AzTrials
AzTrials

Heart FailurePhase 3FINEARTS-HFNCT04435626

Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%

A Phase 3 study testing Finerenone (BAY94-8862) in people with Heart Failure, run by Bayer at 661 sites in 37 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits… Read more about this study

Who is it for?
Ages 40 years and older
Conditions the study is for
Heart Failure
What is being tested?
Finerenone (BAY94-8862)
Type of treatment
Pill or oral medicine
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
6,016 participants
Where
661 sitesin 37 countries
Study dates
14 Sep 2020to 14 Jun 2024
Phase
Phase 3
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 40 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Participant (male or female) must be aged 40 years and older.
  • Diagnosis of heart failure with New York Heart Association(NYHA) class II-IV, ambulatory or hospitalized primarily for heart failure.
  • On diuretic treatment for at least 30 days prior to randomization.
  • Documented left ventricular ejection fraction (LVEF) of ≥40% measured by any modality within the last 12 months.
  • Structural heart abnormalities based on any local imaging measurement within the last 12 months, defined by at least one of the following findings: left atrial diameter (LAD) ≥3.8cm, left atrial area (LAA) ≥20cm2, left atrial volume index (LAVI) >30 mL/m2, left ventricular mass index (LVMI) ≥115 g/m2 (♂)/ 95 g/m2 (♀), septal thickness or posterior wall thickness ≥1.1 cm
  • n-terminal prohormone B-type natriuretic peptide (NT-proBNP) ≥300 pg/mL (BNP ≥100 pg/mL) in sinus rhythm and patient does not have an ongoing diagnosis of paroxysmal atrial fibrillation or NT-proBNP ≥900 pg/mL (BNP ≥300 pg/mL) in atrial fibrillation (or if atrial fibrillation status is unknown or if patient has an ongoing diagnosis of paroxysmal atrial fibrillation) for participants obtained at the following time:
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  • Within 90 days prior to randomization if patient had been hospitalized for heart failure (HF) requiring initiation or change in HF therapy or if patient had an urgent visit for HF requiring intravenous (IV) diuretic therapy, both within 90 days prior to randomization OR
  • Within 30 days prior to randomization if patient has not been hospitalized for HF nor had an urgent HF visit within the past 90 days.
  • Women of childbearing potential can only be included in the study if a pregnancy test is negative at screening and baseline and if they agree to use adequate contraception which is consistent with local regulations regarding the methods for contraception for those participating in clinical trials.

Who cannot join

  • Estimated glomerular filtration rate (eGFR) <25 mL/min/1.73 m² at either screening or randomization visit.
  • Serum/plasma potassium >5.0 mmol/L at either screening or randomization visit.
  • Acute inflammatory heart disease, e.g. acute myocarditis, within 90 days prior to randomization
  • Myocardial infarction or any event which could have reduced the ejection fraction within 90 days prior to randomization
  • Coronary artery bypass graft surgery in the 90 days prior to randomization
  • Percutaneous coronary intervention in the 30 days prior to randomization
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  • Stroke or transient ischemic cerebral attack within 90 days prior to randomization
  • Probable alternative cause of participants' HF symptoms that in the opinion of the investigator primarily accounts for patient's dyspnea such as significant pulmonary disease, anemia or obesity. Specifically, patients with the below are excluded: Severe pulmonary disease requiring home oxygen, or chronic oral steroid therapy, History of primary pulmonary arterial hypertension, Hemoglobin <10 g/dl, Valvular heart disease considered by the investigator to be clinically significant, Body Mass Index (BMI) >50 kg/m2 at screening
  • Systolic blood pressure(SBP) ≥160 mmHg if not on treatment with ≥3 blood pressure lowering medications or ≥180 mmHg irrespective of treatments, on 2 consecutive measurements at least 2-minute apart, at screening or at randomization.
  • Concomitant systemic therapy with potent cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors (e.g. itraconazole, ritonavir, indinavir, cobicistat, clarithromycin) or moderate or potent CYP3A4 inducers, that cannot be discontinued 7 days prior to randomization and for the duration of the treatment period.

Trial locations and contacts

661 sites in 37 countries.

