AzTrials
AzTrials

Non-alcoholic SteatohepatitisPhase 3ESSENCENCT04822181

Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

A Phase 3 study testing Semaglutide in people with Non-alcoholic Steatohepatitis, run by Novo Nordisk A/S at 558 sites in 39 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
Search all trials

Trial summary

Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries. Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Non-alcoholic Steatohepatitis
What is being tested?
Semaglutide
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
1,205 participants
Where
558 sitesin 39 countries
Study dates
1 Apr 2021to 25 Apr 2029
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Age above or equal to 18 years at the time of signing informed consent.
  • Histological evidence of NASH based on a central pathologist evaluation of the baseline liver biopsy. The baseline liver biopsy can be a historical biopsy obtained within 180 days prior to the screening visit (V1).
  • Histological evidence of fibrosis stage 2 or stage 3 according to the NASH CRN (Clinical Research Network) classification based on a central pathologist evaluation of the baseline liver biopsy.
  • A histological NAS (Non-alcoholic fatty liver disease Activity Score) above or equal to 4 with a score of 1 or more in steatosis, lobular inflammation and hepatocyte ballooning based on a central pathologist evaluation of the baseline liver biopsy.

Who cannot join

  • Documented causes of chronic liver disease other than non-alcoholic fatty liver disease (NAFLD)
  • Positive HBsAg, positive anti-HIV, positive HCV RNA at screening (V2A) or any known presence of HCV RNA or HBsAg within 2 years of screening (V2A).
  • Presence or history of ascites, variceal bleeding, hepatic encephalopathy, spontaneous bacterial peritonitis or liver transplantation at randomisation.
  • Known or suspected excessive consumption of alcohol (greater than 20 g/day for women or greater than 30 g/day for men) or alcohol dependence (assessed by the Alcohol Use Disorders Identification Test (AUDIT questionnaire)).
  • Treatment with vitamin E (at doses greater than or equal to 800 IU/day) or pioglitazone or medications approved for treatment of NASH which has not been at a stable dose in the period from 90 days prior to the screening visit (V2A). In addition, for subjects with historical liver biopsies taken more than 90 days prior to screening, treatment should be at a stable dose from time of biopsy until screening.
  • Treatment with GLP-1 RAs in the period from 90 days prior to the screening visit (V2A). In addition, for subjects with historical liver biopsies taken more than 90 days prior to screening, any treatment with GLP-1 RAs from time of biopsy until screening (V2A).
  • Treatment with glucose-lowering agent(s) (other than GLP-1 RAs), lipid-lowering medication or weight loss medication not stable in the opinion of the investigator in the period from 90 days prior to the screening visit (V2A). In addition, for subjects with historical liver biopsies taken more than 90 days prior to screening, treatment should be at a stable dose in the opinion of the investigator from time of biopsy until screening.

Trial locations and contacts

558 sites in 39 countries.

558 sites in 39 countries

United States130 sites

  • Amarillo Center for Clinical Research, Ltd.

    Amarillo, Texas, 79106

  • University of Michigan Medicine

    Ann Arbor, Michigan, 48109

  • Texas Clin Res Inst, LLC

    Arlington, Texas, 76012

  • Emory University Hospital

    Atlanta, Georgia, 30322-1059

  • Mercy Medical Center, GI Research

    Baltimore, Maryland, 21202

  • Walter Reed Nat Mil Md Ctr

    Bethesda, Maryland, 20889

  • Boston Medical Center_Cary

    Boston, Massachusetts, 02118

  • Encore Medical Research of Boynton Beach LLC

    Boynton Beach, Florida, 33436

  • The Institute for Liver Health

    Chandler, Arizona, 85224

  • Medical University Of South Carolina

    Charleston, South Carolina, 29425

  • AtriumHealth Liver Care, Pineville

    Charlotte, North Carolina, 28210

  • University Of Virginia Hospital

    Charlottesville, Virginia, 22908

  • WR-ClinSearch, LLC

    Chattanooga, Tennessee, 37421

  • Clinical Research Professionals

    Chesterfield, Missouri, 63005

  • Rush University Med. Cntr

    Chicago, Illinois, 60612

  • University Of Chicago

    Chicago, Illinois, 60637

  • Iowa Digestive Disease Center

    Clive, Iowa, 50325

  • Peak Gastro Assoc-Col Springs

    Colorado Springs, Colorado, 80907

  • Columbus Regional Research Institute

    Columbus, Georgia, 31904

  • Ohio State Univ Wexner Med Ctr

    Columbus, Ohio, 43210

  • Northeast GI Research Division

    Concord, North Carolina, 28027

  • Clinical Res Collaborative

    Cumberland, Rhode Island, 02864

  • Liver Ins@ Mthdist DTX Med Cen

    Dallas, Texas, 75203

  • Velocity Clinical Res-Dallas

    Dallas, Texas, 75230

  • UT Southwestern Med Cntr

    Dallas, Texas, 75390-9302

  • Geisinger Clinic

    Danville, Pennsylvania, 17822

  • Henry Ford Health System

    Detroit, Michigan, 48202

  • Integrity Clinical Research, LLC

    Doral, Florida, 33122

  • Duke Univ. Med CNTR_Durham_2

    Durham, North Carolina, 27710

  • South Texas Research Institute

    Edinburg, Texas, 78539

  • Gastroenterology & Liver Institute

    Escondido, California, 92025

  • Inova Fairfax Medical Campus

    Falls Church, Virginia, 22042

  • AIG Digestive Disease Research

    Florham Park, New Jersey, 07932

  • Covenant Metabolic Specialists, Ft. Myers

    Fort Myers, Florida, 33912

  • Brooke Army Medical Ctr.

    Fort Sam Houston, Texas, 78234

  • GI Alliance Research

    Fort Worth, Texas, 76104

  • University of Florida-CTRB

    Gainesville, Florida, 32610

  • Woodholme Gastroenterology Associates

    Glen Burnie, Maryland, 21061

  • Shang Wu M.D. Inc.

    Hacienda Heights, California, 91745

  • Digestive Health Res-TSMC

    Hermitage, Tennessee, 37076

  • Pennsylvania State University

    Hershey, Pennsylvania, 17033

  • Miguel Rebollar PA

    Hialeah, Florida, 33012

  • Direct Helpers Research Center

    Hialeah, Florida, 33016

  • Tandem Clinical Research - Houma

    Houma, Louisiana, 70363

  • Bylr Coll Md-Ben Taub Gen Hos

    Houston, Texas, 77030-1608

  • Baylor College Of Medicine

    Houston, Texas, 77030

  • Houston Methodist Hospital

    Houston, Texas, 77030

  • Bipharma Informatic Inc.

    Houston, Texas, 77043

  • Houston Research Institute

    Houston, Texas, 77079

  • Biopharma Informatic

    Houston, Texas, 77084

  • Amir Ali Hassan, MD, PA

    Houston, Texas, 77089

  • North AL Health Res, LLC

    Huntsville, Alabama, 35801

  • Indiana University Hospital

    Indianapolis, Indiana, 46202

  • Southern Therapy and Advanced Research LLC

    Jackson, Mississippi, 39216

  • East Tennessee Research Institute

    Johnson City, Tennessee, 37604

  • ARcare Center for Clinical Research

    Jonesboro, Arkansas, 72401

  • University Of Kansas Hospital

    Kansas City, Kansas, 66160

  • Kansas City Research Institute

    Kansas City, Missouri, 64131

  • Scripps Whittier Diabetes Inst

    La Jolla, California, 92037

  • UCSD NAFLD Research Center

    La Jolla, California, 92037

  • Florida Research Institute, LLC

    Lakewood Rch, Florida, 34211-4930

  • OM Research LLC

    Lancaster, California, 93534

  • Jubilee Clinical Research, Inc.

