Elite CyclistsIDperformNCT04637178
Predicting the Efficacy of Resistance Exercise Training for Improving Endurance Performance
A study testing Resistance training and Endurance training (habitual) in people with Elite Cyclists, run by Inland Norway University of Applied Sciences at 1 site in Norway.
Trial summary
The overall objective of the study is to identify molecular determinants of the efficacy of resistance training for improving endruance performance in elite cyclists Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Elite Cyclists
- What is being tested?
- Resistance training and Endurance training (habitual)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 25 participants
- Where
- 1 siteNorway
- Study dates
- 16 Nov 2020to 26 Feb 2021
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- VO2max > 65 ml/kg/min (male participants)
- VO2max > 50 ml/kg/min (female participants)
- >7 hours of endurance training per week for the 6 months leading up to the study
Who cannot join
- having conducted regular resistance training for the last 6 months leading up to the study
Trial locations and contacts
1 site in 1 country.
Norway1 site
Inland Norway University of Applied Sciences
Lillehammer, Inland Norway, 2613
About this study
Official title: Identifying Molecular Determinants for the Efficacy of Resistance Training for Improving Endurance Performance in Elite Cyclists
The overall objective of the study is to identify molecular determinants of the efficacy of resistance training for improving endruance performance in elite cyclists
Read the detailed description
For elite endurance athletes, the addition of resistance training to habitual endurance training routines generally leads to improved endurance performance. However, this is not always the case, with several individuals failing to respond in the expected manner. This inter-individual variation is likely associated with inherent cellular and molecular charateristics of skeletal muscle. Indeed, responses to resistance training seem to be associated with muscle biological characteristics such as muscle fiber composition and ribosomal content (during the early phase of resistance training).
The study will investigate the association between muscle fibre composition (type I vs type II muscle fiber proportions) / ribosomal content in m. vastus lateralis and the effects of 10 weeks of resistance training on endurance performance in 52 elite cyclists. Half the participants will perform resistance training in addition to their habitual endurance training routines, the other half will perform endurance training-only. Muscle biopsies will be sampled from m. vastus lateralis before and after the first two weeks of the intervention. For muscle fiber composition, the hypothesis is that larger proportions of type II fibers will be associated with more pronounced benefits of resistance training. For ribosomal content, the hypothesis is that higher rRNA content at baseline and larger increases in rRNA content during the initial part of the intervention will be associated with more pronounced benefits of resistance training. No changes are expected in the non-resistance training control group.
- Conditions
- Elite Cyclists
- Being tested
- Resistance training, Endurance training (habitual)
- Keywords
- Cycling, Endurance performance, Skeletal muscle biology, Individualization, Muscle fiber type proportions, Ribosomal RNA
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resistance trainingBehavioural
Also called Heavy-load strength training
Resistance training sessions twice a week for ten weeks
Endurance training (habitual)Behavioural
Endurance training for ten weeks (habitual routines)
| Study group | Role | What they receive |
|---|---|---|
| Resistance training added to endurance training | Experimental | Participants (elite cyclists) will conduct heavy-load resistance training twice a week in addition to their habitual endurance training for ten weeks Receives: Behavioral: Resistance training; Behavioral: Endurance training (habitual) |
| Endurance training | Other | Participants (elite cyclists) will conduct habitual endurance training-only for ten weeks Receives: Behavioral: Endurance training (habitual) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Performance during a 40-minute all-out cycling test
Mean power output measured during a 40-minute all-out cycling test
Measured: Changes from before the intervention to immediately after the intervention
Performance during a 15-minute all-out cycling test
Mean power output measured during a 15-minute all-out cycling test
Measured: Changes from before the intervention to immediately after the intervention
Secondary outcomes (25)
Total RNA in muscle tissue (before intervention)
Total RNA content in m. vastus lateralis (ug per mg tissue)
Measured: Before the intervention
Total RNA in muscle tissue (changes after two weeks)
Total RNA content in m. vastus lateralis (ug per mg tissue)
Measured: Changes from before the intervention to immediately after the initial two weeks of resistance training
Muscle fiber proportions (before intervention)
Muscle fiber proportions in m. vastus lateralis measured using immunohistochemistry
Measured: Before the intervention
Muscle fiber proportions (changes after two weeks)
Muscle fiber proportions in m. vastus lateralis measured using immunohistochemistry
Measured: Changes from before the intervention to immediately after the initial two weeks of resistance training
Muscle fiber cross-sectional area (before intervention)
Cross-sectional area of muscle fibres in m. vastus lateralis measured using immunohistochemistry
Measured: Before the intervention
Muscle fiber cross-sectional area (changes after two weeks)
Cross-sectional area of muscle fibres in m. vastus lateralis measured using immunohistochemistry
Measured: Changes from before the intervention to immediately after the initial two weeks of resistance training
