Hematopoietic and Lymphoid Cell NeoplasmNCT04242095

Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects

An observational study of Hematopoietic and Lymphoid Cell Neoplasm and Immune System Disorder, run by Alliance for Clinical Trials in Oncology at 629 sites in United States.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts

Official record

Search all trials

Trial summary

This study collects research data and samples from patients who experience immunotherapy side effects to store for use in future research studies. Studying research data and samples from patients who experience immunotherapy side effects may help researchers better understand how to predict, prevent, and treat these… Read more about this study

Who is it for?: Any age
Conditions the study is for: Hematopoietic and Lymphoid Cell Neoplasm, Immune System Disorder, Malignant Solid Neoplasm
What is being tested?: Biospecimen Collection and Medical Chart Review
Type of treatment: Surgery or procedure
How many people: 2,240 participants
Where: 629 sitesUnited States
Study dates: 12 Mar 2020to 1 Oct 2026
Phase: Observational
Are there results?: Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages Any age
All sexes
No healthy volunteers
Child, Adult, Older adult

Study population: Patients who have received one or more immuno-oncology therapeutics and experienced one or more serious adverse events (AEs)

PRE-REGISTRATION ELIGIBILITY CRITERIA: Planning to receive a regimen containing one or more IO therapeutics
PRE-REGISTRATION ELIGIBILITY CRITERIA: Has not previously been treated with CTLA-4, PD-1 or PD-L1 inhibitors
PRE-REGISTRATION ELIGIBILITY CRITERIA: Willing and able to provide baseline blood and stool samples
REGISTRATION ELIGIBILITY CRITERIA: Received a regimen containing one or more immuno-oncology therapeutics
Must have received one or more IO therapeutics
In addition to one or more IO therapeutics, patients may also have received other therapeutics such as chemotherapy, hormonal or targeted therapy, as long as these are reported
REGISTRATION ELIGIBILITY CRITERIA: Must have experienced one or more of the following:
One or more serious (grade 3-54) AEs that are likely immune-related. AEs included in Common Terminology Criteria for Adverse Events (CTCAE) version (v.) 5.0 that may be immune-related ** Patients who experience only hematologic cytopenia(s) who have received cytotoxic therapies, e.g., chemotherapy, within 60 days prior to registration should be excluded
One or more grade 2 dermatologic, endocrine (except diabetes/hyperglycemia) or rheumatologic AEs that are likely immune-related. AEs included in CTCAE v. 5.0 that may be immune-related
Diagnosis of a rare infection, e.g., fungal or mycobacterial, after starting IO treatment ** Note: Diagnosis of SARS-CoV-2 (COVID-19) is excluded
Hyperprogression. Image submission for patients experiencing hyperprogression is required. For assistance in determining hyperprogression for purposes of eligibility, institutions may contact the study chair and submit images for central review
REGISTRATION ELIGIBILITY CRITERIA: Has not previously been registered to this study * The same patient cannot be enrolled more than once to this study due to development of subsequent irAEs

Trial locations and contacts

629 sites in 1 country. Contact the study team or a site near you to ask about taking part.