    Las Vegas, Nevada, 89106

  • Sierra Clinical Research-Las Vegas

    Las Vegas, Nevada, 89106

  • Ocean St Clin Res Partnrs, LLC

    Lincoln, Rhode Island, 02865

  • ARcare Center for Clinical Research

    Little Rock, Arkansas, 72205

  • Arkansas Diagnostic Center, PA

    Little Rock, Arkansas, 72205

  • Digestive Hlth Res of SoCa

    Long Beach, California, 90808

  • Gastroenterology Assoc_ CGA

    Macon, Georgia, 31201

  • Sandhill Research, LLC

    Maitland, Florida, 32751

  • Tandem Clinical Research - Maitland

    Maitland, Florida, 32751

  • Gastroint Spec of Georgia

    Marietta, Georgia, 30060

  • Tandem Clinical Research

    Marrero, Louisiana, 70072

  • Centex Studies - McAllen

    McAllen, Texas, 78504

  • Tandem Clinical Research - Metairie

    Metairie, Louisiana, 70006

  • Optimus U, Corp

    Miami, Florida, 33135

  • Univ of Miami/Schiff Ctr

    Miami, Florida, 33136

  • Genoma Research Group, Inc

    Miami, Florida, 33173

  • IMIC Inc

    Miami, Florida, 33176

  • San Marcus Res Clin Miami Lakes

    Miami Lakes, Florida, 33014

  • Quality Medical Research

    Nashville, Tennessee, 37211

  • Yale Ctr for Clin Invest

    New Haven, Connecticut, 06519

  • NYU Grossman School of Med

    New York, New York, 10016

  • Weill Cornell Med Coll-NYPH

    New York, New York, 10021

  • Icahn Sch of Med-Mt Sinai Hosp

    New York, New York, 10029

  • Digestive and Liver Disease Specialists

    Norfolk, Virginia, 23502

  • Ocala GI Research

    Ocala, Florida, 34471

  • Sensible Healthcare LLC

    Ocoee, Florida, 34761

  • South Ogden Family Medicine/ CCT Research

    Ogden, Utah, 84405

  • Univ of Nebraska Medical CTR

    Omaha, Nebraska, 68198-3020

  • OM Research LLC

    Oxnard, California, 93030

  • Cedars-Sinai Medical Center

    Pasadena, California, 90048

  • Pasedena Liver Center

    Pasadena, California, 91105

  • LinQ Research, LLC

    Pearland, Texas, 77584

  • Inst-Liver Hlth dba AZ Liver H

    Peoria, Arizona, 85381

  • Univ of Pennsylvania Hospital

    Philadelphia, Pennsylvania, 19104

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107-5244

  • UPMC Center for Liver Diseases

    Pittsburgh, Pennsylvania, 15213

  • UPMC_Center for Liver Care

    Pittsburgh, Pennsylvania, 15213

  • Care Access Research, Pottsville

    Pottsville, Pennsylvania, 17901

  • Inland Empire Clin Trials LLC

    Rialto, California, 92377

  • Bon Secours Richmond Community Hospital LLC

    Richmond, Virginia, 23226

  • McGuire VA Medical Center

    Richmond, Virginia, 23249

  • VCU Health System

    Richmond, Virginia, 23298

  • Velocity Clinical Research, Riverton

    Riverton, Utah, 84065

  • Gastroent Consult of SW VA

    Roanoke, Virginia, 24014

  • Mayo Clinic

    Rochester, Minnesota, 55905-0001

  • UC Davis Hlth -Midtwn Ambu Cen

    Sacramento, California, 95817

  • University of Utah

    Salt Lake City, Utah, 84132

  • Amer. Rrsch Corp-TX Liver Inst

    San Antonio, Texas, 78215

  • Clinical Trials of Texas, LLC

    San Antonio, Texas, 78229

  • University of California, San Francisco

    San Francisco, California, 94143

  • San Jose Gastroenterology

    San Jose, California, 95116

  • Covenant Metabolic Specialists LLC

    Sarasota, Florida, 34240

  • Headlands Research - Sarasota

    Sarasota, Florida, 34243

  • Louisiana Research Center, LLC

    Shreveport, Louisiana, 71105

  • Endeavor Health

    Skokie, Illinois, 60077

  • Digestive Research Alliance of Michiana

    South Bend, Indiana, 46635

  • Premier Health Research, LLC

    Sparta, New Jersey, 07871

  • Objective GI

    Springboro, Ohio, 45066

  • Theia Clinical Research Centers LLC

    St. Petersburg, Florida, 33710

  • Mt Olympus Medical Research, LLC

    Sugar Land, Texas, 77479

  • Kansas Medical Clinic, PA

    Topeka, Kansas, 66606

  • Inst. Liver H II dba AZ Liver H

    Tucson, Arizona, 85712

  • Del Sol Research Management, LLC

    Tucson, Arizona, 85715

  • Options Health Research, LLC

    Tulsa, Oklahoma, 74104

  • ClinCloud, LLC

    Viera E., Florida, 32940

  • CRIOH

    Westlake, Ohio, 44145

  • Digestive Hlth Res of N Texas

    Wichita Falls, Texas, 76301

  • Florida Medical Clinic Orlando Health

    Zephyrhills, Florida, 33542

Other trials in United States

Japan59 sites

  • Juntendo University Hospital, Gastroenterology

    Bunkyo-ku, Tokyo, 113-8431

  • Juntendo University Hospital_Gastroenterology

    Bunkyo-ku, Tokyo, 113-8431

  • The University of Tokyo Hospital, Gastroenterology

    Bunkyo-ku, Tokyo, 113-8655

  • Fukui-ken Saiseikai Hospital, Internal Medicine

    Fukui-shi, Fukui, 918-8503

  • Fukui-ken Saiseikai Hospital_Internal Medicine

    Fukui-shi, Fukui, 918-8503

  • Hoshi General Hospital_Gastroenterology

    Fukushima, 963-8801

  • Gifu Municipal Hospital_Hepatology

    Gifu, 500-8513

  • Ogaki Municipal Hospital_Gastroenterology and Hepatology

    Gifu, 503-8502

  • Hamamatsu University Hospital_Liver Internal Medicine

    Hamamatsu-shi, Shizuoka, 431-3192

  • JA Hiroshima General Hospital_Gastroenterology and Hepatology

    Hatsukaichi-shi, Hiroshima, 783-8503

  • Hiroshima Red Cross & Atomic-b_Hepatology

    Hiroshima-shi, Hiroshima, 730-8619

  • Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hosp.

    Hiroshima-shi, Hiroshima, 730-8619

  • Hiroshima University Hospital_Department of Gastro.&Metabo.

    Hiroshima-shi, Hiroshima, 734-8551

  • Hiroshima University Hospital

    Hiroshima-shi, Hiroshima, 734-8551

  • Juntendo University Shizuoka Hospital_Gastroenterology & Hepatology

    Izunokuni-shi, Shizuoka, 410-2295

  • Juntendo University Shizuoka Hospital

    Izunokuni-shi, Shizuoka, 410-2295

  • Kagoshima University Hospital, Gastroenterology

    Kagoshima-shi, Kagoshima, 890-8520

  • Kagoshima University Hospital_Gastroenterology

    Kagoshima-shi, Kagoshima, 890-8520

  • University Hospital Kyoto Prefectual University of Medicine

    Kamigyo-ku, Kyoto, 602-8566

  • Kanazawa University Hospital_Gastroenterology

    Kanazawa-shi, Ishikawa, 920-8641

  • Kanazawa University Hospital

    Kanazawa-shi, Ishikawa, 920-8641

  • Nara Medical University Hospital_Department of Gastro.& Metabo.

    Kashihara-shi, Nara, 634-8522

  • Nara Medical University Hospital_Kashihara-shi, Nara

    Kashihara-shi, Nara, 634-8522

  • St. Marianna University School of Medicine Hospital_Division of Gastro.&Hepato.

