Skeletal Muscle DamageNCT04795232
Recovery Kinetics Following Change of Direction Training
A study testing COD45 and COD90 in people with Skeletal Muscle Damage, run by University of Thessaly at 2 sites in Greece.
Trial summary
This study aims at investigating the recovery kinetics of skeletal muscle damage, neuromuscular fatigue and performance following a single change of direction (COD) training session in competitive soccer players. The impact of COD degrees will be also examined by comparing a 45o vs. 90o COD training session. Read more about this study
- Who is it for?
- Ages 18 to 35 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Skeletal Muscle Damage
- What is being tested?
- COD45 and COD90
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 2 sitesGreece
- Study dates
- 1 Apr 2021to 30 Jun 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Soccer players participating in at least 5 training sessions per week and 1official match
- Participation at a competitive level for at least 4 years
- Free of musculoskeletal injuries
- No use of ergogenic supplements or medication
- Non-smokers
Who cannot join
- Musculoskeletal injury
- Use of alcohol, caffeine and any type of ergogenic supplements or medication during the course of the study
Trial locations and contacts
2 sites in 1 country.
Greece2 sites
SMART LAB, Department of Physical Education and Sports Science, University of Thessaly.
Trikala, 42100
SmArT LABORATORY, SCHOOL OF PHYSICAL EDUCATION & SPORTS SCIENCES, UNIVERSITY OF THESSALY
Trikala, 42100
About this study
Official title: Recovery Kinetics Following Change of Direction (COD) Training in Soccer: Implications for Different COD Angles
This study aims at investigating the recovery kinetics of skeletal muscle damage, neuromuscular fatigue and performance following a single change of direction (COD) training session in competitive soccer players. The impact of COD degrees will be also examined by comparing a 45o vs. 90o COD training session. Ten male soccer players will perform a COD45 [A single training session including 2x(10x ~27.6m) sprints with two 45o COD in each sprint], a COD90 [A single training session including 2x(10x ~21.2m) sprints with two 90o COD in each sprint] and a Control trial (No intervention included, only daily measurements) in randomized, repeated measures, crossover design. Assessments related to skeletal muscle damage, neuromuscular fatigue and performance will be performed prior to training session and daily for three consecutive days post-training, in each trial.
Read the detailed description
Ten male soccer players will be included in this study. Participants will be initially informed about the aim of study as well as the associated risks and benefits and subsequently will provide their signed consent form. At baseline, they will undergo assessment of their anthropometrics (i.e. body mass and body height), body composition (by DXA), physical conditioning status [maximal oxygen consumption (VO2max), Yo-Yo Intermittent Endurance test level 2 and Yo-Yo Intermittent Recovery test level 2] and daily dietary intake. Thereafter, they will participate in two experimental trials and one control trial in a randomized, crossover, repeated measures design: i) COD45: Participants in this trial will perform a COD training session consisted of 2 sets of 10 x ~27.6m sprints with two 45o COD in each sprint and a resting period of 16 sec and 2:20 min between sprints and sets, respectively, ii) COD90: Participants in this trial will perform a COD training session consisted of 2 sets of 10 x ~21.2m sprints with two 90o COD in each sprint and a resting period of 16 sec and 2:20 min between sprints and sets, respectively, iii) Control: Participants in this trial will only participate in daily assessments to control for day to day variability in the depended variables (they will not receive any intervention). Prior to each trial, participants will provide a resting blood sample (for the determination of blood lactate, white blood cell count and creatine kinase activity) and undergo assessment of their delayed onset of muscle soreness (DOMS), maximal voluntary isometric contraction (MVIC), countermovement jump [will be assessed using two force platforms at 1000 Hz and electromyography instrumentation (EMG)], isokinetic peak torque of knee extensors and flexors (will be assessed on an isokinetic dynamometer), agility (will be assessed using the Illinois test), 10m and 30m sprint time (will be assessed by using light cells) and repeated sprint ability (5x30m sprints will be performed with 25 sec rest in-between). In COD45 and COD90 experimental trials, a blood sample will be collected immediately post-training for the determination of blood lactate concentration while assessment of DOMS, MVIC and countermovement jump will be performed at 1, 2 and 3 hours post-training. In all trials assessment of DOMS, MVIC, countermovement jump (CMJ), isokinetic peak torque, agility and sprinting performance as well as determination of creatine kinase activity and white blood cell count will be performed at 24, 48 and 72 hours post-training. A 7-day wash out period will applied between trials.
