Rheumatic Joint DiseaseNCT02418442
Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
An observational study of Rheumatic Joint Disease, run by Duke University at 82 sites in 5 countries.
Trial summary
Continuation of the CARRA Registry as described in the protocol will support data collection on patients with pediatric-onset rheumatic diseases. The CARRA Registry will form the basis for future CARRA studies. Read more about this study
- Who is it for?
- Ages Up to 21 years
- Conditions the study is for
- Rheumatic Joint Disease
- How many people
- 20,000 participants
- Where
- 82 sitesin 5 countries
- Study dates
- Jul 2015to Dec 2028
- How long will I take part?
- 10 Years
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Up to 21 years
- All sexes
- No healthy volunteers
- Child, Adult
Study population: Children with pediatric rheumatic diseases enrolled from participating CARRA sites.
Who may be able to join
- Onset of rheumatic disease prior to age 16 years for JIA and onset prior to age 19 years for all other rheumatic diseases (see appendix A).
- Subject (and/or parent/legal guardian when required) is able to provide written informed consent and willing to comply with study procedures.
- Subject and/or parent/legal guardian is willing to be contacted in the future by study staff.
Who cannot join
- 1. Greater than 21 years of age at the time of enrollment.
Trial locations and contacts
82 sites in 5 countries. Contact the study team or a site near you to ask about taking part.
82 sites in 5 countries
United States75 sites, 66 recruiting
- Recruiting
Akron Children's Hospital
Akron, Ohio, 44308
Jessica Kracker, jkracker@akronchildrens.org
Kate Cook, DO
- Recruiting
Albany Medical College
Albany, New York, 122089
Suhas Ganguli, 518-262-6682, GangulS@amc.edu
Suhas Ganguli
- Recruiting
University of Michigan
Ann Arbor, Michigan, 48109
Jack Shemke, shemkeja@med.umich.edu
Smriti Mohan, MD
- Recruiting
Emory Children's Center
Atlanta, Georgia, 30322
Lori Ponder, 404-727-3583, laponde@emory.edu
Sampath Prahalad, MD
- Recruiting
Georgia Regents University Medical Center
Augusta, Georgia, 30912
Heidi Stapp, 706-721-7699, hstapp@augusta.edu
Julisa Patel, MD
- Recruiting
The Children's Hospital of Colorado
Aurora, Colorado, 80045
Ana Aristiguieta, Ana.Aristiguieta@childrenscolorado.org
Katharine Moore, MD
- Recruiting
University of Alabama at Birmingham
Birmingham, Alabama, 35233
Livie Timmerman, 205-625-9140, liviet09@uab.edu
Melissa Mannion, MD
- Recruiting
Tufts Medical Center
Boston, Massachusetts, 02111
Kiran Singh, 617-636-9197, Kiran.Singh@tuftsmedicine.org
Trevor Davis, MD
- Recruiting
Massachusetts General Hospital for Children
Boston, Massachusetts, 02114
Marc Natter, 617-726-2730, mnatter@mgh.harvard.edu
Marc Natter, MD
- Recruiting
Boston Children's Hospital
Boston, Massachusetts, 02115
Kyle McBrearty, Kyle.McBrearty@childrens.harvard.edu
Joyce Chang, MD
- Recruiting
University of Vermont Medical Center
Burlington, Vermont, 05401
Sage Hannon, barbara.hannon@med.uvm.edu
Matthew Hollander, MD
- Recruiting
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599
Carolina Pastrana-Medina, 919-564-5220, carol825@med.unc.edu
Eveline Wu, MD
- Recruiting
Medical University of South Carolina Children's Hospital
Charleston, South Carolina, 29425
Susannah Wakefield, 843-792-8317, wakefies@musc.edu
