AzTrials
AzTrials

Cardiovascular DiseasesPhase 3CLEAR OutcomesNCT02993406

Evaluation of Major Cardiovascular Events in Participants With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo

A Phase 3 study testing Bempedoic acid 180 mg tablet in people with Cardiovascular Diseases and Statin Adverse Reaction, run by Esperion Therapeutics, Inc. at 1,319 sites in 32 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

The purpose of this study is to determine if treatment with bempedoic acid (ETC-1002) versus placebo decreases the risk of cardiovascular events in participants who have or are at high risk for cardiovascular disease and are statin intolerant. Read more about this study

Who is it for?
Ages 18 to 85 years
What is being tested?
Bempedoic acid 180 mg tablet
Type of treatment
Pill or oral medicine
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
13,970 participants
Where
1,319 sitesin 32 countries
Study dates
22 Dec 2016to 7 Nov 2022
Phase
Phase 3
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 85 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Age between 18 and 85 years
  • History of, or at high risk for, cardiovascular disease (CVD) including coronary artery disease, symptomatic peripheral arterial disease, cerebrovascular atherosclerotic disease, or at high risk for a cardiovascular event
  • Participant-reported SI due to an adverse safety effect that started or increased during statin therapy and resolved or improved when statin therapy was discontinued resulting in an inability to tolerate:
  • 2 or more statins at any dose, or
  • 1 statin at any dose and unwilling to attempt a second statin or advised by a physician to not attempt a second statin.
  • Please note that participants currently tolerating very low dose statin therapy (an average daily dose of rosuvastatin <5 mg, atorvastatin <10 mg, simvastatin <10 mg, lovastatin <20 mg, pravastatin <40 mg, fluvastatin <40 mg, or pitavastatin <2 mg) are considered to be intolerant to that low dose statin. Patients may continue taking very low dose statin therapy throughout the study provided that it is stable (used for at least 4 weeks prior to screening) and well tolerated.
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  • Written confirmation by both participant and investigator that the participant is statin intolerant as defined above, aware of the benefit of statin use to reduce the risk of MACE including death, and also aware that many other participants who are unable to tolerate a statin are able to tolerate a different statin or dose.
  • Men and nonpregnant, nonlactating women
  • Fasting blood LDL-cholesterol ≥ 100 (2.6 mmol/L) at screening

Who cannot join

  • Fasting blood triglycerides greater than 500 mg/dL (5.6 mmol/L) at screening
  • Recent (within 90 days of screening) history of major cardiovascular events, transient ischemic attack (TIA), or unstable or symptomatic cardiac arrhythmia
  • History of severe heart failure
  • Uncontrolled hypertension or uncontrolled diabetes

Trial locations and contacts

1,319 sites in 32 countries.