- Conditions
- Skeletal Muscle Damage
- Being tested
- COD45, COD90
- Keywords
- change of direction training, recovery, soccer, performance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
COD45Other
Participants will perform 2 sets of 10 sprints. The total distance for each sprint will be 27.6 meters and will include two changes of direction of 45 degrees. The recovery time will be 16 seconds between sprints and 2.20 minutes between sets
COD90Other
Participants will perform 2 sets of 10 sprints. The total distance for each sprint will be 21.2 meters and will include two changes of direction of 90 degrees. The recovery time will be 16 seconds between sprints and 2.20 minutes between sets
| Study group | Role | What they receive |
|---|---|---|
| Control | No intervention | Participants in this arm will receive no intervention |
| COD45 | Experimental | Participants in this arm will participate in a COD training session consisted of 45 degrees changes of direction Receives: Other: COD45 |
| COD90 | Experimental | Participants in this arm will participate in a COD training session consisted of 90 degrees changes of direction Receives: Other: COD90 |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in creatine kinase activity
Creatine kinase activity will be measured in plasma
Measured: At baseline, at 24, 48 and 72 hours after change of direction training session
Change in white blood cell count
White blood cell count will be measured by using an automatic blood analyzer
Measured: At baseline, at 24, 48 and 72 hours after change of direction training session
Change in delayed onset of muscle soreness
Muscle soreness will be assessed by palpation of the muscle belly and the distal region
Measured: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Change in isometric peak torque
Isometric peak torque will be assessed on an isokinetic dynamometer
Measured: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Change in fatigue index of maximal voluntary isometric contraction during 10 seconds
Fatigue rate will be determined by calculating the percent drop of peak torque between the first and the last three seconds of a 10-second maximal isometric contraction
Measured: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Change in isokinetic peak torque of knee extensors
Isokinetic peak torque will be assessed on an isokinetic dynamometer in both limbs
Measured: At baseline, at 24, 48 and 72 hours after change of direction training session
Change in isokinetic peak torque of knee flexors
Isokinetic peak torque will be assessed on an isokinetic dynamometer in both limbs
Measured: At baseline, at 24, 48 and 72 hours after change of direction training session
Change in countermovement jump height
Countermovement jump height will be assessed by using two force platforms at 1000 Hz, with each foot in parallel on the two platforms providing a separate yet time-synchronized measurement of the jump height for each leg
Measured: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Change in ground reaction force during countermovement jump
Ground reaction force will be assessed by using two force platforms at 1000 Hz, with each foot in parallel on the two platforms providing a separate yet time-synchronized measurement of the jump height for each leg
Measured: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Change in peak power during countermovement jump
Peak power will be assessed using two force platforms at 1000 Hz, with each foot in parallel on the two platforms providing a separate yet time-synchronized measurement of the jump height for each leg
Measured: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Change in mean power during countermovement jump
Mean power will be assessed using two force platforms at 1000 Hz, with each foot in parallel on the two platforms providing a separate yet time-synchronized measurement of the jump height for each leg
Measured: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Change in vertical stiffness during countermovement jump
Vertical stiffness will be assessed using two force platforms at 1000 Hz, with each foot in parallel on the two platforms providing a separate yet time-synchronized measurement of the jump height for each leg
Measured: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Change in peak rate of force development during countermovement jump
Peak rate of force development will be assessed using two force platforms at 1000 Hz, with each foot in parallel on the two platforms providing a separate yet time-synchronized measurement of the jump height for each leg
Measured: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Change in peak normalized electromyography (EMG) during the eccentric and concentric phases of the countermovement jump
EMG data will be collected wirelessly at 2000 Hz using a Myon MA-320 EMG system (Myon AG, Switzerland) for the vastus lateralis, biceps femoris, gastrocnemius and gluteus maximus muscles.
Measured: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Change in mean normalized electromyography (EMG) during the eccentric and concentric phases of the countermovement jump
EMG data will be collected wirelessly at 2000 Hz using a Myon MA-320 EMG system (Myon AG, Switzerland) for the vastus lateralis, biceps femoris, gastrocnemius and gluteus maximus muscles.
Measured: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Change in repeated sprint ability
Repeated sprint ability will be tested using 5x30 m sprints with 25 seconds rest in-between
Measured: At baseline, at 24, 48 and 72 hours after change of direction training session
Change in sprint time of 10m
10m sprint time will be assessed using light cells
Measured: At baseline, at 24, 48 and 72 hours after change of direction training session
Change in sprint time of 30m
30m sprint time will be assessed using light cells
Measured: At baseline, at 24, 48 and 72 hours after change of direction training session
Change in agility
Agility will be assessed using the illinois agility test.
