Acute Coronary SyndromePhase 3AEGIS-IINCT03473223
Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome
A Phase 3 study testing Apolipoprotein A-I [human] (apoA-I) in people with Acute Coronary Syndrome, run by CSL Behring at 903 sites in 49 countries.
Trial summary
This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke] in subjects with acute coronary syndrome (ACS)… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Coronary Syndrome
- What is being tested?
- Apolipoprotein A-I [human] (apoA-I)
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 18,226 participants
- Where
- 903 sitesin 49 countries
- Study dates
- 21 Mar 2018to 17 Nov 2023
- Phase
- Phase 3
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Male or female least 18 years of age
- Evidence of myocardial necrosis, consistent with type I (spontaneous) MI
- No suspicion of acute kidney injury
- Evidence of multivessel coronary artery disease
- Presence of established cardiovascular risk factor(s):
- Diabetes mellitus on pharmacotherapy OR
- 2 or more of the following: age ≥ 65 years, prior history of MI, peripheral arterial disease
Who cannot join
- Ongoing hemodynamic instability
- Evidence of hepatobiliary disease
- Evidence of severe chronic kidney disease
- Plan to undergo scheduled coronary artery bypass graft surgery as treatment for the index MI
- Known history of allergies, hypersensitivity, or deficiencies to soy bean, peanut or albumin
Trial locations and contacts
903 sites in 49 countries.
903 sites in 49 countries
United States202 sites
8401042 - Abington Medical Specialists
Abington, Pennsylvania, 19001
8400657 - Summa Health
Akron, Ohio, 44304
8400896 - Advanced Cardiovascular LLC
Alexander City, Alabama, 35010
8400368 - Cambridge Medical Trials
Alexandria, Louisiana, 71301
8400595 - Lehigh Valley Hospital
Allentown, Pennsylvania, 18103
8400805 - PharmaTex Research
Amarillo, Texas, 79016
8400482 - Amarillo Heart Clinical Research Institute
Amarillo, Texas, 79106
8400618 - McFarland Clinic, PC
Ames, Iowa, 50010
8400591 - AnMed Health Medical Center
Anderson, South Carolina, 29621
8401142 - Anne Arundel Health System
Annapolis, Maryland, 21401
8401185 - Piedmont Heart Institute
Athens, Georgia, 30606
8400376 - Emory University
Atlanta, Georgia, 30322-1059
8400918 - Augusta University
Augusta, Georgia, 30912
8400574 - Aurora Denver Cardiology Associates
Aurora, Colorado, 80012
8401054 - Central Cardiology Medical Center
Bakersfield, California, 93308
8400483 - Eastern Maine Medical Center
Bangor, Maine, 04401
8400350 - Cardiology, PC
Birmingham, Alabama, 35211
8400357 - Saint Luke's Boise Medical Center
Boise, Idaho, 83712
8400998 - Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215
8400545 - Advanced Heart Care LLC
Bridgewater, New Jersey, 08807
8400360 - Buffalo Heart Group
Buffalo, New York, 14215
8401028 - Buffalo V.A. Medical Center
Buffalo, New York, 14215
8400835 - Cooper University Hospital
Camden, New Jersey, 08103
8400836 - Our Lady of Lourdes Medical Center
Camden, New Jersey, 08103
8400608 - Holy Spirit Cardiology
Camp Hill, Pennsylvania, 17001
8400793 - Aultman Hospital
Canton, Ohio, 44710
8400872 - Chambersburg Hospital
Chambersburg, Pennsylvania, 17201
8401027 - UNC Hospitals Heart and Vascular Center at Meadowmont
Chapel Hill, North Carolina, 27517
8400733 - Novant Health Heart and Vascular Institute
Charlotte, North Carolina, 28204
8400854 - The Chattanooga Heart Institute
Chattanooga, Tennessee, 37404
8400610 - Jesse Brown V.A. Medical Center
Chicago, Illinois, 60612
8400858 - University of Cincinnati
Cincinnati, Ohio, 45219
8401233 - Cincinnati V.A. Medical Center
Cincinnati, Ohio, 45220
8400484 - Clearwater Cardiovascular and Interventional Consultants
Clearwater, Florida, 33756
8400966 - MetroHealth System
Cleveland, Ohio, 44109
8400684 - UCHealth Memorial Hospital Central - Colorado Springs
Colorado Springs, Colorado, 80909
8401108 - University of Missouri Health System
Columbia, Missouri, 65212
8400849 - IACT Health
Columbus, Georgia, 31904
8400379 - John Muir Health and Cardiovascular Institute
Concord, California, 94520
8400931 - Valley Clinical Trials
Covina, California, 91723
8400862 - Cardiovascular Associates Research
Covington, Louisiana, 70433
8400485 - V.A. North Texas Health Care System
Dallas, Texas, 75216
8400371 - Danbury Hospital
Danbury, Connecticut, 06810
8400565 - Miami Valley Hospital
Dayton, Ohio, 45409
8400544 - Cardiology Research Associates
Daytona Beach, Florida, 32117
8400655 - Atlanta V.A. Medical Center
Decatur, Georgia, 30033
8400577 - Doylestown Cardiology Associates
Doylestown, Pennsylvania, 18901
8400488 - Essentia Health
Duluth, Minnesota, 55805
8400920 - Saint Lukes Hospital
Duluth, Minnesota, 55805
8400489 - Duke University Hospital
Durham, North Carolina, 27710
8400361 - Midwest Cardiovascular Research
Elkhart, Indiana, 46514
8400654 - North Ohio Research Ltd.
Elyria, Ohio, 44035
8400930 - Lake Internal Medicine Assoc.
Eustis, Florida, 32726
8401093 - Advanced Heart Care Group
Fairview Heights, Illinois, 62208
8401064 - Inova Fairfax Hospital
Falls Church, Virginia, 22042-3300
8400651 - Sanford Medical Center Fargo
Fargo, North Dakota, 58122
8400613 - Jim Moran Heart and Vascular Center
Fort Lauderdale, Florida, 33308
8401010 - Integrative Research Associates Inc.
Fort Lauderdale, Florida, 33312
8400911 - Brooke Army Medical Center
Fort Sam Houston, Texas, 78234-6200
8401103 - Orange Coast Memorial Hospital
Fountain Valley, California, 92708
8400490 - University of Florida
Gainesville, Florida, 32610
8401120 - Northeast Georgia Medical Center
Gainesville, Georgia, 30501
8400556 - Mercy Gilbert Medical Center
Gilbert, Arizona, 85297
8400769 - Healthy Heart Cardiology
Grandville, Michigan, 49418
8400997 - CardioVascular Institute of North Colorado Cardiology Clinic
Greeley, Colorado, 80631
8400491 - Moses H. Cone Memorial Hospital
Greensboro, North Carolina, 27401-1020
8401171 - Greenville Hospital System
Greenville, South Carolina, 29605
8401055 - Upstate Cardiology, PA
Greenville, South Carolina, 29607
8400496 - Advanced Cardiology Associates
Greenwood, South Carolina, 29646
8400324 - Milton Hershey Medical Center
Hershey, Pennsylvania, 17033
8400366 - High Point Regional Hospital
High Point, North Carolina, 27262
8401104 - Cardiovascular Institute of the South
Houma, Louisiana, 70361-4176
8400337 - Heart Center Research, LLC
Huntsville, Alabama, 35801
8400961 - Indiana Heart Physicians, Inc.
Indianapolis, Indiana, 46237
8400989 - Indiana Heart Hospital
Indianapolis, Indiana, 46250
8400507 - The Saint Vincent Heart Center of Indiana
Indianapolis, Indiana, 46290
8401168 - Jackson Heart Clinic
Jackson, Mississippi, 39216
8400517 - Shands Jacksonville Medical Center
Jacksonville, Florida, 32209
8400645 - NEA Baptist Clinic
Jonesboro, Arkansas, 72401
8401141 - Western Michigan University Homer Striker MD School of Medicine
Kalamazoo, Michigan, 49048
8400091 - Glacier View Cardiology
Kalispell, Montana, 59901
8400648 - Saint Luke's Cardiovascular Consultants
Kansas City, Missouri, 64111
8400500 - Tennova Health Care - Turkey Creek Medical Center
Knoxville, Tennessee, 37934
8401166 - Sharp Grossmont Hospital
La Mesa, California, 91942
8400563 - Cardiovascular Institute of the South
Lafayette, Louisiana, 70503
8401192 - South Orange County Surgical Medical Group
Laguna Hills, California, 92653
8400344 - Lancaster General Hospital
Lancaster, Pennsylvania, 17604
8400582 - Carolina Heart Specialists
Lancaster, South Carolina, 29720
8400689 - University Medical Center
Las Vegas, Nevada, 89102
8400783 - Nebraska Heart Institute
Lincoln, Nebraska, 68526
8400975 - Central Arkansas Veterans Healthcare System
Little Rock, Arkansas, 72205
8400677 - Saint Joseph's Hospital Cardiac Catheterization Associates
Liverpool, New York, 13088
8400596 - Long Beach Memorial Medical Center
Long Beach, California, 90806
8400910 - Cardiovascular Innovation and Research Center
Long Beach, California, 90813
8400597 - Los Alamitos Cardiovascular
Los Alamitos, California, 90720
8400693 - University of California Los Angeles
Los Angeles, California, 90038
8400717 - V.A. Greater Los Angeles Healthcare System
Los Angeles, California, 90073
8400661 - Norton Cardiovascular Associates
Louisville, Kentucky, 40205
8400670 - Medical Center of the Rockies
Loveland, Colorado, 80538
8400916 - Southeastern Cardiology & Cardiovascular Clinic
Lumberton, North Carolina, 28358
8400502 - Stroobants Cardiovascular Center
Lynchburg, Virginia, 24501
8400503 - The Heart and Vascular Center / Holy Family Memorial
Manitowoc, Wisconsin, 54220
8400887 - Matthews Medical Center
Matthews, North Carolina, 28105
8401231 - Revival Research Institute
McKinney, Texas, 75069
8400881 - North Texas Research Associates
McKinney, Texas, 75071
8400760 - V.A. Medical Center - Memphis
Memphis, Tennessee, 38104
8400873 - Baptist Clinical Research Institute
Memphis, Tennessee, 38120
8400985 - Optimus U Corp.
Miami, Florida, 33125
8400638 - Mid Michigan Regional Medical Center
Midland, Michigan, 48670
8400364 - Minneapolis Heart Institute Foundation
Minneapolis, Minnesota, 55401
8400682 - Trinity Medical Group
Minot, North Dakota, 58701
8400888 - Saint Jude Heritage Healthcare
Mission Viejo, California, 92691
8400713 - University of South Alabama College of Medicine
Mobile, Alabama, 36617
8400576 - IU Health Ball Memorial Hospital Physicians, Inc
Muncie, Indiana, 47303
8400801 - Centennial Medical Center
Nashville, Tennessee, 37203
8401178 - Jersey Shore University Medical Center Meridian Health
Neptune City, New Jersey, 07753
8400921 - Mission Research Institute, LLC
New Braunfels, Texas, 78130
8401127 - Tulane University Health Science Center
New Orleans, Louisiana, 70112
8400380 - Mount Sinai Medical Center
New York, New York, 10029
8401119 - Lenox Hill Hospital
New York, New York, 10075
8401134 - Christiana Hospital
Newark, Delaware, 19718
8401144 - Saint Michael's Medical Center
Newark, New Jersey, 07102
8400745 - Hoag Memorial Hospital Presbyterian
Newport Beach, California, 92663
8400631 - North Kansas City Hospital
North Kansas City, Missouri, 64116
8400658 - Valley Clinical Trials, Inc.