1315 sites in 32 countries

United States300 sites

  • Study site

    Abington, Pennsylvania, 19001

  • Study site

    Akron, Ohio, 44304

  • Study site

    Akron, Ohio, 44311

  • Study site

    Albany, New York, 12211

  • Study site

    Allen, Texas, 75013

  • Study site

    Amarillo, Texas, 79106

  • Study site

    Anderson, Indiana, 46011

  • Study site

    Anderson, South Carolina, 29621-2062

  • Study site

    Anderson, South Carolina, 29621

  • Study site

    Annapolis, Maryland, 21401

  • Study site

    Asheboro, North Carolina, 27203

  • Study site

    Atlanta, Georgia, 30322

  • Study site

    Aurora, Colorado, 80012

  • Seton Heart Institute

    Austin, Texas, 78705

  • Study site

    Baltimore, Maryland, 21218

  • Study site

    Baltimore, Maryland, 21228

  • Study site

    Baltimore, Maryland, 21229

  • Study site

    Baltimore, Maryland, 21237

  • Study site

    Beaver, Pennsylvania, 15009

  • Study site

    Bellevue, Washington, 98004

  • Study site

    Beverly Hills, California, 90211

  • Study site

    Binghamton, New York, 13901

  • Study site

    Birmingham, Alabama, 35211

  • Study site

    Birmingham, Alabama, 35235

  • Study site

    Boca Raton, Florida, 33434

  • Study site

    Boynton Beach, Florida, 33435

  • Study site

    Boynton Beach, Florida, 33472

  • Study site

    Bradenton, Florida, 34209

  • Study site

    Bridgeton, Missouri, 63044

  • Study site

    Bridgeton, New Jersey, 08302

  • Study site

    Bridgewater, New Jersey, 08807

  • Study site

    Bronxville, New York, 10708

  • Study site

    Buckley, Michigan, 49620

  • Study site

    Buffalo, New York, 14215

  • Study site

    Burke, Virginia, 22015

  • Study site

    Burlington, North Carolina, 27215

  • Study site

    Cadillac, Michigan, 49601

  • Study site

    Camp Hill, Pennsylvania, 17011

  • Study site

    Canton, Ohio, 44710

  • Study site

    Carlsbad, California, 92008

  • Study site

    Caro, Michigan, 48723

  • Study site

    Cary, North Carolina, 27511

  • Study site

    Cary, North Carolina, 27518

  • Study site

    Champaign, Illinois, 61820

  • Study site

    Chandler, Arizona, 85224

  • Study site

    Charleston, South Carolina, 29407

  • Study site

    Charleston, South Carolina, 29425

  • Study site

    Charlotte, North Carolina, 28204

  • Study site

    Charlottesville, Virginia, 22903

  • Study site

    Chicago, Illinois, 60602

  • Study site

    Cincinnati, Ohio, 45236

  • Study site

    Clearwater, Florida, 33756

  • Study site

    Cleveland, Ohio, 44109

  • Study site

    Cleveland, Ohio, 44195

  • Study site

    Colorado Springs, Colorado, 80909

  • Study site

    Colorado Springs, Colorado, 80922

  • Study site

    Columbia, Maryland, 21044

  • Study site

    Columbus, Georgia, 31904

  • Study site

    Columbus, Ohio, 43210

  • Study site

    Columbus, Ohio, 43212

  • Study site

    Cottonwood, Arizona, 86326

  • Study site

    Council Bluffs, Iowa, 51501

  • Study site

    Covington, Georgia, 30014

  • Study site

    Crystal River, Florida, 34429

  • Study site

    Cumberland, Rhode Island, 02864

  • Study site

    Cumming, Georgia, 30041

  • Study site

    Dallas, Texas, 75226

  • Study site

    Dallas, Texas, 75231

  • Study site

    Dallas, Texas, 75234

  • Study site

    Dallas, Texas, 75235

  • Study site

    Danville, Virginia, 24541

  • Study site

    Dayton, Ohio, 45419

  • Study site

    DeSoto, Texas, 75115

  • Study site

    Dunwoody, Georgia, 30338

  • Study site

    Elizabethtown, Kentucky, 42701

  • Study site

    Elkhart, Indiana, 46514-2487

  • Study site

    Endwell, New York, 13760

  • Study site

    Eunice, Louisiana, 70535

  • Study site

    Evansville, Indiana, 47714

  • Study site

    Evansville, Indiana, 47715

  • Study site

    Falls Church, Virginia, 22042

  • Study site

    Fargo, North Dakota, 58103

  • Study site

    Farmington, Utah, 84025

  • Study site

    Fayetteville, Tennessee, 37334

  • Study site

    Fleming Island, Florida, 32003

  • Study site

    Flemington, New Jersey, 08822

  • Study site

    Fort Lauderdale, Florida, 33008

  • Study site

    Fort Lauderdale, Florida, 33308

  • Study site

    Fort Worth, Texas, 76107

  • Study site

    Fort Worth, Texas, 76132

  • Study site

    Fountain Hills, Arizona, 85268

  • Study site

    Franklin, Ohio, 45005

  • Study site

    Fremont, Nebraska, 68025

  • Study site

    Gainesville, Georgia, 30501

  • Study site

    Gilbert, Arizona, 85295

  • Study site

    Glendale, Arizona, 85306

  • Study site

    Glendale, Arizona, 85308

  • Study site

    Golden, Colorado, 80401

  • Study site

    Grand Blanc, Michigan, 48439

  • Study site

    Grand Rapids, Michigan, 49546

  • Study site

    Green Bay, Wisconsin, 54301

  • Study site

    Greenacres City, Florida, 33467

  • Study site

    Greeneville, Tennessee, 37745

  • Study site

    Greensboro, North Carolina, 27401

  • Study site

    Greensboro, North Carolina, 27408

  • Study site

    Greensboro, North Carolina, 27410

  • Study site

    Greer, South Carolina, 29651

  • Study site

    Gurnee, Illinois, 60031

  • Study site

    Haddon, New Jersey, 08035

  • Study site

    Hamden, Connecticut, 06517

  • Study site

    Hampton, Virginia, 23666

  • Study site

    Hartford, Connecticut, 06102

  • Study site

    Haverhill, Massachusetts, 01830

  • Study site

    Henderson, Nevada, 89052

  • Study site

    Hialeah, Florida, 33010

  • Study site

    Hialeah, Florida, 33012

  • Study site

    Hickory, North Carolina, 28601

  • Study site

    Houston, Texas, 77008

  • Study site

    Houston, Texas, 77030

  • Study site

    Houston, Texas, 77054

  • Study site

    Houston, Texas, 77074

  • Study site

    Huntington Beach, California, 92648-1717

  • Study site

    Huntsville, Alabama, 35802

  • Study site

    Hutchinson, Kansas, 67502

  • Study site

    Hyannis, Massachusetts, 02601

  • Study site

    Indianapolis, Indiana, 46237

  • Study site

    Indianapolis, Indiana, 46290

  • Study site

    Inverness, Florida, 34452

  • Study site

    Iowa City, Iowa, 52242

  • Study site

    Jackson, Tennessee, 38301

  • Study site

    Jackson Heights, New York, 11372

  • Study site

    Jacksonville, Florida, 32205

  • Study site

    Jacksonville, Florida, 32216

  • Study site

    Jacksonville, Florida, 32277

  • Study site

    Jamaica, New York, 11432

  • Study site

    Jerseyville, Illinois, 62052

  • Study site

    Johnstown, Pennsylvania, 15905

  • Study site

    Jupiter, Florida, 33458

  • Study site

    Kalamazoo, Michigan, 49009

  • Study site

    Kalispell, Montana, 59901

  • Study site

    Kansas City, Kansas, 66160

  • Study site

    Katy, Texas, 77450

  • Study site

    Kenosha, Wisconsin, 53144

  • Study site

    Kerrville, Texas, 78028

  • Study site

    Knoxville, Tennessee, 37918

  • Study site

    La Crosse, Wisconsin, 54601

  • Study site

    Lake Charles, Louisiana, 70601

  • Study site

    Lake Worth, Florida, 33461

  • Study site

    Lansing, Michigan, 48910

  • Study site

    Lansing, Michigan, 48912

  • Study site

    Largo, Florida, 33770

  • Study site

    Largo, Florida, 33777

  • Study site

    Las Vegas, Nevada, 89119

  • Study site

    Layton, Utah, 84041

  • Study site

    Lenoir, North Carolina, 28645

  • Study site

    Lexington, Kentucky, 40503

  • Study site

    Lincoln, California, 95648

  • Study site

    Lincoln, Nebraska, 68526

  • Study site

    Linden, New Jersey, 07036

  • Study site

    Little River, South Carolina, 29566

  • Study site

    Littleton, Colorado, 80120

  • Study site

    Long Beach, California, 90806

  • Study site

    Long Beach, California, 90807

  • Study site

    Louisville, Kentucky, 40213

  • Study site

    Loveland, Colorado, 80538

  • Study site

    Lubbock, Texas, 79410

  • Study site

    Macon, Georgia, 31201

  • Study site

    Madison, Wisconsin, 53713

  • Study site

    Manhasset, New York, 11030

  • Study site

    Marion, Ohio, 43302

  • Study site

    Maumee, Ohio, 43537

  • Study site

    McKinney, Texas, 75017

  • Study site

    McMurray, Pennsylvania, 15317

  • Study site

    Melbourne, Florida, 32934

  • Study site

    Meridian, Idaho, 83646

  • Study site

    Mesa, Arizona, 85206

  • Study site

    Miami, Florida, 33125

  • Study site

    Miami, Florida, 33126

  • Study site

    Miami, Florida, 33133

  • Study site

    Miami, Florida, 33144

  • Study site

    Miami, Florida, 33165

  • Study site

    Miami, Florida, 33172

  • Study site

    Miami, Florida, 33173

  • Study site

    Miami, Florida, 33175

  • Study site

    Miami, Florida, 33186

  • Study site

    Miami Lakes, Florida, 33016

  • Study site

    Middleburg Heights, Ohio, 44130

  • Study site

    Minneapolis, Minnesota, 55455

  • Study site

    Mobile, Alabama, 36608

  • Study site

    Mobile, Alabama, 36617

  • Study site

    Mooresville, North Carolina, 28117

  • Study site

    Morehead City, North Carolina, 28557

  • Study site

    Mount Clemens, Michigan, 48043

  • Study site

    Munster, Indiana, 46321

  • Study site

    Murray, Utah, 84123

  • Study site

    Naples, Florida, 34102

  • Study site

    Nashua, New Hampshire, 03060

  • Study site

    Natrona Heights, Pennsylvania, 15065

  • Study site

    New Orleans, Louisiana, 70121

  • Study site

    New Orleans, Louisiana, 70124

  • Study site

    New Port Richey, Florida, 34655

  • Study site

    New Windsor, New York, 12553

  • Study site

    New York, New York, 10029

  • Study site

    New York, New York, 10036

  • Study site

    Norfolk, Virginia, 23510

  • Study site

    Norman, Oklahoma, 73069

  • Study site

