Medial Meniscus, Posterior Horn DerangementNCT03632707
Magnetic Resonance Imaging of Medial Meniscal Posterior Root Tear
A study testing Magnetic Resonance Imaging of the knee and Knee Arthroscopy in people with Medial Meniscus, Posterior Horn Derangement, run by Assiut University at 1 site in Egypt.
Trial summary
The aim of this study is to evaluate and analyze the role of magnetic resonance imaging in the diagnosis of medial meniscal posterior root tears, including the normal variations in meniscal anatomy that may resemble a meniscal tear, and identifying the causes or nature of posterior medial meniscal root… Read more about this study
- Who is it for?
- Ages 16 years and older
- Conditions the study is for
- Medial Meniscus, Posterior Horn Derangement
- What is being tested?
- Magnetic Resonance Imaging of the knee and Knee Arthroscopy
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Feb 2019to 1 Feb 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Patients of either sex from more than 16 years, having acute or chronic painful knee associated with popping sounds are included in this study.
Who cannot join
- Patients who are contraindicated to Magnetic Resonance Imaging examination as those who have artificial cardiac pacemaker or metallic prosthesis not compatible with Magnetic Resonance Imaging or those with severe claustrophobia.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Role of Magnetic Resonance Imaging in the Diagnosis of Posterior Medial Meniscal Root Tear of the Knee
The aim of this study is to evaluate and analyze the role of magnetic resonance imaging in the diagnosis of medial meniscal posterior root tears, including the normal variations in meniscal anatomy that may resemble a meniscal tear, and identifying the causes or nature of posterior medial meniscal root tear(degenerative versus traumatic) and correlate the results with the standard reference knee Arthroscopy.In addition to identifying and estimating the suspected cases of meniscal extrusion by making MRI with stress varus overloading simulating weight bearing.
Read the detailed description
The knee joint is one of the most important joints in the human body responsible for weight-bearing and a group of complex movements during ordinary life activities and even in vigorous sports making it susceptible to different traumatic injuries.Knee pain is considered as one of the most common complaints of patients presenting to clinical practitioners.There are many structures within the knee which can cause pain. By far, one of the most common causes of knee pain is a meniscus tear.The meniscus is the most important cushion in the knee; It plays an important bio mechanical role in axial load distribution of the knees. If the meniscus is injured and the cushioning is lost, arthritis and pain can occur.Menisci can tear due to traumatic injury or degenerative wear, meniscal root tears are a type of meniscal tear in the knee where the tear extends to either the anterior or posterior meniscal root attachment to the central tibial plateau. They often tend to be radial tears extending into the root.The medial meniscal posterior root tear can occur especially in middle-aged or older patients who have a single event of posteromedial painful popping sensation during light activities.Magnetic resonance imaging is well established as the best imaging modality for evaluating a patient with suspected meniscal pathology, involving the medial meniscal posterior horn root.In recent years, posterior meniscal root tears have received increasing attention in both Arthroscopic and Magnetic resonance study. All sequences of Magnetic resonance imaging should be reviewed, but T2 weighted coronal sections should provide the best visualization of the posterior roots. The Magnetic resonance findings of a medial meniscal posterior radial root tear are shortening or absence of the root (ghost sign) on sagittal images and a vertical fluid cleft with truncation sign and features of meniscal extrusion on coronal images.
It is very important to avoid errors in diagnosing meniscal root tears. So interpreting Magnetic resonance examinations of the knee need to be aware of the attachments of the menisci and to understand the normal variations in meniscal anatomy that may resemble a meniscal tear.
Tears of the meniscal root are relatively uncommon, occurring in 2.2% - 9.8% of patients undergoing Magnetic resonance imaging of the knee.However, it is important that these tears be diagnosed as several complications of meniscal root tear, including meniscal extrusion, secondary osteoarthritis, and subchondral insufficiency fracture.
