AzTrials
AzTrials

Castration Levels of TestosteronePhase 3NCT03678025

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

A Phase 3 study testing Abiraterone, Bicalutamide and Degarelix in people with Castration Levels of Testosterone and Metastatic Prostatic Adenocarcinoma, run by SWOG Cancer Research Network at 338 sites in 5 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Read more about this study

Who is it for?
Ages 18 years and older, men only
What is being tested?
Abiraterone, Bicalutamide and Degarelix
Could I receive a placebo?
No, everyone receives an active treatment
How many people
1,273 participants
Where
338 sitesin 5 countries
Study dates
24 Sep 2018to 1 Oct 2036
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • Men only
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: All patients must have a histologically or cytologically proven diagnosis of adenocarcinoma of the prostate. Patients with pure small cell carcinoma* (SCC), sarcomatoid, or squamous cell carcinoma are not eligible. (*morphology must be consistent with SCC; synaptophysin or chromogranin positive by immunohistochemical staining is insufficient to diagnose SCC).
  • STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: Patients must have an intact prostate. No prior local therapy for prostate adenocarcinoma is allowed (e.g., brachytherapy, high-intensity focused ultrasound [HIFU], cryotherapy, laser ablative therapies). Any prior therapy for benign conditions, such as obstruction, are acceptable (e.g., transurethral resection of the prostate, greenlight laser ablation, microwave ablation).
  • STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: Patients must have evidence of metastatic disease on technetium bone scan and computed tomography (CT) or magnetic resonance imaging (MRI) within 42 days prior to starting standard systemic therapy. Metastatic disease that is detected by positron emission tomography (PET) scan only (sodium fluoride [NaF], prostate-specific membrane antigen [PSMA], anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid [FACBC], carbon [C]11) but not conventional imaging (technetium [Tc]99 bone scan, CT or MRI) or solitary metastases by conventional imaging, must be confirmed histologically or cytologically.
  • STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: Patients with known brain metastases are not eligible. Brain imaging studies are not required for eligibility if the patient has no neurologic signs or symptoms suggestive of brain metastasis. If brain imaging studies are performed, they must be negative for disease.
  • STEP 1 REGISTRATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must have received no more than 28 weeks of standard systemic therapy (SST). SST is defined as current National Comprehensive Cancer Network (NCCN) guidelines for metastatic prostate cancer.
  • STEP 1 REGISTRATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must not have progressed while on SST.
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  • STEP 1 REGISTRATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients with oligometastatic prostate cancer may receive metastasis directed therapy to up to four sites of disease prior to randomization.
  • STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: Patients must have a complete physical examination and medical history within 28 days prior to registration.
  • STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: Patients must have a PSA documented prior to initiation of SST and within 28 days prior to registration. Any additional PSAs measured while receiving SST should be recorded.
  • STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: Patients must have a testosterone lab documented within 28 days prior to randomization. Any additional testosterone labs measured while receiving SST should be recorded as well as pretreatment initiation if available.
  • STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, adequately treated stage 0, I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years.
  • STEP 1 REGISTRATION: SPECIMEN SUBMISSION CRITERIA: Patients must be offered the opportunity to participate in translational medicine studies and specimen banking for future studies.
  • STEP 1 REGISTRATION: QUALITY OF LIFE CRITERIA: Patients who can complete Patient-Reported Outcome instruments in English, Spanish or French, must participate in the quality of life studies.
  • STEP 1 REGISTRATION: REGULATORY CRITERIA: Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.
  • STEP 2 RANDOMIZATION: DISEASE-RELATED CRITERIA: As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.
  • STEP 2 RANDOMIZATION: DISEASE-RELATED CRITERIA: Patients must have no evidence of disease progression during the 28 weeks of SST by PSA measure, bone scan and CT or MRI or symptomatic deterioration (as defined by physician discretion) within 28 days prior to randomization.
  • STEP 2 RANDOMIZATION: DISEASE-RELATED CRITERIA: Patients must have consultation with a urologist and have surgically resectable disease regardless of definitive treatment intent or randomization.
  • STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must have received between 22 and 28 weeks of SST as measured from the date of first hormonal therapy or surgical castration. SST is defined by current NCCN guidelines for metastatic prostate cancer.
  • STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must not be planning to receive docetaxel after randomization.
  • STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Any toxicities from SST must have resolved to =< grade 1 (Common Terminology Criteria for Adverse Events [CTCAE] version 5.0) prior to randomization.
  • STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients may have received elective metastasis directed therapy to oligometastatic sites (=< 4 sites). All treatment must be completed prior to randomization.
  • STEP 2 RANDOMIZATION: CLINICAL/LABORATORY CRITERIA: Patients must have a PSA performed within 28 days prior to randomization.
  • STEP 2 RANDOMIZATION: CLINICAL/LABORATORY CRITERIA: Patients must have a testosterone < 50 ng/dL within 28 days prior to randomization.
  • STEP 2 RANDOMIZATION: CLINICAL/LABORATORY CRITERIA: Patients must have a Zubrod performance status of 0 ? 1 within 28 days prior to randomization.

Who cannot join

None listed.

Trial locations and contacts

338 sites in 5 countries. Contact the study team or a site near you to ask about taking part.

Dana Sparks, MAT contact

2106148808 ext. 1004

dsparks@swog.org

304 sites in 5 countries

United States300 sites, 267 recruiting

  • Albany Medical Center

    Albany, New York, 12208

    Site Public Contact, 518-262-5513

    Badar M. Mian

    Recruiting

  • Atrium Health Stanly/LCI-Albemarle

    Albemarle, North Carolina, 28002

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • American Fork Hospital / Huntsman Intermountain Cancer Center

