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Rhinitis, AllergicNCT02866864

Animal Allergy in Korean Veterinary Researcher

An observational study of Rhinitis, Allergic and Asthma, run by Gachon University Gil Medical Center at 1 site in South Korea.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The investigators will evaluate sensitization to animal allergens and allergic symptom during contacting animal allergens in Korean veterinary researchers who attend their annual conference. Read more about this study

Who is it for?
Ages 19 years and olderHealthy volunteers can take part
Conditions the study is for
Rhinitis, Allergic, Asthma, Dermatitis, Atopic
What is being tested?
Animal allergy + and Animal allergy -
How many people
135 participants
Where
1 siteSouth Korea
Study dates
24 Aug 2016to 1 Sep 2016
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 19 years and older
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Study population: Korean Veterinary Researcher

Who may be able to join

  • Veterinary researchers attending their annual conference

Who cannot join

  • Veterinary researchers who receive medication including antihistamine (H1 and H2 blocker), systemic glucocorticosteroid which can effect on the result of skin prick test
  • Veterinary researchers who do not want to participate in this study

Trial locations and contacts

1 site in 1 country.

South Korea1 site

  • Gachon University Gil Medical Center

    Incheon, 405-760

Other trials in South Korea

About this study

Official title: Sensitization to Animal Allergens and Allergic Symptoms During Exposure to Animal Allergens in Korean Veterinary Researcher

The investigators will evaluate sensitization to animal allergens and allergic symptom during contacting animal allergens in Korean veterinary researchers who attend their annual conference.

The investigators will compare sensitization to animal allergen and other clinical and occupational factors between subjects who suffer from allergic symptom during contacting animal and those who do not.

Read the detailed description

The investigators will visit annual conference of Korean veterinary researchers.

After informed consent, Korean veterinary researchers who attend their conference and agree to enrollment into this study will be asked to respond to questionnaires regarding their gender, age, underlying allergic diseases, family history of allergic diseases, occupation and it's duration, contact animal and contact duration. Subjects will also be requested to report allergic symptom, causal animal and situation of contact including veterinary service, animal experiment, pet ownership, and ingestion if subjects suffer from allergic symptom when subjects contact animal.

Then, subjects will also be asked to undergo skin prick test for animal allergens including chicken feather and ten mammal epithelia as well as cow's milk, and hen's egg, four fish flesh and seven animal meats.

subjects will be divided into two group, subjects who suffer from allergic symptom during contacting animal and those who do not. Between two groups, sensitization to animal allergens as well as other demographic and occupational factors including gender, age, underlying allergic diseases, family history of allergic diseases, occupation and it's duration, contact animal and contact duration will be compared.

Being tested
Animal allergy +, Animal allergy -
Keywords
Allergen, Veterinary, Allergy, Animals
Medical subject headings
Rhinitis, Allergic, Asthma, Dermatitis, Atopic, Urticaria, Hypersensitivity

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Animal allergy +Other

    Allergic symptom occurs when subject contact animal

  • Animal allergy -Other

    Allergic symptom does not occur when subject contact animal

Study groups in NCT02866864
Study groupRoleWhat they receive
Subjects with animal allergySubjects who suffer from allergic symptom during contact with animal
Receives: Other: Animal allergy +
Subjects without animal allergySubjects who do not suffer from allergic symptom during contact with animal
Receives: Other: Animal allergy -

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Skin reactivity to animal allergen in skin prick test

    Mean diameter of wheal for animal allergen in skin prick test

    Measured: on the day of survey (day 1)

Secondary outcomes (9)

  1. Underlying allergic disease

    Underlying allergic disease including allergic rhinitis, asthma, atopic dermatitis, urticaria, food and drug allergy

    Measured: on the day of survey (day 1)

  2. Family history of allergic disease

    Family history of allergic disease including allergic rhinitis, asthma, atopic dermatitis, urticaria, food and drug allergy

    Measured: on the day of survey (day 1)

  3. Occupation

    Type of occupation including veterinary service and veterinary experiment

    Measured: on the day of survey (day 1)

  4. Duration of occupation

    Duration of occupation (year)

    Measured: on the day of survey (day 1)

  5. Contact animal

    Kinds of animals that subjects contact

    Measured: on the day of survey (day 1)

  6. Contact time

    Duration of animal contact (hour/day)

    Measured: on the day of survey (day 1)

  7. Causal animal

    Animal that provokes allergic symptom when subject contact it

    Measured: on the day of survey (day 1)

  8. Contact situation

    Situation including veterinary service, veterinary research, ingestion and pet ownership in which subject contact animal that provokes allergic symptom