661 sites in 37 countries

United States107 sites

  • VA Eastern Colorado Health Care System

    Aurora, Colorado, 80045

  • Ascension Seton Heart Specialty Care and Transplant Center

    Austin, Texas, 78705

  • Johns Hopkins Hospital - Cardiology

    Baltimore, Maryland, 21287

  • Suburban Hospital - Cardiology

    Bethesda, Maryland, 20814

  • WestSide Medical

    Beverly Hills, California, 90211

  • Cardiology, PC

    Birmingham, Alabama, 35211

  • Cardiovascular & Vein Center of Florida | Bradenton, FL

    Bradenton, Florida, 34209

  • Nova Clinical Research - Blake Medical Center

    Bradenton, Florida, 34209

  • Advanced Heart Care, LLC | Bridgewater, NJ

    Bridgewater, New Jersey, 08807

  • Kernodle Clinic West

    Burlington, North Carolina, 27215

  • Capital Area Research | Camp Hill, PA

    Camp Hill, Pennsylvania, 17011

  • University of North Carolina

    Chapel Hill, North Carolina, 27514

  • Advocate Illinois Masonic Medical Center - Cardiology

    Chicago, Illinois, 60657

  • Colorado Springs Cardiology - Woodmen Medical Plaza

    Colorado Springs, Colorado, 80923

  • Cardiovascular Specialists of Central Maryland, PA

    Columbia, Maryland, 21044

  • Harry S Truman Memorial Veterans Hospital - Cardiology

    Columbia, Missouri, 65201

  • Centricity Research at Talbotton

    Columbus, Georgia, 31904

  • Cardiovascular Associates Research, LLC

    Covington, Louisiana, 70433

  • Texas Health & Vascular Specialists - Dallas

    Dallas, Texas, 75231

  • Southwest Family Medicine Associates | Dallas, TX

    Dallas, Texas, 75235

  • Cardiology Associates Research Company

    Daytona Beach, Florida, 32117

  • Henry Ford Hospital - OB/GYN

    Detroit, Michigan, 48202

  • Advocate Good Samaritan Hospital - Cardiology

    Downers Grove, Illinois, 60515

  • Doylestown Health Cardiology - DCA

    Doylestown, Pennsylvania, 18901

  • Midwest Cardiovascular Research and Education Foundation | Elkhart, IN

    Elkhart, Indiana, 46514

  • Inova Cardiology- Fairfax

    Fairfax, Virginia, 22031

  • Eastern Shore Research Institute, LLC | Fairhope, AL

    Fairhope, Alabama, 36532

  • Virginia Heart

    Falls Church, Virginia, 22042

  • AA Medical Research Center | Flint, MI

    Flint, Michigan, 48504

  • Texas Health Family Care - W Vickery Blvd

    Fort Worth, Texas, 76107

  • North Florida Foundation for Research and Education - Clinical Trial Center

    Gainesville, Florida, 32608

  • University of Texas Medical Branch at Galveston

    Galveston, Texas, 77555

  • The Stern Cardiovascular Foundation - Germantown, TN

    Germantown, Tennessee, 38138

  • CHI Health Clinic Heart Institute - Grand Island

    Grand Island, Nebraska, 68803

  • Heart Clinic of Hammond

    Hammond, Louisiana, 70403

  • Houston Heart & Vascular Associates

    Humble, Texas, 77338

  • CA Heart and Vein Specialists

    Huntington Beach, California, 92648

  • Baptist Heart -Cardiology - DCT Dept

    Jackson, Mississippi, 39202

  • University Hospital - UMMC - Nephrology

    Jackson, Mississippi, 39216

  • Apex Research Foundation, LLC. | Jackson, TN

    Jackson, Tennessee, 38301

  • Logan Health Research

    Kalispell, Montana, 59901

  • Clinical Research Consultants

    Kansas City, Missouri, 64111

  • Saint Luke's Mid America Heart Institute

    Kansas City, Missouri, 64111

  • South Texas Cardiovascular Consultants, PLLC / Kerrville, TX

    Kerrville, Texas, 78028

  • Kettering Health Network | Research Institute

    Kettering, Ohio, 45429

  • Trident Cardiology Associates, PA

    Ladson, South Carolina, 29456

  • Carolina Heart Specialists | Lancaster, SC

    Lancaster, South Carolina, 29720

  • Virginia Heart - Leesburg

    Leesburg, Virginia, 20176

  • Advocate Condell Medical Center

    Libertyville, Illinois, 60048

  • CHI Health Nebraska Heart

    Lincoln, Nebraska, 68526

  • NJ Heart | Linden, NJ

    Linden, New Jersey, 07036

  • Heart Clinic Arkansas

    Little Rock, Arkansas, 72205

  • South Denver Cardiology Associates, PC

    Littleton, Colorado, 80120

  • William S. Middleton Memorial Veterans Hospital

    Madison, Wisconsin, 53705

  • Garden State Heart Care

    Manalapan, New Jersey, 07726

  • M Health Fairview Heart Clinic - Maplewood

    Maplewood, Minnesota, 55109

  • Rama Research LLC | Marion, OH

    Marion, Ohio, 43302-6774

  • North Dallas Research Associates

    McKinney, Texas, 75069

  • Lt. Col. Luke Weathers, Jr. VA Medical Center - Cardiology

    Memphis, Tennessee, 38105

  • LifeSpring Research Foundation, LLC

    Miami, Florida, 33130

  • Aurora Saint Luke's Medical Center - Cardiology

    Milwaukee, Wisconsin, 53215

  • M Health Fairview Heart Clinic - Fulton

    Minneapolis, Minnesota, 55455

  • Mobile Heart Specialists - Providence

    Mobile, Alabama, 36608

  • Edward Hospital - Main Campus - Cardiology

    Naperville, Illinois, 60540

  • Southwest Florida Research | Naples, FL

    Naples, Florida, 34102-8143

  • Sentara Norfolk General Hospital

    Norfolk, Virginia, 23507

  • Captain James A. Lovell Federal Health Care Center

    North Chicago, Illinois, 60064

  • South Oklahoma Heart Research, LLC

    Oklahoma City, Oklahoma, 73135

  • UCI Medical Center - Neurology

    Orange, California, 92868

  • Baptist Health Paducah - Cardiology

    Paducah, Kentucky, 42003

  • Carle Health Methodist Hospital - Cardiology

    Peoria, Illinois, 61603

  • ClinRx Research, LLC

    Plano, Texas, 75024

  • Nuvance Health - The Heart Center

    Poughkeepsie, New York, 12601

  • Cardiovascular Research of Knoxville

    Powell, Tennessee, 37849

  • Monument Health Clinical Research

    Rapid City, South Dakota, 57701

  • Reid Physicians Associates - Cardiology Department

    Richmond, Indiana, 47374

  • Division of Cardiovascular Research at Peconic Bay Medical Center

    Riverhead, New York, 11901

  • Laurelton Heart Specialists

    Rosedale, New York, 11422

  • Sutter Medical Center - Cardiology

    Sacramento, California, 95816

  • East Coast Institute for Research | St. Augustine, FL

    Saint Augustine, Florida, 32086

  • St. Cloud Hospital

    Saint Cloud, Minnesota, 56303

  • Salem VA Medical Center - Cardiology

    Salem, Virginia, 24153

  • University of Utah Clinical Neurosciences Center

    Salt Lake City, Utah, 84312

  • South Texas Cardiovascular Consultants - San Antonio

    San Antonio, Texas, 78201

  • Clinical Advancement Center, PLLC

    San Antonio, Texas, 78212

  • NorthBay Clinical Research, LLC | Santa Rosa, CA

    Santa Rosa, California, 95405

  • Saratoga Clinical Research, LLC

    Saratoga Springs, New York, 12866

  • MaineHealth Cardiology - Scarborough

    Scarborough, Maine, 04039

  • Sanford USD Medical Center - Cardiology

    Sioux Falls, South Dakota, 57105

  • Louisiana Heart Center - Slidell

    Slidell, Louisiana, 70458

  • Mercy Hospital Springfield - Cardiology

    Springfield, Missouri, 65804

  • Cardiac Care & Vascular Medicine

    The Bronx, New York, 10469

  • Northwest Houston Clinical Research - Tomball

    Tomball, Texas, 77375

  • The Lundquist Institute - Gynecology

    Torrance, California, 90502

  • Atlanta Heart Specialists - Tucker

    Tucker, Georgia, 30084

  • University of Arizona Clinical and Translational Sciences Research Center

    Tucson, Arizona, 85724

  • Northwell Health Physician Partners Cardiology at Valley Stream

    Valley Stream, New York, 11580

  • Blue Coast Research Center, LLC

    Vista, California, 92081

  • Kent Hospital

    Warwick, Rhode Island, 02886

  • Cardiology Partners Clinical Research Institute | Wellington Office

    Wellington, Florida, 33449

  • Interventional Cardio Medical- DCT Department

    West Hills, California, 91307

  • Interventional Cardiology Medical Group | West Hills, CA

    West Hills, California, 91307

  • Kansas Nephrology Research Institute

    Wichita, Kansas, 67214

  • Selma Medical Associates

    Winchester, Virginia, 22601

  • Wake Forest Baptist Health

    Winston-Salem, North Carolina, 27157

  • Mercy Health - St. Elizabeth Youngstown Hospital

    Youngstown, Ohio, 44501

  • Southern Clinical Research, LLC

    Zachary, Louisiana, 70791

Other trials in United States

Japan47 sites

  • Nishiarai Heart Central Clinic

    Adachi-ku, Tokyo, 123-0845

  • Ageo Central General Hospital

    Ageo, Saitama, 362-8588

  • Japan Red Cross Society Azumino Hospital

    Azumino, Nagano, 399-8292

  • Fukuoka University Nishijin Hospital

    Fukuoka, 814-8522

  • Funabashi Municipal Medical Center

    Funabashi, Chiba, 273-8588

  • Gifu Prefectural General Medical Center

    Gifu, 500-8717

  • Minamino Cardiovascular Hospital

    Hachiōji, Tokyo, 192-0918

  • Public Central Hospital of Matto Ishikawa | Clinical Trial Management Office

    Hakusan, Ishikawa-ken, 924-8588

  • National Hospital Organization Hamada Medical Center

    Hamada, Shimane, 697-8511

  • Hyogo Prefectural HarimaHimeji General Medical Center

    Himeji, Hyōgo, 670-8560

  • National Hospital Organization Iwakuni Clinical Center

    Iwakuni, Yamaguchi, 740-8510

  • National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office

    Kanazawa, Ishikawa-ken, 920-8650

  • Kasugai Municipal Hospital

    Kasugai, Aichi-ken, 486-8510

  • Kawaguchi Cardiovascular and Respiratory Hospital

    Kawaguchi, Saitama, 333-0842

  • Kishiwada Tokushukai Hospital

    Kishiwada, Osaka, 596-0042

  • Steel Memorial Yawata Hospital

    Kitakyushu, Fukuoka, 805-8508

  • National Hospital Organization Kobe Medical Center

    Kobe, Hyōgo, 654-0155

  • National Hospital Organization Kumamoto Medical Center

    Kumamoto, 860-0008

  • Kumamoto University Hospital

    Kumamoto, 860-8556

  • National Hospital Organization Tokyo Medical Center

    Meguro-ku, Tokyo, 152-8902

  • Miyazaki Medical Association Hospital

    Miyazaki, 880-2102

  • Iwate Prefectural Central Hospital

    Morioka, Iwate, 020-0066

  • R.I.A.C Naha City Hospital

    Naha, Okinawa, 902-8511

  • Shinrakuen Hospital

    Niigata, 950-2087

  • Ogaki Municipal Hospital

    Ōgaki, Gifu, 503-8502

  • Oita Prefectural Hospital

    Ōita, 870-8511

  • The Sakakibara Heart Institute of Okayama

    Okayama, 700-0804

  • Onga Nakama Medical Association Onga Hospital

    Onga-gun, Fukuoka, 811-4342

  • Osaka Police Hospital | Clinical Research and Trial Center

    Osaka, 543-0035

  • Osaka General Medical Center

    Osaka, 558-8558

  • Social Corporation Keigakukai Minamiosaka Hospital

    Osaka, 559-0012

  • Toho University Omori Medical Center

    Ōta-ku, Tokyo, 143-8541

  • Kitasato University Hospital

    Sagamihara, Kanagawa, 252-0375

  • Sagamihara Kyodo Hospital

    Sagamihara, Kanagawa, 252-5188

  • Saitama Sekishinkai Hospital

    Sayama, Saitama, 350-1305

  • JCHO Shimonoseki Medical Center

    Shimonoseki, Yamaguchi, 750-0061

  • Shobara Red Cross Hospital

    Shōbara, Hiroshima, 727-0013

  • Kagawa Prefectural Central Hospital

    Takamatsu, Kagawa-ken, 760-8557

  • Higashi Takarazuka Satoh Hospital

    Takarazuka, Hyōgo, 665-0873

  • Takatsuki Red Cross Hospital

    Takatsuki, Osaka, 569-1045

  • JA Toride Medical Center

    Toride, Ibaraki, 302-0022

  • Toyama University Hospital

    Toyama, 930-0194

  • Mitoyo General Hospital | Kagawa, Japan

    Toyohama-Cho,Kanonji-City, Kagawa-ken, 769-1695

  • TOYOTA Memorial Hospital

    Toyota, Aichi-ken, 471-8513

  • National Hospital Organization Shinshu Ueda Medical Center

    Ueda, Nagano, 386-8610

  • Seiyu Memorial Hospital

    Wakayama, 649-6335

  • Japan Organization of Occupational Health and Safety Sanin Rosai Hospital

    Yonago, Tottori, 683-8605

Other trials in Japan

China45 sites

  • Beijing Anzhen Hospital, Capital Medical University

    Beijing, 100029

  • Beijing Friendship Hospital, Capital Medical University

    Beijing, 100050

  • Beijing Tsinghua Changgung Hospital

    Beijing, 102218

  • Jilin Province People's Hospital

    Changchun, Jilin, 130021

  • The First Hospital of Jilin University

    Changchun, Jilin, 130061

  • The Third Xiangya Hospital of Central South University

    Changsha, Hunan, 410000

  • Changsha Central Hospital

    Changsha, Hunan, 410004

  • Hunan Provincial People's Hospital

    Changsha, Hunan, 410005

  • West China Hospital Sichuan University

    Chengdu, Sichuan, 610041

  • SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos

    Chengdu, Sichuan, 610072

  • Daqing Oilfield General Hospital

    Daqing, Heilongjiang, 163311

  • Fujian Provincial Hospital

    Fuzhou, Fujian, 350001

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangdong, 510000

  • The First Affiliated Hospital of Sun Yat-Sen University

    Guangzhou, Guangdong, 510080

  • Sun Yat-Sen Memorial Hosp. Sun Yat-Sen Univ.

    Guangzhou, Guangdong, 510120

  • The First Affiliated Hospital of Guangzhou University of TCM

    Guangzhou, Guangdong, 510405

  • Nanfang Hospital, Southern Medical University

    Guangzhou, Guangdong, 510515

  • The First Affiliated Hospital of Jinan University

    Guangzhou, Guangdong, 510630

  • Guizhou Provincial People's Hospital

    Guiyang, Guizhou, 550002

  • Hainan Provincial People's Hospital

    Haikou, Hainan, 570311

  • 1st Affiliated Hospital of College Medicine, Zhejiang Univ.