    Kawasaki-shi, Kanagawa, 216-8511

  • St. Marianna University School of Medicine Hospital

    Kawasaki-shi, Kanagawa, 216-8511

  • Kumamoto Shinto General Hospital_Liver・Gastroenterology

    Kumamoto-shi, Kumamoto, 862-8655

  • Toranomon Hospital, Hepatology

    Minato-ku, Tokyo, 105-8470

  • Japanese Red Cross Musashino Hospital_Gastroenterology

    Musashino-shi, Tokyo, 180-8610

  • Japanese Red Cross Musashino Hospital

    Musashino-shi, Tokyo, 180-8610

  • Aichi Medical University Hospital_Hepatology and pancreology

    Nagakute-shi, Aichi, 480-1195

  • Aichi Medical University Hospital

    Nagakute-shi, Aichi, 480-1195

  • Heartlife Hospital_Liver internal medicine

    Nakagamigun, Okinawa, 901-2492

  • Nara City Hospital, Gastroenterology and Hepatology

    Nara-shi, Nara, 630-8305

  • Hyogo Medical University Hospital_Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine

    Nishinomiya-shi, Hyogo, 663-8501

  • Oita Cardiovascular Hospital_Gastroenterology

    Oita-shi, Oita, 870-0837

  • Kawasaki Medical School General Medical Center_Internal Medicine

    Okayama-shi, Okayama, 700-8505

  • Kawasaki Medical School General Medical Center

    Okayama-shi, Okayama, 700-8505

  • Japan Organization of Occupational Health and Safety Osaka Rosai Hospital_Gastroenterology

    Osaka, 591-8025

  • Osaka Metropolitan University Hospital, Department of Hepatology

    Osaka-shi, Osaka, 545-8586

  • Osaka Metropolitan University Hospital_Department of Hepatology

    Osaka-shi, Osaka, 545-8586

  • Otsu City Hospital, Gastroenterological Medicine

    Otsu-shi, Shiga, 520-0804

  • Saga University Hospital_Liver Center

    Saga-shi, Saga, 849-8501

  • Japan Community Health care Organization Hokkaido Hospital

    Sapporo-shi, Hokkaido, 062-8618

  • JCHO Hokkaido Hospital_Digestive Disease Center

    Sapporo-shi, Hokkaido, 062-8618

  • Sendai Kousei Hospital_Liver Internal Medicine

    Sendai-shi, Miyagi, 981-0914

  • Sendai Kousei Hospital

    Sendai-shi, Miyagi, 981-0914

  • Tokyo Women's Medical University Hospital

    Shinjuku-ku, Tokyo, 162-8666

  • Saiseikai Suita Hospital, Gastroenterology

    Suita-shi, Osaka, 564-0013

  • Osaka University Hospital_Department of Gastro. & Hepato

    Suita-shi, Osaka, 565-0871

  • Kagawa Prefectural Central Hospital_Liver internal medicine

    Takamatsu-shi, Kagawa, 760-8557

  • Kagawa Prefectural Central Hospital

    Takamatsu-shi, Kagawa, 760-8557

  • National Hospital Organization Takasaki General Medical Ctr._Gastroenterology

    Takasaki-shi, Gunma, 370-0829

  • Nihon University Itabashi Hospital_Division of Gastro.&Hepa.

    Tokyo, 173-8610

  • Nihon University Itabashi Hospital

    Tokyo, 173-8610

  • Ehime University Hospital_Department of Gastro.& Metabo.

    Toon-shi, Ehime, 791-0295

  • Ehime University Hospital

    Toon-shi, Ehime, 791-0295

  • Saiseikai Wakayama Hospital_Gastroenterology

    Wakayama-shi, Wakayama, 640-8158

  • Saiseikai Wakayama Hospital

    Wakayama-shi, Wakayama, 640-8158

  • Yokohama City University Hospital_Gastrointestinal Medicine

    Yokohama-shi, Kanagawa, 236-0004

Other trials in Japan

China41 sites

  • Beijing Ditan Hospital Capital Medical University-Hepatology

    Beijing, Beijing Municipality, 100015

  • Peking University People's Hospital-(White Pagoda Temple Area) - Hepatopathy

    Beijing, Beijing Municipality, 100034

  • Beijing Friendship Hospital, Capital Medical University-Endocrinology

    Beijing, Beijing Municipality, 100050

  • Beijing You'an Hospital, Capital Medical University-Hepatology center

    Beijing, Beijing Municipality, 100069

  • Beijing Tsinghua Changgung Hospital-Hepatology

    Beijing, Beijing Municipality, 102218

  • The First Bethune Hospital of Jilin University-Hepatic Biliary Pancreatic Medicine

    Changchun, Jilin, 130021

  • Hunan Provincial People's Hospital-Hepatology

    Changsha, Hunan, 410005

  • Hunan Provincial People's Hospital

    Changsha, Hunan, 410005

  • Changzhou No.2 People's Hospital

    Changzhou, Jiangsu, 213003

  • West China Hospital Sichuan University-Infectious Diseases

    Chengdu, Sichuan, 610044

  • Chongqing University Three Gorges Hospital-Hepatology

    Chongqing, Chongqing Municipality, 404140

  • The First People's Hospital of Foshan-Infectious Disease

    Foshan, Guangdong, 528000

  • Guangzhou Eighth People's Hospital, Guangzhou Medical University-Hepatology

    Guangzhou, Guangdong, 510060

  • The First Affiliated Hospital, Sun Yat-sen University

    Guangzhou, Guangdong, 510080

  • Guangzhou First People's Hospital-Gastroenterology

    Guangzhou, Guangdong, 510180

  • Nanfang Hospital, Southern Medical University-Infectious Diseases

    Guangzhou, Guangdong, 510515

  • The Third Affiliated Hospital, Sun Yat-sen University-Infectious

    Guangzhou, Guangdong, 510650

  • Zhejiang Hospital-Infectious Diseases

    Hangzhou, Zhejiang, 310030

  • Zhejiang Hospital-Infectious Diseases

    Hangzhou, 310030

  • Jinan Central Hospital

    Jinan, Shandong, 250013

  • Liaocheng People's Hospital-Infectious Diseases

    Liaocheng, Shandong, 252000

  • Liaocheng People's Hospital

    Liaocheng, Shandong, 252000

  • The First Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006

  • The Second Affiliated Hospital of Nanjing Medical University-Hepatology

    Nanjing, Jiangsu, 210003

  • Qingdao Municipal Hospital (Group)-Infectious Diseases

    Qingdao, Shandong, 266011

  • Shanghai Jiao Tong University School of Medicine Renji Hospital-Gastroenterology

    Shanghai, Shanghai Municipality, 200001

  • Ruijin Hospital Affiliate to The Shanghai Jiaotong University-Infectious Diseases

    Shanghai, Shanghai Municipality, 200025

  • Ruijin Hospital Affiliate to The Shanghai Jiaotong Universit

    Shanghai, Shanghai Municipality, 200025

  • Shanghai Ninth People's Hospital-Infection Disease

    Shanghai, Shanghai Municipality, 201999

  • Shanghai Ninth People's Hospital

    Shanghai, Shanghai Municipality, 201999

  • Peking University Shenzhen Hospital

    Shenzhen, Guangdong, 518036

  • The Third People's Hospital of Shenzhen-Hepatology

    Shenzhen, Guangdong, 518112

  • The Third People's Hospital of Shenzhen

    Shenzhen, 518112

  • The Third Hospital of Hebei Medical University-Hepatology

    Shijiazhuang, Hebei, 050051

  • Tianjin Third Central Hospital-Gastroenterology

    Tianjin, Tianjin Municipality, 300170

  • Tianjin Second People's Hospital-Liver Disease Department III

    Tianjin, Tianjin Municipality, 300211

  • Tianjin Second People's Hospital-Liver Disease Department III

    Tianjin, 300211

  • The First Affiliated Hospital of WMU

    Wenzhou, Zhejiang, 325000

  • The Affiliated Hospital of Xuzhou Medical University (East) - Infectious Diseases