    American Fork, Utah, 84003

    Suspended

  • McFarland Clinic - Ames

    Ames, Iowa, 50010

    Site Public Contact, 515-239-4734, ksoder@mcfarlandclinic.com

    Joseph J. Merchant

    Recruiting

  • Saint Joseph Mercy Hospital

    Ann Arbor, Michigan, 48106

    Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org

    Christopher M. Reynolds

    Recruiting

  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan, 48109

    Site Public Contact, 800-865-1125

    Samuel D. Kaffenberger

    Recruiting

  • Langlade Hospital and Cancer Center

    Antigo, Wisconsin, 54409

    Site Public Contact, 715-623-9869, Juli.Alford@aspirus.org

    Christopher S. Platta

    Recruiting

  • Kaiser Permanente-Deer Valley Medical Center

    Antioch, California, 94531

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Mission Hospital

    Asheville, North Carolina, 28801

    Active, not recruiting

  • Grady Health System

    Atlanta, Georgia, 30303

    Site Public Contact, 404-489-9164

    Shreyas Joshi

    Recruiting

  • Emory University Hospital Midtown

    Atlanta, Georgia, 30308

    Site Public Contact, 888-946-7447

    Shreyas Joshi

    Recruiting

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia, 30322

    Site Public Contact, 404-778-1868

    Shreyas Joshi

    Recruiting

  • Emory Saint Joseph's Hospital

    Atlanta, Georgia, 30342

    Site Public Contact, 404-851-7115

    Shreyas Joshi

    Recruiting

  • Augusta University Medical Center

    Augusta, Georgia, 30912

    Site Public Contact, 706-721-2388, ga_cares@augusta.edu

    Sharad A. Ghamande

    Recruiting

  • University of Colorado Hospital

    Aurora, Colorado, 80045

    Site Public Contact, 720-848-0650

    Paul D. Maroni

    Recruiting

  • Rush - Copley Medical Center

    Aurora, Illinois, 60504

    Site Public Contact, 630-978-6212, Cancer.Research@rushcopley.com

    Sinisa Stanic

    Recruiting

  • Mount Sinai Comprehensive Cancer Center at Aventura

    Aventura, Florida, 33180

    Site Public Contact, 305-674-2625, yenrique@msmc.com

    Michael A. Schwartz

    Recruiting

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287

    Active, not recruiting

  • MaineHealth Coastal Cancer Treatment Center

    Bath, Maine, 04530

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Matthew H. Hayn

    Recruiting

  • Nebraska Medicine-Bellevue

    Bellevue, Nebraska, 68123

    Site Public Contact, 402-559-6941, unmcrsa@unmc.edu

    Benjamin A. Teply

    Recruiting

  • FHCC Overlake

    Bellevue, Washington, 98004

    Site Public Contact, 425-454-2148

    Jason Comer

    Recruiting

  • Central Vermont Medical Center/National Life Cancer Treatment

    Berlin Corners, Vermont, 05602

    Site Public Contact, 802-225-5400

    Nataniel H. Lester-Coll

    Recruiting

  • Billings Clinic Cancer Center

    Billings, Montana, 59101

    Site Public Contact, 800-996-2663, research@billingsclinic.org

    John M. Schallenkamp

    Recruiting

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois, 61704

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Prisma Health Cancer Institute - Spartanburg

    Boiling Springs, South Carolina, 29316

    Site Public Contact, 864-241-6251

    Ki Y. Chung

    Recruiting

  • Rocky Mountain Cancer Centers-Boulder

    Boulder, Colorado, 80304

    Site Public Contact, 303-777-2663, info@westernstatesncorp.org

    Nicholas DiBella

    Recruiting

  • Bozeman Deaconess Hospital

    Bozeman, Montana, 59715

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Lafayette Family Cancer Center-EMMC

    Brewer, Maine, 04412

    Site Public Contact, 800-987-3005

    Sarah J. Sinclair

    Recruiting

  • Saint Joseph Mercy Brighton

    Brighton, Michigan, 48114

    Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org

    Christopher M. Reynolds

    Recruiting

  • Henry Ford Cancer Institute-Downriver

    Brownstown, Michigan, 48183

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Haythem Y. Ali

    Recruiting

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263

    Site Public Contact, 800-767-9355, askroswell@roswellpark.org

    Gurkamal S. Chatta

    Recruiting

  • Lahey Hospital and Medical Center

    Burlington, Massachusetts, 01805

    Active, not recruiting

  • University of Vermont Medical Center

    Burlington, Vermont, 05401

    Site Public Contact, 802-656-4101, rpo@uvm.edu

    Nataniel H. Lester-Coll

    Recruiting

  • Saint James Community Hospital and Cancer Treatment Center

    Butte, Montana, 59701

    Site Public Contact, 406-723-2621

    Troy A. Fiddler

    Recruiting

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho, 83605

    Site Public Contact, 734-712-3671, stephanie.couch@stjoeshealth.org

    John M. Schallenkamp

    Recruiting

  • Illinois CancerCare-Canton

    Canton, Illinois, 61520

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Saint Joseph Mercy Canton

    Canton, Michigan, 48188

    Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org

    Christopher M. Reynolds

    Recruiting

  • Cleveland Clinic Mercy Hospital

    Canton, Ohio, 44708

    Site Public Contact, 888-293-4673

    Mitchell Haut

    Recruiting

  • Saint Francis Medical Center

    Cape Girardeau, Missouri, 63703

    Site Public Contact, 573-334-2230, sfmc@sfmc.net

    Bryan A. Faller

    Recruiting

  • Southeast Cancer Center

    Cape Girardeau, Missouri, 63703

    Site Public Contact, 573-651-5550

    Bryan A. Faller

    Recruiting

  • Illinois CancerCare-Carthage

    Carthage, Illinois, 62321

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Sandra L Maxwell Cancer Center

    Cedar City, Utah, 84720

    Suspended

  • Miami Valley Hospital South

    Centerville, Ohio, 45459

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Tarek M. Sabagh

    Recruiting

  • Chambersburg Hospital

    Chambersburg, Pennsylvania, 17201

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Sherif F. Yacoub

    Recruiting

  • Medical University of South Carolina

    Charleston, South Carolina, 29425

    Site Public Contact, 843-792-9321, hcc-clinical-trials@musc.edu

    David T. Marshall

    Recruiting

  • Carolinas Medical Center/Levine Cancer Institute

    Charlotte, North Carolina, 28203

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • Atrium Health Pineville/LCI-Pineville

    Charlotte, North Carolina, 28210

    Site Public Contact, 980-442-2000

    Earle F. Burgess

    Recruiting

  • Atrium Health University City/LCI-University

    Charlotte, North Carolina, 28262

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • Levine Cancer Institute-Ballantyne

    Charlotte, North Carolina, 28277

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • Saint Joseph Mercy Chelsea

    Chelsea, Michigan, 48118

    Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org

    Christopher M. Reynolds

    Recruiting

  • Northwestern University

    Chicago, Illinois, 60611

    Active, not recruiting

  • Rush University Medical Center

    Chicago, Illinois, 60612

    Site Public Contact, 312-942-5498, clinical_trials@rush.edu

    Srinivas Vourganti

    Recruiting

  • University of Illinois

    Chicago, Illinois, 60612

    Site Public Contact, 312-355-3046

    Daniel Moreira

    Recruiting

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, 60637

    Active, not recruiting

  • University of Cincinnati Cancer Center-UC Medical Center

    Cincinnati, Ohio, 45219

    Site Public Contact, 513-584-7698, cancer@uchealth.com

    Abhinav Sidana

    Recruiting

  • Siteman Cancer Center at Saint Peters Hospital

    City of Saint Peters, Missouri, 63376

    Site Public Contact, 800-600-3606, info@siteman.wustl.edu

    Jeff M. Michalski

    Recruiting

  • GenesisCare USA - Clarkston

    Clarkston, Michigan, 48346

    Site Public Contact, 941-833-5700, Rudi.Ross@usa.genesiscare.com

    Frank A. Vicini

    Recruiting

  • MetroHealth Medical Center

    Cleveland, Ohio, 44109

    Site Public Contact, 216-778-8526, dstrater@metrohealth.org

    William Tse

    Recruiting

  • Henry Ford Macomb Hospital-Clinton Township

    Clinton Township, Michigan, 48038

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Haythem Y. Ali

    Recruiting

  • Community Cancer Institute

    Clovis, California, 93611

    Site Public Contact, 559-387-1827

    Uzair B. Chaudhary

    Recruiting

  • University Oncology Associates

    Clovis, California, 93611

    Suspended

  • UCHealth Memorial Hospital Central

    Colorado Springs, Colorado, 80909

    Site Public Contact, 719-365-2406

    Paul D. Maroni

    Recruiting

  • Memorial Hospital North

    Colorado Springs, Colorado, 80920

    Site Public Contact, 719-364-6700

    Paul D. Maroni

    Recruiting

  • University of Missouri - Ellis Fischel

    Columbia, Missouri, 65212

    Site Public Contact, 573-882-7440

    Kushal Naha

    Recruiting

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210

    Site Public Contact, 800-293-5066, Jamesline@osumc.edu

    Steven K. Clinton

    Recruiting

  • New Hampshire Oncology Hematology PA-Concord

    Concord, New Hampshire, 03301

    Site Public Contact, 603-224-2556

    Douglas J. Weckstein

    Recruiting

  • Atrium Health Cabarrus/LCI-Concord

    Concord, North Carolina, 28025

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • MD Anderson in The Woodlands

