AzTrials
AzTrials

Rheumatoid Arthritis (RA)UPHOLDNCT04497597

A Study of Oral Upadacitinib Tablets to Assess Treatment Patterns, Achievement of Treatment Targets and Maintenance of Response in Adult Participants With Moderate to Severe Rheumatoid Arthritis

An observational study of Rheumatoid Arthritis (RA), run by AbbVie at 263 sites in 19 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. Despite the range of treatment options for RA steadily increasing, many patients remain sub-optimally managed, with sustained clinical remission rarely achieved. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Rheumatoid Arthritis (RA)
How many people
1,532 participants
Where
263 sitesin 19 countries
Study dates
16 Oct 2020to 15 May 2024
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: Adults receiving Upadacitinib according to the product prescribing information, for moderate to severe active Rheumatoid Arthritis (RA).

Who may be able to join

  • Confirmed diagnosis of moderate to severe active Rheumatoid Arthritis (RA).
  • Physician decision on patient treatment with upadacitinib must have been reached prior to and independently of recruitment in the study.
  • Upadacitinib prescribed in accordance to the applicable approved label and local regulatory and reimbursement policies.
  • French Participants Only: Taking oral glucocorticoids ≥5 mg/day of prednisone or equivalent for at least 3 months prior to study start.

Who cannot join

  • Prior treatment with Upadacitinib.

Trial locations and contacts

263 sites in 19 countries.