Northridge, California, 91325
8400735 - Parkway Cardiology Associates, PC
Oak Ridge, Tennessee, 37830
8400504 - Integris Baptist Medical Center
Oklahoma City, Oklahoma, 73112
8400936 - South Oklahoma Heart Research
Oklahoma City, Oklahoma, 73135
8400978 - Midwest Heart and Vascular
Overland Park, Kansas, 66209
8400543 - Cardiology Partners Research Institute
Palm Beach Gardens, Florida, 33410
8401000 - Advocate Lutheran General Hospital
Park Ridge, Illinois, 60068
8400720 - Valley Clinical Trials
Pasadena, California, 91105
8400542 - Cardiology Consultants
Pensacola, Florida, 32501
8400785 - OSF Multi-Specialty Group
Peoria, Illinois, 61614
8400746 - Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104
8400747 - Phoenix V.A. Health Care System
Phoenix, Arizona, 85012
8400772 - Mayo Clinic Arizona
Phoenix, Arizona, 85054
8400718 - V.A. Pittsburgh Healthcare System
Pittsburgh, Pennsylvania, 15240
8400572 - AtlantiCare Regional Medical Center
Pomona, New Jersey, 08240
8401092 - Saint Joseph Mercy Oakland
Pontiac, Michigan, 48341
8400812 - Maine Medical Center Bramhall Campus
Portland, Maine, 04102
8400551 - Cardiovascular Research of Knoxville
Powell, Tennessee, 37849
8400811 - Rhode Island Hospital
Providence, Rhode Island, 02903
8400628 - Multicare Health System
Puyallup, Washington, 98372
8400889 - NC Heart and Vascular Research
Raleigh, North Carolina, 27607
8400320 - Black Hills Cardiovascular Research
Rapid City, South Dakota, 57701
8400882 - Reid Health
Richmond, Indiana, 47374
8400601 - McGuire Research Institute
Richmond, Virginia, 23249
8400787 - Riverside Community Hospital
Riverside, California, 92501
8400861 - Ascension Providence Rochester Hospital
Rochester, Michigan, 48307
8401154 - Rochester General Hospital
Rochester, New York, 14621
8400847 - University of Rochester Medical Center-Strong Memorial Hospital
Rochester, New York, 14642
8400557 - Clearwater Cardiovascular and Interventional Consultants
Safety Harbor, Florida, 34695
8400372 - Covenant Medical Center
Saginaw, Michigan, 48602
8400667 - Michigan Cardiovascular Institute
Saginaw, Michigan, 48602
8400752 - Regions Hospital
Saint Paul, Minnesota, 55101
8400369 - HealthEast Saint Joseph's Hospital
Saint Paul, Minnesota, 55102
8400704 - South Texas CV Consultants
San Antonio, Texas, 78201
8400694 - University of California San Diego Medical Center
San Diego, California, 92103
8400703 - San Diego Cardiac Center
San Diego, California, 92123
8400719 - V.A. San Diego Health Care System
San Diego, California, 92161
8400632 - North Ohio Heart Center
Sandusky, Ohio, 44870
8400686 - Intercoastal Medical Group
Sarasota, Florida, 34239
8401157 - Memorial Health University Medical Center
Savannah, Georgia, 31404
8400570 - Advanced Cardiology Specialists
Scranton, Pennsylvania, 18508
8400863 - Swedish Medical Center - Providence Campus
Seattle, Washington, 98122
8400890 - Revival Research Institute, LLC
Sherman, Texas, 75092
8401175 - Overton Brooks V.A. Medical Center
Shreveport, Louisiana, 71101
8400622 - Mercy Medical Research Institute
Springfield, Missouri, 65807
8400840 - Washington University
St Louis, Missouri, 63110
8401176 - Methodist Sugar Land Hospital
Sugar Land, Texas, 77479
8401163 - Washington Adventist Hospital
Takoma Park, Maryland, 20912
8400736 - Pepin Heart Institute
Tampa, Florida, 33613
8400626 - Montefiore Medical Center - Albert Einstein College of Medicine
The Bronx, New York, 10461
8400636 - Jacobi Medical Center
The Bronx, New York, 10461
8400700 - Mercy Saint Vincent Medical Center
Toledo, Ohio, 43608
8401164 - University of Toledo Medical Center
Toledo, Ohio, 43614
8400996 - Southern Arizona V.A. Healthcare System
Tucson, Arizona, 85723
8400664 - Oklahoma Heart Institute
Tulsa, Oklahoma, 74104
8400334 - Cardiology Associates of North Mississippi
Tupelo, Mississippi, 38801
8400521 - CAET Research
Tyler, Texas, 75701
8400726 - Westchester Medical Center
Valhalla, New York, 10595
8400909 - Ventura Clinical Trials
Ventura, California, 93003
8401189 - Cardiovascular Associates of the Delaware Valley
Vineland, New Jersey, 08360
8401128 - Hillcrest Family Health Center
Waco, Texas, 76710-4023
8400891 - John Muir Medical Center Walnu
Walnut Creek, California, 94598
8401165 - Ascension Macomb-Oakland Hospital Warren Campus
Warren, Michigan, 48236
8400779 - MedStar Clinical Research Center
Washington D.C., District of Columbia, 20010
8400688 - George Washington University Medical Center
Washington D.C., District of Columbia, 20037
8400904 - Northeast Iowa Medical Education Foundation
Waterloo, Iowa, 50702
8400358 - Aspirus Research Institute
Wausau, Wisconsin, 54401
8401011 - Cardiology Partners Research Institute
Wellington, Florida, 33449
8400678 - The Iowa Clinic, PC
West Des Moines, Iowa, 50266
8400893 - Interventional Cardiology Medical Group
West Hills, California, 91307
8401179 - Reading Hospital
West Reading, Pennsylvania, 19611
8400742 - VMG Cardiology, Westwood
Westwood, New Jersey, 07675
8400515 - Wichita Falls Heart Clinic
Wichita Falls, Texas, 76301
8400794 - Geisinger Wyoming Valley
Wilkes-Barre, Pennsylvania, 18711
8400759 - Winchester Cardiology and Vascular Medicine
Winchester, Virginia, 22601
8400322 - Wake Forest University Health Sciences, Dept. of Cardiovascular Medicine
Winston-Salem, North Carolina, 27157
8400625 - Michigan Heart and Vascular Institute
Ypsilanti, Michigan, 48197
8400639 - Genesis Health Care System
Zanesville, Ohio, 43701
Brazil41 sites
0760087 - MK BC Pesquisa Clinica
Balneário Camboriú, 88331-085
0760056 - Hospital Felício Rocho
Belo Horizonte, 30110-068
0760068 - Gutierrez Cardiologia Clinica e Intervencionista Ltda.
Belo Horizonte, 30350-540
0760085 - Hospital Universitário São José (HUSJ)
Belo Horizonte, 30860-382
0760021 - Fundacao Hospitalar Sao Francisco de Assis
Belo Horizonte, 31110-580
0760059 - Hospital do Coração do Brasil
Brasília, 70390-903
0760038 - Instituto de Cardiologia do Distrito Federal (ICDF)
Brasília, 70658-700
0760057 - Centro de Cardiologia Clinica e Pesquisa Dra. Juliana Souza
Brasília, 70710-100
0760060 - Hospital Angelina Caron
Campina Grande do Sul, 83430-000
0760077 - Instituto de Pesquisa Clinica de Campinas
Campinas, 13060-080
0760035 - Loema - Instituto de Pesquisa Clinica
Campinas, 13060-400
0760034 - Hospital e Maternidade Celso Pierro
Campinas, 13060-904
0760061 - Hospital Universitario Maria Aparecida Pedrossian
Campo Grande, 79080-090
0760036 - Hospital Geral Universitário de Cuiabá - HGU
Cuiabá, 78025-000
0760069 - Hospital Universitario Evangelico de Curitiba
Curitiba, Paraná, 80730-150
0760011 - Hospital Cardiologico Costantini
Curitiba, 80320-320
0760037 - Hospital de Messejana Dr. Carlos Alberto Gomes Studart
Fortaleza, 60840-285
0760009 - Santa Casa de Misericordia de Marilia
Marília, 17515-000
0760058 - Hospital São Vicente de Paulo
Passo Fundo, 99010-080
0760040 - Santa Casa de Misericordia de Pelotas
Pelotas, 96015-290
0760019 - Hospital São Lucas da PUCRS
Porto Alegre, 90610-000
0760012 - Instituto de Cardiologia do Rio Grande do Sul
Porto Alegre, 90620-001
0760015 - Hospital de Clínicas de Porto
Porto Alegre, 90620-050
0760052 - Hospital Nossa Senhora da Conceicao (HNSC)
Porto Alegre, 91350-200
0760018 - Pronto Socorro Cardiológico de Pernambuco (PROCAPE)
Recife, 50100-060
0760062 - Hospital Agamenon Magalhães
Recife, 52051-380
0760075 - Instituto D'Or de Pesquisa e Ensino
Rio de Janeiro, 22281-100
0760025 - Hospital Santa Izabel
Salvador, 40050-410
0760055 - Instituto Cardio Pulmonar da Bahia - Hospital