    North Haven, Connecticut, 06473

  • Study site

    North Miami Beach, Florida, 33162

  • Study site

    Northridge, California, 91324

  • Study site

    Ocala, Florida, 34471

  • Study site

    Oceanside, California, 92056

  • Study site

    Odessa, Texas, 79761

  • Study site

    Oklahoma City, Oklahoma, 73111

  • Study site

    Oklahoma City, Oklahoma, 73120

  • Study site

    Oklahoma City, Oklahoma, 73134

  • Study site

    Oklahoma City, Oklahoma, 73135

  • Study site

    Old Point Station, South Carolina, 29707

  • Study site

    Olympia Fields, Illinois, 60461

  • Study site

    Omaha, Nebraska, 68144

  • Study site

    Orem, Utah, 84058

  • Study site

    Orlando, Florida, 32825

  • Study site

    Ormond Beach, Florida, 32174

  • Study site

    Paducah, Kentucky, 42003

  • Study site

    Pearland, Texas, 77584

  • Study site

    Pell City, Alabama, 35125

  • Study site

    Pembroke Pines, Florida, 33025

  • Study site

    Pembroke Pines, Florida, 33026

  • Study site

    Pembroke Pines, Florida, 33027

  • Study site

    Petoskey, Michigan, 49770

  • Study site

    Phoenix, Arizona, 85020

  • Study site

    Phoenix, Arizona, 85050

  • Study site

    Pinellas Park, Florida, 33781

  • Study site

    Pittsburgh, Pennsylvania, 15236

  • Study site

    Plano, Texas, 75024

  • Study site

    Plano, Texas, 75093

  • Study site

    Ponte Vedra, Florida, 32081

  • Study site

    Port Charlotte, Florida, 33952

  • Study site

    Poughkeepsie, New York, 12601

  • Study site

    Providence, Rhode Island, 02906

  • Study site

    Raleigh, North Carolina, 27609

  • Study site

    Rancho Cucamonga, California, 91730

  • Study site

    Rapid City, South Dakota, 57701

  • Study site

    Rapid City, South Dakota, 57702

  • Study site

    Richfield, Minnesota, 55432

  • Study site

    Richmond, Indiana, 47374

  • Study site

    Roanoke, Virginia, 24014

  • Study site

    Rock Island, Illinois, 61201

  • Study site

    Rockford, Illinois, 61107

  • Study site

    Rockville, Maryland, 20850

  • Study site

    Rocky Mount, North Carolina, 27804

  • Study site

    Rocky Mount, North Carolina, 28404

  • Study site

    Safety Harbor, Florida, 34695

  • Study site

    Saginaw, Michigan, 48601

  • Study site

    Saint Cloud, Minnesota, 56303-1900

  • Study site

    Saint Paul, Minnesota, 55101

  • Study site

    Saint Paul, Minnesota, 55102

  • Study site

    Salisbury, Maryland, 21804

  • Study site

    San Angelo, Texas, 76904

  • Study site

    San Antonio, Texas, 78229

  • Study site

    San Antonio, Texas, 78230

  • Study site

    San Diego, California, 92108

  • Study site

    Sanford, North Carolina, 27330

  • Study site

    Santa Ana, California, 92705

  • Study site

    Santa Rosa, California, 95405

  • Study site

    Saratoga Springs, New York, 12866

  • Study site

    Savannah, Georgia, 31406

  • Study site

    Schertz, Texas, 78154

  • Study site

    Sewell, New Jersey, 08080

  • Study site

    Smithfield, Pennsylvania, 15478

  • Study site

    Southampton, New York, 11968

  • Study site

    St Louis, Missouri, 63128

  • Study site

    St Louis, Missouri, 63141

  • Study site

    St. Petersburg, Florida, 33713

  • Study site

    Stamford, Connecticut, 06905

  • Study site

    Sterling Heights, Michigan, 48312

  • Study site

    Suffolk, Virginia, 23435

  • Study site

    Sugar Land, Texas, 77479

  • Study site

    Summerville, South Carolina, 29485

  • Study site

    Tampa, Florida, 33624

  • Study site

    Teaneck, New Jersey, 07666

  • Study site

    Tomball, Texas, 77375

  • Study site

    Torrance, California, 90509

  • Study site

    Towson, Maryland, 21204

  • Study site

    Troy, Michigan, 48085

  • Study site

    Tucker, Georgia, 30084

  • Study site

    Tucson, Arizona, 85712

  • Study site

    Tucson, Arizona, 85741

  • Study site

    Tulsa, Oklahoma, 74133

  • Study site

    Tupelo, Mississippi, 38801

  • Study site

    Tuscumbia, Alabama, 35674

  • Study site

    Tyler, Texas, 75701

  • Study site

    Uniontown, Pennsylvania, 15401

  • Study site

    Victoria, Texas, 77901

  • Study site

    Vista, California, 92083

  • Study site

    Waterloo, Iowa, 50702

  • Study site

    Wellington, Florida, 33449

  • Study site

    West Des Moines, Iowa, 50266

  • Study site

    West Monroe, Louisiana, 71291

  • Study site

    Wichita, Kansas, 67205-1138

  • Study site

    Wilmington, North Carolina, 28401

Other trials in United States

Brazil84 sites

  • Study site

    Balneário Camboriú, Santa Catarina, 88331-085

  • Study site

    Bela Vista, 1323

  • Study site

    Belém, Pará, 66073-000

  • Study site

    Belo Horizonte, Minas Gerais, 30110-934

  • Study site

    Belo Horizonte, Minas Gerais, 30140-062

  • Study site

    Belo Horizonte, Minas Gerais, 30150-240

  • Study site

    Belo Horizonte, 30140

  • Study site

    Belo Horizonte, 30190

  • Study site

    Belo Horizonte, 31150221

  • Study site

    Bento Gonçalves, 95700068

  • Study site

    Blumenau, Santa Catarina, 89010-906

  • Study site

    Boa Vista, Recife, 50070

  • Study site

    Brasília, Federal District, 70200-730

  • Study site

    Brasília, Federal District, 70710-100

  • Study site

    Brasília, Federal District, 71655-175

  • Study site

    Brasília, 70658

  • Study site

    Campinas, São Paulo, 13010-001

  • Study site

    Campinas, São Paulo, 13020-431

  • Study site

    Campinas, São Paulo, 13060-080

  • Study site

    Campo Grande, Mato Grosso do Sul, 79080-190

  • Study site

    Caxias do Sul, Rio Grande Du Sul, 95070-560

  • Study site

    Cotia, São Paulo, 06717-100

  • Study site

    Curitiba, Paraná, 80030-110

  • Study site

    Curitiba, Paraná, 80030-480

  • Study site

    Curitiba, Paraná, 80060-900

  • Study site

    Curitiba, Paraná, 80730-150

  • Study site

    Curitiba, 80045

  • Study site

    Curitiba, 80230130

  • Study site

    Curitiba, 80730150

  • Study site

    Fortaleza, Ceará, 60160-230

  • Study site

    Fortaleza, Ceará, 60430-350

  • Study site

    Fortaleza, Ceará, 60430-370

  • Study site

    Fortaleza, Ceará, 60846-190

  • Study site

    Goiânia, Goiás, 74210-050

  • Study site

    Goiânia, Goiás, 74223-130

  • Study site

    Goiânia, 74093

  • Study site

    Jaú, São Paulo, 17210-190

  • Study site

    Joinville, 89227

  • Study site

    Maceió, 57051

  • Study site

    Marília, São Paulo, 17515-000

  • Study site

    Marília, 17515

  • Study site

    Maringá, 87015001

  • Study site

    Natal, Rio Grande do Norte, 59020-500

  • Study site

    Paraíso, São Paulo, 4005

  • Study site

    Passo Fundo, Rio Grande do Sul, 99010-080

  • Study site

    Porto Alegre, Rio Grande do Sul, 90035-170

  • Study site

    Porto Alegre, Rio Grande do Sul, 90510-040

  • Study site

    Porto Alegre, Rio Grande do Sul, 90620-001

  • Study site

    Porto Alegre, Rio Grande do Sul, 90840-440

  • Study site

    Porto Alegre, Rio Grande Du Sul, 90020-090

  • Study site

    Porto Alegre, 90035

  • Study site

    Porto Alegre, 91350200

  • Study site

    Recife, Pernambuco, 52051-380

  • Study site

    Rio de Janeiro, 22271-100

  • Study site

    Salvador, Estado de Bahia, 41950-275

  • Study site

    Salvador, 40050

  • Study site

    Salvador, 40110

  • Study site

    Salvador, 40170

  • Study site

    Salvador, 41820

  • Study site

    Santa Maria, Rio Grande do Sul, 97015-530

  • Study site

    Santa Maria, 97105

  • Study site

    Santo André, São Paulo, 09030-010

  • Study site

    Santo André, São Paulo, 09080-110

  • Study site

    Santo André, São Paulo, 09090-790

  • Study site

    São José, 88103

  • Study site

    São José do Rio Preto, São Paulo, 15015

  • Study site

    São José do Rio Preto, São Paulo, 15090-000

  • Study site

    São José dos Campos, São Paulo, 12243-280

  • Study site

    São Luís, 65077357

  • Study site

    São Paulo, Sau Paulo, 05403-000

  • Study site

    São Paulo, São Paulo, 01141-020

  • Study site

    São Paulo, São Paulo, 01221-020

  • Study site

    São Paulo, São Paulo, 01228-000

  • Study site

    São Paulo, São Paulo, 01244-030

  • Study site

    São Paulo, São Paulo, 01327-010

  • Study site

    São Paulo, São Paulo, 01406-200

  • Study site

    São Paulo, São Paulo, 01506-000

  • Study site

    São Paulo, São Paulo, 050017-000

  • Study site

    São Paulo, 08270-070

  • Study site

    São Paulo, 0

  • Study site

    Tatuí, São Paulo, 18270-170

  • Study site

    Uberlândia, Minas Gerais, 38411-186

  • Study site

    Vitória, Espírito Santo, 29055-450

  • Study site

    Votuporanga, São Paulo, 15500-003

Other trials in Brazil

Poland72 sites

  • Study site

    Bialystok, 15-445

  • Study site

    Brzozów, 36

  • Study site

    Bydgoszcz, 85-231

  • Study site

    Bydgoszcz, 85

  • Study site

    Chełm, 22-100

  • Study site

    Częstochowa, 42-202

  • Study site

    Elblag, 82-300

  • Study site

    Gdansk, 80-382

  • Study site

    Gdansk, 80-542

  • Study site

    Gdynia, 81-537

  • Study site

    Grodzisk Mazowiecki, 05-825

  • Study site

    Katowice, Silesian Voivodeship, 40-648

  • Study site

    Katowice, Sląskie, 40-018

  • Study site

    Katowice, Sląskie, 40-083

  • Study site

    Katowice, 40-040

  • Study site

    Katowice, 40

  • Study site

    Kielce, 25-364

  • Study site

    Krakow, Lesser Poland Voivodeship, 31-156

  • Study site

    Krakow, 30082

  • Study site

    Krakow, 31-261

  • Study site

    Krakow, 31

  • Study site

    Legnica, Lower Silesian Voivodeship, 59-220

  • Study site

    Legnica, 59

  • Study site

    Lodz, 15-445

  • Study site

    Lodz, 90-127

  • Study site

    Lodz, 90-302

  • Study site