263 sites in 19 countries

France73 sites

  • CH du Pays d'AIX /ID# 229561

    Aix-en-Provence, 13616

  • Cabinet medical /ID# 225366

    Aix-les-Bains, Savoie, 73100

  • Cabinet medical /ID# 224850

    Albi, Tarn, 81000

  • CHU Amiens-Picardie Site Sud /ID# 222444

    Amiens, Somme, 80054

  • Centre Hospitalier d'Angouleme /ID# 226064

    Angoulême, Charente, 16959

  • Cabinet Novel d'Annecy /ID# 232310

    Annecy, 74000

  • Centre Hospitalier d'Arras /ID# 223172

    Arras, 62022

  • CHU de Besancon - Jean Minjoz /ID# 222463

    Besançon, Doubs, 25030

  • Hopital Avicenne - APHP /ID# 224248

    Bobigny, Île-de-France Region, 93000

  • CHU Bordeaux - Hopital Pellegrin /ID# 224837

    Bordeaux, Gironde, 33076

  • Centre Hospitalier de Boulogne Sur Mer /ID# 222991

    Boulogne-sur-Mer, 62200

  • Hopital de la Cavale Blanche /ID# 222462

    Brest, Finistere, 29200

  • cabinet liberal- Dr CORNILLE /ID# 227869

    Caen, Calvados, 14000

  • Centre Hospitalier Jean Rougie /ID# 224242

    Cahors, 46005

  • Infirmerie Protestante /ID# 222438

    Caluire-et-Cuire, Rhone, 69300

  • CH Cannes - les Broussailles /ID# 226160

    Cannes, Alpes-Maritimes, 06414

  • CHRU Tours - Hopital Trousseau /ID# 222445

    Chambray-lès-Tours, 37170

  • Centre Hospitalier de CHOLET /ID# 222455

    Cholet, 49300

  • Hia Percy /Id# 225642

    Clamart, 92190

  • CHU Clermont Ferrand - Hopital Gabriel Montpied /ID# 223801

    Clermont-Ferrand, 63000

  • Cabinet liberal - Compiegne - Dr Banse /ID# 227099

    Compiègne, Oise, 60200

  • C. H. Sud Francilien /ID# 222446

    Corbeil-Essonnes, 91106

  • CHU Dijon /ID# 223799

    Dijon, Cote-d Or, 21000

  • Cabinet medical /ID# 225142

    Haguenau, 67500

  • CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 229086

    La Roche-sur-Yon, Vendee, 85000

  • CH La Rochelle - Hopital Saint Louis /ID# 224240

    La Rochelle, 17019

  • CHU Grenoble - Hopital Michallon /ID# 223211

    La Tronche, Isere, 38700

  • Centre Hospitalier de Laon /ID# 224857

    Laon, Aisne, 02001

  • CH Emile Roux Le Puy en Velay /ID# 223688

    Le Puy-en-Velay, 43000

  • Cabinet médical /ID# 225000

    Les Abrets En Dauphine, Isere, 38490

  • CHU Lille - Hôpital Roger Salengro /ID# 223170

    Lille, 59037

  • CHU Limoges - Dupuytren 1 /ID# 222457

    Limoges, Franche-Comte, 87042

  • Clinique de la Sauvegarde /ID# 223424

    Lyon, 69009

  • Hopital Saint Joseph /ID# 227221

    Marseille, Bouches-du-Rhone, 13008

  • Cabinet de rhumatologie /ID# 227740

    Mennecy, Essonne, 91540

  • CH Princesse Grace /ID# 222451

    Monaco, 98000

  • Ch Montauban /Id# 231854

    Montauban, 82000

  • ELSAN - Clinique du Pont de Chaume /ID# 224898

    Montauban, 82000

  • Clinique Beau Soleil /ID# 224238

    Montpellier, Herault, 34070

  • CHU Montpellier - Hopital Saint Eloi /ID# 222452

    Montpellier, Herault, 34295

  • CHU Montpellier - Hopital Saint Eloi /ID# 223394

    Montpellier, Herault, 34295

  • CH des Pays de Morlaix /ID# 223795

    Morlaix, Finistere, 29600

  • Polyclinique saint Odilon /ID# 225576

    Moulins, Allier, 03000

  • Ch Mulhouse /Id# 223442

    Mulhouse, 68100

  • CHU de Nantes, Hotel Dieu -HME /ID# 225787

    Nantes, Pays de la Loire Region, 44000

  • CHU Nice -Hopital Pasteur /ID# 222460

    Nice, Provence-Alpes-Côte d'Azur Region, 06002

  • CH Georges Renon /ID# 225197

    Niort, Deux-Sevres, 79028

  • Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 223591

    Orléans, 45067

  • Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 222986

    Paris, Paris, 75679

  • AP-HP - Hopital Saint-Antoine /ID# 222441

    Paris, 75012

  • Hopital Pitie Salpetriere /ID# 222443

    Paris, 75013

