Magnetic Resonance AngiographyNCT03768999
Comparison of Magnetic Resonance Coronary Angiography (MRCA) With Coronary Computed Tomography Angiography (CTA)
An observational study of Magnetic Resonance Angiography, run by Johns Hopkins University at 1 site in United States.
Trial summary
Magnetic resonance coronary angiography (MRCA) has its advantage in its ability to assess the coronary artery morphology without radiation or contrast media. The clinical application of MRCA is still challenging mainly because of technical limitations such as: its time-consuming image acquisition, inconsistent image… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Magnetic Resonance Angiography
- What is being tested?
- Non-contrast magnetic resonance coronary angiography (MRCA)
- How many people
- 16 participants
- Where
- 1 siteUnited States
- Study dates
- 3 Sep 2019to 31 Jul 2025
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The candidate for recruitment will be clinical patients who underwent clinical coronary CTA within 6 months.
Who may be able to join
- Participants who underwent clinical coronary CTA within 6 months and allow the study to use the image.
- Willing to sign a consent.
- Overall health status is rated as good/healthy other than suspected coronary artery disease
- Weight is <300 pounds
- Not claustrophobic
- Age: 18 or older
- No clear contraindication against the sublingual nitro administration
Who cannot join
- Previous history of bypass surgery or percutaneous coronary intervention (PCI)
- Metal fragments in the eyes, brain, or spinal cord
- Internal electrical devices, such as a cochlear implant, spinal cord stimulator, pacemaker, or defibrillator
- Pregnancy
- Claustrophobia
- Unstable angina pectoris patients
- Taking phosphodiesterase V inhibitors (If the participant is taking this medication for erectile dysfunction and allowed to stop it for 72 hours before the MRI, the participant can be included in this study.)
- Contraindication to use sublingual nitro administration, such as occlusive glaucoma, known allergy or severe intolerance, critical aortic stenosis. Blood pressure is not included in the exclusion criteria, but when the SBP<110 mmHg just before the cardiac MRI, the participant will not be administered the sublingual nitro.
Trial locations and contacts
1 site in 1 country.
United States1 site
Division of Cardiology, Johns Hopkins University School of Medicine
Baltimore, Maryland, 21287
About this study
Official title: Development of Magnetic Resonance Coronary Angiography (MRCA) Stenosis Assessment Quantification Method by Comparison With Coronary Computed Tomography Angiography (CTA)
Magnetic resonance coronary angiography (MRCA) has its advantage in its ability to assess the coronary artery morphology without radiation or contrast media. The clinical application of MRCA is still challenging mainly because of technical limitations such as: its time-consuming image acquisition, inconsistent image quality, and low spatial resolution. Optimization of MRCA image acquisition method is in progress and compressed sensing (CS) with post-processing (de-noising) by deep learning reconstruction (DLR) is promising to solve these problems.
The lack of a consensus method to assess the coronary stenosis on MRCA is another issue. Generally, a stenosis in MRCA is observed as a signal intensity (SI) drop along the artery compared to the healthy segments. A previous study has reported from its comparison of MRCA with coronary angiography (CAG) that the SI drop of 35% in MRCA stenosis lesion corresponded to the significant stenosis in CAG. Although this SI drop phenomenon was not observed in a different study on chronic total obstruction cases. One of the hypothesized reasons is that the SI drop in MRCA is affected not only by the stenosis severity but also the plaque characteristics, which is not assessable by CAG. To investigate this hypothesis coronary CTA is needed, which is a robust modality to assess coronary stenosis and plaque characteristics. Comparison between MRCA with CTA has the potential to give better information for developing a robust method to assess MRCA.
In this study, the investigators aim to evaluate the feasibility of MRCA scanned with optimized protocol and post-processing, and to develop robust coronary artery assessment method on MRCA, by comparison with clinical coronary CTA.
Read the detailed description
Background:
Diagnosis of significant stenosis of the coronary artery and managing the ischemia is important to prevent cardiac events. Coronary CT angiography (CTA) is one of the current gold standard methods to assess coronary stenosis as well as coronary angiography (CAG), but both coronary CTA and CAG are limited by radiation exposure or contrast media administration.
Magnetic resonance coronary angiography (MRCA) has its advantage in its ability to assess the coronary artery morphology without radiation or contrast media. Unfortunately, the clinical application of MRCA is still challenging mainly because of technical limitation such as its time-consuming image acquisition, inconsistent image quality, and low spatial resolution.
