Middle Cerebral Artery AneurysmNCT04927520
Prospective, Multicenter Cohort Study on the Safety and Efficacy of Treatment for Middle Cerebral Artery Aneurysms
An observational study of Middle Cerebral Artery Aneurysm, run by Second Affiliated Hospital, Zhejiang University, School of Medicine at 1 site in China.
Trial summary
Intracranial aneurysm is one of the most common cerebrovascular diseases, with a prevalence of about 3.2%. With the aging of the population and the further popularization of MRA and other examination methods, the prevalence of intracranial aneurysm will further increase. Read more about this study
- Who is it for?
- Ages 14 years and older
- Conditions the study is for
- Middle Cerebral Artery Aneurysm
- How many people
- 360 participants
- Where
- 1 siteChina
- Study dates
- 5 Jun 2021to 31 Dec 2024
- How long will I take part?
- 3 Months
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 14 years and older
- All sexes
- Child, Adult, Older adult
Study population: Patients diagnosed unruptured middle artery aneurysm and treated with coil embolization or endovascular therapy
Who may be able to join
- At least 1 middle cerebral artery aneurysm confirmed by imaging (CTA/MRA/DSA);
- Accept endovascular intervention or middle cerebral artery aneurysm clip craniotomy, regardless of whether there is a clinical symptoms;
- Multiple aneurysms, whether usual treatment, but it requires the treatment time interval to > 6 months;
- The subjects currently has independent life ability, namely the mRS score 3 points or less;
- The patient or family agreed to sign a consent form.
Who cannot join
- Patients with other intracranial vascular malformations, such as AVM and AVF;
- Fusiform, traumatic, bacterial or dissecting aneurysm;
- Ruptured middle cerebral artery aneurysm associated with intracranial hematoma;
- Intracranial or other parts of the patients with malignant tumors;
- General condition is bad, is expected to survival time less than 1 year or poor body condition, can't tolerate anesthesia or aneurysm surgery patients;
- Involved with other intracranial aneurysm patients clinical research;
- A hospital surgery clip or endovascular treatment of patients at the same time;
- Refused to follow-up of patients.
Trial locations and contacts
1 site in 1 country.
China1 site, 1 recruiting
- Recruiting
the Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310009
Qian Cong, 13588449124, congqian@zju.edu.cn
About this study
Official title: Safety and Efficacy of Treatment for Middle Cerebral Artery Aneurysms: a Prospective and Multicenter Trial
Intracranial aneurysm is one of the most common cerebrovascular diseases, with a prevalence of about 3.2%. With the aging of the population and the further popularization of MRA and other examination methods, the prevalence of intracranial aneurysm will further increase. Rupture of intracranial aneurysm is an important cause of death and severe disability in patients. The annual rate of rupture of intracranial aneurysm is about 1%, and the size of aneurysm, the location of aneurysm in the posterior circulation, and the history of subarachnoid hemorrhage on the aneurysm wall are the risk factors for aneurysm rupture. Phases are currently recognized tools for assessing the risk of aneurysm rupture, which can provide important guidance for neurosurgeons and patients to decide whether to actively intervene. In the last century, for patients with intracranial aneurysm with high risk of rupture, craniotomy and clipping for intracranial aneurysm was the gold standard for treatment.
However, with the rapid development of embolization technology and materials in the past 20 years, the application of endovascular embolization for intracranial aneurysms has been more and more widely, especially after several large prospective studies such as ISAT and ISUIA, endovascular embolization has more advantages over craniotomy clipping.Whereas, it is still very popular to adopt craniotomy clipping for middle cerebral artery aneurysms, the main reasons for which are relative superficial location, wider aneurysm neck, smaller parent artery and more branching vessels, etc., which make early endovascular embolization treatment not advantageous. With the maturity of stent-assisted embolization technology in recent years, the use of a new generation of stents, and the improvement of perioperative anti-platelet strategies, endovascular embolization has achieved good results in the treatment of middle artery aneurysms. However, these studies were retrospective, single-center studies, subject to a variety of confounding factors, and the reliability of the results is limited.
Read more
Therefore, it will be of great clinical significance to carry out a prospective, multi-center clinical study on the treatment strategy of middle cerebral artery aneurysms.