Myonuclear number (before intervention)
Myonuclei per muscle fiber in m. vastus lateralis measured using immunohistochemistry
Measured: Before the intervention
Myonuclear number (changes after two weeks)
Myonuclei per muscle fiber in m. vastus lateralis measured using immunohistochemistry
Measured: Changes from before the intervention to immediately after the initial two weeks of resistance training
rRNA expression (before intervention)
rRNA abundances in m. vastus lateralis measured using qPCR
Measured: Before the intervention
rRNA expression (changes after two weeks)
rRNA abundances in m. vastus lateralis measured using qPCR
Measured: Changes from before the intervention to immediately after the initial two weeks of resistance training
mRNA expression (before intervention)
mRNA abundances in m. vastus lateralis measured using qPCR
Measured: Before the intervention
mRNA expression (changes after two weeks)
mRNA abundances in m. vastus lateralis measured using qPCR
Measured: Changes from before the intervention to immediately after the initial two weeks of resistance training
Maximal concentric force production
Maximal concentric force production measured using a seated leg press test
Measured: Changes from before the intervention to immediately after the intervention
Sprint performance
Mean power output measured during a 10-second all-out cycling sprint
Measured: Changes from before the intervention to immediately after the intervention
Maximal oxygen consumption
Maximal oxygen consumption measured during an incremental cycling exercise test to exhaustion
Measured: Changes from before the intervention to immediately after the intervention
Maximal aerobic power output
Maximal aerobic power output measured as mean power output during the last minute of an incremental cycling exercise test to exhaustion
Measured: Changes from before the intervention to immediately after the intervention
Power output at lactate threshold
Power output at 4 mmol blood lactate concentration measured during an incremental cycling exercise test (with 5 minute steps)
Measured: Changes from before the intervention to immediately after the intervention
Gross efficiency
Contribution of total energy turnover to power output in the fresh and fatigued state
Measured: Changes from before the intervention to immediately after the intervention
Fractional utilization of VO2max (incremental test)
Fractional utilization of VO2max measured at 4 mmol blood lactate concentrations measured during an incremental cycling exercise test (with 5 minute steps)
Measured: Changes from before the intervention to immediately after the intervention
Fractional utilization of VO2max (15-minute performance test)
Fractional utilization of VO2max measured during a 15-minute performance test
Measured: Changes from before the intervention to immediately after the intervention
Hemoglobin mass
Hemoglobin mass measured using CO rebreathing (g)
Measured: Changes from before the intervention to immediately after the intervention
Blood volume
Blood volume measured using CO rebreathing
Measured: Changes from before the intervention to immediately after the intervention
Plasma volume
Plasma volume measured using CO rebreathing
Measured: Changes from before the intervention to immediately after the intervention
Red blood cell volume
Red blood cell volume measured using CO rebreathing
Measured: Changes from before the intervention to immediately after the intervention
Hematocrit
Hematocrit measured using centrifugation
Measured: Changes from before the intervention to immediately after the intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Nov 2020
- Study start16 Nov 2020
- Primary completion26 Feb 2021
- Study completion26 Feb 2021
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Elite CyclistsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 25 participants (actual)
Sponsor and investigators
- Lead sponsor
- Inland Norway University of Applied Sciences
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Anne S Lofthus, Study chair, Research Administrator
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04637178
- Sponsor's protocol ID
- Trainome 2020#025-2
- Acronym
- IDperform
- Status last verified
- Nov 2020
- First submitted
- 12 Nov 2020
- Last updated
- 1 Mar 2021
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 Mar 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Identifying Molecular Determinants for the Efficacy of Resistance Training for Improving Endurance Performance in Elite Cyclists
- ClinicalTrials.gov ID
- NCT04637178
- Acronym / sponsor ID
- IDperform / Trainome 2020#025-2
- Conditions
- Elite Cyclists
- Keywords
- Cycling, Endurance performance, Skeletal muscle biology, Individualization, Muscle fiber type proportions, Ribosomal RNA
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 25 participants (actual)
- Lead sponsor
- Inland Norway University of Applied SciencesUniversity, hospital or other
- Study start
- 16 Nov 2020 (actual)
- Primary completion
- 26 Feb 2021 (actual)
- Study completion
- 26 Feb 2021 (actual)
- First posted
- 19 Nov 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The overall objective of the study is to identify molecular determinants of the efficacy of resistance training for improving endruance performance in elite cyclists
Detailed description
For elite endurance athletes, the addition of resistance training to habitual endurance training routines generally leads to improved endurance performance. However, this is not always the case, with several individuals failing to respond in the expected manner. This inter-individual variation is likely associated with inherent cellular and molecular charateristics of skeletal muscle. Indeed, responses to resistance training seem to be associated with muscle biological characteristics such as muscle fiber composition and ribosomal content (during the early phase of resistance training).
