Sport InjuryHAMMERNCT03373084
Imaging Location of Hamstring Muscle Lesions in Sport and Relationships With Injury Mechanism.
An observational study of Sport Injury and Hamstring Muscle Lesions, run by Centre Hospitalier Universitaire de Saint Etienne at 1 site in France.
Trial summary
Hamstring muscle injuries are a common pathology in sports mainly present in sprint and acceleration sports, accounting for about 12% of all football injuries. Because of their frequency, risk of reinjury and financial cost, they can be considered as a public health problem. Read more about this study
- Who is it for?
- Ages 18 to 50 years
- Conditions the study is for
- Sport Injury, Hamstring Muscle Lesions
- What is being tested?
- Magnetic Resonance Imaging (MRI), ultrasound and Self-questionnaire
- How many people
- 88 participants
- Where
- 1 siteFrance
- Study dates
- 14 Feb 2018to 27 Jan 2023
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- No healthy volunteers
- Adult
Study population: Athletics with thigh injury will be included.
Who may be able to join
- To be recreational sportsmen, competitions, amateurs, high-level or professional
- Aged 18 to 50 years
- Perform an Magnetic Resonance Imaging (MRI) or an ultrasound of the thigh in the context of the suspicion of an acute hamstring muscle injury
- Injury during sport since less 21 days old.
Who cannot join
- a history of surgery of the anterior cruciate ligament with removal of the transplant in the posterior compartment of the thigh
- an antecedent of surgery of the thigh.
- inability to understand the French language for completing the self-questionnaire
Trial locations and contacts
1 site in 1 country.
About this study
Hamstring muscle injuries are a common pathology in sports mainly present in sprint and acceleration sports, accounting for about 12% of all football injuries. Because of their frequency, risk of reinjury and financial cost, they can be considered as a public health problem. Improving knowledge of the pathophysiology of hamstring muscle injury appears to be a relevant research focus for prevention purposes.
Read the detailed description
This study is a cohort of athletes in the context of suspicion of hamstring muscle injuries.
- Conditions
- Sport Injury, Hamstring Muscle Lesions
- Being tested
- Magnetic Resonance Imaging (MRI), ultrasound, Self-questionnaire
- Keywords
- Magnetic Resonance Imaging (MRI), Ultrasound, Sport, Hamstring muscle, Injury
- Medical subject headings
- Wounds and Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Magnetic Resonance Imaging (MRI)Other
Magnetic Resonance Imaging (MRI) or ultrasound will be performed to determinate location of the lesion
ultrasoundOther
Magnetic Resonance Imaging (MRI) or ultrasound will be performed to determinate location of the lesion
Self-questionnaireOther
Self-questionnaire will be completed by patient. In this questionnaire patients will describe the circumstances of the injury and their personal characteristics and level of sporting practice.
| Study group | Role | What they receive |
|---|---|---|
| hamstring muscle lesions | Patients with hamstring muscle lesions in sport will be included. As usual practice they will have Magnetic Resonance Imaging (MRI) or ultrasound, and will answer to self-questionnaire Receives: Other: Magnetic Resonance Imaging (MRI); Other: ultrasound; Other: Self-questionnaire |
What is being measured
The primary outcome is the main question the study is designed to answer.
location of the lesion of injury
Correlation between location of the lesion and mechanism of onset of injury. Location of the lesion will be measured by Magnetic Resonance Imaging (MRI) or ultrasound results. For location of the lesion, it is a combination of the injured muscle, damaged tissue and the area in the posterior compartment of the thigh.
Measured: at inclusion
mechanism of onset of injury
Correlation between location of the lesion and mechanism of onset of injury. Location of the lesion will be measured by Magnetic Resonance Imaging (MRI) or ultrasound results.
Mechanism of onset of injury will be check by self-questionnaire.
Measured: at inclusion
Secondary outcomes (2)
mapping of hamstring lesions
Analyzed of mapping of hamstring lesions with Magnetic Resonance Imaging (MRI) / ultrasound.
Compare the MRI and ultrasound maps and the performance of the two means to determine the location of the lesion.
Measured: at inclusion
volumetric analysis of the hamstrings
A standardization of the images to allow a better comparison between individuals
Measured: at inclusion
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Dec 2017
- Study start14 Feb 2018
- Primary completion27 Jan 2023
- Study completion27 Jan 2023
Why it stopped: Reduced recruitment potential for study participants.
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Sport InjuryStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire de Saint EtienneThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 88 participants (actual)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Pascal EDOUARD, MD, Principal investigator, Centre Hospitalier Universitaire de Saint Etienne
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03373084
- Sponsor's protocol ID
- 1708231
- Other IDs
- ANSM
- Acronym
- HAMMER
- Status last verified
- Oct 2024
- First submitted
- 11 Dec 2017
- Last updated
- 10 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Grange S, Plancher R, Reurink G, Croisille P, Edouard P. Relationship Between the Pain Intensity at the Time of the Hamstring Muscle Injury and the Hyperintense T2 Weighted Volume of the Hamstring Muscle Lesion Measured by MRI. Clin J Sport Med. 2025 Mar 1;35(2):113-118. doi: 10.1097/JSM.0000000000001306. Epub 2024 Dec 24.