    Lodz, 90-368

  • Study site

    Lodz, 90-549

  • Study site

    Lodz, 91-211

  • Study site

    Lodz, 93-513

  • Study site

    Lodz, 94-048

  • Study site

    Lublin, Lubelski, 20-091

  • Study site

    Lublin, 20-044

  • Study site

    Lublin, 20-709

  • Study site

    Nałęczów, 24-140

  • Study site

    Nowa Sól, 67-100

  • Study site

    Nowy Targ, 34

  • Study site

    Oświęcim, 32-600

  • Study site

    Płock, 09-400

  • Study site

    Poznan, 60-702

  • Study site

    Poznan, 60

  • Study site

    Poznan, 61-655

  • Study site

    Puławy, 24-100

  • Study site

    Ruda Śląska, Sląskie, 41-709

  • Study site

    Ruda Śląska, 41-709

  • Study site

    Ruda Śląska, 41

  • Study site

    Rzeszów, 35-006

  • Study site

    Rzeszów, 35-055

  • Study site

    Rzeszów, 35

  • Study site

    Siedlce, 08-110

  • Study site

    Skierniewice, 96-100

  • Study site

    Sopot, 81-717

  • Study site

    Staszów, 28-200

  • Study site

    Szczecin, 71-434

  • Study site

    Szczecin, 71-531

  • Study site

    Tarnów, Lesser Poland Voivodeship, 33-100

  • Study site

    Tarnów, 33

  • Study site

    Tczew, 83

  • Study site

    Torun, 87-100

  • Study site

    Warsaw, 00-465

  • Study site

    Warsaw, 01-192

  • Study site

    Warsaw, 02-793

  • Study site

    Warsaw, 04-730

  • Study site

    Włocławek, Kuyavian-Pomeranian Voivodeship, 87-800

  • Study site

    Włocławek, 87

  • Study site

    Wroclaw, Lower Silesian Voivodeship, 51-314

  • Study site

    Wroclaw, Lower Silesian Voivodeship, 53-301

  • Study site

    Wroclaw, 50-381

  • Study site

    Wroclaw, 50

  • Study site

    Wroclaw, 51

  • Study site

    Wroclaw, 53

  • Study site

    Zamość, 22-400

Other trials in Poland

Argentina71 sites

  • Study site

    Bahía Blanca, Buenos Aires, 8000

  • Study site

    Bahía Blanca, Buenos Aires, B8000FTD

  • Study site

    Bahía Blanca, Buenos Aires, B8001HXM

  • Study site

    Berazategui, Buenos Aires, 1884

  • Study site

    Buenos Aires, 1056

  • Study site

    Buenos Aires, 1406

  • Study site

    Buenos Aires, C1179AAB

  • Study site

    Buenos Aires, C1180AAX

  • Study site

    Buenos Aires, C1280AEB

  • Study site

    Buenos Aires, C1405BCK

  • Study site

    Buenos Aires, C1425AGC

  • Study site

    Caba, Ciudad Autonoma, C1419GEP

  • Study site

    Ciudad Autonoma Buenos Aires, C1118AAE

  • Study site

    Ciudad Autonoma Buenos Aires, C1128AAE

  • Study site

    Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1093AAS

  • Study site

    Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1119ACN

  • Study site

    Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1425DES

  • Study site

    Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1428ART

  • Study site

    Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1430CKE

  • Study site

    Ciudad Autónoma de Buenos Aires, Buenos Aires, 1426

  • Study site

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1179AAB

  • Study site

    Córdoba, Córdoba Province, 5000

  • Study site

    Córdoba, Córdoba Province, X50000EVQ

  • Study site

    Córdoba, Córdoba Province, X5003DCP

  • Study site

    Córdoba, 5008

  • Study site

    Córdoba, 5016

  • Study site

    Córdoba, X5000AAW

  • Study site

    Córdoba, X5000AOQ

  • Study site

    Córdoba, X5000BNB

  • Study site

    Córdoba, X5000JHQ

  • Study site

    Córdoba, X5003DCE

  • Study site

    Coronel Suárez, Buenos Aires, B7540GHD

  • Study site

    Corrientes, 3400

  • Study site

    Godoy Cruz, Mendoza Province, 5501

  • Study site

    Haedo, Buenos Aires, B1706CZA

  • Study site

    La Plata, Buenos Aires, B1900AXI

  • Study site

    La Plata, B1900EHD

  • Study site

    La Plata, B1902COS

  • Study site

    Lanus, B1824KAJ

  • Study site

    Mar del Plata, Buenos Aires, B7600FYK

  • Study site

    Mar del Plata, Buenos Aires, B7600FZ

  • Study site

    Mar del Plata, Buenos Aires, B7600GNY

  • Study site

    Mar del Plata, Buenos Aires, B7602CBM

  • Study site

    Morón, Buenos Aires, 1708

  • Study site

    Morón, B1708GIK

  • Study site

    Pilar, B1629ODT

  • Study site

    Quilmes, B1878GEG

  • Study site

    Ramos Mejía, B1704ETD

  • Study site

    Rosario, Santa Fe Province, 2000

  • Study site

    Rosario, Santa Fe Province, CP2000

  • Study site

    Rosario, Santa Fe Province, S2000DIF

  • Study site

    Rosario, Santa Fe Province, S2000DNM

  • Study site

    Rosario, Sante Fe, 2000

  • Study site

    Rosario, S2000ORE

  • Study site

    Rosario, S2001ODA

  • Study site

    Salta, 4406

  • Study site

    San Fernando, Buenos Aires, B1646EBJ

  • Study site

    San Lorenzo, 2200

  • Study site

    San Martín, Buenos Aires, B1650CSQ

  • Study site

    San Miguel de Tucumán, Tucumán Province, T4000ICL

  • Study site

    San Miguel de Tucumán, Tucumán Province, T4000

  • Study site

    San Miguel de Tucumán, T4000ICL

  • Study site

    San Miguel de Tucumán, T4000IFL

  • Study site

    San Rafael, Mendoza Province, CP5600

  • Study site

    San Vicente, Córdoba Province, X5006CBI

  • Study site

    Santa Fe, S3000EOZ

  • Study site

    Santa Fe, S3000FWO

  • Study site

    Temperley, Partido De Lomas De Zamora, 1834

  • Study site

    Vicente López, Buenos Aires, 1602

  • Study site

    Villa Luro, Ciudad Autonoma Buenos Aires, C1440CFD

  • Study site

    Zárate, Buenos Aires, B2800DGH

Other trials in Argentina

Russia68 sites

  • Study site

    Arkhangelsk, 163001

  • Study site

    Barnaul, Altayskiy Kray, 656038

  • Study site

    Barnaul, 656038

  • Study site

    Chelyabinsk, 454021

  • Study site

    Chelyabinsk, 454091

  • Study site

    Ivanovo, 153012

  • Study site

    Kazan', 420012

  • Study site

    Kemerovo, 650000

  • Study site

    Kemerovo, 650002

  • Study site

    Kemerovo, 650055

  • Study site

    Kirov, 610014

  • Study site

    Kirov, 610027

  • Study site

    Kirovsk, 187340

  • Study site

    Krasnoyarsk, 660062

  • Study site

    Kursk, 305007

  • Study site

    Kursk, 305035

  • Study site

    Moscow, 109388

  • Study site

    Moscow, 111539

  • Study site

    Moscow, 115516

  • Study site

    Moscow, 117593

  • Study site

    Moscow, 119049

  • Study site

    Moscow, 119620

  • Study site

    Moscow, 121359

  • Study site

    Moscow, 125299

  • Study site

    Moscow, 125367

  • Study site

    Moscow, 129090

  • Study site

    Moscow, 129301

  • Study site

    Nizhny Novgorod, 603011

  • Study site

    Novosibirsk, 630051

  • Study site

    Novosibirsk, 630068

  • Study site

    Novosibirsk, 630089

  • Study site

    Novosibirsk, 630117

  • Study site

    Omsk, 644018

  • Study site

    Omsk, 644024

  • Study site

    Orenburg, 460000

  • Study site

    Perm, 614097

  • Study site

    Rostov-on-Don, 344068

  • Study site

    Ryazan, 390026

  • Study site

    Ryazan, 390039

  • Study site

    Saint Petersburg, 192148

  • Study site

    Saint Petersburg, 192283

  • Study site

    Saint Petersburg, 193318

  • Study site

    Saint Petersburg, 194044

  • Study site

    Saint Petersburg, 194156

  • Study site

    Saint Petersburg, 195067

  • Study site

    Saint Petersburg, 195220

  • Study site

    Saint Petersburg, 195271

  • Study site

    Saint Petersburg, 196084

  • Study site

    Saint Petersburg, 196105

  • Study site

    Saint Petersburg, 196601

  • Study site

    Saint Petersburg, 197022

  • Study site

    Saint Petersburg, 197341

  • Study site

    Saint Petersburg, 197376

  • Study site

    Saint Petersburg, 198205

  • Study site

    Saint Petersburg, 198328

  • Study site

    Saint Petersburg, 198510

  • Study site

    Saint Petersburg, 199106

  • Study site

    Saratov, 410012

  • Study site

    Sestroretsk, 197706

  • Study site

    Smolensk, 214019

  • Study site

    Tomsk, 634009

  • Study site

    Tomsk, 634012

  • Study site

    Yaroslavl, 150000

  • Study site

    Yaroslavl, 150030

  • Study site

    Yaroslavl, 150062

  • Study site

    Yekaterinburg, 620028

  • Study site

    Yekaterinburg, 620109

  • Study site

    Yekaterinburg, 620144

Other trials in Russia

Netherlands64 sites

  • Study site

    Alkmaar, 1815 JD

  • Study site

    Almelo, 7609 PP

  • Study site

    Almere Stad, 1311 RL

  • Study site

    Amersfoort, 3813 TZ

  • Study site

    Amstelveen, 1186 AM

  • Study site

    Amsterdam, 1034 CS

  • Study site

    Amsterdam, 1066 EC

  • Study site

    Amsterdam, 1081 HV

  • Study site

    Amsterdam, 1091 AC

  • Study site

    Amsterdam, 1105 AZ

  • Study site

    Amsterdam

  • Study site

    Apeldoorn, 7334 DZ

  • Study site

    Apeldoorn

  • Study site

    Arnhem, 6815 AD

  • Study site

    Beverwijk, 1942 LE

  • Study site

    Blaricum, 1261 AN

  • Study site

    Delft, 2625 AD

  • Study site

    Dirksland, 3247 BW

  • Study site

    Doetinchem, 7009 BL

  • Study site

    Dordrecht, 3318 AT

  • Study site

    Ede, 6716 RP

  • Study site

    Eindhoven, 5623 EJ

  • Study site

    Enschede, 7512 KZ

  • Study site

    Goes, 4462 RA

  • Study site

    Gorinchem, 4204 AA

  • Study site

    Gouda, 2803 HH

  • Study site

    Gouda, 2803

  • Study site

    Hardenberg, 7772 SE

  • Study site

    Hardenberg, 7772

  • Study site

    Harderwijk

  • Study site

    Heerlen, 6419 PC

  • Study site

    Helmond, 5707 HA

  • Study site

    Hilversum, 1213 XZ

  • Study site

    Hoogeveen, 7909 AA

  • Study site

    Hoogezand, 9603 AE

  • Study site

    Hoorn, 1624 NP

  • Study site

    Leeuwarden, 8934 AD

  • Study site

    Leiden, 2333 ZA

  • Study site

    Leiderdorp, 2353 GA

  • Study site

    Maastricht, 6229 HX

  • Study site

    Nijmegen, 6525 GA

