Wrist GanglionNCT04932122
Outcomes After Dorsal Wrist Ganglia Excision With or Without PIN
A study testing Dorsal wrist ganglion alone (DWG) and DWG/PIN in people with Wrist Ganglion and Ganglion Cysts, run by Kenneth Taylor, M.D. at 2 sites in United States.
Trial summary
The purpose of this study is to determine if a statistical significance exists between outcomes of patients treated for dorsal wrist ganglion cyst with excision alone versus excision and the addition of a partial wrist denervation by resecting the common terminal sensory branch of the PIN (posterior interosseus… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Wrist Ganglion, Ganglion Cysts, Hand Ganglion
- What is being tested?
- Dorsal wrist ganglion alone (DWG) and DWG/PIN
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 3 participants
- Where
- 2 sitesUnited States
- Study dates
- 7 Aug 2023to 3 Feb 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Greater than or equal to 18 years of age
- Gender: male/female (non-pregnant)
- Diagnosis of symptomatic (pain and limited ability to perform activities of daily living) dorsal wrist ganglion cyst
- Subjects who have chosen surgical management for their ganglion cyst diagnosis
- Fluent in written and spoken English
- Subject is able to provide voluntary, written informed consent
- Subject, in the opinion of the clinical investigator, is able to understand the clinical investigation and is willing to perform all study procedures and follow-up visits
- Non-Prisoners
Who cannot join
- Less than 18 years of age
- Non-elective surgery for this diagnosis
- Chronic wrist instability of the operative extremity
- Comorbid neurologic maladies of the operative extremity
- Prior wrist surgery on either extremity
- Non-English speaking
Show all 9Show fewer
- Prisoners
- Pregnancy
- Cognitive Impairment
Trial locations and contacts
2 sites in 1 country.
United States2 sites
Penn State Health Medical Group - Camp Hill Specialties
Camp Hill, Pennsylvania, 17011
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033
About this study
Official title: Outcomes of Surgical Excision of Dorsal Wrist Ganglia With or Without Partial Wrist Denervation
The purpose of this study is to determine if a statistical significance exists between outcomes of patients treated for dorsal wrist ganglion cyst with excision alone versus excision and the addition of a partial wrist denervation by resecting the common terminal sensory branch of the PIN (posterior interosseus nerve). Our hypothesis is that addition of PIN improves outcome after dorsal wrist ganglion excision as indicated by post-operative pain, function, ability to perform activities of daily living, and physical exam findings.
Read the detailed description
The primary endpoint will be outcomes on subject surveys and questionnaires. Data will be collected pre- and post-operatively at 2 weeks, 12 weeks, 6 months, and one year. Four questionnaires will be used, including the Visual Analog Pain Score (VAS), Disabilities of the Arm, Shoulder, and Hand (QuickDASH) questionnaire, as well as the Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference (PI), and the PROMIS Pain Behavior (PB) questionnaires.
Secondary outcomes include physical examination consisting of pre- and post-operative pinch and grip strength testing, and active range of motion including wrist flexion and extension ulnar and radial deviation, and weight bearing extension. These will be performed at 2 weeks, 12 weeks, and 6 months post-operatively.
- Conditions
- Wrist Ganglion, Ganglion Cysts, Hand Ganglion, Denervation Atrophy
- Being tested
- Dorsal wrist ganglion alone (DWG), DWG/PIN
- Keywords
- ganglion cysts, dorsal wrist ganglia, neurectomy, denervation, posterior interosseous nerve
- Medical subject headings
- Ganglion Cysts
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Dorsal wrist ganglion alone (DWG)Procedure or surgery
Patients assigned to this arm will undergo dorsal wrist ganglion cyst excision alone.