Optimization of MRCA image acquisition process is under great interest and compressed sensing (CS) is one of the promising methods to reduce the acquisition time. Although it's noise-like granular characteristics is a weakness due to its random k-space data acquisition. The granularity may affect the interpretation of the MRCA images considering the small diameter of the coronary arteries. To solve this problem, post-processing denoising approach with deep learning reconstruction (dDLR) is proposed, however too much image smoothing may lead to unfavorable image blurring or produce artefactual smoothing leading to the removal of clinically meaningful signal intensity drops across the artery. Hence, merely assessing the noise level is insufficient. Evaluation of the optimized images with coronary CTA, which is one of the current gold standards, is inevitable to assess its clinical feasibility.
The lack of a consensus method to assess the coronary stenosis on MRCA is another problem. MRCA interpretation is generally performed visually, but its quantification is clinically important to detect the significant stenosis. A previous study has reported by investigating the signal intensity (SI) profile across the coronary artery and its drop of 35% corresponded to significant stenosis by coronary angiography (CAG). Although this SI drop phenomenon was not observed in a different study on chronic total obstruction cases. One of the hypothesized reasons is that the SI drop in MRCA is affected not only by the stenosis severity but also the plaque characteristics, which is not assessable by CAG. To confirm this hypothesis coronary CTA is needed, which is a robust modality to assess coronary stenosis and plaque characteristics. Comparison between MRCA with CTA has the potential to give better information for developing a robust method to assess MRCA.
In this study, the investigators aim to evaluate the feasibility of MRCA scanned with optimized protocol and post-processing, and to develop robust coronary artery assessment method on MRCA, by comparison with clinical coronary CTA.
Study Procedures:
This is a prospective, non-randomized study. Overall 50 participants in total will be recruited within 12 months. Each participant will undergo one non-contrast MRI.
The candidate for recruitment will be clinical patients who underwent clinical coronary CTA within 6 months. Candidate participant selection will be performed by investigating the electronic medical record (EMR). Then the candidate participants will receive a phone screening using a questionnaire which contents are corresponding to the inclusion and exclusion criteria (which will be described later). When the candidate fulfills all the criteria and if the person gives consent, the investigators will recruit the person into this study. The written consent will be obtained at the MRI preparation room from one of the study team members. The consent to use the previously scanned coronary CTA is obtained at the same time of consent for the MRI, although the investigators do not include the clinical CTA acquisition into this study protocol because it is a routine clinical care that performed previously.
Before the MRI scanning, the participant will get blood pressure measurement to confirm the systolic blood pressure (SBP) ≥110 mmHg, which is an inclusion criteria for a sublingual nitro tablet be administered to the participant in advance to the MRI. Sublingual nitro tablet administration is aimed to dilate the coronary artery, which is a routine procedure in coronary CTA as well. When the SBP was <110 mmHg, then the participant will not receive the sublingual nitro. The participant will undergo non-contrast cardiac MRI, including non-contrast whole heart MRI with T2-prepared segmented fast low-angle shot 3D spoiled gradient echo sequence with ECG-gating, diaphragm navigator-gating, and fat suppression. All the scans will be performed with a 3 Tesla Vantage Galan scanner (Canon Medical systems). After the acquisition, the MRI data will be reconstructed and then undergo post-processing denoising. The DICOM images will be anonymized and stored in a folder for this study inside Hopkins network.
The MRCA and CTA image assessment will be performed from anonymized images on workstations with suitable function.
- Conditions
- Magnetic Resonance Angiography
- Being tested
- Non-contrast magnetic resonance coronary angiography (MRCA)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Non-contrast magnetic resonance coronary angiography (MRCA)Diagnostic test
Scan non-contrast MRCA and compare the image with clinically scanned coronary computed tomography angiography (CTA).
| Study group | Role | What they receive |
|---|---|---|
| Study group | All participants in the study to receive Non-contrast magnetic resonance coronary angiography (MRCA) Receives: Diagnostic Test: Non-contrast magnetic resonance coronary angiography (MRCA) |
What is being measured
The primary outcome is the main question the study is designed to answer.
The SI drop (%) threshold that corresponds to the significant stenosis in coronary CTA.