David Kozono, MD, PhD contact

617-632-5734

dkozono@bwh.harvard.edu

City, postcode or hospital

Sites recruiting now only

300 sites in 1 country

United States300 sites, 181 recruiting

Providence Regional Cancer System-Aberdeen
Aberdeen, Washington, 98520
Site Public Contact, 360-412-8958, deidre.dillon@providence.org
Alison K. Conlin
Recruiting
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
Active, not recruiting
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
Site Public Contact, 610-402-9543, Morgan_M.Horton@lvhn.org
Elie G. Dib
Recruiting
MyMichigan Medical Center Gratiot
Alma, Michigan, 48801
Site Public Contact, 989-631-2469, CVResearch@mymichigan.org
Elie G. Dib
Recruiting
MyMichigan Medical Center Alpena
Alpena, Michigan, 49707
Site Public Contact, 989-631-2469, CVResearch@mymichigan.org
Elie G. Dib
Recruiting
OSF Saint Anthony's Health Center
Alton, Illinois, 62002
Site Public Contact, 618-463-5623
Jay W. Carlson
Recruiting
The Don and Sybil Harrington Cancer Center
Amarillo, Texas, 79106
Site Public Contact, 806-212-1985, Gina.Cravey@bsahs.org
Anita Ravipati
Recruiting
Mary Greeley Medical Center
Ames, Iowa, 50010
Active, not recruiting
McFarland Clinic - Ames
Ames, Iowa, 50010
Active, not recruiting
Community Hospital of Anaconda
Anaconda, Montana, 59711
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
John M. Schallenkamp
Recruiting
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, 98508
Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org
Alison K. Conlin
Recruiting
Anchorage Radiation Therapy Center
Anchorage, Alaska, 99504
Suspended
Alaska Breast Care and Surgery LLC
Anchorage, Alaska, 99508
Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org
Alison K. Conlin
Recruiting
Alaska Oncology and Hematology LLC
Anchorage, Alaska, 99508
Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org
Alison K. Conlin
Recruiting
Alaska Women's Cancer Care
Anchorage, Alaska, 99508
Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org
Alison K. Conlin
Recruiting
Anchorage Oncology Centre
Anchorage, Alaska, 99508
Suspended
Katmai Oncology Group
Anchorage, Alaska, 99508
Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org
Alison K. Conlin
Recruiting
Providence Alaska Medical Center
Anchorage, Alaska, 99508
Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org
Alison K. Conlin
Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Elie G. Dib
Recruiting
Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
Appleton, Wisconsin, 54915
Site Public Contact, AWRI.inquiry@ascension.org
Jonathan S. Treisman
Recruiting
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, 93420
Active, not recruiting
PCR Oncology
Arroyo Grande, California, 93420
Site Public Contact, 702-384-0013, research@sncrf.org
John A. Ellerton
Recruiting
Hematology Oncology Associates of Central New York-Auburn
Auburn, New York, 13021
Site Public Contact, 315-472-7504
Steven M. Duffy
Recruiting
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado, 80012
Active, not recruiting
Rush-Copley Medical Center
Aurora, Illinois, 60504
Site Public Contact, 630-978-6212, RCMC_Cancer_Research@rush.edu
Suparna Mantha
Recruiting
Advocate Outpatient Center - Aurora
Aurora, Illinois, 60506
Site Public Contact, ncorp@aah.org
Thomas J. Saphner
Recruiting
Saint Alphonsus Cancer Care Center-Baker City
Baker City, Oregon, 97814
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
Elie G. Dib
Recruiting
Mercy Oncology and Hematology - Clayton-Clarkson
Ballwin, Missouri, 63011
Site Public Contact, 888-446-3729
Jay W. Carlson
Recruiting
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, 21201
Active, not recruiting
CommonSpirit Saint Joseph Hospital - Bardstown
Bardstown, Kentucky, 40004
Active, not recruiting
Advocate Good Shepherd Hospital
Barrington, Illinois, 60010
Site Public Contact, 847-842-4847
Thomas J. Saphner
Recruiting
LSU Health Baton Rouge-North Clinic
Baton Rouge, Louisiana, 70805
Site Public Contact, 225-765-7659, research@ololrmc.com
Marshall P. Stagg
Recruiting
Our Lady of the Lake Physician Group
Baton Rouge, Louisiana, 70808
Site Public Contact, 225-765-7659, research@ololrmc.com
Marshall P. Stagg
Recruiting
Our Lady of the Lake Medical Oncology
Baton Rouge, Louisiana, 70817
Site Public Contact, 225-765-7659, research@ololrmc.com
Marshall P. Stagg
Recruiting
Indu and Raj Soin Medical Center
Beavercreek, Ohio, 45431
Active, not recruiting
Nebraska Medicine-Bellevue
Bellevue, Nebraska, 68123
Site Public Contact, 402-559-6941, unmcrsa@unmc.edu
Alissa S. Marr
Recruiting
Overlake Medical Center
Bellevue, Washington, 98004
Suspended
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, 98225
Site Public Contact, 360-788-8223, achapman1@peacehealth.org
Alison K. Conlin
Recruiting
Strecker Cancer Center-Belpre
Belpre, Ohio, 45714
Site Public Contact, 614-488-2745, Jeffh@columbusccop.org
Aruna C. Gowda
Recruiting
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
Site Public Contact, 218-333-5000, OncologyClinicalTrialsFargo@sanfordhealth.org
Daniel Almquist
Recruiting
Saint Charles Health System
Bend, Oregon, 97701
Site Public Contact, 541-706-2909, nosall@stcharleshealthcare.org
Alison K. Conlin
Recruiting
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania, 18017
Site Public Contact, 610-402-9543, Morgan_M.Horton@lvhn.org
Elie G. Dib
Recruiting
Billings Clinic Cancer Center
Billings, Montana, 59101
Site Public Contact, 800-996-2663, research@billingsclinic.org
John M. Schallenkamp
Recruiting
Lourdes Hospital
Binghamton, New York, 13905
Suspended
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501
Site Public Contact, 701-323-5760, OncologyClinicalTrialsFargo@sanfordhealth.org