Measured: At baseline, at 24, 48 and 72 hours after change of direction training session
Change in field activity during the change of direction training session
Field activity will be continuously monitored during the change of direction training session by using global positioning system (GPS)
Measured: During the change of direction training session
Change in heart rate during the change of direction training session
Heart rate will be continuously monitored during the change of direction training session by using heart rate monitors.
Measured: During the change of direction training session
Change in blood lactate concentration
Blood lactate will be measured using a lactate plus system
Measured: At baseline and immediately post change of direction training session
Secondary outcomes (8)
Body mass
Body mass will me measured on a beam balance with stadiometer
Measured: At baseline
Body height
Body height will me measured on a beam balance with stadiometer
Measured: At baseline
Body fat
Body fat will be assessed by using Dual-emission X-ray absorptiometry
Measured: At baseline
Lean body mass
Lean body mass will be assessed by using Dual-emission X-ray absorptiometry
Measured: At baseline
Maximal oxygen consumption (VO2max)
VO2max will be measured by open circuit spirometry via breath by breath method
Measured: At baseline
Yo-Yo Intermittent Endurance Test level 2 performance
Measured: At baseline
Yo-Yo Intermittent Recovery Test level 2 performance
Measured: At baseline
Dietary intake
Dietary intake will be assessed over a 7-day period by using diet recalls
Measured: At baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Mar 2021
- Study start1 Apr 2021
- Primary completion30 Sep 2021
- Study completion30 Jun 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Skeletal Muscle DamageStudies of the same condition, open and under way.
- More trials run by University of ThessalyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 10 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Thessaly
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ioannis G. Fatouros, University of Thessaly
- Investigators
- Ioannis G Fatouros, Prof, Study director, University of Thessaly, Department of Physical Education and Sport Science
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04795232
- Sponsor's protocol ID
- Recovery-COD Training-UTH
- Status last verified
- Oct 2023
- First submitted
- 9 Mar 2021
- Last updated
- 10 Oct 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Poulios A, Grammenos N, Fatouros IG, Avloniti A, Tsimeas P, Papanikolaou K, Syrou N, Rosvoglou A, Tsaousidis I, Chatzinikolaou A, Tsiokanos A, Mohr M, Jamurtas AZ, Draganidis D. Recovery Kinetics After Repeated Sprint Training With Directional Changes in Soccer: It Is a Matter of Angle. J Strength Cond Res. 2026 May 15. doi: 10.1519/JSC.0000000000005526. Online ahead of print.
PubMed 42133376
Study at a glance
From the registry record, last updated by the sponsor on 10 Oct 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Recovery Kinetics Following Change of Direction (COD) Training in Soccer: Implications for Different COD Angles
- ClinicalTrials.gov ID
- NCT04795232
- Acronym / sponsor ID
- Recovery-COD Training-UTH
- Conditions
- Skeletal Muscle Damage
- Keywords
- change of direction training, recovery, soccer, performance
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 10 participants (actual)
- Lead sponsor
- University of ThessalyUniversity, hospital or other
- Study start
- 1 Apr 2021 (actual)
- Primary completion
- 30 Sep 2021 (actual)
- Study completion
- 30 Jun 2023 (actual)
- First posted
- 12 Mar 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims at investigating the recovery kinetics of skeletal muscle damage, neuromuscular fatigue and performance following a single change of direction (COD) training session in competitive soccer players. The impact of COD degrees will be also examined by comparing a 45o vs. 90o COD training session. Ten male soccer players will perform a COD45 [A single training session including 2x(10x ~27.6m) sprints with two 45o COD in each sprint], a COD90 [A single training session including 2x(10x ~21.2m) sprints with two 90o COD in each sprint] and a Control trial (No intervention included, only daily measurements) in randomized, repeated measures, crossover design. Assessments related to skeletal muscle damage, neuromuscular fatigue and performance will be performed prior to training session and daily for three consecutive days post-training, in each trial.
