Antibiotics Causing Adverse Effects in Therapeutic UseCIEDNCT05020418
De-Implementation of Inappropriate Antimicrobial Use After Cardiac Device Procedures
A study testing Chart Review in people with Antibiotics Causing Adverse Effects in Therapeutic Use, run by VA Office of Research and Development at 1 site in United States.
Trial summary
This project will use automated audit and feedback to improve compliance with antimicrobial prophylaxis guidelines for CIED procedures that we anticipate will translate into better outcomes for our patients. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Antibiotics Causing Adverse Effects in Therapeutic Use
- What is being tested?
- Chart Review
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 5,469 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Mar 2023to 1 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- This study is open to any adult VA patient with data about a cardiac device procedure performed in the electrophysiology laboratory entered into the national VA EHR.
Who cannot join
- None
Trial locations and contacts
1 site in 1 country.
United States1 site
VA Boston Healthcare System
Boston, Massachusetts, 02130
About this study
Official title: Promoting De-Implementation of Inappropriate Antimicrobial Use in Cardiac Device Procedures By Expanding Audit and Feedback
This project will use automated audit and feedback to improve compliance with antimicrobial prophylaxis guidelines for CIED procedures that we anticipate will translate into better outcomes for our patients. A multi-faceted implementation bundle to promote de-implementation of guideline discordant care will be tested at three intervention sites. Materials and tools will then be disseminated throughout the VA healthcare system if the intervention is found to be effective.
Read the detailed description
Aim I tests the hypothesis that a multi-faceted implementation/deimplementation bundle (I/D) of strategies that includes educational sessions with members of electrophysiology teams and locally-adapted monthly surveillance reports about guideline-concordant pre-procedural antimicrobial use and guideline-discordant post-procedural antimicrobial use, 90-day incidence of CIED infections, and 90-day incidence of C. difficile infections and 7-day incidence of AKI that will be delivered to local infectious diseases champions and shared with electrophysiology teams using blended facilitation will promote uptake of best practices and improve outcomes. This hypothesis incorporates learning/unlearning and fills a major gap caused by the dearth of rigorous de- implementation and de-adoption studies. Aim II tests the hypothesis that electronic health records (EHRs) and medical informatics have advanced to the point that it will be feasible, during the next four years, to establish an audit and feedback surveillance system that can be scaled and disseminated widely across the VA.
This study will use mixed qualitative and quantitative methods to address the study aims. This will include interviews with key stakeholders and quantitative measurement of quality metrics (e.g., pre-and post-procedure antimicrobial use) and outcomes (e.g., cardiac device infections, acute kidney injuries, C. difficile infections).
All patients receiving a cardiac device implantation within the VA healthcare system during the study period may be potentially included. Medical records previously reviewed and accessed may also be included for validation, testing, and optimization of electronic algorithms. In addition to the VA patients who will participate, key stakeholders for infection prevention in the cardiac device laboratory (e.g., providers, nurses, electrophysiology laboratory staff) will also participate in interviews. Active implementation will occur at 3 VA sites receiving the high-intensity I/D bundle. 8 matched control sites will be selected for comparison.
High quality studies establish that prolonged prophylaxis has no beneficial impact on CIED-related infection rates but worsens outcomes and leads to preventable deaths. Despite guidelines specifically recommending against prolonged prophylaxis, this practice is common in cardiac electrophysiology laboratories, including VA and non-VA hospitals. At the same time, antimicrobial resistance and overuse represent critical threats to the health of the population. This intersection - inappropriate prescribing and a critical need to improve use-- creates an urgent need for research into methods to promote adoption of best antimicrobial use and de-implementation of ineffective and harmful prescribing. IT-based solutions for improving antimicrobial use, including antimicrobial prophylaxis, is a quality-improvement strategy endorsed by The Joint Commission. This project will advance this concept and couple learning/unlearning processes to promote uptake of best practices. If effective, this model can be replicated in other settings of care to improve antimicrobial use.