Natasha Ruth, MD
- Recruiting
Levine Children's Hospital / Carolinas Medical Center
Charlotte, North Carolina, 28203
Crystal Reed, 704-770-6258, crystal.reed@advocatehealth.org
Thomas Griffin, MD
- Withdrawn
University of Illinois at Chicago
Chicago, Illinois, 60607
- Recruiting
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60614
Tyler Sorenson, 312-227-6276, tsorensen@luriechildrens.org
Marisa Klein-Gitelman, MD
- Recruiting
University of Chicago Medical Center
Chicago, Illinois, 60637
Sydni Hill, Sydni.Hill@bsd.uchicago.edu
Melissa Tesher, MD
- Recruiting
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229
Megan Quinlan-Waters, 513-636-3644, Megan.Quinlan-Waters@cchmc.org
Sheila Angeles-Han, MD
- Terminated
UH Rainbox Babies and Children's Hospital
Cleveland, Ohio, 44106
- Recruiting
Metrohealth Medical Center
Cleveland, Ohio, 44109
Rozina Aamir, 216-778-2628, raamir@metrohealth.org
Hulya Bukulmez, MD
- Recruiting
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
Brittany Randall, 216-445-6405, RANDALB6@ccf.org
Angela Robinson, MD
- Recruiting
Nationwide Children's Hospital
Columbus, Ohio, 43205
Rania Badran, 614-722-0741, Rania.Badran@nationwidechildrens.org
Stacy Ardoin, MD
- Recruiting
University of Texas Southwestern Medical Center Dallas
Dallas, Texas, 75219
Lenice Franklin, 214-559-8531, lenice.franklin@tsrh.org
Elizabeth Sloan, MD
- Recruiting
Duke Children's Hospital & Health Center
Durham, North Carolina, 27710
Lynn Rodgers, 919-668-2953, lynn.rodgers@duke.edu
Heather Van Mater, MD
- Recruiting
Sanford Health
Fargo, North Dakota, 58122
Josie Schahn, 701-234-3722, Josephine.Schahn@SanfordHealth.org
Grant Syverson, MD
- Recruiting
University of Florida - Shand's Children's Hospital
Gainesville, Florida, 32608
Melissa Lingis, 352-294-8556, Melissa.Lingis@peds.ufl.edu
Leandra Woolnough, MD
- Recruiting
Helen Devos Children's Hospital
Grand Rapids, Michigan, 49503
Genesis Pablo Mendoza, 616-391-1783, Genesis.PabloMendoza@corewellhealth.org
Cory Stingl, MD
- Terminated
West Michigan Rheumatology
Grand Rapids, Michigan, 49546
- Recruiting
Hackensack University Medical Center
Hackensack, New Jersey, 07601
Amanda Rodowicz, 551-996-3114, amanda.rodowicz@hmhn.org
Jennifer Weiss, MD
- Recruiting
Connecticut Children's Medical Center
Hartford, Connecticut, 06106
Jennifer Twachtman-Bassett, Jtwachtman@connecticutchildrens.org
Barbara Edelheit, MD
- Recruiting
Penn State Children's Hospital
Hershey, Pennsylvania, 17033
Meredith Buckley, 717-531-0003 ext. 286546, mbuckley@pennstatehealth.psu.edu
Timothy Hahn, MD
- Recruiting
Baylor College of Medicine Pediatric Immunology Allergy Rheumatology
Houston, Texas, 77030
Monica Guevara, 832-824-1206, Monica.Guevara@bcm.edu
Marietta DeGuzman, MD
- Recruiting
Indiana University School of Medicine
Indianapolis, Indiana, 46202
Elly Duncan, emckinse@iu.edu
Stacey Tarvin, MD
- Recruiting
The University of Iowa Hospitals and Clinics (University of Iowa Children's Hospital)
Iowa City, Iowa, 52242
Joehan Quach, 402-237-9936, joehan-quach@uiowa.edu
Sandy Hong, MD
- Recruiting
University of Mississippi Medical Center
Jackson, Mississippi, 39216
Kaylee Rhodes, kdrhodes@umc.edu
Yasmin Elzaki, MD
- Terminated
University of Kansas Medical Center
Kansas City, Kansas, 66160
- Recruiting
Children's Mercy Hospital
Kansas City, Missouri, 64108