  • Cabinet medical /ID# 224855

    Paris, 75014

  • Centre de Soins Osteoarticulaires Ambulatoires /ID# 224737

    Paris, 75015

  • AP-HP - Hopital Bichat - Claude-Bernard /ID# 222449

    Paris, 75018

  • GH Diaconesses Croix Saint-Simon /ID# 229126

    Paris, 75020

  • Cabinet libéral du Dr PAUPIERE /ID# 238723

    Péronne, Somme, 80200

  • HCL - Hopital Lyon Sud /ID# 222447

    Pierre-Bénite, Rhone, 69495

  • Cabinet médical /ID# 225321

    Reims, Marne, 51100

  • CHU de Rennes - Hospital Sud /ID# 222458

    Rennes, 35203

  • CH Roanne /ID# 224729

    Roanne, Pays de la Loire Region, 42300

  • CH Roubaix - Hopital Victor Provo /ID# 225032

    Roubaix, Hauts-de-France, 59100

  • Clinique Saint-Hilaire /ID# 223833

    Rouen, 76000

  • Hôpital Charles-Nicolle /ID# 223589

    Rouen, 76000

  • Hôpital d'instruction des armées Bégin /ID# 222440

    Saint-Mandé, 94163

  • Cabinet Rhumatologie St Michel Sur Orge /ID# 225176

    Saint-Michel-sur-Orge, Essonne, 91240

  • CH Saint Nazaire /ID# 225750

    Saint-Nazaire, 44600

  • Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 222456

    Saint-Priest-en-Jarez, 42270

  • Cabinet rhumatologie Dr NECTOUX /ID# 225828

    Sainte-Maxime, 83120

  • CHU Strasbourg - Hopital de Hautepierre /ID# 222450

    Strasbourg, Bas-Rhin, 67200

  • Groupe Médical Spécialisé - Le Premium /ID# 223719

    Strasbourg, 67000

  • CH Bigorre - Site de la Gespe /ID# 225141

    Tarbes, Hautes-Pyrenees, 65013

  • Cabinet de Rhumatologie Poincare /ID# 224755

    Thionville, Moselle, 57100

  • CHU Toulouse - Hopital Purpan /ID# 223150

    Toulouse, Haute-Garonne, 31059

Other trials in France

Italy29 sites

  • Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo /ID# 228889

    Alessandria, 15100

  • ASL 3 Genovese - Ospedale la Colletta /ID# 228892

    Arenzano, Genova, 16011

  • Azienda Ospedaliera Universitaria Consorziale Policlinico /ID# 228580

    Bari, 70124

  • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni /ID# 228967

    Bergamo, 24127

  • ASST Spedali civili di Brescia /ID# 228970

    Brescia, 25123

  • Ospedale Ss. Annunziata /ID# 228809

    Chieti, 66100

  • Azienda Ospedaliero Universitaria di Ferrara - Ospedale Sant'Anna /ID# 228788

    Cona, Ferrara, 44124

  • Ospedale San Raffaele IRCCS /ID# 229059

    Milan, Milano, 20132

  • ASST Grande Ospedale Metropolitano Niguarda /ID# 228807

    Milan, Milano, 20162

  • ASST Gaetano Pini/Presidio Ospedaliero Pini /ID# 228556

    Milan, 20122

  • Azienda Ospedaliero-Universitaria di Modena /ID# 228554

    Modena, 41124

  • AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 229057

    Naples, 80138

  • Ospedale San Giovanni Bosco /ID# 228552

    Naples, 80144

  • Azienda Ospedaliera Civico Di Cristina Benfratelli- P.O. Civico /ID# 228912

    Palermo, 90127

  • Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 228160

    Palermo, 90127

  • Fondazione IRCCS Policlinico /ID# 227937

    Pavia, 27100

  • Azienda Ospedaliero Universitaria Pisana /ID# 228550

    Pisa, 56126

  • Azienda Ospedaliera Regionale San Carlo /ID# 228648

    Potenza, 85100

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 229061

    Rome, Lazio, 00168

  • Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 229063

    Rome, Roma, 00128

  • Sapienza University /ID# 228014

    Rome, Roma, 00161

  • Azienda Ospedaliero-Universitaria Sant'Andrea /ID# 227942

    Rome, 00189

  • Istituto Clinico Humanitas /ID# 227943

    Rozzano, Milano, 20089

  • Azienda Ospedaliera Universitaria "San Giovanni di Dio e Ruggi d'Aragona /ID# 229065

    Salerno, 84131

  • Azienda Ospedaliero-Universitaria Senese-Ospedale Santa Maria delle Scotte /ID# 227938