- Being tested
- Chart Review
- Keywords
- cardiac devices, antimicrobial use, chart review, learning/unlearning, de-implementation, de-adoption, Hybrid III implementation trial, antimicrobial stewardship, peri-operative antimicrobial use, peri-procedural antimicrobial use, peri-procedural infection control, stepped-wedge
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Chart ReviewOther
Intervention sites will receive a multi-faceted implementation intervention, which will include external and internal blended facilitation, education materials for providers and patients, and audit and feedback about practices and outcomes with benchmarking to non-intervention sites.
| Study group | Role | What they receive |
|---|---|---|
| Cardiac Device Cohort | Experimental | The Intervention Arm is receipt of the high-intensity implementation/deimplementation (I/D) bundle (3 sites). Control sites will be matched based on similar practices but not receive the high-intensity I/D bundle. Receives: Other: Chart Review |
What is being measured
The primary outcome is the main question the study is designed to answer.
cardiac device infection
Incidence of cardiac device infections
Measured: 90 days
C. difficile infections
Incidence of C. difficile infections
Measured: 90 days
Acute Kidney Injury (AKI)
Incidence of AKI
Measured: 7 days
Pre-procedure Antimicrobial Use
Proportion of cases with guideline-concordant pre-procedure antimicrobial use defined as appropriate antimicrobials administered within 1 hour prior to incision.
Measured: 1 day
Post-procedure Antimicrobial Use
Proportion of cases with guideline-concordant post-procedure antimicrobial use defined as antibiotics administered for prevention of cardiac device infection (not for pre-existing infection) lasting for greater than 24 hours following the procedure.
Measured: 14 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Aug 2021
- Study start1 Mar 2023
- Primary completion1 Oct 2025
- Study completion1 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (16)Papers the sponsor has linked to this study.
- Other trials for Antibiotics Causing Adverse Effects in Therapeutic UseStudies of the same condition, open and under way.
- More trials run by VA Office of Research and DevelopmentThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Cardiac device procedures performed within the national VA healthcare system during the period from Fiscal Year (FY) 16-24 will be identified using a list of relevant Current Procedural Terminology (CPT) codes. Based on our preliminary results, we anticipate that the VA Corporate Data Warehouse (CDW) EP Procedures Cohort (electronic surveillance cohort) will include approximately 100,000 cardiac device cases. Because this cohort is based in CDW, once a Veteran undergoing a device procedure is identified using CPT codes, the orders, procedures, and consults that occurred during the 90-day window following the procedure can be extracted from the VA Electronic Health Record (EHR) In addition to the full cohort, the implementation bundle will be tested at the three high-volume intervention sites (\~1500 cases per year). Roll out of the interventions will occur in a stepped manner, such that pre- and post- intervention data will be collected at all sites.
- Masking
- None (open label)
- Enrolment
- 5,469 participants (actual)
Sponsor and investigators
- Lead sponsor
- VA Office of Research and Development
- Sponsor type
- US federal agency
- Collaborators
- VA Boston Healthcare System
- Responsible party
- Sponsor
- Investigators
- Westyn Branch-Elliman, MD, Principal investigator, VA Boston Healthcare System
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05020418
- Sponsor's protocol ID
- IIR 20-076
- Other IDs
- IRB 1585926
- Acronym
- CIED
- Status last verified
- Jul 2026
- First submitted
- 18 Aug 2021
- Last updated
- 21 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: A de-identified, anonymized dataset will be created and shared upon request and executing a Data Use Agreement (DUA) following VA research regulations, current guidance can be found in Veteran's Health Administration (VHA) Directive 1080.01(1) last updated March 2021.
Publications
Branch-Elliman W, Lamkin R, Shin M, Mull HJ, Epshtein I, Golenbock S, Schweizer ML, Colborn K, Rove J, Strymish JM, Drekonja D, Rodriguez-Barradas MC, Xu TH, Elwy AR. Promoting de-implementation of inappropriate antimicrobial use in cardiac device procedures by expanding audit and feedback: protocol for hybrid III type effectiveness/implementation quasi-experimental study. Implement Sci. 2022 Jan 29;17(1):12. doi: 10.1186/s13012-022-01186-8.
PubMed 35093104La J, Fillmore NR, Do NV, Brophy M, Monach PA, Branch-Elliman W. Factors associated with the speed and scope of diffusion of COVID-19 therapeutics in a nationwide healthcare setting: a mixed-methods investigation. Health Res Policy Syst. 2022 Dec 14;20(1):134. doi: 10.1186/s12961-022-00935-x.
PubMed 36517793Shenoy ES, Branch-Elliman W. Automating surveillance for healthcare-associated infections: Rationale and current realities (Part I/III). Antimicrob Steward Healthc Epidemiol. 2023 Feb 10;3(1):e25. doi: 10.1017/ash.2022.312. eCollection 2023.
