AzTrials
AzTrials

Heart FailurePhase 3NCT03057951

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)

A Phase 3 study testing Empagliflozin in people with Heart Failure, run by Boehringer Ingelheim at 619 sites in 23 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

This is a study in adults with chronic heart failure. People with chronic heart failure may need to be hospitalised for their condition. Some people with chronic heart failure may eventually die from their condition. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Heart Failure
What is being tested?
Empagliflozin
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
5,988 participants
Where
619 sitesin 23 countries
Study dates
2 Mar 2017to 26 Apr 2021
Phase
Phase 3
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Male or female patient, age >= 18 years at screening. For Japan only: Age >=20 years at screening
  • Patients with chronic HF (Chronic Heart Failure) NYHA (New York Heart Association classification) class II-IV and preserved EF (Ejection Fraction)(LVEF (Left Ventricular Ejection Fraction) > 40 %) and elevated NT-proBNP (N-terminal of the prohormone brain natriuretic peptide) > 300 pg/ml for patients without AF, OR > 900 pg/ml for patients with AF, analysed at the Central laboratory at Visit 1
  • Structural heart disease within 6 months prior to Visit 1, OR documented HHF (Hospitalisation for Heart Failure) within 12 months prior to Visit 1
  • Stable dose of oral diuretics, if prescribed
  • Signed and dated written ICF (informed consent form)
  • Further inclusion criteria apply

Who cannot join

  • Myocardial infarction, coronary artery bypass graft surgery or other major cardiovascular surgery, stroke or TIA (Transient Ischaemic Attack) in past 90 days prior to Visit 1
  • Heart transplant recipient or listed for heart transplant
  • Acute decompensated HF (Heart Failure)
  • Systolic blood pressure (SBP) >= 180 mmHg at Visit 2.
  • Symptomatic hypotension and/or a SBP < 100 mmHg
  • Indication of liver disease,
Show all 13Show fewer
  • Impaired renal function, defined as eGFR (Estimated Glomerular Filtration Rate) < 20 mL/min/1.73 m2 (CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration Equation))cr or requiring dialysis
  • History of ketoacidosis
  • Current use or prior use of a SGLT (Sodium-glucose co-transporter) -2 inhibitor or combined SGLT-1 and 2 inhibitor
  • Currently enrolled in another investigational device or drug trial
  • Known allergy or hypersensitivity to empagliflozin or other SGLT-2 inhibitors
  • Women who are pregnant, nursing, or who plan to become pregnant while in the trial
  • Further exclusion criteria may apply

Trial locations and contacts

619 sites in 23 countries.

619 sites in 23 countries

United States135 sites

  • Capital Cardiology Associates, PC

    Albany, New York, 12211

  • Alpena General Hospital

    Alpena, Michigan, 49707

  • Anne Arundel Medical Center

    Annapolis, Maryland, 21401

  • Pinnacle Research Group, LLC

    Anniston, Alabama, 36207

  • Northwest Heart Clinical Research, LLC

    Arlington Heights, Illinois, 60005

  • Asheville Cardiology Associates

    Asheville, North Carolina, 28803

  • Grady Clinical Research Center

    Atlanta, Georgia, 30303

  • Seton Heart Institute

    Austin, Texas, 78705

  • Maryland Cardiovascular Specialists

    Baltimore, Maryland, 21229

  • MedStar Health Research Institute

    Baltimore, Maryland, 21237

  • Metropolitan Cardiovascular Consultants

    Beltsville, Maryland, 20705

  • Deaconess Billings Clinic Research Center

    Billings, Montana, 59101

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35249

  • Integrated Heart Care

    Boca Raton, Florida, 33434

  • Grace Research, LLC

    Bossier City, Louisiana, 71111

  • Tufts Medical Center

    Boston, Massachusetts, 02111

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114

  • Bozeman Health Clinical Research

    Bozeman, Montana, 59718

  • Advanced Heart Care, LLC

    Bridgewater, New Jersey, 08807

  • Kernodle Clinic West

    Burlington, North Carolina, 27215

  • The University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599-5021

  • Lowcountry Center for Veterans Research

    Charleston, South Carolina, 29401

  • Novant Health Heart and Vascular Institute

    Charlotte, North Carolina, 28204

  • Trinity Medical WNY, PC

    Cheektowaga, New York, 14227

  • Cardiac Health Management Network, P.C.

    Chester, Virginia, 23836

  • Mount Sinai Hospital

    Chicago, Illinois, 60608

  • Southeast Clinical Research, LLC

    Chiefland, Florida, 32626

  • Morton Plant Mease Health Care

    Clearwater, Florida, 33756

  • VA Northeast Ohio Healthcare System

    Cleveland, Ohio, 44104-1702

  • Palmetto Health

    Columbia, South Carolina, 29203

  • Columbus Regional Research Institute

    Columbus, Georgia, 31904

  • Baylor Heart and Vascular Hospital

    Dallas, Texas, 75226

  • Soltero Cardiovascular Research Center

    Dallas, Texas, 75226

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390-8837

  • Cardiology Consultants of Danville, Inc

    Danville, Virginia, 24541

  • Accel Research Sites

    DeLand, Florida, 32720

  • Iowa Heart Center

    Des Moines, Iowa, 50314

  • Doylestown Health Cardiology

    Doylestown, Pennsylvania, 18901

  • Midwest Cardiovascular Research and Education Foundation

    Elkhart, Indiana, 46514

  • Alpine Research Organization

    Farmington, Utah, 84025

  • Integrative Research Associates

    Fort Lauderdale, Florida, 33312

  • University of North Texas Health Science Center

    Fort Worth, Texas, 76107

  • University of California San Francisco

    Fresno, California, 93701

  • University of Texas Medical Branch at Galveston

    Galveston, Texas, 77555

  • Clinical Research of Gastonia

    Gastonia, North Carolina, 28054

  • The Stern Cardiovascular Center

    Germantown, Tennessee, 38138

  • Nebraska Heart Institute

    Grand Island, Nebraska, 68803

  • East Mountain Medical Associates, PC

    Great Barrington, Massachusetts, 01230

  • Cardiology Associates of Bellin Health

    Green Bay, Wisconsin, 54301

  • Angiocardiac Care of Texas

    Houston, Texas, 77025

  • The Methodist Hospital

    Houston, Texas, 77030

  • Biopharma Informatic, Inc. Research Center

    Houston, Texas, 77084

  • Heart Center Research, LLC

    Huntsville, Alabama, 35801

  • St. Francis Medical Group-Indiana Heart Physicians, Inc

    Indianapolis, Indiana, 46237

  • Nature Coast Clinical Research

    Inverness, Florida, 34452

  • Jackson Heart Clinic, P.A.

    Jackson, Mississippi, 39216

  • Apex Cardiology/ Research Associates of Jackson

    Jackson, Tennessee, 38301

  • East Coast Institute for Research, LLC

    Jacksonville, Florida, 32216

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216

  • Lycoming Internal Medicine, Inc

    Jersey Shore, Pennsylvania, 17740

  • Richard M Kastelic and Associates

    Johnstown, Pennsylvania, 15905

  • Saint Luke's Hospital of Kansas City

    Kansas City, Missouri, 64111

  • Private Practice Leadership, LLC

    Katy, Texas, 77493

  • La Mesa Cardiac Center

    La Mesa, California, 91942

  • Purushotham, Akther & Roshan Kotha, MD Inc.

    La Mesa, California, 91942

  • Healthcare Partners LLC

    Las Vegas, Nevada, 89109

  • Palm Research Center

    Las Vegas, Nevada, 89128

  • Cardiovascular Group PC

    Lawrenceville, Georgia, 30046

  • Clinical Trials of America, Inc

    Lenoir, North Carolina, 28645

  • Maine Research Associates

    Lewiston, Maine, 04240

  • South Denver Cardiology Associates, PC

    Littleton, Colorado, 80120

  • Long Beach Center for Clinical Research

    Long Beach, California, 90807

  • VA Greater Los Angeles Healthcare System

    Los Angeles, California, 90073

  • Norton Heart Specialists

    Louisville, Kentucky, 40202

  • Meriter Wisconsin Heart

    Madison, Wisconsin, 53713

  • Garden State Heart Care, PC

    Manalapan, New Jersey, 07726

  • Carient Heart and Vascular

    Manassas, Virginia, 20109

  • North Shore University Hospital

    Manhasset, New York, 11030

  • Rama Research LLC

    Marion, Ohio, 43302

  • Marshfield Clinic

    Marshfield, Wisconsin, 54449

  • Methodist University Hospital

    Memphis, Tennessee, 38104

  • Merced Vein and Vascular Center

    Merced, California, 95340

  • Elite Clinical Research

    Miami, Florida, 33144

  • Cardiovascular Research Center of South Florida

    Miami, Florida, 33173

  • Clinical Trials of America, LLC

    Monroe, Louisiana, 71201

  • Advocate Health and Hospitals Corporation

    Naperville, Illinois, 60540

  • Long Island Cardiovascular Consultants

    New Hyde Park, New York, 11042

  • LSU Health Sciences Center

    New Orleans, Louisiana, 70112

  • Mount Sinai - PRIME

    New York, New York, 10025

  • Harlem Cardiology

    New York, New York, 10035

  • Captain James A. Lovell Federal Health Care Center

    North Chicago, Illinois, 60064

  • Valley Clinical Trials, Inc.