    Hangzhou, Zhejiang, 310003

  • Huai'an First People's Hospital, Nanjing Medical University

    Huai'an, Jiangsu, 223300

  • Jinan Central Hospital

    Jinan, Shandong, 250013

  • Lanzhou University Second Hospital

    Lanzhou, Gansu, 730030

  • The First People's Hospital of Lianyungang

    Lianyungang, Jiangsu, 222002

  • The Second Affiliated Hospital of Nanjing Medical university

    Nanjing, Jiangsu, 210000

  • NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School

    Nanjing, Jiangsu, 210008

  • Zhongda Hospital Southeast University

    Nanjing, Jiangsu, 210009

  • Jiangsu Province Hospital

    Nanjing, Jiangsu, 210029

  • Nanjing Jiangning Hospital

    Nanjing, Jiangsu, 211103

  • Panjin Liaohe Oilfield Gem Flower Hospital

    Panjin, Liaoning, 124010

  • Hainan Third People's Hospital (Province Nongken Sanya Hopt)

    Sanya, Hainan, 572000

  • Shanghai Tongji Hospital of Tongji University

    Shanghai, 200065

  • Shanghai East Hospital Affiated to Tongji University

    Shanghai, 200100

  • The First Hospital of Hebei Medical Univesity

    Shijiazhuang, Hebei, 050000

  • 1st Affiliated hospital of Soochow University

    Suzhou, Jiangsu, 215000

  • Shanxi Provincial People's Hospital

    Taiyuan, Shanxi, 030012

  • Tianjin People's Hospital

    Tianjin, 300000

  • People's Hospital of Xinjiang Uygur Autonomous Region

    Ürümqi, Xinjiang, 830001

  • The First Affiliated Hospital of Xinjiang Medical University

    Ürümqi, Xinjiang, 830011

  • Shaanxi Provincial People's Hospital

    Xi'an, Shaanxi, 710068

  • The First Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, Shaanxi Sheng, 710061

  • Xinxiang Central Hospital

    Xinxiang, Henan, 453000

  • Yinchuan No.1 People's Hospital

    Yinchuan, Ningxia, 750001

  • General Hospital of Ningxia Medical University

    Yinchuan, Ningxia, 750004

Other trials in China

Russia28 sites

  • SBHI of Sverdlovsk Region Aramil City Hospital

    Aramil, 624003

  • First City Clinical Hospital n.a. E.E. Volosevich

    Arkhangelsk, 163001

  • Altai Regional Cardiological Dispensary

    Barnaul, 656055

  • SBEI "Chita State Medical Academy"

    Chita, 672000

  • Izhevsk City Clinical Hospital #9

    Izhevsk, 426063

  • Kazan Federal University

    Kazan', 420043

  • Clinical Diagnostic Center

    Kazan', 420101

  • Sci-Res. Institute of Complex Cardiovascular Disorders

    Kemerovo, 650002

  • Center of cardiology and neurology

    Kirov, 610014

  • Research center of therapy and prophylactic medicine

    Moscow, 101990

  • City Clinical Hospital #29 n.a. N.E. Bauman - Clinical-Diagnostic dept

    Moscow, 111020

  • City clinical hospital n.a. V.V. Vinogradov

    Moscow, 117292

  • Moscow State University n.a. M.V. Lomonosov

    Moscow, 119192

  • Russian Clinical and Research Center of Gerontology

    Moscow, 129226

  • State Novosibirsk Regional Clinical Hospital

    Novosibirsk, 630087

  • Omsk Region "Clinical Health Unit No. 9"

    Omsk, 644018

  • Penza Regional Clinical Hospital n.a. N.N. Burdenko

    Penza, 440026

  • Perm Regional Hospital for War Veterans

    Perm, 614097

  • Rostov-on-Don Emergency Clinical Hospital

    Rostov-on-Don, 344068

  • SBI of the Ryazan region "Regional clinical hospital"

    Ryazan, 390039

  • Scien. Res. Inst. of Emergency Care n.a. I.I. Dzhanelidze

    Saint Petersburg, 192242

  • St. Petersburg Clinical Hospital of RAS

    Saint Petersburg, 194017

  • LLC Astarta

    Saint Petersburg, 199226

  • Samara Regional Clinical Cardiology Dispensary n.a. Polyakov

    Samara, 443070

  • Clinical Hospital #3 n.a. S.R. Mirotvortsev

    Saratov, 410054

  • Scientific Research Institute of Cardiology

    Tomsk, 634012

  • Tomsk Regional Clinical Hospital

    Tomsk, 634063

  • Sverdlovsk Regional Clinical Hospital #1

    Yekaterinburg, 620102

Other trials in Russia

Czechia23 sites

  • Fakultní nemocnice Brno - Interní kardiologická klinika

    Brno, South Moravian, 625 00

  • Kardiologie MUDr. Libor Nechvatal s.r.o.

    Brno, 602 00

  • Kardiologicka ambulance Brno s.r.o.

    Brno, 612 00

  • Kardiologicka ambulance

    Český Krumlov, 381 01

  • Kardio Chlumec s.r.o.- Kardiologicka ambulance

    Chlumec nad Cidlinou, 503 51

  • Poliklinika Dolní Brežany

    Dolní Břežany, 252 41

  • Fakultní Nemocnice Hradec Kralové

    Hradec Králové, 500 05

  • Kromerizska nemocnice a.s.

    Kroměříž, 767 01

  • LUNACOR, Centrum pro choroby srdce a cev

    Kroměříž, 767 01

  • Krajska Nemocnice Liberec

    Liberec, 460 63

  • KardioBusak s.r.o.

    Louny, 440 01

  • Fakultni nemocnice Plzen

    Pilsen, 301 00

  • Kardiologicka a interni ambulance

    Písek, 39701

  • Polabska zdravotni, s.r.o.

    Poděbrady, 290 01

  • Všeobecná fakultní nemocnice v Praze - II. interní klinika - klinika kardiologie a angiologie

    Prague, 12808

  • Institut Klinicke a Experimentalni Mediciny

    Prague, 140 21

  • Fakultní nemocnice v Motole

    Prague, 150 06

  • Ustredni vojenska nemocnice Praha

    Prague, 169 02

  • Affidea Praha s.r.o - Kardiologie

    Praha 11 - Chodov, 148 00

  • Kardio s.r.o.

    Třebíč, 67401

  • Nemocnice Podlesi

    Třinec, 73961

  • Angiocor s.r.o.

    Zlín, 760 01

  • Nemocnice Znojmo

    Znojmo, 669 02

Other trials in Czechia

Spain23 sites

  • Instituto Medico Quirurgico San Rafael S.A. - Cardiologia

    A Coruña, 15006

  • Hospital del Mar

    Barcelona, 08003

  • Ciutat Sanitaria i Universitaria de la Vall d'Hebron

    Barcelona, 08035

  • Hospital Universitari de Bellvitge (HUB)

    Barcelona, 8908

  • Hospital Santa María del Puerto - Medicina Interna

    El Puerto de Santa María, Cádiz, 11500

  • Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión Arterial

    Ferrol, A Coruña, 15405

  • Hospital Universitario Virgen De Las Nieves - Cardiologia

    Granada, 18014

  • Hospital Universitario de Gran Canaria Dr. Negrin - Cardiologia

    Las Palmas de Gran Canaria, Las Palmas, 35010

  • Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De Lleida - Medicina Interna

    Lleida, 25198

  • Hospital Universitario La Zarzuela - Cardiologia

    Madrid, 28023

  • Hospital Ramón y Cajal | Medicina Interna

    Madrid, 28034

  • Hospital Universitario 12 de Octubre

    Madrid, 28041

  • Hospital Universitario Virgen De La Victoria - Cardiologia

    Málaga, Málaga, 29010

  • Hospital Central de Asturias

    Oviedo, Principality of Asturias, 33011

  • Hospital Vega Baja De Orihuela - Medicina Interna

    San Bartolomé, Alicante, 03314

  • Hospital Virgen del Camino - Medicina Interna

    Sanlúcar de Barrameda, Cádiz, 11540

  • Hospital Universitario Virgen de Valme - Medicina Interna

    Seville, 41014

  • Hospital Alta Resolucion de Utrera - Cardiologia

    Utrera, Sevilla, 41710

  • Hospital Clinico Universitario de Valencia (CHUV)

    Valencia, 46010

  • Hospital General Universitario de Valencia

    Valencia, 46014

  • Hospital Universitario Y Politecnico La Fe - Cardiologia

    Valencia, 46026

  • Hospital de Manises - Medicina Interna

    Valencia, 46940

  • Hospital Virgen De Las Montanas - Medicina Interna

    Villamartín, Cádiz, 11650

Other trials in Spain

Italy22 sites

  • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - Cardiologia 1

    Bergamo, Lombardy, 24127

  • Azienda Unita Sanitaria Locale Di Bologna_Ospedale Maggiore Pizzardi - Medicina A

    Bologna, Emilia-Romagna, 40133

  • Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Medicina Interna Cardiovascolare

    Bologna, Emilia-Romagna, 40138

  • Azienda Socio-Sanitaria Territoriale Del Garda

    Brescia, Lombardy, 25085

  • Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia - Cardiologia

    Brescia, Lombardy, 25123

  • Azienda Ospedaliero Universitaria Renato Dulbecco

    Catanzaro, Calabria, 88100

  • Azienda Unita' Sanitaria Locale Toscana Sud Est

    Cortona, Tuscany, 52040

  • Azienda Socio Sanitaria Territoriale Di Cremona

    Cremona, Lombardy, 26100

  • University Hospital Of Ferrara

    Ferrara, Emilia-Romagna, 44124

  • Centro Cardiologico Monzino S.p.A.