PubMed 36865706Branch-Elliman W, Sundermann AJ, Wiens J, Shenoy ES. The future of automated infection detection: Innovation to transform practice (Part III/III). Antimicrob Steward Healthc Epidemiol. 2023 Feb 10;3(1):e26. doi: 10.1017/ash.2022.333. eCollection 2023.
PubMed 36865708Branch-Elliman W, Sundermann AJ, Wiens J, Shenoy ES. Leveraging electronic data to expand infection detection beyond traditional settings and definitions (Part II/III). Antimicrob Steward Healthc Epidemiol. 2023 Feb 10;3(1):e27. doi: 10.1017/ash.2022.342. eCollection 2023.
PubMed 36865709Reyes Dassum S, Mull HJ, Golenbock S, Lamkin RP, Epshtein I, Shin MH, Strymish JM, Blumenthal KG, Colborn K, Branch-Elliman W. A Novel Informatics Tool to Detect Periprocedural Antibiotic Allergy Adverse Events for Near Real-time Surveillance to Support Audit and Feedback. JAMA Netw Open. 2023 May 1;6(5):e2313964. doi: 10.1001/jamanetworkopen.2023.13964.
PubMed 37195660Branch-Elliman W, Elwy AR, Chambers DA. Embracing dynamic public health policy impacts in infectious diseases responses: leveraging implementation science to improve practice. Front Public Health. 2023 Aug 17;11:1207679. doi: 10.3389/fpubh.2023.1207679. eCollection 2023.
PubMed 37663826Young S, Mull HJ, Golenbock S, Stolzmann K, Shin M, Lamkin RP, Linsenmeyer KD, Epshtein I, Kalver E, Strymish JM, Branch-Elliman W. Factors associated with uptake of guideline-recommended cardiovascular implantable electronic device management: a nationwide, retrospective cohort study. Antimicrob Steward Healthc Epidemiol. 2023 Oct 25;3(1):e187. doi: 10.1017/ash.2023.422. eCollection 2023.
PubMed 38028909Al Lawati H, Shin M, Lamkin R, Thompson T, Epshtein I, Mull H, Basnet Thapa D, Drekonja D, Rodriguez-Barradas MC, Xu TH, Gold H, Elwy AR, Strymish J, Branch-Elliman W. Engaging patients in antimicrobial stewardship: co-designed educational tool to improve periprocedural care through de-implementation of guideline-discordant antimicrobial use. Antimicrob Steward Healthc Epidemiol. 2023 Sep 28;3(1):e163. doi: 10.1017/ash.2023.420. eCollection 2023.
PubMed 38028930Al Lawati HJ, Harvey KL, Shin M, Mull H, Lamkin RP, Golenbock S, Basnet-Thapa D, Strymish JM, Lee M, Gold H, Bidwell Goetz M, Branch-Elliman W. Operationalizing an adverse event detection surveillance system to support antimicrobial stewardship activities: perceptions and insights from the SHEA research network. Infect Control Hosp Epidemiol. 2024 Dec;45(12):1468-1471. doi: 10.1017/ice.2024.141. Epub 2024 Oct 30.
PubMed 39473228Mull HJ, Golenbock SW, Basnet Thapa D, Shin MH, Harvey KL, Lamkin RP, Strymish J, Branch-Elliman W. Cardiac Implantable Device Infection Surveillance Algorithm. JAMA Netw Open. 2025 Jun 2;8(6):e2514079. doi: 10.1001/jamanetworkopen.2025.14079.
PubMed 40471582Harvey L, Abdulkerim H, Strymish J, Ryan SK, Boudreau J, Gifford A, Hyde J, Branch-Elliman W. Infectious Complications of Substance Use: A Retrospective Cohort Study of Hospitalized Veterans. Open Forum Infect Dis. 2025 May 17;12(6):ofaf301. doi: 10.1093/ofid/ofaf301. eCollection 2025 Jun.
PubMed 40476030Golenbock SW, Basnet D, Mull HJ, Lamkin R, Harvey K, Shin M, Strymish JM, Leatherman S, Ferguson R, Branch-Elliman W. Development of a feasible and portable electronic flag for near-real-time identification of renal replacement therapy in the Veterans Health Administration. Antimicrob Steward Healthc Epidemiol. 2025 Oct 23;5(1):e279. doi: 10.1017/ash.2025.10166. eCollection 2025.