  • Study site

    Nijmegen, 6532 SZ

  • Study site

    Purmerend, 1441 RN

  • Study site

    Roosendaal, 4708 AE

  • Study site

    Rotterdam, 3037 AN

  • Study site

    Rotterdam, 3045 PM

  • Study site

    Rotterdam, 3067 GJ

  • Study site

    Rotterdam, 3079 DZ

  • Study site

    Rotterdam, 3083 AN

  • Study site

    Schiedam, 3118 JH

  • Study site

    Sneek

  • Study site

    The Hague, 2545 CH

  • Study site

    The Hague, 2565 KV

  • Study site

    The Hague, 2573 KH

  • Study site

    Tiel, 4002 WP

  • Study site

    Tilburg, 5022

  • Study site

    Utrecht, 3511 NH

  • Study site

    Utrecht, 3582 KE

  • Study site

    Utrecht, 3584 CX

  • Study site

    Venlo, 5912 BL

  • Study site

    Zutphen, 7207

  • Study site

    Zwijndrecht, 3331 LZ

  • Study site

    Zwijndrecht, 3334 SB

  • Study site

    Zwolle, 8025 AB

Other trials in Netherlands

Germany56 sites

  • Study site

    Altenburg, Saxony, 04600

  • Study site

    Bad Homburg, Hesse, 61348

  • Study site

    Bad Homburg, 61348

  • Study site

    Bad Krozingen, Baden-Wurttemberg, 79189

  • Study site

    Berlin, 10115

  • Study site

    Berlin, 10117

  • Study site

    Berlin, 10409

  • Study site

    Berlin, 10629

  • Study site

    Berlin, 10787

  • Study site

    Berlin, 12627

  • Study site

    Berlin, 13597

  • Study site

    Bielefeld, North Rhine-Westphalia, 33604

  • Study site

    Bielefeld, 33604

  • Study site

    Bochum, North Rhine-Westphalia, 44787

  • Study site

    Böhlen, Saxony, 04564

  • Study site

    Cologne, North Rhine-Westphalia, 50937

  • Study site

    Cologne, North Rhine-Westphalia, 51069

  • Study site

    Dippoldiswalde, Saxony, 01744

  • Study site

    Dortmund, North Rhine-Westphalia, 44137

  • Study site

    Dortmund, North Rhine-Westphalia, 44141

  • Study site

    Dresden, Baden-Wurttemberg, 01307

  • Study site

    Dresden, Saxony, 01099

  • Study site

    Dresden, Saxony, 01277

  • Study site

    Dresden, Saxony, 01279

  • Study site

    Dresden, Saxony, 01307

  • Study site

    Essen, North Rhine-Westphalia, 45355

  • Study site

    Essen, North Rhine-Westphalia, 45359

  • Study site

    Falkensee, 14612

  • Study site

    Frankfurt, 60389

  • Study site

    Frankfurt am Main, Hesse, 60313

  • Study site

    Frankfurt am Main, Hesse, 60594

  • Study site

    Frankfurt am Main, Hesse, 65929

  • Study site

    Goch, North Rhine-Westphalia, 47574

  • Study site

    Hamburg, 22041

  • Study site

    Hamburg, 22143

  • Study site

    Hamburg, 22607

  • Study site

    Hanover, 30159

  • Study site

    Heidelberg, Baden-Wurttemberg, 69115

  • Study site

    Heidelberg, 69120

  • Study site

    Kassel, Hesse, 34121

  • Study site

    Leipzig, Saxony, 04103

  • Study site

    Leipzig, Saxony, 04249

  • Study site

    Mainz, Hesse, 55128

  • Study site

    Mainz, Rhineland-Palatinate, 55131

  • Study site

    Mainz, D-55128

  • Study site

    Markkleeberg, Saxony, 04416

  • Study site

    Munich, Bavaria, 80809

  • Study site

    Reinfeld, 23858

  • Study site

    Rodgau, Hesse, 63110

  • Study site

    Schwerin, Mecklenburg-Vorpommern, 19055

  • Study site

    Siegen, North Rhine-Westphalia, 57072

  • Study site

    Soest, North Rhine-Westphalia, 59494

  • Study site

    Wallerfing, Bavaria, 94574

  • Study site

    Wermsdorf, Saxony, 04779

  • Study site

    Witten, North Rhine-Westphalia, 58455

  • Study site

    Zwenkau, Saxony, 04442

Other trials in Germany

Ukraine49 sites

  • Study site

    Brovary, 07400

  • Study site

    Cherkasy, 18009

  • Study site

    Chernivtsi, 58000

  • Study site

    Dnipro, 49005

  • Study site

    Dnipro, 49006

  • Study site

    Dnipro, 49023

  • Study site

    Dnipro, 49038

  • Study site

    Ivano-Frankivsk, 76008

  • Study site

    Ivano-Frankivsk, 76018

  • Study site

    Kharkiv, 61002

  • Study site

    Kharkiv, 61039

  • Study site

    Kharkiv, 61103

  • Study site

    Kharkiv, 61106

  • Study site

    Kharkiv, 61124

  • Study site

    Kharkiv, 61172

  • Study site

    Kharkiv, 61176

  • Study site

    Kyiv, 01023

  • Study site

    Kyiv, 01601

  • Study site

    Kyiv, 02002

  • Study site

    Kyiv, 02091

  • Study site

    Kyiv, 02166

  • Study site

    Kyiv, 02232

  • Study site

    Kyiv, 03037

  • Study site

    Kyiv, 03049

  • Study site

    Kyiv, 03110

  • Study site

    Kyiv, 03115

  • Study site

    Kyiv, 03680

  • Study site

    Kyiv, 04050

  • Study site

    Kyiv, 04053

  • Study site

    Lutsk, 43024

  • Study site

    Lviv, 79011

  • Study site

    Lviv, 79015

  • Study site

    Mykolaiv, 54003

  • Study site

    Odesa, 65025

  • Study site

    Sumy, 40021

  • Study site

    Ternopil, 46010

  • Study site

    Uzhhorod, 88014

  • Study site

    Vinnytsia, 21001

  • Study site

    Vinnytsia, 21005

  • Study site

    Vinnytsia, 21009

  • Study site

    Vinnytsia, 21018

  • Study site

    Vinnytsia, 21029

  • Study site

    Zaporizhzhya, 60106

  • Study site

    Zaporizhzhya, 69001

  • Study site

    Zaporizhzhya, 69005

  • Study site

    Zaporizhzhya, 69063

  • Study site

    Zaporizhzhya, 69104

  • Study site

    Zaporizhzhya, 69600

  • Study site

    Zhytomyr, 10002

Other trials in Ukraine

Romania46 sites

  • Study site

    Alba Iulia, 510053

  • Study site

    Baia Mare, Maramureş, 430032

  • Study site

    Baia Mare, 430032

  • Study site

    Baia Mare, 430222

  • Study site

    Baloteşti, 077015

  • Study site

    Brăila, 810249

  • Study site

    Brasov, 500283

  • Study site

    Brasov, 500326

  • Study site

    Bucharest, 010192

  • Study site

    Bucharest, 010825

  • Study site

    Bucharest, 020045

  • Study site

    Bucharest, 020125

  • Study site

    Bucharest, 021659

  • Study site

    Bucharest, 030088

  • Study site

    Bucharest, 030463

  • Study site

    Bucharest, 050659

  • Study site

    Bucharest, 062272

  • Study site

    Bucharest, 10825

  • Study site

    Bucharest, 20063

  • Study site

    Bucharest, 20614

  • Study site

    Bucharest, 4204178

  • Study site

    Calarasi, 910103

  • Study site

    Cluj-Napoca, 400496

  • Study site

    Craiova, 200500

  • Study site

    Deva, 330084

  • Study site

    Galati, 800001

  • Study site

    Galati, 800291

  • Study site

    Oradea, 410001

  • Study site

    Oradea, 410159

  • Study site

    Oradea, 410167

  • Study site

    Oradea, 410491

  • Study site

    Paşcani, 705200

  • Study site

    Piteşti, Argeş, 110084

  • Study site

    Piteşti, 110084

  • Study site

    Ploieşti, 100342

  • Study site

    Satu Mare, Satu Mare County, 440055

  • Study site

    Satu Mare, 440055

  • Study site

    Târgu Mureş, 540099

  • Study site

    Târgu Mureş, 540140

  • Study site

    Târgu Mureş, 540142

  • Study site

    Târgu Mureş, 540143

  • Study site

    Timișoara, Timiș County, 300456

  • Study site

    Timișoara, 300362

  • Study site

    Timișoara, 300456

  • Study site

    Timișoara, 300723

  • Study site

    Zalău, 450112

Other trials in Romania

Mexico43 sites

  • Study site

    Aguascalientes, 20010

  • Study site

    Aguascalientes, 20016

  • Study site

    Aguascalientes, 20230

  • Study site

    Chihuahua City, Chihuahua C.P., 31203

  • Study site

    Chihuahua City, 0

  • Study site

    Chihuahua City, 31217

  • Study site

    Chihuahua City, 4032

  • Study site

    Cuernavaca, 62250

  • Study site

    Culiacán, Sinaloa, 80200

  • Study site

    Culiacán, Sinaloa, 80230

  • Study site

    Durango, 34000

  • Study site

    Guadalajara, Jalisco, 44160

  • Study site

    Guadalajara, Jalisco, 44670

  • Study site

    Guadalajara, 44160

  • Study site

    Guadalajara, 44500

  • Study site

    Guadalajara, 44657

  • Study site

    Guadalajara, 44670

  • Study site

    Juárez, 32472

  • Study site

    Mazatlán, Sinaloa, 82110

  • Study site

    Mérida, Yucatán, 97129

  • Study site

    Mexico City, Mexico City, 03100

  • Study site

    Mexico City, Mexico City, 03300

  • Study site

    Mexico City, Mexico City, 06100

  • Study site

    Mexico City, Mexico City, 06700

  • Study site

    Mexico City, Mexico City, 11650

  • Study site

    Mexico City, 14080

  • Study site

    Mexico City, 3100

  • Study site

    Mexico City, 3720

  • Study site

    Mexico City, 7760

  • Study site

    Monclova, Coahuila, 25750

  • Study site

    Monterrey, Nuevo León, 64660

  • Study site

    Monterrey, 64060

  • Study site

    Monterrey, 64460

  • Study site

    Monterrey, 64718

  • Study site

    Pachuca, Hidalgo, 42090

  • Study site

    Pachuca, 42070

  • Study site

    Puerto Vallarta, 48328

  • Study site

    Querétaro, 76090

  • Study site

    Querétaro City, Querétaro, 76000

  • Study site

    Tamaulipas, C.P 89440

  • Study site

    Tijuana, Baja California Norte, 22500

  • Study site

    Torreón, Coahuila, 27000

  • Study site

    Veracruz, 91900

Other trials in Mexico

Hungary42 sites

  • Study site

    Baja, 6500

  • Study site

    Balatonfüred, H-8230

  • Study site

    Balatongyörök, 8313

  • Study site

    Békéscsaba, 5600

  • Study site

    Budapest, 1033

  • Study site

    Budapest, 1036

  • Study site

    Budapest, 1037

  • Study site

    Budapest, 1083

  • Study site

    Budapest, 1085

  • Study site

    Budapest, 1097

  • Study site

    Budapest, 1121

  • Study site

    Budapest, 1122

  • Study site

    Budapest, 1125

  • Study site

    Budapest, 1132

  • Study site

    Budapest, 1134

  • Study site

    Budapest, 1135

  • Study site

    Debrecen, 4025

  • Study site

    Debrecen, 4032

  • Study site

    Dombóvár, 7200

  • Study site

    Gyöngyös, 3200