- Being tested
- Magnetic Resonance Imaging of the knee, Knee Arthroscopy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Magnetic Resonance Imaging of the kneeRadiation
After clinical assessment, all the patients will examined by Magnetic Resonance Imaging to diagnose the medial meniscal posterior root tear,and the suspected cases of meniscal extrusion will make MRI using the knee coil for varus stress Overloading simulating weight bearing
Knee ArthroscopyProcedure or surgery
Correlate all the magnetic resonance imaging results with the Knee Arthroscopy
| Study group | Role | What they receive |
|---|---|---|
| Magnetic resonance imaging of the knee | Other | Patients complain of painful knee with clinical suspicious of medial meniscus posterior root tear of the knee will be examined by all Magnetic Resonance Imaging sequences including sagittal, coronal and axial PD,T2 and PD-SPIR weighted images, and correlate the results with Knee Arthroscopy.while the suspected cases of meniscal extrusion will make MRI using the knee coil for varus stress Overloading simulating weight bearing. Receives: Radiation: Magnetic Resonance Imaging of the knee; Procedure: Knee Arthroscopy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Patients complain of painful knee joint associated with popping sounds and clinically suspected of medial meniscal posterior root tear will examined by Magnetic Resonance Imaging
Correlation the results of Magnetic Resonance Imaging with gold standard knee Arthroscopy.
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Aug 2018
- Study start1 Feb 2019
- Primary completion1 Jan 2022
- Study completion1 Feb 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Medial Meniscus, Posterior Horn DerangementStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, AAQardash, Assiut University
- Investigators
- Nisreen A. Abbas, MD, Study director, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03632707
- Sponsor's protocol ID
- MRIOMMPRT
- Status last verified
- Jan 2022
- First submitted
- 13 Aug 2018
- Last updated
- 17 Feb 2022
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Barile A, Conti L, Lanni G, Calvisi V, Masciocchi C. Evaluation of medial meniscus tears and meniscal stability: weight-bearing MRI vs arthroscopy. Eur J Radiol. 2013 Apr;82(4):633-9. doi: 10.1016/j.ejrad.2012.10.018. Epub 2012 Nov 28.
PubMed 23199751Park HJ, Kim SS, Lee SY, Choi YJ, Chung EC, Rho MH, Kwag HJ. Medial meniscal root tears and meniscal extrusion transverse length ratios on MRI. Br J Radiol. 2012 Nov;85(1019):e1032-7. doi: 10.1259/bjr/26261821.
PubMed 23091292Carreau JH, Sitton SE, Bollier M. Medial Meniscus Root Tear in the Middle Aged Patient: A Case Based Review. Iowa Orthop J. 2017;37:123-132.
PubMed 28852346Costa CR, Morrison WB, Carrino JA. Medial meniscus extrusion on knee MRI: is extent associated with severity of degeneration or type of tear? AJR Am J Roentgenol. 2004 Jul;183(1):17-23. doi: 10.2214/ajr.183.1.1830017.
PubMed 15208101
Study at a glance
From the registry record, last updated by the sponsor on 17 Feb 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Role of Magnetic Resonance Imaging in the Diagnosis of Posterior Medial Meniscal Root Tear of the Knee
- ClinicalTrials.gov ID
- NCT03632707
- Acronym / sponsor ID
- MRIOMMPRT
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Feb 2019 (actual)
- Primary completion
- 1 Jan 2022 (actual)
- Study completion
- 1 Feb 2022 (actual)
- First posted
- 15 Aug 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to evaluate and analyze the role of magnetic resonance imaging in the diagnosis of medial meniscal posterior root tears, including the normal variations in meniscal anatomy that may resemble a meniscal tear, and identifying the causes or nature of posterior medial meniscal root tear(degenerative versus traumatic) and correlate the results with the standard reference knee Arthroscopy.In addition to identifying and estimating the suspected cases of meniscal extrusion by making MRI with stress varus overloading simulating weight bearing.
Detailed description
The knee joint is one of the most important joints in the human body responsible for weight-bearing and a group of complex movements during ordinary life activities and even in vigorous sports making it susceptible to different traumatic injuries.Knee pain is considered as one of the most common complaints of patients presenting to clinical practitioners.There are many structures within the knee which can cause pain. By far, one of the most common causes of knee pain is a meniscus tear.The meniscus is the most important cushion in the knee; It plays an important bio mechanical role in axial load distribution of the knees. If the meniscus is injured and the cushioning is lost, arthritis and pain can occur.Menisci can tear due to traumatic injury or degenerative wear, meniscal root tears are a type of meniscal tear in the knee where the tear extends to either the anterior or posterior meniscal root attachment to the central tibial plateau. They often tend to be radial tears extending into the root.The medial meniscal posterior root tear can occur especially in middle-aged or older patients who have a single event of posteromedial painful popping sensation during light activities.Magnetic resonance imaging is well established as the best imaging modality for evaluating a patient with suspected meniscal pathology, involving the medial meniscal posterior horn root.In recent years, posterior meniscal root tears have received increasing attention in both Arthroscopic and Magnetic resonance study. All sequences of Magnetic resonance imaging should be reviewed, but T2 weighted coronal sections should provide the best visualization of the posterior roots. The Magnetic resonance findings of a medial meniscal posterior radial root tear are shortening or absence of the root (ghost sign) on sagittal images and a vertical fluid cleft with truncation sign and features of meniscal extrusion on coronal images.