PubMed 41180296Basnet D, Mull HJ, Morgan DJ, Golenbock SW, Lamkin RP, Strymish JM, Harvey K, Yuen K, Schweizer ML, Drekonja D, Rodriguez-Barradas MC, Branch-Elliman W. Leveraging a large language model to support expansion of surveillance activities to include cardiovascular implantable device infections in a large, integrated national healthcare system. Infect Control Hosp Epidemiol. 2026 Jan 23;47(4):1-6. doi: 10.1017/ice.2025.10384. Online ahead of print.
PubMed 41572724Basnet D, Golenbock S, Strymish JM, Mull HJ, Lamkin RP, Shin M, Harvey K, Karchmer AW, Branch-Elliman W. Bloodstream Infections Among Veterans With Cardiac Implantable Electronic Devices: Source Identification and Intervention Strategies. Open Forum Infect Dis. 2026 Feb 23;13(2):ofag020. doi: 10.1093/ofid/ofag020. eCollection 2026 Feb.
PubMed 41737048
Study at a glance
From the registry record, last updated by the sponsor on 21 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Promoting De-Implementation of Inappropriate Antimicrobial Use in Cardiac Device Procedures By Expanding Audit and Feedback
- ClinicalTrials.gov ID
- NCT05020418
- Acronym / sponsor ID
- CIED / IIR 20-076
- Keywords
- cardiac devices, antimicrobial use, chart review, learning/unlearning, de-implementation, de-adoption, Hybrid III implementation trial, antimicrobial stewardship
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 5,469 participants (actual)
- Lead sponsor
- VA Office of Research and DevelopmentUS federal agency
- Collaborators
- VA Boston Healthcare System
- Study start
- 1 Mar 2023 (actual)
- Primary completion
- 1 Oct 2025 (actual)
- Study completion
- 1 Dec 2025 (actual)
- First posted
- 25 Aug 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This project will use automated audit and feedback to improve compliance with antimicrobial prophylaxis guidelines for CIED procedures that we anticipate will translate into better outcomes for our patients. A multi-faceted implementation bundle to promote de-implementation of guideline discordant care will be tested at three intervention sites. Materials and tools will then be disseminated throughout the VA healthcare system if the intervention is found to be effective.
Detailed description
Aim I tests the hypothesis that a multi-faceted implementation/deimplementation bundle (I/D) of strategies that includes educational sessions with members of electrophysiology teams and locally-adapted monthly surveillance reports about guideline-concordant pre-procedural antimicrobial use and guideline-discordant post-procedural antimicrobial use, 90-day incidence of CIED infections, and 90-day incidence of C. difficile infections and 7-day incidence of AKI that will be delivered to local infectious diseases champions and shared with electrophysiology teams using blended facilitation will promote uptake of best practices and improve outcomes. This hypothesis incorporates learning/unlearning and fills a major gap caused by the dearth of rigorous de- implementation and de-adoption studies. Aim II tests the hypothesis that electronic health records (EHRs) and medical informatics have advanced to the point that it will be feasible, during the next four years, to establish an audit and feedback surveillance system that can be scaled and disseminated widely across the VA.
This study will use mixed qualitative and quantitative methods to address the study aims. This will include interviews with key stakeholders and quantitative measurement of quality metrics (e.g., pre-and post-procedure antimicrobial use) and outcomes (e.g., cardiac device infections, acute kidney injuries, C. difficile infections).
All patients receiving a cardiac device implantation within the VA healthcare system during the study period may be potentially included. Medical records previously reviewed and accessed may also be included for validation, testing, and optimization of electronic algorithms. In addition to the VA patients who will participate, key stakeholders for infection prevention in the cardiac device laboratory (e.g., providers, nurses, electrophysiology laboratory staff) will also participate in interviews. Active implementation will occur at 3 VA sites receiving the high-intensity I/D bundle. 8 matched control sites will be selected for comparison.