    Conroe, Texas, 77384

    Site Public Contact, 866-632-6789, askmdanderson@mdanderson.org

    Brian F. Chapin

    Recruiting

  • Mercy Hospital

    Coon Rapids, Minnesota, 55433

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Coral Gables

    Coral Gables, Florida, 33146

    Site Public Contact, 305-243-2647

    Chad R. Ritch

    Recruiting

  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri, 63141

    Site Public Contact, 800-600-3606, info@siteman.wustl.edu

    Jeff M. Michalski

    Recruiting

  • Parkland Memorial Hospital

    Dallas, Texas, 75235

    Site Public Contact, 214-590-5582, canceranswerline@UTSouthwestern.edu

    Suzanne M. Cole

    Recruiting

  • UT Southwestern Simmons Cancer Center - RedBird

    Dallas, Texas, 75237

    Site Public Contact, 214-648-7097, canceranswerline@utsouthwestern.edu

    Suzanne M. Cole

    Recruiting

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390

    Site Public Contact, 214-648-7097, canceranswerline@UTSouthwestern.edu

    Suzanne M. Cole

    Recruiting

  • Noyes Memorial Hospital/Myers Cancer Center

    Dansville, New York, 14437

    Site Public Contact, WCICTOresearch@urmc.rochester.edu

    Paul M. Barr

    Recruiting

  • Geisinger Medical Center

    Danville, Pennsylvania, 17822

    Site Public Contact, 570-271-5251, HemonCCTrials@geisinger.edu

    Ahmad Hanif

    Recruiting

  • Miami Valley Hospital North

    Dayton, Ohio, 45415

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Tarek M. Sabagh

    Recruiting

  • Atlanta VA Medical Center

    Decatur, Georgia, 30033

    Site Public Contact, 404-321-6111 ext. 7632

    Wayne B. Harris

    Recruiting

  • Decatur Memorial Hospital

    Decatur, Illinois, 62526

    Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com

    Bryan A. Faller

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach

    Deerfield Beach, Florida, 33442

    Site Public Contact, 305-243-2647

    Chad R. Ritch

    Recruiting

  • Porter Adventist Hospital

    Denver, Colorado, 80210

    Site Public Contact, 719-776-6550, ResearchTracking@Centura.Org

    Shahzad Siddique

    Recruiting

  • Iowa Methodist Medical Center

    Des Moines, Iowa, 50309

    Site Public Contact, 515-241-6727

    Joshua Lukenbill

    Recruiting

  • Wayne State University/Karmanos Cancer Institute

    Detroit, Michigan, 48201

    Site Public Contact, 313-576-9790, ctoadmin@karmanos.org

    Elisabeth I. Heath

    Recruiting

  • Henry Ford Hospital

    Detroit, Michigan, 48202

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Haythem Y. Ali

    Recruiting

  • Wentworth-Douglass Hospital

    Dover, New Hampshire, 03820

    Active, not recruiting

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010

    Site Public Contact, 800-826-4673, becomingapatient@coh.org

    Tanya B. Dorff

    Recruiting

  • Kaiser Permanente Dublin

    Dublin, California, 94568

    Site Public Contact, 877-642-4691

    Andrea L. Harzstark

    Recruiting

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin, 54701

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Seth O. Fagbemi

    Recruiting

  • Fairview Southdale Hospital

    Edina, Minnesota, 55435

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Shaw Cancer Center

    Edwards, Colorado, 81632

    Site Public Contact, 970-569-7429

    Patricia H. Hardenbergh

    Recruiting

  • Crossroads Cancer Center

    Effingham, Illinois, 62401

    Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com

    Bryan A. Faller

    Recruiting

  • Ephrata Cancer Center

    Ephrata, Pennsylvania, 17522

    Site Public Contact, 717-721-4840

    Sherif F. Yacoub

    Recruiting

  • Illinois CancerCare-Eureka

    Eureka, Illinois, 61530

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • GenesisCare USA - Farmington Hills

    Farmington Hills, Michigan, 48334

    Site Public Contact, 941-833-5700, Rudi.Ross@usa.genesiscare.com

    Frank A. Vicini

    Recruiting

  • Poudre Valley Hospital

    Fort Collins, Colorado, 80524

    Site Public Contact, 970-297-6150

    Paul D. Maroni

    Recruiting

  • UT Southwestern/Simmons Cancer Center-Fort Worth

    Fort Worth, Texas, 76104

    Site Public Contact, 214-648-7097, canceranswerline@UTSouthwestern.edu

    Suzanne M. Cole

    Recruiting

  • Kaiser Permanente-Fremont

    Fremont, California, 94538

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Fresno Cancer Center

    Fresno, California, 93720

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Kaiser Permanente-Fresno

    Fresno, California, 93720

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Unity Hospital

    Fridley, Minnesota, 55432

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Illinois CancerCare-Galesburg

    Galesburg, Illinois, 61401

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Levine Cancer Institute-Gaston

    Gastonia, North Carolina, 28054

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • Adams Cancer Center

    Gettysburg, Pennsylvania, 17325

    Site Public Contact, 877-441-7957

    Sherif F. Yacoub

    Recruiting

  • Banner MD Anderson Cancer Center

    Gilbert, Arizona, 85234

    Site Public Contact, 602-747-9738

    Chinedu Mmeje

    Recruiting

  • Glens Falls Hospital

    Glens Falls, New York, 12801

    Site Public Contact, 518-926-6700

    Nataniel H. Lester-Coll

    Recruiting

  • Spectrum Health at Butterworth Campus

    Grand Rapids, Michigan, 49503

    Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

    Kathleen J. Yost

    Recruiting

  • Benefis Healthcare- Sletten Cancer Institute

    Great Falls, Montana, 59405

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • North Colorado Medical Center