    Milan, Lombardy, 20138

  • ASST di Monza

    Monza Brianza, Lombardy, 20832

  • Azienda Ospedaliera Universitaria Federico II Di Napoli - DAI Emergenze Cardiovascolari, Medicina Clinica e Dell'Invecchiamento

    Naples, Campania, 80131

  • A.O.U. Maggiore della Carità

    Novara, Piedmont, 28100

  • IRCCS Fondazione Policlinico San Matteo

    Pavia, Lombardy, 27100

  • Istituti Clinici Scientifici Maugeri S.p.A

    Pavia, Lombardy, 27100

  • A.O. di Perugia_Hospital Santa Maria della Misericordia - S.C. Cardiologia

    Perugia, Umbria, 06129

  • Azienda Unita Sanitaria Locale Di Piacenza

    Piacenza, Emilia-Romagna, 29121

  • Humanitas Mirasole S.p.A. - Cardiologia Clinica e Interventistica

    Rozzano, Lombardy, 20089

  • Azienda Ospedaliera Universitaria Senese

    Siena, Tuscany, 53100

  • ASST Sette Laghi_Ospedale Galmarini - Medicina Generale

    Tradate, Lombardy, 21049

  • Azienda Ospedaliera Universitaria Integrata Verona_Borgo Trento - Cardiologia

    Verona, Veneto, 37126

  • Azienda Socio Sanitaria Territoriale Della Brianza _Ospedale di Vimercate - Medicina Interna

    Vimercate, Lombardy, 20871

Other trials in Italy

Canada21 sites

  • Brampton Clinical Trials

    Brampton, Ontario, L6Z 4N5

  • Cambridge Cardiac Care Centre

    Cambridge, Ontario, N1R 6V6

  • Vizel Cardiac Research

    Cambridge, Ontario, N1R 7R1

  • Dalhousie University - Queen Elizabeth II (QEII) Health Sciences Centre - Halifax Infirmary (HI)

    Halifax, Nova Scotia, B3H 3A7

  • Centre intégré de santé et de services sociaux de Laval, Hôp

    Laval, Quebec, H7M 3L9

  • London Health Sciences Centre (LHSC) - University Hospital

    London, Ontario, N6A 5A5

  • KMH Cardiology Clinics Inc.

    Mississauga, Ontario, L5K 2L3

  • G.A. Research Associates, Ltd.

    Moncton, New Brunswick, E1G 1A7

  • Clinique Sante Cardio MC

    Montreal, Quebec, H1T 3Y7

  • Centre Hospitalier de l'Université de Montréal-CHUM

    Montreal, Quebec, H2X 0C1

  • Montreal General Hospital

    Montreal, Quebec, H4A 3J1

  • Fraser Clinical Trials, Inc.

    New Westminster, British Columbia, V3L 3W4

  • North York Diagnostic and Cardiac Centre

    North York, Ontario, M6B 3H7

  • Oakville Cardiovascular Research

    Oakville, Ontario, L6K 3W7

  • Office of Dr. James Cha, MD

    Oshawa, Ontario, L1J 2K1

  • Kawartha Cardiology Clinical Trials

    Peterborough, Ontario, K9J 0B2

  • Corcare

    Scarborough Village, Ontario, M1B 5N1

  • Medicus MFC Inc.

    Toronto, Ontario, M4P 1E4

  • Mount Sinai Hospital

    Toronto, Ontario, M5G 1X5

  • Women's College Hospital

    Toronto, Ontario, M5S 1B2

  • St. Boniface Hospital

    Winnipeg, Manitoba, R2H 2A6

Other trials in Canada

Ukraine21 sites

  • MNPE "Cherkasy Regional Cardiology Center" - Department of Coronary Heart Disease and Non-Coronary Myocardial Diseases

    Cherkasy, 18009

  • Clinical Emergency Hospital" of Dnipro City Council - Department of Cardiology

    Dnipro, 49006

  • National Institute of Therapy L.T.Maloyi, Department of Chronic Non-Communicable Diseases

    Kharkiv, 61039

  • Regional Dispensary of Radiation Protection of Population - Cardiology Department

    Kharkiv, 61166

  • MNPE "City Clinical Hospital No. 8" of the Kharkiv City Council, Cardiology Department No. 2

    Kharkiv, 61176

  • Municipal Non-Profit Enterprise "Kyiv City Clinical Hospital No. 1" - Department of Cardiology

    Kiev, 02 091

  • Medical Center "Medbud" - Treatment and prophylactic department

    Kyiv, 03037

  • National Scientific Center Institute of Cardiology named M.D. Strazhesko of the NAMSU - Department of Cardiac Arrhythmias

    Kyiv, 03151

  • National Scientific Center Institute of Cardiology named M.D. Strazhesko of the NAMSU - Department of Heart Failure

    Kyiv, 03151

  • National Scientific Center Institute of Cardiology named M.D. Strazhesko of the NAMSU - Department of Hypertension

    Kyiv, 03151

  • LLC "Medical Center "Consilium Medical", Clinical and Consultative Departmen 1

    Kyiv, 04050

  • Railway Clinical Hospital #2

    Kyiv, 3049

  • Lviv Regional Clinical Treatment and Diagnostic Cardiology Center, consulting polyclinic

    Lviv, 79015

  • Poltava Regional Clinical Hospital. M.V. Sklifosovsky, Cardiology Department

    Poltava, 36011

  • Zakarpatsky Oblasnyi Kardiologichnyi Dyspanser, Infarction department

    Uzhhorod, 880000

  • Vinnytsia Regional Clinical Hospital, Clinical Cardiology Department

    Vinnytsia, 21018

  • Vinnytsia City Clinical Hospital #1, Therapeutic Department

    Vinnytsia, 21029

  • Zaporizhia Municipal Clinical Hospital No.10, Cardiology Department

    Zaporizhzhya, 69001

  • Zaporizhzhya City Emergency Care Hospital, Cardiology Department

    Zaporizhzhya, 69005

  • Regional Medical Center for Cardiovascular Diseases-Heart failure department

    Zaporizhzhya, 69005

  • Hospital No. 1 of the Zhytomyr City - consulting and treatment department Scientific and research center

    Zhytomyr, 10002

Other trials in Ukraine

Bulgaria20 sites

  • Ambulatory facility for specialized outpatient medical care

    Burgas, 8000

  • MHAT Haskovo

    Haskovo, 6304

  • MHAT Zdrave

    Pazardzhik, 4400

  • Multiprofile Hospital for Active Treatment Sveti Georgi OOD, Pernik - Department of Cardiology

    Pernik, 2300

  • Medical Center Medconsult Pleven

    Pleven, 5800

  • Medical centre Hipokrat - N EOOD

    Plovdiv, 4000

  • Multiprofile Hospital for Active Treatment Medline | Cardiology Department

    Plovdiv, 4000

  • Multiprofile Hospital for Active Treatment Sveta Karidad | Cardiology Department

    Plovdiv, 4004

  • Multiprofile Hospital for Active Treatment | Shumen - First Department of Internal Medicine

    Shumen, 9700

  • MHAT Hadzhi Dimitar

    Sliven, 8800

  • Second Medical Center Sofia EOOD

    Sofia, 1202

  • Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology Department

    Sofia, 1233

  • NMTH Tzar Boris III

    Sofia, 1233

  • Multiprofile Hospital for Active Treatment 'National Cardiology Hospital' EAD, Sofia

    Sofia, 1309

  • Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases Department

    Sofia, 1404

  • Medical Center Hera

    Sofia, 1510

  • UMHAT Tsaritsa Joanna-ISUL EAD Sofia

    Sofia, 1527

  • MHAT Trakia

    Stara Zagora, 6000

  • Multiprofile Hospital for Active Treatment Dr. Stefan Cherkezov | Cardiology Department

    Veliko Tarnovo, 5000

  • Multiprofile Hospital for Active Treatment Sveti Panteleymon Yambol | Cardiology Department

    Yambol, 8600

Other trials in Bulgaria

Argentina19 sites

  • Instituto Cardiovascular de Buenos Aires | Buenos Aires, Argentina

    Buenos Aires, Buenos Aires F.D., C1428ART

  • Hospital Militar Central "CIR. MY. C. Argerich"

    Buenos Aires, Ciudad Auton. de Buenos Aires, 1426

  • Centro de Especialidades Medicas (CEMEDIC)

    Buenos Aires, Ciudad Auton. de Buenos Aires, C1440CFD

  • Investigaciones Medicas IMOBA S.R.L.

    Buenos Aires, C1056ABH

  • CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina

    CABA, Ciudad Auton. de Buenos Aires, C1018DES

  • Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, Argentina

    Ciudad Autónoma de Buenos Aire, Buenos Aires, C1056ABI

  • Clínica Privada del Prado

    Córdoba, 5000

  • Instituto Médico DAMIC- Fundación Rusculleda

    Córdoba, 5003

  • Clínica Coronel Suarez

    Coronel Suárez, Buenos Aires, B7540GHD

  • Instituto de Cardiologia de Corrientes Juana F. Cabral | Corrientes, Argentina

    Corrientes, 3400

  • Hospital Italiano de La Plata | Clinical Research Department

    La Plata, Buenos Aires, B1900

  • Centro de Investigaciones Medicas Lanus | Buenos Aires, Argentina

    Lanus, Buenos Aires, B1824

  • Sanatorio Modelo Quilmes

    Quilmes, Buenos Aires, 1878

  • Grupo Orono | Instituto Cardiovascular de Rosario - Insuficiencia Cardiaca y Trasplante Department

    Rosario, Santa Fe Province, 2000

  • Consultorios Integrados Rosario | Instituto Medico de la Fundacion de Estudios Clinicos

    Rosario, Santa Fe Province, S2000DEJ

  • Corporación Médica de General San Martín

    San Martín, Buenos Aires, 1650

  • Instituto de Cardiologia | Tucuman, AR

    San Miguel de Tucumán, Tucumán Province, 4000

  • Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina

    Santa Fe, S3000FWO

  • Instituto De Investigaciones Clinicas Zarate | Zarate, Argentina

    Zárate, Buenos Aires, B2800DGH

Other trials in Argentina

Brazil19 sites

  • Centro de Pesquisa Clinica do Coração | Aracaju, Brasil

    Aracaju, Sergipe, 49055-530

  • Hospital Felício Rocho

    Belo Horizonte, São Paulo, 30110-130

  • MK Consultoria Médico Científica Ltda/Angiocor Blumenau

    Blumenau, Santa Catarina, 89020-430

  • Hospital do Coração do Brasil

    Brasília, Federal District, 70390-700

  • Campinas Clinical Research Institute (IPECC) | Campinas, Brazil

    Campinas, São Paulo, 13060-080

  • Fundação Universidade de Caxias do Sul

    Caxias do Sul, Rio Grande do Sul, 95070-560

  • Quanta Diagnostico Por Imagem | Research and Innovation Department

    Curitiba, Paraná, 80045-170

  • Hospital das Clinicas da Universidade Federal de Goias | Centro de Pesquisa em Cardiologia

