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Solid TumorPhase 1NCT04710043

Dose Escalation Trial of BNT152+153 in Patients With Cancer

A Phase 1 study testing BNT152 and BNT153 in people with Solid Tumor, run by BioNTech SE at 7 sites in 2 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This is an open-label, multisite Phase I dose escalation, safety, pharmacokinetics (PK) and pharmacodynamics (PD) trial of BNT152+153 in various solid tumor indications. The clinical trial will enroll patients with various solid tumors that are metastatic or unresectable for whom there is no available standard therapy… Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Solid Tumor
What is being tested?
BNT152 and BNT153
Type of treatment
Injection or infusion
Could I receive a placebo?
No, everyone receives an active treatment
How many people
86 participants
Where
7 sitesin 2 countries
Study dates
8 Jun 2021to 10 Sep 2025
Phase
Phase 1
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Histologically or cytologically confirmed solid tumor that is metastatic (Stage IV) or unresectable and for whom there is no available standard therapy likely to confer clinical benefit, or patient who is not a candidate for such available therapy. If there is no contraindication, patients should have exhausted all standard of care therapies before entering the trial.
  • Measurable disease per RECIST1.1.
  • Male and female aged ≥ 18 years.
  • Prior to any trial-related assessments or procedures, must sign an informed consent form (ICF) indicating that he or she understands the purpose and procedures required for the trial and are willing to participate in the trial.
  • Eastern Cooperative Oncology Group performance status of 0 to 1.
  • Adequate coagulation function at screening as determined by:
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  • International normalized ratio or prothrombin time ≤ 1.5 × upper limit normal (ULN); unless on therapeutic anticoagulants with values within therapeutic window),
  • Activated partial thromboplastin time ≤ 1.5 × ULN (unless on therapeutic anticoagulants with values within therapeutic window).
  • Adequate hematologic function at screening as determined by:
  • White blood cell count (WBC) ≥ 3 × 10^9/L
  • Absolute neutrophil count ≥ 1.5 × 10^9/L (patient may not use granulocyte-colony stimulating factor or granulocyte-macrophage colony stimulating factor to achieve these WBC and absolute neutrophil count levels)
  • Platelet count ≥ 100 × 10^9/L
  • Hemoglobin ≥ 9.0 g/dL
  • Adequate hepatic function at screening as determined by:
  • Total bilirubin ≤ 1.5 mg/dL (or ≤ 2.0 mg/dL for patients with known Gilbert's syndrome or liver metastasis)
  • Aspartate aminotransferase and alanine aminotransferase ≤ 2.5 × ULN; ≤ 3 × ULN for patients with liver metastasis.
  • Albumin range ≥30 g/L
  • Adequate renal function at screening as determined by: Glomerular filtration rate (GFR) ≥ 45 mL/min/1.73 m^2 - according to the Chronic Kidney Disease Epidemiology Collaboration equation, expressed as a single equation: GFR = 141 × min(Scr/κ,1)^α × max(Scr/κ, 1)^-1.209 × 0.993^Age × 1.018 [if female] × 1.159 [if black]; Scr is serum creatinine (mg/dL), κ is 0.7 for females and 0.9 for males, α is -0.329 for females and -0.411 for males, min indicates the minimum of Scr/κ or 1, and max indicates the maximum of Scr/κ or 1. For creatinine assays using methods traceable to isotope dilution mass spectrometry assigned National Institute of Standards and Technology certified reference materials (Levey et al. 2009).
  • Able and willing to comply with scheduled visits, treatment schedule, laboratory tests, lifestyle restrictions, and other requirements of the trial.
  • Women of childbearing potential (WOCBP) must have a negative serum (beta-human chorionic gonadotropin) test/value at screening. Patients who are post-menopausal or permanently sterilized can be considered as not having reproductive potential.
  • WOCBP must agree to use highly effective contraception during the trial and for 6 months after receiving the last dose of BNT152 or BNT153. Birth control methods are considered highly effective if they have a failure rate of less than 1% per year, when used consistently and correctly.
  • WOCBP must agree not to donate eggs (ova, oocytes) for the purposes of assisted reproduction during the entire trial, until 6 months after last BNT152 or BNT153 treatment.
  • A man who is sexually active with a WOCBP and has not had a vasectomy must agree to use a barrier method of birth control, e.g., either condom with spermicidal foam/gel/film/cream/suppository or partner with occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/suppository, and all men must also agree to not donate sperm during the trial and for 6 months after receiving the last dose of BNT152 or BNT153.
  • For enrollment into the biomarker cohort only: The biomarker cohort will be conducted at selected sites only. At enrollment patients must have at least one lesion that is deemed accessible by the investigator which is different from the target lesion. Also, patients must agree to have one pre-dose biopsy (baseline) and at least one on-treatment biopsy (preferred C2D8) from the same tumor lesion.