Salvador, 40170-130
0760053 - Fundação Bahiana de Cardiologia
Salvador, 41810-010
0760044 - Hospital da Bahia
Salvador, 41810-011
0760041 - Hospital e Maternidade Dr. Christovao da Gama
Santo André, 09030-010
0760027 - CEMEC - Centro Multidisciplinar de Estudos Clínicos
São Bernardo do Campo, 09780-000
0760047 - Instituto de Cardiologia de Santa Catarina (ICSC)
São José, 88103-450
0760016 - Faculdade de Medicina de Sao Jose do Rio Preto-SP - Hospital
São José do Rio Preto, 15090-000
0760083 - Irmandade da Santa Casa de Misericordia de Sao Paulo
São Paulo, 01221-020
0760031 - Instituto do Coração (InCor)
São Paulo, 05403-900
0760010 - Eurolatino Medical Research
Uberlândia, 38411-186
0760039 - Hospital Evangelico de Vila Velha (HEVV)
Vila Velha, 19460
0760081 - Hospital Universitário Cassiano Antonio Moraes (HUCAM)
Vitória, 29060-220
0760028 - Santa Casa de Votuporanga
Votuporanga, 15500-003
Japan38 sites
3920130 - Eiyukai Ayase Heart Hospital
Adachi-Ku, 120-0006
3920106 - Hyogo Prefectural Amagasaki General Medical Center
Amagasaki-Shi, 660-0828
3920095 - Showa University Fujigaoka Hospital
Aoba-Ku, 227-8501
3920156 - Asahi General Hospital
Asahi-Shi, 289-2511
3920122 - Sakakibara Heart Institute
Fuchu-Shi, 183-0003
3920105 - Fukuoka University Hospital
Fukuoka, 814-0180
3920101 - Teikyo University Hospital
Itabashi-Ku, 173-0003
3920116 - Nihon University Itabashi Hospital
Itabashi-Ku, 173-8610
3920094 - Juntendo University Shizuoka Hospital
Izunokuni-Shi, 410-2211
3920111 - Ishikawa Prefectural Central Hospital
Kanazawa, 920-8530
3920108 - Fukuoka Tokushukai Hospital
Kasuga-Shi, Kasuga-Shi
3920134 - Kimitsu Chuo Hospital
Kisarazu-Shi, 292-0822
3920092 - Chikamori Hospital
Kochi, 780-8522
3920109 - National Hospital Organization Kumamoto Medical Center
Kumamoto, 860-0008
3920113 - Kumamoto University Hospital
Kumamoto, 860-8556
3920100 - Saiseikai Kumamoto Hospital
Kumamoto, 861-4101
3920154 - Kurashiki Central Hospital
Kurashiki-shi, Okayama-ken, 710-8602
3920110 - Kurume University Hospital
Kurume-Shi, 830-0011
3920136 - Shin Koga Hospital
Kurume-Shi, 830-8577
3920103 - Kusatsu General Hospital
Kusatsu-Shi, 525-0066
3920115 - Matsusaka Chuo General Hospital
Matsusaka-Shi, 515-8566
3920119 - Ehime Prefectural Central Hospital
Matsuyama, 790-0024
3920114 - Toho University Ohashi Medical Center
Meguro-ku, 1538515
3920093 - Miyazaki Medical Association Hospital
Miyazaki, 880-0834
3920107 - Teine Keijinkai Hospital
Sapporo, 006-0811
3920118 - Sapporo Medical University Hospital
Sapporo, 060-8543
3920121 - Hokkaido Cardiovascular Hospital
Sapporo, 064-0927
3920149 - Tohoku University Hospital
Sendai, 980-8574
3920117 - Sendai Open Hospital
Sendai, 983-0824
3920132 - Tosei General Hospital
Seto-Shi, 489-8642
3920123 - Tokyo Women's Medical University Hospital
Shinjuku-Ku, 162-8666
3920104 - Shizuoka City Shizuoka Hospital
Shizuoka, 420-8630
3920120 - National Cerebral and Cardiovascular Center
Suita-Shi, 565-8565
3920126 - Kagawa Prefectural Hospital
Takamatsu, 760-0065
3920102 - Oji General Hospital
Tomakomai-Shi, 053-8506
3920128 - Tokyo Bay Urayasu Ichikawa Medical Center
Urayasu-Shi, 279-0001
3920099 - Yokohama City University Medical Center
Yokohama, 232-0024
3920133 - Kanagawa Cardiovascular and Respiratory Center
Yokohama, 236-0051
Canada33 sites
1240096 - William Osler Health System
Brampton, Ontario, L6R 3J7
1240063 - Heritage Medical Research Clinic
Calgary, Alberta, T2N 4Z6
1240032 - Royal Alexandra Hospital
Edmonton, Alberta, T5H 3V9
1240058 - University of Alberta Hospital
Edmonton, Alberta, T6G 2B7
1240065 - Hamilton Health Sciences
Hamilton, Ontario, L8L 2X2
1240102 - Royal Inland Hospital
Kamloops, British Columbia, V2C 2T1
1240101 - Kelowna General Hospital
Kelowna, British Columbia, V1Y 1T2
1240091 - Kingston General Hospital
Kingston, Ontario, K7L 2V7
1240107 - Clinique de Cardiologie de Levis
Lévis, Quebec, G6V 4Z5
1240088 - Montreal Heart Institute
Montreal, Quebec, H1T 1C8
1240092 - CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, H2X 3E4
1240106 - McGill University Health Centre (MUHC)
Montreal, Quebec, H3G 1A4
1240068 - Fraser Clinical Trials, Inc.
New Westminster, British Columbia, V3L 3W4
1240069 - York PCI Group, Inc.
Newmarket, Ontario, L3Y 2P7
1240093 - Halton Healthcare - Oakville Trafalgar Memorial Hospital
Oakville, Ontario, L6M 0L8
1240077 - Ottawa Heart Institute
Ottawa, Ontario, K1Y 4W7
1240078 - Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2
1240083 - CHU de Quebec-Universite-Laval, HDQ
Québec, Quebec, G1R 2J6
1240071 - Institut universitaire de cardiologie et de pneumologie de Quebec
Québec, G1V 4G5
1240090 - New Brunswick Heart Centre Research Initiative
Saint John, New Brunswick, E2L 4L2
1240099 - Centre Hospital Saint Georges de Beauce
Saint-Georges, Quebec, G5Y 4T8
1240081 - Saint Jerome Medical Research, Inc.
Saint-Jérôme, Quebec, J7Z 5T3
1240095 - Royal University Hospital
Saskatoon, Saskatchewan, S7N 0W8
1240087 - CIUSSS de l'Estrie-CHUS
Sherbrooke, Quebec, J1H 5N4
1240113 - Niagara Health System, St. Catherines Site
St. Catharines, Ontario, L2S 0A9
1240060 - Health Sciences Centre
St. John's, Newfoundland and Labrador, A1B 3V6
1240061 - SMH Cardiology Clinical Trials Inc.
Surrey, British Columbia, V3V 0C6
1240059 - Centre Hospitalier Pierre-Le Gardeur
Terrebonne, Quebec, J6V 2H2
1240097 - St. Michael's Hospital
Toronto, Ontario, M5B 1W8
1240079 - Toronto General Hospital
Toronto, M5G 2C4
1240066 - Centre Integre Universitaire de la Mauricie-et-du-Centre-du-Quebec
Trois-Rivières, Quebec, G8Z 3R9
1240074 - Vancouver General Hospital
Vancouver, British Colombia, V5Z 1M9
1240062 - Saint Boniface General Hospital
Winnipeg, Manitoba, R2A 2A6
Argentina32 sites
0320069 - Hospital Italiano Regional del Sur
Bahía Blanca, B8001HXM
0320020 - Clinica Privada
Buenos Aires, 1722
0320025 - Fundación Sanatorio Güemes
Ciudad Autonoma Buenos Aires, 1413
0320041 - Clinica y Maternidad Suizo Argentina (CyMSA)
Ciudad Autónoma Buenos Aires, 1118
0320019 - Hospital Británico de Buenos Aires
Ciudad Autónoma Buenos Aires, 1280
0320029 - Instituto Cardiovascular de Buenos Aires
Ciudad Autónoma Buenos Aires, 1428
0320034 - Clinica Adventista Belgrano
Ciudad Autónoma Buenos Aires, 1430
0320033 - Corporacion Medica de San Martin
Ciudad Autónoma Buenos Aires, 4071
0320015 - Clinica Chutro S.R.L.
Córdoba, 5000
0320063 - Clinica Romagosa
Córdoba, 5000
0320023 - Clínica Privada del Prado
Córdoba, X5000AAX
0320012 - Sanatorio Allende
Córdoba, X5000
0320036 - Hospital Italiano
Córdoba, X5000
0320026 - Clínica Colombo
Córdoba, X5002AOQ
0320039 - Santatorio Parque S.A.
Córdoba, X5006IKK
0320013 - Hospital Municipal de Coronel Suárez
Coronel Suárez, 7540
0320040 - Instituto de Cardiología de Corrientes
Corrientes, 3400
0320014 - Hospital Italiano La Plata
La Plata, B1897
0320016 - Sanatorio Modelo Quilmes
Quilmes, 1878
0320044 - Instituto Medico de la Fundacion de Estudios Clínicos
Rosario, 2000
0320017 - Entidades Vinculadas al Sanatorio Parque
Rosario, S2000
0320071 - Hospital Provincial del Centenario
Rosario, S2000
0320070 - Hospital Papa Francisco
Salta, 4400
0320073 - Instituto Medico De Alta Complejidad - IMAC
Salta, 4401
0320022 - Hospital El Cruce
San Juan Bautista, 1888
0320037 - Centro Privado de Cardiologia (CPC)
San Miguel de Tucumán, 4000
0320027 - Estudios Clínicos de los Arroyos
San Nicolás, 2900
0320021 - Sanatorio Medico de Diagnostico y Tratamiento S.A.
Santa Fe, 3000
0320038 - Sanatorio Mayo Privado S.A.