    Siena, 53100

  • Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 229440

    Torette, Ancona, 60020

  • Ospedale Mauriziano di Torino /ID# 228888

    Turin, Torino, 10128

  • Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 228551

    Udine, 33100

  • Azienda Ospedaliera Universitaria di Verona/Ospedale Borgo Trento /ID# 228553

    Verona, 37126

Other trials in Italy

Spain28 sites

  • Complejo Hospitalario Universitario A Coruña /ID# 231818

    A Coruña, A Coruna, 15006

  • Hospital Universitario Torrecardenas /ID# 241931

    Almería, 04009

  • Hospital Perpetuo Socorro /ID# 231827

    Badajoz, 06010

  • Hospital Parc de Salut del Mar /ID# 240000

    Barcelona, 08003

  • Hospital Santa Creu i Sant Pau /ID# 231821

    Barcelona, 08041

  • Hospital General de Granollers /ID# 238778

    Barcelona, 08042

  • Hospital Ernest Lluch Martin /ID# 238779

    Calatayud, Zaragoza, 50299

  • Hospital General Universitario Santa Lucia /ID# 238780

    Cartagena, Murcia, 30202

  • Hospital Universitario Reina Sofia /ID# 231843

    Córdoba, Cordoba, 14004

  • Hospital Clinico Universitario Virgen de la Arrixaca /ID# 231847

    El Palmar, Murcia, 30120

  • Hospital Universitario de Getafe /ID# 231825

    Getafe, Madrid, 28905

  • Hospital Universitario Virgen de las Nieves /ID# 231841

    Granada, 18014

  • Hospital Juan Ramon Jimenez /ID# 231840

    Huelva, 21005

  • Hospital Universitario de Jaen /ID# 231842

    Jaén, 23007

  • Hospital Universitario de Jerez de la Frontera /ID# 231844

    Jerez de la Frontera, Cadiz, 11407

  • Hospital Rafael Mendez /ID# 231846

    Lorca, Murcia, 30817

  • Hospital Universitario Ramon y Cajal /ID# 241901

    Madrid, 28034

  • Hospital Universitario Virgen de la Victoria /ID# 240150

    Málaga, 29010

  • Hospital de Mérida /ID# 231826

    Mérida, Badajoz, 06800

  • Hospital Virgen del Puerto /ID# 240149

    Plasencia, Caceres, 10600

  • Hospital Universitario Canarias /ID# 231848

    San Cristóbal de La Laguna, Santa Cruz De Tenerife, 38320

  • Hospital Universitario Virgen Macarena /ID# 231837

    Seville, 41009

  • Hospital Universitario Virgen del Rocio /ID# 231836

    Seville, 41013

  • Hospital Universitario Virgen de Valme /ID# 231838

    Seville, 41014

  • Hospital Universitari Mútua Terrassa /ID# 231822

    Terrassa, Barcelona, 08221

  • Hospital Xeral Cies (CHUVI) /ID# 231819

    Vigo, Pontevedra, 36204

  • Hospital de Viladecans /ID# 231823

    Viladecans, Barcelona, 08840

  • Hospital Royo Villanova /ID# 231824

    Zaragoza, 50015

Other trials in Spain

Germany19 sites

  • ACURA Rheumazentrum Baden-Bade /ID# 225225

    Baden-Baden, 76530

  • Rheumapraxis Prof Dr Karin Manger /ID# 224086

    Bamberg, 96047

  • Praxis fuer Rheumatologie und Innere Medizin /ID# 225222

    Berlin, 12163

  • Eisterhues, Braunschweig, DE /ID# 225186

    Braunschweig, 38100

  • Rheumatologie in Veedel /ID# 224999

    Cologne, 50825

  • Dres. Karger/Baerlecken /ID# 224809

    Cologne, 50996

  • Praxis Dilltal /ID# 226925

    Ehringshausen, 35630

  • MVZ Ambulantes Rheumazentrum Erfurt /ID# 224812

    Erfurt, 99096

  • Helios Fachklinik Vogelsang-Gommern /ID# 222949

    Gommern, 39245

  • Asklepios MVZ Nord SH GmbH /ID# 225048

    Hamburg, 20097

  • Heilig, Heidelberg, DE /ID# 225223

    Heidelberg, 69120

  • Praxis internistische Rheumatologie /ID# 239226

    Leipzig, 04129

  • Dres. Teipel/Toussaint/Saech /ID# 226923

    Leverkusen, 51373

  • Aurich & Sieburg, Magdeburg /ID# 230701

    Magdeburg, 39104

  • Die Fachaerzte im Rottal - Nephrologie, Rheumatologie /ID# 223866

    Pfarrkirchen, 84347

  • MVZ für Rheumatologie Dr. M. Welcker /ID# 226926

    Planegg, 82152

  • Rheumatologische-Immunologische Praxis Templin /ID# 226924

    Templin, Brandenburg, 17268

  • Krankenhaus der Barmherzigen Brüder Trier /ID# 226927

    Trier, 54292

  • Praxis Dr. Haas /ID# 225187

    Tübingen, Baden-Wurttemberg, 72072

Other trials in Germany

Russia18 sites

  • District clinical hospital /ID# 227662

    Khanty-Mansyisk, 628011

  • Moscow Regional Research and Clinical Institute n.a. Vladimirskiy (MONIKI) /ID# 224852

    Moscow, Moscow Oblast, 129110

  • City Clinical Hospital #52 /ID# 242947

    Moscow, 123182

  • Omsk Regional Clinic Hospital /ID# 232029

    Omsk, 644111

  • Orenburg State Medical University /ID# 243615

    Orenburg, 460000

  • Republican hospital named after V.A. Baranov /ID# 227661

    Petrozavodsk, 185019

  • Nort-Western State Medical University n.a. Mechnikov /ID# 223419

    Saint Petersburg, Sankt-Peterburg, 193015

  • Clinical Rheumatologic Hospital No 25 /ID# 242475

    Saint Petersburg, 190068

  • Military Medical Academy n.a. Kirov /ID# 242351

    Saint Petersburg, 194044

  • Samara Regional Clinical Hospital n.a. V. D. Seredavin /ID# 227852

    Samara, Samara Oblast, 443095

  • Clinic of Samara State Medical University /ID# 241168

    Samara, 443079

  • Budgetary Institution of the Khanty-Mansiysk Autonomous Okrug-Yugra Surgut Dist /ID# 243313