Patients with unruptured middle cerebral artery aneurysms who had been diagnosed with at least one imaging （CTA/MRA/DSA）were enrolled. The treatment including endovascular embolization and craniotomy clipping was determined according to routine management in the center. After receiving informed consent from the patients, the safety and effectiveness data were obtained to verify whether endovascular embolization was safe and effective. Through further follow-up and data analysis, protective factors and risk factors for the treatment of middle cerebral artery aneurysms were investigated. Through well-designed clinical studies, safer and more effective treatment methods can be found, and potential factors leading to perioperative complications can be found, ultimately improving the prognosis of patients with middle cerebral artery aneurysms.
Read the detailed description
- Data collection and management A unified and open public health platform will be established, and data will be centrally recorded in each central unit for verification by inspectors. An open network data platform for intracranial aneurysm research was established by the management personnel of different qualification levels. In order to ensure the advancement and sustainable development of the data platform construction, a public research platform for intracranial aneurysms shared in the province was built by using the keywords and retrieval items commonly used in China. After researcher training and standardized study of the scheme, the formal trial was started. A team of experts will be selected to form an inspection team, which will initiate visits to each organization and conduct the first inspection visit as soon as possible after screening the first subject. Regular monitoring visits are required until the end of the experiment. All the data were collected according to the electronic medical record (CRF) form, and then the aneurysm data (EDC) was managed according to the CRF form, and the accuracy and rigor of the data were checked in time. This study establishes a management committee, including clinical experts, evidence-based medicine experts, and CRO clinical study supervisors, who are responsible for project design, task formulation, supervision of project implementation, data analysis and formulation of standards and guidelines. The central laboratory and imaging interpretation center were established to carry out unified standard central storage for clinical specimens. The unified image and laboratory technology platform can be used for the image examination and post-processing technology in the project. Uniform standard interpretation of imaging data was carried out. A unified, standardized and efficient transmission mechanism for clinical specimens, data and data in each center was established. Establish a data management committee, set up a network data platform and be responsible for the construction and maintenance of the database, conduct real-time supervision on the quality of the input data, ensure the safety, integrity and accuracy of the data, establish and organize the implementation of the platform or offline dual-channel error correction and reminder mechanism. Set and manage the rights of all project participants on the data platform, monitor and record the data entry, modification and retrieval, set and manage the data publication of the open platform. Contact and consult statistical experts to conduct periodic analysis of data results and generate research reports. Relying on professional CRO company, in the implementation process for the implementation of the progress and quality of the implementation of random inspection supervision. At the same time, set up a data regular self-check mechanism. Establish a mechanism for regular training and evaluation of research participants. During the research progress, regular project coordination meetings were held to timely coordinate and solve problems in the process of the project.
- Sample size Sample size was calculated according to a calculation formula (α=0.05, bilateral test, 80% assurance). According to the literature and the data of the center, the rate of MRS<2 at 3 months was 95% for patients with endovascular interventional, and was 85% for those with craniotomy and clipping. The number of samples needed for each group was calculated by the software PASS15 to be at least 141. Considering that the maximum shedding rate of 20% might occur during the clinical follow-up, 180 cases were needed for each group, and 360 subjects were finally decided to be included in the study.
- Statistical Methods Statistical analysis of planned primary and secondary study endpoints will be conducted in accordance with the intentionality treatment principle. Subgroup analysis According to the needs of the experiment, the subjects can be divided into different centers, male and female, and different age groups for corresponding subgroup analysis. Methods for processing lost data Statistical analysis did not follow the study protocol population definition and other statistical methods were used to deal with lost data (e.g. multiple interpolation).
- Ethical approval of clinical research projects The study plan was reviewed and approved by the Ethics Committee of the Second Affiliated Hospital of Zhejiang University School of Medicine. The study protocol was designed and implemented in accordance with the International Conference on Harmonization for Good Clinical Practice (ICH-GCP) guidelines. In line with the national ethical behavior requirements, applicable to local laws and regulations, in strict compliance with the World Medical Association (WMA) Declaration of Helsinki ethical provisions.
- Informed Consent Process Improve the relevant examinations, check the inclusion and exclusion criteria of patients, and send the detailed information of the study to patients or their legal clients. If the patients or legal clients agree to participate in the study, they need to sign two copies of informed consent. The original consent form should be kept in the patient's study folder and another copy given to the patient. Patients or legal clients have the right to terminate their participation in the study at any time, and their decision will be recorded in the patient's study record.
- confidentiality The investigators will take every step to respect the privacy of the participants in the study. Only data that does not contain identifying information will be entered into the central research database to ensure the privacy of participants. In the process of monitoring data quality and study protocol compliance, the data monitor will refer to the medical records of the subject's clinical center and record them on the patient information sheet. In the reporting data and results, all personal information and research center information will be hidden to protect the privacy of participants.