    Greeley, Colorado, 80631

    Site Public Contact, 970-810-3046, BMDACCResearchCOMailbox@bannerhealth.com

    Supriya Jain

    Recruiting

  • Prisma Health Cancer Institute - Faris

    Greenville, South Carolina, 29605

    Site Public Contact, 864-241-6251

    Ki Y. Chung

    Recruiting

  • Saint Francis Cancer Center

    Greenville, South Carolina, 29607

    Site Public Contact, 864-603-6213, melissa_beckman@bshsi.org

    Jennifer Vogel

    Recruiting

  • Prisma Health Cancer Institute - Eastside

    Greenville, South Carolina, 29615

    Site Public Contact, 864-241-6251

    Ki Y. Chung

    Recruiting

  • Prisma Health Cancer Institute - Greer

    Greer, South Carolina, 29650

    Site Public Contact, 864-241-6251

    Ki Y. Chung

    Recruiting

  • Legacy Mount Hood Medical Center

    Gresham, Oregon, 97030

    Active, not recruiting

  • Smilow Cancer Hospital Care Center - Guilford

    Guilford, Connecticut, 06437

    Site Public Contact, 203-785-5702, canceranswers@yale.edu

    Preston C. Sprenkle

    Recruiting

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601

    Site Public Contact, 201-996-2879

    Robert S. Alter

    Recruiting

  • Comprehensive Cancer Centers of Nevada - Henderson

    Henderson, Nevada, 89052

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Margaret R Pardee Memorial Hospital

    Hendersonville, North Carolina, 28791

    Site Public Contact, 828-696-4716, pardeecancerresearch@unchealth.unc.edu

    Praveen Vashist

    Recruiting

  • Lyndon Baines Johnson General Hospital

    Houston, Texas, 77026-1967

    Site Public Contact, 713-566-5000

    Brian F. Chapin

    Recruiting

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas, 77030

    Site Public Contact, 713-798-1354, burton@bcm.edu

    Martha P. Mims

    Recruiting

  • Ben Taub General Hospital

    Houston, Texas, 77030

    Site Public Contact, 713-873-2000

    Martha P. Mims

    Recruiting

  • Houston Methodist Hospital

    Houston, Texas, 77030

    Active, not recruiting

  • M D Anderson Cancer Center

    Houston, Texas, 77030

    Site Public Contact, 877-632-6789, askmdanderson@mdanderson.org

    Brian F. Chapin

    Recruiting

  • Michael E DeBakey VA Medical Center

    Houston, Texas, 77030

    Site Public Contact, 800-553-2278

    Aihua E. Yen

    Recruiting

  • MD Anderson West Houston

    Houston, Texas, 77079

    Site Public Contact, 877-632-6789, askmdanderson@mdanderson.org

    Brian F. Chapin

    Recruiting

  • Indiana University/Melvin and Bren Simon Cancer Center

    Indianapolis, Indiana, 46202

    Active, not recruiting

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa, 52242

    Site Public Contact, 800-237-1225

    Yousef Zakharia

    Recruiting

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216

    Suspended

  • Baptist MD Anderson Cancer Center

    Jacksonville, Florida, 32207

    Site Public Contact, 904-202-7468

    Jonathan J. Melquist

    Recruiting

  • Freeman Health System

    Joplin, Missouri, 64804

    Site Public Contact, 417-347-4030, LJCrockett@freemanhealth.com

    Jay W. Carlson

    Recruiting

  • West Michigan Cancer Center

    Kalamazoo, Michigan, 49007

    Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

    Kathleen J. Yost

    Recruiting

  • Kalispell Regional Medical Center

    Kalispell, Montana, 59901

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • University of Kansas Cancer Center

    Kansas City, Kansas, 66160

    Site Public Contact, 913-588-3671, KUCC_Navigation@kumc.edu

    William Parker

    Recruiting

  • University of Kansas Cancer Center - North

    Kansas City, Missouri, 64154

    Site Public Contact, 913-588-3671, KUCC_Navigation@kumc.edu

    William Parker

    Recruiting

  • Greater Dayton Cancer Center

    Kettering, Ohio, 45409

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Howard M. Gross

    Recruiting

  • Kettering Medical Center

    Kettering, Ohio, 45429

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Howard M. Gross

    Recruiting

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois, 61443

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Seattle Cancer Care Alliance at EvergreenHealth

    Kirkland, Washington, 98034

    Site Public Contact, 425-899-6000

    Eric W. Dean

    Recruiting

  • Mayo Clinic Health System-Franciscan Healthcare

    La Crosse, Wisconsin, 54601

    Active, not recruiting

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92093

    Site Public Contact, 858-822-5354, cancercto@ucsd.edu

    Aditya Bagrodia

    Recruiting

  • Northwell Health/Center for Advanced Medicine

    Lake Success, New York, 11042

    Active, not recruiting

  • Sparrow Hospital

    Lansing, Michigan, 48912

    Site Public Contact, 517-364-9400

    Christopher M. Reynolds

    Recruiting

  • Radiation Oncology Centers of Nevada Central

    Las Vegas, Nevada, 89106

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Comprehensive Cancer Centers of Nevada - Northwest

    Las Vegas, Nevada, 89128

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Comprehensive Cancer Centers of Nevada-Summerlin

    Las Vegas, Nevada, 89144

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada, 89148

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Comprehensive Cancer Centers of Nevada - Central Valley

    Las Vegas, Nevada, 89169

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • MD Anderson League City

    League City, Texas, 77573

    Site Public Contact, 877-632-6789, askmdanderson@mdanderson.org

    Brian F. Chapin

    Recruiting

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire, 03756

    Site Public Contact, 800-639-6918, cancer.research.nurse@dartmouth.edu

    Rodwell Mabaera

    Recruiting

  • Sechler Family Cancer Center

    Lebanon, Pennsylvania, 17042

    Site Public Contact, 717-741-8303, doxenberg@wellspan.org

    Sherif F. Yacoub

    Recruiting

  • Geisinger Medical Oncology-Lewisburg

    Lewisburg, Pennsylvania, 17837

    Site Public Contact, 570-374-8555, HemonCCTrials@geisinger.edu

    Ahmad Hanif

    Recruiting

  • Saint Joseph Radiation Oncology Resource Center

    Lexington, Kentucky, 40504

    Site Public Contact, 859-629-7169, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Saint Joseph Hospital East

    Lexington, Kentucky, 40509

    Site Public Contact, 859-629-7169, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536