    Goiânia, Goiás, 74605-020

  • Instituto do Coração de Marilia | Marilia, Brasil

    Marília, São Paulo, 17515-000

  • Eurolatino Pesquisas Medicas | Uberlandia, MG

    Minas Gerais, 38400-368

  • Sociedade Hospitalar Angelina Caron | Departamento de Ensino e Pesquisa

    Paraná, Paraná, 83430-000

  • Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center

    Porto Alegre, Rio Grande do Sul, 90035-903

  • Hospital Mae de Deus

    Porto Alegre, Rio Grande do Sul, 90850-170

  • FZ Pesquisa e Servicos em Cardiologia | Porto Alegre, Brazil

    Porto Alegre, Rio Grande do Sul, 91350-280

  • Centro Avançado de Pesquisa para Diagnóstico - CAPED

    Ribeirão Preto, São Paulo, 14026-020

  • Santa Casa de Misericórdia da Bahia

    Salvador, Estado de Bahia, 50040-410

  • Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas

    São Paulo, São Paulo, 13034-685

  • IMC - Instituto de Moléstias Cardiovasculares Tatui

    Tatuí, São Paulo, 18270-170

  • Santa Casa de Misericórdia de Votuporanga

    Votuporanga, São Paulo, 15500-003

Other trials in Brazil

Colombia19 sites

  • Cardiomet Cequin Sas

    Armenia, Quindío Department, 630004

  • Clínica de la Costa SAS

    Baranquilla, Atlántico, 080020

  • Corazón IPS S.A.S.

    Barranquilla, Atlántico, 080020

  • IPS Centro Cientifico Asistencial S.A.S

    Barranquilla, Atlántico, 080020

  • Fundacio del Caribe para la Investigacio Bio-Medica (BIOS)

    Barranquilla, 080001

  • Caja de Compensación Familiar CAFAM

    Bogotá, Bogota D.C., 111061

  • Hospital Universitario Mayor-MÉDERI

    Bogotá, Bogota D.C., 111411

  • Fundación Cardioinfantil

    Bogotá, 110131

  • Hospital Universitario de San Ignacio

    Bogotá, 110231

  • Hospital Universitario Clínica San Rafael

    Bogotá, 110621

  • Instituto del Corazón de Bucaramanga

    Bucaramanga, Santander Department, 680002

  • Clínica Imbanaco S.A.S

    Cali, Valle del Cauca Department, 760042

  • Mediservis del Tolima IPS S.A.S

    Ibague, Tolima Department, 730008

  • Hospital Alma Mater de Antioquia

    Medellín, Antioquia, 050010

  • Hospital General de Medellin

    Medellín, Antioquia, 050015

  • Rodrigo Botero S.A.S

    Medellín, Antioquia, 050021

  • Hospital San Vicente Fundación

    Medellín, 050010

  • Clinica Cardio VID

    Medellín, 050034

  • Sociedad Médica Rionegro SOMER S.A.

    Rionegro, Antioquia, 054040

Other trials in Colombia

Slovakia19 sites

  • Stredoslovensky ustav srdcovych a cievnych chorob, a.s.

    Banská Bystrica, 974 01

  • ALIAN s.r.o.

    Bardejov, 085 01

  • Nemocnica svateho Michala, a.s.

    Bratislava, 81108

  • Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto

    Bratislava, 813 69

  • Narodny ustav srdcovych a cievnych chorob, a.s

    Bratislava, 833 48

  • Centrum interv. neuroradiologie a endovaskularnej liecby

    Bratislava, 84103

  • Kardiosanus | Bratislava, Slovakia

    Bratislava, 84107

  • Nemocnica s poliklinikou Brezno, n.o.

    Brezno, 977 01

  • Dolnooravska nemocnica s poliklinikou L. Nadasi Jegeho

    Dolný Kubín, 026 14

  • JG-COR s.r.o.

    Košice, 040 01

  • Medical Group Kosice s.r.o. | Kosice, Slovakia

    Košice, 04001

  • KARDIO-ANGIO s.r.o.

    Levice, 93401

  • KardioMed s.r.o.

    Lučenec, 984 01

  • MEDI M&M, s.r.o.

    Moldava nad Bodvou, 045 01

  • Kardiocentrum Nitra | Cardiology Clinic - Outpatient Department

    Nitra, 949 01

  • KARDIOMED NZ s.r.o.

    Nové Zámky, 940 01

  • MEDISPOL s.r.o.

    Prešov, 08001

  • COR, s.r.o

    Šahy, 936 01

  • Medivasa s.r.o.

    Žilina, 1001

Other trials in Slovakia

Hungary18 sites

  • Cardiomobile Egeszsegugyi Szolgaltato Kft.

    Balatonfüred, 8230

  • Budai Irgalmasrendi Korhaz

    Budapest, 1023

  • Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet

    Budapest, 1024

  • University of Semmelweis/ Semmelweis Egyetem

    Budapest, 1083

  • Eszak-Pesti Centrumkorhaz-Honvedkorhaz

    Budapest, 1134

  • Budapesti Uzsoki Utcai Kórház

    Budapest, 1145

  • Bugat Pal Korhaz

    Gyöngyös, 3200

  • Pharma4Trial Kft.

    Gyöngyös, 3200

  • Csongrad-Csanad Varmegyei Egeszsegugyi Ellato Kozpont Hodmezovasarhelyi Tagintezmeny

    Hódmezővásárhely, 6800

  • Borsod-Abauj-Zemplen Varmegyei Korhaz es Egyetemi Oktatokorhaz

    Miskolc, 3526

  • Nagykanizsai Kanizsai Dorottya Korhaz

    Nagykanizsa, 8800

  • Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.

    Nyíregyháza, 4400

  • Coromed Smo Kft

    Pécs, 7623

  • Da Vinci Maganklinika

    Pécs, 7635

  • SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont

    Szeged, 6720

  • Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz - II. Belgyogyaszat

    Székesfehérvár, 8000

  • Tolna Varmegyei Balassa Janos Korhaz

    Szekszárd, 7100

  • Csongrad-Csanad Megyei Dr. Bugyi Istvan Korhaz

    Szentes, 6600

Other trials in Hungary

Poland15 sites

  • KLIMED Marek Klimkiewicz

    Bialystok, 15-704

  • MICS Centrum Medyczne Bydgoszcz

    Bydgoszcz, 85-065

  • Uniwersyteckie Centrum Medycyny Morskiej i Tropikalnej

    Gdynia, 81-519

  • Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. sw. Jana Pawla II

    Grodzisk Mazowiecki, 05 825

  • CLINICAL MEDICAL RESEARCH Sp. z o. o.

    Katowice, 40-156

  • Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i Naczyn

    Krakow, 31-271

  • IMEDICA Centrum Medyczne

    Lublin, 20-068

  • NZOZ "Twoja Przychodnia" Sp. z o.o.

    Lublin, 20-857

  • Zechowicz Medeusz-Plus Lekarska Spolka Partnerska

    Olsztyn, 10-010

  • Oswiecimskie Centrum Badan Klinicznych Medicome Sp. z o.o.

    Oświęcim, 32-600

  • Uniwersytecki Szpital Kliniczny w Poznaniu

    Poznan, 61-848

  • Szpital Specjalistyczny SPZOZ

    Puławy, 24-100

  • NZOZ Pro-Cordis Sopockie Centrum Badan Kardiologicznych

    Sopot, 81-717

  • Twoja Przychodnia - Szczecinskie Centrum Medyczne

    Szczecin, 71-500

  • Gessek Jacek Prywatny Gabinet Lekarski

    Torun, 87-100

Other trials in Poland

Romania15 sites

  • Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare

    Baia Mare, 430031

  • Emergency County Hospital, Braila

    Brăila, 810318

  • S.C Thera Card S.R.L

    Brasov, 500102

  • Emergency Institute for Cardiovascular Diseases

    Bucharest, 22322

  • Spitalul Universitar de Urgenta Bucuresti

    Bucharest, 50098

  • Spitalul Clinic de Urgenta "Sf. Pantelimon"

    Bucharest, TBC

  • Spitalul Clinic Judetean De Urgenta Craiova

    Craiova Dolj, 200642

  • Sf. Ap. Andrei Emergency Clinical County Hospital Galati

    Galati, 800578

  • S.C. CARDIOMED S.R.L. Iasi

    Iași, 700732

  • S.C. Sal Med SRL

    Piteşti, TBC

  • CMI. Dr. Podoleanu Cristian

    Târgu Mureş, Mureș County, TBC

  • S.C. Cardio Med S.R.L.

    Târgu Mureş, 540124

  • Spitalul Clinic Municipal de Urgenta "Timisoara"

    Timișoara, Timiș County, 300040

  • Municipal Clinical Emergency Hospital of Timisoara

    Timișoara, Timiș County, 300254

  • Institutul De Boli Cardiovasculare Timisoara

    Timișoara, 300310

Other trials in Romania

Israel14 sites

  • Assuta Ashdod Public Hospital (R.A)

    Ashdod, 7747629

  • Barzilai Ashkelon University Medical Center | Cardiology Department

    Ashkelon, 7830604

  • Rambam Health Corporation

    Haifa, 3109601

  • Bnai Zion Medical Center | Cardiology Department

    Haifa, 3339419

  • Lady Davis Carmel Medical Center

    Haifa, 3436212

  • Hadassah Hebrew University Hospital Ein Kerem

    Jerusalem, 9112001

  • Meir Medical Center

    Kfar Saba, 4428164

  • Health Corporation of Galilee Medical Center

    Nahariya, 2210001

  • Chaim Sheba Medical Center

    Ramat Gan, 5262000

  • Kaplan Medical Center

    Rehovot, 7610001

  • Health Corporation of the Ziv Medical Center (R.A.)