High quality studies establish that prolonged prophylaxis has no beneficial impact on CIED-related infection rates but worsens outcomes and leads to preventable deaths. Despite guidelines specifically recommending against prolonged prophylaxis, this practice is common in cardiac electrophysiology laboratories, including VA and non-VA hospitals. At the same time, antimicrobial resistance and overuse represent critical threats to the health of the population. This intersection - inappropriate prescribing and a critical need to improve use-- creates an urgent need for research into methods to promote adoption of best antimicrobial use and de-implementation of ineffective and harmful prescribing. IT-based solutions for improving antimicrobial use, including antimicrobial prophylaxis, is a quality-improvement strategy endorsed by The Joint Commission. This project will advance this concept and couple learning/unlearning processes to promote uptake of best practices. If effective, this model can be replicated in other settings of care to improve antimicrobial use.
Study design
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Cardiac device procedures performed within the national VA healthcare system during the period from Fiscal Year (FY) 16-24 will be identified using a list of relevant Current Procedural Terminology (CPT) codes. Based on our preliminary results, we anticipate that the VA Corporate Data Warehouse (CDW) EP Procedures Cohort (electronic surveillance cohort) will include approximately 100,000 cardiac device cases. Because this cohort is based in CDW, once a Veteran undergoing a device procedure is identified using CPT codes, the orders, procedures, and consults that occurred during the 90-day window following the procedure can be extracted from the VA Electronic Health Record (EHR) In addition to the full cohort, the implementation bundle will be tested at the three high-volume intervention sites (~1500 cases per year). Roll out of the interventions will occur in a stepped manner, such that pre- and post- intervention data will be collected at all sites.
| Arm | Type | Receives |
|---|---|---|
| Cardiac Device Cohort | Experimental | Other: Chart ReviewThe Intervention Arm is receipt of the high-intensity implementation/deimplementation (I/D) bundle (3 sites). Control sites will be matched based on similar practices but not receive the high-intensity I/D bundle. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- This study is open to any adult VA patient with data about a cardiac device procedure performed in the electrophysiology laboratory entered into the national VA EHR.
Key exclusion criteria (1 listed)
- None
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Chart ReviewIntervention sites will receive a multi-faceted implementation intervention, which will include external and internal blended facilitation, education materials for providers and patients, and audit and feedback about practices and outcomes with benchmarking to non-intervention sites. | Other | Cardiac Device Cohort |
Primary outcome
cardiac device infection
Time frame: 90 days
Incidence of cardiac device infections
C. difficile infections
Time frame: 90 days
Incidence of C. difficile infections
Acute Kidney Injury (AKI)
Time frame: 7 days
Incidence of AKI
Pre-procedure Antimicrobial Use
Time frame: 1 day
Proportion of cases with guideline-concordant pre-procedure antimicrobial use defined as appropriate antimicrobials administered within 1 hour prior to incision.
Post-procedure Antimicrobial Use
Time frame: 14 days
Proportion of cases with guideline-concordant post-procedure antimicrobial use defined as antibiotics administered for prevention of cardiac device infection (not for pre-existing infection) lasting for greater than 24 hours following the procedure.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Jul 2026.
- Background: PubMed 35093104Branch-Elliman W, Lamkin R, Shin M, Mull HJ, Epshtein I, Golenbock S, Schweizer ML, Colborn K, Rove J, Strymish JM, Drekonja D, Rodriguez-Barradas MC, Xu TH, Elwy AR. Promoting de-implementation of inappropriate antimicrobial use in cardiac device procedures by expanding audit and feedback: protocol for hybrid III type effectiveness/implementation quasi-experimental study. Implement Sci. 2022 Jan 29;17(1):12. doi: 10.1186/s13012-022-01186-8.
- Background: PubMed 36517793La J, Fillmore NR, Do NV, Brophy M, Monach PA, Branch-Elliman W. Factors associated with the speed and scope of diffusion of COVID-19 therapeutics in a nationwide healthcare setting: a mixed-methods investigation. Health Res Policy Syst. 2022 Dec 14;20(1):134. doi: 10.1186/s12961-022-00935-x.
- Background: PubMed 36865706Shenoy ES, Branch-Elliman W. Automating surveillance for healthcare-associated infections: Rationale and current realities (Part I/III). Antimicrob Steward Healthc Epidemiol. 2023 Feb 10;3(1):e25. doi: 10.1017/ash.2022.312. eCollection 2023.
- Background: PubMed 36865708Branch-Elliman W, Sundermann AJ, Wiens J, Shenoy ES. The future of automated infection detection: Innovation to transform practice (Part III/III). Antimicrob Steward Healthc Epidemiol. 2023 Feb 10;3(1):e26. doi: 10.1017/ash.2022.333. eCollection 2023.