    Site Public Contact, 859-257-3379

    Patrick J. Hensley

    Not yet recruiting

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205

    Site Public Contact, 501-686-8274

    Shi-Ming Tu

    Recruiting

  • Littleton Adventist Hospital

    Littleton, Colorado, 80122

    Site Public Contact, 719-776-6550, ResearchTracking@Centura.Org

    Shahzad Siddique

    Recruiting

  • Logan Regional Hospital

    Logan, Utah, 84321

    Suspended

  • Tibor Rubin VA Medical Center

    Long Beach, California, 90822

    Site Public Contact, 562-826-8000

    Greg Gin

    Recruiting

  • Los Angeles County-USC Medical Center

    Los Angeles, California, 90033

    Site Public Contact, 323-865-0451

    Siamak Daneshmand

    Recruiting

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California, 90033

    Site Public Contact, 323-865-0451

    Siamak Daneshmand

    Recruiting

  • The James Graham Brown Cancer Center at University of Louisville

    Louisville, Kentucky, 40202

    Site Public Contact, 502-562-3429

    Scott R. Silva

    Recruiting

  • McKee Medical Center

    Loveland, Colorado, 80539

    Site Public Contact, 970-810-3046, BMDACCResearchCOMailbox@bannerhealth.com

    Supriya Jain

    Recruiting

  • Illinois CancerCare-Macomb

    Macomb, Illinois, 61455

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • GenesisCare USA - Macomb

    Macomb, Michigan, 48044

    Site Public Contact, 941-833-5700, Rudi.Ross@usa.genesiscare.com

    Frank A. Vicini

    Recruiting

  • GenesisCare USA - Madison Heights

    Madison Heights, Michigan, 48071

    Site Public Contact, 941-833-5700, Rudi.Ross@usa.genesiscare.com

    Frank A. Vicini

    Recruiting

  • Elliot Hospital

    Manchester, New Hampshire, 03103

    Active, not recruiting

  • Solinsky Center for Cancer Care

    Manchester, New Hampshire, 03103

    Site Public Contact, 800-339-6484

    Douglas J. Weckstein

    Recruiting

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin, 54449

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Seth O. Fagbemi

    Recruiting

  • Fremont - Rideout Cancer Center

    Marysville, California, 95901

    Site Public Contact, 530-749-4400

    Richard K. Valicenti

    Recruiting

  • Loyola University Medical Center

    Maywood, Illinois, 60153

    Site Public Contact, 708-226-4357

    Ami Badami

    Recruiting

  • Froedtert Menomonee Falls Hospital

    Menomonee Falls, Wisconsin, 53051

    Site Public Contact, 262-257-5100

    Scott Johnson

    Recruiting

  • East Jefferson General Hospital

    Metairie, Louisiana, 70006

    Site Public Contact, 504-210-3539, emede1@lsuhsc.edu

    Scott E. Delacroix

    Recruiting

  • LSU Healthcare Network / Metairie Multi-Specialty Clinic

    Metairie, Louisiana, 70006

    Site Public Contact, 504-210-3539, emede1@lsuhsc.edu

    Scott E. Delacroix

    Recruiting

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, 33136

    Site Public Contact, 305-243-2647

    Chad R. Ritch

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Kendall

    Miami, Florida, 33176

    Site Public Contact, 305-243-2647

    Chad R. Ritch

    Recruiting

  • Mount Sinai Medical Center

    Miami Beach, Florida, 33140

    Site Public Contact, 305-674-2625, yenrique@msmc.com

    Michael A. Schwartz

    Recruiting

  • Bon Secours Saint Francis Medical Center

    Midlothian, Virginia, 23114

    Site Public Contact, 804-893-8978, anne_carmellat@bshsi.org

    William J. Irvin

    Recruiting

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226

    Site Public Contact, 414-805-3666

    Scott Johnson

    Recruiting

  • Zablocki Veterans Administration Medical Center

    Milwaukee, Wisconsin, 53295

    Site Public Contact, 888-469-6614

    Elizabeth M. Gore

    Recruiting

  • Hennepin County Medical Center

    Minneapolis, Minnesota, 55415

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Health Partners Inc

    Minneapolis, Minnesota, 55454

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Marshfield Clinic-Minocqua Center

    Minocqua, Wisconsin, 54548

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Seth O. Fagbemi

    Recruiting

  • Kaiser Permanente-Modesto

    Modesto, California, 95356

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Atrium Health Union/LCI-Union

    Monroe, North Carolina, 28112

    Site Public Contact, 980-442-2000

    Earle F. Burgess

    Recruiting

  • West Virginia University Healthcare

    Morgantown, West Virginia, 26506

    Site Public Contact, 304-293-7374, cancertrialsinfo@hsc.wvu.edu

    Danh C. Pham

    Recruiting

  • Intermountain Medical Center

    Murray, Utah, 84107

    Suspended

  • Carolina Regional Cancer Center

    Myrtle Beach, South Carolina, 29577

    Site Public Contact, 877-460-2657

    Frank A. Vicini

    Recruiting

  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, Idaho, 83687

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232

    Site Public Contact, 800-811-8480

    Kerry R. Schaffer

    Recruiting

  • CarolinaEast Medical Center

    New Bern, North Carolina, 28561

    Site Public Contact, 252-634-6589, lharrison@carolinaeasthealth.com

    Sarah B. Carroll

    Recruiting

  • Yale University

    New Haven, Connecticut, 06520

    Site Public Contact, 203-785-5702, canceranswers@yale.edu

    Preston C. Sprenkle

    Recruiting

  • Cancer Center of Western Wisconsin

    New Richmond, Wisconsin, 54017

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • NYP/Weill Cornell Medical Center

    New York, New York, 10065

    Site Public Contact, 212-746-1848

    Douglas Scherr

    Recruiting

  • Helen F Graham Cancer Center

    Newark, Delaware, 19713

    Site Public Contact, 302-623-4450, lbarone@christianacare.org

    Gregory A. Masters

    Recruiting

  • Christiana Care Health System-Christiana Hospital

    Newark, Delaware, 19718

    Site Public Contact, 302-623-4450, lbarone@christianacare.org

    Gregory A. Masters

    Recruiting

  • Drexel Town Square Health Center

    Oak Creek, Wisconsin, 53154

    Site Public Contact, 414-805-0505

    Scott Johnson

    Recruiting

  • Kaiser Permanente Oakland-Broadway

    Oakland, California, 94611

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Kaiser Permanente-Oakland

    Oakland, California, 94611

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • McKay-Dee Hospital Center

    Ogden, Utah, 84403

    Suspended

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104

    Site Public Contact, 405-271-8777, ou-clinical-trials@ouhsc.edu

    Kelly L. Stratton

    Recruiting

  • Olathe Health Cancer Center

    Olathe, Kansas, 66061

    Site Public Contact, 913-355-8000, Jeni.wakefield@olathehealth.org

    William Parker

    Recruiting

  • Nebraska Methodist Hospital

    Omaha, Nebraska, 68114

    Site Public Contact, 402-354-5144

    Ralph J. Hauke

    Recruiting

  • Nebraska Medicine-Village Pointe

    Omaha, Nebraska, 68118

    Site Public Contact, 402-559-5600

    Benjamin A. Teply

    Recruiting

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198

    Site Public Contact, 402-559-6941, unmcrsa@unmc.edu

    Benjamin A. Teply

    Recruiting

  • Upstate Cancer Center Radiation Oncology at Oneida

    Oneida, New York, 13421

    Site Public Contact, 315-464-3603, BinghamE@upstate.edu

    Gennady Bratslavsky

    Recruiting

  • Orlando Health Cancer Institute

    Orlando, Florida, 32806

    Active, not recruiting

  • Upstate Cancer Center Radiation Oncology at Oswego

    Oswego, New York, 13126

    Site Public Contact, 315-464-3603, BinghamE@upstate.edu

    Gennady Bratslavsky

    Recruiting

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois, 61350

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • University of Kansas Cancer Center-Overland Park

    Overland Park, Kansas, 66210

    Site Public Contact, 913-588-3671, KUCC_Navigation@kumc.edu

    William Parker

    Recruiting

  • Desert Regional Medical Center

    Palm Springs, California, 92262

    Site Public Contact, 760-416-4730

    Amir Lavaf

    Recruiting

  • Stanford Cancer Institute Palo Alto

    Palo Alto, California, 94304

    Site Public Contact, 650-498-7061, ccto-office@stanford.edu

    Geoffrey A. Sonn

    Recruiting

  • Parker Adventist Hospital

    Parker, Colorado, 80138

    Site Public Contact, 719-776-6550, ResearchTracking@Centura.Org

    Shahzad Siddique

    Recruiting

  • Illinois CancerCare-Pekin

    Pekin, Illinois, 61554

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Illinois CancerCare-Peoria

    Peoria, Illinois, 61615

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Methodist Medical Center of Illinois