Daniel Almquist
Recruiting
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
Suspended
Saint Joseph's/Candler - Bluffton Campus
Bluffton, South Carolina, 29910
Active, not recruiting
Saint Elizabeth Boardman Hospital
Boardman, Ohio, 44512
Active, not recruiting
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
Site Public Contact, 734-712-3671, stephanie.couch@stjoeshealth.org
Elie G. Dib
Recruiting
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712
Site Public Contact, 208-381-2774, eslinget@slhs.org
Alison K. Conlin
Recruiting
Central Care Cancer Center - Bolivar
Bolivar, Missouri, 65613
Site Public Contact, 913-948-5588, aroland@kccop.org
Jay W. Carlson
Recruiting
McFarland Clinic - Boone
Boone, Iowa, 50036
Active, not recruiting
Brigham and Women's Hospital
Boston, Massachusetts, 02115
Site Public Contact, 617-724-5200
David E. Kozono
Recruiting
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215
Site Public Contact, 617-667-9925
Hollis Viray
Recruiting
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
Site Public Contact, 877-442-3324
Elad Sharon
Recruiting
Boulder Community Foothills Hospital
Boulder, Colorado, 80303
Active, not recruiting
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, 80304
Active, not recruiting
Bozeman Health Deaconess Hospital
Bozeman, Montana, 59715
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
John M. Schallenkamp
Recruiting
Cox Cancer Center Branson
Branson, Missouri, 65616
Site Public Contact, 417-269-4520
Jay W. Carlson
Recruiting
Lafayette Family Cancer Center-EMMC
Brewer, Maine, 04412
Site Public Contact, 800-987-3005
Sarah J. Sinclair
Recruiting
United Hospital Center
Bridgeport, West Virginia, 26330
Site Public Contact, 304-293-7374, cancertrialsinfo@hsc.wvu.edu
Nour Daboul
Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, 48114
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Elie G. Dib
Recruiting
Trinity Health Medical Center - Brighton
Brighton, Michigan, 48114
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Elie G. Dib
Recruiting
Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
Brookfield, Wisconsin, 53045
Site Public Contact, AWRI.Inquiry@Ascension.org
Jonathan S. Treisman
Recruiting
Saint Joseph Regional Cancer Center
Bryan, Texas, 77802
Active, not recruiting
Roswell Park Cancer Institute
Buffalo, New York, 14263
Site Public Contact, 800-767-9355, askroswell@roswellpark.org
Kannan Thanikachalam
Recruiting
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, 91505
Site Public Contact, 818-847-4793, Najee.Boucher@providence.org
Alison K. Conlin
Recruiting
Highline Medical Center-Main Campus
Burien, Washington, 98166
Active, not recruiting
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin, 53105
Site Public Contact, 414-302-2304, ncorp@aurora.org
Thomas J. Saphner
Recruiting
Fairview Ridges Hospital
Burnsville, Minnesota, 55337
Suspended
Minnesota Oncology - Burnsville
Burnsville, Minnesota, 55337
Site Public Contact, 952-993-1517, mmcorc@healthpartners.com
Yan Ji
Recruiting
Loyola Center for Health at Burr Ridge
Burr Ridge, Illinois, 60527
Suspended
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605
Site Public Contact, 734-712-3671, stephanie.couch@stjoeshealth.org
Elie G. Dib
Recruiting
Cambridge Medical Center
Cambridge, Minnesota, 55008
Suspended
Hematology Oncology Associates of CNY at Camillus
Camillus, New York, 13031
Site Public Contact, 315-472-7504
Steven M. Duffy
Recruiting
Illinois CancerCare-Canton
Canton, Illinois, 61520
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Bryan A. Faller
Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan, 48188
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Elie G. Dib
Recruiting
Trinity Health Medical Center - Canton
Canton, Michigan, 48188
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Elie G. Dib
Recruiting
Mercy Cancer Center - Cape Girardeau
Cape Girardeau, Missouri, 63703
Site Public Contact, 888-446-3729
Jay W. Carlson
Recruiting
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
Site Public Contact, 573-334-2230, sfmc@sfmc.net
Bryan A. Faller
Recruiting
Memorial Hospital of Carbondale
Carbondale, Illinois, 62902
Site Public Contact, 618-457-5200, clinical.research@sih.net
Bryan A. Faller
Recruiting
Mercy Cancer Center - Carmichael
Carmichael, California, 95608
Active, not recruiting
Mercy San Juan Medical Center
Carmichael, California, 95608
Active, not recruiting
Caro Cancer Center
Caro, Michigan, 48723
Suspended
Carson Tahoe Regional Medical Center
Carson City, Nevada, 89703
Site Public Contact, 702-384-0013, research@sncrf.org
John A. Ellerton
Recruiting
SIH Cancer Institute
Carterville, Illinois, 62918
Site Public Contact, 618-985-3333, clinical.research@sih.net
Bryan A. Faller
Recruiting
Illinois CancerCare-Carthage
Carthage, Illinois, 62321
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Bryan A. Faller
Recruiting
Duke Cancer Center Cary
Cary, North Carolina, 27518
Site Public Contact, NCTNStudyTeam@dm.duke.edu
Tucker Coston
Recruiting
Rocky Mountain Cancer Centers - Centennial
Centennial, Colorado, 80112
Active, not recruiting
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio, 45459
Active, not recruiting
Miami Valley Hospital South
Centerville, Ohio, 45459
Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org
Tarek M. Sabagh
Recruiting
Centralia Oncology Clinic
Centralia, Illinois, 62801
Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
Bryan A. Faller
Recruiting
Providence Regional Cancer System-Centralia
Centralia, Washington, 98531
Site Public Contact, 360-412-8958, deidre.dillon@providence.org
Alison K. Conlin
Recruiting