DWG/PINProcedure or surgery
Patients assigned to this arm will undergo dorsal wrist ganglion excision and the addition of a partial wrist denervation by resecting the common terminal sensory branch of the posterior interosseus nerve (PIN)..
| Study group | Role | What they receive |
|---|---|---|
| Dorsal wrist ganglion alone (DWG) | Active comparator | Dorsal wrist ganglion excision alone Receives: Procedure: Dorsal wrist ganglion alone (DWG) |
| DWG with PIN | Active comparator | Dorsal wrist ganglion excision with posterior interosseus neurectomy (PIN) Receives: Procedure: DWG/PIN |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain measured with the Visual Analog Pain Scale (VAS)
Self-report measurement that assesses a person's perceived level of pain
Measured: Preop to One Year Post-Op
Physical Function measured with the Disabilities of the Arm, Shoulder and Hand questionnaire (QuickDASH)
11-Item questionnaire that measures physical function and symptoms in people with musculoskeletal disorders of the upper limb
Measured: Preop to One Year Post-Op
Pain interference measured with the Patient-Reported Outcomes Measurement Information (PROMIS) Pain Interference instrument
This instrument measures the self-reported consequences of pain on relevant aspects of one's life and may include the extent to which pain hinders engagement with social, cognitive, emotional, physical, and recreational activities.
Measured: Preop to One Year Post-Op
Pain behavior measured with the Patient-Reported Outcomes Measurement Information (PROMIS) Pain Behavior instrument
This instrument measures self-reported external manifestations of pain: behaviors that typically indicate to others that an individual is experiencing pain.
Measured: Preop to One Year Post-Op
Secondary outcomes (9)
Change in strength utilizing hand grip measurements
This measurement provides information about muscle strength health in the hand and forearms. The average of three measurements is taken using a hand-held dynamometer
Measured: Preop to 6 Months Post-Op
Change in strength utilizing finger lateral pinch measurements
This measurement provides information about the functional strength of one's pinching action of the hand using a mechanical pinch gauge. The average of three measurements will be taken at each time frame.
Measured: Preop to 6 Months Post-Op
Change in strength utilizing finger tip pinch measurements
This measurement provides information about the functional strength of one's pinching action of the hand using a mechanical pinch gauge. The average of three measurements will be taken at each time frame.
Measured: Preop to 6 Months Post-Op
Change in strength utilizing finger three-point pinch measurements
This measurement provides information about the functional strength of one's pinching action of the hand using a mechanical pinch gauge. The average of three measurements will be taken at each time frame.
Measured: Preop to 6 Months Post-Op
Change in wrist flexion
This measurement indicates the range of motion of the wrist utilizing a goniometer
Measured: Preop to 6 Months Post-Op
Change in wrist extension
This measurement indicates the range of motion of the wrist utilizing a goniometer
Measured: Preop to 6 Months Post-Op
Change in wrist weight bearing extension
This measurement indicates the range of motion of the wrist utilizing a goniometer
Measured: Preop to 6 Months Post-Op
Change in wrist ulnar deviation
This measurement indicates the range of motion of the wrist from side to side. This movement flexes the hand toward the ulnar bone in the arm. This is measured with a goniometer.
Measured: Preop to 6 Months Post-Op
Change in wrist radial deviation
This measurement indicates the range of motion of the wrist from side to side. This movement flexes the hand toward the radial bone in the arm. This is measured with a goniometer.
Measured: Preop to 6 Months Post-Op
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Jun 2021
- Study start7 Aug 2023
- Primary completion3 Feb 2026
- Study completion3 Feb 2026
Why it stopped: Study recruitment stopped due to recruitment problems
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (18)Papers the sponsor has linked to this study.
- Other trials for Wrist GanglionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 3 participants (actual)
Sponsor and investigators
- Lead sponsor
- Kenneth Taylor, M.D.
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Kenneth Taylor, M.D., Milton S. Hershey Medical Center
- Investigators
- Kenneth Taylor, MD, Principal investigator, Penn State Health Milton S Hershey Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04932122
- Sponsor's protocol ID
- STUDY00016888
- Status last verified
- Feb 2026
- First submitted
- 24 May 2021
- Last updated
- 11 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Ho PC, Griffiths J, Lo WN, Yen CH, Hung LK. Current treatment of ganglion of the wrist. Hand Surg. 2001 Jul;6(1):49-58. doi: 10.1142/s0218810401000540.