MRCA signal intensity change compared to the proximal or distal segments of the coronary artery will be measured and compared with corresponding lesion of coronary CTA. The threshold of SI drop (%) which corresponds to the significant stenosis in CTA will be assessed.
Measured: After the last participant MRI scan, up to 6 months
Secondary outcomes (2)
Semi-quantitative image quality assessment score for each segments in MRCA
Image quality assessed by categorical numbers score ranging from 1 to 4 with higher scores indicating better image quality.
Measured: After participant's MRI scan, up to 2 weeks
Visible coronary length in MRCA
The length of the coronary arteries in mm that is visually assessable which are compared with coronary CTA
Measured: After participant's MRI scan, up to 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Dec 2018
- Study start3 Sep 2019
- Primary completion31 Jul 2025
- Study completion31 Jul 2025
Why it stopped: Because of COVID 19 we experienced slow pace of recruitment.
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (9)Papers the sponsor has linked to this study.
- Other trials for Magnetic Resonance AngiographyStudies of the same condition, open and under way.
- More trials run by Johns Hopkins UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 16 participants (actual)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Johns Hopkins University
- Sponsor type
- University, hospital or other
- Collaborators
- Canon Medical Systems, USA
- Responsible party
- Sponsor
- Investigators
- Joao AC Lima, MD, Principal investigator, Johns Hopkins University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03768999
- Sponsor's protocol ID
- IRB00196000
- Status last verified
- Aug 2025
- First submitted
- 4 Dec 2018
- Last updated
- 12 Aug 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Sakuma H, Ichikawa Y, Suzawa N, Hirano T, Makino K, Koyama N, Van Cauteren M, Takeda K. Assessment of coronary arteries with total study time of less than 30 minutes by using whole-heart coronary MR angiography. Radiology. 2005 Oct;237(1):316-21. doi: 10.1148/radiol.2371040830. Epub 2005 Aug 26.
PubMed 16126921Akcakaya M, Basha TA, Chan RH, Rayatzadeh H, Kissinger KV, Goddu B, Goepfert LA, Manning WJ, Nezafat R. Accelerated contrast-enhanced whole-heart coronary MRI using low-dimensional-structure self-learning and thresholding. Magn Reson Med. 2012 May;67(5):1434-43. doi: 10.1002/mrm.24242. Epub 2012 Mar 5.
PubMed 22392654Akcakaya M, Basha TA, Chan RH, Manning WJ, Nezafat R. Accelerated isotropic sub-millimeter whole-heart coronary MRI: compressed sensing versus parallel imaging. Magn Reson Med. 2014 Feb;71(2):815-22. doi: 10.1002/mrm.24683.
PubMed 23440946Nam S, Akcakaya M, Basha T, Stehning C, Manning WJ, Tarokh V, Nezafat R. Compressed sensing reconstruction for whole-heart imaging with 3D radial trajectories: a graphics processing unit implementation. Magn Reson Med. 2013 Jan;69(1):91-102. doi: 10.1002/mrm.24234. Epub 2012 Mar 5.
PubMed 22392604Nakamura M, Kido T, Kido T, Watanabe K, Schmidt M, Forman C, Mochizuki T. Non-contrast compressed sensing whole-heart coronary magnetic resonance angiography at 3T: A comparison with conventional imaging. Eur J Radiol. 2018 Jul;104:43-48. doi: 10.1016/j.ejrad.2018.04.025. Epub 2018 Apr 27.
PubMed 29857865Isogawa K, Ida T, Shiodera T, Takeguchi T. Deep Shrinkage Convolutional Neural Network for Adaptive Noise Reduction. IEEE Signal Process Lett. 2018;25: 224-228. doi:10.1109/LSP.2017.2782270
Yonezawa M, Nagata M, Kitagawa K, Kato S, Yoon Y, Nakajima H, Nakamori S, Sakuma H, Hatakenaka M, Honda H. Quantitative analysis of 1.5-T whole-heart coronary MR angiograms obtained with 32-channel cardiac coils: a comparison with conventional quantitative coronary angiography. Radiology. 2014 May;271(2):356-64. doi: 10.1148/radiol.13122491. Epub 2013 Dec 12.