    Northridge, California, 91325

  • South Oklahoma Heart Research Group

    Oklahoma City, Oklahoma, 73135

  • University of California Irvine

    Orange, California, 92865

  • Orlando Health Inc.

    Orlando, Florida, 32806

  • Peninsula Research, Inc.

    Ormond Beach, Florida, 32174

  • Research Integrity, LLC

    Owensboro, Kentucky, 42303

  • MD Medical Research

    Oxon Hill, Maryland, 20745

  • CHI Health Midlands

    Papillion, Nebraska, 68046

  • McLaren Northern Michigan Hospital

    Petoskey, Michigan, 49770

  • Baylor Scott and White Health

    Plano, Texas, 75024

  • Reid Hospital

    Richmond, Indiana, 47374

  • Hunter Holmes McGuire VA Medical Center

    Richmond, Virginia, 23249

  • Medical College of Virginia Hospitals

    Richmond, Virginia, 23298

  • Covigilant Research, LLC

    Riverside, California, 92506

  • Roanoke Heart Institute PLC

    Roanoke, Virginia, 24014

  • Clinical Research of Rock Hill

    Rock Hill, South Carolina, 29732

  • Rockford Cardiovascular Associates

    Rockford, Illinois, 61107

  • Laurelton Heart Specialist, PC

    Rosedale, New York, 11422

  • Clearwater Cardiovascular Consultants

    Safety Harbor, Florida, 34695

  • Regions Hospital

    Saint Paul, Minnesota, 55101

  • Salem VA Medical Center

    Salem, Virginia, 24153

  • University of California San Francisco

    San Francisco, California, 94143

  • Sarasota Memorial Hospital

    Sarasota, Florida, 34239

  • Saratoga Clinical Research, LLC

    Saratoga Springs, New York, 12866

  • Meridian Clinical Research, LLC

    Savannah, Georgia, 31406

  • Virginia Mason Medical Center

    Seattle, Washington, 98101

  • Sanford Research

    Sioux Falls, South Dakota, 57104

  • Beacon Medical Group Clinical Research

    South Bend, Indiana, 46601

  • Northwell Health

    Southampton, New York, 11968

  • Palmetto Research Center, LLC

    Spartanburg, South Carolina, 29302

  • Saint Louis University

    St Louis, Missouri, 63110

  • St. Louis Center for Clinical Research

    St Louis, Missouri, 63128

  • St. Louis Heart and Vascular, P.C.