  • Study site

    Győr, 9024

  • Study site

    Gyula, 5700

  • Study site

    Hajdúszoboszló, 4200

  • Study site

    Kalocsa, 6300

  • Study site

    Kecskemét, 8000

  • Study site

    Kiskunhalas, 6400

  • Study site

    Miskolc, 3530

  • Study site

    Mosonmagyaróvár, H-9200

  • Study site

    Nagykanizsa, 8800

  • Study site

    Nyíregyháza, 4400

  • Study site

    Nyíregyháza, H-4405

  • Study site

    Orosháza, Szentetornya, 5905

  • Study site

    Orosháza, 5905

  • Study site

    Pécs, 7623

  • Study site

    Pécs, 7635

  • Study site

    Polgár, 4090

  • Study site

    Székesfehérvár, 8000

  • Study site

    Szekszárd, 7100

  • Study site

    Szentendre, 2000

  • Study site

    Szentes, 6600

  • Study site

    Szombathely, 9700

  • Study site

    Zalaegerszeg, 8900

Other trials in Hungary

United Kingdom36 sites

  • Study site

    Airdrie, North Lanarkshire, ML6 0JS

  • Study site

    Axbridge, Somerset, BS26 2BJ

  • Study site

    Basildon, Essex, SS16 5NL

  • Study site

    Bath, Somerset, BA3 2UH

  • Study site

    Birmingham, West Midlands, B15 2SQ

  • Study site

    Blackpool, Lancashire, FY4 3AD

  • Study site

    Blackpool, FY3 7EN

  • Study site

    Cardiff, South Glamorgan, CF15 9SS

  • Study site

    Chertsey, Surrey, KT16 0PZ

  • Study site

    Chesterfield, S40 4AA

  • Study site

    Chorley, Lancashire, PR7 7NA

  • Study site

    Crownhill, PL5 3JB

  • Study site

    Dundee, Tayside Region, DD1 9SY

  • Study site

    East Kilbride, Lanarkshire, G75 8RG

  • Study site

    Edinburgh, Lothian Region, EH16 4SA

  • Study site

    Exmouth, Devon, EX8 2JF

  • Study site

    Fowey, Cornwall, PL23 1DT

  • Study site

    Glasgow, Strathclyde, G20 OSP

  • Study site

    Hayle, Cornwall, TR27 5DT

  • Study site

    Hexham, Northumberland, NE46 1QJ

  • Study site

    Lincoln, LN2 5QY

  • Study site

    Liverpool, Merseyside, L22 0LG

  • Study site

    London, Greater London, EC1M 6BQ

  • Study site

    Manchester, Greater Manchester, M15 6SX

  • Study site

    Oldham, OL1 2JH

  • Study site

    Plymouth, Devon, PL6 8DH

  • Study site

    Plymouth, Devon, PL7 2QP

  • Study site

    Reading, Berkshire, RG2 0TG

  • Study site

    Royal Leamington Spa, CV32 4RA

  • Study site

    Sandbach, CW11 1EQ

  • Study site

    Soham, Cambridgeshire, CB7 5JD

  • Study site

    Stockton-on-Tees, Durham, TS19 8PE

  • Study site

    Torpoint, Cornwall, PL11 2TB

  • Study site

    Wakefield, Yorkshire and the Humber, WF1 4DG

  • Study site

    Wakefield, Yorkshire, WF1 4DG

  • Study site

    Whitby, YO21 1SD

Other trials in United Kingdom

Czechia35 sites

  • Study site

    Benátky nad Jizerou, 294 71

  • Study site

    Beroun, 266 01

  • Study site

    Brandýs nad Labem, 25001

  • Study site

    Brno, 603 00

  • Study site

    Brno, 636 00

  • Study site

    Brno, 638 00

  • Study site

    Brno, 639 00

  • Study site

    Brno, 656 91

  • Study site

    Broumov, 550 01

  • Study site

    Choceň, 56501

  • Study site

    Chrudim, 53701

  • Study site

    Frýdek-Místek, 73801

  • Study site

    Havířov, 763 01

  • Study site

    Havlíčkův Brod, 580 22

  • Study site

    Hodonín, 69501

  • Study site

    Hradec Králové, 500 02

  • Study site

    Hradec Králové, 50005

  • Study site

    Kolín, 28000

  • Study site

    Náchod, 547 01

  • Study site

    Olomouc, 77900

  • Study site

    Ostrava, 70200

  • Study site

    Pardubice, 530 02

  • Study site

    Prague, 10100

  • Study site

    Prague, 11000

  • Study site

    Prague, 120 00

  • Study site

    Prague, 128 00

  • Study site

    Prague, 140 21

  • Study site

    Prague, 150 06

  • Study site

    Prague, 158 00

  • Study site

    Praha 4 - Krc, 140 59

  • Study site

    Přerov, 75002

  • Study site

    Slaný, 274 01

  • Study site

    Teplice, 41501

  • Study site

    Trutnov, 541 01

  • Study site

    Uherské Hradiště, 68601

Other trials in Czechia

India35 sites

  • Study site

    Ahmedabad, Gujarat, 380007

  • Study site

    Bangalore, Karnataka, 560010

  • Study site

    Bangalore, Karnataka, 560099

  • Study site

    Belagavi, Karnataka, 590010

  • Study site

    Bengaluru, Karnataka, 560074

  • Study site

    Chennai, Tamil Nadu, 600037

  • Study site

    Chhatrapati Sambhajinagar, Maharashtra, 431001

  • Study site

    Chhatrapati Sambhajinagar, Maharashtra, 431005

  • Study site

    Coimbatore, Tamil Nadu, 641009

  • Study site

    Delhi, 110062

  • Study site

    Faridabad, Haryana, 121001

  • Study site

    Gurgaon, Haryana, 122001

  • Study site

    Guwahati, Assam, 781006

  • Study site

    Hubli, Karnatak, 580021

  • Study site

    Hyderabad, Andhra Pradesh, 500034

  • Study site

    Jaipur, Rajasthan, 302001

  • Study site

    Jaipur, Rajasthan, 302020

  • Study site

    Kolkata, West Bengal, 700027

  • Study site

    Lucknow, Uttar Pradesh, 226010

  • Study site

    Nadiād, Gujarat, 387002

  • Study site

    Nagpur, Maharashtra, 440003

  • Study site

    Nagpur, Maharashtra, 440010

  • Study site

    Nagpur, Maharashtra, 440012

  • Study site

    Nashik, Maharashtra, 422005

  • Study site

    Nashik, Maharashtra, 422007

  • Study site

    New Delhi, National Capital Territory of Delhi, 110002

  • Study site

    New Delhi, National Capital Territory of Delhi, 110005

  • Study site

    New Delhi, National Capital Territory of Delhi, 110070

  • Study site

    Noida, Uttar Pradesh, 201301

  • Study site

    Pune, Maharashtra, 411001

  • Study site

    Pune, Maharashtra, 411004

  • Study site

    Pune, Maharashtra, 411005

  • Study site

    Surat, Gujarat, 395002

  • Study site

    Surat, Gujarat, 395009

  • Study site

    Vadodara, Gujarat, 391740

Other trials in India

South Africa35 sites

  • Study site

    Alberton, Guateng, 1449

  • Study site

    Bloemfontein, Free State, 9300

  • Study site

    Bloemfontein, Free State, 9301

  • Study site

    Cape Town, Western Cape, 7130

  • Study site

    Cape Town, Western Cape, 7405

  • Study site

    Cape Town, Western Cape, 7500

  • Study site

    Cape Town, Western Cape, 7570

  • Study site

    Cape Town, Western Cape, 7580

  • Study site

    Cape Town, Western Cape, 7764

  • Study site

    Cape Town, Western Cape, 7925

  • Study site

    Centurion, Gauteng, 0157

  • Study site

    Durban, KwaZulu-Natal, 4001

  • Study site

    Durban, KwaZulu-Natal, 4320

  • Study site

    Durban, KwaZulu-Natal, 4339

  • Study site

    Johannesburg, Gauteng, 1401

  • Study site

    Johannesburg, Gauteng, 2193

  • Study site

    Johannesburg, Gauteng, 2196

  • Study site

    Kempton Park, Gauteng, 1619

  • Study site

    Merebank, KwaZulu-Natal, 4052

  • Study site

    Middelburg, Mpumalanga, 1055

  • Study site

    Moloto South, Mpumalanga, 1022

  • Study site

    Port Elizabeth, Eastern Cape, 6001

  • Study site

    Port Elizabeth, Eastern Cape, 6014

  • Study site

    Pretoria, Gauteng, 0002

  • Study site

    Pretoria, Gauteng, 0040

  • Study site

    Pretoria, Gauteng, 0084

  • Study site

    Pretoria, Gauteng, 0087

  • Study site

    Pretoria, Gauteng, 0157

  • Study site

    Pretoria, Gauteng, 0184

  • Study site

    Pretoria, Gauteng, 1692

  • Study site

    Pretoria, Guateng, 0002

  • Study site

    Pretoria, Guateng, 0181

  • Study site

    Somerset West, Western Cape, 7130

  • Study site

    Thabazimbi, Limpopo, 0380

  • Study site

    Worcester, Western Cape, 6850

Other trials in South Africa

Bulgaria33 sites

  • Study site

    Blagoevgrad, 2700

  • Study site

    Byala, 7100

  • Study site

    Dimitrovgrad, 6400

  • Study site

    Haskovo, 6300

  • Study site

    Pazardzhik, 4400

  • Study site

    Pernik, 2300

  • Study site

    Pleven, 5800

  • Study site

    Plovdiv, 4000

  • Study site

    Plovdiv, 4002

  • Study site

    Rousse, 7000

  • Study site

    Rousse, 7013

  • Study site

    Sandanski, 2800

  • Study site

    Sliven, 8800

  • Study site

    Sofia, 1040

  • Study site

    Sofia, 1202

  • Study site

    Sofia, 1233

  • Study site

    Sofia, 1309

  • Study site

    Sofia, 1336

  • Study site

    Sofia, 1407

  • Study site

    Sofia, 1408

  • Study site

    Sofia, 1431

  • Study site

    Sofia, 1527

  • Study site

    Sofia, 1606

  • Study site

    Sofia, 1680

  • Study site

    Sofia, 1750

  • Study site

    Sofia, 1784

  • Study site

    Stara Zagora, 6000

  • Study site

    Stara Zagora, 6004

  • Study site

    Varna, 9000

  • Study site

    Varna, 9002

  • Study site

    Varna, 9020

  • Study site

    Veliko Tarnovo, 5000

  • Study site

    Yambol, 8600

Other trials in Bulgaria

Australia31 sites

  • Study site

    Adamstown, New South Wales, 2289

  • Study site

    Adelaide, South Australia, 5000

  • Study site

    Ashford, South Australia, 5035

  • Study site

    Auchenflower, Queensland, 4066

  • Study site

    Ballarat, Victoria, 3350

  • Study site

    Box Hill, Victoria, 3128

  • Study site

    Bundaberg, Queensland, 4670

  • Study site

    Camperdown, New South Wales, 2050

  • Study site

    Chermside, Queensland, 4032

  • Study site

    Clayton, Victoria, 3168

  • Study site

    Fitzroy, Victoria, 3065

  • Study site

    Frankston, Victoria, 3199

  • Study site

    Fullarton, South Australia, 5063

  • Study site

    Gosford, New South Wales, 2250

  • Study site

    Hobart, Tasmania, 7000

  • Study site

    Joondalup, Western Australia, 6027

  • Study site

    Langwarrin, Victoria, 3910

  • Study site

    Liverpool, New South Wales, 2170

  • Study site

    Melbourne, Victoria, 3004

  • Study site

    Merewether, New South Wales, 2291

  • Study site

    Mildura, Victoria, 3500

  • Study site