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, 19317
Site Public Contact, 302-623-4450, lbarone@christianacare.org
Gregory A. Masters
Recruiting
Chambersburg Hospital
Chambersburg, Pennsylvania, 17201
Site Public Contact, 773-702-9171, protocols@AllianceNCTN.org
Dan Sotirescu
Recruiting
WellSpan Medical Oncology and Hematology
Chambersburg, Pennsylvania, 17201
Site Public Contact, 717-217-6020
Dan Sotirescu
Recruiting
Chelsea Hospital
Chelsea, Michigan, 48118
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Elie G. Dib
Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, 48118
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Elie G. Dib
Recruiting
Memorial Hospital of Laramie County
Cheyenne, Wyoming, 82001
Site Public Contact, 773-702-9171, protocols@AllianceNCTN.org
John M. Schallenkamp
Recruiting
Swedish Covenant Hospital
Chicago, Illinois, 60625
Site Public Contact, 773-878-8200
Nicklas R. Pfanzelter
Recruiting
Advocate Illinois Masonic Medical Center
Chicago, Illinois, 60657
Site Public Contact, 773-296-5360
Thomas J. Saphner
Recruiting
Adena Regional Medical Center
Chillicothe, Ohio, 45601
Site Public Contact, 877-779-7585, Jeffh@columbusccop.org
Aruna C. Gowda
Recruiting
Ascension Calumet Hospital-Chilton
Chilton, Wisconsin, 53014
Site Public Contact, AWRI.inquiry@ascension.org
Jonathan S. Treisman
Recruiting
Marshfield Clinic-Chippewa Center
Chippewa Falls, Wisconsin, 54729
Suspended
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio, 45219
Active, not recruiting
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, 45220
Active, not recruiting
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229
Site Public Contact, 513-636-2799, cancer@cchmc.org
Robin E. Norris
Recruiting
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio, 45236
Active, not recruiting
Bethesda North Hospital
Cincinnati, Ohio, 45242
Active, not recruiting
TriHealth Cancer Institute-Westside
Cincinnati, Ohio, 45247
Active, not recruiting
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio, 45255
Active, not recruiting
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, 63376
Site Public Contact, 800-600-3606, info@siteman.wustl.edu
George Ansstas
Recruiting
Clackamas Radiation Oncology Center
Clackamas, Oregon, 97015
Site Public Contact, 503-215-2614, CanRsrchStudies@providence.org
Alison K. Conlin
Recruiting
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon, 97015
Suspended
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan, 48346
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Elie G. Dib
Recruiting
Newland Medical Associates-Clarkston
Clarkston, Michigan, 48346
Suspended
Trinity Health IHA Medical Group - Primary Care - Clarkston
Clarkston, Michigan, 48346
Site Public Contact, 248-858-6215, Emily.Crofts@Trinity-Health.org
Elie G. Dib
Recruiting
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325
Suspended
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, 50325
Suspended
Billings Clinic-Cody
Cody, Wyoming, 82414
Site Public Contact, 800-996-2663, research@billingsclinic.org
John M. Schallenkamp
Recruiting
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, 83814
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
John M. Schallenkamp
Recruiting
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
Active, not recruiting
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, 80907
Active, not recruiting
Saint Francis Cancer Center
Colorado Springs, Colorado, 80923
Active, not recruiting
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
Site Public Contact, 800-293-5066, Jamesline@osumc.edu
Alexa S. Meara
Recruiting
Mount Carmel East Hospital
Columbus, Ohio, 43213
Site Public Contact, 614-488-2745, Jeffh@columbusccop.org
Aruna C. Gowda
Recruiting
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio, 43214
Suspended
Riverside Methodist Hospital
Columbus, Ohio, 43214
Suspended
Grant Medical Center
Columbus, Ohio, 43215
Suspended
The Mark H Zangmeister Center
Columbus, Ohio, 43219
Site Public Contact, 614-488-2745, Jeffh@columbusccop.org
Aruna C. Gowda
Recruiting
Mount Carmel Health Center West
Columbus, Ohio, 43222
Site Public Contact, 614-488-2745, Jeffh@columbusccop.org
Aruna C. Gowda
Recruiting
Doctors Hospital
Columbus, Ohio, 43228
Suspended
Mercy Hospital
Coon Rapids, Minnesota, 55433
Site Public Contact, 952-993-1517, mmcorc@healthpartners.com
Yan Ji
Recruiting
Bay Area Hospital
Coos Bay, Oregon, 97420
Suspended
Commonwealth Cancer Center-Corbin
Corbin, Kentucky, 40701
Active, not recruiting
Alegent Health Mercy Hospital
Council Bluffs, Iowa, 51503
Active, not recruiting
Greater Regional Medical Center
Creston, Iowa, 50801
Suspended
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141
Site Public Contact, 800-600-3606, info@siteman.wustl.edu
George Ansstas
Recruiting
AMG Crystal Lake - Oncology
Crystal Lake, Illinois, 60014
Site Public Contact, 630-929-6129, advocateresearch@advocate.com
Thomas J. Saphner
Recruiting
Aurora Saint Luke's South Shore
Cudahy, Wisconsin, 53110
Site Public Contact, 414-302-2304, ncorp@aurora.org
Thomas J. Saphner
Recruiting
Carle at The Riverfront
Danville, Illinois, 61832
Site Public Contact, 800-446-5532, Research@Carle.com
Suparna Mantha
Recruiting
Geisinger Medical Center
Danville, Pennsylvania, 17822
Site Public Contact, 570-271-5251, cancerresearch@geisinger.edu
Rajiv Panikkar
Recruiting
MercyOne Genesis Davenport Medical Center
Davenport, Iowa, 52803
Active, not recruiting
MercyOne Genesis Davenport Cancer Center
Davenport, Iowa, 52804
Active, not recruiting
Iowa Cancer Specialists
Davenport, Iowa, 52807
Active, not recruiting
Miami Valley Hospital
Dayton, Ohio, 45409
Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org