Santa Fe, 3000
0320032 - Hospital Dr. Jose Maria Cullen
Santa Fe, S3000
0320067 - Sanatorio Santa Rosa
Santa Rosa, P3600
0320054 - Clínica Privada de Especialidades Médicas de Villa María
Villa María, 5901
Russia32 sites
6430075 - First City Clinical Hospital named after E. E. Volosevich
Arkhangelsk, 163001
6430069 - Regional Clinical Hospital
Barnaul, 656024
6430060 - Regional State Budgetary Institution of Public Health
Barnaul, 656055
6430068 - Regional Budgetary Healthcare Institution "Cardiology Dispensary"
Ivanovo, 153012
6430116 - City hospital # 2 "Sosnovaya roscha"
Kaluga, 248010
6430079 - Scientific-Research Institute of Complex Problems of Cardio
Kemerovo, 650002
6430048 - City Clinical Hospital No. 6 named after Karpovicha
Krasnoyarsk, 660062
6430050 - Kursk City Emergency Care Hospital
Kursk, 305035
6430063 - Lyubertsy Regional Hospital No. 2
Lyubertsy, 140006
6430105 - City Clinical Hospital No. 51
Moscow, 121309
6430091 - City clinical hospital #15 n.a. O.M. Filatov
Moskva, 111539
6430080 - City Clinical Hospital No. 5
Nizhny Novgorod, 603005
6430110 - SBHI of Novosibirsk Region "City Clinical Hospital of Emergency Care #2"
Novosibirsk, 630008
6430058 - State Budget Healthcare Institution of Novosibirsk Region "C
Novosibirsk, 630054
6430047 - Novosibirsk Regional Clinical Hospital
Novosibirsk, 630087
6430045 - Penza Regional Clinical Hospital n.a. N.N.Burdenko
Penza, 440026
6430054 - City Clinical Hospital No. 4
Perm, 614017
6430064 - City Hospital for Emergency Care of Rostov-on-Don
Rostov-on-Don, 344068
6430070 - Saint-Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Saint Petersburg, 192242
6430074 - St. Petersburg State Institution of Healthcare
Saint Petersburg, 193312
6430107 - Clinical Hospital of the Russian Academy of Science
Saint Petersburg, 194017
6430081 - Saint Petersburg State Medical Academy
Saint Petersburg, 195067
6430115 - Pavlov First Saint Petersburg State Medical University
Saint Petersburg, 197101
6430049 - Pokrovskaya Municipal Hospital
Saint Petersburg, 199106
6430072 - Samara Regional Cardiology Dispensary
Samara, 443070
6430067 - Saratov State Medical University named after V.I. Razumovsky
Saratov, 410012
6430042 - Research Institute of Cardiology
Tomsk, 634012
6430043 - Tula Regional Clinical Hospital
Tula, 300053
6430053 - Tyumen Cardiology Center
Tyumen, 625026
6430111 - Clinical Hospital No. 8
Yaroslavl, 150030
6430092 - Yaroslavl Regional Clinical Hospital
Yaroslavl, 150062
6430108 - Novaya Bolnitsa
Yekaterinburg, 620109
Netherlands29 sites
5280054 - Noordwest Ziekenhuisgroep - Alkmaar
Alkmaar, 1815 JD
5280031 - Meander Medisch Centrum - Locatie Amersfoort
Amersfoort, 3813 TZ
5280057 - Bovenij ziekenhuis
Amsterdam, 1034 CS
5280039 - OLVG Location West
Amsterdam, 1061 AE
5280061 - Amsterdam UMC - VUMC
Amsterdam, 1081 HV
5280016 - Onze Lieve Vrouwe Gasthuis
Amsterdam, 1091 AC
5280048 - Amphia Zienkenhuis - Locatie Molengracht Breda
Breda, 4818 CK
5280047 - Deventer Hospital
Deventer, 7416 SE
5280013 - Ziekenhuis Gelderse Vallei
Ede, 6710 HN
5280040 - Maxima Medisch Centrum
Eindhoven, 5631 BM
5280049 - Medisch Spectrum Twente
Enschede, 7513 ER
5280038 - Admiraal de Ruijter Ziekenhuis - Locatie Goes
Goes, 4462 RA
5280056 - Groene Hart Ziekenhuis - Gouda
Gouda, 2803 HH
5280034 - Spaarne Gasthuis
Haarlem, 2035 RC
5280052 - Ziekenhuis St Jansdal
Harderwijk, 3844 DG
5280063 - Zuyderland Medisch Centrum, Heerlen
Heerlen, 6419 PC
5280037 - Dijklander Ziekenhuis - Hoorn
Hoorn, 1624 NP
5280045 - Medisch Centrum Leeuwarden
Leeuwarden, 8934 AD
5280064 - Alrijne Ziekenhuis Leiden
Leiden, 2334 CK
5280043 - Radboud UMC
Nijmegen, 6525 GA
5280036 - Canisius-Wilhelmina Ziekenhuis
Nijmegen, 6532 SZ
5280062 - Sint Franciscus Gasthuis
Rotterdam, 3045 PM
5280018 - Maasstad Ziekenhuis
Rotterdam, 3079 DZ
5280035 - D & A Research
Sneek, 8601 ZR
5280060 - Ziekenhuis Rivierenland - Cardiologie
Tiel, 4002 WP
5280042 - Elisabeth TweeSteden Ziekenhuis Vestiging Tilburg
Tilburg, 5042 AD
5280058 - Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX
5280020 - VieCuri
Venlo, 5912 BL
5280046 - Gelre Ziekenhuizen - Zutphen
Zutphen, 7207 AE
Germany27 sites
2760133 - SLK - Klinikum am Plattenwald
Bad Friedrichshall, 74177
2760143 - Vivantes Klinikum Am Urban
Berlin, 10967
2760184 - Praxis Dr. Med. Nicole Toursarkissian
Berlin, 13347
2760170 - Charite - UB - CVK - Medizinische Klinik
Berlin, 13353
2760146 - Innere Medizin I, Marienhaus Klinikum Eifel Bitburg
Bitburg, 54634
2760155 - Universitätsklinikum Bonn
Bonn, 53127
2760141 - Klinikum Coburg GmbH
Coburg, 96450
2760139 - Staedtisches Klinikum Dresden-Friedrichstadt - I. Medizinisc
Dresden, 01067
2760243 - HELIOS Klinikum Erfurt
Erfurt, 99089
2760164 - Elisabeth-Krankenhaus Essen GmbH Klinik für Kardiologie und Angiologie
Essen, 45138
2760193 - CardioVaskulares Centrum Frankfurt
Frankfurt am Main, 60389
2760168 - Klinikum Frankfurt Höchst GmbH
Frankfurt am Main, 65929
2760119 - Universitätsklinikum Freiburg
Freiburg im Breisgau, 79106
2760219 - Universitätsklinikum Freiburg
Freiburg im Breisgau, 79106
2760190 - Asklepios Kliniken Hamburg GmbH
Hamburg, 21075
2760140 - Cardiologicum Hamburg - Studienzentrum
Hamburg, 22041
2760188 - Asklepios Klinik Barmbek
Hamburg, 22291
2760149 - Asklepios Klinik Altona
Hamburg, 22763
2760135 - University Hospital Jena
Jena, 07743
2760132 - Ambulantes Herzzentrum Kassel
Kassel, 34121
2760181 - Asklepios Klinik Langen
Langen, 63225
2760111 - Klinikum der Stadt Ludwigshafen gGmbH
Ludwigshafen, 67063
2760130 - Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz, 55131
2760186 - Katholisches Klinikum Mainz - Klinik fuer Innere Medizin I
Mainz, 55131
7240030 - Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz, 55131
2760147 - GPR Klinikum Rüsselsheim II - Medizinische Klinik Innere Medizin
Rüsselsheim am Main, 65428
2760176 - Evangelisches Krankenhaus Witten
Witten, 58455
Poland24 sites
6160082 - II Oddział Kardiologiczny PAKS
Bielsko-Biala, 43-316
6160063 - Klinika Kardiologii i Kardiochirurgii 10 WSK
Bydgoszcz, 85-681
6160081 - McSn
Chrzanów, 32-500
6160065 - III Oddział Kardiologii Inwazyjnej, Angiologii i Elektrokard
Dąbrowa Górnicza, 41-300
6160054 - SPS Szpital Zachodni
Grodzisk Mazowiecki, 05-825
6160066 - IV Oddział Kardiologii Inwazyjnej, Elektrostymulacji i Angio
Kędzierzyn-Koźle, 47-200
6160078 - Nowy Szpital Uniwersytecki w Krakowie-Prokocimiu
Krakow, 30-688
6160051 - Krakowski Szpital Specjalistyczny im. Jana Pawła II
Krakow, 31-202
6160095 - Centrum Kardiologii Inwazyjnej i Angiologii w Krośnie
Krosno, 38-400
6160096 - 1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ w Lublinie
Lublin, 20-028
6160062 - Wielospecjalistyczny Szpital Samodzielny Publiczny Zakład Op
Nowa Sól, 67-100
6160064 - Medicome sp.zoo
Oświęcim, 32-600
6160100 - Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii
Pińczów, 28-400
6160077 - Samodzielny Publiczny Zakład Opieki Zdrowotnej w Puławach
Puławy, 24-100
6160088 - Ikardia
Puławy, 24-100
6160080 - Regional Public Specialty Hospital "Latawiec"
Swidnica, 58-100
6160067 - Szpital Polski - Sztum
Sztum, 82-400
6160061 - Wojewódzki Szpital Zespolony im. Ludwika Rydygiera w Toruniu
Torun, 87-100
6160073 - American Heart of Poland
Tychy, 43-100
6160093 - Specjalistyczny Szpital im. dr Alfreda Sokolowskiego
Wałbrzych, 58-309
6160052 - Szpital Wolski
Warsaw, 01-211
6160075 - Szpital Bielanski
Warsaw, 01-809
6160086 - Dept. of Interventional cardiology and Angiology, Institute
Warsaw, 04-628
6160083 - Wojewódzki Szpital Specjalistyczny im. Marii Skłodowskiej-Curie
Zgierz, 95-100
Ukraine23 sites
8040019 - Cherkasy Regional Cardiological Center
Cherkasy, 18009
8040010 - Dnipropetrovsk Medical Academy, Dnipropetrovsk Joint Emergen
Dnipro, 49006
8040037 - The Ivano-Frankivsk National Medical Univeristy
Ivano-Frankivsk, 76005
8040032 - Ivano-Frankivskyy oblasnyy klinichnyy kardiologichnyy dyspan
Ivano-Frankivsk, 76018
8040048 - Communal Institution of Healthcare "Kharkiv Municipal Clinic
Kharkiv, 61002
8040017 - National Institute of Therapy named after L.T. Malaya NAMS o
Kharkiv, 61039
8040050 - Regional Clinical Hospital - Emergency Medical Care
Kharkiv, 61058
8040012 - Kharkiv City Clinical Hospital #8
Kharkiv, 61176
8040013 - Khmelnytskyi Regional Hospital
Khmelnytskyi, 29000
8040047 - Oleksandrivska Clinical Hospital
Kyiv, 01601
8040008 - Kyiv City Clinical Hospital No. 1
Kyiv, 02000
8040021 - Heart Institute of the Ministry of Health of Ukraine
Kyiv, 02660
8040009 - Kiev City Clinical Hospital No. 5
Kyiv, 03115
8040025 - National Scientific Center
Kyiv, 03680
8040049 - Lutsk City Clinical Hospital
Lutsk, 43000
8040016 - Lviv National Medical University named by Danylo Halitskyy
Lviv, 79000
8040035 - Lviv Regional State Clinical-and-Diagnostic Cardiology Cente
Lviv, 79015
8040038 - City Hospital 4
Mykolaiv, 54003
8040014 - Odessa Regional Hospital
Odesa, 65025
8040015 - Ternopil University Hospital
Ternopil, 46001
8040020 - Uzhgorod National University
Uzhhorod, 88014
8040036 - Regional Medical Center for Cardiovascular Diseases
Zaporizhzhya, 69005
8040023 - Zhitomir Regional Clinical Hospital
Zhytomyr, 10002
Belgium22 sites
0560024 - Onze-Lieve-Vrouwziekenhuis VZW (OLV)
Aalst, 9300
0560043 - Algemeen Stedelijk Ziekenhuis
Aalst, 9300
0560027 - ZNA Middelheim
Antwerp, 2020
0560028 - AZ Klina
Brasschaat, 2930
0560020 - AZ Sint-Jan Brugge-Oostende AV
Bruges, 8000
0560015 - Clinique Saint Jean
Brussels, 1000
0560023 - Centre Hospitalier Universitaire Brugmann
Brussels, 1020
0560016 - Ziekenhuis Oost-Limburg
Genk, 3600
0560037 - Universitair Ziekenhuis Gent