    Surgut, 628400

  • LLC MC RevmaMed /ID# 239162

    Syktyvkar, Komi, 167031

  • Nebbiolo Clinical Research Center /ID# 224900

    Tomsk, 634009

  • GBUZ TO Regional Clinical Hospital No. 1 /ID# 241113

    Tyumen, Tyumen Oblast, 625032

  • Ulyanovsk Regional Clinical Hospital /ID# 239164

    Ulyanovsk, 432017

  • Voronezh State Medical Univers /ID# 224854

    Voronezh, 394036

  • Yaroslavl State Medicat University /ID# 224851

    Yaroslavl, 150000

Other trials in Russia

Belgium14 sites

  • Algemeen Stedelijk Ziekenhuis /ID# 224121

    Aalst, Oost-Vlaanderen, 9300

  • Onze Lieve Vrouw Hospital /ID# 223042

    Aalst, 9300

  • AZ Sint-Jan Brugge /ID# 223713

    Bruges, 8000

  • AZ Sint Lucas /ID# 223093

    Bruges, 8310

  • CHU Saint Pierre /ID# 223041

    Brussels, Brussels Capital, 1000

  • Rhumaconsult SPRL /ID# 221825

    Charleroi, Hainaut, 6000

  • Reumacentrum /ID# 222799

    Genk, 3600

  • ReumaClinic /ID# 221353

    Genk, 3600

  • Maertens, Gistel, BE /ID# 221823

    Gistel, 8470

  • Duplicate_CHU UCL Namur - site Godinne /ID# 222797

    Godinne, Namur, 5530

  • Reuma Instituut Hasselt /ID# 221822

    Hasselt, Limburg, 3500

  • CHU de Liege /ID# 222201

    Liège, 4000

  • AZ Alma Campus Sijsele /ID# 222214

    Sijsele, 8340

  • Private practice Sint-Niklaas /ID# 224123

    Sint-Niklaas, Oost-Vlaanderen, 9100

Other trials in Belgium

Greece13 sites

  • University General Hospital of Alexandroupolis /ID# 224880

    Alexandroupoli, Evros, 68100

  • 251 Airforce General Hospital /ID# 225065

    Athens, Attica, 11525

  • General Hospital of Athens Gennimatas /ID# 225064

    Athens, Attica, 11527

  • General Hospital of Athens Ippokratio /ID# 224164

    Athens, Attica, 11527

  • University General Hospital Attikon /ID# 224136

    Athens, Attica, 12462

  • General Hospital Asklepieio Voulas /ID# 224131

    Athens, Attica, 16673

  • Naval Hospital of Athens /ID# 224135

    Athens, 11521

  • University General Hospital of Heraklion PA.G.N.I /ID# 224133

    Heraklion, Crete, 71500

  • Olympion General Clinic /ID# 224130

    Pátrai, Achaia, 25443

  • General Hospital of Patras Agios Andreas /ID# 224132

    Pátrai, 26335

  • Bioclinic Thessaloniki /ID# 224879

    Thessaloniki, 54622

  • General Hospital of Thessaloniki Hippokrateio /ID# 229965

    Thessaloniki, 54642

  • Euromedica General Clinic /ID# 224134

    Thessaloniki, 54645

Other trials in Greece

Argentina9 sites

  • DOM Centro de Reumatologia /ID# 222194

    Buenos Aires, 1111

  • Organizacion Medica de Investigacion (OMI) /ID# 222187

    Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1015

  • CIER Centro de Investigaciones en Enfermedades Reumaticas /ID# 231769

    Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1055

  • Instituto Medico Strusberg /ID# 222189

    Córdoba, 5000

  • Hospital Italiano La Plata /ID# 222190

    La Plata, Buenos Aires, 1902

  • CER Instituto Medico /ID# 222193

    Quilmes, Buenos Aires, 1878

  • Instituto CAICI S.R.L /ID# 222191

    Rosario, Santa Fe Province, 2000

  • CIMER Centro Integral de Medicina Respiratoria /ID# 222188

    San Miguel de Tucumán, Tucumán Province, 4000

  • Instituto de Cardiologia /ID# 226634

    Santiago del Estero, 4200

Other trials in Argentina

Israel9 sites

  • HaEmek Medical Center /ID# 222138

    Afula, H_efa, 1834111

  • Hillel Yaffe Medical Center /ID# 222170

    Hadera, H_efa, 38100

  • Rambam Health Care Campus /ID# 222118

    Haifa, H_efa, 3109601

  • The Lady Davis Carmel Medical Center /ID# 223851

    Haifa, H_efa, 34362

  • Rabin Medical Center /ID# 222694

    Haifa, 4941492

  • Meir Medical Center /ID# 222116

    Kfar Saba, Central District, 4428164

  • Galilee Medical Center /ID# 222113

    Nahariya, Northern District, 2210001

  • The Chaim Sheba Medical Center /ID# 222034

    Ramat Gan, Tel Aviv, 5265601

  • Tel Aviv Sourasky Medical Center /ID# 222117

    Tel Aviv, Tel Aviv, 6423906

Other trials in Israel

Mexico9 sites

  • Centro Integral en Reumatologia S.A de C.V /ID# 224363

    Guadalajara, Jalisco, 44160

  • Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 224361

    Guadalajara, Jalisco, 44650

  • Private Office Dr. Orozco /ID# 243257

    Guadalajara, Jalisco, 44650

  • Centro de Estudios de Investigación Básica y Clínica, S.C. /ID# 224364

    Guadalajara, Jalisco, 44690

  • RM Pharma Specialists S.A de C.V. /ID# 224359

    Mexico City, Mexico City, 03100

  • CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 240836

    Mexico City, Mexico City, 11850

  • Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiova /ID# 224360

    Mexico City, 11650

  • Consultorio Medico Privado - Miryam Eguia Bernal /Id# 243255

    Monterrey, Nuevo León, 64000

  • Consultorio Privado Jorge Rojas Serrano /Id# 243258