    Safed, 1311001

  • Tel-Aviv Sourasky Medical Center

    Tel Aviv, 6423906

  • Poria Medical Center | Cardiovascular Department

    Tiberias, 1528001

  • Shamir Medical Center (Assaf Harofeh)

    Ẕerifin, 7030000

Other trials in Israel

United Kingdom14 sites

  • Wansbeck General Hospital

    Ashington, Northumberland, NE63 9JJ

  • North Hampshire Hospital

    Basingstoke, Hampshire, RG24 9NA

  • Blackpool Victoria Hospital

    Blackpool, Lancashire, FY3 8NR

  • Royal Bournemouth General Hospital

    Bournemouth, Dorset, BH7 7DW

  • University Hospitals Sussex NHS Foundation Trust | St Richard's Hospital - Cardiology services

    Chichester, West Sussex, PO19 6SE

  • Hull University Teaching Hospitals NHS Trust | Castle Hill Hospital - Cardiology

    Cottingham, HU16 5JQ

  • Dudley Group NHS Foundation Trust ¦Russells Hall Hopsital - Oncology

    Dudley, West Midlands, DY1 2HQ

  • Queen Elizabeth University Hospital

    Glasgow, Glasgow City, G51 4TF

  • NHS Greater Glasgow and Clyde | Glasgow Royal Infirmary |Glasgow Research Facility - Cardiology

    Glasgow, G31 2ER

  • University Hospitals Leicester

    Leicester, Leicestershire, LE3 9QP

  • Manchester Royal Infirmary

    Manchester, M13 9WL

  • Poole Hospital NHS Trust

    Poole, Dorset, BH15 2JB

  • Lister Hospital

    Stevenage, Hertfordshire, SG1 4AB

  • Great Western Hospital

    Swindon, SN3 6BB

Other trials in United Kingdom

Netherlands13 sites

  • Ziekenhuis Groep Twente

    Almelo, 7609 PP

  • Deventer Ziekenhuis

    Deventer, 7416 SE

  • Slingeland Ziekenhuis

    Doetinchem, 7009 BL

  • Ziekenhuis Gelderse Vallei

    Ede, 6716 RP

  • Catharina Ziekenhuis

    Eindhoven, North Brabant, 5623 EJ

  • Universitair Medisch Centrum Groningen

    Groningen, 9713 GZ

  • Ziekenhuis St. Jansdal

    Harderwijk, 3844 DG

  • Tergooiziekenhuizen-Blaricum

    Hilversum, 1212 VG

  • Maastricht UMC

    Maastricht, 6229 HX

  • Isala Meppel

    Meppel, 7943 KA

  • Antonius Ziekenhuis Sneek

    Sneek, 8601 ZR

  • ETZ TweeSteden Ziekenhuis (vh Maria Ziekenhuis)

    Tilburg, 5042 AD

  • Maxima Medisch Centrum, locatie Veldhoven

    Veldhoven, 5504 DB

Other trials in Netherlands

Turkey (Türkiye)13 sites

  • Afyonkarahisar Saglik Bilimleri Universitesi

    Afyonkarahisar, 3218

  • Saglik Bilimleri Universitesi Antalya EA Hastanesi

    Antalya, 7100

  • Trakya Univ. Tip Fak.

    Edirne, 22030

  • Eskisehir Osmangazi Universitesi Tip Fakultesi

    Eskişehir, 26480

  • Istanbul Universitesi Cerrahpasa-Cerrahpasa Tip Fakultesi

    Istanbul, 34098

  • Istanbul Universitesi Kardiyoloji Enstitusu

    Istanbul, 34304

  • Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H.

    Istanbul, TBC

  • Dokuz Eylul Universitesi Tip Fakultesi

    Izmir, 35340

  • Erciyes Universitesi Tip Fakultesi

    Kayseri, 38039

  • Kocaeli Universitesi Tip Fakultesi

    Kocaeli, 41380

  • Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi

    Konya, 42080

  • Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve Arasti

    Kütahya, 43040

  • Mersin Universitesi Tip Fakultesi

    Mersin, 33079

Other trials in Turkey (Türkiye)

Greece12 sites

  • University General Hospital of Alexandroupoli

    Alexandroupoli, 68100

  • General Hosp of Athens "Korgialenio-Benakeio" RCH

    Ampelokipi - Athens, 11526

  • HIPPOKRATION General Hospital of Athens

    Athens, 115 27

  • G. GENNIMATAS General State Hospital of Athens

    Athens, 11527

  • ALEXANDRA General Hospital of Athens

    Athens, 11528

  • University General Hospital of Athens "ATTIKON"

    Chaïdári, 12462

  • University General Hospital of Heraklion - Department of Paediatrics

    Heraklion, 711 10

  • KAT General Hospital of Athens

    Kifissia, Attica, 14561

  • University General Hospital of Larissa

    Larissa, 41110

  • Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA

    Nea Ionia, 14233

  • University General Hospital of Patras

    Pátrai, 26504

  • Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit'

    Thessaloniki, 54642

Other trials in Greece

Portugal12 sites

  • Hospital Prof. Dr. Fernando Fonseca

    Amadora, 2720-276

  • BlueClinical | Centro Hospitalar Baixo Vouga - Unidade Aveiro - Gabinete de Ensaios Clinicos

    Aveiro, 3810-501

  • Unidade Local de Saúde de Coimbra, E.P.E. - Cardiology Department - Research Unit

    Coimbra, 3004-561

  • Centro Hospitalar Universitario Cova de Beira | Clinical Research Department

    Covilha, Castelo Branco District, 6200-251

  • ULSG - Unidade Local de Saude da Guarda

    Guarda, 6300-659

  • Hospital da Senhora da Oliveira | Clinical Research Department

    Guimaraes, Braga, Braga District, 4835-044

  • Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center

    Leiria, 2410-197

  • Unidade Local De Saúde De Lisboa Ocidental E.P.E.

    Lisbon, 1449-005

  • Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica

    Lisbon, 1500-650

  • Hospital Pedro Hispano | Clinical Research Center

    Matosinhos Municipality, Porto District, 4464-513

  • Centro Hospitalar Universitario do Porto

    Porto, 4099-001

  • Luz Saude | Hospital da Luz Setubal - Clinical Research Department

    Setúbal, Setúbal District, 2900-722

Other trials in Portugal

Australia10 sites

  • The Wesley Hospital

    Auchenflower, Queensland, 4066

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042

  • Advara HeartCare Ringwood

    Bundoora, Victoria, 3083

  • Royal Prince Alfred Hospital

    Camperdown, New South Wales, 2050

  • The Prince Charles Hospital

    Chermside, Queensland, 4032

  • Gosford Hospital

    Gosford, New South Wales, 2250

  • Royal Brisbane and Women's Hospital

    Herston, Queensland, 4029

  • Advara HeartCare Leabrook

    Leabrook, South Australia, 5068

  • John Hunter Hospital

    New Lambton Heights, New South Wales, 2305

  • Gold Coast University Hospital

    Southport, Queensland, 4215

Other trials in Australia

South Korea10 sites

  • Hallym University Sacred Heart Hospital

    Anyang-si, Gyeonggido, 14068

  • Dong-A University Hospital

    Busan, 49201

  • Pusan National University Hospital

    Busan, 49241

  • Chungbuk National University Hospital

    Cheongju-si, North Chungcheong, 28644

  • Chung Nam National University Hospital

    Daejeon, 35015

  • Chonnam National University Hospital

    Gwangju, 501-757

  • Bundang Cha Hospital

    Seongnam-si, Gyeonggido, 13496

  • Severance Hospital, Yonsei University Health System

    Seoul, Seoul Teugbyeolsi, 03722

  • Seoul National University Hospital

    Seoul, Seoul Teugbyeolsi, 3080

  • Yonsei University Wonju Christian Hospital

    Wŏnju, Gang''weondo, 26426

Other trials in South Korea

Austria9 sites

  • Krankenhaus St. Josef Braunau | Innere Medizin I

    Braunau am Inn, Upper Austria, 5280

  • Landeskrankenhaus Feldkirch

    Feldkirch, Vorarlberg, 6807

  • Medizinische Universität Graz

    Graz, Styria, 8036

  • Klinikum Klagenfurt am Wörthersee

    Klagenfurt, Carinthia, 9020

  • Uniklinikum Salzburg - Landeskrankenhaus

    Salzburg, 5020

  • Universitätsklinikum St. Pölten

    Sankt Pölten, Lower Austria, 3100

  • Universitätsklinikum AKH Wien

    Vienna, 1090

  • Imed19-privat

    Vienna, 1190

  • Klinik Floridsdorf - Krankenhaus Nord

    Vienna, 1210

Other trials in Austria

Denmark9 sites

  • Aarhus Universitetshospital - Børn og Unge

    Århus N, 8200

  • Sydvestjysk Sygehus Esbjerg | Kardiologisk Forskningsenhed

    Esbjerg, 6700

  • Capital Region | Gentofte Hospital - Cardiology Research

    Hellerup, 2900

  • Capital Region | Herlev Hospital - Heart Disease Department

    Herlev, 2730

  • Region Midtjylland | Regionshospitalet Godstrup - Clinic for Heart Research

    Herning, 7400

  • Region Sjælland | Holbaek Sygehus - Cardiology department

    Holbæk, 4300

  • Hvidovre Hospital - Hjertesygdomme

    Hvidovre, 2650

  • Regionshospitalet Randers - Medicinsk afdeling

    Randers, 8930

  • Odense University Hospital | Svendborg Hospital - Cardiovascular Research Unit

    Svendborg, 5700

Other trials in Denmark

Mexico9 sites

  • Hospital General de Acapulco

    Acapulco de Juárez, Guerrero, 39910

  • Hospital Cardiologica Aguascalientes

    Aguascalientes, 20230

  • Hospital de Jesús

    Alcaldía Cuauhtemoc, Mexico City, 6090

  • Fundación de Atencion e Investigacion Medica Lindavista SC

    Alcaldia Gustavo A. Madero, Mexico City, 7300

  • Centro de Investigacion y Atencion Integral Durango S.C.