PubMed 24475794Kim SM, Choi JH, Choe YH. Coronary Artery Total Occlusion: MR Angiographic Imaging Findings and Success Rates of Percutaneous Coronary Intervention according to Intraluminal Signal Intensity Patterns. Radiology. 2016 Apr;279(1):84-92. doi: 10.1148/radiol.2015150191. Epub 2015 Oct 13.
PubMed 26465057Kato Y, Noda C, Ambale-Venkatesh B, Ortman JM, Kassai Y, Lima JAC, Liu CY. The mechanisms of arterial signal intensity profile in non-contrast coronary MRA (NC-MRCA): a 3D printed phantom investigation and clinical translations. Int J Cardiovasc Imaging. 2023 Jan;39(1):209-220. doi: 10.1007/s10554-022-02700-1. Epub 2022 Aug 11.
PubMed 36598690
Study at a glance
From the registry record, last updated by the sponsor on 12 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Development of Magnetic Resonance Coronary Angiography (MRCA) Stenosis Assessment Quantification Method by Comparison With Coronary Computed Tomography Angiography (CTA)
- ClinicalTrials.gov ID
- NCT03768999
- Acronym / sponsor ID
- IRB00196000
- Conditions
- Magnetic Resonance Angiography
- Study type
- Observational
- Recruitment status
- TerminatedReason stopped: Because of COVID 19 we experienced slow pace of recruitment.
- Enrolment
- 16 participants (actual)
- Lead sponsor
- Johns Hopkins UniversityUniversity, hospital or other
- Collaborators
- Canon Medical Systems, USA
- Study start
- 3 Sep 2019 (actual)
- Primary completion
- 31 Jul 2025 (actual)
- Study completion
- 31 Jul 2025 (actual)
- First posted
- 7 Dec 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Magnetic resonance coronary angiography (MRCA) has its advantage in its ability to assess the coronary artery morphology without radiation or contrast media. The clinical application of MRCA is still challenging mainly because of technical limitations such as: its time-consuming image acquisition, inconsistent image quality, and low spatial resolution. Optimization of MRCA image acquisition method is in progress and compressed sensing (CS) with post-processing (de-noising) by deep learning reconstruction (DLR) is promising to solve these problems.
The lack of a consensus method to assess the coronary stenosis on MRCA is another issue. Generally, a stenosis in MRCA is observed as a signal intensity (SI) drop along the artery compared to the healthy segments. A previous study has reported from its comparison of MRCA with coronary angiography (CAG) that the SI drop of 35% in MRCA stenosis lesion corresponded to the significant stenosis in CAG. Although this SI drop phenomenon was not observed in a different study on chronic total obstruction cases. One of the hypothesized reasons is that the SI drop in MRCA is affected not only by the stenosis severity but also the plaque characteristics, which is not assessable by CAG. To investigate this hypothesis coronary CTA is needed, which is a robust modality to assess coronary stenosis and plaque characteristics. Comparison between MRCA with CTA has the potential to give better information for developing a robust method to assess MRCA.
In this study, the investigators aim to evaluate the feasibility of MRCA scanned with optimized protocol and post-processing, and to develop robust coronary artery assessment method on MRCA, by comparison with clinical coronary CTA.
Detailed description
Background:
Diagnosis of significant stenosis of the coronary artery and managing the ischemia is important to prevent cardiac events. Coronary CT angiography (CTA) is one of the current gold standard methods to assess coronary stenosis as well as coronary angiography (CAG), but both coronary CTA and CAG are limited by radiation exposure or contrast media administration.
Magnetic resonance coronary angiography (MRCA) has its advantage in its ability to assess the coronary artery morphology without radiation or contrast media. Unfortunately, the clinical application of MRCA is still challenging mainly because of technical limitation such as its time-consuming image acquisition, inconsistent image quality, and low spatial resolution.
Optimization of MRCA image acquisition process is under great interest and compressed sensing (CS) is one of the promising methods to reduce the acquisition time. Although it's noise-like granular characteristics is a weakness due to its random k-space data acquisition. The granularity may affect the interpretation of the MRCA images considering the small diameter of the coronary arteries. To solve this problem, post-processing denoising approach with deep learning reconstruction (dDLR) is proposed, however too much image smoothing may lead to unfavorable image blurring or produce artefactual smoothing leading to the removal of clinically meaningful signal intensity drops across the artery. Hence, merely assessing the noise level is insufficient. Evaluation of the optimized images with coronary CTA, which is one of the current gold standards, is inevitable to assess its clinical feasibility.