Detailed description
Ten male soccer players will be included in this study. Participants will be initially informed about the aim of study as well as the associated risks and benefits and subsequently will provide their signed consent form. At baseline, they will undergo assessment of their anthropometrics (i.e. body mass and body height), body composition (by DXA), physical conditioning status [maximal oxygen consumption (VO2max), Yo-Yo Intermittent Endurance test level 2 and Yo-Yo Intermittent Recovery test level 2] and daily dietary intake. Thereafter, they will participate in two experimental trials and one control trial in a randomized, crossover, repeated measures design: i) COD45: Participants in this trial will perform a COD training session consisted of 2 sets of 10 x ~27.6m sprints with two 45o COD in each sprint and a resting period of 16 sec and 2:20 min between sprints and sets, respectively, ii) COD90: Participants in this trial will perform a COD training session consisted of 2 sets of 10 x ~21.2m sprints with two 90o COD in each sprint and a resting period of 16 sec and 2:20 min between sprints and sets, respectively, iii) Control: Participants in this trial will only participate in daily assessments to control for day to day variability in the depended variables (they will not receive any intervention). Prior to each trial, participants will provide a resting blood sample (for the determination of blood lactate, white blood cell count and creatine kinase activity) and undergo assessment of their delayed onset of muscle soreness (DOMS), maximal voluntary isometric contraction (MVIC), countermovement jump [will be assessed using two force platforms at 1000 Hz and electromyography instrumentation (EMG)], isokinetic peak torque of knee extensors and flexors (will be assessed on an isokinetic dynamometer), agility (will be assessed using the Illinois test), 10m and 30m sprint time (will be assessed by using light cells) and repeated sprint ability (5x30m sprints will be performed with 25 sec rest in-between). In COD45 and COD90 experimental trials, a blood sample will be collected immediately post-training for the determination of blood lactate concentration while assessment of DOMS, MVIC and countermovement jump will be performed at 1, 2 and 3 hours post-training. In all trials assessment of DOMS, MVIC, countermovement jump (CMJ), isokinetic peak torque, agility and sprinting performance as well as determination of creatine kinase activity and white blood cell count will be performed at 24, 48 and 72 hours post-training. A 7-day wash out period will applied between trials.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Control | No intervention | –Participants in this arm will receive no intervention |
| COD45 | Experimental | Other: COD45Participants in this arm will participate in a COD training session consisted of 45 degrees changes of direction |
| COD90 | Experimental | Other: COD90Participants in this arm will participate in a COD training session consisted of 90 degrees changes of direction |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Soccer players participating in at least 5 training sessions per week and 1official match
- Participation at a competitive level for at least 4 years
- Free of musculoskeletal injuries
- No use of ergogenic supplements or medication
- Non-smokers
Key exclusion criteria (2 listed)
- Musculoskeletal injury
- Use of alcohol, caffeine and any type of ergogenic supplements or medication during the course of the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| COD45Participants will perform 2 sets of 10 sprints. The total distance for each sprint will be 27.6 meters and will include two changes of direction of 45 degrees. The recovery time will be 16 seconds between sprints and 2.20 minutes between sets | Other | COD45 |
| COD90Participants will perform 2 sets of 10 sprints. The total distance for each sprint will be 21.2 meters and will include two changes of direction of 90 degrees. The recovery time will be 16 seconds between sprints and 2.20 minutes between sets | Other | COD90 |
Primary outcome
Change in creatine kinase activity
Time frame: At baseline, at 24, 48 and 72 hours after change of direction training session
Creatine kinase activity will be measured in plasma
Change in white blood cell count
Time frame: At baseline, at 24, 48 and 72 hours after change of direction training session
White blood cell count will be measured by using an automatic blood analyzer
Change in delayed onset of muscle soreness
Time frame: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Muscle soreness will be assessed by palpation of the muscle belly and the distal region
Change in isometric peak torque
Time frame: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Isometric peak torque will be assessed on an isokinetic dynamometer
Change in fatigue index of maximal voluntary isometric contraction during 10 seconds
Time frame: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Fatigue rate will be determined by calculating the percent drop of peak torque between the first and the last three seconds of a 10-second maximal isometric contraction
Change in isokinetic peak torque of knee extensors
Time frame: At baseline, at 24, 48 and 72 hours after change of direction training session
Isokinetic peak torque will be assessed on an isokinetic dynamometer in both limbs
Change in isokinetic peak torque of knee flexors
Time frame: At baseline, at 24, 48 and 72 hours after change of direction training session
Isokinetic peak torque will be assessed on an isokinetic dynamometer in both limbs
Change in countermovement jump height