    Peoria, Illinois, 61636

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • OSF Saint Francis Medical Center

    Peoria, Illinois, 61637

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Illinois CancerCare-Peru

    Peru, Illinois, 61354

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Temple University Hospital

    Philadelphia, Pennsylvania, 19140

    Withdrawn

  • Cancer Center at Saint Joseph's

    Phoenix, Arizona, 85004

    Site Public Contact, 602-406-0777, CancerInstitute@DignityHealth.org

    Shahzad Siddique

    Recruiting

  • Mayo Clinic Hospital in Arizona

    Phoenix, Arizona, 85054

    Suspended

  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania, 15232

    Site Public Contact, 412-647-8073

    Benjamin J. Davies

    Recruiting

  • UPMC-Shadyside Hospital

    Pittsburgh, Pennsylvania, 15232

    Site Public Contact, 412-621-2334

    Benjamin J. Davies

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Plantation

    Plantation, Florida, 33324

    Site Public Contact, 305-243-2647

    Chad R. Ritch

    Recruiting

  • 21st Century Oncology-Pontiac

    Pontiac, Michigan, 48341

    Site Public Contact, 734-712-3671, stephanie.couch@stjoeshealth.org

    Christopher M. Reynolds

    Recruiting

  • Maine Medical Center-Bramhall Campus

    Portland, Maine, 04102

    Site Public Contact, 207-885-7565

    Matthew H. Hayn

    Recruiting

  • Legacy Good Samaritan Hospital and Medical Center

    Portland, Oregon, 97210

    Active, not recruiting

  • Oregon Health and Science University

    Portland, Oregon, 97239

    Active, not recruiting

  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, Idaho, 83854

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Illinois CancerCare-Princeton

    Princeton, Illinois, 61356

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Utah Valley Regional Medical Center

    Provo, Utah, 84604

    Suspended

  • Kaiser Permanente-Rancho Cordova Cancer Center

    Rancho Cordova, California, 95670

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Kaiser Permanente-Redwood City

    Redwood City, California, 94063

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Marshfield Medical Center-Rice Lake

    Rice Lake, Wisconsin, 54868

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Seth O. Fagbemi

    Recruiting

  • UT Southwestern Clinical Center at Richardson/Plano

    Richardson, Texas, 75080

    Site Public Contact, 972-669-7044, Suzanne.cole@utsouthwestern.edu

    Suzanne M. Cole

    Recruiting

  • Kaiser Permanente-Richmond

    Richmond, California, 94801

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Reid Health

    Richmond, Indiana, 47374

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Howard M. Gross

    Recruiting

  • Bon Secours Cancer Institute at Reynolds Crossing

    Richmond, Virginia, 23230

    Site Public Contact, 804-893-8978, Anne_caramella@bshsi.org

    William J. Irvin

    Recruiting

  • VCU Massey Cancer Center at Stony Point

    Richmond, Virginia, 23235

    Site Public Contact, ctoclinops@vcu.edu

    Asit K. Paul

    Recruiting

  • Virginia Commonwealth University/Massey Cancer Center

    Richmond, Virginia, 23298

    Site Public Contact, CTOclinops@vcu.edu

    Asit K. Paul

    Recruiting

  • Riverton Hospital

    Riverton, Utah, 84065

    Suspended

  • North Memorial Medical Health Center

    Robbinsdale, Minnesota, 55422

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905

    Suspended

  • Highland Hospital

    Rochester, New York, 14620

    Site Public Contact, 585-341-8113

    Paul M. Barr

    Recruiting

  • University of Rochester

    Rochester, New York, 14642

    Site Public Contact, 585-275-5830

    Paul M. Barr

    Recruiting

  • Rock Hill Radiation Therapy Center

    Rock Hill, South Carolina, 29730

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • Levine Cancer Institute-Rock Hill

    Rock Hill, South Carolina, 29732

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • Rohnert Park Cancer Center

    Rohnert Park, California, 94928

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Delbert Day Cancer Institute at PCRMC

    Rolla, Missouri, 65401

    Site Public Contact, 573-458-7504, research@phelpshealth.org

    Jay W. Carlson

    Recruiting

  • Kaiser Permanente-Roseville

    Roseville, California, 95661

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • The Permanente Medical Group-Roseville Radiation Oncology

    Roseville, California, 95678

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Kaiser Permanente Downtown Commons

    Sacramento, California, 95814

    Site Public Contact, 877-642-4691, kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Mercy Cancer Center - Sacramento

    Sacramento, California, 95816

    Site Public Contact, 916-556-3301, OncologyResearch@DignityHealth.org

    Shahzad Siddique

    Recruiting

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817

    Site Public Contact, 916-734-3089

    Richard K. Valicenti

    Recruiting

  • Kaiser Permanente-South Sacramento

    Sacramento, California, 95823

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • South Sacramento Cancer Center

    Sacramento, California, 95823

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Ascension Saint Mary's Hospital

    Saginaw, Michigan, 48601

    Site Public Contact, 989-907-8411, lori.srebinski@ascension.org

    Christopher M. Reynolds

    Recruiting

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota, 55416

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Regions Hospital

    Saint Paul, Minnesota, 55101

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri, 63670

    Site Public Contact, 314-996-5569

    Bryan A. Faller

    Recruiting

  • University of Utah Sugarhouse Health Center

    Salt Lake City, Utah, 84106

    Site Public Contact, 888-424-2100, cancerinfo@hci.utah.edu

    Alejandro Sanchez

    Recruiting

  • Utah Cancer Specialists-Salt Lake City

    Salt Lake City, Utah, 84106

    Suspended

  • Huntsman Cancer Institute/University of Utah

    Salt Lake City, Utah, 84112

    Site Public Contact, 888-424-2100, cancerinfo@hci.utah.edu

    Alejandro Sanchez

    Recruiting

  • LDS Hospital

    Salt Lake City, Utah, 84143

    Suspended

  • George E Wahlen Department of Veterans Affairs Medical Center

    Salt Lake City, Utah, 84148

    Site Public Contact, 801-582-1565

    Sumati V. Gupta

    Recruiting

  • Audie L Murphy VA Hospital

    San Antonio, Texas, 78229

    Site Public Contact, 877-469-5300

    Michael A. Liss

    Recruiting

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas, 78229

    Active, not recruiting

  • Kaiser Permanente-San Francisco

    San Francisco, California, 94115

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Kaiser Permanente-Santa Teresa-San Jose

    San Jose, California, 95119

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Kaiser Permanente San Leandro

    San Leandro, California, 94577

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Pacific Central Coast Health Center-San Luis Obispo

    San Luis Obispo, California, 93401

    Site Public Contact, 805-219-4673, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Kaiser San Rafael-Gallinas

    San Rafael, California, 94903

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • MaineHealth Cancer Care Center of York County

    Sanford, Maine, 04073

    Site Public Contact, 207-459-1600

    Matthew H. Hayn

    Recruiting

  • MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford

    Sanford, Maine, 04073

    Site Public Contact, LLemire@mmc.org

    Matthew H. Hayn

    Recruiting

  • Kaiser Permanente Medical Center - Santa Clara

    Santa Clara, California, 95051

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Kaiser Permanente-Santa Rosa

