordisk-trials.com
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Clinical Transparency (dept. 2834) study director
Novo Nordisk A/S
1,073 sites in 38 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 3 study testing Ziltivekimab B and Ziltivekimab C in people with Cardiovascular Risk and Chronic Kidney Disease, run by Novo Nordisk A/S at 1,073 sites in 38 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1,073 sites in United States, Japan, China, India, Germany and 33 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time to first occurrence of 3-point Major Adverse Cardiovascular Event (MACE), a composite endpoint consisting of: Cardiovascular (CV) death, non-fatal Myocardial Infarction (MI) and non-fatal stroke (time frame: From randomisation (month 0) to end-of-study (up to 48 months)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05021835, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Sep 2026.