- Adverse events management Adverse events occurred in the process of adverse events refers to the study of the subjects has a harmful effect on the health of all events. Serious Adverse Event Category: Serious Adverse Event refers to any event that occurred during the course of the study that had a serious adverse effect on the health of the subjects. Include: cause the subject to be hospitalized, prolong the length of the subject's hospital stay, cause the subject to be disabled, cause the subject's neurological or physical dysfunction, cause the subject's offspring to be born with a deformity, endanger the subject's life, the subject's death or other events that have a serious adverse effect on the subject's health. Adverse events reported to process all kinds of adverse events: take timely measures to deal with, and recorded in a report on the case. Serious adverse event (SAE) : take timely measures to deal with, and recorded in a report on the case, the researchers decided to withdrawal or by drugs, immediately report ethics committee, the drug clinical trial institution and the sponsor, 24 hours, report to the national and provincial food and drug administration. SAE is required to report adverse events and proximate errors via the Intra-hospital Network Notification System.
- Conditions
- Middle Cerebral Artery Aneurysm
- Keywords
- Middle cerebral artery aneurysms, Clipping surgery, Coil embolization, Endovascular therapy, Unruptured aneurysm
- Medical subject headings
- Intracranial Aneurysm
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Endovascular therapy group | Unruptured middle cerebral artery aneurysms treated with coil embolization | |
| Clipping surgery group | Unruptured middle cerebral artery aneurysms treated with clipping surgery |
What is being measured
The primary outcome is the main question the study is designed to answer.
mRS at 3 months
the favorable outcome was defined as mRS 0-2
Measured: at 3 months
Complication
including aneurysm rupture, aneurysm recurrence, stroke and other cerebrovascular disease
Measured: during hospitalization up to 14 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jun 2021
- Study start5 Jun 2021 (estimated)
- Primary completion31 Dec 2024 (estimated)
- Study completion31 Dec 2024 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Middle Cerebral Artery AneurysmStudies of the same condition, open and under way.
- More trials run by Second Affiliated Hospital, Zhejiang University, School of MedicineThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 360 participants (estimated)
- Target duration
- 3 Months
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Collaborators
- First Affiliated Hospital of Wenzhou Medical University, Jinhua Central Hospital, Ningbo No. 1 Hospital, The Central Hospital of Lishui City, Taizhou Hospital, People's Hospital of Quzhou
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04927520
- Sponsor's protocol ID
- 2019-174
- Status last verified
- Jun 2021
- First submitted
- 5 Jun 2021
- Last updated
- 16 Jun 2021
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Jun 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Safety and Efficacy of Treatment for Middle Cerebral Artery Aneurysms: a Prospective and Multicenter Trial
- ClinicalTrials.gov ID
- NCT04927520
- Acronym / sponsor ID
- 2019-174
- Conditions
- Middle Cerebral Artery Aneurysm
- Keywords
- Middle cerebral artery aneurysms, Clipping surgery, Coil embolization, Endovascular therapy, Unruptured aneurysm
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 360 participants (estimated)
- Lead sponsor
- Second Affiliated Hospital, Zhejiang University, School of MedicineUniversity, hospital or other
- Collaborators
- First Affiliated Hospital of Wenzhou Medical University, Jinhua Central Hospital, Ningbo No. 1 Hospital, The Central Hospital of Lishui City, Taizhou Hospital, People's Hospital of Quzhou
- Study start
- 5 Jun 2021 (estimated)
- Primary completion
- 31 Dec 2024 (estimated)
- Study completion
- 31 Dec 2024 (estimated)
- First posted
- 16 Jun 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Intracranial aneurysm is one of the most common cerebrovascular diseases, with a prevalence of about 3.2%. With the aging of the population and the further popularization of MRA and other examination methods, the prevalence of intracranial aneurysm will further increase. Rupture of intracranial aneurysm is an important cause of death and severe disability in patients. The annual rate of rupture of intracranial aneurysm is about 1%, and the size of aneurysm, the location of aneurysm in the posterior circulation, and the history of subarachnoid hemorrhage on the aneurysm wall are the risk factors for aneurysm rupture. Phases are currently recognized tools for assessing the risk of aneurysm rupture, which can provide important guidance for neurosurgeons and patients to decide whether to actively intervene. In the last century, for patients with intracranial aneurysm with high risk of rupture, craniotomy and clipping for intracranial aneurysm was the gold standard for treatment.
