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Endocrine TumoreurocrineNCT03410394

Registry of Endocrine Tumors (Thyroid, Parathyroid, Adrenal, Endocrine Pancreas, Endocrine Digestive Tube)

An observational study of Endocrine Tumor, run by Central Hospital, Nancy, France at 1 site in France.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

This registry aims to collect informations about patients with endocrine tumors (Thyroid, Parathyroid, Adrenal, Endocrine Pancreas, Endocrine Digestive Tube) who undergo endocrine surgical procedures. This registry is part of the Eurocrine Project. Read more about this study

Who is it for?
Any age
Conditions the study is for
Endocrine Tumor
How many people
3,000 participants
Where
1 siteFrance
Study dates
1 Jan 2015to 1 Jan 2030
How long will I take part?
10 Years
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages Any age
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

Study population: patients who undergo surgical procedures for endocrine tumors at CHU Nancy Brabois (University hospital)

Who may be able to join

  • patients who undergo surgical procedures for endocrine tumors at the University Nancy Brabois Hospital

Who cannot join

  • unable to receive clear information
  • refusal to sign the consent form

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

laurent Brunaud, MD, PhD contact

l.brunaud@chru-nancy.fr

Brunaud contact

l.brunaud@chru-nancy.fr

France1 site, 1 recruiting

  • CHU Nancy

    Vandœuvre-lès-Nancy, 54511

    laurent Brunaud, l.brunaud@chu-nancy.fr

    Recruiting

Other trials in France

About this study

Official title: Registre Tumeurs Endocrine - Eurocrine

This registry aims to collect informations about patients with endocrine tumors (Thyroid, Parathyroid, Adrenal, Endocrine Pancreas, Endocrine Digestive Tube) who undergo endocrine surgical procedures. This registry is part of the Eurocrine Project.

Read the detailed description

The EUROCRINE project aims to decrease morbidity and mortality of rare endocrine tumours, by means of a pan-European database. Recording and accessing data at the European level, makes it possible to identify these tumours, which cannot be distinguished at local or national level, because of their extreme rarity. Dissemination of results aims to raise clinical standards and reduce differences in practise between clinics and member states, and thereby diminish morbidity and mortality. Comparison of practice and outcomes will be especially interesting for centres wanting to improve their standards to what is currently considered best practice. EUROCRINE will be a key means by which the medical profession, researchers, health policy makers, and not least patients, can benefit from an increase in knowledge related to diagnosis, treatment, and future clinical research in the field of rare endocrine tumours.

Conditions
Endocrine Tumor
Keywords
adrenal, thyroid, parathyroid, endocrine pancreas, endocrine digestive tube
Medical subject headings
Endocrine Gland Neoplasms, Thyroid Diseases

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT03410394
Study groupRoleWhat they receive
registry of endocrine tumors* Patients who undergo thyroid surgical procedures. This registry was declared at the commission national informatique et libertés (CNIL) with the number R2015-22. * Patients who undergo parathyroid surgical procedures. This registry was declared at the commission national informatique et libertés (CNIL) with the number R2015-23 * Patients who undergo adrenal surgical procedures. This registry was declared at the commission national informatique et libertés (CNIL) with the number R2015-24 * Patients who undergo pancreatic and digestive surgical procedures. This registry was declared at the commission national informatique et libertés (CNIL) with the number R2015-26

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Postoperative complications (endocrine surgical procedure)

    morbidity rate in percentage (%)

    Measured: 12 months after surgical procedure

Secondary outcomes (13)

  1. Postoperative complications severity (endocrine surgical procedure)

    Dindo-Clavien classification in percentage (%)

    Measured: 12 months after surgical procedure

  2. Postoperative mortality (endocrine surgical procedure)

    mortality rate in percentage (%)

    Measured: 12 months after surgical procedure

  3. CT imaging before endocrine surgical procedure (Tumor characteristics)

    Density in Hounsfield unit (HU)

    Measured: Baseline

  4. CT imaging before endocrine surgical procedure (Coronary artery score)

    CAC score in Agatston score unit (HU)

    Measured: Baseline

  5. CT imaging before endocrine surgical procedure (Sarcopenia)

    Evaluation of sarcopenia using L3 skeletal muscle index (in cm²/m²)

    Measured: preoperative period

  6. Bone mineral density

    dual-energy x-ray absorptiometry (DEXA) (in T-score unit)

    Measured: Baseline

  7. Intraoperative systolic arterial pressure

    systolic arterial pressure (in mmHg)

    Measured: Intraoperative

  8. Intraoperative diastolic arterial pressure

    diastolic arterial pressure (in mmHg)

    Measured: Intraoperative

  9. Parathormone plasma levels

    Parathormone (in pg/mL)

    Measured: Baseline and up to 12 months after surgical procedure

  10. Aldosterone plasma levels

    Aldosterone (in pmol/L)

    Measured: Baseline and up to 12 months after surgical procedure

  11. Plasma renin activity

    Renin (in μIU/mL)

    Measured: Baseline and up to 12 months after surgical procedure

  12. Plasma free metanephrines

    metanephrines (in nmol/L)

    Measured: Baseline and up to 12 months after surgical procedure

  13. PET scanning

    standardized uptake values (SUV tumor / SUV liver ratio)

    Measured: Baseline

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted25 Jan 2018
  2. Study start1 Jan 2015
  3. Primary completion1 Jan 2030 (estimated)
  4. Study completion1 Jan 2030 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
3,000 participants (estimated)
Target duration
10 Years
IDs, dates and publications
ClinicalTrials.gov ID
NCT03410394
Sponsor's protocol ID
N° CCTIRS :15.291 Version N°3
Acronym
eurocrine
Status last verified
Oct 2026
First submitted
10 Jan 2018
Last updated
22 Oct 2026
Results posted
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Remond A, Marciniak C, Lenne X, Chouraki V, Gobert M, Baud G, Maillard L, Bouriez D, Liekens E, Donatini G, Nomine-Criqui C, Ravenet A, Santucci N, Kuczma P, Bouviez N, Tresallet C, Mirallie E, Deguelte S, Brunaud L, Guerin C, Gronnier C, Lifante JC, Bruandet A, Theis D, Cortot A, Scherpereel A, Hamroun A, Pattou F, Caiazzo R. Survival and Prognostic Factors After Adrenalectomy for Secondary Malignancy: A Combined Analysis of a French University Center Registry (Eurocrine) of 307 Patients and a French Nationwide Study of 2515 Patients. Ann Surg. 2024 Nov 1;280(5):825-834. doi: 10.1097/SLA.0000000000006479. Epub 2024 Aug 7.

    PubMed 39109429

  • Greilsamer T, Nomine-Criqui C, Thy M, Ullmann T, Zarnegar R, Bresler L, Brunaud L. Robotic-assisted unilateral adrenalectomy: risk factors for perioperative complications in 303 consecutive patients. Surg Endosc. 2019 Mar;33(3):802-810. doi: 10.1007/s00464-018-6346-2. Epub 2018 Jul 11.

    PubMed 29998394

Questions about this trial

What is this clinical trial studying?

An observational study of Endocrine Tumor, run by Central Hospital, Nancy, France at 1 site in France.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 22 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact laurent Brunaud, MD, PhD (l.brunaud@chru-nancy.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Postoperative complications (endocrine surgical procedure) (time frame: 12 months after surgical procedure). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT03410394, which also lists 2 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Oct 2026.

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