    Puebla City, 72550

Other trials in Mexico

Switzerland7 sites

  • Kantonsspital Aarau AG /ID# 222354

    Aarau, Canton of Aargau, 5001

  • Universitätsspital Basel /ID# 224160

    Basel Town, Canton of Basel-City, 4031

  • Inselspital, Universitaetsspital Bern /ID# 224951

    Bern, 3010

  • HFR Fribourg - Hôpital cantonal /ID# 224163

    Fribourg, 1708

  • CHUV, Centre hospitalier universitaire vaudois /ID# 224161

    Lausanne, Canton of Vaud, 1011

  • Kantonsspital St. Gallen /ID# 224158

    Sankt Gallen, Canton of St. Gallen, 9007

  • Rheumatologisches Versorgungszentrum Weinfelden /ID# 222346

    Weinfelden, Thurgau, 8570

Other trials in Switzerland

Austria6 sites

  • Dr. Georg Kurtz /ID# 225477

    Gleisdorf, Styria, 8200

  • Ordination Dr. Leeb /ID# 224293

    Hollabrunn, Lower Austria, 2020

  • Klinikum Klagenfurt am Wörthersee /ID# 239628

    Klagenfurt, Carinthia, 9020

  • Dr. Maya Thun /ID# 224299

    Vienna, State of Vienna, 1010

  • Ordination Doz. Grisar /ID# 224298

    Vienna, State of Vienna, 1090

  • Rheuma-Zentrum Wien-Oberlaa GmbH /ID# 227853

    Vienna, State of Vienna, 1100

Other trials in Austria

Taiwan6 sites

  • Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 241052

    Kaohsiung City, 807

  • China Medical University Hospital /ID# 241051

    Taichung, 40447

  • Chi-Mei Medical Center /ID# 241745

    Tainan, 71004

  • Tri-Service General Hospital /ID# 241746

    Taipei, 11490

  • National Taiwan University Hospital /ID# 241050

    Taipei City, Taipei, 100

  • Linkou Chang Gung Memorial Hospital /ID# 241053

    Taoyuan City, 333

Other trials in Taiwan

Australia5 sites

  • Private Practice - Scott Walter Graf /ID# 223958

    Adelaide, South Australia, 5000

  • Genesis Research Services /ID# 224060

    Broadmeadow, New South Wales, 2292

  • Emeritus Research /ID# 223883

    Camberwell, Victoria, 3124

  • Joint West Rheumatology /ID# 223886

    Murdoch, Western Australia, 6150

  • BJC Health /ID# 223884

    Parramatta, New South Wales, 2150

Other trials in Australia

Saudi Arabia5 sites

  • Saudi German Hospital Jeddah /ID# 243234

    Jeddah, 22236

  • King Abdulaziz University Hospital /ID# 222724

    Jeddah, 22252

  • International Medical Center /ID# 243235

    Jeddah, 22382

  • Saudi German Hospital /ID# 224137

    Mushait, 61961

  • King Fahad Medical City /ID# 222917

    Riyadh, 11525

Other trials in Saudi Arabia

Ireland4 sites

  • St James Hospital /ID# 224201

    Dublin, Dublin, D08 NHY1

  • Hermitage Medical Clinic /ID# 239556

    Dublin, Dublin, D20 W722

  • St Vincent's University Hospital /ID# 224200

    Elm Park, Dublin, D04 T6F4

  • Tallaght University Hospital /ID# 231260

    Tallaght, Dublin, D24 NR0A

Other trials in Ireland

United Arab Emirates4 sites

  • Cleveland Clinic Abu Dhabi /ID# 223176

    Abu Dhabi

  • Integrated Rheumatology and Arthritis Center /ID# 223177

    Dubai, 334224

  • Departnent of Medicine-Rheumatology Al Baraha Hospital and Al Qasmi Hospital Min /ID# 223178

    Dubai

  • Drt Sulaiman Al Habib Hospital /ID# 226575

    Dubai

Other trials in United Arab Emirates

Kuwait3 sites

  • Mubarak Hospital /ID# 224139

    Hawalli, 46300

  • Ameeri Hospital /ID# 224140

    Kuwait City, 35002

  • KOC Hospital /ID# 224138

    Kuwait City, 60000

Other trials in Kuwait

Uruguay2 sites

  • Asociacion Española /ID# 222009

    Montevideo, 11200

  • Medica Uruguaya /ID# 222008

    Montevideo, 11600

Other trials in Uruguay

About this study

Official title: Upadacitinib Treatment Patterns, Achievement of Treatment Targets and Maintenance of Response in Moderate to Severe Rheumatoid Arthritis Patients in Real-World Practice (UPHOLD)

Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. Despite the range of treatment options for RA steadily increasing, many patients remain sub-optimally managed, with sustained clinical remission rarely achieved. This study will assess the treatment patterns, achievement of treatment targets and maintenance of response.

Upadacitinib is a drug approved for the treatment of moderately to severely active rheumatoid arthritis. Adult participants with moderate to severe RA who have been prescribed upadacitinib by their physicians will be enrolled. Approximately, 1660 participants will be enrolled this study, worldwide.

Read more

Participants will not receive Upadacitinib as part of this study, but will be followed for response to treatment for up to 24 months.

There may be higher burden for participants in this trial compared to their standard of care. Participants will attend regular visits, every 3 months, during the course of the study at a hospital or clinic and will be asked to provide additional information by questionnaire at each visit.

