Complex Regional Pain SyndromesImagNimesNCT04703348
The Complex Regional Pain Syndrome (CRPS) is a Chronic Pain Condition. This is a Preliminary Study to Explore and Test Clinical Hypothesis. They Suppose That CRPS Patients Have Impairment in Their Mental or Motor Imagery Abilities.
A study testing Motor imagery Questionnaire - Revised Second (MIQ-RS) in people with Complex Regional Pain Syndromes and Musculoskeletal Pain Disorder, run by Centre Hospitalier Universitaire de Nīmes at 1 site in France.
Trial summary
Medical functional imagery seems to demonstrate that patients suffering from complex regional pain syndrome (CRPS) have cortical modifications that alter their motor (or mental) imagery capacities. Nowadays, the use of motor imagery exercises are used in conventional rehabilitation treatments. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Complex Regional Pain Syndromes, Musculoskeletal Pain Disorder, Healthy
- What is being tested?
- Motor imagery Questionnaire - Revised Second (MIQ-RS)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 129 participants
- Where
- 1 siteFrance
- Study dates
- 12 Jan 2021to 30 Oct 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Patient with French healthcare affiliation
- Adult patient (> 18 years old)
- Patient with bachelor degree minimum
- Patient practicing less than 150 minutes of moderate to intense physical activity per week
- Specific Inclusion Criteria for CRPS group :
- Patient followed in the Evaluation and Treatment pain center (University Hospital of Nimes)
Show all 28Show fewer
- Patient with secondary CRPS due to a traumatism or a surgery
- Specific Inclusion Criteria for Musculoskeletal group :
- Patient with musculoskelettal disorder on a limb (upper or lower)
- Patient followed in the University Hospital of Nimes
- Non inclusion Criteria :
- Patient who participates in another category 1 research
- Patient in a exclusion period in another study
- Patient under legal protection, under guardianship or under curatorship
- Patient for whom it is impossible to give clear information.
- Pregnant, parturient or breastfeeding patient.
- Patient with amputation on one of his limb
- Patient with visual cecity
- Patient who has already practiced mental imagery
- Patient with neurological impairment
- Patient with chronic low back pain and fibromyalgia
- Specific non inclusion criteria for Musculoskeletal group and healthy group :
- -Patient with CRPS
- Specific non inclusion Criteria for CRPS group :
- Secondary CRPS to CVA (cerebrovascular accident)
- Patient receiving lymph node block treatment between the inclusion visit and the follow-up visit
- Specific non inclusion Criteria for Musculoskeletal Disorder group :
- Patient with secondary musculoskeletal disorder to a CVA
Who cannot join
- Questionnaire MIQ-RS not completed or non respect with the research protocol
- pathology discovered incompatible with the study criteria
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Pilot Study on the Assessment of Motor Imaging Skills in Patients With Complex Regional Pain Syndrome (CRPS)
Medical functional imagery seems to demonstrate that patients suffering from complex regional pain syndrome (CRPS) have cortical modifications that alter their motor (or mental) imagery capacities. Nowadays, the use of motor imagery exercises are used in conventional rehabilitation treatments. But, in clinical practice, no study has verified if patients with CRPS desmonstrate problems in their motor imagery capacities. The MIQ-RS (Motor Imagery Questionnaire - Revised Second) is a valid, reliable and translated into French questionnaire to measure patients' capacities to do mental imagery. In this study, we compare 3 groups of 50 patients : healthy patients, patients with CRPS and patients with musculoskeletal disorder without CRPS. Every patient will take the MIQ-RS for the right and left body side. We hypothesis that patients with CRPS have more deficit than the 2 others to realise motor imagery.
- Being tested
- Motor imagery Questionnaire - Revised Second (MIQ-RS)
- Keywords
- complex regional pain syndromes, motor imagery, mental imagery, MIQ-RS, Pilot study, comparison groups, CRPS
- Medical subject headings
- Complex Regional Pain Syndromes, Collagen Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Motor imagery Questionnaire - Revised Second (MIQ-RS)Diagnostic test
Patients fulfill a questionnaire measuring individuals capacities to realize mental imagery. For more facilities and less risk of bias, the MIQ-RS was written on an online version with questions recorded in audio format. No official cut-off exists but studies seem to prove that people with :
- a score less than 48/98 are unable to do motor imagery
- a score between 49 and 73/98 have disturbed motor imagery capacities
- a score more than 74/98 have normal motor imagery capacities.