Tarek M. Sabagh
Recruiting
Premier Blood and Cancer Center
Dayton, Ohio, 45409
Site Public Contact, 937-276-8320
Tarek M. Sabagh
Recruiting
Dayton Physician LLC - Englewood
Dayton, Ohio, 45415
Active, not recruiting
Miami Valley Hospital North
Dayton, Ohio, 45415
Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org
Tarek M. Sabagh
Recruiting
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
Bryan A. Faller
Recruiting
Decatur Memorial Hospital
Decatur, Illinois, 62526
Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
Bryan A. Faller
Recruiting
Delaware Health Center-Grady Cancer Center
Delaware, Ohio, 43015
Suspended
Grady Memorial Hospital
Delaware, Ohio, 43015
Suspended
The Women's Imaging Center
Denver, Colorado, 80209
Active, not recruiting
AdventHealth Porter
Denver, Colorado, 80210
Suspended
Colorado Blood Cancer Institute
Denver, Colorado, 80218
Active, not recruiting
Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado, 80218
Active, not recruiting
Rocky Mountain Cancer Centers-Midtown
Denver, Colorado, 80218
Active, not recruiting
Rocky Mountain Cancer Centers-Rose
Denver, Colorado, 80220
Active, not recruiting
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
Active, not recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, 50309
Active, not recruiting
Broadlawns Medical Center
Des Moines, Iowa, 50314
Active, not recruiting
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
Suspended
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, 50314
Suspended
Iowa Lutheran Hospital
Des Moines, Iowa, 50316
Active, not recruiting
Henry Ford Health Saint John Hospital
Detroit, Michigan, 48236
Site Public Contact, 313-343-3166, Kkeenan1@hfhs.org
Elie G. Dib
Recruiting
Illinois CancerCare-Dixon
Dixon, Illinois, 61021
Site Public Contact, 815-285-7800
Bryan A. Faller
Recruiting
Advocate Good Samaritan Hospital
Downers Grove, Illinois, 60515
Site Public Contact, 630-275-1270, Barbara.barhamand@advocatehealth.com
Thomas J. Saphner
Recruiting
Epic Care-Dublin
Dublin, California, 94568
Active, not recruiting
Columbus Oncology and Hematology Associates
Dublin, Ohio, 43016
Suspended
Dublin Methodist Hospital
Dublin, Ohio, 43016
Suspended
CommonSpirit Cancer Center Mercy
Durango, Colorado, 81301
Active, not recruiting
Mercy Medical Center
Durango, Colorado, 81301
Active, not recruiting
Duke University Medical Center
Durham, North Carolina, 27710
Site Public Contact, 888-275-3853
Tucker Coston
Recruiting
Henry Ford River District Hospital
East China Township, Michigan, 48054
Site Public Contact, 313-343-3166, kforman1@hfhs.org
Elie G. Dib
Recruiting
Pocono Medical Center
East Stroudsburg, Pennsylvania, 18301
Site Public Contact, 610-402-9543, Morgan_M.Horton@lvhn.org
Elie G. Dib
Recruiting
Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse, New York, 13057
Site Public Contact, 315-472-7504
Steven M. Duffy
Recruiting
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
Suspended
Fairview Southdale Hospital
Edina, Minnesota, 55435
Site Public Contact, 952-993-1517, mmcorc@healthpartners.com
Yan Ji
Recruiting
Swedish Cancer Institute-Edmonds
Edmonds, Washington, 98026
Site Public Contact, 206-215-2343, PCRC-NCORP@Swedish.org
Alison K. Conlin
Recruiting
Carle Physician Group-Effingham
Effingham, Illinois, 62401
Site Public Contact, 800-446-5532, Research@carle.com
Suparna Mantha
Recruiting
Crossroads Cancer Center
Effingham, Illinois, 62401
Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
Bryan A. Faller
Recruiting
Advocate Sherman Hospital
Elgin, Illinois, 60123
Site Public Contact, 847-429-2907
Thomas J. Saphner
Recruiting
Mercy Cancer Center - Elk Grove
Elk Grove, California, 95758
Active, not recruiting
Christiana Care - Union Hospital
Elkton, Maryland, 21921
Site Public Contact, 410-443-1360, frank.crum@christianacare.org
Gregory A. Masters
Recruiting
Bay Area Breast Surgeons Inc
Emeryville, California, 94608
Active, not recruiting
Epic Care Partners in Cancer Care
Emeryville, California, 94608
Active, not recruiting
Walter Knox Memorial Hospital
Emmett, Idaho, 83617
Suspended
Mountain Blue Cancer Care Center - Swedish
Englewood, Colorado, 80113
Active, not recruiting
Rocky Mountain Cancer Centers - Swedish
Englewood, Colorado, 80113
Active, not recruiting
The Melanoma and Skin Cancer Institute
Englewood, Colorado, 80113
Active, not recruiting
Englewood Hospital and Medical Center
Englewood, New Jersey, 07631
Site Public Contact, 201-894-3456
Meghan Kaumaya
Recruiting
Saint Elizabeth Hospital
Enumclaw, Washington, 98022
Active, not recruiting
Ephrata Cancer Center
Ephrata, Pennsylvania, 17522
Site Public Contact, 717-721-4840
Dan Sotirescu
Recruiting
Ephrata Community Hospital
Ephrata, Pennsylvania, 17522
Site Public Contact, 773-702-9171, protocols@AllianceNCTN.org
Dan Sotirescu
Recruiting
Illinois CancerCare-Eureka
Eureka, Illinois, 61530
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Bryan A. Faller
Recruiting
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois, 60201
Site Public Contact, 847-570-2109
Nicklas R. Pfanzelter
Recruiting
Providence Regional Cancer Partnership
Everett, Washington, 98201
Site Public Contact, 425-261-3529, marilyn.birchman@providence.org
Alison K. Conlin
Recruiting
Fairbanks Memorial Hospital
Fairbanks, Alaska, 99701
Suspended
Sanford South University Medical Center
Fargo, North Dakota, 58103
Site Public Contact, 701-234-6161
Daniel Almquist
Recruiting
Southpointe-Sanford Medical Center Fargo
Fargo, North Dakota, 58103
Site Public Contact, 605-312-3320
Daniel Almquist
Recruiting
Sanford Medical Center Fargo
Fargo, North Dakota, 58104
Site Public Contact, 800-437-4010
Daniel Almquist
Recruiting