Ashley Lytch, 816-855-1957, amlytch@cmh.edu
Ashley Cooper, MD
- Recruiting
Cohen Children's Medical Center of New York
Lake Success, New York, 11042
Ashley Machado, 516-472-3711, amachado3@northwell.edu
Heather Walters, MD
- Not yet recruiting
Children's Hospital of Los Angeles
Los Angeles, California, 90027
Ana Cancino, 323-361-5958, ancabrera@chla.usc.edu
Katherine Marzan, MD
- Recruiting
Mattel Children's Hospital at University of California Los Angeles
Los Angeles, California, 90095
Alexis Stephens, 310-825-7257, AVStephens@mednet.ucla.edu
Deborah McCurdy, MD
- Recruiting
University of Louisville Schoole of Medicine
Louisville, Kentucky, 40202
Kristin Klein, 502-588-4911, kristin.klein@louisville.edu
Alexis Begezda, MD
- Recruiting
University of Wisconsin, American Family Children's Hospital
Madison, Wisconsin, 53792
Susy Cranley, 608-264-2200, cranley2@wisc.edu
Dominic Co, MD, PhD
- Terminated
Nicklaus Children's Hospital
Miami, Florida, 33155
- Recruiting
University of Minnesota
Minneapolis, Minnesota, 55454
Ellen Bruno, 612-301-1554, bruno033@umn.edu
Colleen Correll, MD
- Recruiting
Goryeb Children's Hospital
Morristown, New Jersey, 07960
Marie Fox, 973-971-6308, marie.fox@atlantichealth.org
Simona Nativ, MD
- Recruiting
Monroe Carrell Jr. Children's Hospital at Vanderbilt
Nashville, Tennessee, 37232
Brooke Fine, 615-322-4397, brooke.fine@vumc.org
Thomas Graham, MD
- Recruiting
Robert Wood Johnson Medical School
New Brunswick, New Jersey, 08901
Christina Varghese, 732-235-7570, chrisvar@rwjms.rutgers.edu
Nandini Moorthy, MD
- Terminated
Yale University
New Haven, Connecticut, 06519
- Terminated
New York University Langone Medical Center
New York, New York, 10016
- Recruiting
Hospital for Special Surgery
New York, New York, 10021
Julia Klauss, 212-774-2703, klaussj@HSS.EDU
Karen Onel, MD
- Recruiting
Columbia University Medical Center
New York, New York, 10032
Marcela Arizabaleta, 212-342-2751, ma5005@cumc.columbia.edu
Lisa Imundo, MD
- Recruiting
Children's Hospital at Montefiore
New York, New York, 10467
Emily "Mimi" Gillies, egillies@montefiore.org
Dawn Wahezi, MD
- Recruiting
Children's Hospital of the King's Daughters
Norfolk, Virginia, 23507
Cassy Todd, 757-668-7176, Cassandra.Todd@CHKD.ORG
Cassyanne Aguiar, MD
- Recruiting
Nemours Children's Hospital
Orlando, Florida, 32827
Micah Reisner, 407-567-6206, Micah.Reisner@nemours.org
Mary Toth, MD
- Recruiting
Stanford University Medical Center
Palo Alto, California, 94304
Aihua Zhu, 650-384-5917, azhu1@stanford.edu
Joyce Hsu, MD
- Recruiting
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104
Griffin Stein, 267-426-8726, steing2@chop.edu
Pamela Weiss, MD
- Recruiting
Saint Christopher's Hospital for Children
Philadelphia, Pennsylvania, 19134
Kimberly Nocella, 215-427-8460, Kimberly.Nocella@towerhealth.org
Dana Toib, MD
- Recruiting
Phoenix Children's Hospital
Phoenix, Arizona, 85254
Sabrina Gorry, 602-933-3822, sgorry@phoenixchildrens.com
Kaleo Ede, MD
- Recruiting
Children's Hospital of Pittsburgh UPMC
Pittsburgh, Pennsylvania, 15224
Reagan Devine, 412-692-7567, deviner3@upmc.edu
Margalit Rosenkranz, MD
- Recruiting
Randall Children's Hospital at Legacy Emanuel
Portland, Oregon, 97227
Brenna Bogle, 503-413-3930, BBOGLE@LHS.ORG
Daniel Kingsbury, MD
- Recruiting
Hasbro Children's Hospital
Providence, Rhode Island, 02903