The lack of a consensus method to assess the coronary stenosis on MRCA is another problem. MRCA interpretation is generally performed visually, but its quantification is clinically important to detect the significant stenosis. A previous study has reported by investigating the signal intensity (SI) profile across the coronary artery and its drop of 35% corresponded to significant stenosis by coronary angiography (CAG). Although this SI drop phenomenon was not observed in a different study on chronic total obstruction cases. One of the hypothesized reasons is that the SI drop in MRCA is affected not only by the stenosis severity but also the plaque characteristics, which is not assessable by CAG. To confirm this hypothesis coronary CTA is needed, which is a robust modality to assess coronary stenosis and plaque characteristics. Comparison between MRCA with CTA has the potential to give better information for developing a robust method to assess MRCA.
In this study, the investigators aim to evaluate the feasibility of MRCA scanned with optimized protocol and post-processing, and to develop robust coronary artery assessment method on MRCA, by comparison with clinical coronary CTA.
Study Procedures:
This is a prospective, non-randomized study. Overall 50 participants in total will be recruited within 12 months. Each participant will undergo one non-contrast MRI.
The candidate for recruitment will be clinical patients who underwent clinical coronary CTA within 6 months. Candidate participant selection will be performed by investigating the electronic medical record (EMR). Then the candidate participants will receive a phone screening using a questionnaire which contents are corresponding to the inclusion and exclusion criteria (which will be described later). When the candidate fulfills all the criteria and if the person gives consent, the investigators will recruit the person into this study. The written consent will be obtained at the MRI preparation room from one of the study team members. The consent to use the previously scanned coronary CTA is obtained at the same time of consent for the MRI, although the investigators do not include the clinical CTA acquisition into this study protocol because it is a routine clinical care that performed previously.
Before the MRI scanning, the participant will get blood pressure measurement to confirm the systolic blood pressure (SBP) ≥110 mmHg, which is an inclusion criteria for a sublingual nitro tablet be administered to the participant in advance to the MRI. Sublingual nitro tablet administration is aimed to dilate the coronary artery, which is a routine procedure in coronary CTA as well. When the SBP was <110 mmHg, then the participant will not receive the sublingual nitro. The participant will undergo non-contrast cardiac MRI, including non-contrast whole heart MRI with T2-prepared segmented fast low-angle shot 3D spoiled gradient echo sequence with ECG-gating, diaphragm navigator-gating, and fat suppression. All the scans will be performed with a 3 Tesla Vantage Galan scanner (Canon Medical systems). After the acquisition, the MRI data will be reconstructed and then undergo post-processing denoising. The DICOM images will be anonymized and stored in a folder for this study inside Hopkins network.
The MRCA and CTA image assessment will be performed from anonymized images on workstations with suitable function.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 1 Day
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Study group | – | Diagnostic Test: Non-contrast magnetic resonance coronary angiography (MRCA)All participants in the study to receive Non-contrast magnetic resonance coronary angiography (MRCA) |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The candidate for recruitment will be clinical patients who underwent clinical coronary CTA within 6 months.
Key inclusion criteria (7 listed)
- Participants who underwent clinical coronary CTA within 6 months and allow the study to use the image.
- Willing to sign a consent.
- Overall health status is rated as good/healthy other than suspected coronary artery disease
- Weight is <300 pounds
- Not claustrophobic
Key exclusion criteria (8 listed)
- Previous history of bypass surgery or percutaneous coronary intervention (PCI)
- Metal fragments in the eyes, brain, or spinal cord
- Internal electrical devices, such as a cochlear implant, spinal cord stimulator, pacemaker, or defibrillator
- Pregnancy
- Claustrophobia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Non-contrast magnetic resonance coronary angiography (MRCA)Scan non-contrast MRCA and compare the image with clinically scanned coronary computed tomography angiography (CTA). | Diagnostic test | Study group |
Primary outcome
The SI drop (%) threshold that corresponds to the significant stenosis in coronary CTA.
Time frame: After the last participant MRI scan, up to 6 months
MRCA signal intensity change compared to the proximal or distal segments of the coronary artery will be measured and compared with corresponding lesion of coronary CTA. The threshold of SI drop (%) which corresponds to the significant stenosis in CTA will be assessed.
