Cardiorenal SyndromeDECONGESTNCT03684876
Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery
An observational study of Cardiorenal Syndrome, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
Trial summary
Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow. The investigator's standard care includes use of diuretic to avoid interstitial fluid accumulation. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiorenal Syndrome
- What is being tested?
- diuretic use
- Type of treatment
- Surgery or procedure
- How many people
- 9 participants
- Where
- 1 siteFrance
- Study dates
- 1 Jun 2018to 1 Jun 2020
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: patient age >=18 years
Who may be able to join
- patient undergoing elective cardiac surgery under cardiopulmonary bypass
Who cannot join
- heart transplantation
- use of vasopressor
- chronic renal disease (DGF under 30 ml min-1)
- endocarditis
- patient under ECLS or CPIA
- patient under 18-year-old
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery: a Prospective Observational Study
Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow. The investigator's standard care includes use of diuretic to avoid interstitial fluid accumulation. The aim of the study is to assess cardiac and renal function before and after depletion by using diuretics
Read the detailed description
The study will compare cardiac and renal data before and 6 hours after use of diuretic
- Echocardiographic measure of right function (S wave, TAPSE, ventricle surfaces, inferior vena cava diameter) and left function (LVEF, cardiac output
- Renal function: cumulative diuresis, creatinine level variation and incidence of acute kidney injury using KDIGO classification (creatinine level>26.5 or diuresis<0.05 ml kg-1 h-1)
- Conditions
- Cardiorenal Syndrome
- Being tested
- diuretic use
- Keywords
- cardiac surgery, venous congestion, diuretic depletion
- Medical subject headings
- Cardio-Renal Syndrome, Hyperemia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
diuretic useProcedure or surgery
use of diuretic
What is being measured
The primary outcome is the main question the study is designed to answer.
change in renal glomerular filtration before and 6 hours after use of diurectic
change in renal glomerular filtration before and 6 hours after use of diurectic
Measured: at baseline (o hours) and 6 hours after use of diuretic
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Sep 2018
- Study start1 Jun 2018
- Primary completion1 Jun 2020
- Study completion1 Jun 2020
Why it stopped: Recruitment difficulties
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiorenal SyndromeStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire, AmiensThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 9 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire, Amiens
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03684876
- Sponsor's protocol ID
- PI2018_843_0012
- Acronym
- DECONGEST
- Status last verified
- Jun 2026
- First submitted
- 5 Jul 2018
- Last updated
- 25 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery: a Prospective Observational Study
- ClinicalTrials.gov ID
- NCT03684876
- Acronym / sponsor ID
- DECONGEST / PI2018_843_0012
- Conditions
- Cardiorenal Syndrome
- Keywords
- cardiac surgery, venous congestion, diuretic depletion
- Study type
- Observational
- Recruitment status
- TerminatedReason stopped: Recruitment difficulties
- Enrolment
- 9 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire, AmiensUniversity, hospital or other
- Study start
- 1 Jun 2018 (actual)
- Primary completion
- 1 Jun 2020 (actual)
- Study completion
- 1 Jun 2020 (actual)
- First posted
- 26 Sep 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow. The investigator's standard care includes use of diuretic to avoid interstitial fluid accumulation. The aim of the study is to assess cardiac and renal function before and after depletion by using diuretics
Detailed description
The study will compare cardiac and renal data before and 6 hours after use of diuretic
- Echocardiographic measure of right function (S wave, TAPSE, ventricle surfaces, inferior vena cava diameter) and left function (LVEF, cardiac output
- Renal function: cumulative diuresis, creatinine level variation and incidence of acute kidney injury using KDIGO classification (creatinine level>26.5 or diuresis<0.05 ml kg-1 h-1)
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- patient age >=18 years
Key inclusion criteria (1 listed)
- patient undergoing elective cardiac surgery under cardiopulmonary bypass
Key exclusion criteria (6 listed)
- heart transplantation
- use of vasopressor
- chronic renal disease (DGF under 30 ml min-1)
- endocarditis
- patient under ECLS or CPIA
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| diuretic useuse of diuretic | Procedure or surgery | – |
Primary outcome
change in renal glomerular filtration before and 6 hours after use of diurectic
Time frame: at baseline (o hours) and 6 hours after use of diuretic
change in renal glomerular filtration before and 6 hours after use of diurectic
Results and safety
The study was stopped early (reason given: Recruitment difficulties). Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Jun 2026.
- Individual participant dataSharing planned: No
Related trials for Cardiorenal Syndrome
Not yet recruiting
Community Health Worker Nutrition Self-Management Support for Cardio-Kidney-Metabolic Health
Hypertension (HTN), CKD - Chronic Kidney Disease
Recruiting
Optimised Cardiovascular and Renal Protection in Patients With Chronic Kidney Disease and Cardiovascular Disease
Chronic Kidney Disease, Heart Failure With Preserved Ejection Fraction (HFPEF)
Active, not recruitingObservational study
Monitoring of the Sympathetic/Vagal Balance Through Multiparametric Analysis of Heart Rate Variability (HRV)
Diabete Type 2, Heart Failure
Recruiting
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
Heart Failure, Cardiorenal Syndrome
Not yet recruitingPhase 4
Effect of Secukinumab on Cardiorenal Outcomes in Patients With Cardiorenal Metabolic Syndrome and Atherosclerotic Cardiovascular Disease
Cardiorenal Metabolic Syndrome, Atherosclerotic Cardiovascular Disease
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiorenal Syndrome, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 25 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was stopped early (reason given: Recruitment difficulties). Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
change in renal glomerular filtration before and 6 hours after use of diurectic (time frame: at baseline (o hours) and 6 hours after use of diuretic). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Jun 2026.