Morgan Barnes, 401-444-5543, MBarnes3@brownhealth.org
Ali Yalcindag, MD
- Recruiting
Mayo Clinic
Rochester, Minnesota, 55905
Jennifer Kramer, 507-293-9555, Kramer.Jennifer2@mayo.edu
Matthew Basiaga, DO
- Recruiting
University of Rochester
Rochester, New York, 14642
Jill Cross, 585-275-8991, Jill_Cross@URMC.Rochester.edu
Christina Schutt, DO
- Recruiting
University of Utah Hospitals and Clinics (Primary Children's Hospital)
Salt Lake City, Utah, 84113
Sarah Wallgren, sarah.wallgren@hsc.utah.edu
Christi Inman, MD
- Recruiting
Rady Children's Hospital San Diego
San Diego, California, 92123
Nairobi Lindsey, 858-966-8082, nlindsey@ucsd.edu
Johanna Chang, MD
- Recruiting
University of California at San Francisco Medical Center
San Francisco, California, 94143
Zilan Zheng, 415-353-1301, Zilan.Zheng@ucsf.edu
Susan Kim, MD
- Recruiting
Seattle Children's Hospital
Seattle, Washington, 98105
Albert Hsu, 206-987-2057, Albert.Hsu@seattlechildrens.org
Kabita Nanda, MD
- Terminated
Bay State Medical Center
Springfield, Massachusetts, 01105
- Terminated
Saint Louis University School of Medicine
St Louis, Missouri, 63104
- Recruiting
Saint Louis Children's Hospital
St Louis, Missouri, 63110
Kristen McDaniels, 314-273-9064, k.mcdaniels@wustl.edu
Kevin Baszis, MD
- Recruiting
Johns Hopkins All Children's Hospital
St. Petersburg, Florida, 33701
Jasmine Niazi, 727-767-6949, jniazi1@jh.edu
Lilliana Barillas-Arias, MD
- Recruiting
Childrens National Medical Center
Washington D.C., District of Columbia, 20010
Katie Dunnock, 202-476-5746, kdunnock@childrensnational.org
Tova Ronis, MD
- Recruiting
Children's Hospital Of Wisconsin
Wauwatosa, Wisconsin, 53226
Erin Hammelev, 412-266-6352, ehammele@mcw.edu
Sara Sabbagh, DO
- Recruiting
The Pediatric Specialty Center at Saint Barnabas
West Orange, New Jersey, 07052
Marilyn Ricca, 973-322-6961, Marilyn.Ricca@rwjbh.org
Elizabeth Chalom, MD
- Recruiting
Wake Forest Baptist Brenner Children's Hospital
Winston-Salem, North Carolina, 27012
Anya Brown, 336-716-5650, Anya.Brown@advocatehealth.org
Onengiya Harry, MD
Canada4 sites, 4 recruiting
- Recruiting
University of Calgary - Alberta Children's Hospital
Calgary, Alberta, AB T38 6A8
Kissan Ghose, 403-955-5537, Kissan.Ghose@albertahealthservices.ca
Marinka Twilt, MD, PhD
- Recruiting
IWK Health Center
Halifax, Nova Scotia, NS B3K 6R8
Abigail Butler, 902-470-7414, Abbie.Butler@iwk.nshealth.ca
Adam Huber, MD
- Recruiting
The Hospital for Sick Children
Toronto, Ontario
Ingrid Goh, 416-813-6372, ingrid.goh@sickkids.ca
Brian Feldman, MD
- Recruiting
University of Manitoba - Children's Hospital of Manitoba
Winnipeg, Manitoba, R3E 3P4
Sabhyam Kafle, 204-789-3888, skafle@chrim.ca
Lily Lim, PhD
Israel1 site
- Terminated
Schneider Children's Medical Center of Israel
Petah Tikva, 49202-35
Italy1 site, 1 recruiting
- Not yet recruiting
IRCCS Ospedale Pediatrico Bambino Gesu (OPBG)
Rome
Denise Pires Marafon, 0039 06 6859 2801, demarafon@yahoo.com
Fabrizio De Benedetti
About this study
Continuation of the CARRA Registry as described in the protocol will support data collection on patients with pediatric-onset rheumatic diseases. The CARRA Registry will form the basis for future CARRA studies. In particular, this observational registry will be used to answer pressing questions about therapeutics used to treat pediatric rheumatic diseases, including safety questions.