    Durango, 34080

  • Consultorio de Medicina Especializada del Sector Privado

    Guadalajara, Jalisco, 44657

  • Centro de Estudios Clinicos de Queretaro S. C. (CECLIQ)

    Querétaro City, Querétaro, 76000

  • Centro de Investigación Médica Dr. Alberto Bazzoni SA de CV

    Torreón, Coahuila, 27000

  • Hospital Ángeles de Xalapa

    Xalapa, Veracruz, 91193

Other trials in Mexico

Taiwan8 sites

  • Changhua Christian Hospital

    Changhua, 50006

  • Mackay Memorial Hospital - Hsinchu Branch

    Hsinchu, 300

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, Kaohsiung, 807377

  • Taichung Veterans General Hospital

    Taichung, 40705

  • National Taiwan University Hospital

    Taipei, 100

  • Taipei Medical University Hospital

    Taipei, 100

  • Taipei Veterans General Hospital

    Taipei, 11217

  • Chang Gung Memorial Hospital at Linkou

    Taoyuan, 33305

Other trials in Taiwan

Germany7 sites

  • Städt. Kliniken Bielefeld gGmbH

    Bielefeld, North Rhine-Westphalia, 33604

  • Universitätsklinikum Hamburg Eppendorf (UKE)

    Hamburg, 20246

  • Medizinische Hochschule Hannover (MHH)

    Hanover, Lower Saxony, 30625

  • Sana-Klinikum Remscheid GmbH

    Remscheid, North Rhine-Westphalia, 42859

  • Herzklinik Ulm GbR

    Ulm, Baden-Wurttemberg, 89077

  • Forschungszentrum Ruhr | KliFoCenter GmbH

    Witten, North Rhine-Westphalia, 58455

  • Klinikum der Universität Würzburg

    Würzburg, Bavaria, 97080

Other trials in Germany

Latvia7 sites

  • Daugavpils Regional Hospital

    Daugavpils, LV-5417

  • Jelgava Outpatient Clinic

    Jelgava, LV-3001

  • Liepaja Regional Hospital

    Liepāja, LV-3414

  • 1st Riga Clinical Hospital

    Riga, LV-1001

  • P. Stradins Clinical University Hospital

    Riga, LV-1002

  • GK Neiroklinika

    Riga, LV-1024

  • Gita Rancane - cardiology private practice

    Ventspils, LV-3601

Other trials in Latvia

Lithuania7 sites

  • UAB "Klinikiniai sprendimai" Alytus

    Alytus, LT-63200

  • LUHS Kauno Hospital (Laisves ave.)

    Kaunas, LT-44320

  • LUHS Kauno Hospital (Josvainiu str.)

    Kaunas, LT-47144

  • Saules family medicine center

    Kaunas, LT-49449

  • Klaipedos Jurininku Ligonine

    Klaipėda, LT-92288

  • Siauliai Republican hospital

    Šiauliai, 76231

  • Vilnius University Hospital Santaros Klinikos

    Vilnius, LT-08661

Other trials in Lithuania

Malaysia7 sites

  • Gleneagles Penang Medical Center

    George Town, 10050

  • Institute Jantung Negara

    Kuala Lumpur, 50400

  • University Malaya Medical Centre

    Kuala Lumpur, 59100

  • Hospital Sultan Idris Shah Serdang (Hospital Serdang)

    Kuala Selangor, 43000

  • Hospital Raja Permaisuri Bainun

    Perak, 30450

  • Hospital Pulau Pinang

    Pulau Pinang, 10450

  • Sarawak Heart Centre

    Sarawak, 94300

Other trials in Malaysia

New Zealand7 sites

  • University of Auckland

    Auckland, 1023

  • Christchurch Heart Institute

    Christchurch, 8140

  • Dunedin Hospital

    Dunedin, 9016

  • P3 Research Ltd Tauranga

    Hawkes Bay, 4130

  • Hutt Hospital

    Lower Hutt, 5010

  • Nelson Hospital

    Nelson, 7042

  • P3 Research

    Tauranga, 3110

Other trials in New Zealand

India5 sites

  • KEM hospital

    Berlin, Maharashtra, 10365

  • The Madras Medical Mission (MMM)

    Chennai, Tamil Nadu, 600037

  • Max Super Speciality Hospital, Saket

    New Delhi, National Capital Territory of Delhi, 110017

  • Safdarjung Hospital

    New Delhi, National Capital Territory of Delhi, 110029

  • Deenanath Mangeshkar Hospital

    Pune, Maharashtra, 411004

Other trials in India

Hong Kong4 sites

  • Prince of Wales Hospital

    Hong Kong, N.T, MISSING

  • Princess Margaret Hospital

    Hong Kong, MISSING

  • Queen Mary Hospital

    Hong Kong, MISSING

  • Queen Elizabeth Hospital Hong Kong

    Hong Kong

Other trials in Hong Kong

Finland3 sites

  • HUS Jorvin sairaala

    Espoo, 2740

  • Tampereen yliopistollinen sairaala

    Tampere, 33520

  • Turun yliopistollinen keskussairaala

    Turku, 20520

Other trials in Finland

About this study

Official title: A Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Finerenone on Morbidity and Mortality in Participants With Heart Failure (NYHA II-IV) and Left Ventricular Ejection Fraction ≥ 40% (LVEF ≥ 40%)

The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits for HF(generally meaning a hospital stay or urgent presentation to a healthcare unit due to worsening symptoms of heart failure) in patients suffering from HF with an ejection fraction greater than or equal to 40%. Researchers will also collect information on how much the heart disease has impact on patient's lives, change of kidney function, and how well finerenone treatment is tolerated. The study plans to enroll 6000 male and female patients of the age of 40 years and above suffering from heart failure with ejection fraction greater than or equal to 40%. Participants will take the study product as oral tablet with a dose between 0 (Placebo) 40 mg once daily. Study duration will be up to 43 months.

Conditions
Heart Failure
Being tested
Finerenone (BAY94-8862), Placebo
Keywords
Heart Failure with Preserved Ejection Fraction,, Mineralocorticoid receptor antagonist (MRA)
Medical subject headings
Heart Failure

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Finerenone (BAY94-8862)Drug

    For participants with an eGFR ≤60 mL/min/1.73 m^2: Starting dose is 10 mg OD and maximum dose 20 mg OD.

    For participants with an eGFR >60 mL/min/1.73 m^2: Starting dose is 20 mg OD and maximum dose 40 mg OD. Finerenone is administered orally as immediate release tablets.

  • PlaceboOther

    Placebo tablets matching BAY94-8862 are administered orally.

Study groups in NCT04435626
Study groupRoleWhat they receive
Arm 1_BAY94-8862ExperimentalAdult patients receive BAY94-8862
Receives: Drug: Finerenone (BAY94-8862)
Arm 2_PlaceboPlacebo comparatorAdult patients receive placebo
Receives: Other: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Occurrence of the Composite Endpoint of Cardiovascular Death and Total (First and Recurrent) Heart Failure Events

    Number of composite endpoint events of cardiovascular death and total (first and recurrent) heart failure (HF) events (hospitalization for heart failure or urgent HF visit) in HF patients.

    Measured: From randomization up until the end of study, with an average study duration of 32 months

  2. Occurrence of the Composite Endpoint of Cardiovascular Death and Total (First and Recurrent) Heart Failure Events

    Number of participants with composite endpoint events of cardiovascular death and total (first and recurrent) heart failure (HF) events (hospitalization for heart failure or urgent HF visit) in HF patients.

    Measured: From randomization up until the end of study, with an average study duration of 32 months

Secondary outcomes (6)

  1. Occurrence of Total (First and Recurrent) Heart Failure Events

    Number of total (first and recurrent) heart failure events.

    Measured: From randomization up until the end of study, with an average study duration of 32 months

  2. Occurrence of Total (First and Recurrent) Heart Failure Events

    Number of participants with total (first and recurrent) heart failure events.

    Measured: From randomization up until the end of study, with an average study duration of 32 months

  3. Change From Baseline in Total Symptom Score (TSS) of the Kansas City Cardiomyopathy Questionnaire (KCCQ)

    The Kansas City Cardiomyopathy Questionnaire Total Symptom Score (KCCQ-TSS) is ranged from 0 to 100. A higher score (closer to 100) reflects fewer symptoms, indicating better heart failure symptom status.

    For the change from baseline the combined and averaged result across the entire time frame is reported.

    Measured: From baseline to Month 6, 9 and 12

  4. Proportion of Participants Who Showed Improvement in NHYA Class

    The New York Heart Association (NYHA) Functional Classification is a simple scale that classifies patients with heart failure based on the severity of their symptoms and how those symptoms affect their physical activity, which ranges from Class I to Class IV, a lower class number is indicative of a better condition. A patient was considered as having improved in NYHA class, if the NYHA class at Month 12 is at least one category improved compared to the baseline visit.

    Measured: from baseline to Month 12

  5. First Occurrence of Renal Composite Events

    Number of participants with renal composite events encompassing the components sustained decrease in eGFR ≥50% relative to baseline over at least 4 weeks, sustained eGFR decline to <15 mL/min/1.73 m2 over at least 4 weeks, initiation of chronic dialysis and renal transplantation.

    Measured: From randomization up to end of study visit, with an average study duration of 32 months

  6. Occurence of All-cause Mortality (Full Analysis Set)

    Number of participants with death due to any cause were reported as descriptive result. Number of participants with outcome death reported here includes deaths occurred after randomization until the end of the study visit. Deaths after end of study visit are not included in this table.