However, with the rapid development of embolization technology and materials in the past 20 years, the application of endovascular embolization for intracranial aneurysms has been more and more widely, especially after several large prospective studies such as ISAT and ISUIA, endovascular embolization has more advantages over craniotomy clipping.Whereas, it is still very popular to adopt craniotomy clipping for middle cerebral artery aneurysms, the main reasons for which are relative superficial location, wider aneurysm neck, smaller parent artery and more branching vessels, etc., which make early endovascular embolization treatment not advantageous. With the maturity of stent-assisted embolization technology in recent years, the use of a new generation of stents, and the improvement of perioperative anti-platelet strategies, endovascular embolization has achieved good results in the treatment of middle artery aneurysms. However, these studies were retrospective, single-center studies, subject to a variety of confounding factors, and the reliability of the results is limited.
Therefore, it will be of great clinical significance to carry out a prospective, multi-center clinical study on the treatment strategy of middle cerebral artery aneurysms.
Patients with unruptured middle cerebral artery aneurysms who had been diagnosed with at least one imaging （CTA/MRA/DSA）were enrolled. The treatment including endovascular embolization and craniotomy clipping was determined according to routine management in the center. After receiving informed consent from the patients, the safety and effectiveness data were obtained to verify whether endovascular embolization was safe and effective. Through further follow-up and data analysis, protective factors and risk factors for the treatment of middle cerebral artery aneurysms were investigated. Through well-designed clinical studies, safer and more effective treatment methods can be found, and potential factors leading to perioperative complications can be found, ultimately improving the prognosis of patients with middle cerebral artery aneurysms.
Detailed description
- Data collection and management A unified and open public health platform will be established, and data will be centrally recorded in each central unit for verification by inspectors. An open network data platform for intracranial aneurysm research was established by the management personnel of different qualification levels. In order to ensure the advancement and sustainable development of the data platform construction, a public research platform for intracranial aneurysms shared in the province was built by using the keywords and retrieval items commonly used in China. After researcher training and standardized study of the scheme, the formal trial was started. A team of experts will be selected to form an inspection team, which will initiate visits to each organization and conduct the first inspection visit as soon as possible after screening the first subject. Regular monitoring visits are required until the end of the experiment. All the data were collected according to the electronic medical record (CRF) form, and then the aneurysm data (EDC) was managed according to the CRF form, and the accuracy and rigor of the data were checked in time. This study establishes a management committee, including clinical experts, evidence-based medicine experts, and CRO clinical study supervisors, who are responsible for project design, task formulation, supervision of project implementation, data analysis and formulation of standards and guidelines. The central laboratory and imaging interpretation center were established to carry out unified standard central storage for clinical specimens. The unified image and laboratory technology platform can be used for the image examination and post-processing technology in the project. Uniform standard interpretation of imaging data was carried out. A unified, standardized and efficient transmission mechanism for clinical specimens, data and data in each center was established. Establish a data management committee, set up a network data platform and be responsible for the construction and maintenance of the database, conduct real-time supervision on the quality of the input data, ensure the safety, integrity and accuracy of the data, establish and organize the implementation of the platform or offline dual-channel error correction and reminder mechanism. Set and manage the rights of all project participants on the data platform, monitor and record the data entry, modification and retrieval, set and manage the data publication of the open platform. Contact and consult statistical experts to conduct periodic analysis of data results and generate research reports. Relying on professional CRO company, in the implementation process for the implementation of the progress and quality of the implementation of random inspection supervision. At the same time, set up a data regular self-check mechanism. Establish a mechanism for regular training and evaluation of research participants. During the research progress, regular project coordination meetings were held to timely coordinate and solve problems in the process of the project.
- Sample size Sample size was calculated according to a calculation formula (α=0.05, bilateral test, 80% assurance). According to the literature and the data of the center, the rate of MRS<2 at 3 months was 95% for patients with endovascular interventional, and was 85% for those with craniotomy and clipping. The number of samples needed for each group was calculated by the software PASS15 to be at least 141. Considering that the maximum shedding rate of 20% might occur during the clinical follow-up, 180 cases were needed for each group, and 360 subjects were finally decided to be included in the study.
- Statistical Methods Statistical analysis of planned primary and secondary study endpoints will be conducted in accordance with the intentionality treatment principle. Subgroup analysis According to the needs of the experiment, the subjects can be divided into different centers, male and female, and different age groups for corresponding subgroup analysis. Methods for processing lost data Statistical analysis did not follow the study protocol population definition and other statistical methods were used to deal with lost data (e.g. multiple interpolation).