    Milton, Queensland, 4064

  • Study site

    Murdoch, Western Australia, 6150

  • Study site

    Nedlands, Western Australia, 6009

  • Study site

    Perth, Western Australia, 6000

  • Study site

    Sherwood, Queensland, 4075

  • Study site

    Sippy Downs, Queensland, 4556

  • Study site

    Subiaco, Western Australia, 6008

  • Study site

    Tumbi Vmbi, New South Wales, 2261

  • Study site

    Wollongong, New South Wales, 2522

  • Study site

    Woolloongabba, Queensland, 4102

Other trials in Australia

Slovakia26 sites

  • Study site

    Bardejov, 08501

  • Study site

    Bratislava, Ružinov, 82606

  • Study site

    Bratislava, 81104

  • Study site

    Bratislava, 83101

  • Study site

    Bratislava, 84108

  • Study site

    Bratislava, 85101

  • Study site

    Dolný Kubín, 02601

  • Study site

    Komárno, 94501

  • Study site

    Košice, 040 22

  • Study site

    Košice, 04001

  • Study site

    Košice, 04011

  • Study site

    Košice, 4001

  • Study site

    Levice, 93401

  • Study site

    Levice, 93405

  • Study site

    Ľubochňa, 3491

  • Study site

    Lučenec, 984 01

  • Study site

    Lučenec, 98401

  • Study site

    Moldava nad Bodvou, 045 01

  • Study site

    Nitra, 94901

  • Study site

    Nové Zámky, 94052

  • Study site

    Prešov, 08001

  • Study site

    Rožňava, 048 01

  • Study site

    Šahy, 93601

  • Study site

    Štúrovo, 943 01

  • Study site

    Svidník, 08901

  • Study site

    Žilina, 01001

Other trials in Slovakia

Canada25 sites

  • Study site

    Brampton, Ontario, L6T 0G1

  • Study site

    Brampton, Ontario, L6Z 4N5

  • Study site

    Cambridge, Ontario, N1R 6V6

  • Study site

    Cambridge, Ontario, N1R 7R1

  • Study site

    Chicoutimi, Quebec, G7H 7K9

  • Study site

    Greater Sudbury, Ontario, P3E 5M4

  • Study site

    London, Ontario, N5W 6A2

  • Study site

    Longueuil, Quebec, J4M 2X1

  • Study site

    Longueuil, Quebec, J4N 2H4

  • Study site

    Montreal, Quebec, H1T 1C8

  • Study site

    Montreal, Quebec, H1T 3Y7

  • Study site

    Mount Pearl, Newfoundland and Labrador, A1N 1W7

  • Study site

    Newmarket, Ontario, L3Y 5G8

  • Study site

    Oakville, Ontario, L6K 3W7

  • Study site

    Peterborough, Ontario, K9J 0B2

  • Study site

    Pointe-Claire, Quebec, H9R 3J1

  • Study site

    Québec, G1G 3Y8

  • Study site

    Québec, G1V 4G5

  • Study site

    Saint-Georges, Quebec, G5Y 4T8

  • Study site

    Saint-Jean-sur-Richelieu, Quebec, J3A 1J2

  • Study site

    Saint-Jérôme, Quebec, J7Z 5T3

  • Study site

    Sarnia, Ontario, N7T 4X3

  • Study site

    Toronto, Ontario, M9V 4B4

  • Study site

    Victoria, British Columbia, V8T 5G4

  • Study site

    Victoriaville, Quebec, G6P 6P6

Other trials in Canada

Colombia22 sites

  • Study site

    Barranquilla, 0000

  • Study site

    Barranquilla, 080020

  • Study site

    Barranquilla, 80020

  • Study site

    Bogotá, 1013

  • Study site

    Bogotá, 110221

  • Study site

    Bogotá, 110911

  • Study site

    Bogotá, 111111

  • Study site

    Bogotá, 111211

  • Study site

    Bucaramanga, 00000

  • Study site

    Bucaramanga, 681004

  • Study site

    Cali, 760035

  • Study site

    Cali, 760036

  • Study site

    Cartagena, 130010

  • Study site

    Cartagena, 13001

  • Study site

    Espinal, 00000

  • Study site

    Ibague, 730006

  • Study site

    Manizales, 170004

  • Study site

    Medellín, 00000

  • Study site

    Medellín, 050021

  • Study site

    Pereira, 00000

  • Study site

    San Gil, 00000

  • Study site

    Zipaquirá, 250252

Other trials in Colombia

Belgium21 sites

  • Study site

    Aalst, 9300

  • Study site

    Antwerp, 2020

  • Study site

    Antwerp, 2060

  • Study site

    Brasschaat, 2930

  • Study site

    Bruges, 8000

  • Study site

    Brussels, 1070

  • Study site

    Brussels, 1090

  • Study site

    De Pinte, 9840

  • Study site

    Dendermonde, 9200

  • Study site

    Edegem, 2650

  • Study site

    Genk, 3600

  • Study site

    Ghent, 9000

  • Study site

    Halen, 3545

  • Study site

    Liège, 4000

  • Study site

    Mechelen, 2800

  • Study site

    Merksem, 2170

  • Study site

    Mons, 7000

  • Study site

    Tienen, 3300

  • Study site

    Turnhout, 2300

  • Study site

    Wetteren, 9230

  • Study site

    Yvoir, 5530

Other trials in Belgium

New Zealand15 sites

  • Study site

    Auckland, 0600

  • Study site

    Auckland, 0620

  • Study site

    Auckland, 0626

  • Study site

    Auckland, 1010

  • Study site

    Christchurch, 8011

  • Study site

    Christchurch, 8024

  • Study site

    Grafton, 1023

  • Study site

    Hamilton, 3200

  • Study site

    Hastings, 4120

  • Study site

    New Plymouth, 4342

  • Study site

    Papamoa, 3118

  • Study site

    Rotorua, 3010

  • Study site

    Tauranga, 3110

  • Study site

    Tauranga, 3144

  • Study site

    Wellington, 6021

Other trials in New Zealand

Spain14 sites

  • Study site

    A Coruña, 15006

  • Study site

    Almería, 04120

  • Study site

    Barcelona, 08003

  • Study site

    Barcelona, 08023

  • Study site

    Barcelona, 08025

  • Study site

    Barcelona, 08034

  • Study site

    Girona, 17005

  • Study site

    Madrid, 28007

  • Study site

    Madrid, 28034

  • Study site

    Málaga, 29010

  • Study site

    Santiago de Compostela, La Coruña, 15706

  • Study site

    Seville, 41003

  • Study site

    Seville, 41010

  • Study site

    Seville, 41071

Other trials in Spain

Croatia13 sites

  • Study site

    Čakovec, 40000

  • Study site

    Dubrovnik, 20000

  • Study site

    Koprivnica, 48000

  • Study site

    Krapinske Toplice, 49217

  • Study site

    Opatija, 51410

  • Study site

    Osijek, 31000

  • Study site

    Rijeka, 51000

  • Study site

    Slavonski Brod, 35000

  • Study site

    Varaždin, 42000

  • Study site

    Virovitica, 33000

  • Study site

    Zabok, 49210

  • Study site

    Zadar, 23000

  • Study site

    Zagreb, 10000

Other trials in Croatia

Denmark12 sites

  • Study site

    Aalborg, 9000

  • Study site

    Aalborg, 9100

  • Study site

    Århus N, 8200

  • Study site

    Ballerup Municipality, 2750

  • Study site

    Copenhagen NV, 2400

  • Study site

    Esbjerg, 6700

  • Study site

    Glostrup Municipality, 2600

  • Study site

    Hellerup, 2900

  • Study site

    Holbæk, 4300

  • Study site

    Nykøbing Falster, 4800

  • Study site

    Vejle, 7100

  • Study site

    Viborg, 8800

Other trials in Denmark

Turkey (Türkiye)12 sites

  • Study site

    Adana, 01330

  • Study site

    Ankara, 06500

  • Study site

    Antalya, 07059

  • Study site

    Edirne, 22030

  • Study site

    Eskişehir, 26480

  • Study site

    Istanbul, 34394

  • Study site

    Istanbul, 34846

  • Study site

    Istanbul, 34890

  • Study site

    Izmir, 35100

  • Study site

    Kocaeli, 41380

  • Study site

    Mersin, 33343

  • Study site

    Sivas, 58140

Other trials in Turkey (Türkiye)

Austria11 sites

  • Study site

    Feldkirch, 6807

  • Study site

    Graz, 8036

  • Study site

    Innsbruck, 6020

  • Study site

    Linz, 4020

  • Study site

    Linz, 4021

  • Study site

    Vienna, 1030

  • Study site

    Vienna, 1060

  • Study site

    Vienna, 1090

  • Study site

    Vienna, 1130

  • Study site

    Vienna, 1170

  • Study site

    Wiener Neustadt, 2700

Other trials in Austria

Lithuania11 sites

  • Study site

    Alytus, 62386

  • Study site

    Kaunas, 47144

  • Study site

    Kaunas, 48259

  • Study site

    Kaunas, 49387

  • Study site

    Kaunas, 49449

  • Study site

    Kaunas, LT-44001

  • Study site

    Kaunas, LT-50161

  • Study site

    Klaipėda, 91131

  • Study site

    Šiauliai, 76231

  • Study site

    Vilnius, 10323

  • Study site

    Vilnius, LT-08661

Other trials in Lithuania

Serbia11 sites

  • Study site

    Belgrade, 11000

  • Study site

    Belgrade, 11040

  • Study site

    Belgrade, 11080

  • Study site

    Kragujevac, 34000

  • Study site

    Niš, 18000

  • Study site

    Pančevo, 26000

  • Study site

    Smederevo, 11300

  • Study site

    Sremska Mitrovica, 22000

  • Study site

    Užice, 31000

  • Study site

    Valjevo, 14000

  • Study site

    Zaječar, 19000

Other trials in Serbia

Chile9 sites

  • Study site

    San Bernardo, 8071064

  • Study site

    Santiago, 00000

  • Study site

    Santiago, 7500000

  • Study site

    Santiago, 7500739

  • Study site

    Santiago, 8150000

  • Study site

    Santiago, 8331143

  • Study site

    Santiago, 8910131

  • Study site

    Temuco, 4781156

  • Study site

    Viña del Mar, 2520997

Other trials in Chile

Latvia9 sites

  • Study site

    Daugavpils, LV-5401

  • Study site

    Kuldīga, LV-3301

  • Study site

    Ogre, LV-5001

  • Study site

    Riga, LV-1010

  • Study site

    Riga, LV-1038

  • Study site

    Riga, LV1002

  • Study site

    Riga, LV1012

  • Study site

    Tukums, LV-3101

  • Study site

    Ventspils, LV-3601

Other trials in Latvia

Estonia4 sites

  • Study site

    Tallinn, 10117

  • Study site

    Tallinn, 10128

  • Study site

    Tallinn, 10138

  • Study site

    Tallinn, 13419

Other trials in Estonia

About this study

Official title: A Randomized, Double-blind, Placebo-controlled Study to Assess the Effects of Bempedoic Acid (ETC-1002) on the Occurrence of Major Cardiovascular Events in Patients With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant

The purpose of this study is to determine if treatment with bempedoic acid (ETC-1002) versus placebo decreases the risk of cardiovascular events in participants who have or are at high risk for cardiovascular disease and are statin intolerant.