    Measured: on the day of survey (day 1)

  9. Allergic symptom during contacting animal

    Allergic symptom including itchy eyes, nose and skin, rhinorrhea, sneezing, nasal congestion, postnasal drip, dyspnea, wheezing, cough, sputum, chest pain or discomfort, urticaria, rash, and angioedema when subject contact animal

    Measured: on the day of survey (day 1)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted15 Aug 2016 (estimated)
  2. Study start24 Aug 2016
  3. Primary completion26 Aug 2016
  4. Study completion1 Sep 2016

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Ecologic or community
Time perspective
Cross-sectional
Enrolment
135 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT02866864
Sponsor's protocol ID
GachonUGilMC
Status last verified
Mar 2017
First submitted
31 Jul 2016
Last updated
3 Mar 2017
Results posted
No
Data monitoring committee
Yes
Individual data sharing
No: Individual participant will be informed of results of questionnaires and skin prick test immediately after they complete questionnaires and skin prick test

Publications

  • Blair A, Hayes HM Jr. Cancer and other causes of death among U.S. veterinarians, 1966-1977. Int J Cancer. 1980 Feb 15;25(2):181-5. doi: 10.1002/ijc.2910250203.

    PubMed 7390647

  • Elbers AR, Blaauw PJ, de Vries M, van Gulick PJ, Smithuis OL, Gerrits RP, Tielen MJ. Veterinary practice and occupational health. An epidemiological study of several professional groups of Dutch veterinarians. I. General physical examination and prevalence of allergy, lung function disorders, and bronchial hyperreactivity. Vet Q. 1996 Dec;18(4):127-31. doi: 10.1080/01652176.1996.9694711.

    PubMed 8972059

  • Samadi S, Spithoven J, Jamshidifard AR, Berends BR, Lipman L, Heederik DJ, Wouters IM. Allergy among veterinary medicine students in The Netherlands. Occup Environ Med. 2012 Jan;69(1):48-55. doi: 10.1136/oem.2010.064089. Epub 2011 May 31.

    PubMed 21632519

  • Park YB, Mo EK, Lee JY, Kim JH, Kim CH, Hyun IG, Choi JH. Association between pet ownership and the sensitization to pet allergens in adults with various allergic diseases. Allergy Asthma Immunol Res. 2013 Sep;5(5):295-300. doi: 10.4168/aair.2013.5.5.295. Epub 2013 Jun 25.

    PubMed 24003386

  • Moghtaderi M, Farjadian S, Abbaszadeh Hasiri M. Animal allergen sensitization in veterinarians and laboratory animal workers. Occup Med (Lond). 2014 Oct;64(7):516-20. doi: 10.1093/occmed/kqu097. Epub 2014 Aug 7.

    PubMed 25104279

  • Lutsky I, Baum GL, Teichtahl H, Mazar A, Aizer F, Bar-Sela S. Occupational respiratory disease in veterinarians. Ann Allergy. 1985 Aug;55(2):153-6.

    PubMed 4025958

  • Susitaival P, Kirk JH, Schenker MB. Atopic symptoms among California veterinarians. Am J Ind Med. 2003 Aug;44(2):166-71. doi: 10.1002/ajim.10253.

    PubMed 12874849

  • Krakowiak A, Wiszniewska M, Krawczyk P, Szulc B, Wittczak T, Walusiak J, Palczynski C. Risk factors associated with airway allergic diseases from exposure to laboratory animal allergens among veterinarians. Int Arch Occup Environ Health. 2007 May;80(6):465-75. doi: 10.1007/s00420-006-0153-0. Epub 2006 Oct 5.

    PubMed 17021840

  • Will LA, Nassif EG, Engen RL, Patterson RA, Zimmerman D. Allergy and pulmonary impairment in Iowa veterinarians. N Engl Reg Allergy Proc. 1987 May-Jun;8(3):173-7. doi: 10.2500/108854187778984645.

    PubMed 3477686

  • Samadi S, Wouters IM, Heederik DJ. A review of bio-aerosol exposures and associated health effects in veterinary practice. Ann Agric Environ Med. 2013;20(2):206-21.

    PubMed 23772565

Questions about this trial

What is this clinical trial studying?

An observational study of Rhinitis, Allergic and Asthma, run by Gachon University Gil Medical Center at 1 site in South Korea.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 3 Mar 2017. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in South Korea. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Skin reactivity to animal allergen in skin prick test (time frame: on the day of survey (day 1)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT02866864, which also lists 10 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Mar 2017.

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