It is very important to avoid errors in diagnosing meniscal root tears. So interpreting Magnetic resonance examinations of the knee need to be aware of the attachments of the menisci and to understand the normal variations in meniscal anatomy that may resemble a meniscal tear.
Tears of the meniscal root are relatively uncommon, occurring in 2.2% - 9.8% of patients undergoing Magnetic resonance imaging of the knee.However, it is important that these tears be diagnosed as several complications of meniscal root tear, including meniscal extrusion, secondary osteoarthritis, and subchondral insufficiency fracture.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Magnetic resonance imaging of the knee | Other | Radiation: Magnetic Resonance Imaging of the knee, Procedure: Knee ArthroscopyPatients complain of painful knee with clinical suspicious of medial meniscus posterior root tear of the knee will be examined by all Magnetic Resonance Imaging sequences including sagittal, coronal and axial PD,T2 and PD-SPIR weighted images, and correlate the results with Knee Arthroscopy.while the suspected cases of meniscal extrusion will make MRI using the knee coil for varus stress Overloading simulating weight bearing. |
Who may qualify
- Ages
- 16 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (1 listed)
- Patients of either sex from more than 16 years, having acute or chronic painful knee associated with popping sounds are included in this study.
Key exclusion criteria (1 listed)
- Patients who are contraindicated to Magnetic Resonance Imaging examination as those who have artificial cardiac pacemaker or metallic prosthesis not compatible with Magnetic Resonance Imaging or those with severe claustrophobia.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Magnetic Resonance Imaging of the kneeAfter clinical assessment, all the patients will examined by Magnetic Resonance Imaging to diagnose the medial meniscal posterior root tear,and the suspected cases of meniscal extrusion will make MRI using the knee coil for varus stress Overloading simulating weight bearing | Radiation | Magnetic resonance imaging of the knee |
| Knee ArthroscopyCorrelate all the magnetic resonance imaging results with the Knee Arthroscopy | Procedure or surgery | Magnetic resonance imaging of the knee |
Primary outcome
Patients complain of painful knee joint associated with popping sounds and clinically suspected of medial meniscal posterior root tear will examined by Magnetic Resonance Imaging
Time frame: 6 months
Correlation the results of Magnetic Resonance Imaging with gold standard knee Arthroscopy.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Feb 2022.
- Background: PubMed 23199751Barile A, Conti L, Lanni G, Calvisi V, Masciocchi C. Evaluation of medial meniscus tears and meniscal stability: weight-bearing MRI vs arthroscopy. Eur J Radiol. 2013 Apr;82(4):633-9. doi: 10.1016/j.ejrad.2012.10.018. Epub 2012 Nov 28.
- Results publication: PubMed 23091292Park HJ, Kim SS, Lee SY, Choi YJ, Chung EC, Rho MH, Kwag HJ. Medial meniscal root tears and meniscal extrusion transverse length ratios on MRI. Br J Radiol. 2012 Nov;85(1019):e1032-7. doi: 10.1259/bjr/26261821.
- Results publication: PubMed 28852346Carreau JH, Sitton SE, Bollier M. Medial Meniscus Root Tear in the Middle Aged Patient: A Case Based Review. Iowa Orthop J. 2017;37:123-132.
- Results publication: PubMed 15208101Costa CR, Morrison WB, Carrino JA. Medial meniscus extrusion on knee MRI: is extent associated with severity of degeneration or type of tear? AJR Am J Roentgenol. 2004 Jul;183(1):17-23. doi: 10.2214/ajr.183.1.1830017.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Nisreen A. Abbas, MD study director
Assiut University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Magnetic Resonance Imaging of the knee and Knee Arthroscopy in people with Medial Meniscus, Posterior Horn Derangement, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Feb 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Patients complain of painful knee joint associated with popping sounds and clinically suspected of medial meniscal posterior root tear will examined by Magnetic Resonance Imaging (time frame: 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03632707, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Feb 2022.