AzTrials
AzTrials

HealthyNCT03033953

Effects of Native Whey or Milk Supplementation on Adaptations to 12 Weeks of Strength Training in Young and Elderly

A study testing Native whey, Milk and Strength training in people with Healthy and Young, run by Norwegian School of Sport Sciences at 1 site in Norway.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The aim of this study is to investigate the long term adaptations to 11 (elderly) or 12 (young) weeks of strength training when supplemented with native whey or milk. The investigators hypothesize that native whey will give greater increases in muscle hypertrophy and strength than milk. Read more about this study

Who is it for?
Ages 20 years and olderHealthy volunteers can take part
Conditions the study is for
Healthy, Young, Elderly
What is being tested?
Native whey, Milk and Strength training
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
66 participants
Where
1 siteNorway
Study dates
Aug 2014to Nov 2016
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 years and older
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • Healthy in the sense that they can conduct training and testing
  • Able to understand Norwegian language written and oral
  • Between 20 and 45, or above 70 years of age

Who cannot join

  • Diseases or injuries contraindicating participation
  • Use of dietary supplements (e.g. proteins, vitamins and creatine)
  • Lactose intolerance
  • Allergy to milk
  • Allergy towards local anesthetics (xylocain)

Trial locations and contacts

1 site in 1 country.

Norway1 site

  • Norwegian School of Sport Sciences

    Oslo, Oslo, 0863

Other trials in Norway

About this study

Official title: Effects of Native Whey and Milk Supplementation on Changes in Muscle Mass and Strength After 12 Weeks of Strength Training in Young and Elderly

The aim of this study is to investigate the long term adaptations to 11 (elderly) or 12 (young) weeks of strength training when supplemented with native whey or milk. The investigators hypothesize that native whey will give greater increases in muscle hypertrophy and strength than milk.

Read the detailed description

Increasing or maintaining muscle mass is of great importance for populations ranging from athletes to patients and elderly. Resistance exercise and protein ingestion are two of the most potent stimulators of muscle protein synthesis. Both the physical characteristic of proteins (e.g. different digestion rates of whey and casein) and the amino acid composition, affects the potential of a certain protein to stimulate muscle protein synthesis. Given its superior ability to rapidly increase blood leucine concentrations to high levels, whey is often considered the most potent protein source to stimulate muscle protein synthesis. Native whey protein is produced by filtration of unprocessed milk. Consequently, native whey has different characteristics than milk. Of special interest is the higher amounts of the highly anabolic amino acid leucine in native whey.

The higher levels of leucine can be of great interest for elderly individuals as some studies in elderly has shown an anabolic resistance to the effects of protein feeding and strength training. By increasing levels of leucine one might overcome this anabolic resistance in the elderly.

The aim of this double-blinded, randomized, partial cross-over study is to compare the changes in muscle hypertrophy and strength after a 11 (elderly) or 12 (young) week training intervention with daily supplementation of either 2x20g of native whey or milk proteins in young and elderly individuals. In order to explain potential differences between supplements an acute study investigating acute responses in blood amino acid concentrations and intracellular signalling is planned, in a subgroup of participants, before and after the training intervention.

The investigators hypothesize that native whey will induce greater muscle hypertrophy and strength gains than milk.

Conditions
Healthy, Young, Elderly
Being tested
Native whey, Milk, Strength training

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Native wheyDietary supplement

  • MilkDietary supplement

  • Strength trainingOther

Study groups in NCT03033953
Study groupRoleWhat they receive
Milk supplementationPlacebo comparator11 (elderly) or 12 (young) weeks of strength training and daily supplementation of 2x20g milk protein.
Receives: Dietary Supplement: Milk; Other: Strength training
Native wheyExperimental11 (elderly) or 12 (young) weeks of strength training and daily supplementation of 2x20g native whey protein.
Receives: Dietary Supplement: Native whey; Other: Strength training

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Lean mass

    Measured by whole body dual x-ray absorptiometry (DXA)

    Measured: Before the training intervention

  2. Lean mass

    Measured by whole body dual x-ray absorptiometry (DXA)