PubMed 11677666Thornburg LE. Ganglions of the hand and wrist. J Am Acad Orthop Surg. 1999 Jul-Aug;7(4):231-8. doi: 10.5435/00124635-199907000-00003.
PubMed 10434077Angelides AC, Wallace PF. The dorsal ganglion of the wrist: its pathogenesis, gross and microscopic anatomy, and surgical treatment. J Hand Surg Am. 1976 Nov;1(3):228-35. doi: 10.1016/s0363-5023(76)80042-1.
PubMed 1018091Clay NR, Clement DA. The treatment of dorsal wrist ganglia by radical excision. J Hand Surg Br. 1988 May;13(2):187-91. doi: 10.1016/0266-7681_88_90135-0.
PubMed 3385297Dellon AL, Seif SS. Anatomic dissections relating the posterior interosseous nerve to the carpus, and the etiology of dorsal wrist ganglion pain. J Hand Surg Am. 1978 Jul;3(4):326-32. doi: 10.1016/s0363-5023(78)80032-x.
PubMed 681715Carr D, Davis P. Distal posterior interosseous nerve syndrome. J Hand Surg Am. 1985 Nov;10(6 Pt 1):873-8. doi: 10.1016/s0363-5023(85)80165-9.
PubMed 4078272Dellon AL. Partial dorsal wrist denervation: resection of the distal posterior interosseous nerve. J Hand Surg Am. 1985 Jul;10(4):527-33. doi: 10.1016/s0363-5023(85)80077-0.
PubMed 4020064Faithfull DK, Seeto BG. The simple wrist ganglion--more than a minor surgical procedure? Hand Surg. 2000 Dec;5(2):139-43. doi: 10.1142/s0218810400000235.
PubMed 11301508Fukumoto K, Kojima T, Kinoshita Y, Koda M. An anatomic study of the innervation of the wrist joint and Wilhelm's technique for denervation. J Hand Surg Am. 1993 May;18(3):484-9. doi: 10.1016/0363-5023(93)90096-L.
PubMed 8515020Hudak PL, Amadio PC, Bombardier C. Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG). Am J Ind Med. 1996 Jun;29(6):602-8. doi: 10.1002/(SICI)1097-0274(199606)29:63.0.CO;2-L.
PubMed 8773720Chung KC, Pillsbury MS, Walters MR, Hayward RA. Reliability and validity testing of the Michigan Hand Outcomes Questionnaire. J Hand Surg Am. 1998 Jul;23(4):575-87. doi: 10.1016/S0363-5023(98)80042-7.
PubMed 9708370Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992 Jun;30(6):473-83.
PubMed 1593914Szabo RM. Outcomes assessment in hand surgery: when are they meaningful? J Hand Surg Am. 2001 Nov;26(6):993-1002. doi: 10.1053/jhsu.2001.29487.
PubMed 11721242Gundes H, Cirpici Y, Sarlak A, Muezzinoglu S. Prognosis of wrist ganglion operations. Acta Orthop Belg. 2000 Oct;66(4):363-7.
PubMed 11103488BUTLER ED, HAMILL JP, SEIPEL RS, DE LORIMIER AA. Tumors of the hand. A ten-year survey and report of 437 cases. Am J Surg. 1960 Aug;100:293-302. doi: 10.1016/0002-9610(60)90302-0. No abstract available.
PubMed 13806476
Study at a glance
From the registry record, last updated by the sponsor on 11 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Outcomes of Surgical Excision of Dorsal Wrist Ganglia With or Without Partial Wrist Denervation
- ClinicalTrials.gov ID
- NCT04932122
- Acronym / sponsor ID
- STUDY00016888
- Conditions
- Wrist Ganglion, Ganglion Cysts, Hand Ganglion, Denervation Atrophy
- Keywords
- ganglion cysts, dorsal wrist ganglia, neurectomy, denervation, posterior interosseous nerve
- Study type
- Interventional
- Recruitment status
- TerminatedReason stopped: Study recruitment stopped due to recruitment problems
- Enrolment
- 3 participants (actual)
- Lead sponsor
- Kenneth Taylor, M.D.University, hospital or other
- Study start
- 7 Aug 2023 (actual)
- Primary completion
- 3 Feb 2026 (actual)
- Study completion
- 3 Feb 2026 (actual)
- First posted
- 18 Jun 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to determine if a statistical significance exists between outcomes of patients treated for dorsal wrist ganglion cyst with excision alone versus excision and the addition of a partial wrist denervation by resecting the common terminal sensory branch of the PIN (posterior interosseus nerve). Our hypothesis is that addition of PIN improves outcome after dorsal wrist ganglion excision as indicated by post-operative pain, function, ability to perform activities of daily living, and physical exam findings.