    Xuzhou, Jiangsu, 221011

  • General Hosp of Ningxia Medical University,Infectious Depart

    Yinchuan, Ningxia, 750004

  • The Third People's Hospital of Zhenjiang-Hepatology

    Zhenjiang, Jiangsu, 212021

Other trials in China

United Kingdom26 sites

  • Royal Victoria Hospital

    Belfast, BT12 6BA

  • Queen Elizabeth Hospital, Birmingham

    Birmingham, B15 2TH

  • University Hospital Coventry - WISDEM Centre

    Coventry, CV2 2DX

  • Royal Derby Hospital

    Derby, DE22 3DT

  • Royal Derby Hospital

    Derby, DE22 3NE

  • Ninewells Hospital

    Dundee, DD1 9SY

  • Royal Devon and Exeter Hospital

    Exeter, EX2 5DW

  • Hull Royal Infirmary_Hull

    Hull, HU3 2GZ

  • Hull Royal Infirmary

    Hull, HU3 2GZ

  • Ipswich Hospital - Diabetes

    Ipswich, IP4 5PD

  • The Diabetes Centre

    Ipswich, IP4 5RH

  • St James's University Hospital

    Leeds, LS9 7TF

  • St. James University Hospital

    Leeds, LS9 7TF

  • The Royal London Hospital - Grahame Hayton Unit

    London, E1 1FR

  • Royal Free Hospital - Immunity & Transplantation

    London, NW3 2QG

  • Institute of Liver Studies

    London, SE5 9RS

  • Chelsea & Westminster Hospital

    London, SW10 9NH

  • Imperial College London

    London, W2 1NY

  • Freeman Hospital, Newcastle

    Newcastle upon Tyne, NE7 7DN

  • Nottingham University Hospitals NHS Trust

    Nottingham, NG7 2UH

  • Nottingham University Hospital

    Nottingham, NG7 2UH

  • John Radcliffe Hospital

    Oxford, OX3 9DU

  • Derriford Hospital - Plymouth

    Plymouth, PL6 8DH

  • Northern General Hospital

    Sheffield, S5 7AU

  • Southampton General Hospital

    Southampton, SO16 6YD

  • Joint Clinical Research Facility - Swansea

    Swansea, SA2 8PP

Other trials in United Kingdom

India19 sites

  • Post Graduate Institute of Medical Education & Research_Chandigarh

    Chandigarh, Punjab, 160012

  • All India Institute of medical Sciences

    Delhi, New Delhi, 110029

  • Institute of liver and Biliary Sciences

    Ghitorni, New Delhi, 110070

  • Medanta - The Medicity Multi-Speciality Hospital, Gurugram

    Gurgaon, Haryana, 122001

  • Osmania General Hospital_Hyderabad

    Hyderabad, Telangana, 500012

  • Dr P V Rao - Diabetes Research Centre

    Hyderabad, Telangana, 50082

  • S.R.Kalla Memorial Gastro & General Hospital

    Jaipur, Rajasthan, 302001

  • SMS Super speciality Hospital, Department of Gastroenterology

    Jaipur, Rajasthan, 302004

  • MV Hospital and Research Centre

    Lucknow, Uttar Pradesh, 226003

  • Dayanand Medical College & Hospital

    Ludhiana, Punjab, 141001

  • Kasturba Medical College Hospitals (KMC Hospitals), Mangalore

    Mangalore, Karnataka, 575001

  • Fortis Heart Institute and Multispeciality Hospital

    Mohali, Punjab, 160062

  • Gleneagles Hospital, Super-speciality and Transplant Centre, Parel

    Mumbai, Maharashtra, 400012

  • Seth GS medical college and KEM Hospital

    Mumbai, Maharashtra, 400012

  • Midas Multispeciality Hospital

    Nagpur, Maharashtra, 441108

  • Fortis Escort Heart Institute

    New Delhi, 110025

  • Yashoda Hospital

    Secunderabad, Andhra Pradesh, 500003

  • Surat Institute of Digestive Science

    Surat, Gujarat, 395002

  • BAPS Pramukh Swami Hospital

    Surat, Gujarat, 395009

Other trials in India

Turkey (Türkiye)18 sites

  • T.C. Saglık Bakanlıgı Adana Sehir Egitim ve Arastirma Hastan

    Adana, 01000

  • Hacettepe Universitesi Tıp Fakültesi- Gastroenteroloji

    Ankara, 06230

  • Ankara Universitesi Tıp Fakultesi Gastroenteroloji Bilim Da

    Ankara, 06590

  • Ankara Üniversitesi Tıp Fakültesi Cebeci Araştırma Ve Uygulama Hastanesi-Gastroenteroloji

    Ankara, 06590

  • Ankara Bilkent Şehir Hastanesi-Gastroenteroloji

    Ankara, 06800

  • Ankara Sehir Hastanesi,Gastroenteroloji Klinigi

    Ankara, 06800

  • Bursa Uludağ Üniversitesi Hastanesi-Gastroenteroloji

    Bursa, 16059

  • Uludag Universitesi Tıp Fakultesi-Gastroenteroloji

    Bursa, 16059

  • Koc Universitesi Hastanesi-Gastroenteroloji

    Istanbul, 34010

  • Bezmialem Vakıf Üniversitesi Hastanesi-Gastroenteroloji

    Istanbul, 34093

  • Istanbul Universitesi Istanbul Tip Fakultesi-Gastroenterolog

    Istanbul, 34093

  • Umraniye Egitim ve Arastirma Hastanesi, Gastroenteroloji

    Istanbul, 34764

  • Marmara Üniversitesi Pendik EAH- Gastroenteroloji

    Istanbul, 34899

  • Ege Universitesi Tip Fakultesi Hastanesi, Gastroenteroloji

    Izmir, 35100

  • Kocaeli Üniversitesi Hastanesi - Gastroenteroloji

    Kocaeli, 41000

  • Mersin Universitesi Tip Fakultesi Gastroenteroloji Bilim Dal

    Mersin, 33343

  • Mersin Üniversitesi Tip Fakültesi Hastanesi -Gastroenteroloji

    Mersin, 33343

  • Adana Şehir Eğitim ve Araştırma Hastanesi-Endokrinoloji

    Yüreğir/Adana, 1370

Other trials in Turkey (Türkiye)

Russia17 sites

  • Volosevich First City Clinical Hospital

    Arkhangelsk, 163001

  • City Hospital #5

    Barnaul, 656045

  • Kazan Federal University

    Kazan', 420097

  • LLC "Clinic of Aesthetic Medicine & Laser Technologies"

    Kazan', 420111

  • Friendship University of Russia

    Moscow, 117292

  • Setchenov First Moscow State Medical University

    Moscow, 119435

  • PHI "Central Clinical Hospital RZD- Medicine"

    Moscow, 125367

  • Limited Law Company "Healthy Family" Medicine Center"

    Novosibirsk, 630099

  • Penza Regional Clinical Hospital named after N.N. Burdenko

    Penza, 440026

  • Joint Stock Company "Polyclinic Complex"

    Saint Petersburg, 190013

  • SPb SBHI City Outpatient clinic #109

    Saint Petersburg, 192283

  • Limited Liability Company "Energiya Zdoroviya"

    Saint Petersburg, 194156

  • North-Western State Medical Univer. based on Med-Prof Center

    Saint Petersburg, 195067

  • Consultative & Diagnostic Center with a Outpatient Hospital

    Saint Petersburg, 197110

  • Siberian State Medical University

    Tomsk, 634050

  • Ulianovsk Regional Clinical Hospital

    Ulyanovsk, 432063

  • Polyclinic #2 in Yoshkar-Ola

    Yoshkar-Ola, 424004

Other trials in Russia

Bulgaria15 sites

  • MHAT - Uni Hospital OOD

    Panagyurishte, 4500

  • MHAT Med Line Clinic

    Plovdiv, 4000

  • "Acibadem City Clinic UMHAT Tokuda"