    Santa Rosa, California, 95403

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Maine Medical Center- Scarborough Campus

    Scarborough, Maine, 04074

    Site Public Contact, 207-396-8090, wrighd@mmc.org

    Matthew H. Hayn

    Recruiting

  • Mayo Clinic in Arizona

    Scottsdale, Arizona, 85259

    Suspended

  • FHCC South Lake Union

    Seattle, Washington, 98109

    Site Public Contact, 800-804-8824

    Daniel W. Lin

    Recruiting

  • FHCC at Northwest Hospital

    Seattle, Washington, 98133

    Site Public Contact, 206-606-5800

    Nikhil V. Kamat

    Recruiting

  • University of Washington Medical Center - Montlake

    Seattle, Washington, 98195

    Site Public Contact, 800-804-8824

    Daniel W. Lin

    Recruiting

  • Prisma Health Cancer Institute - Seneca

    Seneca, South Carolina, 29672

    Site Public Contact, 864-241-6251

    Ki Y. Chung

    Recruiting

  • Saint Francis Regional Medical Center

    Shakopee, Minnesota, 55379

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • VCU Community Memorial Health Center

    South Hill, Virginia, 23970

    Site Public Contact, nemer.elmouallem@vcuhealth.org

    Asit K. Paul

    Recruiting

  • Kaiser Permanente Cancer Treatment Center

    South San Francisco, California, 94080

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Kaiser Permanente-South San Francisco

    South San Francisco, California, 94080

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Mercy Hospital Springfield

    Springfield, Missouri, 65804

    Site Public Contact, 417-269-4520

    Jay W. Carlson

    Recruiting

  • CoxHealth South Hospital

    Springfield, Missouri, 65807

    Site Public Contact, 417-269-4520

    Jay W. Carlson

    Recruiting

  • Washington University School of Medicine

    St Louis, Missouri, 63110

    Site Public Contact, 800-600-3606, info@siteman.wustl.edu

    Jeff M. Michalski

    Recruiting

  • Siteman Cancer Center-South County

    St Louis, Missouri, 63129

    Site Public Contact, 800-600-3606, info@siteman.wustl.edu

    Jeff M. Michalski

    Recruiting

  • Missouri Baptist Medical Center

    St Louis, Missouri, 63131

    Site Public Contact, 314-996-5569

    Bryan A. Faller

    Recruiting

  • Siteman Cancer Center at Christian Hospital

    St Louis, Missouri, 63136

    Site Public Contact, 800-600-3606, info@siteman.wustl.edu

    Jeff M. Michalski

    Recruiting

  • Mercy Hospital Saint Louis

    St Louis, Missouri, 63141

    Site Public Contact, 314-251-7066

    Jay W. Carlson

    Recruiting

  • Saint George Regional Medical Center

    St. George, Utah, 84770

    Suspended

  • Stamford Hospital/Bennett Cancer Center

    Stamford, Connecticut, 06904

    Site Public Contact, 203-323-8944

    Anthony P. Gulati

    Recruiting

  • Ascension Saint Michael's Hospital

    Stevens Point, Wisconsin, 54481

    Site Public Contact, 715-847-2353, Beth.Knetter@aspirus.org

    Christopher S. Platta

    Recruiting

  • Marshfield Medical Center-River Region at Stevens Point

    Stevens Point, Wisconsin, 54482

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Seth O. Fagbemi

    Recruiting

  • Kaiser Permanente-Stockton

    Stockton, California, 95210

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Andrea L. Harzstark

    Recruiting

  • Stony Brook University Medical Center

    Stony Brook, New York, 11794

    Site Public Contact, 800-862-2215

    Massimiliano Spaliviero

    Recruiting

  • MD Anderson in Sugar Land

    Sugar Land, Texas, 77478

    Site Public Contact, 877-632-6789, askmdanderson@mdanderson.org

    Brian F. Chapin

    Recruiting

  • Southwest Illinois Health Services LLP

    Swansea, Illinois, 62226

    Suspended

  • ProMedica Flower Hospital

    Sylvania, Ohio, 43560

    Site Public Contact, 419-824-1842, PCIOncResearch@promedica.org

    Jeffrey A. Forquer

    Recruiting

Other trials in United States

Chile1 site, 1 recruiting

  • Instituto Nacional del Cancer

    Independence, 8380455

    Site Public Contact, info@incancer.cl

    Annerleim Walton-diaz

    Recruiting

Other trials in Chile

Colombia1 site, 1 recruiting

  • Instituto Nacional De Cancerologia

    Bogotá, 99999

    Site Public Contact, 57 1 3341111

    Marino Cabrera

    Recruiting

Other trials in Colombia

Mexico1 site, 1 recruiting

  • Instituto Nacional De Cancerologia de Mexico

    Mexico City, Tlalpan, 14080

    Site Public Contact, (52) 5628-0400

    Miguel A. Jimenez-Rios

    Recruiting

Other trials in Mexico

Switzerland1 site, 1 recruiting

  • Kantonsspital Aarau

    Aarau, 5001

    Site Public Contact, 41 62 838 60 50

    Oliver Riesterer

    Recruiting

Other trials in Switzerland

About this study

Official title: Phase III Randomized Trial of Standard Systemic Therapy (SST) Versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer

This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or spreading.

Read the detailed description

PRIMARY OBJECTIVES:

  1. To compare overall survival in metastatic prostate cancer patients who are randomized to standard systemic therapy (SST) plus definitive treatment of the primary tumor versus standard systemic therapy alone.

SECONDARY OBJECTIVES:

  1. To compare overall survival in metastatic prostate cancer patients who received SST plus surgical excision of the primary tumor versus SST alone in the subset who specify the surgical intent stratification factor.

II. To compare the rate of symptomatic local progression between the treatment arms.

III. To compare progression-free survival (PFS) between the two treatment arms. IV. To compare rates of progression-free survival between arms for the subsets of patients with and without metastasis directed therapy (MDT) to oligometastatic sites.

QUALITY OF LIFE OBJECTIVES:

  1. To compare between arms patient-reported urinary function and urinary bother over time (after initiation of SST at 6 months, 1, 2, and 3 years) using the Expanded Prostate Cancer Index Composite (EPIC) and patient-reported pain and physical functioning using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) between patients receiving standard systemic therapy and those receiving systemic therapy and definitive management of the primary prostate cancer.

OTHER OBJECTIVES:

  1. To bank tissue and whole blood specimens for future use.

OUTLINE:

INDUCTION: Participants receive 1 of 6 acceptable forms of SST for 22-28 weeks. I. Participants undergo a bilateral orchiectomy. II. Participants receive goserelin acetate subcutaneously (SC) every 28 days or 12 weeks, histrelin acetate SC every 12 months, leuprolide acetate SC or intramuscularly (IM) every 1, 3, 4, or 6 months, and triptorelin every 1, 3, or 6 months.

III. Participants receive goserelin acetate SC every 28 days or 12 weeks, histrelin acetate SC every 12 months, leuprolide acetate SC or IM every 1, 3, 4, or 6 months, and triptorelin every 1, 3, or 6 months. Participants also receive nilutamide orally (PO) daily, flutamide PO every 8 hours, and bicalutamide PO daily.