- Ethical approval of clinical research projects The study plan was reviewed and approved by the Ethics Committee of the Second Affiliated Hospital of Zhejiang University School of Medicine. The study protocol was designed and implemented in accordance with the International Conference on Harmonization for Good Clinical Practice (ICH-GCP) guidelines. In line with the national ethical behavior requirements, applicable to local laws and regulations, in strict compliance with the World Medical Association (WMA) Declaration of Helsinki ethical provisions.
- Informed Consent Process Improve the relevant examinations, check the inclusion and exclusion criteria of patients, and send the detailed information of the study to patients or their legal clients. If the patients or legal clients agree to participate in the study, they need to sign two copies of informed consent. The original consent form should be kept in the patient's study folder and another copy given to the patient. Patients or legal clients have the right to terminate their participation in the study at any time, and their decision will be recorded in the patient's study record.
- confidentiality The investigators will take every step to respect the privacy of the participants in the study. Only data that does not contain identifying information will be entered into the central research database to ensure the privacy of participants. In the process of monitoring data quality and study protocol compliance, the data monitor will refer to the medical records of the subject's clinical center and record them on the patient information sheet. In the reporting data and results, all personal information and research center information will be hidden to protect the privacy of participants.
- Adverse events management Adverse events occurred in the process of adverse events refers to the study of the subjects has a harmful effect on the health of all events. Serious Adverse Event Category: Serious Adverse Event refers to any event that occurred during the course of the study that had a serious adverse effect on the health of the subjects. Include: cause the subject to be hospitalized, prolong the length of the subject's hospital stay, cause the subject to be disabled, cause the subject's neurological or physical dysfunction, cause the subject's offspring to be born with a deformity, endanger the subject's life, the subject's death or other events that have a serious adverse effect on the subject's health. Adverse events reported to process all kinds of adverse events: take timely measures to deal with, and recorded in a report on the case. Serious adverse event (SAE) : take timely measures to deal with, and recorded in a report on the case, the researchers decided to withdrawal or by drugs, immediately report ethics committee, the drug clinical trial institution and the sponsor, 24 hours, report to the national and provincial food and drug administration. SAE is required to report adverse events and proximate errors via the Intra-hospital Network Notification System.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 3 Months
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Endovascular therapy group | – | –Unruptured middle cerebral artery aneurysms treated with coil embolization |
| Clipping surgery group | – | –Unruptured middle cerebral artery aneurysms treated with clipping surgery |
Who may qualify
- Ages
- 14 years and older
- Sex
- All
- Age groups
- Child, Adult, Older adult
- Study population
- Patients diagnosed unruptured middle artery aneurysm and treated with coil embolization or endovascular therapy
Key inclusion criteria (5 listed)
- At least 1 middle cerebral artery aneurysm confirmed by imaging (CTA/MRA/DSA);
- Accept endovascular intervention or middle cerebral artery aneurysm clip craniotomy, regardless of whether there is a clinical symptoms;
- Multiple aneurysms, whether usual treatment, but it requires the treatment time interval to > 6 months;
- The subjects currently has independent life ability, namely the mRS score 3 points or less;
- The patient or family agreed to sign a consent form.
Key exclusion criteria (8 listed)
- Patients with other intracranial vascular malformations, such as AVM and AVF;
- Fusiform, traumatic, bacterial or dissecting aneurysm;
- Ruptured middle cerebral artery aneurysm associated with intracranial hematoma;
- Intracranial or other parts of the patients with malignant tumors;
- General condition is bad, is expected to survival time less than 1 year or poor body condition, can't tolerate anesthesia or aneurysm surgery patients;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
mRS at 3 months
Time frame: at 3 months
the favorable outcome was defined as mRS 0-2
Complication
Time frame: during hospitalization up to 14 days
including aneurysm rupture, aneurysm recurrence, stroke and other cerebrovascular disease
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jun 2021.
Related trials for Middle Cerebral Artery Aneurysm
Recruiting
Middle Cerebral Artery Aneurysm Trial
Middle Cerebral Artery Aneurysm
Not yet recruitingPhase 4
Flow-diverting Devices for the Treatment of Middle Cerebral Artery Bifurcation Aneurysms
Aneurysms, Flow Diverter
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Middle Cerebral Artery Aneurysm, run by Second Affiliated Hospital, Zhejiang University, School of Medicine at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 16 Jun 2021. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Xu Jing (+86-13958119687, jingxu@zju.edu.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
mRS at 3 months (time frame: at 3 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jun 2021.