    Sofia, 1407

  • Acibadem City Clinic UMHAT Tokuda EAD, Gastroenterology

    Sofia, 1407

  • DCC Aleksandrovska EOOD

    Sofia, 1431

  • UMHAT Sveti Ivan Rilski EAD, Gastroenterology

    Sofia, 1431

  • Medical Center Vertebra OOD

    Sofia, 1504

  • "UMHAT "Tsaritsa Yoanna-ISUL"" EAD, Gastroenterology clinic

    Sofia, 1527

  • UMHAT Tsaritsa Yoanna - ISUL EAD, Gastroenterology

    Sofia, 1527

  • "DCC XX - Sofia" EOOD

    Sofia, 1618

  • DCC XX - Sofia EOOD, Gastroenterology

    Sofia, 1618

  • "UMHAT "Sveta Anna" Sofia" AD

    Sofia, 1750

  • Acibadem City Clinic UMHAT EOOD, Gastroenterology

    Sofia, 1784

  • Medical Center Synexus Sofia EOOD

    Sofia, 1784

  • UMHAT Sveta Marina EAD, Clinic of Gastroenterology

    Varna, 9010

Other trials in Bulgaria

Portugal15 sites

  • Hospital Garcia de Orta

    Almada, 2805-267

  • ULS De Almada-Seixal E.P.E. - Hospital Garcia de Orta

    Almada, 2805-267

  • ULS Da Regiao De Aveiro E.P.E. - Hospital Infante D. Pedro

    Aveiro, 3814-501

  • ULS De Braga, E.P.E. - Hospital de Braga

    Braga, 4710-243

  • ULS Da Guarda E.P.E. - Hospital Sousa Martins

    Guarda, 6301-858

  • ULS Do Alto Ave, E.P.E. - Hospital Senhora da Oliveira - Guimarães

    Guimarães, 4835-044

  • APDP - Associação Protectora dos Diabéticos de Portugal

    Lisbon, 1250-189

  • Unidade De Santa Maria E.P.E. - Hospital de Santa Maria

    Lisbon, 1649-035

  • ULS De Santo António, E.P.E. - Hospital de Santo António

    Porto, 4099-001

  • ULS De São João, E.P.E. - Hospital de São João

    Porto, 4200-319

  • ULS De Matosinhos E.P.E.- Hospital Pedro Hispano

    Senhora Da Hora, Matosinhos, Matosinhos, 4464-513

  • ULS Do Alto Minho E.P.E. - Hospital de Santa Luzia

    Viana do Castelo, 4904-858

  • Hospital da Luz Arrabida, S.A.

    Vila Nova de Gaia, 4400-346

  • ULS De Gaia/Espinho E.P.E. - Hospital Eduardo Santos Silva

    Vila Nova de Gaia, 4434-502

  • ULS De Tras-Os-Montes E Alto Douro E.P.E. - Unidade Hospitalar de Vila Real

    Vila Real, 5000-508

Other trials in Portugal

Canada13 sites

  • LMC ClinRsrh Inc.Brampton

    Brampton, Ontario, L6S 0C6

  • University of Calgary Liver Unit-(HMRC)

    Calgary, Alberta, T2N 4Z6

  • Ecogene-21

    Chicoutimi, Quebec, G7H 7K9

  • Nova Scotia Hlth Halifax

    Halifax, Nova Scotia, B3H 2Y9

  • London Hlth Sci Ctr- Univ Camp

    London, Ontario, N6A 5A5

  • McGill University Health Centre

    Montreal, Quebec, H4A 3J1

  • Clinique Medicine Urbaine du Quartier Latin, Inc.

    Montreal, Quebec, QC H2L 4E9

  • Hospital Fleurimont / CIUSS

    Sherbrooke, Quebec, J1H 5N4

  • Ctr de Med Metab de Lanaudiere

    Terrebonne, Quebec, J6X 4P7

  • Centricity Research LMC (Toronto)

    Toronto, Ontario, M4G 3E8

  • Toronto Liver Centre

    Toronto, Ontario, M6H 3M1

  • GI Research Inst Foundation

    Vancouver, British Columbia, V6Z 2K5

  • TDDA Specialty Research

    Vaughan, Ontario, L4L 4Y7

Other trials in Canada

Germany13 sites

  • Gastro am Bayerischen Platz - Hofmann W.-P.n

    Berlin, 10825

  • Charité - Campus Virchow-Klinikum - Med. Klinik für Hepatologie und Gastroenterologie

    Berlin, 13353

  • Uniklinik Knappschaftskrankenhaus Bochum GmbH - Med. Klinik - Gastroenterologie & Hepatologie

    Bochum, 44892

  • Universitätsklinikum Bonn - Med. Klinik und Poliklinik I

    Bonn, 53127

  • Uniklinik FFM - Hepatologie

    Frankfurt, 60590

  • Medizinische Hochschule Hannover - Gastroentero-, Hepato-, Endokrinologie

    Hanover, 30625

  • Prof. Dr. Schiefke Ingolf, EUGASTRO GmbH

    Leipzig, 04103

  • Universitätsklinikum Leipzig - Klinik und Poliklinik für Onkologie, Gastroenterologie, Hepatologie und Pneumologie

    Leipzig, 04103

  • Uniklinik Schleswig-Holstein - Medizinischen Klinik I am Campus Lübeck

    Lübeck, 23538

  • Uniklinik Otto Von Guericke Magdeburg - Gastroenterologie, Hepatologie and Infektiologie

    Magdeburg, 39120

  • Universitätsmedizin der JGU Mainz - Hepatologie

    Mainz, 55131

  • Universitätsmedizin Mannheim - II. Medizinische Klinik

    Mannheim, 68167

  • Universitätsklinikum Würzburg - Zentrum für Innere Medizin (ZIM)

    Würzburg, 97080

Other trials in Germany

Australia12 sites

  • Royal Adelaide Hospital - Hepatology Department

    Adelaide, South Australia, 5000

  • A.W. Morrow Gastroenterology and Liver Centre

    Camperdown, New South Wales, 2050

  • Lyell McEwin Hospital

    Elizabeth Vale, South Australia, 5112

  • St Vincent's Hospital Melbourne - Gastroenterology Department

    Fitzroy, Victoria, 3065

  • Austin Hospital

    Heidelberg, Victoria, 3084

  • Nepean Hospital

    Kingswood, New South Wales, 2747

  • Liverpool Hospital

    Liverpool, New South Wales, 2170

  • Fiona Stanley Hospital - Hepatology

    Murdoch, Western Australia, 6150

  • Sir Charles Gairdner Hospital - Hepatology Department

    Nedlands, Western Australia, 6009

  • Griffith University Clinical Trial Unit

    Southport, Queensland, 4222

  • Westmead Hospital - Storr Liver Centre

    Westmead, New South Wales, 2145

  • Westmead Hospital

    Westmead, New South Wales, 2145

Other trials in Australia

Brazil11 sites

  • Fundação Pio XII

    Barretos, São Paulo, 14780-070

  • Fundação Pio XII - Hospital de Amor de Barretos

    Barretos, São Paulo, 14784-400

  • UPECLIN- Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu

    Botucatu, São Paulo, 18618-686

  • Hospital das Clínicas da Universidade Federal de Goiás

    Goiânia, Goiás, 74605-020

  • Hospital de Clínicas de Porto Alegre_Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90035-903