- Background: PubMed 36865709Branch-Elliman W, Sundermann AJ, Wiens J, Shenoy ES. Leveraging electronic data to expand infection detection beyond traditional settings and definitions (Part II/III). Antimicrob Steward Healthc Epidemiol. 2023 Feb 10;3(1):e27. doi: 10.1017/ash.2022.342. eCollection 2023.
- Background: PubMed 37195660Reyes Dassum S, Mull HJ, Golenbock S, Lamkin RP, Epshtein I, Shin MH, Strymish JM, Blumenthal KG, Colborn K, Branch-Elliman W. A Novel Informatics Tool to Detect Periprocedural Antibiotic Allergy Adverse Events for Near Real-time Surveillance to Support Audit and Feedback. JAMA Netw Open. 2023 May 1;6(5):e2313964. doi: 10.1001/jamanetworkopen.2023.13964.
- Background: PubMed 37663826Branch-Elliman W, Elwy AR, Chambers DA. Embracing dynamic public health policy impacts in infectious diseases responses: leveraging implementation science to improve practice. Front Public Health. 2023 Aug 17;11:1207679. doi: 10.3389/fpubh.2023.1207679. eCollection 2023.
- Background: PubMed 38028909Young S, Mull HJ, Golenbock S, Stolzmann K, Shin M, Lamkin RP, Linsenmeyer KD, Epshtein I, Kalver E, Strymish JM, Branch-Elliman W. Factors associated with uptake of guideline-recommended cardiovascular implantable electronic device management: a nationwide, retrospective cohort study. Antimicrob Steward Healthc Epidemiol. 2023 Oct 25;3(1):e187. doi: 10.1017/ash.2023.422. eCollection 2023.
- Background: PubMed 38028930Al Lawati H, Shin M, Lamkin R, Thompson T, Epshtein I, Mull H, Basnet Thapa D, Drekonja D, Rodriguez-Barradas MC, Xu TH, Gold H, Elwy AR, Strymish J, Branch-Elliman W. Engaging patients in antimicrobial stewardship: co-designed educational tool to improve periprocedural care through de-implementation of guideline-discordant antimicrobial use. Antimicrob Steward Healthc Epidemiol. 2023 Sep 28;3(1):e163. doi: 10.1017/ash.2023.420. eCollection 2023.
- Background: PubMed 39473228Al Lawati HJ, Harvey KL, Shin M, Mull H, Lamkin RP, Golenbock S, Basnet-Thapa D, Strymish JM, Lee M, Gold H, Bidwell Goetz M, Branch-Elliman W. Operationalizing an adverse event detection surveillance system to support antimicrobial stewardship activities: perceptions and insights from the SHEA research network. Infect Control Hosp Epidemiol. 2024 Dec;45(12):1468-1471. doi: 10.1017/ice.2024.141. Epub 2024 Oct 30.
- Background: PubMed 40471582Mull HJ, Golenbock SW, Basnet Thapa D, Shin MH, Harvey KL, Lamkin RP, Strymish J, Branch-Elliman W. Cardiac Implantable Device Infection Surveillance Algorithm. JAMA Netw Open. 2025 Jun 2;8(6):e2514079. doi: 10.1001/jamanetworkopen.2025.14079.
- Background: PubMed 40476030Harvey L, Abdulkerim H, Strymish J, Ryan SK, Boudreau J, Gifford A, Hyde J, Branch-Elliman W. Infectious Complications of Substance Use: A Retrospective Cohort Study of Hospitalized Veterans. Open Forum Infect Dis. 2025 May 17;12(6):ofaf301. doi: 10.1093/ofid/ofaf301. eCollection 2025 Jun.
- Individual participant dataSharing planned: No. A de-identified, anonymized dataset will be created and shared upon request and executing a Data Use Agreement (DUA) following VA research regulations, current guidance can be found in Veteran's Health Administration (VHA) Directive 1080.01(1) last updated March 2021.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Westyn Branch-Elliman, MD principal investigator
VA Boston Healthcare System
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Chart Review in people with Antibiotics Causing Adverse Effects in Therapeutic Use, run by VA Office of Research and Development at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
cardiac device infection (time frame: 90 days). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05020418, which also lists 16 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Jul 2026.