Keywords
Rheumatoid Arthritis, Upadacitinib, RINVOQ
Medical subject headings
Arthritis, Rheumatoid

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT04497597
Study groupRoleWhat they receive
Participants receiving UpadacitinibParticipants receiving Upadacitinib for moderate to severe rheumatoid arthritis (RA).

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Percentage of Participants Who Achieve Remission

    Remission is defined as Disease Activity Score at 28 joints (DAS28) C-reactive Protein (CRP)<2.6.

    Measured: At Month 6

  2. Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission

    Remission is defined as DAS28-CRP<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.

    Measured: At Month 12

Secondary outcomes (23)

  1. Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission

    Remission is defined as DAS28-CRP<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.

    Measured: At Month 24

  2. Percentage of Participants Who Achieve Low Disease Activity (LDA) at 6 months that maintain LDA

    LDA is defined as DAS28-CRP≤3.2. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.

    Measured: Through Month 24

  3. Percentage of Participants Who Achieve Remission at 3 Months and Maintain Remission

    Remission is defined as DAS28-CRP<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.

    Measured: Through Month 24

  4. Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission Grouped by Glucocorticoid Dose

    Remission is defined as DAS28-CRP<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.

    Measured: At Month 12

  5. Percentage of Participants Who Achieve LDA at 3 months that maintain LDA Grouped by Glucocorticoid Dose

    LDA is defined as DAS28-CRP≤3.2. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.

    Measured: Through Month 6

  6. Percentage of Participants in LDA that Achieve Glucocorticoid Dose <5 mg/Day Per Visit

    LDA is defined as DAS28-CRP<3.2.

    Measured: Through Month 24

  7. Percentage of Participants in Remission that Achieve Glucocorticoid Dose <5 mg/Day Per Visit

    Remission is defined as DAS28-CRP<2.6.

    Measured: Through Month 24

  8. Percentage of Participants Who Achieved a Glucocorticoid Dose <5 mg/Day Without Conventional Synthetic Disease Modifying Anti Rheumatic Drug (csDMARD) Intensification

    Percentage of participants who achieved a glucocorticoid dose <5 mg/day without csDMARD intensification.

    Measured: At Month 6

  9. Percentage of Participants Who Initiated Upadacitinib as Combination Therapy (csDMARD +/- Glucocorticoids) That Moved to Monotherapy (+/- Glucocorticoids)

    Percentage of participants who initiated Upadacitinib as combination therapy (csDMARD +/- Glucocorticoids) that moved to monotherapy (+/- glucocorticoids).

    Measured: Through Week 24

  10. Of the Participants Initiating Upadacitinib as Combination Therapy (csDMARD +/- Glucocorticoids) and Achieve Remission at 6 months, the Percentage of Participants that Maintain Remission Grouped by Maintenance of Combination Therapy Strategy

    Remission is defined as DAS28-CRP<2.6.

    Measured: Through Month 24

  11. Of the Participants Initiating Upadacitinib as Combination Therapy (csDMARD +/- Glucocorticoids) and Achieve LDA at 6 months, the Percentage of Participants that Maintain LDA Grouped by Maintenance of Combination Therapy Strategy

    LDA is defined as DAS28-CRP<3.2.

    Measured: Through Month 24

  12. Of the Participants Initiating Upadacitinib as Monotherapy Therapy (+/- Glucocorticoids) and Achieve Remission at 6 months, the Percentage of Participants that Maintain Remission Grouped by Maintenance of Monotherapy

    Remission is defined as DAS28-CRP<2.6.

    Measured: Through Month 24

  13. Of the Participants Initiating Upadacitinib as Monotherapy Therapy (+/- Glucocorticoids) and Achieve LDA at 6 months, the Percentage of Participants that Maintain LDA Grouped by Maintenance of Monotherapy

    LDA is defined as DAS28-CRP<3.2.

    Measured: Through Month 24

  14. Percentage of Participants Who Do Not Achieve Remission at Any Point in the Study

    Remission is defined as DAS28-CRP<2.6.

    Measured: Through Month 24

  15. Time to the Discontinuation of Upadacitinib

    Time to the discontinuation of Upadacitinib.

    Measured: Through Month 24

  16. Time to First Treatment Adjustment

    Treatment Adjustment is defined as treatment escalation/de-escalation/ addition/withdrawal.

    Measured: Baseline (Month 0) Through Month 24

  17. Percentage of Participants Achieving LDA Grouped by Therapy Strategy

    LDA is defined as DAS28-CRP<3.2, Simplified Disease Activity Index (SDAI) ≤11 and Clinical Disease Activity Index (CDAI) ≤10.

    Measured: Through Month 24

  18. Percentage of Participants Achieving Remission Grouped by Therapy Strategy

    Remission is defined as DAS28-CRP<2.6, SDAI≤3.3 and CDAI ≤2.8.