  • Hospital Universitario Clementino Fraga Filho

    Rio de Janeiro, 21941-617

  • Fundação Bahiana de Infectologia

    Salvador, Estado de Bahia, 40110160

  • CIP Centro Integrado de Pesquisas do Hospital de Base

    São José do Rio Preto, São Paulo, 15090-000

  • Assoc. Paulista para o Desenvolvimento da Medicina - UNIFESP

    São Paulo, São Paulo, 04024-002

  • Departamento de Gastroenterologia - HCFMUSP

    São Paulo, São Paulo, 05403-000

  • Rocco e Nazato Servicos Medicos LTDA

    São Paulo, 04077-020

Other trials in Brazil

France11 sites

  • Centre Hospitalier Universitaire D'Angers-1

    Angers, 49100

  • Centre Hospitalier Universitaire D'Angers

    Angers, 49100

  • Ap-Hp-Hopital Beaujon

    Clichy, 92110

  • Centre Hospitalier Universitaire de Lille-Hopital Claude Huriez

    Lille, 59000

  • Hospices Civils de Lyon-Hopital de La Croix Rousse

    Lyon, 69317

  • Centre Hospitalier Universitaire de Nice-Hopital de L'Archet

    Nice, 06200

  • APHP-HOPITAL LA PITIE SALPETRIERE_Service Hépato-Gastro-Enterologie

    Paris, 75013

  • Ap-Hp-Hopital Cochin

    Paris, 75014

  • Centre Hospitalier Universitaire de Bordeaux-Hopital Haut Leveque

    Pessac, 33600

  • Hospices Civils de Lyon-Hopital Lyon Sud

    Pierre-Bénite, 69310

  • Les Hopitaux Universitaires de Strasbourg-Hopital Civil

    Strasbourg, 67091

Other trials in France

Israel10 sites

  • Carmel MC - Liver Unit

    Haifa, 3434104

  • Carmel Medical Center Liver Unit

    Haifa, 3434104

  • Shaare Zedek MC - Liver Unit

    Jerusalem, 91031

  • Shaare Zedek Medical Center

    Jerusalem, 91031

  • Hadassah Ein Karam MC - Liver Unit

    Jerusalem, 91120

  • Western Galilee MC - Internal Medicine A

    Nahariya, 2210001

  • Liver Institute, Rabin Medical Center, Beilinson Campuse

    Petah Tikva, 49100

  • Rabin MC Beilinson - Liver Institute

    Petah Tikva, 49100

  • Sheba MC - Liver Diseases Center

    Ramat Gan, 52621

  • Sourasky MC - Liver Unit

    Tel Aviv, 64239

Other trials in Israel

Italy10 sites

  • Azieda Ospedaliero-Universitaria, Policlinico S. Orsola-Malp

    Bologna, 40138

  • Azienda Ospedaliero-Universitaria Renato Dulbecco

    Catanzaro, Cz, 88100

  • AOU Careggi Padiglione 16 San Luca, 3° piano

    Florence, 50134

  • Azienda Ospedaliero Universitaria Ospedali Riuniti - Foggia

    Foggia, 71122

  • Osp Magg Policlinico Centro Malattie metaboliche del Fegato

    Milan, 20122

  • AOUP Giaccone Palermo

    Palermo, Sicily, 90127

  • Fondazione Policlinico Universitario Agostino Gemelli IRCS

    Roma, 00168

  • Policlinico Università Campus Biomedico di Roma

    Rome, 00128

  • IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo

    San Giovanni Rotondo, Foggia, 71013

  • Città della salute e della scienza - university of Torino

    Torino, 10126

Other trials in Italy

Romania10 sites

  • Sana Monitoring SRL

    Bucharest, 011025

  • Hightech Medical Services S.R.L.

    Bucharest, 011053

  • Institutul Clinic Fundeni

    Bucharest, 022328

  • Spitalul Universitar de Urgenta Bucuresti

    Bucharest, 050098

  • Spitalul Clinic CF Cluj Napoca

    Cluj-Napoca, 400015

  • Institutul Gastroenterologie-Hepatologie Cluj-Napoca

    Cluj-Napoca, 400162

  • Gastroenterologie Spitalul Judetean Constanta

    Constanța, 900591

  • SC Diamed Obesity SRL

    Galati, 800291

  • Gastromedica

    Iași, 700506

  • Spital Judetean De Urgenta Satu Mare

    Satu Mare, 440055

Other trials in Romania

Spain10 sites

  • Hospital Vall d'Hebron

    Barcelona, 08035

  • Hospital Universitario Puerta de Hierro Majadahonda

    Majadahonda, 28222

  • Complejo Hospitalario de Pontevedra - Hospital de Montecelo

    Pontevedra, Galicia, 36004

  • Complejo Hospitalario de Pontevedra - Hospital de Montecelo

    Pontevedra, 36004

  • Hospital Universitario Marqués de Valdecilla

    Santander, 39008

  • Hospital Universitario Virgen del Rocío

    Seville, 41013

  • Hospital General de Valencia

    Valencia, 46014

  • Hospital Univ. y Politécnico La Fe

    Valencia, 46026

  • Hospital Universitario y Politécnico La Fe

    Valencia, 46026

  • Hospital Clínico de Valladolid

    Valladolid, 47010

Other trials in Spain

Taiwan10 sites

  • Ditmanson Medical Foundation Chia-Yi Christian Hospital

    Chiayi City, 600

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807

  • Taipei Tzu Chi Hospital

    New Taipei City, 231

  • China Medical University Hospital

    Taichung, 404

  • National Cheng Kung University Hospital

    Tainan, 704

  • National Taiwan University Hospital_main

    Taipei, 100

  • Taipei Mackay Memorial Hospital

    Taipei, 104

  • Cathay General Hospital

    Taipei, 106

  • Taipei Medical University Hospital

    Taipei, 110

  • Taipei-Veterans General Hospital - Dept of Gastrointestinal

    Taipei, 112

Other trials in Taiwan

Argentina9 sites

  • DIM Clinica Privada

    Buenos Aires, B1704ETD

  • Centro Médico Viamonte SRL

    CABA, C1120AAC

  • Hospital Italiano Departamento Hepatologia

    CABA, C1199ABH

  • Glenny Corp. S.A

    CABA, C1430CKE

  • Centro de Investigaciones Metabólicas

    Capital Federal, Buenos Aires, C1056ABI

  • Centro de Investigaciones Metabólicas

    Capital Federal, C1056ABJ

  • Hospital Britanico de Buenos Aires

    Ciudad de Buenos Aires, Buenos Aires, 1280

  • Hospital El Cruce

    Florencio Varela, Buenos Aires, 1888

  • Hospital del Centenario

    Rosario, Santa Fe, Santa Fe Province, S2002KDT

Other trials in Argentina

South Africa9 sites

  • Tiervlei Trial Centre

    Cape Town, Western Cape, 7530

  • Dr Rajabally's Practice

    Cape Town, Western Cape, 7800

  • Maxwell Centre

    Durban, KwaZulu-Natal, 4001

  • Lenmed Shifa Private Hospital

    Durban, KwaZulu-Natal, 4901

  • Chris Hani Baragwanath Hospital

    Johannesburg, Gauteng, 2013

  • WITS Clinical Research

    Johannesburg, Gauteng, 2193

  • Wits Health Consortium

    Johannesburg, 2193

  • Lenasia Clinical Trial Centre

    Lenasia, Gauteng, 1827

  • Phoenix Pharma

    Port Elizabeth, Eastern Cape, 6001

Other trials in South Africa

South Korea9 sites

  • Kyungpook National University Hospital

    Daegu, 41944

  • Yeungnam Univ. Medical Center

    Daegu, 42415

  • Keimyung University Dongsan Hospital

    Daegu, 42601

  • Wonju Severance Christian Hospital

    Gangwon-do, 26426

  • Soon Chun Hyang University Hospital Bucheon

    Gyeonggi-do, 14584

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722

  • Chung-Ang University Hospital

    Seoul, 06973

  • SMG-SNU Boramae Medical Center

    Seoul, 07061

  • Korea University Guro Hospital

    Seoul, 08308

Other trials in South Korea

Greece8 sites

  • Gen Hospital of Athens Ippokrateio,B' Uni Clinic of Inte Med

    Athens, 11527

  • Gen Hospital of Athens Laiko,1st Dpt. of Propaedeutic Inter

    Athens, 11527

  • General Hospital of Athens "LAIKO"

    Goudi, Athens, 115 27

  • Univ Gen Hospital of Ioannina,Gastroenterology-Endoscopy Uni

    Ioannina, 45500

  • Univ Gen Hospital Larisa, Cardiology Medicine Clinic

    Larissa, 41110

  • "AHEPA" University Hospital of Thessaloniki

    Thessaloniki, 54621

  • AHEPA General University Hospital

    Thessaloniki, 54636

  • General Hospital of Thessaloniki "Ippokrateio"

    Thessaloniki, 54642

Other trials in Greece

Mexico8 sites

  • Centro de Investigacion Clinica del Pacifico, S.A. de C.V.