    Measured: After 11-12 weeks of strength training

Secondary outcomes (226)

  1. Thigh muscle cross sectional area

    Measured by magnetic resonance imaging (MRI)

    Measured: Before the training intervention

  2. Thigh muscle cross sectional area

    Measured by magnetic resonance imaging (MRI)

    Measured: After 11-12 weeks of strength training

  3. Pectoralis muscle cross sectional area

    Measured by magnetic resonance imaging (MRI)

    Measured: Before the training intervention

  4. Pectoralis muscle cross sectional area

    Measured by magnetic resonance imaging (MRI)

    Measured: After 11-12 weeks of strength training

  5. Arm cross sectional area

    Measured by magnetic resonance imaging (MRI)

    Measured: Before the training intervention

  6. Arm cross sectional area

    Measured by magnetic resonance imaging (MRI)

    Measured: After 11-12 weeks of strength training

  7. Thickness of the lateral vasti

    Measured by ultrasound

    Measured: Before the training intervention

  8. Thickness of the lateral vasti

    Measured by ultrasound

    Measured: After 11-12 weeks of strength training

  9. 1 repetition maximum in leg press

    Measured: Before the training intervention

  10. 1 repetition maximum in leg press

    Measured: After 11-12 weeks of strength training

  11. 1 repetition maximum in bench press

    Measured: Before the training intervention

  12. 1 repetition maximum in bench press

    Measured: After 11-12 weeks of strength training

  13. Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline

    Biopsies from m. Vastus Lateralis was analyzed by western blot

    Measured: 30 min before and 2 hours after exercise and protein supplement intake, before the training intervention

  14. Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline

    Biopsies from m. Vastus Lateralis was analyzed by western blot

    Measured: 30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training

  15. Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline

    Biopsies from m. Vastus Lateralis was analyzed by western blot

    Measured: 30 min before and 2 hours after exercise and protein supplement intake, before the training intervention

  16. Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline

    Biopsies from m. Vastus Lateralis was analyzed by western blot

    Measured: 30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training

  17. Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) change from baseline

    Biopsies from m. Vastus Lateralis was analyzed by western blot

    Measured: 30 min before and 2 hours after exercise and protein supplement intake, before the training intervention

  18. Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) change from baseline

    Biopsies from m. Vastus Lateralis was analyzed by western blot

    Measured: 30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training

  19. Plasma amino acid concentration

    Measured: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention

  20. Plasma amino acid concentration

    Measured: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training

  21. Muscle force generating capacity change from baseline

    Measured as unilateral isometric knee extension force (Nm) with 90° in the hip and knee joints.

    Measured: 15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, before the training intervention

  22. Muscle force generating capacity change from baseline

    Measured as unilateral isometric knee extension force (Nm) with 90° in the hip and knee joints.

    Measured: 15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, after 11-12 weeks of strength training

  23. Serum glucose

    Measured: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention

  24. Serum glucose

    Measured: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training

  25. Serum insulin

    Measured: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention

  26. Serum insulin

    Measured: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training

  27. Serum urea

    Measured: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention

  28. Serum urea

    Measured: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training

  29. Serum creatine kinase

    Measured: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention

  30. Serum creatine kinase

    Measured: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training

  31. Tumor necrosis factor alfa messenger ribonucleic acid (mRNA)

    Measured: 30 min before exercise and protein intake, before training intervention