| Study group | Role | What they receive |
|---|---|---|
| Healthy patients | Other | Healthy patients take the MIQ-RS during about 40 minutes : about 20 minutes for the assessment of the right side and about 20 minutes for the left side Receives: Diagnostic Test: Motor imagery Questionnaire - Revised Second (MIQ-RS) |
| Complex regional pain syndrome patients | Other | Complex regional pain syndrome patients take the MIQ-RS during about 40 minutes : about 20 minutes for the assessment of the right side and about 20 minutes for the left side Receives: Diagnostic Test: Motor imagery Questionnaire - Revised Second (MIQ-RS) |
| Musculoskelettal disorders patients | Other | Musculoskelettal disorders patients take the MIQ-RS during about 40 minutes : about 20 minutes for the assessment of the right side and about 20 minutes for the left side Receives: Diagnostic Test: Motor imagery Questionnaire - Revised Second (MIQ-RS) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Motor imagery capacities on the affected side for CRPS group and musculoskelettal disorder group.
Taking the MIQ-RS for 1 side, during about 20 minutes The questionnaire includes 14 questions : 7 for kinesthesic motor imagery and 7 for visual motor imagery For less bias, the questionnaire was recorded in audio for each of the 14 questions on an online assessment.
No official cut-off exists but studies seem to prove that people with :
- a score less than 48/98 are unable to do motor imagery
- a score between 49 and 73/98 have disturbed motor imagery capacities
- a score more than 74/98 have normal motor imagery capacities.
Measured: Day 1
Secondary outcomes (1)
Motor imagery capacities between affected side and unaffected side
Taking the MIQ-RS for 1 side, during about 20 minutes The questionnaire includes 14 questions : 7 for kinesthesic motor imagery and 7 for visual motor imagery For less bias, the questionnaire was recorded in audio for each of the 14 questions on an online assessment.
No official cut-off exists but studies seem to prove that people with :
- a score less than 48/98 are unable to do motor imagery
- a score between 49 and 73/98 have disturbed motor imagery capacities
- a score more than 74/98 have normal motor imagery capacities.
Measured: Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jan 2021
- Study start12 Jan 2021
- Primary completion30 Oct 2022
- Study completion30 Oct 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Complex Regional Pain SyndromesStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire de NīmesThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Screening
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- 3 groups with different healthcare conditions are compared in motor imagery capacities
- Masking
- None (open label)
- Enrolment
- 129 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire de Nīmes
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04703348
- Sponsor's protocol ID
- LOCAL/2020/MO-01
- Other IDs
- 2020-A02281-38
- Acronym
- ImagNimes
- Status last verified
- Nov 2022
- First submitted
- 7 Jan 2021
- Last updated
- 4 Dec 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Cohen-Aknine G, Mottet D, Homs AF, Mura T, Jedryka F, Dupeyron AF. Explicit Motor Imaging Abilities Are Similar in Complex Regional Pain Syndrome, Chronic Limb Pain and Healthy Individuals: A Cross-Sectional Study. J Pain Res. 2025 Apr 11;18:1949-1961. doi: 10.2147/JPR.S494546. eCollection 2025.
PubMed 40236719
Study at a glance
From the registry record, last updated by the sponsor on 4 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Pilot Study on the Assessment of Motor Imaging Skills in Patients With Complex Regional Pain Syndrome (CRPS)
- ClinicalTrials.gov ID
- NCT04703348
- Acronym / sponsor ID
- ImagNimes / LOCAL/2020/MO-01
- Keywords
- complex regional pain syndromes, motor imagery, mental imagery, MIQ-RS, Pilot study, comparison groups, CRPS
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 129 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire de NīmesUniversity, hospital or other
- Study start
- 12 Jan 2021 (actual)
- Primary completion
- 30 Oct 2022 (actual)
- Study completion
- 30 Oct 2022 (actual)
- First posted
- 11 Jan 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Medical functional imagery seems to demonstrate that patients suffering from complex regional pain syndrome (CRPS) have cortical modifications that alter their motor (or mental) imagery capacities. Nowadays, the use of motor imagery exercises are used in conventional rehabilitation treatments. But, in clinical practice, no study has verified if patients with CRPS desmonstrate problems in their motor imagery capacities. The MIQ-RS (Motor Imagery Questionnaire - Revised Second) is a valid, reliable and translated into French questionnaire to measure patients' capacities to do mental imagery. In this study, we compare 3 groups of 50 patients : healthy patients, patients with CRPS and patients with musculoskeletal disorder without CRPS. Every patient will take the MIQ-RS for the right and left body side. We hypothesis that patients with CRPS have more deficit than the 2 others to realise motor imagery.