The study will investigate the association between muscle fibre composition (type I vs type II muscle fiber proportions) / ribosomal content in m. vastus lateralis and the effects of 10 weeks of resistance training on endurance performance in 52 elite cyclists. Half the participants will perform resistance training in addition to their habitual endurance training routines, the other half will perform endurance training-only. Muscle biopsies will be sampled from m. vastus lateralis before and after the first two weeks of the intervention. For muscle fiber composition, the hypothesis is that larger proportions of type II fibers will be associated with more pronounced benefits of resistance training. For ribosomal content, the hypothesis is that higher rRNA content at baseline and larger increases in rRNA content during the initial part of the intervention will be associated with more pronounced benefits of resistance training. No changes are expected in the non-resistance training control group.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Resistance training added to endurance training | Experimental | Behavioral: Resistance training, Behavioral: Endurance training (habitual)Participants (elite cyclists) will conduct heavy-load resistance training twice a week in addition to their habitual endurance training for ten weeks |
| Endurance training | Other | Behavioral: Endurance training (habitual)Participants (elite cyclists) will conduct habitual endurance training-only for ten weeks |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- VO2max > 65 ml/kg/min (male participants)
- VO2max > 50 ml/kg/min (female participants)
- >7 hours of endurance training per week for the 6 months leading up to the study
Key exclusion criteria (1 listed)
- having conducted regular resistance training for the last 6 months leading up to the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resistance trainingAlso: Heavy-load strength trainingResistance training sessions twice a week for ten weeks | Behavioural | Resistance training added to endurance training |
| Endurance training (habitual)Endurance training for ten weeks (habitual routines) | Behavioural | Endurance training, Resistance training added to endurance training |
Primary outcome
Performance during a 40-minute all-out cycling test
Time frame: Changes from before the intervention to immediately after the intervention
Mean power output measured during a 40-minute all-out cycling test
Performance during a 15-minute all-out cycling test
Time frame: Changes from before the intervention to immediately after the intervention
Mean power output measured during a 15-minute all-out cycling test
25 secondary outcomes
Total RNA in muscle tissue (before intervention)
Time frame: Before the intervention
Total RNA in muscle tissue (changes after two weeks)
Time frame: Changes from before the intervention to immediately after the initial two weeks of resistance training
Muscle fiber proportions (before intervention)
Time frame: Before the intervention
Muscle fiber proportions (changes after two weeks)
Time frame: Changes from before the intervention to immediately after the initial two weeks of resistance training
Muscle fiber cross-sectional area (before intervention)
Time frame: Before the intervention
Muscle fiber cross-sectional area (changes after two weeks)
Time frame: Changes from before the intervention to immediately after the initial two weeks of resistance training
Myonuclear number (before intervention)
Time frame: Before the intervention
Myonuclear number (changes after two weeks)
Time frame: Changes from before the intervention to immediately after the initial two weeks of resistance training
rRNA expression (before intervention)
Time frame: Before the intervention
rRNA expression (changes after two weeks)
Time frame: Changes from before the intervention to immediately after the initial two weeks of resistance training
mRNA expression (before intervention)
Time frame: Before the intervention
mRNA expression (changes after two weeks)
Time frame: Changes from before the intervention to immediately after the initial two weeks of resistance training
Maximal concentric force production
Time frame: Changes from before the intervention to immediately after the intervention
Sprint performance
Time frame: Changes from before the intervention to immediately after the intervention
Maximal oxygen consumption
Time frame: Changes from before the intervention to immediately after the intervention
Maximal aerobic power output
Time frame: Changes from before the intervention to immediately after the intervention
Power output at lactate threshold
Time frame: Changes from before the intervention to immediately after the intervention
Gross efficiency
Time frame: Changes from before the intervention to immediately after the intervention
Fractional utilization of VO2max (incremental test)
Time frame: Changes from before the intervention to immediately after the intervention
Fractional utilization of VO2max (15-minute performance test)
Time frame: Changes from before the intervention to immediately after the intervention
Hemoglobin mass
Time frame: Changes from before the intervention to immediately after the intervention
Blood volume
Time frame: Changes from before the intervention to immediately after the intervention
Plasma volume
Time frame: Changes from before the intervention to immediately after the intervention
Red blood cell volume
Time frame: Changes from before the intervention to immediately after the intervention
Hematocrit
Time frame: Changes from before the intervention to immediately after the intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Mar 2021.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Anne S Lofthus study chair
Research Administrator
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resistance training and Endurance training (habitual) in people with Elite Cyclists, run by Inland Norway University of Applied Sciences at 1 site in Norway.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 Mar 2021. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Norway. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Performance during a 40-minute all-out cycling test (time frame: Changes from before the intervention to immediately after the intervention). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Mar 2021.