Who cannot join

  • Prior and concomitant therapy:
  • Use of any investigational medical product or device within 28 days before administration of first dose of trial treatment.
  • Has been receiving: radiotherapy, chemotherapy, or molecularly-targeted agents or tyrosine kinase inhibitors within 2 weeks or 5 half-lives (whichever is longer) of the start of trial treatment; immunotherapy/monoclonal antibodies for systemic anticancer treatment within 3 weeks of the start of trial treatment; nitrosourea, antibody-drug conjugates, or radioactive isotopes within 6 weeks of the start of trial treatment.
  • Ongoing participation in the active treatment phase of an interventional clinical trial.
  • Receives concurrent systemic (oral or intravenous) steroid therapy >10 mg prednisone daily or its physiological equivalent for an underlying condition.
  • Has had major surgery within the 4 weeks before the first dose of trial treatment.
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  • Ongoing or active infection requiring intravenous treatment with anti-infective therapy that has been administered less than 2 weeks prior to the first dose of trial treatment.
  • Has side effects of any prior therapy or procedures for any medical condition not recovered to NCI CTCAE v.5 Grade ≤ 1. Note: peripheral neuropathy Grade ≤ 2 is allowed; alopecia of any grade is allowed.
  • Medical conditions:
  • Current evidence of new or growing brain or leptomeningeal metastases during screening. Patients with known brain metastases may be eligible if they:
  • had radiotherapy, surgery or stereotactic surgery for the brain metastases,
  • have no neurological symptoms (excluding Grade ≤ 2 neuropathy),
  • have stable brain metastasis on the computerized tomography (CT) or magnetic resonance imaging (MRI) scan within 4 weeks before signing the informed consent,
  • are not undergoing acute corticosteroid therapy or steroid taper. Notes: Patients with central nervous system symptoms should undergo a CT-scan or MRI of the brain to exclude new or progressive brain metastases. Spinal bone metastases are allowed, unless imminent fracture with cord compression is anticipated.
  • Has a history of a cerebrovascular accident or had a transient ischemic attack less than 6 months before signing the ICF.
  • Effusions (pleural, pericardial, or ascites) requiring drainage.
  • Active autoimmune disease including but not limited to inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis, scleroderma, or multiple sclerosis (except type 1 diabetes with well-regulated blood sugar).
  • Has any active immunologic disorder or after organ transplantation requiring immunosuppression with steroids or other immunosuppressive agents (e.g., azathioprine, cyclosporine A) with the exception of patients with isolated vitiligo, resolved childhood asthma or atopic dermatitis, controlled hypoadrenalism or hypopituitarism, and patients with a history of Graves' disease with stable thyroid function. Patients with controlled hyperthyroidism must be negative for thyroglobulin, thyroid peroxidase antibodies, and thyroid stimulating immunoglobulin prior to administration of trial treatment.
  • Known history of seropositivity for human immunodeficiency virus (HIV) with cluster of differentiation (CD) 4+ T-cell (CD4+) counts <350 cells/µL and with a history of acquired immunodeficiency syndrome-defining opportunistic infections.
  • Known history/positive serology for hepatitis B requiring active antiviral therapy (unless immune due to vaccination or resolved natural infection or unless passive immunization due to immunoglobulin therapy). Patients with positive serology must have hepatitis B virus viral load below the limit of quantification.
  • Active hepatitis C virus infection; patients who have completed curative antiviral treatment with hepatitis C virus viral load below the limit of quantification are allowed.
  • Notes: Country-specific criterion for Czech Republic: To confirm that a patient would be eligible, an active infection with HIV/Hepatitis B or C should be ruled out by serum blood test at screening.
  • Known hypersensitivity to a component of any trial treatment.
  • Another primary malignancy that has not been in remission for at least 2 years, with the exception of those with a negligible risk of metastasis or death (including but not limited to adequately treated carcinoma in situ of the cervix, basal or squamous cell skin cancer, localized prostate cancer, or ductal carcinoma in situ). In case of uncertainties, the medical monitor should be consulted.
  • Other comorbidities:
  • Abnormal electrocardiograms that are clinically significant, such as Fridericia-corrected QT prolongation >480 ms.
  • In the opinion of the treating investigator, has any concurrent conditions that could pose an undue medical hazard or interfere with the interpretation of the trial results; these conditions include, but are not limited to:
  • Ongoing or active infection requiring antibiotic/antiviral/antifungal therapy.
  • Concurrent congestive heart failure (New York Heart Association Functional Classification Class III or IV).
  • Concurrent unstable angina.
  • Known medical history of cardiac arrhythmia (including asymptomatic atrial fibrillation).
  • Acute coronary syndrome within the previous 6 months.
  • Symptomatic pulmonary embolism within the previous 3 months.
  • Significant pulmonary disease (shortness of breath at rest or on mild exertion) for example due concurrent severe obstructive pulmonary disease.
  • Cognitive, psychological or psychosocial impediment that would impair the ability of the patient to receive therapy according to the protocol or adversely affect the ability of the patient to comply with the informed consent process, protocol, or protocol-required visits and procedures.
  • Is pregnant or breastfeeding.
  • Patients unable to consent.
  • Use of any live vaccines from 30 days prior to administration of first dose of trial treatment, during the trial, and 90 days after administration of last dose of trial treatment.

