StrokeNCT04312269
Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke
A study testing Targeted Memory Reactivation (TMR) in people with Stroke, run by Northwestern University at 1 site in United States.
Trial summary
This study will examine the combination of myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) in chronic stroke survivors. The study aims to determine whether this training-plus-sleep combination will generalize to improve arm motor function over an extended training protocol in… Read more about this study
- Who is it for?
- Ages 21 to 100 years
- Conditions the study is for
- Stroke
- What is being tested?
- Targeted Memory Reactivation (TMR)
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 70 participants
- Where
- 1 siteUnited States
- Study dates
- 25 Feb 2020to 30 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 100 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age at enrollment is 21 or older
- Hemiparesis from first ever stroke affecting arm movement at least 6 months prior to screening
- Severe to moderate motor impairment (FMA-UE of 7-40)
- At least some voluntary shoulder and elbow muscle activation
Who cannot join
- Inability to follow instructions of the MyoCI task
- Visual impairment (such as hemianopia) preventing full view of screen
- Anesthesia or neglect in the affected arm, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest)
- Participation in another study on the affected arm within 6 weeks of enrollment or any pharmacological study
- Inability to understand or follow commands in English due to aphasia or other reason
- Diffuse or multifocal infarcts in both hemispheres
Show all 9Show fewer
- Substantial arm pain preventing participation for 90 minutes a day
- Spasticity treatment (pharmacological or Botox) within last 3 months
- Ferromagnetic implants that are MRI incompatible
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Northwestern University
Chicago, Illinois, 60611
About this study
This study will examine the combination of myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) in chronic stroke survivors. The study aims to determine whether this training-plus-sleep combination will generalize to improve arm motor function over an extended training protocol in stroke survivors.
- Conditions
- Stroke
- Being tested
- Targeted Memory Reactivation (TMR)
- Keywords
- Sleep
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Targeted Memory Reactivation (TMR)Other
Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep.
| Study group | Role | What they receive |
|---|---|---|
| All phase TMR | Experimental | TMR during every stage of sleep Receives: Other: Targeted Memory Reactivation (TMR) |
| Slow-wave sleep (SWS) only TMR | Experimental | TMR during slow-wave sleep only Receives: Other: Targeted Memory Reactivation (TMR) |
| Reduced frequency TMR | Experimental | TMR during only subset of sessions Receives: Other: Targeted Memory Reactivation (TMR) |
| Sham TMR | Sham comparator | Patients receive no TMR Receives: Other: Targeted Memory Reactivation (TMR) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Wolf Motor Function Test (WMFT)
The WMFT evaluates upper extremity function on a continuous scale. It measures the time it takes to perform 15 different tasks, with a time limit of 120 s per task.
Measured: change from baseline at 6 weeks
Secondary outcomes (6)
Fugl-Meyer Assessment of Upper Extremity (UE) Motor Function
The FMA-UE is a measure of impairment. Maximum score is 66 on the motor function portion. Items are scored on a 3-point ordinal scale.
Measured: change from baseline at 6 weeks
Fugl-Meyer Assessment of Upper Extremity (UE) Motor Function
The FMA-UE is a measure of impairment. Maximum score is 66 on the motor function portion. Items are scored on a 3-point ordinal scale.
Measured: change from baseline at 10 weeks
Motor Activity Log (MAL)
The MAL is a validated measure of home-based arm function, both quantity and quality of use in 30 different activities of daily living.
Measured: change from baseline at 6 weeks
Motor Activity Log (MAL)
The MAL is a validated measure of home-based arm function, both quantity and quality of use in 30 different activities of daily living.
Measured: change from baseline at 10 weeks
Modified Ashworth Scale
The Modified Ashworth Scale is a measure of spasticity, which is graded on a scale of 0-4 per joint tested.
Measured: change from baseline at 6 weeks
Modified Ashworth Scale
The Modified Ashworth Scale is a measure of spasticity, which is graded on a scale of 0-4 per joint tested.
Measured: change from baseline at 10 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Mar 2020
- Study start25 Feb 2020
- Primary completion30 Jan 2027 (estimated)
- Study completion30 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- More trials run by Northwestern UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 70 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Northwestern University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Marc Slutzky, Northwestern University
- Investigators
- Marc W Slutzky, MD/PhD, Principal investigator, Northwestern University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04312269
- Sponsor's protocol ID
- SP0052149
- Status last verified
- May 2026
- First submitted
- 9 Mar 2020
- Last updated
- 27 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Clinical functional outcomes and analyzed EMG (co-activation) will be uploaded and shared upon publication.