Detailed description
The primary endpoint will be outcomes on subject surveys and questionnaires. Data will be collected pre- and post-operatively at 2 weeks, 12 weeks, 6 months, and one year. Four questionnaires will be used, including the Visual Analog Pain Score (VAS), Disabilities of the Arm, Shoulder, and Hand (QuickDASH) questionnaire, as well as the Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference (PI), and the PROMIS Pain Behavior (PB) questionnaires.
Secondary outcomes include physical examination consisting of pre- and post-operative pinch and grip strength testing, and active range of motion including wrist flexion and extension ulnar and radial deviation, and weight bearing extension. These will be performed at 2 weeks, 12 weeks, and 6 months post-operatively.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Dorsal wrist ganglion alone (DWG) | Active comparator | Procedure: Dorsal wrist ganglion alone (DWG)Dorsal wrist ganglion excision alone |
| DWG with PIN | Active comparator | Procedure: DWG/PINDorsal wrist ganglion excision with posterior interosseus neurectomy (PIN) |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Greater than or equal to 18 years of age
- Gender: male/female (non-pregnant)
- Diagnosis of symptomatic (pain and limited ability to perform activities of daily living) dorsal wrist ganglion cyst
- Subjects who have chosen surgical management for their ganglion cyst diagnosis
- Fluent in written and spoken English
Key exclusion criteria (9 listed)
- Less than 18 years of age
- Non-elective surgery for this diagnosis
- Chronic wrist instability of the operative extremity
- Comorbid neurologic maladies of the operative extremity
- Prior wrist surgery on either extremity
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Dorsal wrist ganglion alone (DWG)Patients assigned to this arm will undergo dorsal wrist ganglion cyst excision alone. | Procedure or surgery | Dorsal wrist ganglion alone (DWG) |
| DWG/PINPatients assigned to this arm will undergo dorsal wrist ganglion excision and the addition of a partial wrist denervation by resecting the common terminal sensory branch of the posterior interosseus nerve (PIN).. | Procedure or surgery | DWG with PIN |
Primary outcome
Pain measured with the Visual Analog Pain Scale (VAS)
Time frame: Preop to One Year Post-Op
Self-report measurement that assesses a person's perceived level of pain
Physical Function measured with the Disabilities of the Arm, Shoulder and Hand questionnaire (QuickDASH)
Time frame: Preop to One Year Post-Op
11-Item questionnaire that measures physical function and symptoms in people with musculoskeletal disorders of the upper limb
Pain interference measured with the Patient-Reported Outcomes Measurement Information (PROMIS) Pain Interference instrument
Time frame: Preop to One Year Post-Op
This instrument measures the self-reported consequences of pain on relevant aspects of one's life and may include the extent to which pain hinders engagement with social, cognitive, emotional, physical, and recreational activities.
Pain behavior measured with the Patient-Reported Outcomes Measurement Information (PROMIS) Pain Behavior instrument
Time frame: Preop to One Year Post-Op
This instrument measures self-reported external manifestations of pain: behaviors that typically indicate to others that an individual is experiencing pain.