Being tested
Bempedoic acid 180 mg tablet, Matching placebo tablet
Medical subject headings
Cardiovascular Diseases

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Bempedoic acid 180 mg tabletDrug

    Also called ETC-1002

    Patients take bempedoic acid 180 mg tablet orally once daily

  • Matching placebo tabletDrug

    Also called placebo comparator

    Patients take matching placebo tablet orally once daily

Study groups in NCT02993406
Study groupRoleWhat they receive
Bempedoic Acid 180 mgExperimentalBempedoic acid 180 mg tablet taken orally, once daily.
Receives: Drug: Bempedoic acid 180 mg tablet
Placebo ComparatorPlacebo comparatorMatching placebo tablet taken orally, once daily
Receives: Drug: Matching placebo tablet

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Number of Participants With First Occurrence of Four Component Major Adverse Cardiovascular Events (MACE)

    The primary efficacy end point was a four-component composite of adjudicated MACE, defined as death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or coronary revascularization, as assessed in a time-to first-event analysis.

    Measured: Up to 68 months

Secondary outcomes (6)

  1. Number of Participants With First Occurrence of Three Component MACE

    The first key secondary end point was a three-component MACE, defined as death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke.

    Measured: Up to 68 months

  2. Number of Participants With First Occurrence of Myocardial Infarction

    Number of participants with time to first occurrence of fatal and non-fatal myocardial infarction are presented.

    Measured: Up to 68 months

  3. Number of Participants With Time to First Occurrence of Coronary Revascularization

    Number of participants with time to first occurrence of coronary revascularization are presented.

    Measured: Up to 68 months

  4. Number of Participants With Time to First Occurrence of Stroke

    Number of participants with time to first occurrence of fatal and non-fatal stroke.

    Measured: Up to 68 months

  5. Number of Participants With Time to Cardiovascular Death

    Number of participants with time to cardiovascular death are presented.

    Measured: Up to 68 months

  6. Number of Participants With Time to All-cause Mortality

    All-cause mortality is death due to any cause. Number of participants with time to all-cause mortality are presented.

    Measured: Up to 68 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted15 Dec 2016 (estimated)
  2. Study start22 Dec 2016
  3. Primary completion7 Nov 2022
  4. Study completion7 Nov 2022

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Triple blind
Who is masked
Participant, Investigator, Outcomes assessor
Enrolment
13,970 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT02993406
Sponsor's protocol ID
1002-043
Acronym
CLEAR Outcomes
Status last verified
Dec 2023
First submitted
9 Dec 2016
Last updated
3 Jan 2024
Data monitoring committee
Yes
Individual data sharing
No

Publications

  • Pinkosky SL, Newton RS, Day EA, Ford RJ, Lhotak S, Austin RC, Birch CM, Smith BK, Filippov S, Groot PHE, Steinberg GR, Lalwani ND. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nat Commun. 2016 Nov 28;7:13457. doi: 10.1038/ncomms13457.

    PubMed 27892461

  • Bilen O, Ballantyne CM. Bempedoic Acid (ETC-1002): an Investigational Inhibitor of ATP Citrate Lyase. Curr Atheroscler Rep. 2016 Oct;18(10):61. doi: 10.1007/s11883-016-0611-4.

    PubMed 27663902

  • Thompson PD, MacDougall DE, Newton RS, Margulies JR, Hanselman JC, Orloff DG, McKenney JM, Ballantyne CM. Treatment with ETC-1002 alone and in combination with ezetimibe lowers LDL cholesterol in hypercholesterolemic patients with or without statin intolerance. J Clin Lipidol. 2016 May-Jun;10(3):556-67. doi: 10.1016/j.jacl.2015.12.025. Epub 2016 Jan 6.

    PubMed 27206943

  • Thompson PD, Rubino J, Janik MJ, MacDougall DE, McBride SJ, Margulies JR, Newton RS. Use of ETC-1002 to treat hypercholesterolemia in patients with statin intolerance. J Clin Lipidol. 2015 May-Jun;9(3):295-304. doi: 10.1016/j.jacl.2015.03.003. Epub 2015 Mar 19.

    PubMed 26073387

  • Nicholls S, Lincoff AM, Bays HE, Cho L, Grobbee DE, Kastelein JJ, Libby P, Moriarty PM, Plutzky J, Ray KK, Thompson PD, Sasiela W, Mason D, McCluskey J, Davey D, Wolski K, Nissen SE. Rationale and design of the CLEAR-outcomes trial: Evaluating the effect of bempedoic acid on cardiovascular events in patients with statin intolerance. Am Heart J. 2021 May;235:104-112. doi: 10.1016/j.ahj.2020.10.060. Epub 2020 Oct 24.

    PubMed 33470195

  • Nissen SE, Lincoff AM, Brennan D, Ray KK, Mason D, Kastelein JJP, Thompson PD, Libby P, Cho L, Plutzky J, Bays HE, Moriarty PM, Menon V, Grobbee DE, Louie MJ, Chen CF, Li N, Bloedon L, Robinson P, Horner M, Sasiela WJ, McCluskey J, Davey D, Fajardo-Campos P, Petrovic P, Fedacko J, Zmuda W, Lukyanov Y, Nicholls SJ; CLEAR Outcomes Investigators. Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. N Engl J Med. 2023 Apr 13;388(15):1353-1364. doi: 10.1056/NEJMoa2215024. Epub 2023 Mar 4.

    PubMed 36876740

  • Nissen SE, Menon V, Nicholls SJ, Brennan D, Laffin L, Ridker P, Ray KK, Mason D, Kastelein JJP, Cho L, Libby P, Li N, Foody J, Louie MJ, Lincoff AM. Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients. JAMA. 2023 Jul 11;330(2):131-140. doi: 10.1001/jama.2023.9696.

    PubMed 37354546

  • Spiazzi BF, Brennan D, Zingano CP, Powell HA, Nicholls SJ, Nissen SE, Laffin LJ. Bempedoic Acid and Venous Thromboembolism Risk Among Statin-Intolerant Patients: A Post Hoc Analysis of the CLEAR Outcomes Randomized Clinical Trial. JAMA Cardiol. 2026 Jul 1;11(7):659-663. doi: 10.1001/jamacardio.2026.1208.

    PubMed 42201706

  • Naderi S, Brennan D, Li N, Lincoff AM, Nicholls SJ, Nissen SE, Plutzky J, Powell HA, Robinson P, Cho L. Sex Differences in Statin Intolerance: Insights From the CLEAR Outcomes Trial. Clin Cardiol. 2026 Apr;49(4):e70288. doi: 10.1002/clc.70288.

    PubMed 41923439

  • Menon V, Bloedon L, Li N, Lincoff AM, Nicholls SJ, Powell HA, Nissen SE. Lack of impact of adjunctive lipid-modifying therapy in the CLEAR Outcomes trial. J Clin Lipidol. 2026 Jan;20(1):196-199. doi: 10.1016/j.jacl.2025.10.072. Epub 2025 Nov 4.

    PubMed 41391972

  • Nicholls SJ, Ray KK, Lincoff AM, Sarnes E, Gillard KK, Bloedon L, Migliaccio-Walle K, Elsea D, Nissen SE. Cost-Effectiveness of Bempedoic Acid in High Cardiovascular Risk Patients with Statin Intolerance: An Analysis of the CLEAR Outcomes Trial. Am J Cardiovasc Drugs. 2026 Jan;26(1):59-70. doi: 10.1007/s40256-025-00753-w. Epub 2025 Aug 20.

    PubMed 40833562

  • Laufs U, Lincoff AM, Nicholls SJ, Li N, Bloedon L, Sasiela WJ, Powell HA, Herout PM, Thompson PD, Nissen SE. Characteristics and outcomes of patients with and without statin-associated muscle symptoms treated with bempedoic acid in the CLEAR Outcomes trial. J Clin Lipidol. 2025 Mar-Apr;19(2):337-347. doi: 10.1016/j.jacl.2024.12.014. Epub 2024 Dec 25.

    PubMed 39939212

  • Bays HE, Bloedon L, Brennan D, Lei L, Lincoff AM, Nicholls SJ, Plutzky J, Powell HA, Nissen SE. Bempedoic Acid for Prevention of Cardiovascular Events in People With Obesity: A CLEAR Outcomes Subset Analysis. J Am Heart Assoc. 2025 Feb 18;14(4):e037898. doi: 10.1161/JAHA.124.037898. Epub 2025 Feb 8.

    PubMed 39921511

  • Lincoff AM, Ray KK, Sasiela WJ, Haddad T, Nicholls SJ, Li N, Cho L, Mason D, Libby P, Goodman SG, Nissen SE. Comparative Cardiovascular Benefits of Bempedoic Acid and Statin Drugs. J Am Coll Cardiol. 2024 Jul 9;84(2):152-162. doi: 10.1016/j.jacc.2024.04.048.

    PubMed 38960508

  • Ray KK, Nicholls SJ, Li N, Louie MJ, Brennan D, Lincoff AM, Nissen SE; CLEAR OUTCOMES Committees and Investigators. Efficacy and safety of bempedoic acid among patients with and without diabetes: prespecified analysis of the CLEAR Outcomes randomised trial. Lancet Diabetes Endocrinol. 2024 Jan;12(1):19-28. doi: 10.1016/S2213-8587(23)00316-9. Epub 2023 Dec 4.

    PubMed 38061370

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Bempedoic acid 180 mg tablet in people with Cardiovascular Diseases and Statin Adverse Reaction, run by Esperion Therapeutics, Inc. at 1,319 sites in 32 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 9 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 3 Jan 2024. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1,319 sites in United States, Brazil, Poland, Argentina, Russia and 27 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

Yes. Results are posted in the registry (first posted 3 Jan 2024). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Number of Participants With First Occurrence of Four Component Major Adverse Cardiovascular Events (MACE) (time frame: Up to 68 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT02993406, which also lists 16 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jan 2024.

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