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
Site Public Contact, 701-323-5760, OncologyClinicalTrialsFargo@sanfordhealth.org
Daniel Almquist
Recruiting
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
Site Public Contact, 701-234-6161, OncologyClinicalTrialsFargo@sanfordhealth.org
Daniel Almquist
Recruiting
Parkland Health Center - Farmington
Farmington, Missouri, 63640
Site Public Contact, 314-996-5569
Bryan A. Faller
Recruiting
Saint Francis Hospital
Federal Way, Washington, 98003
Active, not recruiting
Armes Family Cancer Center
Findlay, Ohio, 45840
Active, not recruiting
Blanchard Valley Hospital
Findlay, Ohio, 45840
Active, not recruiting
Orion Cancer Care
Findlay, Ohio, 45840
Active, not recruiting
Hunterdon Medical Center
Flemington, New Jersey, 08822
Active, not recruiting
Cancer Hematology Centers - Flint
Flint, Michigan, 48503
Site Public Contact, 810-762-8038, wstrong@ghci.org
Elie G. Dib
Recruiting
Genesee Hematology Oncology PC
Flint, Michigan, 48503
Site Public Contact, 810-762-8038, wstrong@ghci.org
Elie G. Dib
Recruiting
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
Site Public Contact, 810-762-8038, wstrong@ghci.org
Elie G. Dib
Recruiting
Hurley Medical Center
Flint, Michigan, 48503
Site Public Contact, 810-762-8038, wstrong@ghci.org
Elie G. Dib
Recruiting
McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa, 50501
Active, not recruiting
UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge, Iowa, 50501
Active, not recruiting
Holy Cross Hospital
Fort Lauderdale, Florida, 33308
Site Public Contact, eileen.georgi@holy-cross.com
Elie G. Dib
Recruiting
Mercy Hospital Fort Smith
Fort Smith, Arkansas, 72903
Site Public Contact, 800-378-9373
Jay W. Carlson
Recruiting
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, 45005-1066
Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org
Tarek M. Sabagh
Recruiting
Dayton Physicians LLC-Atrium
Franklin, Ohio, 45005
Active, not recruiting
Ascension Southeast Wisconsin Hospital - Franklin
Franklin, Wisconsin, 53132
Site Public Contact, AWRI.Inquiry@Ascension.org
Jonathan S. Treisman
Recruiting
Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
Franklin, Wisconsin, 53132
Site Public Contact, AWRI.Inquiry@Ascension.org
Jonathan S. Treisman
Recruiting
Washington Health
Fremont, California, 94538
Site Public Contact, 510-248-1600
Bogdan S. Eftimie
Recruiting
Unity Hospital
Fridley, Minnesota, 55432
Active, not recruiting
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, 83619
Site Public Contact, 208-381-2774, eslinget@slhs.org
Alison K. Conlin
Recruiting
Central Ohio Breast and Endocrine Surgery
Gahanna, Ohio, 43230
Site Public Contact, 614-488-2745, Jeffh@columbusccop.org
Aruna C. Gowda
Recruiting
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Bryan A. Faller
Recruiting
Western Illinois Cancer Treatment Center
Galesburg, Illinois, 61401
Suspended
Central Care Cancer Center - Garden City
Garden City, Kansas, 67846
Site Public Contact, 913-948-5588, aroland@kccop.org
Jay W. Carlson
Recruiting
CaroMont Regional Medical Center
Gastonia, North Carolina, 28054
Active, not recruiting
Aurora Health Care Germantown Health Center
Germantown, Wisconsin, 53022
Site Public Contact, 414-302-2304, ncorp@aurora.org
Thomas J. Saphner
Recruiting
Adams Cancer Center
Gettysburg, Pennsylvania, 17325
Site Public Contact, 877-441-7957
Dan Sotirescu
Recruiting
MyMichigan Medical Center Gladwin
Gladwin, Michigan, 48624
Site Public Contact, 989-631-2469, CVResearch@mymichigan.org
Elie G. Dib
Recruiting
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie, Maryland, 21061
Active, not recruiting
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois, 60026
Site Public Contact, 847-570-2109
Nicklas R. Pfanzelter
Recruiting
Aurora Cancer Care-Grafton
Grafton, Wisconsin, 53024
Site Public Contact, 414-302-2304, ncorp@aurora.org
Thomas J. Saphner
Recruiting
CHI Health Saint Francis
Grand Island, Nebraska, 68803
Active, not recruiting
Nebraska Cancer Specialists/Oncology Hematology West PC
Grand Island, Nebraska, 68803
Suspended
Grand Valley Oncology
Grand Junction, Colorado, 81505
Site Public Contact, 970-644-4460, gvoclinicaltrials@gjhosp.org
Jonathan D. King
Recruiting
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan, 49503
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org
Elie G. Dib
Recruiting
Central Care Cancer Center - Great Bend
Great Bend, Kansas, 67530
Site Public Contact, 913-948-5588, aroland@kccop.org
Jay W. Carlson
Recruiting
Benefis Sletten Cancer Institute
Great Falls, Montana, 59405
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
John M. Schallenkamp
Recruiting
Great Falls Clinic
Great Falls, Montana, 59405
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
John M. Schallenkamp
Recruiting
Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311
Site Public Contact, 414-302-2304, ncorp@aurora.org
Thomas J. Saphner
Recruiting
East Carolina University
Greenville, North Carolina, 27834
Site Public Contact, 252-744-1015, eubankss@ecu.edu
Mahvish Muzaffar
Recruiting
Dayton Physicians LLC-Wayne
Greenville, Ohio, 45331
Active, not recruiting
Miami Valley Cancer Care and Infusion
Greenville, Ohio, 45331
Site Public Contact, 937-569-7515
Tarek M. Sabagh
Recruiting
Wayne Hospital
Greenville, Ohio, 45331
Active, not recruiting
Saint Francis Hospital
Greenville, South Carolina, 29601
Site Public Contact, 864-603-6234, Heather_Rich@bshsi.org
Stephen H. Dyar
Recruiting
Saint Francis Cancer Center
Greenville, South Carolina, 29607
Site Public Contact, 864-603-6234, Heather_Rich@bshsi.org
Stephen H. Dyar
Recruiting
Henry Ford Saint John Hospital - Academic
Grosse Pointe Woods, Michigan, 48236