    Measured: Through Month 24

  19. Change in Medication Burden Treatment Burden Questionnaire (TBQ) in Participants, Grouped by Therapy Strategy

    The TBQ is composed of 13 items rated on a Likert scale ranging from 0 (not a problem), to 10 (big problem). scores can be summed into a global score, ranging from 0 to 130.

    Measured: Through Week 24

  20. Change in Physical Function Health Assessment Questionnaire - Disability Index (HAQ-DI) in Participants, Grouped by Therapy Strategy

    HAQ is a widely accepted, validated, rheumatology specific instrument to assess physical function in Rheumatoid Arthritis. It consists of 20 questions, covering eight types of activities. For each question, scores range from 0 to 3 (0 = without any difficulty; 1 = with some difficulty; 2 = with much difficulty or with assistance; 3 = unable to do). HAQ Disability Index (HAQ-DI) score is the average of the highest score in each of the eight categories.

    Measured: Baseline (Month 0) Through Month 24

  21. Change in Pain Visual Analogue Scale (VAS) in participants, Grouped by Therapy Strategy

    A VAS is used to assess worst joint pain in the past 7 days.

    Measured: Baseline (Month 0) Through Month 24

  22. Change in Morning Stiffness in Participants, Grouped by Therapy Strategy

    A numeric rating scale (NRS) is used to assess severity and length of morning stiffness in the past 7 days.

    Measured: Baseline (Month 0) Through Month 24

  23. Change in Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) in Participants, Grouped by Therapy Strategy

    The FACIT Fatigue Scale is a short, 13-item, easy to administer tool that measures an individual's level of fatigue during their usual daily activities over the past week. The level of fatigue is measured on a four-point Likert scale (0 = not at all fatigued to 4 = very much fatigued).

    Measured: Baseline (Month 0) Through Month 24

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted4 Aug 2020
  2. Study start16 Oct 2020
  3. Primary completion15 May 2024
  4. Study completion15 May 2024

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
1,532 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT04497597
Sponsor's protocol ID
P20-095
Acronym
UPHOLD
Status last verified
Apr 2025
First submitted
30 Jul 2020
Last updated
13 Apr 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

Publications

  • Baldi C, Celletti E, Bugatti S, Govoni M, Cazzato M, Picchianti Diamanti A, Fornaro M, Guggino G, Navarini L, D'Agostino MA, Quartuccio L, Ciccia F, Dagna L, Stobbione P, Triggiani M, Viapiana O, Giardina A, Moroncini G, Caporali R, Bazzani C, Tirri E, Lomater C, Di Fino S, Morello F, Selmi C. Achievement and Maintenance of Remission with Upadacitinib in Patients with Moderate-to-Severe Rheumatoid Arthritis in Italy: 1-Year Data from UPHOLD, a Prospective Real-World Observational Study. Rheumatol Ther. 2026 Jun;13(3):767-784. doi: 10.1007/s40744-026-00845-2. Epub 2026 Apr 12.

    PubMed 41968259

  • Ostor A, Feist E, Sidiropoulos P, Avouac J, Rebella M, Namas R, Buttgereit F, Conaghan PG, Romero AB, McDearmon-Blondell EL, Lagunes-Galindo I, Gao T, Kadakia A, Shaw T, Attar S. Achievement and Maintenance of Disease Targets with Upadacitinib in Rheumatoid Arthritis: 2-Year Outcomes from the UPHOLD Real-World Study. Rheumatol Ther. 2026 Jun;13(3):659-676. doi: 10.1007/s40744-026-00826-5. Epub 2026 Mar 19.

    PubMed 41854829

  • Hugle T, Prillwitz H, Scholz G, Kyburz D, Dudler J, Schmiedeberg K, Zanisi L, Harrer Kuster MD, Roulin PS, Rubbert-Roth A. Sleep improvement in patients with rheumatoid arthritis treated with upadacitinib in real-world practice: results from the SLEERA study. Arthritis Res Ther. 2026 Feb 27;28(1):80. doi: 10.1186/s13075-026-03766-1.

    PubMed 41761286

  • Ostor A, Feist E, Sidiropoulos P, Avouac J, Rebella M, Namas R, McDearmon-Blondell E, Gao T, Lagunes-Galindo I, Strengholt S, Zisman D, Attar S. Achievement of treatment targets and maintenance of response with upadacitinib in patients with moderate-to-severe rheumatoid arthritis in real-world practice: 1-year outcomes from the UPHOLD observational study. Arthritis Res Ther. 2025 Apr 10;27(1):84. doi: 10.1186/s13075-025-03528-5.

    PubMed 40211417

Questions about this trial

What is this clinical trial studying?

An observational study of Rheumatoid Arthritis (RA), run by AbbVie at 263 sites in 19 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 13 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 263 sites in France, Italy, Spain, Germany, Russia and 14 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Percentage of Participants Who Achieve Remission (time frame: At Month 6). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT04497597, which also lists 4 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2025.

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