    St Louis, Missouri, 63136

  • Stony Brook University Medical Center

    Stony Brook, New York, 11794

  • University of South Florida

    Tampa, Florida, 33606

  • Advent Health Medical Group

    Tampa, Florida, 33613

  • CHEAR Center LLC

    The Bronx, New York, 10455

  • Cardiac Care and Vascular Medicine, PLLC

    The Bronx, New York, 10469

  • University of California

    Torrance, California, 90502

  • Atlanta Heart Specialists, LLC

    Tucker, Georgia, 30084

  • Orange County Research Center

    Tustin, California, 92780

  • Blue Coast Cardiology

    Vista, California, 92083

  • Aspirus Research Institute

    Wausau, Wisconsin, 54401

  • York Hospital, WellSpan Health

    York, Pennsylvania, 17403

Other trials in United States

Japan65 sites

  • Kasugai Municipal Hospital

    Aichi, Kasugai, 486-8510

  • Japanese Red Cross Nagoya Daini Hospital

    Aichi, Nagoya, 466-8650

  • Chiba Heart Clinic

    Chiba, Chiba, 263-0043

  • Kimitsu Chuo Hospital

    Chiba, Kisarazu, 292-8535

  • Seikeikai New Tokyo Heart Clinic

    Chiba, Matsudo, 271-0077

  • Ehime Prefectural Central Hospital

    Ehime, Matsuyama, 790-0024

  • Matsuyama Shimin Hospital

    Ehime, Matsuyama, 790-0067

  • Uwajima City Hospital

    Ehime, Uwajima, 798-8510

  • Fukuiken Saiseikai Hospital

    Fukui, Fukui, 918-8503

  • Fukuoka University Chikushi Hospital

    Fukuoka, Chikushino, 818-8502

  • Fukuokaken Saiseikai Futsukaichi Hospital

    Fukuoka, Chikushino, 818-8516

  • Saiseikai Fukuoka General Hospital

    Fukuoka, Fukuoka, 810-0001

  • National Hospital Organization Kyushu Medical Center

    Fukuoka, Fukuoka, 810-8563

  • Kyushu University Hospital

    Fukuoka, Fukuoka, 812-8582

  • Steel Memorial Yawata Hospital

    Fukuoka, Kitakyushu, 805-8508

  • Japan Community Health Care Organization Kyushu Hospital

    Fukuoka, Kitakyushu, 806-8501

  • Shirakawa Kosei General Hospital

    Fukushima, Shirakawa, 961-0005

  • Ogaki Municipal Hospital

    Gifu, Ogaki, 503-8502

  • Chuno Kosei Hospital

    Gifu, Seki, 501-3802

  • Fukuyama City Hospital

    Hiroshima, Fukuyama, 721-8511

  • Shobara Red Cross Hospital

    Hiroshima, Shobara, 727-0013

  • Matsuda Cardiovascular Clinic

    Hokkaido, Sapporo, 003-0026

  • Teine Keijinkai Clinic

    Hokkaido, Sapporo, 006-0811

  • Tomakomai City Hospital

    Hokkaido, Tomakomai, 053-8567

  • Otaru Kyokai Hospital

    Hokkaido,Otaru, 047-8510

  • Hyogo Prefectural Amagasaki General Medical Center

    Hyogo, Amagasaki, 660-8550

  • Hyogo Brain and Heart Center

    Hyogo, Himeji, 670-0981

  • National Hospital Organization Kobe Medical Center

    Hyogo, Kobe, 654-0155

  • Mito Medical Center

    Ibaraki, Higashiibaraki-gun, 311-3193

  • Tokushukai Koga General Hospital

    Ibaraki, Koga, 306-0041

  • National Hospital Organization Kanazawa Medical Center

    Ishikawa, Kanazawa, 920-8650

  • Mitoyo General Hospital

    Kagawa, Kanonji, 769-1695

  • Kagawa Prefectural Central Hospital

    Kagawa, Takamatsu, 760-8557

  • Sekishinkai Second Kawasaki Saiwai Clinic

    Kanagawa, Kawasaki, 212-0021

  • Yamamoto Clinic

    Kanagawa, Sagamihara, 252-0311

  • Kanagawa Cardiovascular and Respiratory Center

    Kanagawa, Yokohama, 236-0051

  • Japanese Red Cross Kumamoto Hospital

    Kumamoto, Kumamoto, 861-8520

  • Seiwakai Suizenji Touya Hospital

    Kumamoto, Kumamoto, 862-0950

  • Kumamoto Rosai Hospital

    Kumamoto, Yatsushiro, 866-8533

  • Omi Medical Center

    Kusatsu, 525-8585

  • Uji-Tokushukai Medical Center

    Kyoto, Uji, 611-0041

  • Sendai Kousei Hospital

    Miyagi, Sendai, 980-0873

  • Sendai Tokushukai Hospital

    Miyagi, Sendai, 981-3131

  • National Hospital Organization Sendai Medical Center

    Miyagi, Sendai, 983-8520

  • Miyazaki Medical Association Hospital

    Miyazaki, Miyazaki, 880-2102

  • Hokushin General Hospital

    Nagano, Nakano, 383-8505

  • Nagasaki Medical Center

    Nagasaki, Omura, 856-8562

  • Oita Medical Center

    Oita, Oita, 870-0263

  • Okayama City General Medical Center

    Okayama, Okayama, 700-8557

  • Naha City Hospital

    Okinawa, Naha, 902-8511

  • Nanbu Tokushukai Hospital

    Okinawa, Shimajiri-gun, 901-0493

  • Urasoe General Hospital

    Okinawa, Urasoe, 901-2132

  • Higashiosaka City Medical Center

    Osaka, Higashiosaka, 578-8588

  • Kitano Hospital

    Osaka, Osaka, 530-8480

  • Yodogawa Christian Hospital

    Osaka, Osaka, 533-0024

  • Hokusetsu General Hospital

    Osaka, Takatsuki, 569-8585

  • San-Ai Hospital

    Saitama, Saitama, 338-0837

  • Kosekai Iwatsuki-minami Hospital

    Saitama, Saitama, 339-0033

  • Tokushima Prefectural Central Hospital

    Tokushima, Tokushima, 770-8539

  • National Hospital Organization Tokyo Medical Center

    Tokyo, Meguro-ku, 152-8902

  • Ome Municipal General Hospital

    Tokyo, Ome, 198-0042

  • Tokyo Rosai Hospital

    Tokyo, Ota-ku, 143-0013

  • Sekino Hospital

    Tokyo, Toshima-ku, 171-0014

  • Minami Wakayama Medical Center

    Wakayama, Tanabe, 646-8558

  • Kanmon Medical Center

    Yamaguchi, Shimonoseki, 752-8510

Other trials in Japan

Argentina39 sites

  • Hospital Interzonal General de Agudos Dr Jose Penna

    Bahía Blanca, B8001DDU

  • Hospital Italiano Regional del Sur, Bahia Blanca

    Bahía Blanca, B8001HXM

  • CIPREC

    CABA, C1119ACN

  • Hospital Italiano de Buenos Aires

    CABA, C1199ABB

  • Instituto Cardiovascular de Buenos Aires

    Ciudad Autonoma Buenos Aires, C1428ART

  • Glenny Corp. S.A. Bioclinica Argentina

    Ciudad Autonoma Buenos Aires, C1430CKE

  • Centro Médico Viamonte

    Ciudad Autonoma de Bs As, C1120AAC

  • Sanatorio Güemes

    Ciudad Autónoma de Bs As, C1180AAX

  • Consultorios Asociados de Endocrinología e Invest Clínica

    Ciudad Autonoma de BuenosAires, C1425AGC

  • Instituto Medico Elsa Perez SRL (IMEP)

    Ciudadela, 1702

  • Sanatorio Mayo Privado SA

    Córdoba, 5000

  • Centro de Investigaciones Clinicas Instituto del Corazon

    Córdoba, X5000EVQ

  • Sanatorio Allende S.A.

    Córdoba, X5000JHQ

  • Clinica Privada Colombo- Fundacion Clinica Colombo

    Córdoba, X5002AOQ

  • Instituto Médico DAMIC S.R.L.

    Córdoba, X5003DCE

  • Hospital Privado

    Córdoba, X5016KEH

  • Clinica Coronel Suarez SA

    Coronel Suárez, B7540GHD

  • Instituto de Cardiología de Corrientes

    Corrientes, W3400AMZ

  • Hospital Italiano de La Plata

    La Plata, B1900AXI

  • Centro de Investigaciones Médicas

    Mar del Plata, B7600FYK

  • Hospital Privado de Comunidad

    Mar del Plata, B7602CBM

  • CER Instituto Médico

    Quilmes, B1878DVB

  • Instituto de Investigaciones Clínicas de Quilmes

    Quilmes, B1878GEG

  • Instituto de Investigaciones Clinicas de Rosario

    Rosario, 2000

  • Instituto Medico Fundación Grupo Colaborativo Rosario

    Rosario, 2000

  • Sanatorio Británico

    Rosario, 2000

  • Sanatorio Plaza

    Rosario, 2000

  • Instituto CAICI

    Rosario, S2000PBJ

  • CORDIS S.A., Salta

    Salta, A4400ANW

  • Centro Cardiovascular Salta

    Salta, A4406BFP

  • Corporacion Medica de Gral. San Martin S.A.

    San Martin, B1650CSQ

  • Investigaciones Clinicas Tucuman

    San Miguel de Tucumán, T4000ICL

  • Instituto de Cardiología

    San Miguel de Tucumán, T4000JCU

  • Clinica Mayo

    San Miguel de Tucumán, T4000

  • Centro Medico Luquez

    San Vicente, X5006CBI

  • Hospital "Dr. José Maria Cullen"

    Santa Fe, S3000EOZ

  • Centro de Investigaciones Clínicas del Litoral

    Santa Fe, S3000FWO

  • Clínica Olivos

    Vicente López, 1602

  • CEMEDIC - Centro de Especialidades Medicas

    Villa Luro, C1440CFD

Other trials in Argentina

Brazil37 sites

  • FGM - Clínica Paulista de Doenças Cardiovasculares

    Bela Vista, 01323-000

  • Hospital Felicio Rocho

    Belo Horizonte, 30110-060

  • Hospital Vera Cruz

    Belo Horizonte, 30140-092

  • L2IP -Instituto de Pesquisas Clínicas Ltda.

    Brasília, 70200-730

  • ICDF - Instituto de Cardiologia do Distrito Federal

    Brasília, 70673-900

  • CECAP - Centro de Cardiologia Clínica

    Brasília, 70710-100

  • Irmandade da Santa Casa de Misericordia de Curitiba

    Campina Grande do Sul, 83430-000

  • Centro Especializado em Cardiol Loema Instituto de Pesq Clin

    Campinas, 13010-001

  • IPECC - Instituto de Pesquisa Clínica de Campinas

    Campinas, 13060-080

  • CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas

    Campinas, 13087-567

  • Hospital Universitário

    Canoas, 92425-900

  • IPCEM - Instituto de Pesquisa Clínica para Estudos Multicêntricos - Universidade de Caxias do Sul