Ghent, 9000
0560045 - AZ Sint-Lucas
Ghent, 9000
0560038 - Jessa Ziekenhuis
Hasselt, 3500
0560019 - Centre Hospitalier Régional de Huy
Huy, 4500
0560026 - Universitair Ziekenhuis Brussel
Jette, 1090
0560046 - AZ Groeninge - Campus Kennedylaan
Kortrijk, 8500
0560022 - Centre Hospitalier Universitaire de Tivoli
La Louvière, 7100
0560036 - Universitair Ziekenhuis Leuven
Leuven, 3000
0560017 - CHR de la Citadelle
Liège, 4000
0560053 - AZ Sint-Maarten
Mechelen, 2800
0560044 - Heilig Hartziekenhuis Mol
Mol, 2400
0560032 - AZ Delta
Roeselare, 8800
0560018 - AZ Glorieux
Ronse, 9600
0560040 - Campus Saint Elizabeth
Turnhout, 2300
Australia21 sites
0360057 - Royal Adelaide Hospital
Adelaide, South Australia, 5000
0360032 - Flinders Medical Centre
Bedford Park, South Australia, 5042
0360063 - Cairns Base Hospital
Cairns, Queensland, 4870
0360087 - Campbelltown Hospital
Campbelltown, New South Wales, 2560
0360062 - The Prince Charles Hospital
Chermside, Queensland, 4032
0360092 - Monash Medical Centre
Clayton, Victoria, 3168
0360036 - The Northern Hospital
Epping, Victoria, 3076
0360096 - Peninsula Health
Frankston, Victoria, 3199
0360076 - Geelong Hospital
Geelong, Victoria, 3320
0360061 - Royal Brisbane Hospital
Herston, Queensland, 4029
0360084 - Royal Hobart Hospital
Hobart, Tazmania, 7001
0360081 - Peninsula Heart Centre
Langwarrin, Victoria, 3910
0360069 - Liverpool Hospital
Liverpool, New South Wales, 2170
0360073 - The Alfred Hospital
Melbourne, Victoria, 3004
0360080 - Fiona Stanley Hospital
Murdoch, Western Australia, 6150
0360072 - John Hunter Hospital
New Lambton Heights, 2305
0360059 - Royal Perth Hospital
Perth, Western Australia, 6000
0360060 - Gold Coast Hospital
Southport, Queensland, 4215
0360070 - Royal North Shore Hospital
St Leonards, New South Wales, 2065
0360071 - Wollongong Hospital
Wollongong, New South Wales, 2500
0360055 - Queen Elizabeth Hospital
Woodville South, South Australia, 5011
Bulgaria21 sites
1000023 - MHAT "Pulse AD"
Blagoevgrad, 2700
1000043 - Multiprofile Hospital for Active Treatment Blagoevgrad AD
Blagoevgrad, 2700
1000074 - "UMHAT Deva Mariya" EOOD
Burgas, 8000
1000072 - Multiprofile Hospital for Active Treatment - Dobrich AD
Dobrich, 9300
1000029 - Multiprofile Hospital for Active Treatment AD Haskovo
Haskovo, 6300
1000045 - MHAT City Clinic - Sv. Georgi EOOD
Lom, 3600
1000036 - MHAT-Higia
Pazardzhik, 4400
1000053 - Multiprofile Hospital For Active Treatment - Pazardzhik AD
Pazardzhik, 4400
1000049 - SHATC Sv. Georgi - Pernik
Pernik, 2300
1000071 - University Multiprofile Hospital for Active Treatment "Dr. G"
Pleven, 5803
1000057 - Specialized Hospital for Active Treatment in Cardiology EAD
Pleven, 5804
1000058 - Multiprofile Hospital for Active Treatment Plovdiv AD
Plovdiv, 4003
1000044 - Second Multiprofile Hospital for Active Treatment - Sofia EA
Sofia, 1202
1000054 - Multiprofile Hospital for Active Treatment "National Cardiac Hospital"
Sofia, 1309
1000070 - University Multiprofile Hospital for Active Treatment Alexa
Sofia, 1431
1000033 - University Multiprofile Hospital for Active Treatment
Sofia, 1527
1000047 - University Hospital for Active Treatment & Emergency Medicine
Sofia, 1606
1000035 - "MHAT "Sveta Anna"" - Sofia AD
Sofia, 1750
1000038 - Acibadem City Clinic University Hospital, EOOD
Sofia, 1784
1000028 - SHAT Cardiology Varna - EAD
Varna, 9002
1000024 - Multiprofile District Hospital
Veliko Tarnovo, 5000
France21 sites
2500081 - CHU Besançon - Hôpital Jean Minjoz
Besançon, 25000
2500163 - CHU Caen
Caen, 14033
2500162 - CHRU de Tours - Hopital Trousseau
Chambray-lès-Tours, 37170
2500107 - Centre Hospitalier Sud Francilien
Corbeil-Essonnes, 91100
2500103 - CHU de Grenoble
Grenoble, 38019
2500078 - Centre Hospitalier Louis Pasteur
Le Coudray, 28630
2500117 - Centre Chirurgical Marie Lannelongue
Le Plessis-Robinson, 92350
2500112 - Centre Hospitalier Régional Universitaire de Lille (CHRU)
Lille, 59037
2500082 - Clinique du Pont de Chaume
Montauban, 82000
2500091 - CHRU Montpellier - Arnaud de Villeneuve
Montpellier, 34090
2500110 - CHU de Nantes
Nantes, 44000
2500079 - CHU de Nice - Hôpital Pasteur
Nice, 06000
2500105 - CHU de Nimes - Hopital Universitaire Caremeau
Nîmes, 30029
2500090 - Hôpital Lariboisière
Paris, 75010
2500046 - Hopital Pitie-Salpetriere
Paris, 75013
2500101 - Hopital Paris Saint Joseph
Paris, 75014
2500042 - CHU Hopitaux de Bordeaux - Hôpital Haut-Lévêque
Pessac, 33604
2500165 - CHU de Poitiers
Poitiers, 86000
2500120 - Centre Hospitalier Annecy Genevois
Pringy, 74374
2500092 - Centre Hospitalier Régional Metz-Thionville
Thionville, 57100
2500080 - CHU de Toulouse - Hopital Rangueil - Cardiologie
Toulouse, 31659
Israel21 sites
3760021 - Emek Medical Center
Afula, 18101
3760041 - Emek Medical Center
Afula, 18101
3760028 - Barzilai Medical Center
Ashkelon, 78278
3760034 - Assaf Harofeh Medical Center - Cardiology Division
Be’er Ya‘aqov, 70300
3760024 - Soroka Medical Center
Beersheba, 85025
3760032 - Hillel Yaffe Medical Center
Hadera, 38100
3760022 - Bnai Zion Medical Center
Haifa, 33394
3760014 - Rambam Medical Center
Haifa, 9602
3760012 - Hadassah Ein Karem Hospital
Jerusalem, 90000
3760023 - Shaare Zedek Medical Center
Jerusalem, 91031
3760029 - Hadassah Medical Center-Mount Scopus
Jerusalem, 91240
3760037 - Tel Aviv University Sackler School of Medicine - Meir Medica
Kfar Saba, 44218
3760020 - Galilee Medical Center
Nahariya, 22100
3760026 - The Baruch Padeh Medical Center
Nazareth, 16100
3760035 - The Baruch Padeh Medical Center
Nazareth, 16100
3760025 - Rabin Medical Center - Hasharon Hospital
Petah Tikva, 49100
3760018 - Leviev Heart Center, Chaim Sheba Medical Center
Ramat Gan, 5265601
3760027 - Kaplan Medical Center
Rehovot, 76100
3760019 - Ziv MC
Safed, 13100
3760036 - Assuta Medical Center
Tel Aviv, 60000
3760038 - Tel Aviv Sourasky Medical Center
Tel Aviv, 64239
Mexico20 sites
4840014 - Investigacion Biomedica para el Desarrollo de Farmacos S.A d
Aguascalientes, 20010
4840004 - Hospital Cardiológica Aguascal
Aguascalientes, 20230
4840077 - Unidad de Investigacion en Salud (UIS)
Chihuahua City, 01317
4840046 - Unidad de Investigacion
Chihuahua City, 31200
4840006 - Centro para el Desarrollo de la Medicina y de Asistencia Méd
Culiacán, 80230
4840008 - Hospital Civil de Guadalajara - Nuevo Hospital Civil de Guadalajara
Guadalajara, Jalisco, 44340
4840033 - Virgen Cardiovascular Research S.C.
Guadalajara, 44670
4840020 - Centro de Estudios de Alta Especialidad de Sinaloa, S.C.
Mazatlán, 82126
4840016 - Instituto Nacional de Cardiologia Ignacio Chavez
México, 14080
4840034 - Hospital de Jesus
Mexico City, 06090
4840045 - OCA Hospital - Monterrey International Research Center
Monterrey, 64018
4840036 - Cardiolink Clin Trials, SC.
Monterrey, 64060
4840021 - Universidad Autonoma de Nuevo Leon - Hospital Universitario
Monterrey, 64460
4840007 - Unidad de Prevención y Atención Cardiometabólica (UPAC)
Morelia, 58260
4840074 - Unidad de Investigación y Salud de Puebla S.C.
Puebla City, 72197
4840003 - Centro de Estudios Clínicos de Querétaro, SC
Querétaro, 76000
4840022 - Centro de Atencion e Investigacion Cardiovascular del Potosi
San Luis Potosí City, 78200
4840025 - Hospital Central "Dr. Ignacio Morones Prieto"
San Luis Potosí City, 78290
4840076 - CIMAB S.A. de C.V.
Torreón, 27000
4840018 - Centro de Alta Especialidad Dr. Rafael Lucio
Xalapa, 02903
Romania20 sites
6420052 - Spitalul Judeţean de Urgenţă "Dr. Constantin Opriş" Baia Mar
Baia Mare, 430031
6420053 - Spitalul Clinic Judetean de Urgenta Brasov
Brasov, 500326
6420046 - Spitalului Universitar de Urgenţă Militar Central "Dr. Carol Davila"
Bucharest, 010825
6420090 - Spitalul Clinic de Urgenţă "Bagdasar-Arseni"
Bucharest, 041915
6420043 - Spitalul Universitar de Urgenta Bucuresti
Bucharest, 050098
6420050 - Spitalul Universitar de Urgent
Bucharest, 11461
6420051 - Institutul Inimii "Niculae Stancioiu"
Cluj-Napoca, 400001
6420088 - Institutul Inimii "Niculae Stancioiu"
Cluj-Napoca, 400001
6420060 - Spitalul Clinic Judetean de Urgenta Cluj-Napoca
Cluj-Napoca, 400006
6420080 - Spitalul Clinic de Recuperare Cluj-Napoca
Cluj-Napoca, 400347
6420044 - Spitalul Clinic Judetean de Ur
Craiova, 200642
6420057 - Institutul de Boli Cardiovasculare "Prof. Dr. George I. M. Georgescu
Iași, 700503
6420045 - Spitalul Clinic Judeţean de Urgenţă Oradea
Oradea, 410159
6420048 - Spitalul Judetean de Urgenta Pitesti-Arges
Piteşti, 110084
6420079 - Spitalul Clinic Judetean de Urgenta Sibiu
Sibiu, 550245
6420047 - Spitalul de Urgenta "Sf. Ioan Cel Nou" Suceava
Suceava, 720284
6420059 - Institutul de Urgenta pentru Boli Cardiovasculare si Transplant
Târgu Mureş, 540136
6420049 - Spitalul Clinic Judetean de Urgenta Tîrgu - Mures
Târgu Mureş, 5401
6420071 - Institutului de Boli Cardiovasculare Timişoara
Timișoara, 300310
6420083 - Institutului de Boli Cardiovasculare Timişoara
Timișoara, 300310
Hungary17 sites
3480016 - Budai Irgalmasrendi Kórház
Budapest, 1023
3480024 - Bajcsy-Zsilinszky Hospital
Budapest, 1106
3480033 - Semmelweis University, Faculty of Medicine
Budapest, 1125
3480028 - Magyar Honvédség Egészségügyi Központ
Budapest, 1134
3480040 - Jahn Ferenc Dél-pesti Kórház és Rendelőintézet
Budapest, 1204
3480019 - Debreceni Egyetem Klinikai Központ
Debrecen, 4032
3480025 - Dombovari Szent Lukacs Egeszsegugyi Kft
Dombóvár, 7200
3480023 - Petz Aladar County Teaching Hospital
Győr, 9023
3480029 - Békés Megyei Pándy Kálmán Kórház
Gyula, 5700
3480045 - Somogy Megyei Kaposi Mór Oktató Kórház
Kaposvár, 7400
3480036 - Bács-Kiskun Megyei Kórház
Kecskemét, 6000