Trial locations and contacts

7 sites in 2 countries.

7 sites in 2 countries

United States6 sites

  • Robert H. Lurie Comprehensive Cancer Center, Northwestern University

    Chicago, Illinois, 60611

  • Duke Cancer Center

    Durham, North Carolina, 27710

  • MD Anderson Cancer Center

    Houston, Texas, 77030

  • Sarah Cannon Research Institute at Tennessee Oncology

    Nashville, Tennessee, 37203

  • Yale Cancer Center

    New Haven, Connecticut, 06520

  • NEXT Oncology

    San Antonio, Texas, 78229

Other trials in United States

Czechia1 site

  • Masaryk Memorial Cancer Institute

    Brno, 65653

Other trials in Czechia

About this study

Official title: Phase I, First-in-human, Open-label, Dose Escalation Trial to Evaluate Safety, Pharmacokinetics, Pharmacodynamics, and Anti-tumor Activity of BNT152+153 in Patients With Solid Tumors

This is an open-label, multisite Phase I dose escalation, safety, pharmacokinetics (PK) and pharmacodynamics (PD) trial of BNT152+153 in various solid tumor indications.

The clinical trial will enroll patients with various solid tumors that are metastatic or unresectable for whom there is no available standard therapy likely to confer clinical benefit, or patients who are not candidates for such available therapy.

Read more

The trial consists of Part 1 and Part 2 with adaptive design elements:

  • Part 1 consists of Groups A and B.
  • Group A is a BNT153 monotherapy dose escalation in patients with advanced solid malignancies until the maximal tolerated dose (MTD) is defined. If MTD is not reached, maximum administered dose (MAD) may be used for further development (or another dose as determined by the safety review committee [SRC]).
  • Group B is a BNT152 monotherapy dose escalation in patients with advanced solid malignancies until the MTD or optimal biological dose (OBD; the lowest safe dose associated with optimal biological activity) is defined, whichever occurs earlier.
  • Group A will be activated first while the time point for Group B activation is at sponsor's decision.
  • Part 2 will start after the MTD or MAD or another dose as determined by the SRC have been established for BNT153 and MTD or OBD for BNT152 in Part 1. Part 2 (Part 2A, 2B and 2C) is a dose escalation of BNT152+153 in patients with advanced solid malignancies until the recommended Phase II dose (RP2D) is defined.
  • Part 2 may implement a biomarker cohort if a clinical benefit is observed at one or more doses of BNT152+153 that show a clear PD effect in the peripheral blood. The Biomarker Cohort will recruit patients at selected sites.
Read the detailed description