PubMed 39718376Grange S, Reurink G, Croisille P, Edouard P. Relationship Between Patients' Self-Reported Injury Mechanism and MRI Outcomes in Hamstring Muscle Injury: A Prospective Cohort Study on 71 Patients. Sports Health. 2026 May-Jun;18(3):559-568. doi: 10.1177/19417381251343070. Epub 2025 Jun 12.
PubMed 40506866
Study at a glance
From the registry record, last updated by the sponsor on 10 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Imaging Location of Hamstring Muscle Lesions in Sport and Relationships With Injury Mechanism.
- ClinicalTrials.gov ID
- NCT03373084
- Acronym / sponsor ID
- HAMMER / 1708231
- Conditions
- Sport Injury, Hamstring Muscle Lesions
- Keywords
- Magnetic Resonance Imaging (MRI), Ultrasound, Sport, Hamstring muscle, Injury
- Study type
- Observational
- Recruitment status
- TerminatedReason stopped: Reduced recruitment potential for study participants.
- Enrolment
- 88 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire de Saint EtienneUniversity, hospital or other
- Study start
- 14 Feb 2018 (actual)
- Primary completion
- 27 Jan 2023 (actual)
- Study completion
- 27 Jan 2023 (actual)
- First posted
- 14 Dec 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Hamstring muscle injuries are a common pathology in sports mainly present in sprint and acceleration sports, accounting for about 12% of all football injuries. Because of their frequency, risk of reinjury and financial cost, they can be considered as a public health problem. Improving knowledge of the pathophysiology of hamstring muscle injury appears to be a relevant research focus for prevention purposes.
Detailed description
This study is a cohort of athletes in the context of suspicion of hamstring muscle injuries.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| hamstring muscle lesions | – | Other: Magnetic Resonance Imaging (MRI), Other: ultrasound, Other: Self-questionnairePatients with hamstring muscle lesions in sport will be included. As usual practice they will have Magnetic Resonance Imaging (MRI) or ultrasound, and will answer to self-questionnaire |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- Athletics with thigh injury will be included.
Key inclusion criteria (4 listed)
- To be recreational sportsmen, competitions, amateurs, high-level or professional
- Aged 18 to 50 years
- Perform an Magnetic Resonance Imaging (MRI) or an ultrasound of the thigh in the context of the suspicion of an acute hamstring muscle injury
- Injury during sport since less 21 days old.
Key exclusion criteria (3 listed)
- a history of surgery of the anterior cruciate ligament with removal of the transplant in the posterior compartment of the thigh
- an antecedent of surgery of the thigh.
- inability to understand the French language for completing the self-questionnaire
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Magnetic Resonance Imaging (MRI)Magnetic Resonance Imaging (MRI) or ultrasound will be performed to determinate location of the lesion | Other | hamstring muscle lesions |
| ultrasoundMagnetic Resonance Imaging (MRI) or ultrasound will be performed to determinate location of the lesion | Other | hamstring muscle lesions |
| Self-questionnaireSelf-questionnaire will be completed by patient. In this questionnaire patients will describe the circumstances of the injury and their personal characteristics and level of sporting practice. | Other | hamstring muscle lesions |
Primary outcome
location of the lesion of injury
Time frame: at inclusion
Correlation between location of the lesion and mechanism of onset of injury. Location of the lesion will be measured by Magnetic Resonance Imaging (MRI) or ultrasound results. For location of the lesion, it is a combination of the injured muscle, damaged tissue and the area in the posterior compartment of the thigh.
mechanism of onset of injury
Time frame: at inclusion
Correlation between location of the lesion and mechanism of onset of injury. Location of the lesion will be measured by Magnetic Resonance Imaging (MRI) or ultrasound results. Mechanism of onset of injury will be check by self-questionnaire.
2 secondary outcomes
mapping of hamstring lesions
Time frame: at inclusion
volumetric analysis of the hamstrings
Time frame: at inclusion
Results and safety
The study was stopped early (reason given: Reduced recruitment potential for study participants.). Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jul 2026.
- Results publication: PubMed 39718376Grange S, Plancher R, Reurink G, Croisille P, Edouard P. Relationship Between the Pain Intensity at the Time of the Hamstring Muscle Injury and the Hyperintense T2 Weighted Volume of the Hamstring Muscle Lesion Measured by MRI. Clin J Sport Med. 2025 Mar 1;35(2):113-118. doi: 10.1097/JSM.0000000000001306. Epub 2024 Dec 24.
- Results publication: PubMed 40506866Grange S, Reurink G, Croisille P, Edouard P. Relationship Between Patients' Self-Reported Injury Mechanism and MRI Outcomes in Hamstring Muscle Injury: A Prospective Cohort Study on 71 Patients. Sports Health. 2026 May-Jun;18(3):559-568. doi: 10.1177/19417381251343070. Epub 2025 Jun 12.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Pascal EDOUARD, MD principal investigator
Centre Hospitalier Universitaire de Saint Etienne
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Sport Injury and Hamstring Muscle Lesions, run by Centre Hospitalier Universitaire de Saint Etienne at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 10 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was stopped early (reason given: Reduced recruitment potential for study participants.). Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
location of the lesion of injury (time frame: at inclusion). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03373084, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jul 2026.