Site Public Contact, 313-343-3166, kforman1@hfhs.org
Elie G. Dib
Recruiting
Henry Ford Saint John Hospital - Breast
Grosse Pointe Woods, Michigan, 48236
Site Public Contact, 313-343-3166, karen.forman@ascension.org
Elie G. Dib
Recruiting
Henry Ford Saint John Hospital - Van Elslander
Grosse Pointe Woods, Michigan, 48236
Site Public Contact, 313-343-3166, kforman1@hfhs.org
Elie G. Dib
Recruiting
Mount Carmel Grove City Hospital
Grove City, Ohio, 43123
Site Public Contact, 614-488-2745, Jeffh@columbusccop.org
Aruna C. Gowda
Recruiting
WellSpan Medical Oncology and Hematology
Hanover, Pennsylvania, 17331
Site Public Contact, 717-632-1559
Dan Sotirescu
Recruiting
Hi-Line Sletten Cancer Center
Havre, Montana, 59501
Site Public Contact, 773-702-9171, protocols@AllianceNCTN.org
John M. Schallenkamp
Recruiting
Advocate South Suburban Hospital
Hazel Crest, Illinois, 60429
Site Public Contact, 708-799-9995
Thomas J. Saphner
Recruiting
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, 18201
Site Public Contact, 570-459-2901, cancerresearch@geisinger.edu
Rajiv Panikkar
Recruiting
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania, 18201
Site Public Contact, 610-402-9543, Morgan_M.Horton@lvhn.org
Elie G. Dib
Recruiting
Benefis Helena Specialty Center
Helena, Montana, 59601
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
John M. Schallenkamp
Recruiting
Saint Peter's Community Hospital
Helena, Montana, 59601
Suspended
Cancer and Blood Specialists-Henderson
Henderson, Nevada, 89052
Suspended
Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada, 89052
Site Public Contact, 702-384-0013, research@sncrf.org
John A. Ellerton
Recruiting
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada, 89052
Site Public Contact, 702-384-0013, research@sncrf.org
John A. Ellerton
Recruiting
Las Vegas Cancer Center-Henderson
Henderson, Nevada, 89052
Suspended
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada, 89074
Site Public Contact, 702-384-0013, research@sncrf.org
John A. Ellerton
Recruiting
Las Vegas Urology - Green Valley
Henderson, Nevada, 89074
Suspended
Las Vegas Urology - Pebble
Henderson, Nevada, 89074
Suspended
Oncology Las Vegas - Henderson
Henderson, Nevada, 89074
Site Public Contact, 702-384-0013, research@sncrf.org
John A. Ellerton
Recruiting
Urology Specialists of Nevada - Green Valley
Henderson, Nevada, 89074
Site Public Contact, research@sncrf.org
John A. Ellerton
Recruiting
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina, 28791
Site Public Contact, 828-696-4716, pardeecancerresearch@unchealth.unc.edu
John K. Hill
Recruiting
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois, 60035
Site Public Contact, 847-570-2109
Nicklas R. Pfanzelter
Recruiting
South Carolina Cancer Specialists PC
Hilton Head Island, South Carolina, 29926-3827
Active, not recruiting
Loyola Medicine Homer Glen
Homer Glen, Illinois, 60491
Suspended
Providence Hood River Memorial Hospital
Hood River, Oregon, 97031
Site Public Contact, 503-215-1979, canrsrchstudies@provdience.org
Alison K. Conlin
Recruiting
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs, Arkansas, 71913
Suspended
Swedish Cancer Institute-Issaquah
Issaquah, Washington, 98029
Site Public Contact, 206-215-2343, PCRC-NCORP@Swedish.org
Alison K. Conlin
Recruiting
Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980
Site Public Contact, 855-776-0015
Aaron S. Mansfield
Recruiting
McFarland Clinic - Jefferson
Jefferson, Iowa, 50129
Active, not recruiting
MU Health Care Goldschmidt Cancer Center
Jefferson City, Missouri, 65109
Suspended
Freeman Health System
Joplin, Missouri, 64804
Site Public Contact, 417-347-4030, LJCrockett@freemanhealth.com
Jay W. Carlson
Recruiting
Mercy Hospital Joplin
Joplin, Missouri, 64804
Site Public Contact, 417-556-3074, esmeralda.carrillo@mercy.net
Jay W. Carlson
Recruiting
Logan Health Medical Center
Kalispell, Montana, 59901
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
John M. Schallenkamp
Recruiting
CHI Health Good Samaritan
Kearney, Nebraska, 68847
Active, not recruiting
ECU Health Oncology Kenansville
Kenansville, North Carolina, 28349
Suspended
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, 99336
Site Public Contact, 509-783-4637, research@kadlecmed.org
Alison K. Conlin
Recruiting
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, 53142
Site Public Contact, 414-302-2304, ncorp@aurora.org
Thomas J. Saphner
Recruiting
Greater Dayton Cancer Center
Kettering, Ohio, 45409
Active, not recruiting
First Dayton Cancer Care
Kettering, Ohio, 45420
Suspended
Kettering Medical Center
Kettering, Ohio, 45429
Active, not recruiting
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Bryan A. Faller
Recruiting
Kingman Regional Medical Center
Kingman, Arizona, 86401
Site Public Contact, 702-384-0013, research@sncrf.org
John A. Ellerton
Recruiting
ECU Health Oncology Kinston
Kinston, North Carolina, 28501
Suspended
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
Site Public Contact, 608-775-2385, cancerctr@gundersenhealth.org
Michael O. Ojelabi
Recruiting
Providence Regional Cancer System-Lacey
Lacey, Washington, 98503
Site Public Contact, 360-412-8958, deidre.dillon@providence.org
Alison K. Conlin
Recruiting
Marshfield Medical Center - Ladysmith
Ladysmith, Wisconsin, 54848
Suspended
CommonSpirit Saint Anthony Hospital Cancer Center
Lakewood, Colorado, 80228
Active, not recruiting
Rocky Mountain Cancer Centers-Lakewood
Lakewood, Colorado, 80228
Active, not recruiting
Saint Clare Hospital
Lakewood, Washington, 98499
Active, not recruiting
Fairfield Medical Center
Lancaster, Ohio, 43130
Site Public Contact, 614-488-2745, Jeffh@columbusccop.org
Aruna C. Gowda
Recruiting