9 secondary outcomes
Change in strength utilizing hand grip measurements
Time frame: Preop to 6 Months Post-Op
Change in strength utilizing finger lateral pinch measurements
Time frame: Preop to 6 Months Post-Op
Change in strength utilizing finger tip pinch measurements
Time frame: Preop to 6 Months Post-Op
Change in strength utilizing finger three-point pinch measurements
Time frame: Preop to 6 Months Post-Op
Change in wrist flexion
Time frame: Preop to 6 Months Post-Op
Change in wrist extension
Time frame: Preop to 6 Months Post-Op
Change in wrist weight bearing extension
Time frame: Preop to 6 Months Post-Op
Change in wrist ulnar deviation
Time frame: Preop to 6 Months Post-Op
Change in wrist radial deviation
Time frame: Preop to 6 Months Post-Op
Results and safety
The study was stopped early (reason given: Study recruitment stopped due to recruitment problems). Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Feb 2026.
- Background: PubMed 11677666Ho PC, Griffiths J, Lo WN, Yen CH, Hung LK. Current treatment of ganglion of the wrist. Hand Surg. 2001 Jul;6(1):49-58. doi: 10.1142/s0218810401000540.
- Background: PubMed 10434077Thornburg LE. Ganglions of the hand and wrist. J Am Acad Orthop Surg. 1999 Jul-Aug;7(4):231-8. doi: 10.5435/00124635-199907000-00003.
- Background: PubMed 1018091Angelides AC, Wallace PF. The dorsal ganglion of the wrist: its pathogenesis, gross and microscopic anatomy, and surgical treatment. J Hand Surg Am. 1976 Nov;1(3):228-35. doi: 10.1016/s0363-5023(76)80042-1.
- Background: PubMed 3385297Clay NR, Clement DA. The treatment of dorsal wrist ganglia by radical excision. J Hand Surg Br. 1988 May;13(2):187-91. doi: 10.1016/0266-7681_88_90135-0.
- Background: PubMed 681715Dellon AL, Seif SS. Anatomic dissections relating the posterior interosseous nerve to the carpus, and the etiology of dorsal wrist ganglion pain. J Hand Surg Am. 1978 Jul;3(4):326-32. doi: 10.1016/s0363-5023(78)80032-x.
- Background: PubMed 4078272Carr D, Davis P. Distal posterior interosseous nerve syndrome. J Hand Surg Am. 1985 Nov;10(6 Pt 1):873-8. doi: 10.1016/s0363-5023(85)80165-9.
- Background: PubMed 4020064Dellon AL. Partial dorsal wrist denervation: resection of the distal posterior interosseous nerve. J Hand Surg Am. 1985 Jul;10(4):527-33. doi: 10.1016/s0363-5023(85)80077-0.
- Background: PubMed 11301508Faithfull DK, Seeto BG. The simple wrist ganglion--more than a minor surgical procedure? Hand Surg. 2000 Dec;5(2):139-43. doi: 10.1142/s0218810400000235.
- Background: PubMed 8515020Fukumoto K, Kojima T, Kinoshita Y, Koda M. An anatomic study of the innervation of the wrist joint and Wilhelm's technique for denervation. J Hand Surg Am. 1993 May;18(3):484-9. doi: 10.1016/0363-5023(93)90096-L.
- Background: PubMed 8773720Hudak PL, Amadio PC, Bombardier C. Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG). Am J Ind Med. 1996 Jun;29(6):602-8. doi: 10.1002/(SICI)1097-0274(199606)29:63.0.CO;2-L.
- Background: PubMed 9708370Chung KC, Pillsbury MS, Walters MR, Hayward RA. Reliability and validity testing of the Michigan Hand Outcomes Questionnaire. J Hand Surg Am. 1998 Jul;23(4):575-87. doi: 10.1016/S0363-5023(98)80042-7.
- Background: PubMed 1593914Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992 Jun;30(6):473-83.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Kenneth Taylor, MD principal investigator
Penn State Health Milton S Hershey Medical Center
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Dorsal wrist ganglion alone (DWG) and DWG/PIN in people with Wrist Ganglion and Ganglion Cysts, run by Kenneth Taylor, M.D. at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 11 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was stopped early (reason given: Study recruitment stopped due to recruitment problems). Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain measured with the Visual Analog Pain Scale (VAS) (time frame: Preop to One Year Post-Op). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04932122, which also lists 18 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Feb 2026.