Time frame: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Countermovement jump height will be assessed by using two force platforms at 1000 Hz, with each foot in parallel on the two platforms providing a separate yet time-synchronized measurement of the jump height for each leg
Change in ground reaction force during countermovement jump
Time frame: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Ground reaction force will be assessed by using two force platforms at 1000 Hz, with each foot in parallel on the two platforms providing a separate yet time-synchronized measurement of the jump height for each leg
Change in peak power during countermovement jump
Time frame: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Peak power will be assessed using two force platforms at 1000 Hz, with each foot in parallel on the two platforms providing a separate yet time-synchronized measurement of the jump height for each leg
Change in mean power during countermovement jump
Time frame: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Mean power will be assessed using two force platforms at 1000 Hz, with each foot in parallel on the two platforms providing a separate yet time-synchronized measurement of the jump height for each leg
Change in vertical stiffness during countermovement jump
Time frame: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Vertical stiffness will be assessed using two force platforms at 1000 Hz, with each foot in parallel on the two platforms providing a separate yet time-synchronized measurement of the jump height for each leg
Change in peak rate of force development during countermovement jump
Time frame: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
Peak rate of force development will be assessed using two force platforms at 1000 Hz, with each foot in parallel on the two platforms providing a separate yet time-synchronized measurement of the jump height for each leg
Change in peak normalized electromyography (EMG) during the eccentric and concentric phases of the countermovement jump
Time frame: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
EMG data will be collected wirelessly at 2000 Hz using a Myon MA-320 EMG system (Myon AG, Switzerland) for the vastus lateralis, biceps femoris, gastrocnemius and gluteus maximus muscles.
Change in mean normalized electromyography (EMG) during the eccentric and concentric phases of the countermovement jump
Time frame: At baseline, at 1, 2, 3, 24, 48 and 72 hours after change of direction training session
EMG data will be collected wirelessly at 2000 Hz using a Myon MA-320 EMG system (Myon AG, Switzerland) for the vastus lateralis, biceps femoris, gastrocnemius and gluteus maximus muscles.
Change in repeated sprint ability
Time frame: At baseline, at 24, 48 and 72 hours after change of direction training session
Repeated sprint ability will be tested using 5x30 m sprints with 25 seconds rest in-between
Change in sprint time of 10m
Time frame: At baseline, at 24, 48 and 72 hours after change of direction training session
10m sprint time will be assessed using light cells
Change in sprint time of 30m
Time frame: At baseline, at 24, 48 and 72 hours after change of direction training session
30m sprint time will be assessed using light cells
Change in agility
Time frame: At baseline, at 24, 48 and 72 hours after change of direction training session
Agility will be assessed using the illinois agility test.
Change in field activity during the change of direction training session
Time frame: During the change of direction training session
Field activity will be continuously monitored during the change of direction training session by using global positioning system (GPS)
Change in heart rate during the change of direction training session
Time frame: During the change of direction training session
Heart rate will be continuously monitored during the change of direction training session by using heart rate monitors.
Change in blood lactate concentration
Time frame: At baseline and immediately post change of direction training session
Blood lactate will be measured using a lactate plus system
8 secondary outcomes
Body mass
Time frame: At baseline
Body height
Time frame: At baseline
Body fat
Time frame: At baseline
Lean body mass
Time frame: At baseline
Maximal oxygen consumption (VO2max)
Time frame: At baseline
Yo-Yo Intermittent Endurance Test level 2 performance
Time frame: At baseline
Yo-Yo Intermittent Recovery Test level 2 performance
Time frame: At baseline
Dietary intake
Time frame: At baseline
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Oct 2023.
- Derived from this study: PubMed 42133376Poulios A, Grammenos N, Fatouros IG, Avloniti A, Tsimeas P, Papanikolaou K, Syrou N, Rosvoglou A, Tsaousidis I, Chatzinikolaou A, Tsiokanos A, Mohr M, Jamurtas AZ, Draganidis D. Recovery Kinetics After Repeated Sprint Training With Directional Changes in Soccer: It Is a Matter of Angle. J Strength Cond Res. 2026 May 15. doi: 10.1519/JSC.0000000000005526. Online ahead of print.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ioannis G Fatouros, Prof study director
University of Thessaly, Department of Physical Education and Sport Science
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing COD45 and COD90 in people with Skeletal Muscle Damage, run by University of Thessaly at 2 sites in Greece.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Oct 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Greece. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in creatine kinase activity (time frame: At baseline, at 24, 48 and 72 hours after change of direction training session). The study lists 22 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04795232, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Oct 2023.