Healthy VolunteersPPCfonctionsNCT03286686
Sensori-motor and Perceptual Functions of the PPC.
A study testing point targets, tactile stimulation and visual images in people with Healthy Volunteers and Optic Ataxia, run by Hospices Civils de Lyon at 1 site in France.
Trial summary
To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception. The posterior parietal cortex (PPC) is a region of the cortex involved in this multisensory integration. Read more about this study
- Who is it for?
- Ages 18 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Volunteers, Optic Ataxia
- What is being tested?
- point targets, tactile stimulation and visual images
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 160 participants
- Where
- 1 siteFrance
- Study dates
- 22 Feb 2018to 22 Feb 2031
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- All patients and healthy subjects:
- male and female, age from 18 to 75 years included
- normal vision or corrected vision
- covered by social security
- signed written informed consent
- Patients:
Show all 9Show fewer
- neurological injury in posterior parietal cortex supported by a cerebral MRI
- present optic ataxia symptoms Healthy subjects
- no known neurological injury
Who cannot join
- unable to comply with the tasks (neurological, psychiatric, sensory or motor troubles)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
U1028 INSERM - CNRS UMR 5292 Equipe ImpAct
Bron, 69500
Laure Pisella, PhD, 4 72 91 34 05 ext. +33, laure.pisella@inserm.fr
Laure Pisella, PhD
About this study
Official title: Sensori-motor and Perceptual Functions of the Posterior Parietal Cortex (PPC) in Patients With Optic Ataxia (AO) and Healthy Subjects.
To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception. The posterior parietal cortex (PPC) is a region of the cortex involved in this multisensory integration. A lesion of the PPC cause a visuo-motor trouble called optic ataxia but these patients also have perceptual troubles.
The aim of the study is to understand the different functions of the PPC and especially how the processes of spatial coding of the sensory information influences perception and motor planning.
Read more
In this study, the investigator want to explore the sensory motor and the perceptual performance of patients with optic ataxia compared with healthy subjects, using 6 behavioral tests.
Objectify the consequences of PPC impairment (visual-motor and perceptual consequences) on patients' quality of life and autonomy.
- Conditions
- Healthy Volunteers, Optic Ataxia
- Being tested
- point targets, tactile stimulation, visual images
- Keywords
- optic ataxia, posterior parietal cortex functions, multisensory integration
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
point targetsBehavioural
In the experiences 1 and 2, the participant needs to point different visual targets (LED) in the dark.
tactile stimulationBehavioural
In the experience 3, a tactile stimulation is applied to the middle finger of the 2 hands. The participant needs to indicate into a microphone when he feels the stimulation.
visual imagesBehavioural
Target dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected.
| Study group | Role | What they receive |
|---|---|---|
| Experience 1 | Experimental | Not described Receives: Behavioral: point targets |
| Experience 2 | Experimental | Not described Receives: Behavioral: point targets |
| Experience 3 | Experimental | Not described Receives: Behavioral: tactile stimulation |
| Experience 4 | Experimental | Not described Receives: Behavioral: visual images |
| Experience 5 | Experimental | Not described Receives: Behavioral: visual images |
| Experience 6 | Experimental | Not described Receives: Behavioral: visual images |
What is being measured
The primary outcome is the main question the study is designed to answer.
response error - number of pointing error
Measured: Day 0 after each stimulation
response error -measure of reaction times
Measured: Day 0 after each stimulation
response error - percentage of right responses
Measured: Day 0 after each stimulation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Sep 2017
- Study start22 Feb 2018
- Primary completion22 Feb 2031 (estimated)
- Study completion22 Feb 2031 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy VolunteersStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 160 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Laure PISELLA, PhD, Principal investigator, INSERM U1028 - Impact - CRNL
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03286686
- Sponsor's protocol ID
- 69HCL17_0341
- Other IDs
- 2017-A02562-51
- Acronym
- PPCfonctions
- Status last verified
- Jan 2026
- First submitted
- 14 Sep 2017
- Last updated
- 20 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 20 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Sensori-motor and Perceptual Functions of the Posterior Parietal Cortex (PPC) in Patients With Optic Ataxia (AO) and Healthy Subjects.
- ClinicalTrials.gov ID
- NCT03286686
- Acronym / sponsor ID
- PPCfonctions / 69HCL17_0341
- Conditions
- Healthy Volunteers, Optic Ataxia
- Keywords
- optic ataxia, posterior parietal cortex functions, multisensory integration
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 160 participants (estimated)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 22 Feb 2018 (actual)
- Primary completion
- 22 Feb 2031 (estimated)
- Study completion
- 22 Feb 2031 (estimated)
- First posted
- 18 Sep 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception. The posterior parietal cortex (PPC) is a region of the cortex involved in this multisensory integration. A lesion of the PPC cause a visuo-motor trouble called optic ataxia but these patients also have perceptual troubles.
The aim of the study is to understand the different functions of the PPC and especially how the processes of spatial coding of the sensory information influences perception and motor planning.
In this study, the investigator want to explore the sensory motor and the perceptual performance of patients with optic ataxia compared with healthy subjects, using 6 behavioral tests.
Objectify the consequences of PPC impairment (visual-motor and perceptual consequences) on patients' quality of life and autonomy.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 6
| Arm | Type | Receives |
|---|---|---|
| Experience 1 | Experimental | Behavioral: point targets |
| Experience 2 | Experimental | Behavioral: point targets |
| Experience 3 | Experimental | Behavioral: tactile stimulation |
| Experience 4 | Experimental | Behavioral: visual images |
| Experience 5 | Experimental | Behavioral: visual images |
| Experience 6 | Experimental | Behavioral: visual images |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- male and female, age from 18 to 75 years included
- normal vision or corrected vision
- covered by social security
- signed written informed consent
- neurological injury in posterior parietal cortex supported by a cerebral MRI
Key exclusion criteria (1 listed)
- unable to comply with the tasks (neurological, psychiatric, sensory or motor troubles)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| point targetsIn the experiences 1 and 2, the participant needs to point different visual targets (LED) in the dark. | Behavioural | Experience 1, Experience 2 |
| tactile stimulationIn the experience 3, a tactile stimulation is applied to the middle finger of the 2 hands. The participant needs to indicate into a microphone when he feels the stimulation. | Behavioural | Experience 3 |
| visual imagesTarget dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected. | Behavioural | Experience 4, Experience 5, Experience 6 |
Primary outcome
response error - number of pointing error
Time frame: Day 0 after each stimulation
response error -measure of reaction times
Time frame: Day 0 after each stimulation
response error - percentage of right responses
Time frame: Day 0 after each stimulation
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jan 2026.
- Individual participant dataSharing planned: Undecided
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Screening Protocol
Pain
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Laure PISELLA, PhD principal investigator
INSERM U1028 - Impact - CRNL
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing point targets, tactile stimulation and visual images in people with Healthy Volunteers and Optic Ataxia, run by Hospices Civils de Lyon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Laure PISELLA, PhD (4 72 91 34 05 ext. +33, laure.pisella@inserm.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
response error - number of pointing error (time frame: Day 0 after each stimulation). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jan 2026.