Other trials in United States

About this study

Official title: Establishment of a National Biorepository to Advance Studies of Immune-Related Adverse Events

Read the detailed description

PRIMARY OBJECTIVES:

To establish a national biorepository including biospecimen and clinical data collections from patients treated with immuno-oncology (IO) therapeutics who experience one or more serious (grade 3-4) immune-related adverse events (irAEs), rare infections or hyperprogression (acceleration of tumor growth).

OUTLINE:

Patients undergo collection of tissue and blood samples (and optional stool samples from patients experiencing colitis) at the time of registration (within 96 hours of confirmation of one or more severe irAEs) and at 1 month after registration. Patients' medical records are also reviewed for 1 year.

Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Immune System Disorder, Malignant Solid Neoplasm
Being tested: Biospecimen Collection, Medical Chart Review
Medical subject headings: Hematologic Neoplasms, Immune System Diseases

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Biospecimen CollectionProcedure or surgery
Undergo collection of tissue, blood, and stool samples
Medical Chart ReviewOther
Review of medical records

Study groups in NCT04242095
Study group	Role	What they receive
Observational (biospecimen collection, medical record review)		Patients undergo collection of tissue and blood samples (and optional stool samples from patients experiencing colitis) at the time of registration (within 72 hours of confirmation of one or more severe irAEs) and at 1 month after registration. Patients' medical records are also reviewed for up to 1 year. Receives: Procedure: Biospecimen Collection; Other: Medical Chart Review

What is being measured

The primary outcome is the main question the study is designed to answer.

Establishment of a national biorepository including biospecimen and clinical data collections for future use
The objective of this study to establish a biorepository of biospecimen and clinical data. There is no primary clinical outcome for this study.
Measured: Up to 1 year

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

12 Mar 20201 Oct 2026

First posted27 Jan 2020
Study start12 Mar 2020
Primary completion1 Oct 2026 (estimated)
Study completion1 Oct 2026 (estimated)

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for Hematopoietic and Lymphoid Cell NeoplasmStudies of the same condition, open and under way.
More trials run by Alliance for Clinical Trials in OncologyThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Observational
Observational model: Cohort
Time perspective: Prospective
Enrolment: 2,240 participants (estimated)

IDs, dates and publications

ClinicalTrials.gov ID: NCT04242095
Sponsor's protocol ID: A151804
Other IDs: U10CA180821, NCI-2019-07113
Status last verified: Oct 2026
First submitted: 23 Jan 2020
Last updated: 5 Oct 2026
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

Interested in taking part?

David Kozono, MD, PhD

617-632-5734

dkozono@bwh.harvard.edu

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See sites and contacts

RecruitingPhase 1
Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies
Malignancy, Hematologic, Neoplasms, Hematologic
RecruitingPhase 2
Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases
Acute Leukemia of Ambiguous Lineage, Acute Lymphoblastic Leukemia
Not yet recruiting
Virtual Reality Intervention to Improve Comfort in Hospitalized Hematology Patients.
Hematologic Cancer
Active, not recruitingPhase 2
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
RecruitingPhase 1
A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant
Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia

All Hematopoietic and Lymphoid Cell Neoplasm trials

Study at a glance

From the registry record, last updated by the sponsor on 5 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Establishment of a National Biorepository to Advance Studies of Immune-Related Adverse Events
ClinicalTrials.gov ID: NCT04242095
Acronym / sponsor ID: A151804
Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Immune System Disorder, Malignant Solid Neoplasm
Study type: Observational
Recruitment status: Recruiting
Enrolment: 2,240 participants (estimated)
Lead sponsor: Alliance for Clinical Trials in OncologyUniversity, hospital or other
Collaborators: National Cancer Institute (NCI)
Study start: 12 Mar 2020 (actual)
Primary completion: 1 Oct 2026 (estimated)
Study completion: 1 Oct 2026 (estimated)
First posted: 27 Jan 2020 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Detailed description

PRIMARY OBJECTIVES:

OUTLINE:

Study design

Observational model: Cohort
Time perspective: Prospective
Number of arms: 1

Arm	Type	Receives
Observational (biospecimen collection, medical record review)	–	Procedure: Biospecimen Collection, Other: Medical Chart ReviewPatients undergo collection of tissue and blood samples (and optional stool samples from patients experiencing colitis) at the time of registration (within 72 hours of confirmation of one or more severe irAEs) and at 1 month after registration. Patients' medical records are also reviewed for up to 1 year.

Who may qualify

Sex: All
Healthy volunteers: Not accepted
Age groups: Child, Adult, Older adult
Study population: Patients who have received one or more immuno-oncology therapeutics and experienced one or more serious adverse events (AEs)

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Biospecimen CollectionUndergo collection of tissue, blood, and stool samples	Procedure or surgery	Observational (biospecimen collection, medical record review)
Medical Chart ReviewReview of medical records	Other	Observational (biospecimen collection, medical record review)

Primary outcome

Establishment of a national biorepository including biospecimen and clinical data collections for future use
Time frame: Up to 1 year
The objective of this study to establish a biorepository of biospecimen and clinical data. There is no primary clinical outcome for this study.

Results and safety

This study is still under way. Results are not available in the source record yet.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 5 Oct 2026.

Related trials for Hematopoietic and Lymphoid Cell Neoplasm

RecruitingPhase 1
Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies
Malignancy, Hematologic, Neoplasms, Hematologic
RecruitingPhase 2
Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases
Acute Leukemia of Ambiguous Lineage, Acute Lymphoblastic Leukemia
Not yet recruiting
Virtual Reality Intervention to Improve Comfort in Hospitalized Hematology Patients.
Hematologic Cancer
Active, not recruitingPhase 2
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
RecruitingPhase 1
A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant
Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.

David Kozono, MD, PhD contact

617-632-5734

dkozono@bwh.harvard.edu

David Kozono, MD, PhD study chair

Brigham and Women's Hospital

629 sites in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

An observational study of Hematopoietic and Lymphoid Cell Neoplasm and Immune System Disorder, run by Alliance for Clinical Trials in Oncology at 629 sites in United States.

The full registered description is in the About this study section and the official record.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 5 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 629 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact David Kozono, MD, PhD (617-632-5734, dkozono@bwh.harvard.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Establishment of a national biorepository including biospecimen and clinical data collections for future use (time frame: Up to 1 year). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT04242095.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Oct 2026.