Tooth-lossAlimaPACNCT04281056
Impact of Tooth Loss and Denture on Oral Senses and Food Preferences
A study testing Tooth removal and their replacement by means of a denture in people with Tooth-loss, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
Trial summary
Tooth loss impacts taste abilities and food intake. Present study aims at pertaining the impact of teeth loss and the replacement by means of complete denture on taste and trigeminal abilities, and on food preferences, and taste appetence. Read more about this study
- Who is it for?
- Ages 18 to 79 years
- Conditions the study is for
- Tooth-loss
- What is being tested?
- Tooth removal and their replacement by means of a denture
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteFrance
- Study dates
- 16 Mar 2022to Apr 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 79 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Study Group : being completely edentulous and wearing denture for at least one year, wearing denture during meals, with clean and stable dentures. Controls:
- controls Group : dentate subjects (25 teeth at leas, non endodontically treated) with molars in Angle's Class I occlusion, having no functional disturbance of mastication and not undergoing dental treatment at the time of the recording. Matched with subjects of the study group for age, sex, tabacco consumption, and saliva flow rate.
Who cannot join
- Aged under 18 or over 80 Y,
- not consenting to participate
- suffering from dental
- periodontal or gum pain for the last month.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Yves Boucher, Professor contact
France1 site, 1 recruiting
- Recruiting
Service odontologie Hôpital Rothschild
Paris, 75002
Adeline Braud, Dr, 01 40 19 39 87, adeline.braud@aphp.fr
About this study
Official title: Impact of Complete Tooth Loss and Denture on Oral Sensory Abilities and Food Preference
Tooth loss impacts taste abilities and food intake. Present study aims at pertaining the impact of teeth loss and the replacement by means of complete denture on taste and trigeminal abilities, and on food preferences, and taste appetence.
Read the detailed description
Two groups of participants will be included. Participants wearing complete denture for at least one year (n=20) and their matched controls for age, sex, tobacco, and saliva secretion (n=20). Their oral sensory abilities of participants will be assessed including taste (electrogustometric thresholds, chemical taste identification ability) and trigeminal quantitative sensory testing. Food preferences and selectivity (Maitre et al., 2014) and taste appetence (Deglaire et al., 2012) will also be assessed.
- Conditions
- Tooth-loss
- Being tested
- Tooth removal and their replacement by means of a denture
- Keywords
- Teeth loss, edentulousness, denture, tast, trigeminal senses, oral sensory ability
- Medical subject headings
- Anodontia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Tooth removal and their replacement by means of a dentureProcedure or surgery
Teeth have been removed and replaced by means of dentures for at least one year
| Study group | Role | What they receive |
|---|---|---|
| Control | No intervention | Not described |
| Tooth removal | Experimental | Tooth removal and their replacement by means of a denture Teeth have been removed and replaced by means of dentures for at least one year Receives: Procedure: Tooth removal and their replacement by means of a denture |
What is being measured
The primary outcome is the main question the study is designed to answer.
taste detection thresholds
Using an Electrogustometer
Measured: up to 30 days
Secondary outcomes (4)
Chemical taste identification ability
Using taste strips (Burghard)
Measured: up to 30 days
Quantitative sensory testing
Using an algometer, von frey filament, a thermode.
Measured: up to 30 days
Food preferences and selectivity
Questionnaire food selectyivity and preference (Maitre et al., 2014)
Measured: up to 30 days
Taste appetence
Questionnaire PrefQuest (Deglaire et al., 2012)
Measured: up to 30 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Feb 2020
- Study start16 Mar 2022
- Primary completionApr 2027 (estimated)
- Study completionApr 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tooth-lossStudies of the same condition, open and under way.
- More trials run by Assistance Publique - Hôpitaux de ParisThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Adeline Braud, Doctor, Principal investigator, Assistance Publique - Hôpitaux de Paris
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04281056
- Sponsor's protocol ID
- APHP190340
- Acronym
- AlimaPAC
- Status last verified
- Dec 2025
- First submitted
- 20 Feb 2020
- Last updated
- 19 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 19 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Complete Tooth Loss and Denture on Oral Sensory Abilities and Food Preference
- ClinicalTrials.gov ID
- NCT04281056
- Acronym / sponsor ID
- AlimaPAC / APHP190340
- Conditions
- Tooth-loss
- Keywords
- Teeth loss, edentulousness, denture, tast, trigeminal senses, oral sensory ability
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Assistance Publique - Hôpitaux de ParisUniversity, hospital or other
- Study start
- 16 Mar 2022 (actual)
- Primary completion
- Apr 2027 (estimated)
- Study completion
- Apr 2027 (estimated)
- First posted
- 21 Feb 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Tooth loss impacts taste abilities and food intake. Present study aims at pertaining the impact of teeth loss and the replacement by means of complete denture on taste and trigeminal abilities, and on food preferences, and taste appetence.
Detailed description
Two groups of participants will be included. Participants wearing complete denture for at least one year (n=20) and their matched controls for age, sex, tobacco, and saliva secretion (n=20). Their oral sensory abilities of participants will be assessed including taste (electrogustometric thresholds, chemical taste identification ability) and trigeminal quantitative sensory testing. Food preferences and selectivity (Maitre et al., 2014) and taste appetence (Deglaire et al., 2012) will also be assessed.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Control | No intervention | – |
| Tooth removal | Experimental | Procedure: Tooth removal and their replacement by means of a dentureTooth removal and their replacement by means of a denture Teeth have been removed and replaced by means of dentures for at least one year |
Who may qualify
- Ages
- 18 to 79 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Study Group : being completely edentulous and wearing denture for at least one year, wearing denture during meals, with clean and stable dentures. Controls:
- controls Group : dentate subjects (25 teeth at leas, non endodontically treated) with molars in Angle's Class I occlusion, having no functional disturbance of mastication and not undergoing dental treatment at the time of the recording. Matched with subjects of the study group for age, sex, tabacco consumption, and saliva flow rate.
Key exclusion criteria (4 listed)
- Aged under 18 or over 80 Y,
- not consenting to participate
- suffering from dental
- periodontal or gum pain for the last month.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Tooth removal and their replacement by means of a dentureTeeth have been removed and replaced by means of dentures for at least one year | Procedure or surgery | Tooth removal |
Primary outcome
taste detection thresholds
Time frame: up to 30 days
Using an Electrogustometer
4 secondary outcomes
Chemical taste identification ability
Time frame: up to 30 days
Quantitative sensory testing
Time frame: up to 30 days
Food preferences and selectivity
Time frame: up to 30 days
Taste appetence
Time frame: up to 30 days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Dec 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Yves Boucher, Professor contact
Adeline Braud, Doctor principal investigator
Assistance Publique - Hôpitaux de Paris
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Tooth removal and their replacement by means of a denture in people with Tooth-loss, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 19 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Adeline Braud, Doctor (01 40 19 39 87, adeline.braud@aphp.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
taste detection thresholds (time frame: up to 30 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Dec 2025.