  32. Tumor necrosis factor alfa mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  33. Tumor necrosis factor alfa mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  34. Tumor necrosis factor alfa mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  35. Interleukin 6 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  36. Interleukin 6 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  37. Interleukin 6 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  38. Interleukin 6 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  39. Interleukin 8 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  40. Interleukin 8 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  41. Interleukin 8 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  42. Interleukin 8 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  43. Nuclear Receptor Subfamily 4 Group A Member 2 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  44. Nuclear Receptor Subfamily 4 Group A Member 2 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  45. Nuclear Receptor Subfamily 4 Group A Member 2 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  46. Nuclear Receptor Subfamily 4 Group A Member 2 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  47. Interleukin 1b mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  48. Interleukin 1b mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  49. Interleukin 1b mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  50. Interleukin 1b mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  51. Interleukin 1 Receptor Antagonist mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  52. Interleukin 1 Receptor Antagonist mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  53. Interleukin 1 Receptor Antagonist mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  54. Interleukin 1 Receptor Antagonist mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  55. C-C Motif Chemokine Ligand 2 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  56. C-C Motif Chemokine Ligand 2 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  57. C-C Motif Chemokine Ligand 2 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  58. C-C Motif Chemokine Ligand 2 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  59. Interleukin 4 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  60. Interleukin 4 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  61. Interleukin 4 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  62. Interleukin 4 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  63. Interleukin 10 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  64. Interleukin 10 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  65. Interleukin 10 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  66. Interleukin 10 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  67. C-X-C Motif Chemokine Ligand mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  68. C-X-C Motif Chemokine Ligand mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  69. C-X-C Motif Chemokine Ligand mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  70. C-X-C Motif Chemokine Ligand mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  71. Cholesterol 25-Hydroxylase mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  72. Cholesterol 25-Hydroxylase mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  73. Cholesterol 25-Hydroxylase mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  74. Cholesterol 25-Hydroxylase mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  75. C-C Motif Chemokine Ligand 8 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  76. C-C Motif Chemokine Ligand 8 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  77. C-C Motif Chemokine Ligand 8 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  78. C-C Motif Chemokine Ligand 8 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  79. Interleukin 17D mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  80. Interleukin 17D mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  81. Interleukin 17D mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  82. Interleukin 17D mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  83. C-C Motif Chemokine Ligand 3 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  84. C-C Motif Chemokine Ligand 3 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  85. C-C Motif Chemokine Ligand 3 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  86. C-C Motif Chemokine Ligand 3 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  87. Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  88. Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  89. Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  90. Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  91. C-X-C Motif Chemokine Ligand 16 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  92. C-X-C Motif Chemokine Ligand 16 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  93. C-X-C Motif Chemokine Ligand 16 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  94. C-X-C Motif Chemokine Ligand 16 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  95. C-C Motif Chemokine Ligand 5 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  96. C-C Motif Chemokine Ligand 5 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  97. C-C Motif Chemokine Ligand 5 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  98. C-C Motif Chemokine Ligand 5 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  99. Nuclear Receptor Subfamily 4 Group A Member 3 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  100. Nuclear Receptor Subfamily 4 Group A Member 3 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  101. Nuclear Receptor Subfamily 4 Group A Member 3 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  102. Nuclear Receptor Subfamily 4 Group A Member 3 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  103. Uncoupling Protein 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  104. Uncoupling Protein 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  105. Uncoupling Protein 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  106. Uncoupling Protein 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  107. Matrix Metallopeptidase 9 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  108. Matrix Metallopeptidase 9 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  109. Matrix Metallopeptidase 9 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  110. Matrix Metallopeptidase 9 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  111. ATP Binding Cassette Subfamily A Member 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  112. ATP Binding Cassette Subfamily A Member 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  113. ATP Binding Cassette Subfamily A Member 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  114. ATP Binding Cassette Subfamily A Member 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  115. Leukocyte Differentiation Antigen CD36 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  116. Leukocyte Differentiation Antigen CD36 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  117. Leukocyte Differentiation Antigen CD36 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  118. Leukocyte Differentiation Antigen CD36 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  119. Toll Like Receptor 2 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  120. Toll Like Receptor 2 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  121. Toll Like Receptor 2 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  122. Toll Like Receptor 2 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  123. Nuclear Receptor Subfamily 1 Group H Member 3 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  124. Nuclear Receptor Subfamily 1 Group H Member 3 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  125. Nuclear Receptor Subfamily 1 Group H Member 3 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  126. Nuclear Receptor Subfamily 1 Group H Member 3 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  127. Solute Carrier Family 3 Member 2 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  128. Solute Carrier Family 3 Member 2 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  129. Solute Carrier Family 3 Member 2 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  130. Solute Carrier Family 3 Member 2 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  131. Solute Carrier Family 7 Member 5 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  132. Solute Carrier Family 7 Member 5 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  133. Solute Carrier Family 7 Member 5 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  134. Solute Carrier Family 7 Member 5 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  135. Solute Carrier Family 36 Member 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  136. Solute Carrier Family 36 Member 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  137. Solute Carrier Family 36 Member 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  138. Solute Carrier Family 36 Member 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  139. Solute Carrier Family 38 Member 2 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  140. Solute Carrier Family 38 Member 2 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  141. Solute Carrier Family 38 Member 2 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  142. Solute Carrier Family 38 Member 2 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  143. Muscle-Specific RING Finger Protein 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  144. Muscle-Specific RING Finger Protein 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  145. Muscle-Specific RING Finger Protein 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  146. Muscle-Specific RING Finger Protein 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  147. Atrogin-1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  148. Atrogin-1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  149. Atrogin-1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  150. Atrogin-1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  151. Forkhead Box Protein O1A mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  152. Forkhead Box Protein O1A mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  153. Forkhead Box Protein O1A mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  154. Forkhead Box Protein O1A mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  155. Forkhead Box O3 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  156. Forkhead Box O3 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  157. Forkhead Box O3 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  158. Forkhead Box O3 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  159. Myosin Heavy Chain 7 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  160. Myosin Heavy Chain 7 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  161. Myosin Heavy Chain 7 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  162. Myosin Heavy Chain 7 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  163. Myosin Heavy Chain 2 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  164. Myosin Heavy Chain 2 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  165. Myosin Heavy Chain 2 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  166. Myosin Heavy Chain 2 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  167. Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  168. Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  169. Myosin Heavy Chain 1mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  170. Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  171. Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  172. Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  173. Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  174. Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  175. Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  176. Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  177. Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  178. Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  179. Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  180. Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  181. Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  182. Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  183. Myostatin mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  184. Myostatin mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  185. Myostatin mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  186. Myostatin mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  187. Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  188. Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  189. Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  190. Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  191. JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  192. JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  193. JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  194. JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  195. Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  196. Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  197. Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  198. Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  199. Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  200. Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  201. Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  202. Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  203. Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  204. Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  205. Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  206. Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  207. TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  208. TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  209. TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  210. TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  211. Filamin B mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  212. Filamin B mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  213. Filamin B mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  214. Filamin B mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, after 11-12 weeks of strength training