    Caxias do Sul, 95070-560

  • Irmandade da Santa Casa de Misericórdia de Curitiba

    Curitiba, 80230-130

  • Via Medica

    Goiânia, 74223-130

  • HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás

    Goiânia, 74605-020

  • ICM - Instituto do Coracao de Marilia

    Marília, 17515-000

  • Hospital São Vicente de Paulo

    Passo Fundo, 99010-080

  • Santa Casa de Misericórdia de Porto Alegre

    Porto Alegre, 90035-074

  • Centro de Pesquisas em Diabetes

    Porto Alegre, 90035-170

  • Hospital de Clínicas de Porto Alegre

    Porto Alegre, 90035-903

  • Instituto de Cardiologia Rio Grande do Sul

    Porto Alegre, 90620-001

  • Hospital Agamenon Magalhaes

    Recife, 52051-380

  • H.C.da Fac. de Medicina de Ribeirao Preto

    Ribeirão Preto, 14048-900

  • Hospital Universitário Pedro Ernesto UERJ

    Rio de Janeiro, 20551-030

  • CCBR - Rio de Janeiro - BR

    Rio de Janeiro, 22271-100

  • Cardresearch Cardiologia Assistencial e de Pesquisas Ltda

    Santa Efigênia, 30150-240

  • Pesquisare

    Santo André, 09080-110

  • Praxis Pesquisa Médica

    Santo André, 09090-790

  • CEMEC - Centro Multidisciplinar de Estudos Clínicos

    São Bernardo do Campo, 09780-000

  • Hospital de Base - Fac Med de Sao Jose do Rio Preto

    São José do Rio Preto, 15090-000

  • Centro de Pesquisa Clinica - CPCLIN

    São Paulo, 01228-200

  • CDEC BRASIL - Centro de Desenvolvimento em Estudos Clínicos Brasil

    São Paulo, 04020-060

  • CEPIC - Centro Paulista de Investigacao Clinica

    São Paulo, 04266-010

  • Dr. Consulta

    São Paulo, 05016-090

  • INCOR e Hospital das Clínicas da Universidade de São Paulo

    São Paulo, 05403-000

  • CEDOES - Diagnóstico e Pesquisa,Vitória

    Vitória, 29055-450

  • Santa Casa de Votuporanga

    Votuporanga, 15500-003

Other trials in Brazil

Germany35 sites

  • Universitätsklinikum Aachen, AöR

    Aachen, 52074

  • Praxis Dr. Rieker, Berlin

    Berlin, 10789

  • Vivantes Netzwerk für Gesundheit GmbH

    Berlin, 10967

  • Charité - Universitätsmedizin Berlin

    Berlin, 12203

  • Vivantes Netzwerk für Gesundheit GmbH

    Berlin, 12351

  • Charité - Universitätsmedizin Berlin

    Berlin, 13353

  • Klinikum Bielefeld gGmbH

    Bielefeld, 33604

  • Augusta-Kranken-Anstalt gGmbH

    Bochum, 44791

  • Praxis Dr. Menzel

    Dessau, 06846

  • St. Johannes Hospital Dortmund

    Dortmund, 44137

  • Städtisches Klinikum Dresden

    Dresden, 01067

  • Universitätsklinikum Carl Gustav Carus Dresden

    Dresden, 01307

  • Helios Klinikum Erfurt

    Erfurt, 99089

  • Studienzentrum Bocholderstraße

    Essen, 45355

  • ClinPhenomics GmbH & Co KG, Frankfurt

    Frankfurt, 60596

  • Universitätsmedizin Göttingen, Georg-August-Universität

    Göttingen, 37075

  • Medizinische Hochschule Hannover

    Hanover, 30625

  • Universitätsklinikum Heidelberg

    Heidelberg, 69120

  • Universitätsklinikum des Saarlandes

    Homburg, 66421

  • Universitätsklinikum Jena

    Jena, 07740

  • Universitätsklinikum Schleswig-Holstein, Campus Kiel

    Kiel, 24105

  • Asklepios Klinik Langen-Seligenstadt GmbH

    Langen, 63225

  • Märkische Gesundheitsholding GmbH & Co. KG, Klinikum Lüdenscheid

    Lüdenscheid, 58515

  • Praxis Dr. Sarnighausen, Lüneburg

    Lüneburg, 21339

  • Katholisches Klinikum Mainz

    Mainz, 55131

  • Gemeinschaftspraxis Drs. Kohler/Salbach, Mannheim

    Mannheim, 68165

  • Deutsches Herzzentrum München

    München, 80636

  • Gemeinschaftspraxis Dres Haggenmiller/Jeserich

    Nuremberg, 90402

  • Kardiologische Praxis Papenburg

    Papenburg, 26871

  • Universitätsklinikum Regensburg

    Regensburg, 93053

  • Praxis Dr. Stenzel, Riesa

    Riesa, 01587

  • Zentrum für Klinische Forschung

    Wangen, 88239

  • Josephs-Hospital Warendorf

    Warendorf, 48231

  • Kardiologische Praxis, Wermsdorf

    Wermsdorf, 04779

  • Petrus-Krankenhaus

    Wuppertal, 42283

Other trials in Germany

Poland35 sites

  • Univ. Clinic Hosp, Bialystok

    Bialystok, 15-276

  • KLIMED Marek Klimkiewicz

    Bialystok, 15-765

  • ClinicMed Badurski i wspolnicy Spolka Jawna, Bialystok

    Bialystok, 15-879

  • American Heart of Poland Sp. z o.o.

    Bielsko-Biala, 43-316

  • NZOZ Centrum Medyczne KERmed

    Bydgoszcz, 85231

  • Polsko-Amerykanskie Kliniki Serca

    Chorzów, 32-500

  • American Heart of Poland Sp. z o.o.

    Dąbrowa Górnicza, 41-300

  • Poradnia Kardiologiczna Jaroslaw Jurowiecki

    Gdansk, 80-286

  • University Clinical Center, Gdansk

    Gdansk, 80-952

  • Indywidualna Specjalistyczna Praktyka Lekarska

    Gdynia, 81-157

  • NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog.

    Gdynia, 81-423

  • Szpital Zakonu Bonifratow Sp. z o.o.

    Katowice, 40-211

  • Specialistic Cardiology&Hypertension Out-patient Clin,Kielce

    Kielce, 25525

  • Leszek Bryniarski Specialized Medical Cabinet

    Krakow, 30-082

  • Krakow Specialistic Hospital of John Paul II

    Krakow, 31-202

  • ETG Lodz

    Lodz, 90-302

  • Nzoz Salus

    Lodz, 91-002

  • Individual Specialized Practice

    Lodz, 94-255

  • Lowickie Cardiology Center

    Lowicz, 99-400

  • American Heart of Poland Sp. z o.o.

    Nysa, 48-300

  • Medicome Sp. z o.o.

    Oświęcim, 32-600

  • NZOZ HEUREKA, Piaseczno

    Piaseczno, 05-500

  • Specialized Practice Dr. Janusz Spyra

    Ruda Śląska, 41-709

  • Centrum Medyczne Medyk

    Rzeszów, 35-055

  • Lukmed Lukasz Wozniak

    Siedlce, 08-110

  • ETG Skierniewice

    Skierniewice, 96-100

  • KO-MED Centra Kliniczne Staszow

    Staszów, 28-200

  • The Provincial Polyclinical Hospital in Torun

    Torun, 87-100

  • American Heart of Poland Sp. z o.o.

    Tychy, 43-100

  • American Heart of Poland Sp. z o.o.

    Ustroń, 43-450

  • Samodzielny Publiczny Centralny Szpital Kliniczny

    Warsaw, 02-097

  • ETG Warszawa

    Warsaw, 02-793

  • 4. Military Clinical Hospital with Polyclinic SP ZOZ

    Wroclaw, 50-981

  • Zgierskie Center of Cardiology MED-PRO

    Zgierz, 95-100

  • Specialist Hospital J. Dietla NZOZ Specialized Clinic "Gemini"

    Żychlin, 62-571

Other trials in Poland

Canada34 sites

  • Brampton Cardio Pulmonary Clinic

    Brampton, Ontario, L6W 2X7

  • Brampton Research Associates

    Brampton, Ontario, L6Z 4N5

  • ViaCar Recherche Clinique Inc

    Brossard, Quebec, J4Z 2K9

  • JBN Medical Diagnostic Services Inc.

    Burlington, Ontario, L7M 4Y1

  • Cambridge Cardiac Care Inc.

    Cambridge, Ontario, N1R 6V6

  • Dr. Saul Vizel

    Cambridge, Ontario, N1R 7R1

  • Royal Alexandra Hospital

    Edmonton, Alberta, T5H 3V9

  • Cardiovascular Contract Research Organization LTD

    Greater Sudbury, Ontario, P3E 3Y9

  • ViaCar Recherche Clinique Inc

    Greenfield Park, Quebec, J4V 2G8

  • QEII Health Sciences Centre

    Halifax, Nova Scotia, B3H 3A7

  • Curnew Medicine Professional Corporation

    Hamilton, Ontario, L8L 0A9

  • Hamilton General Hospital

    Hamilton, Ontario, L8L 2X2

  • University Hospital (LHSC)

    London, Ontario, N6A 5A5

  • Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud

    Longeuil, Quebec, J4M 2X1

  • G.A. Research Associates Ltd

    Moncton, New Brunswick, E1G 1A7

  • Montreal Heart Institute

    Montreal, Quebec, H1T 1C8

  • Clinique Santé Cardio MC

    Montreal, Quebec, H1T 3Y7

  • Montreal General Hospital - McGill University Health Centre

    Montreal, Quebec, H3G 1A4

  • McGill University Health Centre (MUHC)

    Montreal, Quebec, H4A 3J1

  • PACE (Partners in Advanced Cardiac Evaluation)

    Newmarket, Ontario, L3Y 2P6

  • Medical Arts Health Research Group

    North Vancouver, British Columbia, V7M 2H4

  • M Heffernan Medicine Professional Corp.

    Oakville, Ontario, L6K 3W7

  • Kawartha Cardiology Clinical Trials

    Peterborough, Ontario, K9J 0B2

  • IUCPQ (Laval University)

    Québec, G1V 4G5

  • Royal University Hospital

    Saskatoon, Saskatchewan, S7N 0W8

  • Heart Health Institute

    Scarborough Village, Ontario, M1B 4Z8

  • Scarborough Cardiology Research

    Scarborough Village, Ontario, M1E 5E9

  • Canadian Phase Onward Inc.