    Acapulco de Juárez, Guerrero, 39670

  • Hospital Angeles de Culiacan

    Culiacán, Sinaloa, 80020

  • Centro de Investigación Médico Biológica y Terapia

    Guadalajara, Jalisco, 44130

  • Medical Care and Research S. A de C.V

    Mérida, Yucatán, 97070

  • Centro de Investigación y Gastroenterología_ Hospital Angeles Universidad

    México, 03330

  • Centro de Investigación y Gastroenterología, S.C.

    Mexico City, México, D.F., 06700

  • Investigaciones Médicas Cisneros, S.C.

    Monterrey, Nuevo León, 64000

  • Servicios de Oncologia Medica Integral S.A de C.V (ONCARE)

    San Pedro Garza García, Nuevo León, 66220

Other trials in Mexico

Croatia7 sites

  • Klinicki bolnicki centar Osijek_Endocrinology

    Osijek, 31 000

  • Klinicki bolnicki centar Osijek

    Osijek, 31 000

  • KBC Rijeka, Zavod za gastroenterologiju

    Rijeka, 51000

  • KBC Split/ Firule/ Gastroenterologija

    Split, 21000

  • KBC Split_Gastroenterology

    Split, 21000

  • KB Dubrava, Zavod za gastroenterologiju

    Zagreb, 10000

  • Klinički bolnički centar Zagreb, Zavod za gastroenterologiju

    Zagreb, 10000

Other trials in Croatia

Poland7 sites

  • Gizinscy Centrum Medyczne

    Bydgoszcz, 85-676

  • ID Clinic Arkadiusz Pisula

    Myslowice, Lesser Poland Voivodeship, 41-400

  • Ko-Med Centra Kliniczne Staszow

    Staszów, Świętokrzyskie Voivodeship, 28-200

  • Velocity Nova Sp. z o.o.

    Staszów, Świętokrzyskie Voivodeship, 28-200

  • Bodyclinic Sp. z o.o. sp.k.

    Warsaw, 03-712

  • Centrum Badan Klinicznych

    Wroclaw, 51-162

  • FutureMeds Sp. z o.o.

    Wroclaw, 53-673

Other trials in Poland

Belgium6 sites

  • CUB Hôpital Erasme_Brussels_0

    Brussels, 1070

  • Cliniques Universitaires Saint-Luc - Serv. Hépato-gastroentérology

    Brussels, 1200

  • UZA

    Edegem, 2650

  • Ziekenhuis Oost-Limburg AV - Gastro

    Genk, 3600

  • AZ Maria Middelares - Gent - Gastro-Enterology

    Ghent, 9000

  • UZ Gent - Department Gastro-enterology

    Ghent, 9000

Other trials in Belgium

Austria5 sites

  • Klin.Abt. f. Gastroenterologie u. Hepatologie

    Graz, 8036

  • Fließer-Görzer [Ordination]

    Saint Stefan, 8511

  • LKH Salzburg Universitätsklinikum

    Salzburg, 5020

  • Klinik Landstraße

    Vienna, 1030

  • Klinikum Wels-Grieskirchen

    Wels, 4600

Other trials in Austria

Singapore5 sites

  • National University Hospital Singapore_Tahir Building

    Singapore, 119228

  • National University Hospital_Tahir Building

    Singapore, 119228

  • Singapore General Hospital

    Singapore, 169608

  • Changi General Hospital

    Singapore, 529889

  • Changi General Hospital

    Singapore, 529905

Other trials in Singapore

Slovakia5 sites

  • Nemocnica akademika L. Derera, UNB

    Bratislava, 833 05

  • MEDISPEKTRUM s.r.o.

    Bratislava, 851 01

  • II. Interna klinika, Univerzitna nemocnica L. Pasteura Kosice

    Košice, 040 11

  • Hepatobiliarne centrum - Michalovce

    Michalovce, 071 01

  • JAL s.r.o.

    Trnava, 91701

Other trials in Slovakia

Switzerland5 sites

  • Universitätsklinik für Viszerale Chirurgie und Medizin

    Bern, 3010

  • Hôpitaux Universitaires de Genève

    Geneva, 1211

  • Kantonsspital Olten

    Olten, 4600

  • Kantonsspital St. Gallen

    Sankt Gallen, 9007

  • USZ Klinik für Gastroenterologie und Hepatologie

    Zurich, 8091

Other trials in Switzerland

Denmark4 sites

  • Aarhus Universitetshospital Skejby Mave-Tarm

    Aarhus N, 8200

  • Hvidovre Hospital - Gastroenheden

    Hvidovre, 2650

  • Bispebjerg Hospital - Abdominal Center K, Research Unit

    København NV, 2400

  • Odense University Hospital - FLASH - Centre for Liver Research

    Odense C, 5000

Other trials in Denmark

Malaysia4 sites

  • Hospital Selayang

    Batu Caves, 68100

  • Hospital Universiti Sains Malaysia

    Kota Bharu, Kelantan, 16150

  • University Malaya Medical Centre

    Kuala Lumpur, Kuala Lumpur, 59100

  • University Malaya Medical Centre

    Lembah Pantai, Kuala Lumpur, 59100

Other trials in Malaysia

Netherlands4 sites

  • Noordwest Ziekenhuisgroep

    Alkmaar, 1815 JD

  • AmsterdamUMC AMC

    Amsterdam, 1105 AZ

  • Leids Universitair Medisch Centrum

    Leiden, 2333 ZA

  • Franciscus Gasthuis en Vlietland

    Rotterdam, 3045 PM

Other trials in Netherlands

Serbia4 sites

  • Clinic for gastroenterology and hepatology

    Belgrade, 11000

  • Endocrinology, Diabetes and Metabolism Diseases Clinic

    Belgrade, 11000

  • Clinical-hospital centre Zvezdara

    Belgrade, 11020

  • Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.

    Novi Sad, Vojvodina, 21000

Other trials in Serbia

Czechia3 sites

  • Krajská nemocice Liberec, a.s

    Liberec, 460 01

  • Researchsite s.r.o.

    Pilsen, 301 00

  • Vseobecna Fakultni nemocnice v Praze

    Prague, 128 08

Other trials in Czechia

Norway3 sites

  • Bærum sykehus - Vestre Viken HF

    Gjettum, 1346

  • Bærum sykehus

    Gjettum, 1346

  • Oslo universitetssykehus, Ullevål

    Oslo, 0450

Other trials in Norway

Ireland2 sites

  • Hepatology St James's

    Dublin, D08 NHY1

  • Beaumont Hospital Hepatology Dept

    Dublin, D09V2N0

Other trials in Ireland

Puerto Rico1 site

  • FDI Clinical Research

    San Juan, 00927

Other trials in Puerto Rico

About this study

Official title: The Effect of Semaglutide in Subjects With Non-cirrhotic Non-alcoholic Steatohepatitis

Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries.

Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance.

Read more

Participants will need to inject themselves with medicine under the skin. Participants will need to do this once a week.

The study will last for about 5 years. Participants will have up to 21 clinic visits and 9 phone calls with the clinical staff during the study. Some of the clinic visits may be spread over more than one day.

Participants with other chronic liver diseases cannot take part in this study. Women cannot take part in the study if they are pregnant, breast-feeding or plan to become pregnant during the study period.