3480015 - Jósa András Oktatókórház
Nyíregyháza, 4400
3480022 - University of Szeged - Second Department of Medicine & Cardiology Centre
Szeged, 6725
3480020 - Fejér Megyei Szent György Egyetemi Oktató Kórház
Székesfehérvár, 8000
3480035 - Tolna Megyei Balassa Janos Korhaz
Szekszárd, 7100
3480018 - Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Rendelőintéz
Szolnok, 5000
3480026 - Zala Megyei Szent Rafael Kórház
Zalaegerszeg, 8900
Italy17 sites
3800062 - ASST Papa Giovanni XXIII
Bergamo, 24127
3800075 - ASST degli Spedali Civili di Brescia
Brescia, 25123
3800170 - Fondazione Poliambulanza Istituto Ospedaliero
Brescia, 25124
3800085 - Azienda Socio-Sanitaria Territoriale della Valle Olona
Busto Arsizio, 21052
3800079 - Azienda Ospedaliera di Caserta "Sant'Anna e San Sebastiano"
Caserta, 81100
3800107 - Università degli Studi "Magna Graecia" di Catanzaro
Catanzaro, 88100
3800129 - Azienda Ospedaliero-Universitaria Careggi
Florence, 50134
3800141 - IRCCS MultiMedica
Milan, 20126
3800088 - Centro Cardiologico Monzino
Milan, 20138
3800087 - Azienda Ospedaliera Universitaria "Federico II"
Naples, 80131
3800123 - AORN - Ospedali dei Colli Ospedale V. Monaldi
Naples, 80131
3800090 - Gruppo Ospedaliero San Donato - Policlinico San Marco
Osio Sotto, 24040
3800082 - Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
Palermo, 90127
3800110 - Fondazione IRCCS Policlinico San Matteo
Pavia, 27100
3800080 - ASL Roma 2
Roma, 00157
3800106 - Università degli Studi di Roma "La Sapienza"
Roma, 00185
3800056 - Istituto Clinico Humanitas
Rozzano, 20089
Serbia16 sites
6880014 - Klinički Centar Srbije
Belgrade, Savski Venac, 11000
6880008 - Clinical Center of Serbia -- Division of Cardiology
Belgrade, 11000
6880009 - Department of Cardiology, Clinical Center of Serbia and Belgrade
Belgrade, 11000
6880019 - KBC "Dr Dragiša Mišović-Dedinje"
Belgrade, 11000
6880023 - Kliničko Bolnički Centar Zvezdara
Belgrade, 11050
6880012 - Institute of Cardiovascular Diseases of Vojvodina
Kamenitz, 21204
6880010 - Klinički Centar Kragujevac
Kragujevac, 34111
6880015 - General Hospital Leskovac
Leskovac, 16000
6880016 - Klinički Centar Niš
Niš, 18000
6880026 - Opšta Bolnica Pančevo
Pančevo, 26101
6880018 - Klinički Centar Srbije
Savski Venac, 11000
6880013 - General Hospital Sremska Mitrovica
Sremska Mitrovica, 22000
6880027 - General Hospital Subotica
Subotica, 24107
6880020 - Zdravstveni Centar Užice
Užice, 31 000
6880025 - General Hospital Valjevo
Valjevo, 14106
6880024 - Opsta Bolnica "Dorde Joanovic" Zrenjanin
Zrenjanin, 23101
Spain16 sites
7240035 - Complexo Hospitalario Universitario A Coruña
A Coruña, 15006
7240043 - Hospital Universitario Fundación Alcorcón
Alcorcón, 28922
7240064 - Hospital General Universitario de Alicante
Alicante, 03010
7240062 - Hospital del Mar
Barcelona, 08003
7240050 - Hospital de la Santa Creu i Sant Pau
Barcelona, 08025
7240063 - Hospital Universitario Vall d'Hebron
Barcelona, 08035
7240033 - Hospital Clínic de Barcelona
Barcelona, 08036
7240076 - Hospital Juan Ramón Jiménez
Huelva, 21005
7240053 - Hospital Universitari de Bellvitge (IDIBELL)
L'Hospitalet de Llobregat, 08907
7240077 - Hospital Universitari Arnau de Vilanova de Lleida
Lleida, 25198
7240045 - Hospital Universitario Ramón y Cajal
Madrid, 28034
7240070 - Hospital Universitario Virgen Arrixaca
Murcia, 30120
7240068 - Hospital Universitario Marqués de Valdecilla
Santander, 39010
7240032 - Hospital Universitari Joan XXIII de Tarragona
Tarragona, 43005
7240034 - Hospital Clinico Universitario de Valencia
Valencia, 46010
7240100 - Hospital Álvaro Cunqueiro
Vigo, 36312
United Kingdom15 sites
8260102 - Queen Elizabeth Hospital Birmingham
Birmingham, B15 2WB
8260057 - Mid Essex Hospital Services NHS Trust - Broomfield Hospital
Chelmsford, CM1 7ET
8260071 - Ashford and St Peter's Hospitals NHS Foundation Trust
Chertsey, KT16 0PZ
8260055 - NHS National Waiting Times Centre Golden Jubilee National Hospital
Clydebank, G81 4DY
8260058 - Royal Devon & Exeter NHS Foundation Trust
Exeter, EX2 5DW
8260093 - The London North West Healthcare NHS Trust - Northwick Park
Harrow, HA1 3UJ
8260088 - Kettering General Hospital NHS Foundation Trust
Kettering, NN16 8UZ
8260043 - University Hospitals of Leicester NHS Trust - Glenfield
Leicester, LE3 9QP
8260101 - United Lincolnshire Hospitals NHS Trust - Lincoln County Hospital
Lincoln, LN2 5QY
8260086 - Manchester University NHS Foundation Trust - Manchester Royal Infirmary
Manchester, M13 9WL
8260065 - Milton Keynes Hospital NHS Foundation Trust
Milton Keynes, MK6 5LD
8260134 - The Newcastle upon Tyne Hospitals NHS Foundation Trust - Fre
Newcastle upon Tyne, NE7 7DN
8260068 - Morriston Hospital
Swansea, SA6 6NL
8260066 - Torbay and South Devon NHS Foundation Trust - Torbay Hospital
Torquay, TQ2 7AA
8260099 - The Royal Wolverhampton NHS Trust - New Cross Hospital
Wolverhampton, WV10 0QP
South Korea14 sites
4100021 - Chungbuk National University Hospital
Cheongju-si, 28644
4100016 - Veterans Health Service Medical Center
Gangdong, 05368
4100013 - Kyung Hee University Medical Center
Hoegi-dong, Dongdaemun-gu, 02447
4100017 - Chungnam National University Hospital
Junggu, 35015
4100024 - Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620
4100020 - Kyung Hee University Hospital at Gangdong
Seoul, Gangdong-gu, 05278
4100019 - Kangbuk Samsung Hospital
Seoul, Jongro-gu, 03181
4100025 - Korea University Anam Hospital
Seoul, Seongbuk-gu, 02841
4100008 - Seoul National University Hospital
Seoul, 03080
4100018 - Asan Medical Center
Seoul, 05505
4100010 - The Catholic University of Korea, St. Vincent's Hospital
Suwon, 16247
4100014 - Yonsei University, Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, 26426
4100015 - Pusan National University Yangsan Hospital
Yangsan, Gyeongsangnam-do, 50612
4100022 - Hallym University Sacred Heart Hospital
Yeongdeungpo-dong, 07441
Turkey (Türkiye)14 sites
7920024 - Afyon Kocatepe University Medical Faculty Dept. Of Cardiology
Afyonkarahisar, 03200
7920030 - T. C. Saglık Bakanlıgı - Bagcılar Egitim ve Arastırma Hastan
Bağcılar, 34100
7920018 - Cukurova University School Of Medicine Balcali Hospital
Balcalı, 01330
7920023 - Ege Üniversitesi Tıp Fakültesi
Bornova, 35100
7920016 - Ankara Sehir Hastanesi Bilkent
Çankaya, 06800
7920021 - Istanbul Universitesi Istanbul Tip Fakultesi
Çapa, 34390
7920017 - Eskişehir Osmangazi Üniversitesi Tıp Fakültesi
Eskişehir, 26480
7920012 - Istanbul Universitesi Cerrahpasa Tip Fakultesi Hastanesi
Fatih, 34096
7920022 - Marmara Universitesi Tip Fakultesi
Istanbul, 81326
7920032 - Kocaeli Universitesi Tip Fakultesi - Kardiyoloji Anabilim Dalı Başkanı
Kocaeli, 4138
7920015 - T.C. Saglik Bakanligi - Kartal Kosuyolu Yuksek Ihtisas Egitim
Maltepe, 34846
7920014 - Mersin Üniversitesi Tip Fakültesi
Mersin, 33079
7920026 - Ondokuz Mayis Üniversitesi - Kardiyoloji Anabilim Dalı
Samsun, 55280
7920025 - Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi - Kardiyo
Yıldırım, 16310
Czechia13 sites
2030048 - Fakultní Nemocnice Brno
Brno, 625 00
2030057 - Fakultní Nemocnice Hradec Králové
Hradec Králové, 500 05
2030031 - Nemocnice Jablonec nad Nisou, p.o.
Jablonec nad Nisou, 466 01
2030073 - Karlovarska Krajska Nemocnice a.s.
Karlovy Vary, 360 01
2030040 - Oblastní Nemocnice Kladno, a.s.
Kladno, 272 01
2030061 - Oblastní nemocnice Náchod, a.s
Náchod, 547 01
2030041 - Nemocnice Pardubickeho kraje, a.s. - Pardubicka nemocnice
Pardubice, 532 03
2030020 - Fakultní nemocnice Královské Vinohrady
Prague, 100 34
2030038 - Vseobecna Fakultni Nemocnice, Ustav hematologie a krevni transfuze
Prague, 128 00
2030052 - Všeobecná fakultní nemocnice v Praze
Prague, 128 00
2030071 - Ústřední vojenská nemocnice - Vojenská fakultní nemocnice Praha
Prague, 162 00
2030050 - Nemocnice Slaný
Slaný, 274 01
2030059 - Uherskohradišťská nemocnice a.s.
Uherské Hradiště, 686 68
Denmark12 sites
2080012 - Aalborg Universitetshospital
Aalborg, 9000
2080022 - Amager Sygehus - Kardiologisk Klinik
Copenhagen, 2300
2080009 - Sydvestjysk Sygehus - Esbjerg
Esbjerg, 6700
2080021 - Amager and Hvidovre Hospital - Medical Department
Glostrup Municipality, 2600
2080011 - Gentofte Hospital
Hellerup, 2900
2080016 - Medicinsk Afdeling - Herning Sygehus
Herning, 7400
2080008 - Hvidovre Hospital
Hvidovre, 2650
2080015 - Koege Sygehus - University Hospital Sjaelland
Køge, 4600
2080019 - Sjaellands Universitetshospital - Kardiologisk Afdeling
Roskilde, 4000
2080018 - Regionshospitalet Silkeborg
Silkeborg, 8600
2080014 - Svendborg Sygehus, Ward "Forskningsenheden Afd M Svendborg"
Svendborg, 5700
2080020 - Hjertesygdomme | Regionshospitalerne i Viborg og Skive
Viborg, 8800
Colombia11 sites
1700007 - Fundacion Cardiomet Eje Cafetero CEQUIN
Armenia, 630004
1700008 - Clinica de la Costa
Barranquilla, 080012
1700006 - Hospital Universitario San Ignacio
Bogotá, 110231
1700011 - Fundación Valle del Lili
Cali, 760032
1700010 - Centro Medico Imbanaco
Cali, 760042
1700017 - Fundación Cardiovascular de Colombia
Floridablanca, 681002
1700012 - Fundación Oftalmológica de Santander - Clinica FOSCAL
Floridablanca, 681004
1700018 - Caja de Compensacion Familiar de Caldas
Manizales, 170003
1700013 - Rodrigo Botero SAS
Medellín, 050012
1700015 - Hospital Pablo Tobon Uribe
Medellín, 050034
1700024 - Fundación Hospitalaria San Vicente de Paul
Medellín, 50018
Georgia11 sites
2680018 - TSMU - Alexandre Aladashvili University Clinic
Tbilisi, 0102
2680002 - Helsicore - Israeli Georgian Medical Research Clinic
Tbilisi, 0112
2680020 - Cardiological Clinic "Guli"
Tbilisi, 0144
2680004 - Clinical Cardology Institute Ltd.