    Measured: From randomization until end of study, with an average of 32 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted17 Jun 2020
  2. Study start14 Sep 2020
  3. Primary completion15 May 2024
  4. Study completion14 Jun 2024

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
6,016 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT04435626
Sponsor's protocol ID
20103
Other IDs
2020-000306-29
Acronym
FINEARTS-HF
Status last verified
Aug 2025
First submitted
15 Jun 2020
Last updated
26 Aug 2025
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
No: Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014. Interested researchers can use www.vivli.org to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the member section of the portal.

Publications

  • Bhatt AS, Chatur S, Claggett BL, Lay-Flurrie J, Viswanathan P, Vardeny O, Kosiborod MN, Sharma K, Solomon SD, Vaduganathan M. Gamified Behavioral Science Intervention to Enhance Trial Enrollment: An Embedded Study Within the FINEARTS-HF Trial. JACC Heart Fail. 2024 Nov;12(11):1939-1941. doi: 10.1016/j.jchf.2024.05.002. Epub 2024 May 11. No abstract available.

    PubMed 38944793

  • Jhund PS, Talebi A, Henderson AD, Claggett BL, Vaduganathan M, Desai AS, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Solomon SD, McMurray JJV. Mineralocorticoid receptor antagonists in heart failure: an individual patient level meta-analysis. Lancet. 2024 Sep 21;404(10458):1119-1131. doi: 10.1016/S0140-6736(24)01733-1. Epub 2024 Sep 1.

    PubMed 39232490

  • Kondo T, Henderson AD, Docherty KF, Jhund PS, Vaduganathan M, Solomon SD, McMurray JJV. Why Have We Not Been Able to Demonstrate Reduced Mortality in Patients With HFmrEF/HFpEF? J Am Coll Cardiol. 2024 Nov 26;84(22):2233-2240. doi: 10.1016/j.jacc.2024.08.033. Epub 2024 Sep 1.

    PubMed 39217560

  • Ostrominski JW, Aggarwal R, Claggett BL, Kulac IJ, Desai AS, Jhund PS, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Lay-Flurrie J, Viswanathan P, McMurray JJV, Solomon SD, Vaduganathan M. Generalizability of the Spectrum of Kidney Risk in the FINEARTS-HF Trial to U.S. Adults With Heart Failure. J Card Fail. 2024 Sep;30(9):1170-1174. doi: 10.1016/j.cardfail.2024.04.015. Epub 2024 May 11. No abstract available.

    PubMed 38740173

  • Ostrominski JW, Claggett BL, Miao ZM, Mc Causland FR, Anand IS, Desai AS, Jhund PS, Lam CSP, Pfeffer MA, Pitt B, Zannad F, Zile MR, Bomfim Wirtz A, Lay-Flurrie J, Viswanathan P, McMurray JJV, Solomon SD, Vaduganathan M. Cardiovascular-Kidney-Metabolic Overlap in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Trial-Level Analysis. J Am Coll Cardiol. 2024 Jul 9;84(2):223-228. doi: 10.1016/j.jacc.2024.05.005. Epub 2024 May 12. No abstract available.

    PubMed 38744407

  • Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Henderson AD, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Abidin IZ, Alcocer-Gamba MA, Atherton JJ, Bauersachs J, Chang-Sheng M, Chiang CE, Chioncel O, Chopra V, Comin-Colet J, Filippatos G, Fonseca C, Gajos G, Goland S, Goncalvesova E, Kang S, Katova T, Kosiborod MN, Latkovskis G, Lee AP, Linssen GCM, Llamas-Esperon G, Mareev V, Martinez FA, Melenovsky V, Merkely B, Nodari S, Petrie MC, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, Sharma K, Troughton R, Udell JA, Ukkonen H, Vardeny O, Verma S, von Lewinski D, Voronkov L, Yilmaz MB, Zieroth S, Lay-Flurrie J, van Gameren I, Amarante F, Kolkhof P, Viswanathan P; FINEARTS-HF Committees and Investigators. Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2024 Oct 24;391(16):1475-1485. doi: 10.1056/NEJMoa2407107. Epub 2024 Sep 1.

    PubMed 39225278

  • Solomon SD, Ostrominski JW, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Abidin IZ, Alcocer-Gamba MA, Atherton JJ, Bauersachs J, Ma CS, Chiang CE, Chioncel O, Chopra V, Comin-Colet J, Filippatos G, Fonseca C, Gajos G, Goland S, Goncalvesova E, Kang SM, Katova T, Kosiborod MN, Latkovskis G, Lee AP, Linssen GCM, Llamas-Esperon G, Mareev V, Martinez FA, Melenovsky V, Merkely B, Nodari S, Petrie MC, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, Sharma K, Troughton R, Udell JA, Ukkonen H, Vardeny O, Verma S, von Lewinski D, Voronkov LG, Yilmaz MB, Zieroth S, Lay-Flurrie J, van Gameren I, Amarante F, Viswanathan P, McMurray JJV. Baseline characteristics of patients with heart failure with mildly reduced or preserved ejection fraction: The FINEARTS-HF trial. Eur J Heart Fail. 2024 Jun;26(6):1334-1346. doi: 10.1002/ejhf.3266. Epub 2024 May 11.

    PubMed 38733212

  • Vaduganathan M, Claggett BL, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Desai AS, Jhund PS, Viswanathan P, Bomfim Wirtz A, Schloemer P, Lay-Flurrie J, McMurray JJV, Solomon SD. Finerenone in patients with heart failure with mildly reduced or preserved ejection fraction: Rationale and design of the FINEARTS-HF trial. Eur J Heart Fail. 2024 Jun;26(6):1324-1333. doi: 10.1002/ejhf.3253. Epub 2024 May 14.

    PubMed 38742248

  • Vaduganathan M, Filippatos G, Claggett BL, Desai AS, Jhund PS, Henderson A, Brinker M, Kolkhof P, Schloemer P, Lay-Flurrie J, Viswanathan P, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Rossing P, Ruilope LM, Anker SD, Pitt B, Agarwal R, McMurray JJV, Solomon SD. Finerenone in heart failure and chronic kidney disease with type 2 diabetes: FINE-HEART pooled analysis of cardiovascular, kidney and mortality outcomes. Nat Med. 2024 Dec;30(12):3758-3764. doi: 10.1038/s41591-024-03264-4. Epub 2024 Sep 1.

    PubMed 39218030

  • Vaduganathan M, Neuen BL, McCausland F, Jhund PS, Docherty KF, McMurray JJV, Solomon SD. Why Has it Been Challenging to Modify Kidney Disease Progression in Patients With Heart Failure? J Am Coll Cardiol. 2024 Nov 26;84(22):2241-2245. doi: 10.1016/j.jacc.2024.08.034. Epub 2024 Sep 1. No abstract available.

    PubMed 39217561

  • Lu H, Claggett BL, Ostrominski JW, Pfeffer MA, Pitt B, Jhund PS, McMurray JJV, Solomon SD, Desai AS, Vaduganathan M. Time in blood pressure range and cardiovascular outcomes in HFmrEF/HFpEF: a pooled participant-level analysis of four large-scale trials. Eur J Heart Fail. 2026 Aug 30:xuag245. doi: 10.1093/ejhf/xuag245. Online ahead of print.

    PubMed 42669134

  • Chimura M, Pellicori P, Docherty K, Claggett BL, Campbell RT, Desai AS, Packer M, Jhund PS, Petrie MC, Rouleau JL, Teerlink JR, Vaduganathan M, van Veldhuisen DJ, Zannad F, Zile MR, Solomon SD, McMurray JJV. Low-Normal Hemoglobin Concentrations and Clinical Outcomes in Heart Failure. J Am Coll Cardiol. 2026 Aug 28:S0735-1097(26)07437-1. doi: 10.1016/j.jacc.2026.08.013. Online ahead of print.

    PubMed 42663359

  • Ono R, Docherty KF, Henderson AD, Claggett BL, Desai AS, Lam CSP, Senni M, Shah SJ, Schou M, Voors AA, Amarante F, Lay-Flurrie J, Glasauer A, Zannad F, Vaduganathan M, Jhund PS, Solomon SD, McMurray JJV. HFpEF-ABA Score and Finerenone in Patients With Heart Failure and Mildly Reduced or Preserved Ejection Fraction: Insights From the FINEARTS-HF Trial. JACC Heart Fail. 2026 Aug 27:103297. doi: 10.1016/j.jchf.2026.103297. Online ahead of print.

    PubMed 42663335

  • Boettger P, Sedighi J, Sohns C, Bauersachs J, Assmus B, Sossalla S. Cost-effectiveness of finerenone in heart failure with mildly reduced or preserved ejection fraction - Insights from FINEARTS-HF. Eur J Heart Fail. 2026 May 24:xuag167. doi: 10.1093/ejhf/xuag167. Online ahead of print.

    PubMed 42178507

  • Bains M, Butt JH, Ostrominski JW, Pabon Porras MA, Humphreys-Davies L. Treatment with finerenone in people with heart failure and mildly reduced or preserved ejection fraction: a plain language review. Future Cardiol. 2026 Apr;22(4):323-351. doi: 10.1080/14796678.2026.2650667. Epub 2026 Apr 28.

    PubMed 42047456

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Finerenone (BAY94-8862) in people with Heart Failure, run by Bayer at 661 sites in 37 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 9 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 26 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 661 sites in United States, Japan, China, Russia, Czechia and 32 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

Yes. Results are posted in the registry (first posted 26 Aug 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Occurrence of the Composite Endpoint of Cardiovascular Death and Total (First and Recurrent) Heart Failure Events (time frame: From randomization up until the end of study, with an average study duration of 32 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT04435626, which also lists 46 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Aug 2025.

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FINEARTS-HF Clinical Trial NCT04435626 | AzTrials