Being tested
Semaglutide, Placebo
Medical subject headings
Non-alcoholic Fatty Liver Disease

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • SemaglutideDrug

    Semaglutide administrated subcutaneously (under the skin) once weekly there will be a period of dose escalation before reaching the target dose.

  • PlaceboDrug

    Placebo administrated subcutaneously (under the skin) once weekly.

Study groups in NCT04822181
Study groupRoleWhat they receive
Semaglutide OW (once weekly )ExperimentalSemaglutide administrated subcutaneously once weekly
Receives: Drug: Semaglutide
PlaceboPlacebo comparatorPlacebo administrated subcutaneously once weekly
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Part 1: Resolution of steatohepatitis and no worsening of liver fibrosis (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 72

  2. Part 1: Improvement in liver fibrosis and no worsening of steatohepatitis (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 72

  3. Part 2: Cirrhosis-free survival (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 240

Secondary outcomes (35)

  1. Change in body weight

    Percentage

    Measured: From randomisation (week 0) to week 72

  2. Resolution of steatohepatitis and improvement in liver fibrosis (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 72

  3. Change in SF-36 (Short Form 36) Bodily Pain

    Score points

    Measured: From randomisation (week 0) to week 72

  4. Change in body weight

    Percentage

    Measured: From randomisation (week 0) to week 240

  5. Improvement in steatohepatitis with at least a 2-point reduction in NAS and no worsening of fibrosis (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 72

  6. Change in histology-assessed liver collagen proportionate area

    Ratio to baseline

    Measured: From randomisation (week 0) to week 72

  7. Worsening in steatohepatitis (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 72

  8. Improvement in histology-assessed ballooning (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 72

  9. Improvement in histology-assessed inflammation (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 72

  10. Improvement in histology-assessed steatosis (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 72

  11. NASH resolution (ballooning of 0, inflammation of 0-1) and above or equal to 2point NAS reduction with no worsening of fibrosis

    Count of subject

    Measured: From randomisation (week 0) to week 72

  12. Progression of liver fibrosis in patients with F2 at baseline (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 72

  13. Progression of liver fibrosis

    Count of subject

    Measured: From randomisation (week 0) to week 72

  14. Resolution of steatohepatitis and no worsening of liver fibrosis (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 240

  15. Improvement in liver fibrosis and no worsening of steatohepatitis (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 240

  16. Absence of histological evidence of NASH (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 240

  17. Changes in liver stiffness values assessed by transient elastography (FibroScan®)

    Ratio to baseline

    Measured: From randomisation (week 0) to week 72 and week 240

  18. Change in ELF (Enhanced Liver Fibrosis) score

    Logarithm

    Measured: From randomisation (week 0) to week 72 and week 240

  19. Change in ALT (alanine aminotransferase)

    Ratio to baseline

    Measured: From randomisation (week 0) to week 72 and week 240

  20. Change in AST (aspartate aminotransferase)

    Ratio to baseline

    Measured: From randomisation (week 0) to week 72 and week 240

  21. Change in CAP (Controlled Attenuation Parameter) values assessed by transient elastography (FibroScan)

    Absolute change

    Measured: From randomisation (week 0) to week 72 and week 240

  22. Change in FAST (FibroScan-AST) score

    Probability (absolute change)

    Measured: From randomisation (week 0) to week 72 and week 240

  23. Change in Pro-C3 (pro-peptide of type III collagen)

    Logarithm

    Measured: From randomisation (week 0) to week 72 and week 240

  24. Change in inflammation assessed by hsCRP (High Sensitive C-Reactive Protein)

    Ratio to baseline

    Measured: From randomisation (week 0) to week 72 and week 240

  25. Change in HbA1c (glycated haemoglobin)

    Percentage-points (absolute change)

    Measured: From randomisation (week 0) to week 72 and week 240

  26. Change in triglyceride

    Ratio to baseline

    Measured: From randomisation (week 0) to week 72 and week 240

  27. Change in free fatty acids

    Ratio to baseline

    Measured: From randomisation (week 0) to week 72 and week 240

  28. Change in LDL (low-density lipoprotein) cholesterol

    Ratio to baseline

    Measured: From randomisation (week 0) to week 72 and week 240

  29. Change in HDL (High density lipoprotein ) cholesterol

    Ratio to baseline

    Measured: From randomisation (week 0) to week 72 and week 240

  30. Time to first MACE(Major Adverse Cardiovascular event ) (composite endpoint)

    Days

    Measured: From randomisation (week 0) to week 240

  31. Major cardio-hepatic event-free survival (Yes/No)

    Count of subject

    Measured: From randomisation (week 0) to week 240

  32. Changes in SF-36 (Short Form 36 v2.0 acute ) Physical Component Summary

    Score points

    Measured: From randomisation (week 0) to week 72 and week 240

  33. Changes in SF-36 Mental Component Summary

    Score points

    Measured: From randomisation (week 0) to week 72 and week 240

  34. Change in SF-36 Bodily Pain

    Score points

    Measured: From randomisation (week 0) to week 240

  35. Changes in NASH-CHECK Abdominal Pain

    Score points

    Measured: From randomisation (week 0) to week 72 and week 240

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted30 Mar 2021
  2. Study start1 Apr 2021
  3. Primary completion25 Apr 2029 (estimated)
  4. Study completion25 Apr 2029 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
1,205 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT04822181
Sponsor's protocol ID
NN9931-4553
Other IDs
U1111-1244-3678, 2019-004594-44, jRCT2031210033, 2019
Acronym
ESSENCE
Status last verified
Oct 2026
First submitted
26 Mar 2021
Last updated
13 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

Publications

  • Newsome PN, Sanyal AJ, Engebretsen KA, Kliers I, Ostergaard L, Vanni D, Bugianesi E, Rinella ME, Roden M, Ratziu V. Semaglutide 2.4 mg in Participants With Metabolic Dysfunction-Associated Steatohepatitis: Baseline Characteristics and Design of the Phase 3 ESSENCE Trial. Aliment Pharmacol Ther. 2024 Dec;60(11-12):1525-1533. doi: 10.1111/apt.18331. Epub 2024 Oct 16.

    PubMed 39412509

  • Nakajima A, Okanoue T, Hiasa Y, Takahashi H, Opuni K, Kosaka N, Nishida T, Sanyal AJ. Semaglutide in Japanese participants with metabolic dysfunction-associated steatohepatitis: a subgroup analysis of the ESSENCE trial. J Gastroenterol. 2026 Aug 28. doi: 10.1007/s00535-026-02507-0. Online ahead of print.

    PubMed 42663669

  • Sanyal AJ, Newsome PN, Kliers I, Ostergaard LH, Long MT, Kjaer MS, Cali AMG, Bugianesi E, Rinella ME, Roden M, Ratziu V; ESSENCE Study Group. Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis. N Engl J Med. 2025 Jun 5;392(21):2089-2099. doi: 10.1056/NEJMoa2413258. Epub 2025 Apr 30.

    PubMed 40305708

  • Jensen EL, Israelsen M, Krag A. Transforming steatotic liver disease management: The emerging role of GLP-1 receptor agonists. Hepatol Commun. 2024 Oct 10;8(11):e0561. doi: 10.1097/HC9.0000000000000561. eCollection 2024 Nov 1.

    PubMed 39392766

  • Rowe IA, Allen AM. Hepatic steatosis provides the terroir that promotes the development of cardiovascular risk factors and disease. Hepatology. 2023 Jun 1;77(6):1843-1845. doi: 10.1097/HEP.0000000000000327. Epub 2023 Feb 6. No abstract available.

    PubMed 36738088

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Semaglutide in people with Non-alcoholic Steatohepatitis, run by Novo Nordisk A/S at 558 sites in 39 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 13 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 558 sites in United States, Japan, China, United Kingdom, India and 34 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Part 1: Resolution of steatohepatitis and no worsening of liver fibrosis (Yes/No) (time frame: From randomisation (week 0) to week 72). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT04822181, which also lists 5 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Oct 2026.

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