Read the detailed description
The original Childhood Arthritis \& Rheumatology Research Alliance (CARRA) Registry (Protocol Number: CRNT_REGST01) was first established in 2010 to advance alliance infrastructure, facilitate expanded clinical and translational pediatric research, and transform the culture of pediatric rheumatology toward universal participation in research. This original CARRA Registry will be referred to throughout the protocol as the CARRA Legacy Registry. Through the creation of a sophisticated informatics infrastructure, provision of comprehensive site support and the engagement of families, patients, and communities, the CARRA Registry will provide the opportunity for affected children at every CARRA Registry site to participate in high-quality clinical and translational research.
Continuation of the CARRA Registry as described in this protocol will support data collection on patients with pediatric-onset rheumatic diseases. The CARRA Registry will form the basis for future CARRA studies. In particular, this observational registry will be used to answer pressing questions about therapeutics used to treat pediatric rheumatic diseases, including examining safety questions. The Duke Clinical Research Institute (DCRI) is serving as the CARRA Clinical and Data Coordinating Center (CDCC) for the protocol.
Traditional exposure-based post-marketing registries of individual therapeutic agents for juvenile idiopathic arthritis (JIA), systemic lupus erythematosus, and other rheumatic diseases are inadequate for answering important safety questions for many reasons:
- Sample sizes are too small to detect uncommon but important events
- No unexposed comparators exist to evaluate risk attributable to underlying disease
- Duration of follow-up of individual patients is too short to evaluate many potential delayed adverse events (AEs)
- Sample sizes are inadequate to assess myriad complex and dynamic concurrent medication regimens common to treatment of rheumatic diseases
- Selective patient enrollment limits evaluation of co-morbid conditions and other patient factors
These limitations prevent patients, families, and providers from understanding the true risks and benefits of therapy in order to make appropriate and informed decisions. They also prevent drug manufacturers and regulatory agencies from conducting an informed review of marketed products for these diseases.
A registry based on disease diagnosis rather than specific therapeutic agents overcomes many of the limitations of exposure-based single-agent registries in the assessment of delayed or uncommon safety events. Indeed, data from a consolidated disease-based registry "...could provide the information necessary for individual companies to satisfy post-marketing requirements and commitments and obviate the need for an individual product registry" (letters from the United States (US) Food and Drug Administration (FDA) to CARRA, 21 December 2010 and 9 December 2011). This protocol details the foundation of a registry to meet these objectives.
The CARRA Registry aims to detect and understand the epidemiology of important AEs, including those that are delayed or uncommon. Subjects followed at active CARRA Registry sites are eligible for enrollment, regardless of past or current treatment. Each subject will be followed prospectively for a goal of 10 years duration; the study will continue indefinitely as resources allow and continued need exists. Data will be systematically collected, including important patient factors, therapies, serious adverse events (SAEs), and protocol-defined events of special interest. Selected safety events (e.g., malignancies) will be adjudicated by a panel of experts via a review of medical records. The CARRA Registry, a disease-based prospective observational registry, enables both detection of potential safety signals and hypothesis-driven, rigorous, and adequately-controlled pharmacoepidemiologic studies of important AEs and their associations with therapeutic agents.
In addition to answering questions about the safety of therapeutics, the data collected in the CARRA Registry are anticipated to serve many other valuable uses. Within the confines of observational study design, the effectiveness of therapeutic agents may be examined for short- and long-term clinical and patient-centered outcomes.
The Registry is the data collection platform for Consensus Treatment Plan (CTP) comparative effectiveness research in pediatric rheumatic disease. Patients enrolled in the Registry may also be eligible to be followed as part of a CTP subset. Examples of CTP projects include:
FiRst line Options for Systemic JIA Treatment (FROST). The purpose of FROST was to compare the effectiveness of CARRA systemic JIA (sJIA) treatment strategies (biologic vs. non-biologic) in achieving clinically inactive disease in patients with new-onset sJIA. Additionally, FROST aimed to compare patient/caregiver reported outcomes between treatment strategies. FROST enrolled new-onset, previously untreated sJIA patients who are starting treatment with one of the 4 sJIA CTPs (glucocorticoid (GC) only; Methotrexate + GC; IL-1 inhibitor + GC; IL-6 + GC). Enrollment will occur over 3 years at all CARRA Registry sites. In addition to routine Registry data collection, patients followed as part of the FROST CTP completed additional questionnaires about their disease status and quality of life.