Study at a glance
From the registry record, last updated by the sponsor on 27 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke
- ClinicalTrials.gov ID
- NCT04312269
- Acronym / sponsor ID
- SP0052149
- Conditions
- Stroke
- Keywords
- Sleep
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 70 participants (estimated)
- Lead sponsor
- Northwestern UniversityUniversity, hospital or other
- Study start
- 25 Feb 2020 (actual)
- Primary completion
- 30 Jan 2027 (estimated)
- Study completion
- 30 Jan 2027 (estimated)
- First posted
- 18 Mar 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will examine the combination of myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) in chronic stroke survivors. The study aims to determine whether this training-plus-sleep combination will generalize to improve arm motor function over an extended training protocol in stroke survivors.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| All phase TMR | Experimental | Other: Targeted Memory Reactivation (TMR)TMR during every stage of sleep |
| Slow-wave sleep (SWS) only TMR | Experimental | Other: Targeted Memory Reactivation (TMR)TMR during slow-wave sleep only |
| Reduced frequency TMR | Experimental | Other: Targeted Memory Reactivation (TMR)TMR during only subset of sessions |
| Sham TMR | Sham comparator | Other: Targeted Memory Reactivation (TMR)Patients receive no TMR |
Who may qualify
- Ages
- 21 to 100 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age at enrollment is 21 or older
- Hemiparesis from first ever stroke affecting arm movement at least 6 months prior to screening
- Severe to moderate motor impairment (FMA-UE of 7-40)
- At least some voluntary shoulder and elbow muscle activation
Key exclusion criteria (9 listed)
- Inability to follow instructions of the MyoCI task
- Visual impairment (such as hemianopia) preventing full view of screen
- Anesthesia or neglect in the affected arm, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest)
- Participation in another study on the affected arm within 6 weeks of enrollment or any pharmacological study
- Inability to understand or follow commands in English due to aphasia or other reason
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Targeted Memory Reactivation (TMR)Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep. | Other | All phase TMR, Reduced frequency TMR, Sham TMR, Slow-wave sleep (SWS) only TMR |
Primary outcome
Wolf Motor Function Test (WMFT)
Time frame: change from baseline at 6 weeks
The WMFT evaluates upper extremity function on a continuous scale. It measures the time it takes to perform 15 different tasks, with a time limit of 120 s per task.
6 secondary outcomes
Fugl-Meyer Assessment of Upper Extremity (UE) Motor Function
Time frame: change from baseline at 6 weeks
Fugl-Meyer Assessment of Upper Extremity (UE) Motor Function
Time frame: change from baseline at 10 weeks
Motor Activity Log (MAL)
Time frame: change from baseline at 6 weeks
Motor Activity Log (MAL)
Time frame: change from baseline at 10 weeks
Modified Ashworth Scale
Time frame: change from baseline at 6 weeks
Modified Ashworth Scale
Time frame: change from baseline at 10 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 May 2026.
- Individual participant dataSharing planned: Yes. Clinical functional outcomes and analyzed EMG (co-activation) will be uploaded and shared upon publication.
Related trials for Stroke
Not yet recruiting
Temporal Interference Stimulation for Upper-Limb Motor Recovery in Early Subacute Stroke
Acute Ischemic Stroke
RecruitingObservational study
ELATE Study: Evaluating Large-vessel Acute Thrombectomy in Extended Time Window
Acute Ichemic Stroke
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Web-Based Tele-Rehabilitation Using Action Observation and Mirror Therapy for Subacute Stroke: A Randomized Controlled Trial
Stroke, Upper Extremity Paresis
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Early Motor-Cognitive Integrative Training on Cognitive and Motor Performance in Patients With Aneurysmal Subarachnoid Hemorrhage
Subarachnoid Aneurysm Hemorrhage
Not yet recruiting
Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery Occlusion
Acute Ischemic Stroke, Basilar Artery Occlusion
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Marc W Slutzky, MD/PhD principal investigator
Northwestern University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Targeted Memory Reactivation (TMR) in people with Stroke, run by Northwestern University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Marc W Slutzky, MD/PhD (312-503-4653, mslutzky@northwestern.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Wolf Motor Function Test (WMFT) (time frame: change from baseline at 6 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 May 2026.