    Toronto, Ontario, M3J 0K2

  • North York Diagnostic and Cardiac Centre

    Toronto, Ontario, M6B 1N6

  • Vancouver General Hospital

    Vancouver, British Columbia, V5Z 1M9

  • Victoria Heart Institute Foundation

    Victoria, British Columbia, V8R 1B2

  • Mohan Babapulle Medicine Professional Medicine

    Waterloo, Ontario, N2T 0C1

  • St. Boniface General Hospital

    Winnipeg, Manitoba, R2H 2A6

  • Dr. Louis C.H. Yao

    York, Ontario, M9N 1W4

Other trials in Canada

Czechia30 sites

  • Poliklinika Humanitas

    Bílovec, 74301

  • Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno

    Brno, 603 00

  • MUDr. Alexandra Ludkova

    Brno, 615 00

  • University Hospital Brno

    Brno, 625 00

  • Vojenska nemocnice Brno

    Brno, 63600

  • Nemocnice Milosrdnych bratri

    Brno, 63900

  • Fakultni nemocnice u sv. Anny v Brne

    Brno, 656 91

  • Univ.Hosp U Svate Anny, I.Internal Clinic-Cardiology,Brno

    Brno, 65691

  • Edumed s.r.o

    Broumov, 55001

  • MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance

    Chrudim, 53702

  • Hospital Frydek Mistek

    Frýdek-Místek, 73818

  • Nemocnice Havlickuv Brod p.o.

    Havlíčkův Brod, 580 22

  • Gepamed s.r.o., Pulm. Outpat. Office, Hradec Kralove

    Hradec Králové, 50002

  • KardioLouny s.r.o.

    Louny, 440 01

  • InterKardioML s.r.o.

    Mariánské Lázně, 353 01

  • Zdenek Vomacka

    Olomouc, 779 00

  • PV-Kardiologie s.r.o.

    Pardubice, 53002

  • Vseobecna fakultni nemocnice V Praze

    Prague, 128 00

  • Institute for Clinical and Experimental Medicine

    Prague, 140 21

  • University Hospital Motol

    Prague, 15006

  • Corintez s.r.o.

    Prague, 158 00

  • University Thomayer's Hospital

    Praha 4 - Krc, 140 59

  • Kardio Vaclavik s.r.o.

    Přerov, 75000

  • Nemocnice Trebic p.o.

    Třebíč, 674 01

  • Kardiologicka ambulance

    Třemošná, 33011

  • Kardiologicka ambulance MUDr. Ferkl s.r.o.

    Trutnov, 541 01

  • Clinical Trials Services s.r.o

    Uherské Hradiště, 68601

  • Cardiology Private Practice

    Uničov, 783 91

  • Angiocor s.r.o

    Zlín, 76001

  • KIGE s.r.o

    Znojmo, 66902

Other trials in Czechia

China27 sites

  • Cardiovascular Institute and Fu Wai Hospital

    Beijing, 100037

  • Beijing Friendship Hospital

    Beijing, 100050

  • First Hospital of Jilin University

    Changchun, 130021

  • Hunan Provincial People's Hospital

    Changsha, 410005

  • 2nd Xiangya Hospital of Central South University

    Changsha, 410011

  • The Third Hospital of Changsha

    Changsha, 410015

  • Dongguan People's Hospital

    Dongguan, 523059

  • The First Affiliated Hospital of Fujian Medical University

    Fuzhou, 350005

  • The First Afiliated Hospital, Sun Yet-sen University

    Guangzhou, 510080

  • Guangzhou First Municipal People's Hospital

    Guangzhou, 510180

  • Haikou People's Hospital

    Haikou, 570208

  • HaiNan Provincial People's Hospital

    Haikou, 570311

  • The First Affiliated Hospital of Lanzhou University

    Lanzhou, 730000

  • The Second Affiliated Hospital of Lanzhou Medical University

    Lanzhou, 730030

  • The Affiliated Hospital of Southwest Medical University

    Luzhou, 646099

  • Nanchang University Affiliated 3rd Hospital

    Nanchang, 330008

  • First Hospital Affiliated with Nanjing Medical University

    Nanjing, 210029

  • Huashan Hospital, Fudan University

    Shanghai, 200040

  • General Hospital of Shenyang Military Region

    Shenyang, 110016

  • Shengjing Hospital of China Medical University

    Shenyang, 110072

  • Tianjin Union Medical Center Nankai University Affiliated Hospital

    Tianjin, 300121

  • Tongji Hospital, Tongji University

    Wuhan, 430030

  • Renmin Hospital of Wuhan University

    Wuhan, 430060

  • First Affiliated Hospital of Xi'an JiaoTong University

    Xi'an, 710061

  • Yanbian University Hospital

    Yanji, 133000

  • the first people hospital of Yue Yang

    Yueyang, 414000

  • Affiliated Hospital of Jiangsu University

    Zhenjiang, 212013

Other trials in China

Hungary20 sites

  • Lausmed Kft. Outpatient Unit of Internal Medicine

    Baja, 6500

  • Belgyogyaszati es Kardiologiai Maganrendelo

    Békéscsaba, 5600

  • Budai Irgalmasrendi Korhaz

    Budapest, 1023

  • Clinexpert Kft.

    Budapest, 1033

  • Bajcsy-Zsilinszky Hospital and Clinic

    Budapest, 1106

  • Semmelweis University

    Budapest, 1122

  • Milit.Hosp.-State Health Cent.

    Budapest, 1134

  • Uzsoki Street Hospital, Budapest

    Budapest, 1145

  • Nehezlegzes Ambulancia

    Debrecen, 4027

  • University Debrecen Hospital

    Debrecen, 4032

  • Bugat Pal Hospital, Gyongyos

    Gyöngyös, 3200

  • Studium Egeszseghaz Kft.

    Kalocsa, 6300

  • Selye Janos Hospital Komarom

    Komárom, 2921

  • Dorottya Kanizsai Hospital

    Nagykanizsa, 8800

  • Medifarma-98 Kft.

    Nyíregyháza, 4400

  • Dr. Nagy Laszlo Kardiologiai Maganrendeles

    Orosháza, 5900

  • University of Pecs

    Pécs, 7624

  • Da Vinci Private Clinic

    Pécs, 7635

  • Fejer County Saint George University Teaching Hospital

    Székesfehérvár, 8000

  • Veszpremi Sziv es Egeszseg Centrum

    Veszprém, 8200

Other trials in Hungary

Netherlands20 sites

  • Ziekenhuisgroep Twente locatie Almelo

    Almelo, 7609 PP

  • BovenIJ Ziekenhuis

    Amsterdam, 1034 CS

  • Onze Lieve Vrouwe Gasthuis, Locatie West

    Amsterdam, 1061 AE

  • Amsterdam UMC Locatie VUMC

    Amsterdam, 1081HV

  • Onze Lieve Vrouwe Gasthuis

    Amsterdam, 1091AC

  • Amsterdam UMC, Locatie AMC

    Amsterdam, 1105 AZ

  • Rode Kruis Ziekenhuis Beverwijk

    Beverwijk, 1942 LE

  • Tergooiziekenhuizen locatie Blaricum

    Blaricum, 1261 AN

  • Amphia Ziekenhuis

    Breda, 4818 CK

  • Ziekenhuis Gelderse Vallei

    Ede, 6716 RP

  • Catharina Ziekenhuis

    Eindhoven, 5623 EJ

  • Universitair Medisch Centrum Groningen

    Groningen, 9713 GZ

  • Zuyderland Medisch Centrum

    Heerlen, 6419 PC

  • Maastricht University

    Maastricht, 6229 HX

  • Diaconessenhuis Meppel

    Meppel, 7943 KA

  • St. Antonius ziekenhuis, locatie Nieuwegein

    Nieuwegein, 3435 CM

  • Radboud Universitair Medisch Centrum

    Nijmegen, 6525 GL

  • Franciscus Gasthuis

    Rotterdam, 3045 PM

  • De Heel - Zaans Medisch Centrum

    Zaandam, 1502 DV

  • Gelre Ziekenhuis Zutphen

    Zutphen, 7207 AE

Other trials in Netherlands

India15 sites

  • Doctor Jivraj Mehta Smarak Health Foundation

    Ahmedabad, 380007

  • Narayana Institute of Cardiac Sciences

    Bangalore, 560099

  • Rajarajeswari Medical College

    Bengaluru, 560074

  • Madras Medical Mission,

    Chennai, 600 037

  • Apollo Speciality Hospital

    Chennai, 600006

  • Kamalnayan Bajaj Hospital

    Chhatrapati Sambhajinagar, 431 005

  • Medanta-The Medicity

    Gūrgaon, 122001

  • GNRC Hospital

    Guwahati, 781006

  • B.M. Birla Heart research Centre

    Kolkata, 700027

  • Vijan Cardiac and Critical Care Centre

    Nashik, 422005

  • Siddhi Hospital

    Nashik, 422007

  • GB Pant Hospital

    New Delhi, 110002

  • Fortis Escorts Heart Institute

    New Delhi, 110025

  • Sir Gangaram Hospital

    New Delhi, 110060

  • Batra Hospital and Medical Research Centre

    New Delhi, 110062

Other trials in India

Mexico14 sites

  • Hospital Cardiologica Aguascalientes

    Aguascalientes, 20230

  • Centro de Investigacion Biomedica y Farmaceutica, S.C.