The Part 2 starts with Part 2A. Enrollment of Part 2B begins after dose level 1 in Part 2A is deemed safe by the SRC. The dose escalation in Part 2A continues as described in the protocol. The dose escalation in Part 2B continues as described in the protocol until RP2D is determined. To further investigate the effect of BNT152+153, Part 2C may be introduced upon review of the emerging data.

Conditions
Solid Tumor
Being tested
BNT152, BNT153
Keywords
BioNTech SE, Solid Tumors, Metastatic, Unresectable, Advanced solid malignancies
Medical subject headings
Neoplasm Metastasis

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • BNT152Drug

    intravenous

  • BNT153Drug

    intravenous

Study groups in NCT04710043
Study groupRoleWhat they receive
Part 1 group A BNT153ExperimentalMonotherapy dose escalation.
Receives: Drug: BNT153
Part 1 group B BNT152ExperimentalMonotherapy dose escalation.
Receives: Drug: BNT152
Part 2A - BNT152+153ExperimentalEscalating dose levels up to RP2D
Receives: Drug: BNT152; Drug: BNT153
Part 2B - BNT152+153ExperimentalEscalating dose levels up to RP2D
Receives: Drug: BNT152; Drug: BNT153
Part 2C - BNT152+153ExperimentalEscalating dose levels up to RP2D
Receives: Drug: BNT152; Drug: BNT153
Part 2 - BNT152+153 - biomarker cohortExperimentalNot described
Receives: Drug: BNT152; Drug: BNT153

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Occurrence of treatment-emergent adverse events (TEAEs) including Grade ≥ 3, serious, fatal TEAE by causal relationship to trial treatment

    TEAEs will be graded according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) v.5.0.

    Measured: up to 24 months

  2. Occurrence of dose reduction and discontinuation of investigational medicinal product within a patient due to TEAE

    Measured: up to 24 months

  3. Occurrence of dose limiting toxicities (DLTs) during the DLT evaluation period - BNT152

    Measured: 21 days

  4. Occurrence of DLTs during the DLT evaluation period - BNT153

    Measured: 21 days

Secondary outcomes (3)

  1. Objective response rate (ORR)

    ORR is defined as the proportion of patients in whom a complete response (CR) or partial response (PR) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) is observed as best overall response.

    Measured: up to 24 months

  2. Disease control rate (DCR)

    DCR is defined as the proportion of patients in whom a CR or PR or stable disease (SD) (per RECIST 1.1, SD assessed at least 6 weeks after first dose) is observed as best overall response.

    Measured: up to 24 months

  3. Duration of response (DOR)

    DOR is defined as the time from first overall response (CR or PR per RECIST 1.1) to first occurrence of objective tumor progression (progressive disease (PD) per RECIST 1.1) or death from any cause, whichever occurs first.

    Measured: up to 24 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted14 Jan 2021
  2. Study start8 Jun 2021
  3. Primary completion10 Sep 2025
  4. Study completion10 Sep 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 1
Primary purpose
Treatment
Allocation
Non-randomised
Intervention model
Sequential
Masking
None (open label)
Enrolment
86 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT04710043
Sponsor's protocol ID
BNT152-01C
Other IDs
2021-005599-20, 2023-509508-13-00, 2023
Status last verified
Sep 2025
First submitted
12 Jan 2021
Last updated
25 Sep 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A Phase 1 study testing BNT152 and BNT153 in people with Solid Tumor, run by BioNTech SE at 7 sites in 2 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 24 inclusion and 38 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 25 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 7 sites in United States, Czechia. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Occurrence of treatment-emergent adverse events (TEAEs) including Grade ≥ 3, serious, fatal TEAE by causal relationship to trial treatment (time frame: up to 24 months). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT04710043.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2025.

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