  215. Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, before training intervention

  216. Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA

    Measured: 2 hours after exercise and protein intake, before training intervention

  217. Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min before exercise and protein intake, after 11-12 weeks of strength training

  218. Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA

    Measured: 30 min after exercise and protein intake, after 11-12 weeks of strength training

  219. Fasting cholesterol (only in elderly)

    Measured: Before training intervention

  220. Fasting cholesterol (only in elderly)

    Measured: After 11-12 weeks of strength training

  221. Fasting triglycerides (only in elderly)

    Measured: Before training intervention

  222. Fasting triglycerides (only in elderly)

    Measured: After 11-12 weeks of strength training

  223. Fasting LDL (only in elderly)

    Measured: Before training intervention

  224. Fasting LDL (only in elderly)

    Measured: After 11-12 weeks of strength training

  225. Fasting HDL (only in elderly)

    Measured: Before training intervention

  226. Fasting HDL (only in elderly)

    Measured: After 11-12 weeks of strength training

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 Jan 2017 (estimated)
  2. Study startAug 2014
  3. Primary completionJun 2015
  4. Study completionNov 2016

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Basic science
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
66 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT03033953
Sponsor's protocol ID
Tine 12wk
Status last verified
Jan 2017
First submitted
19 Jan 2017
Last updated
27 Jan 2017
Results posted
No
Data monitoring committee
No
Individual data sharing
Undecided

Questions about this trial

What is this clinical trial studying?

A study testing Native whey, Milk and Strength training in people with Healthy and Young, run by Norwegian School of Sport Sciences at 1 site in Norway.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 27 Jan 2017. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Norway. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Lean mass (time frame: Before the training intervention). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT03033953.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jan 2017.

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