Medication use for pediatric rheumatic diseases is dynamic and not well characterized. The CARRA Registry represents a powerful data source to follow drug use patterns and provides the opportunity to study predictors of medication use. Important outcomes are likely to be influenced by other factors in addition to therapy (e.g., disease severity) and the CARRA Registry is positioned to help answer these types of questions. Patient-reported outcomes (PROs) generated by patients outside the context of clinical encounters may be collected in the Registry to provide a rich, additional dimension of data to better understand rheumatic diseases. Practitioners may review clinical data from their sites as part of a quality improvement approach to better outcomes.
Analyses of CARRA Registry data aim to provide results to guide the therapeutic decisions made by affected children, families, and providers while improving regulatory efficiency and reducing cost. Ultimately, this approach might serve as a model for successful collaboration between research community networks, industry, and public agencies to promote the effective and efficient evaluation of drugs and devices across the regulatory continuum.
- Conditions
- Rheumatic Joint Disease
- Keywords
- Systemic Arthritis, Oligoarthritis, Polyarthritis (Rheumatoid Factor Negative), Polyarthritis (Rheumatoid Factor Positive), Psoriatic Arthritis, Enthesitis Related Arthritis (ERA), Undifferianted Arthritis, CARRA Consensus Treatment Plans
- Medical subject headings
- Arthritis, Negative rheumatoid factor polyarthritis, Arthritis, Psoriatic, Arthritis, Juvenile
What is being measured
The primary outcome is the main question the study is designed to answer.
Prospectively collect essential data elements from children, adolescents and young adults with pediatric rheumatic diseases
Measured: Approximately 10 years
Evaluate the safety of therapeutic agents in persons with pediatric onset rheumatic diseases
Measured: Approximately 10 years
Secondary outcomes (3)
Evaluate clinical outcomes associated with the use of therapeutic agents in persons with pediatric onset rheumatic diseases
Measured: Approximately 10 years
Document drug treatment patterns and clinical course of persons with pediatric onset rheumatic diseases over time.
Measured: Approximately 10 years
Evaluate factors other than drug treatments that are associated with clinical outcomes in pediatric onset rheumatic diseases
Measured: Approximately 10 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Apr 2015 (estimated)
- Study startJul 2015
- Primary completionJun 2028 (estimated)
- Study completionDec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Rheumatic Joint DiseaseStudies of the same condition, open and under way.
- More trials run by Duke UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 20,000 participants (estimated)
- Target duration
- 10 Years
Sponsor and investigators
- Lead sponsor
- Duke University
- Sponsor type
- University, hospital or other
- Collaborators
- Childhood Arthritis and Rheumatology Research Alliance
- Responsible party
- Sponsor
- Investigators
- Mara L Becker, MD, MSCE, Principal investigator, Duke Clinical Research InsituteMary Beth Son, MD, Principal investigator, Boston Children's HospitalTimothy Beukelman, MD, MSCE, Principal investigator, University of Alabama at Birmingham
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02418442
- Sponsor's protocol ID
- Pro00054616
- Status last verified
- Oct 2026
- First submitted
- 13 Apr 2015
- Last updated
- 21 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
Publications
Nigrovic PA, Beukelman T, Tomlinson G, Feldman BM, Schanberg LE, Kimura Y; Childhood Arthritis and Rheumatology Research Alliance Systemic Juvenile Idiopathic Arthritis Consensus Treatment Plan Workgroup. Bayesian comparative effectiveness study of four consensus treatment plans for initial management of systemic juvenile idiopathic arthritis: FiRst-Line Options for Systemic juvenile idiopathic arthritis Treatment (FROST). Clin Trials. 2018 Jun;15(3):268-277. doi: 10.1177/1740774518761367. Epub 2018 Mar 15.
PubMed 29542334