Study design
- Primary purpose
- Screening
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- 3 groups with different healthcare conditions are compared in motor imagery capacities
| Arm | Type | Receives |
|---|---|---|
| Healthy patients | Other | Diagnostic Test: Motor imagery Questionnaire - Revised Second (MIQ-RS)Healthy patients take the MIQ-RS during about 40 minutes : about 20 minutes for the assessment of the right side and about 20 minutes for the left side |
| Complex regional pain syndrome patients | Other | Diagnostic Test: Motor imagery Questionnaire - Revised Second (MIQ-RS)Complex regional pain syndrome patients take the MIQ-RS during about 40 minutes : about 20 minutes for the assessment of the right side and about 20 minutes for the left side |
| Musculoskelettal disorders patients | Other | Diagnostic Test: Motor imagery Questionnaire - Revised Second (MIQ-RS)Musculoskelettal disorders patients take the MIQ-RS during about 40 minutes : about 20 minutes for the assessment of the right side and about 20 minutes for the left side |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (28 listed)
- Patient with French healthcare affiliation
- Adult patient (> 18 years old)
- Patient with bachelor degree minimum
- Patient practicing less than 150 minutes of moderate to intense physical activity per week
- Patient followed in the Evaluation and Treatment pain center (University Hospital of Nimes)
Key exclusion criteria (2 listed)
- Questionnaire MIQ-RS not completed or non respect with the research protocol
- pathology discovered incompatible with the study criteria
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Motor imagery Questionnaire - Revised Second (MIQ-RS)Patients fulfill a questionnaire measuring individuals capacities to realize mental imagery. For more facilities and less risk of bias, the MIQ-RS was written on an online version with questions recorded in audio format. No official cut-off exists but studies seem to prove that people with : * a score less than 48/98 are unable to do motor imagery * a score between 49 and 73/98 have disturbed motor imagery capacities * a score more than 74/98 have normal motor imagery capacities. | Diagnostic test | Complex regional pain syndrome patients, Healthy patients, Musculoskelettal disorders patients |
Primary outcome
Motor imagery capacities on the affected side for CRPS group and musculoskelettal disorder group.
Time frame: Day 1
Taking the MIQ-RS for 1 side, during about 20 minutes The questionnaire includes 14 questions : 7 for kinesthesic motor imagery and 7 for visual motor imagery For less bias, the questionnaire was recorded in audio for each of the 14 questions on an online assessment. No official cut-off exists but studies seem to prove that people with : * a score less than 48/98 are unable to do motor imagery * a score between 49 and 73/98 have disturbed motor imagery capacities * a score more than 74/98 have normal motor imagery capacities.
1 secondary outcome
Motor imagery capacities between affected side and unaffected side
Time frame: Day 1
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Dec 2025.
- Results publication: PubMed 40236719Cohen-Aknine G, Mottet D, Homs AF, Mura T, Jedryka F, Dupeyron AF. Explicit Motor Imaging Abilities Are Similar in Complex Regional Pain Syndrome, Chronic Limb Pain and Healthy Individuals: A Cross-Sectional Study. J Pain Res. 2025 Apr 11;18:1949-1961. doi: 10.2147/JPR.S494546. eCollection 2025.
- Related InfoLink provided by the sponsor.
- Related InfoLink provided by the sponsor.
Related trials for Complex Regional Pain Syndromes
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Recruiting
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CRPS (Complex Regional Pain Syndromes)
RecruitingPhase 3
Phase 3, Open-Label Extension Study of AMBTX-01 (Neridronate) for Complex Regional Pain Syndrome Type 1
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Active, not recruiting
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Motor imagery Questionnaire - Revised Second (MIQ-RS) in people with Complex Regional Pain Syndromes and Musculoskeletal Pain Disorder, run by Centre Hospitalier Universitaire de Nīmes at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 28 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Motor imagery capacities on the affected side for CRPS group and musculoskelettal disorder group. (time frame: Day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04703348, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Dec 2025.