Tbilisi, 0159
2680012 - Chapidze Emergency Cardiology Center
Tbilisi, 0159
2680013 - Tbilisi Heart and Vascular Clinic LTD
Tbilisi, 0159
2680015 - Chapidze Emergency Cardiology Center
Tbilisi, 0159
2680026 - Georgian-Dutch Hospital MEDISON
Tbilisi, 0159
2680010 - MediClub Georgia
Tbilisi, 0160
2680027 - Tbilisi State Medical University (TSMU) - S. Khechinashvili
Tbilisi, 0179
2680023 - LTD "Samgori Medi"
Tbilisi, 0190
Greece11 sites
3000027 - GENERAL HOSPITAL Korgialenio - Benakio HRC
Athens, 115 26
3000022 - University of Athens - Hippokration General Hospital
Athens, 115 27
3000023 - National and Kapodistrian University of Athens (NKUA) - Scho
Athens, 115 27
3000026 - University General Hospital Attikon
Chaïdári, 122 43
3000016 - General Hospital of Thessaloniki "G. Papanikolaou"
Chortiatis, 570 10
3000008 - University of Ioannina School of Medicine - Michaelidion Cardiac Center
Ioannina, 451 10
3000010 - University Hospital of Ioannina
Ioannina, 455 00
3000029 - University of Thessaly- General University Hospital of Laris
Larissa, 41110
3000025 - University General Hospital of Patras
Pátrai, 265 04
3000007 - General Hospital of Nikea "Agios Panteleimon"
Piraeus, 184 54
3000013 - University General Hospital of Thessaloniki AHEPA
Thessaloniki, 546 36
Portugal11 sites
6200011 - Hospital Garcia de Orta, EPE
Almada, 2801-951
6200026 - Centro Hospitalar do Baixo Vouga
Aveiro, 3814-501
6200015 - Hospital de Braga
Braga, 4710-243
6200018 - Centro Hospitalar e Universitário de Coimbra, EPE - Hospitai
Coimbra, 3000-075
6200022 - Centro Hospitalar e Universitário de Coimbra, EPE - Hospital
Coimbra, 3041-801
6200012 - Centro Hospitalar e Universitário do Algarve, EPE - Hospital
Faro, 8000-386
6200021 - Centro Hospitalar do Alto Ave, EPE
Guimarães, 4835-044
6200009 - Hospital de Santo Andre
Leiria, 2410-196
6200014 - Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Santa
Oeiras, 2790
6200025 - Unidade Local de Saude de Matosinhos - Hospital Pedro Hispan
Senhora da Hora, 4460-298
6200017 - Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE - Hospital
Vila Real, 5000-508
Malaysia9 sites
4580015 - Hospital Universiti Sains Malaysia
Kota Bharu, 16150
4580004 - Queen Elizabeth Hospital II
Kota Kinabalu, Sabah, 88300
4580007 - Institut Jantung Negara
Kuala Lumpur, 50400
4580008 - Universiti Kebangsaan Malaysia Medical Centre
Kuala Lumpur, 56000
4580016 - University Malaya Medical Centre
Kuala Lumpur, 59100
4580003 - Hospital Tengku Ampuan Afzan
Kuantan, 25100
4580002 - Hospital Umum Sarawak (HUS) - The Cardiac Centre
Kuching, 94300
4580019 - Hospital Pulau Pinang
Pulau Pinang, 10990
4580005 - Universiti Teknologi MARA (UiTM)
Sungai Buloh, 47000
South Africa9 sites
7100023 - Tread Research
Cape Town, 7500
7100019 - Groote Schuur Hospital
Cape Town, 7925
7100017 - Netcare Union Hospital
Johannesburg, 1449
7100007 - Netcare Unitas Hospital
Lyttelton, Centurion, 0157
7100012 - Netcare Unitas Hospital
Lyttelton, Centurion, 0157
7100006 - Mediclinic Vergelegen
Somerset West, Cape Town, 7130
7100022 - Mediclinic Vergelegen
Somerset West, Cape Town, 7130
7100020 - Netcare Sunninghill Hospital
Sunninghill, 2196
7100010 - Clinical Projects Research SA (Pty) Ltd.
Worcester, 6850
Taiwan9 sites
1580001 - Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807
1580002 - Kaohsiung Veterans General Hospital
Kaohsiung City, 813
1580006 - E-Da Hospital
Kaohsiung City, 82445
1580008 - Mackay Memorial Hospital - Tamsui Branch
New Taipei City, 25160
1580010 - China Medical University Hospital
Taichung, 40447
1580007 - Chi Mei Medical Center
Tainan, 710
1580012 - Cheng Hsin General Hospital
Taipei, Beitou, 112
1580004 - Shin Kong Wu Ho-Su Memorial Hospital
Taipei, 111
1580009 - National Taiwan University Hospital
Zhongzheng, 100
New Zealand8 sites
5540017 - Auckland City Hospital
Auckland, 1023
5540004 - Middlemore Hospital
Auckland, 2025
5540008 - Christchurch Hospital
Christchurch, 8011
5540009 - Dunedin Hospital
Dunedin, 9016
5540005 - Waikato Hospital
Hamilton, 3204
5540007 - Taranaki Base Hospital
New Plymouth, 4310
5540011 - Wellington Hospital
Newtown, Wellington Region, 6021
5540010 - North Shore Hospital
Takapuna, Auckland, 0622
Thailand8 sites
7640012 - Ramathibodi Hospital
Bangkok, 10400
7640021 - Chiang Mai University
Chiang Mai, 50200
7640017 - Khon Kaen University (KKU)
Khon Kaen, 40002
7640018 - Maharat Nakhon Ratchasima Hospital
Nakhon Ratchasima, 30000
7640010 - King Chulalongkorn Memorial Hospital
Pathum Wan, 10330
7640014 - Police General Hospital
Pathum Wan, 10330
7640020 - Buddhachinaraj Hospital Phitsanuloke
Phitsanulok, 65000
7640009 - Songklanagarind Hospital
Songkhla, 90110
Croatia6 sites
1910010 - Županijska Bolnica Cakovec
Čakovec, 40000
1910008 - Specijalna Bolnica za Medicinsku Rehabilitaciju Krapinske Toplice
Krapinske Toplice, 49217
1910019 - Klinicki Bolnicki Centar Rijeka - Susak
Rijeka, 51000
1910003 - Klinicki Bolnicki Centar Zagreb
Zagreb, 01000
1910012 - Klinička Bolnica Sveti Duh
Zagreb, 01000
1910013 - Klinički bolnički centar Sestre milosrdnice
Zagreb, 10000
Austria5 sites
0400035 - Landeskrankenhaus Feldkirch
Feldkirch, 6800
0400020 - LKH-Universität Hospital Graz
Graz, 8036
0400028 - Medizinische Universitaet Innsbruck - Universitaetsklinik für Innere Medizin
Innsbruck, 6020
0400034 - Klinikum Klagenfurt am Wörthersee
Klagenfurt, 9020
0400031 - Universitatsklinik fuer Innere Medizin II, Kardiol
Salzburg, 5020
Chile5 sites
1520014 - Hospital Clinico Regional Dr. Guillermo Grant Benavente
Concepción, 4030000
1520017 - Hospital San Juan de Dios
Santiago, 8350488
1520026 - Hospital Las Higueras
Talcahuano, 4260000
1520004 - Hospital Dr. Hernan Henriquez Aravena
Temuco, 4781151
1520013 - Hospital de Victoria
Victoria, 4720000
Latvia5 sites
4280004 - Daugavpils Regional Hospital
Daugavpils, LV-5417
4280007 - Liepajas Regionala Slimnica
Liepāja, LV-3414
4280008 - Pauls Stradins Clinical University Hospital
Riga, 1007
4280005 - SIA Rigas Austrumu Kliniska Universitates Slimnica - Gaileze
Riga, LV-1038
4280003 - Vidzemes slimnīca
Valmiera, LV-4201
Lithuania5 sites
4400004 - Hospital of Lithuanian University of Health Sciences - Kauno Klinikos
Kaunas, LT-50161
4400007 - Klaipėda Seamen's Hospital
Klaipėda, LT-92288
4400006 - Public Institution Republican Panevezys Hospital
Panevezys, LT-35144
4400008 - Republican Šiauliai Hospital
Šiauliai, LT-76231
4400005 - Vilnius University Hospital Santaros Klinikos
Vilnius, 08661
Slovakia5 sites
7030006 - Univerzitna Nemocnica Bratislava - Nemocnica Staré Mesto
Bratislava, 813 69
7030014 - Univerzitna Nemocnica Bratislava - Nemocnica sv. Cyrila a Me
Bratislava, 851 07
7030013 - Nemocnica Malacky
Malacky, 901 01
7030003 - Kardiocentrum Nitra s.r.o.
Nitra, 949 01
7030002 - Svet zdravia, a.s. - Všeobecná nemocnica Rimavská Sobota
Rimavská Sobota, 979 12
Norway4 sites
5780003 - Akershus Universitetssykehus HF
Lørenskog, 1474
5780011 - Diakonhjemmet Sykehus
Oslo, 0370
5780010 - Sykehuset Telemark HF - Skien
Skien, 3710
5780006 - Helse Stavanger HF
Stavanger, 4011
Sweden4 sites
7520023 - Örebro University Hospital
Örebro, 703 62
7520024 - Ostersunds Sjukhus
Östersund, 831 83
7520011 - Karolinska Universitetssjukhuset - Huddinge
Stockholm, 141 86
7520015 - Västmanlands Sjukhus Västerås
Västerås, 721 89
Estonia3 sites
2330006 - East-Tallinn Central Hospital
Tallinn, 10138
2330005 - North Estonia Medical Centre Foundation
Tallinn, 13419
2330004 - Tartu University Hospital
Tartu, 50406
Hong Kong3 sites
3440004 - Queen Elizabeth Hospital (QEH)
Kowloon, 999077
3440005 - Princess Margaret Hospital
Kwai Chung, 999077
3440006 - Prince of Wales Hospital
Shatin, 999077
Peru3 sites
6040031 - Clínica Internacional - Sede San Borja
Lima, 15036
6040056 - Instituto Nacional Cardiovascular - INCOR
Lima, 15072
6040017 - Clinica El Golf
Lima, 27
Switzerland3 sites
7560025 - University Hospital
Basel, 4056
7560014 - Cardiocentro Ticino
Lugano, 6900
7560019 - Stadtspital Triemli
Zurich, 8055
Finland2 sites
2460006 - Helsinki University Central Hospital (HUCH)
Helsinki, 00290
2460011 - Turku University Hospital (TYKS)
Turku, 20520
Singapore2 sites
7020005 - National University Hospital (S) Pte Ltd
Singapore, 119074
7020006 - National Heart Center Singapore
Singapore, 169609
About this study
Official title: A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects With Acute Coronary Syndrome
This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke] in subjects with acute coronary syndrome (ACS) diagnosed with either ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI), including those managed with percutaneous coronary intervention (PCI) or medically managed.