    Distrito Federal, 03100

  • Hospital Ramon Garibay

    Guadalajara, 44100

  • Diseño y Planeación en Investigación Médica SC

    Guadalajara, 44130

  • Unidad de Investigacion Clinica Cardiometabolica de Occident

    Guadalajara, 44150

  • Cardiologia Clinica e Intervencionista

    Guadalajara, 44670

  • Centro de Investigación Clinica Acelerada, S.C.

    México, 07020

  • CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc

    México, C.P. 11650

  • Instituto Cardiovascular de Monclova, S de RL de CV

    Monclova, 25750

  • Hospital Universitario Dr Jose Eleuterio Gonzalez

    Nuevo León, 64460

  • Centro Integral Medico SJR S.C.

    San Juan del Río, 76800

  • Cardioarritmias e Investigación S.C

    San Luis Potosí City, 78213

  • Centro de Investigacion Cardiovascular y Metabolica

    Tijuana, 22500

  • Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V.

    Torreón, 27000

Other trials in Mexico

Romania14 sites

  • Spitalul Clinic De Urgenta "Prof. Dr. Agrippa Ionescu"

    Baloteşti, 077015

  • C.M.D.T.A. NEOMED, Brasov

    Brasov, 500283

  • CMDTA Washington, Bucharest

    Bucharest, 011794

  • Spitalul Clinic Colentina

    Bucharest, 020125

  • Emergency Clinical Hospital 'Sf. Panteliomon'

    Bucharest, 021659

  • Emergency University Hospital, Bucharest

    Bucharest, 022328

  • Prof.C.C.Iliescu Hospital, National Institute of Cardiology

    Bucharest, 022328

  • Emergency University Hospital, Bucharest

    Bucharest, 050098

  • Spitalul Clinic "Prof. Dr. Theodor Burghele"

    Bucharest, 050659

  • Clinica Medicala Data Plus SRL

    Bucharest, 10192

  • S.C Cardiomed S.R.L

    Craiova, 200505

  • Spital Judetean Deva

    Deva, 330084

  • S.C Medicali's S.R.L

    Timișoara, 300043

  • Spitalul Clinic Judetean de Urgenta, Timisoara

    Timișoara, 300723

Other trials in Romania

Australia13 sites

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000

  • Adelaide Medical Research

    Ashford, South Australia, 5035

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042

  • The Northern Hospital

    Epping, Victoria, 3076

  • Peninsula Private Hospital

    Frankston, Victoria, 3199

  • Heart and Vascular Research

    Fullarton, South Australia, 5063

  • University Hospital Geelong

    Geelong, Victoria, 3220

  • Pendlebury Research

    Kotara, New South Wales, 2289

  • CORE Research Group

    Milton, Queensland, 4064

  • John Hunter Hospital

    New Lambton Heights, New South Wales, 2305

  • Mount Hospital

    Perth, Western Australia, 6000

  • Gold Coast University Hospital

    Southport, Queensland, 4215

  • The Queen Elizabeth Hospital

    Woodville South, South Australia, 5011

Other trials in Australia

Colombia13 sites

  • Corazon IPS S.A.S.

    Barranquilla, 080003

  • Centro de Reumatologia y Ortopedia SAS, Barranquilla

    Barranquilla, 080020

  • IPS Centro Cientifico Asistencia

    Barranquilla, 080020

  • Endocare Research Institute

    Bogotá, 111611

  • CardioColombia S.A.S.

    Bogota D.C, 111611

  • IPS Centro Medico Julián Coronel S.A.

    Cali, 760002

  • Fundación Valle del Lili

    Cali, 760032

  • Centro de Investigaciones Clinicas S.A.S

    Cali, 760036

  • Centro de Diagnostico Cardilogico

    Cartagena, 130001

  • Centro cardiovascular Aristides

    Cartagena, 130010

  • Fundación Cardiovascular de Colombia

    Floridablanca, 681002

  • Asociacion IPS Medicos Internistas de Caldas

    Manizales, 170004

  • Promotora Medica Las Americas SA

    Medellín, 050025

Other trials in Colombia

Italy13 sites

  • Azienda Ospedaliera G. Rummo

    Benevento, 82100

  • ASST Papa Giovanni XXIII - A.O. Papa Giovanni XXIII

    Bergamo, 24127

  • Azienda Ospedaliera Universitaria Arcispedale Sant'Anna

    Cona (FE), 44124

  • Ospedale della Val di Chiana Santa Margherita

    Cortona, 52040

  • Milano Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico

    Milan, 20122

  • Centro Cardiologico Monzino-IRCCS

    Milan, 20138

  • Azienda Ospedaliera Universitaria "Federico II"

    Naples, 80131

  • Azienda Ospedaliera Universitaria Pisana

    Pisa, 56126

  • AOU Policlinico Umberto I

    Roma, 00161

  • Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza

    Roma, 00189

  • Istituto Clinico Humanitas

    Rozzano (MI), 20089

  • IRCCS Gruppo Multimedica

    Sesto San Giovanni (MI), 20099

  • Azienda Servizi Sanitari 1 Triestina

    Trieste, 34128

Other trials in Italy

South Africa13 sites

  • Cardiology Clinical Research

    Alberton, 1449

  • Iatros International

    Bloemfontein, 9301

  • Universitas Hospital Cardiology Research

    Bloemfontein, 9301

  • Corbod Research

    Cape Town, 7500

  • TREAD Research

    Cape Town, 7500

  • Tiervlei Trial Centre

    Cape Town, 7530

  • Excellentis Clinical Trials

    George, 6529

  • Clinresco

    Johannesburg, 1619

  • Chris Hani Baragwanath Hospital: Cardiology Department

    Johannesburg, 1862

  • MERC Research

    Kempton Park, 1619

  • Into Research

    Pretoria, 181

  • Dr JM Engelbrecht

    Somerset West, 7130

  • Clinical Projects Research

    Worcester, 6850

Other trials in South Africa

South Korea13 sites

  • Inje University Busan Paik Hospital

    Busan, 47392

  • Dong-A University Hospital

    Busan, 49201

  • Chungbuk National University Hospital

    Cheongju-si, 28644

  • Chungnam National University Hospital

    Daejeon, 35015

  • Chonnam National University Hospital

    Gwangju, 61469

  • Seoul National University Bundang Hospital

    Gyeonggi-do, 13620

  • Gachon University Gil Medical Center

    Incheon, 21565

  • Seoul National University Hospital

    Seoul, 03080

  • Severance Hospital

    Seoul, 03722

  • Asan Medical Center

    Seoul, 05505

  • Samsung Medical Center

    Seoul, 06351

  • Korea University Guro Hospital

    Seoul, 08308

  • Wonju Severance Christian Hosp

    Wŏnju, 26426

Other trials in South Korea

Spain13 sites

  • Hospital Quiron. I.C.U.