2 secondary outcomes
Semi-quantitative image quality assessment score for each segments in MRCA
Time frame: After participant's MRI scan, up to 2 weeks
Visible coronary length in MRCA
Time frame: After participant's MRI scan, up to 2 weeks
Results and safety
The study was stopped early (reason given: Because of COVID 19 we experienced slow pace of recruitment.). Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Aug 2025.
- Background: PubMed 16126921Sakuma H, Ichikawa Y, Suzawa N, Hirano T, Makino K, Koyama N, Van Cauteren M, Takeda K. Assessment of coronary arteries with total study time of less than 30 minutes by using whole-heart coronary MR angiography. Radiology. 2005 Oct;237(1):316-21. doi: 10.1148/radiol.2371040830. Epub 2005 Aug 26.
- Background: PubMed 22392654Akcakaya M, Basha TA, Chan RH, Rayatzadeh H, Kissinger KV, Goddu B, Goepfert LA, Manning WJ, Nezafat R. Accelerated contrast-enhanced whole-heart coronary MRI using low-dimensional-structure self-learning and thresholding. Magn Reson Med. 2012 May;67(5):1434-43. doi: 10.1002/mrm.24242. Epub 2012 Mar 5.
- Background: PubMed 23440946Akcakaya M, Basha TA, Chan RH, Manning WJ, Nezafat R. Accelerated isotropic sub-millimeter whole-heart coronary MRI: compressed sensing versus parallel imaging. Magn Reson Med. 2014 Feb;71(2):815-22. doi: 10.1002/mrm.24683.
- Background: PubMed 22392604Nam S, Akcakaya M, Basha T, Stehning C, Manning WJ, Tarokh V, Nezafat R. Compressed sensing reconstruction for whole-heart imaging with 3D radial trajectories: a graphics processing unit implementation. Magn Reson Med. 2013 Jan;69(1):91-102. doi: 10.1002/mrm.24234. Epub 2012 Mar 5.
- Background: PubMed 29857865Nakamura M, Kido T, Kido T, Watanabe K, Schmidt M, Forman C, Mochizuki T. Non-contrast compressed sensing whole-heart coronary magnetic resonance angiography at 3T: A comparison with conventional imaging. Eur J Radiol. 2018 Jul;104:43-48. doi: 10.1016/j.ejrad.2018.04.025. Epub 2018 Apr 27.
- BackgroundIsogawa K, Ida T, Shiodera T, Takeguchi T. Deep Shrinkage Convolutional Neural Network for Adaptive Noise Reduction. IEEE Signal Process Lett. 2018;25: 224-228. doi:10.1109/LSP.2017.2782270
- Background: PubMed 24475794Yonezawa M, Nagata M, Kitagawa K, Kato S, Yoon Y, Nakajima H, Nakamori S, Sakuma H, Hatakenaka M, Honda H. Quantitative analysis of 1.5-T whole-heart coronary MR angiograms obtained with 32-channel cardiac coils: a comparison with conventional quantitative coronary angiography. Radiology. 2014 May;271(2):356-64. doi: 10.1148/radiol.13122491. Epub 2013 Dec 12.
- Background: PubMed 26465057Kim SM, Choi JH, Choe YH. Coronary Artery Total Occlusion: MR Angiographic Imaging Findings and Success Rates of Percutaneous Coronary Intervention according to Intraluminal Signal Intensity Patterns. Radiology. 2016 Apr;279(1):84-92. doi: 10.1148/radiol.2015150191. Epub 2015 Oct 13.
- Derived from this study: PubMed 36598690Kato Y, Noda C, Ambale-Venkatesh B, Ortman JM, Kassai Y, Lima JAC, Liu CY. The mechanisms of arterial signal intensity profile in non-contrast coronary MRA (NC-MRCA): a 3D printed phantom investigation and clinical translations. Int J Cardiovasc Imaging. 2023 Jan;39(1):209-220. doi: 10.1007/s10554-022-02700-1. Epub 2022 Aug 11.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Joao AC Lima, MD principal investigator
Johns Hopkins University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Magnetic Resonance Angiography, run by Johns Hopkins University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 12 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was stopped early (reason given: Because of COVID 19 we experienced slow pace of recruitment.). Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The SI drop (%) threshold that corresponds to the significant stenosis in coronary CTA. (time frame: After the last participant MRI scan, up to 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03768999, which also lists 9 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Aug 2025.