- Conditions
- Acute Coronary Syndrome
- Being tested
- Apolipoprotein A-I [human] (apoA-I), Placebo
- Keywords
- Coronary Artery Disease, Heart Disease, Cardiovascular Disease, Acute Myocardial Infarction, Heart Failure, Major adverse cardiovascular event, Multivessel disease, Peripheral artery disease, Cerebrovascular accident, Ischemic stroke, Hemorrhagic stroke, Atherosclerosis, Congestive heart failure, Valvular heart disease, Atrial Fibrillation, Hypertension
- Medical subject headings
- Acute Coronary Syndrome, Coronary Artery Disease, Heart Diseases, Cardiovascular Diseases, Heart Failure, Peripheral Arterial Disease, Stroke, Ischemic Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Apolipoprotein A-I [human] (apoA-I)Biological
Also called CSL112
Apolipoprotein A-I [human] (apoA-I) purified from human plasma for intravenous administration
PlaceboOther
25% albumin solution diluted to 4.4%
| Study group | Role | What they receive |
|---|---|---|
| CSL112 | Experimental | Apolipoprotein A-I [human] Receives: Biological: Apolipoprotein A-I [human] (apoA-I) |
| Placebo | Placebo comparator | 25% albumin solution diluted to 4.4% Receives: Other: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of Participants With First Occurrence of Any Component of Composite MACE (CV Death, MI, or Stroke)
MACE (Major adverse cardiovascular event[s])(CV [cardiovascular] death, MI [Myocardial Infarction], or stroke).
Measured: From the time of randomization through 90 days
Secondary outcomes (24)
Total Number of Hospitalizations for Coronary, Cerebral, and Peripheral Ischemia
The total number of hospitalizations and individual hospitalizations due to coronary, cerebral, and peripheral ischemia were reported.
Measured: From the time of randomization through 90 days
Number of Participants With First Occurrence of CV Death, MI, or Stroke
Measured: From the time of randomization through 180 days
Number of Participants With First Occurrence of CV Death, MI, or Stroke
Measured: From the time of randomization through 365 days
Number of Participants With Occurrence of CV Death
Measured: From the time of randomization through 90 days
Number of Participants With First Occurrence of MI
Measured: From the time of randomization through 90 days
Number of Participants With First Occurrence of Stroke
Measured: From the time of randomization through 90 days
Number of Participants With First Occurrence of CV Death, Type 1 MI or Stroke
Measured: From the time of randomization through 90, 180 and 365 days
Number of Participants With Occurrence of All-cause Death
Measured: From the time of randomization through 365 days
Number of Participants With Adverse Events
An AE was defined as any unfavorable and unintended sign (including an abnormal, clinically significant laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not considered related to the medicinal (investigational) product.
Measured: From the start of treatment through 90 days
Percentage of Participants With Adverse Events
An AE was defined as any unfavorable and unintended sign (including an abnormal, clinically significant laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not considered related to the medicinal (investigational) product.
Measured: From the start of treatment through 90 days
Number of Participants With Treatment-related Adverse Events
Treatment-related AEs were AEs considered by the Investigator to have a causal relationship to the investigational product.
Measured: From the start of treatment through 379 days (Day 365 + 14 days of follow up)
Percentage of Participants With Treatment-related Adverse Events
Treatment-related AEs were AEs considered by the Investigator to have a causal relationship to the investigational product. As per the study statistical analysis plan (SAP), descriptive percentages were displayed to one decimal place, hence the percentage values were rounded off and presented.
Measured: From the start of treatment through 379 days (Day 365 + 14 days of follow up)
Number of Participants With Serious Adverse Events (SAEs)
SAE was defined as any untoward medical occurrence that at any dose: results in death, is life-threatening, requires in-patient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability or incapacity, is a congenital anomaly or birth defect, or is a medically significant event.
Measured: From the start of treatment through 379 days (Day 365 + 14 days of follow up)
Percentage of Participants With SAEs
SAE was defined as any untoward medical occurrence that at any dose: results in death, is life-threatening, requires in-patient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability or incapacity, is a congenital anomaly or birth defect or is a medically significant event. As per the study SAP, descriptive percentages were displayed to one decimal place, hence the percentage values were rounded off and presented.
Measured: From the start of treatment through 379 days (Day 365 + 14 days of follow up)
Number of Participants With a Shift From Baseline to Worst Post-treatment Value in Clinical Laboratory Assessments
Clinical laboratory assessments included assessment of Hematology (hemoglobin, hematocrit, leukocytes and platelets) and Biochemistry (alkaline phosphatase [ALP], alanine aminotransferase [ALT], aspartate aminotransferase [AST], bilirubin, direct bilirubin, indirect bilirubin and estimated glomerular filtration rate [eGFR]). The number of participants with a shift from the Baseline value to the worst post-treatment value (low, normal, or high) was reported. The worst criterion for the parameters is as follows: hematocrit - low, hemoglobin - low, leukocytes - high, platelets - low, ALT - high, ALP - high, AST - high, bilirubin - high, direct bilirubin - high, indirect bilirubin - high, eGFR - severe impairment.
Measured: Baseline and 29 days
Percentage of Participants With a Shift From Baseline to Worst Post-treatment Value in Clinical Laboratory Assessments
Clinical laboratory assessments included assessment of Hematology (hemoglobin, hematocrit, leukocytes and platelets) and Biochemistry (ALP, ALT, AST, bilirubin, direct bilirubin, indirect bilirubin and eGFR). Percentage of participants with a shift from the Baseline value to the worst post-treatment value (low, normal, or high) was reported. The worst criterion for the parameters is as follows: hematocrit - low, hemoglobin - low, leukocytes - high, platelets - low, ALT - high, ALP - high, AST - high, bilirubin - high, direct bilirubin - high, indirect bilirubin - high, eGFR - severe impairment. As per the study SAP, descriptive percentages were displayed to one decimal place, hence the percentage values were rounded off and presented.
Measured: Baseline and 29 days
Change From Baseline in Hematology Parameters
Hematology parameters included Basophils, Eosinophils, Leukocytes, Lymphocytes, Monocytes, Neutrophils and Platelets.
Measured: From Baseline to Day 29
Change From Baseline in Hematology Parameter: Hematocrit
Measured: From Baseline to Day 29
Change From Baseline in Hematology Parameter: Hemoglobin
Measured: From Baseline to Day 29
Change From Baseline in Hepatic Parameters
Hepatic parameters included ALT, ALP and AST.
Measured: From Baseline to Day 29
Change From Baseline in Hepatic Parameter: Bilirubin
Measured: From Baseline to Day 29
Change From Baseline in Renal Parameter: Serum Creatinine
Measured: From Baseline to Day 29
Change From Baseline in Renal Parameter: eGFR
Measured: From Baseline to Day 29
Change From Baseline in Renal Parameter: Blood Urea Nitrogen
Measured: From Baseline to Day 29
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Mar 2018
- Study start21 Mar 2018
- Primary completion16 Feb 2023
- Study completion17 Nov 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Acute Coronary SyndromeStudies of the same condition, open and under way.
- More trials run by CSL BehringThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 18,226 participants (actual)
Sponsor and investigators
- Lead sponsor
- CSL Behring
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Danielle Duffy, MD, Study director, CSL Behring - Executive Director, Clinical Development - CV & Metabolism
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03473223
- Sponsor's protocol ID
- CSL112_3001
- Other IDs
- 2017-000996-98, 2017
- Acronym
- AEGIS-II
- Status last verified
- Dec 2024
- First submitted
- 14 Mar 2018
- Last updated
- 14 Jan 2025
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Gibson CM, Duffy D, Korjian S, Bahit MC, Chi G, Alexander JH, Lincoff AM, Heise M, Tricoci P, Deckelbaum LI, Mears SJ, Nicolau JC, Lopes RD, Merkely B, Lewis BS, Cornel JH, Trebacz J, Parkhomenko A, Libby P, Sacks FM, Povsic TJ, Bonaca M, Goodman SG, Bhatt DL, Tendera M, Steg PG, Ridker PM, Aylward P, Kastelein JJP, Bode C, Mahaffey KW, Nicholls SJ, Pocock SJ, Mehran R, Harrington RA; AEGIS-II Committees and Investigators. Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction. N Engl J Med. 2024 May 2;390(17):1560-1571. doi: 10.1056/NEJMoa2400969. Epub 2024 Apr 6.
PubMed 38587254Povsic TJ, Korjian S, Bahit MC, Chi G, Duffy D, Alexander JH, Vinereanu D, Tricoci P, Mears SJ, Deckelbaum LI, Bonaca M, Ridker PM, Goodman SG, Cornel JH, Lewis BS, Parkhomenko A, Lopes RD, Aylward P, Lincoff AM, Heise M, Sacks F, Nicolau JC, Merkely B, Trebacz J, Libby P, Nicholls SJ, Pocock S, Bhatt DL, Kastelein J, Bode C, Mahaffey KW, Steg PG, Tendera M, Bainey KR, Harrington RA, Mehran R, Duerschmied D, Kingwell BA, Gibson CM; AEGIS-II Committees and Investigators. Effect of Reconstituted Human Apolipoprotein A-I on Recurrent Ischemic Events in Survivors of Acute MI. J Am Coll Cardiol. 2024 Jun 4;83(22):2163-2174. doi: 10.1016/j.jacc.2024.03.396. Epub 2024 Apr 6.
PubMed 38588930Gibson CM, Chi G, Duffy D, Bahit MC, White H, Korjian S, Alexander JH, Lincoff AM, Anschuetz G, Girgis IG, Nicolau JC, Lopes RD, Cornel JH, Bainey KR, Libby P, Sacks FM, Ridker PM, Goodman SG, Mahaffey KW, Nicholls SJ, Pocock SJ, Mehran R, Harrington RA; AEGIS-II Committees and Investigators. ApoA-I Infusions and Burden of Ischemic Events After Acute Myocardial Infarction: Insights From the AEGIS-II Trial. J Am Coll Cardiol. 2024 Nov 26;84(22):2185-2192. doi: 10.1016/j.jacc.2024.08.001. Epub 2024 Sep 2.
PubMed 39230545Gibson CM, Duffy D, Bahit MC, Chi G, White H, Korjian S, Alexander JH, Lincoff AM, Heise M, Kingwell BA, Nicolau JC, Lopes RD, Cornel JH, Lewis BS, Vinereanu D, Goodman SG, Bode C, Steg PG, Libby P, Sacks FM, Bainey KR, Ridker PM, Mahaffey KW, Aylward P, Nicholls SJ, Pocock SJ, Mehran R, Harrington RA; AEGIS-II Committees and Investigators. Apolipoprotein A-I infusions and cardiovascular outcomes in acute myocardial infarction according to baseline LDL-cholesterol levels: the AEGIS-II trial. Eur Heart J. 2024 Dec 16;45(47):5023-5038. doi: 10.1093/eurheartj/ehae614.
PubMed 39221651