    Barcelona, 08023

  • Hospital Santa Creu i Sant Pau

    Barcelona, 08025

  • Hospital Sanitas CIMA

    Barcelona, 08034

  • Hospital Universitario Virgen de la Arrixaca

    El Palmar, 30120

  • Hospital General Universitario Gregorio Marañón

    Madrid, 28007

  • Hospital Ramón y Cajal

    Madrid, 28034

  • Hospital La Paz

    Madrid, 28046

  • Hospital Puerta de Hierro

    Majadahonda, 28222

  • Hospital Virgen de la Victoria

    Málaga, 29010

  • Hospital Clínico de Santiago

    Santiago de Compostela, 15706

  • Hospital Virgen Macarena

    Seville, 41009

  • Hospital General Universitario de Valencia

    Valencia, 46014

  • Hospital Arnau de Vilanova

    Valencia, 46015

Other trials in Spain

Belgium9 sites

  • C.H.U. de Charleroi

    Charleroi, 6000

  • AZ Sint-Blasius

    Dendermonde, 9200

  • Ziekenhuis Oost-Limburg - Campus Sint-Jan

    Genk, 3600

  • AZ Maria Middelares

    Ghent, 9000

  • Grand Hôpital de Charleroi

    Gilly, 6060

  • Jessa Ziekenhuis - Campus Virga Jesse

    Hasselt, 3500

  • La Louvière - UNIV CHU Tivoli

    La Louvière, 7100

  • UZ Leuven

    Leuven, 3000

  • Liège - HOSP CHR de la Citadelle

    Liège, 4000

Other trials in Belgium

United Kingdom8 sites

  • Barnet General Hospital

    Barnet, EN5 3DJ

  • University Hospital of Wales

    Cardiff, CF14 4XU

  • Park & St Francis Surgery

    Eastleigh, SO53 4ST

  • Wycombe General Hospital

    High Wycombe, HP11 2TT

  • Glenfield Hospital

    Leicester, LE3 9QP

  • St Bartholomew's Hospital

    London, EC1A 7BE

  • St Mary's Hospital

    Newport, PO30 5TG

  • Morriston Hospital

    Swansea, SA6 6NL

Other trials in United Kingdom

Singapore4 sites

  • National University Hospital

    Singapore, 119074

  • National Heart Center

    Singapore, 169609

  • Tan Tock Seng Hospital

    Singapore, 308433

  • Khoo Teck Puat Hospital

    Singapore, 768828

Other trials in Singapore

About this study

Official title: A Phase III Randomised, Double-blind Trial to Evaluate Efficacy and Safety of Once Daily Empagliflozin 10 mg Compared to Placebo, in Patients With Chronic Heart Failure With Preserved Ejection Fraction (HFpEF)

This is a study in adults with chronic heart failure. People with chronic heart failure may need to be hospitalised for their condition. Some people with chronic heart failure may eventually die from their condition. The purpose of the study is to find out whether a medicine called empagliflozin lowers the chances of patients having to go to hospital for heart failure and whether it improves their survival. The study is open to patients with a type of chronic heart failure called chronic heart failure with preserved ejection fraction.

Participants stay in the study until researchers have enough information about how effective empagliflozin is. It is expected that participants who enter at the very beginning of the enrolment period may be in the study for over 3 years, while participants who enter near the end of the enrolment period may be in the study for less than 2 years. The participants are put into 2 groups. It is decided by chance who gets into which group. One group gets empagliflozin tablets every day and the other group gets placebo tablets every day. Placebo tablets look like empagliflozin tablets but contain no medicine.

Participants visit the doctors regularly. During these visits, the doctors collect information about the participant's health. The doctors want to know how many patients had to go to hospital because of heart failure or who died from cardiovascular disease.

Conditions
Heart Failure
Being tested
Empagliflozin, Placebo
Medical subject headings
Heart Failure

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • EmpagliflozinDrug

    Also called JARDIANCE, JARDIANZ, GIBTULIO

    once daily

  • PlaceboDrug

    once daily

Study groups in NCT03057951
Study groupRoleWhat they receive
10 mg EmpagliflozinExperimentalNot described
Receives: Drug: Empagliflozin
PlaceboPlacebo comparatorNot described
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time to First Event of Adjudicated Cardiovascular (CV) Death or Adjudicated Hospitalisation for Heart Failure (HHF)

    Failure with preserved Ejection Fraction (HFpEF). The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:

    Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].

    Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.

    Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.

    Measured: From randomization until completion of the planned treatment phase, up to 1403 days.

Secondary outcomes (9)

  1. Occurrence of Adjudicated Hospitalisation for Heart Failure (HHF) (First and Recurrent)

    Reported is the total number of adjudicated HHF events (first and recurrent) which occurred.

    Measured: From randomization until completion of the planned treatment phase, up to 1403 days.

  2. eGFR (CKD-EPI) cr Slope of Change From Baseline

    Glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR(CKD-EPI)cr) slope of change from baseline.

    Available on-treatment change-from-baseline data were used. The slope represents the long term effect of eGFR change from baseline and provides the yearly rate of decline.

    Timepoints after baseline were included in calculation of slope of change from baseline.

    The slope per patient was calculated using a random coefficient model with terms for treatment, region, baseline status of diabetes, age, sex, left ventricular ejection fraction (LVEF) and glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula (eGFR (CKD-EPI)cr) at baseline and in addition the factors "time", "treatment-by-time interaction", and "baseline eGFR (CKD-EPI)cr-by-time interaction".

    Measured: At baseline, week 4, 12, 32, 52, 76, 100, 124, 148, 172 and week 196, up to 1043 days.

  3. Time to the First Event in the Composite Renal Endpoint: Chronic Dialysis, Renal Transplant, or Sustained Reduction in eGFR (CKD-EPI)cr

    Chronic dialysis was defined as dialysis with a frequency of twice per week or more for at least 90 days.

    Sustained was determined by two or more consecutive post-baseline central laboratory measurement separated by at least 30 days.

    Reduction in glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR (CKD-EPI)cr) was defined as reduction in eGFR from baseline ≥40%, eGFR <15 mL/min/1.73 m^2 for patients with baseline eGFR ≥30 mL/min/1.73 m^2, or eGFR <10 mL/min/1.73 m^2 for patients with baseline eGFR <30 mL/min/1.73 m^2.

    The incidence rate per 100 patient years (100 * number of patients with event / time at risk [years]) is reported. Time at risk [year] is calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.

    Abbreviation:

    Patient-years (pt-yrs).

    Measured: From randomization until completion of the planned treatment phase, up to 1403 days.

  4. Time to First Adjudicated Hospitalisation for Heart Failure (HHF)

    Time to first adjudicated HHF. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:

    Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].

    Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.

    Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.

    Measured: From randomization until completion of the planned treatment phase, up to 1403 days.

  5. Time to Adjudicated Cardiovascular (CV) Death

    Time to adjudicated CV death. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:

    Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].

    Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.

    Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.

    Measured: From randomization until completion of the planned treatment phase, up to 1403 days.

  6. Time to All-cause Mortality

    Time to all-cause mortality. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:

    Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].

    Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.

    Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.

    Measured: From randomization until completion of the planned treatment phase, up to 1403 days.

  7. Time to Onset of Diabetes Mellitus (DM) in Patients With Pre-DM

    Time to onset of DM (defined as HbA1c ≥6.5% or as diagnosed by the investigator) in patients with pre-DM.

    Pre-DM was defined as no history of DM and no HbA1c ≥6.5% before treatment, and a pre-treatment HbA1c value of ≥5.7% and <6.5%.

    The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:

    Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].

    Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.

    Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.

    Measured: From randomization until completion of the planned treatment phase, to 1403 days.

  8. Change From Baseline in Kansas City Cardiomyopathy Questionaire (KCCQ) Clinical Summary Score at Week 52

    The KCCQ is a 23-item self-administered questionnaire designed to evaluate physical limitations, symptoms (frequency, severity, and changes over time), social limitations, self-efficacy, and quality of life in patients with Heart Failure. The KCCQ-clinical summary score comprises the following domains: Symptom frequency, symptom burden and physical limitation. The score is calculated by summing domain responses and then transforming scores to a 0-100 unit scale with higher scores indicating better health status.

    For patients who died, a worst score (score of 0) was imputed for the score at all subsequent scheduled visits after the date of death where the score would have been assessed.

    Change from baseline in KCCQ-score at week 52 was modeled using a MMRM with visit (week 12, 32 and 52) as repeated measures, adjusted mean (standard error) at week 52 is reported.

    Measured: At baseline and at week 12, week 32 and week 52.

  9. Occurrence of All-cause Hospitalisation (First and Recurrent)

    Occurrence of all-cause hospitalisation (first and recurrent). Total number of all cause hospitalisations is reported.