IV. Participants receive degarelix via injection for 2 doses and then every 28 days.

  1. Participants receive nilutamide PO daily, flutamide PO every 8 hours, and bicalutamide PO daily. Participants also receive docetaxel over 1 hour every 3 weeks with or without prednisone PO every 12 hours.

VI. Participants receive nilutamide PO daily, flutamide PO every 8 hours, and bicalutamide PO daily. Participants also receive abiraterone PO daily or prednisone PO every 12 hours.

After completion of 22-28 weeks of SST, participants are then randomized to 1 of 2 arms.

ARM I: Participants receive 1 acceptable form of SST as in Induction except for treatment with docetaxel and prednisone.

ARM II: Participants receive 1 acceptable form of SST as in Induction except for treatment with docetaxel and prednisone. Participants undergo prostatectomy within 8 weeks after randomization or radiation therapy within 4 weeks of randomization.

After completion of study treatment, participants are followed up for 8 years.

Being tested
Abiraterone, Bicalutamide, Degarelix, Docetaxel, Flutamide
Medical subject headings
Prostatic Neoplasms

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • AbirateroneDrug

    Also called CB 7598

    Given PO

  • BicalutamideDrug

    Also called Casodex, Cosudex, ICI 176,334, ICI 176334

    Given PO

  • DegarelixDrug

    Also called FE200486, Firmagon

    Given via injection

  • DocetaxelDrug

    Also called Docecad, RP56976, Taxotere, Taxotere Injection Concentrate

    intravenous

  • FlutamideDrug

    Also called 4'-Nitro-3'-trifluoromethylisobutyranilide, Apimid, Cebatrol, Chimax

    Given PO

  • Goserelin AcetateDrug

    Also called ZDX, Zoladex

    Given SC

  • Histrelin AcetateDrug

    Also called Supprelin, Vantas

    Receive SC

  • Leuprolide AcetateDrug

    Also called A-43818, Abbott 43818, Abbott-43818, Carcinil

    Receive SC or IM

  • NilutamideDrug

    Also called Anandron, Nilandron, RU-23908

    Given PO

  • OrchiectomyProcedure or surgery

    Also called Castration, Male Castration, Male Gonadectomy, orchidectomy

    Undergo bilateral orchiectomy

  • PrednisoneDrug

    Also called .delta.1-Cortisone, 1, 2-Dehydrocortisone, Adasone, Cortancyl

    Given PO

  • Quality-of-Life AssessmentOther

    Also called Quality of Life Assessment

    Ancillary studies

  • Radiation TherapyRadiation

    Also called Cancer Radiotherapy, Irradiate, Irradiated, irradiation

    Standard radiation

  • Radical ProstatectomyProcedure or surgery

    Also called Prostatovesiculectomy

    Standard surgery

  • TriptorelinDrug

    Also called 6-D-Tryptophan-LH-RH, 6-D-Tryptophanluteinizing Hormone-releasing Factor, AY-25650, CL-118,532

    injection

Study groups in NCT03678025
Study groupRoleWhat they receive
Arm I (SST)Active comparatorParticipants receive 1 acceptable form of SST as in Induction except for treatment with docetaxel and prednisone.
Receives: Drug: Abiraterone; Drug: Bicalutamide; Drug: Degarelix; Drug: Flutamide; Drug: Goserelin Acetate; Drug: Histrelin Acetate; Drug: Leuprolide Acetate; Drug: Nilutamide; Procedure: Orchiectomy; Other: Quality-of-Life Assessment; Drug: Triptorelin
Arm II (SST, prostatectomy or radiation therapy)ExperimentalParticipants receive 1 acceptable form of SST as in Induction except for treatment with docetaxel and prednisone. Participants undergo prostatectomy within 8 weeks after randomization or radiation therapy within 4 weeks of randomization.
Receives: Drug: Abiraterone; Drug: Bicalutamide; Drug: Degarelix; Drug: Flutamide; Drug: Goserelin Acetate; Drug: Histrelin Acetate; Drug: Leuprolide Acetate; Drug: Nilutamide; Procedure: Orchiectomy; Other: Quality-of-Life Assessment; Radiation: Radiation Therapy; Procedure: Radical Prostatectomy; Drug: Triptorelin
Step 1 (pre-randomization)Active comparatorStandard treatment data collection prior to randomization
Receives: Drug: Abiraterone; Drug: Bicalutamide; Drug: Degarelix; Drug: Docetaxel; Drug: Flutamide; Drug: Goserelin Acetate; Drug: Histrelin Acetate; Drug: Leuprolide Acetate; Drug: Nilutamide; Procedure: Orchiectomy; Drug: Prednisone; Other: Quality-of-Life Assessment; Drug: Triptorelin

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Overall survival (OS)

    Measured: From date of randomization to date of death due to any cause, assessed up to 8 years

Secondary outcomes (3)

  1. Media OS

    Will compare OS in metastatic prostate cancer patients who received standard systemic therapy (SST) plus surgical excision of the primary tumor versus SST alone in the subset who specify the surgical intent stratification factor.

    Measured: From date of randomization to date of death due to any cause, assessed up to 8 years

  2. Rate of symptomatic local progression

    Defined as any of the following events post-randomization: Common Terminology Criteria for Adverse Events version 5 grade >= 2 hematuria, urinary retention, urinary tract obstruction, urinary tract pain, pelvic pain, renal and urinary disorders-other. Will be compared between the treatment arms. A proportional hazards model will be fit to each of these endpoints where the time interval starts at date of randomization to (i) time of first symptomatic local progression or ii) progression or death due to any cause, where those without the event are censored at their last contact date. Stratification factors will be adjusted for as covariates.

    Measured: Up to 8 years

  3. Progression-free survival (PFS)

    Will be compared between for the subsets of patients with and without metastasis directed therapy (MDT) to oligometastatic sites. A proportional hazards model will be fit to each of these endpoints where the time interval starts at date of randomization to (i) time of first symptomatic local progression or ii) progression or death due to any cause, where those without the event are censored at their last contact date. Stratification factors will be adjusted for as covariates.

    Measured: From date of randomization to date of first documentation of progression, or death due to any cause, assessed up to 8 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted19 Sep 2018
  2. Study start24 Sep 2018
  3. Primary completion1 Apr 2033 (estimated)
  4. Study completion1 Oct 2036 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
1,273 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT03678025
Sponsor's protocol ID
S1802
Other IDs
NCI-2018-01738, S1802, S1802, U10CA180888
Status last verified
Oct 2026
First submitted
18 Sep 2018
Last updated
8 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
Yes

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Abiraterone, Bicalutamide and Degarelix in people with Castration Levels of Testosterone and Metastatic Prostatic Adenocarcinoma, run by SWOG Cancer Research Network at 338 sites in 5 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 24 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 8 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 338 sites in United States, Chile, Colombia, Mexico, Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Dana Sparks, MAT (2106148808 ext. 1004, dsparks@swog.org), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Overall survival (OS) (time frame: From date of randomization to date of death due to any cause, assessed up to 8 years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT03678025.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Oct 2026; AzTrials last refreshed its copy on 26 Oct 2026.

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