    Measured: From randomization until completion of the planned treatment phase, up to 1403 days.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted20 Feb 2017
  2. Study start2 Mar 2017
  3. Primary completion26 Apr 2021
  4. Study completion26 Apr 2021

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
5,988 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT03057951
Sponsor's protocol ID
1245.110
Other IDs
2016-002278-11, 2016
Status last verified
Jun 2022
First submitted
16 Feb 2017
Last updated
6 Jun 2022
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No

Publications

  • Ferreira JP, Packer M, Butler J, Vasques-Novoa F, Marques P, Pocock S, Filippatos G, Zannad F, Anker SD. Serum Magnesium, Outcomes, and the Effect of Empagliflozin in Heart Failure With Mildly Reduced and Preserved Ejection Fraction: Findings From EMPEROR-Preserved. JACC Heart Fail. 2026 Feb;14(2):102889. doi: 10.1016/j.jchf.2025.102889. Epub 2026 Jan 5.

    PubMed 41493412

  • Carson P, Teerlink JR, Komajda M, Anand I, Packer M, Butler J, Doehner W, Ferreira JP, Filippatos G, Haass M, Miller A, Pehrson S, Pocock SJ, Iwata T, Brueckmann M, Gasior T, Zannad F, Anker SD. Comparison of Investigator-Reported and Centrally Adjudicated Heart Failure Outcomes in the EMPEROR-Preserved Trial. JACC Heart Fail. 2025 May;13(5):710-721. doi: 10.1016/j.jchf.2024.10.021. Epub 2025 Jan 29.

    PubMed 39895437

  • Natale P, Tunnicliffe DJ, Toyama T, Palmer SC, Saglimbene VM, Ruospo M, Gargano L, Stallone G, Gesualdo L, Strippoli GF. Sodium-glucose co-transporter protein 2 (SGLT2) inhibitors for people with chronic kidney disease and diabetes. Cochrane Database Syst Rev. 2024 May 21;5(5):CD015588. doi: 10.1002/14651858.CD015588.pub2.

    PubMed 38770818

  • Talha KM, Green J, Filippatos G, Pocock S, Zannad F, Brueckmann M, Schueler E, Ofstad AP, Ferreira JP, Anker SD, Butler J, Rosenstock J, Packer M. Impact of empagliflozin on insulin needs in patients with heart failure and diabetes: An EMPEROR-Pooled analysis. Diabetes Obes Metab. 2024 Jul;26(7):2578-2587. doi: 10.1111/dom.15572. Epub 2024 Apr 1.

    PubMed 38558314

  • Ferreira JP, Packer M, Sattar N, Butler J, Pocock SJ, Anker SD, Maldonado SG, Panova-Noeva M, Sumin M, Masson S, Zannad F, Januzzi JL. Carbohydrate antigen 125 concentrations across the ejection fraction spectrum in chronic heart failure: The EMPEROR programme. Eur J Heart Fail. 2024 Apr;26(4):788-802. doi: 10.1002/ejhf.3166. Epub 2024 Mar 4.

    PubMed 38439582

  • Coats AJS, Butler J, Tsutsui H, Doehner W, Filippatos G, Ferreira JP, Bohm M, Chopra VK, Verma S, Nordaby M, Iwata T, Nitta D, Ponikowski P, Zannad F, Packer M, Anker SD. Efficacy of empagliflozin in heart failure with preserved ejection fraction according to frailty status in EMPEROR-Preserved. J Cachexia Sarcopenia Muscle. 2024 Feb;15(1):412-424. doi: 10.1002/jcsm.13393. Epub 2023 Dec 29.

    PubMed 38158636

  • Ferreira JP, Butler J, Anker SD, Januzzi JL, Panova-Noeva M, Reese-Petersen AL, Sattar N, Schueler E, Pocock SJ, Filippatos G, Packer M, Sumin M, Zannad F; EMPEROR Committees and Investigators. Effects of empagliflozin on collagen biomarkers in patients with heart failure: Findings from the EMPEROR trials. Eur J Heart Fail. 2024 Feb;26(2):274-284. doi: 10.1002/ejhf.3101. Epub 2023 Dec 28.

    PubMed 38037709

  • Zannad F, Macari S. Drug treatment with empagliflozin was beneficial in people with heart failure with preserved ejection fraction: plain language summary of the EMPEROR-Preserved study. Future Cardiol. 2023 Nov;19(14):671-677. doi: 10.2217/fca-2023-0091. Epub 2023 Nov 9.

    PubMed 37942723

  • Packer M, Butler J, Zeller C, Pocock SJ, Brueckmann M, Ferreira JP, Filippatos G, Usman MS, Zannad F, Anker SD. Blinded Withdrawal of Long-Term Randomized Treatment With Empagliflozin or Placebo in Patients With Heart Failure. Circulation. 2023 Sep 26;148(13):1011-1022. doi: 10.1161/CIRCULATIONAHA.123.065748. Epub 2023 Aug 24.

    PubMed 37621153

  • Butler J, Usman MS, Filippatos G, Ferreira JP, Bohm M, Brueckmann M, Januzzi JL, Kaul S, Pina IL, Ponikowski P, Senni M, Sumin M, Verma S, Zaremba-Pechmann L, Pocock SJ, Packer M, Anker S. Safety and Efficacy of Empagliflozin and Diuretic Use in Patients with Heart Failure and Preserved Ejection Fraction: A Post Hoc Analysis of the EMPEROR-Preserved Trial. JAMA Cardiol. 2023 Jul 1;8(7):640-649. doi: 10.1001/jamacardio.2023.1090.

    PubMed 37223933

  • Bhm M, Anker S, Mahfoud F, Lauder L, Filippatos G, Ferreira JP, Pocock SJ, Brueckmann M, Saloustros I, Schler E, Wanner C, Zannad F, Packer M, Butler J. Empagliflozin, irrespective of blood pressure, improves outcomes in heart failure with preserved ejection fraction: the EMPEROR-Preserved trial. Eur Heart J. 2023 Feb 1;44(5):396-407. doi: 10.1093/eurheartj/ehac693.

    PubMed 36478225

  • Ferreira JP, Zannad F, Butler J, Filippatos G, Pocock SJ, Brueckmann M, Steubl D, Schueler E, Anker SD, Packer M. Association of Empagliflozin Treatment With Albuminuria Levels in Patients With Heart Failure: A Secondary Analysis of EMPEROR-Pooled. JAMA Cardiol. 2022 Nov 1;7(11):1148-1159. doi: 10.1001/jamacardio.2022.2924.

    PubMed 36129693

  • Butler J, Filippatos G, Siddiqi TJ, Ferreira JP, Brueckmann M, Bocchi E, Bohm M, Chopra VK, Giannetti N, Iwata T, Januzzi JL, Kaul S, Pina IL, Ponikowski P, Rauch-Krohnert U, Shah SJ, Senni M, Sumin M, Verma S, Zhang J, Pocock SJ, Zannad F, Packer M, Anker SD. Effects of Empagliflozin in Women and Men With Heart Failure and Preserved Ejection Fraction. Circulation. 2022 Oct 4;146(14):1046-1055. doi: 10.1161/CIRCULATIONAHA.122.059755. Epub 2022 Sep 13.

    PubMed 36098051

  • Zannad F, Ferreira JP, Butler J, Filippatos G, Januzzi JL, Sumin M, Zwick M, Saadati M, Pocock SJ, Sattar N, Anker SD, Packer M. Effect of empagliflozin on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme. Eur Heart J. 2022 Dec 21;43(48):4991-5002. doi: 10.1093/eurheartj/ehac495.

    PubMed 36017745

  • Filippatos G, Butler J, Farmakis D, Zannad F, Ofstad AP, Ferreira JP, Green JB, Rosenstock J, Schnaidt S, Brueckmann M, Pocock SJ, Packer M, Anker SD; EMPEROR-Preserved Trial Committees and Investigators. Empagliflozin for Heart Failure With Preserved Left Ventricular Ejection Fraction With and Without Diabetes. Circulation. 2022 Aug 30;146(9):676-686. doi: 10.1161/CIRCULATIONAHA.122.059785. Epub 2022 Jun 28.

    PubMed 35762322

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Empagliflozin in people with Heart Failure, run by Boehringer Ingelheim at 619 sites in 23 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 6 Jun 2022. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 619 sites in United States, Japan, Argentina, Brazil, Germany and 18 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

Yes. Results are posted in the registry (first posted 6 Jun 2022). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Time to First Event of Adjudicated Cardiovascular (CV) Death or Adjudicated Hospitalisation for Heart Failure (HHF) (time frame: From randomization until completion of the planned treatment phase, up to 1403 days.). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT03057951, which also lists 23 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jun 2022.

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