Episodic MemoryMULTIBRAIN_1NCT02172677
The Influence of Collective Schemas on Individual Memory (MULTIBRAIN_1)
A study testing Episodic memory task and fMRI in people with Episodic Memory, run by Institut National de la Santé Et de la Recherche Médicale, France at 1 site in France.
Trial summary
Schemas describe mental structures storing recurrent and organized pattern of information. Schemas may have a strong influence on the process of storing and retrieving new information into memory. Read more about this study
- Who is it for?
- Ages 20 to 38 yearsHealthy volunteers can take part
- Conditions the study is for
- Episodic Memory
- What is being tested?
- Episodic memory task and fMRI
- Type of treatment
- Medical device, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 27 participants
- Where
- 1 siteFrance
- Study dates
- Oct 2014to 14 Oct 2016
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 38 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy participants between 20 and 38 years old
- Affiliated to the French national health care system
- French native speaker
- Participated in a tour trip at the Memorial of Caen within the last 3 months
- Right-handed
- At least 2 years of education after graduating from high school
- Body mass < 30kg/m2
- Signed written consent form
Who cannot join
- Pregnancy or intent to get pregnant
- Person deprived of their liberty
- Person hospitalized without consent
- Minor
- Protected adults or people unable to give informed consent
- Person subjected to an exclusion period related to another protocol
Show all 13Show fewer
- History of neurological or psychiatric disorders or existence of traumatic brain injury with loss of consciousness for more than one hour
- History of cancer with the last 5 years, excluding squamous cell carcinomas
- Alcoholism, antecedents of chronic alcoholism or drugs abuse
- Severe psychiatric disorders (according to DSM V diagnostic criteria) or psychological troubles which could affect participant's judgment
- Use of medication that may interfere with cognitive or cerebral functioning
- Presence of visual or hearing troubles that may compromise participant's ability to participate in the study
- MRI Contraindications
Trial locations and contacts
1 site in 1 country.
About this study
Official title: ETUDE D'IMAGERIE PAR RESONANCE MAGNETIQUE FONCTIONNELLE CHEZ LE SUJET SAIN DES RELATIONS ENTRE MEMOIRE COLLECTIVE ET INDIVIDUELLE
Schemas describe mental structures storing recurrent and organized pattern of information. Schemas may have a strong influence on the process of storing and retrieving new information into memory. Previous approaches in the cognitive neuroscience of memory have entirely focused on the individual dimension of preexisting schemas. In the real world though, much of our experiences and knowledge are collective or shared. Such social-cultural frameworks stored in collective memory may also reshape and reconfigure the construction of individual memories. Attempting to ascertain the influence of collective schema on the neural substrates of individual memories using cutting-edge brain imaging methods represents the challenge that MULTIBRAIN seeks to tackle. To achieve this goal, we will record brain activity in a group of 24 participants while there are remembering pictures from a tour at the World War II Memorial of Caen. This study will seek to identify brain areas of the prefrontal cortex encoding the organization of knowledge in collective memory using multivariate analyses of brain patterns of activation, and then to understand how such regions might modulate the recruitment of the hippocampus during episodic memory retrieval using analyses of effective connectivity. The organization of knowledge in collective memory is measured in parallel through 1) the analysis of French social memory of World War II using a corpus of 100 000 television and radio shows from the National Institute of Audiovisual, and 2) an internet task measuring the organization of individual knowledge in a large group of individuals that will allow to separate shared from non-shared memories of the World War II. Once collected, these data will help us to understand how collective schemas may reconfigure the organization of individual memories.
- Conditions
- Episodic Memory
- Being tested
- Episodic memory task, fMRI
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Episodic memory taskBehavioural
fMRIDevice
| Study group | Role | What they receive |
|---|---|---|
| Healthy participants | Experimental | Structural and functional MRI and memory assessment Receives: Behavioral: Episodic memory task; Device: fMRI |
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood Oxigen Level Dependent (BOLD) response as measured with fMRI
Measured: 1 hour
Secondary outcomes (1)
Episodic memory performances - % of accuracy
Measured: 1 hour
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jun 2014 (estimated)
- Study startOct 2014
- Primary completion14 Oct 2016
- Study completion14 Oct 2016
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Episodic MemoryStudies of the same condition, open and under way.
- More trials run by Institut National de la Santé Et de la Recherche Médicale, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 27 participants (actual)
Sponsor and investigators
- Sponsor type
- Other government
- Collaborators
- La Région Basse-Normandie, Université de Caen Normandie, University Hospital, Caen, Ecole Pratique des Hautes Etudes, Equipement d'Excellence Matrice
- Responsible party
- Sponsor
- Investigators
- Fausto Viader, PUPH, Principal investigator, University Hospital, Caen
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02172677
- Sponsor's protocol ID
- C13-46
- Other IDs
- 2014-A00126-41
- Acronym
- MULTIBRAIN_1
- Status last verified
- Oct 2017
- First submitted
- 16 Jun 2014
- Last updated
- 4 Sep 2025
- Results posted
- No
Publications
Gagnepain P, Vallee T, Heiden S, Decorde M, Gauvain JL, Laurent A, Klein-Peschanski C, Viader F, Peschanski D, Eustache F. Collective memory shapes the organization of individual memories in the medial prefrontal cortex. Nat Hum Behav. 2020 Feb;4(2):189-200. doi: 10.1038/s41562-019-0779-z. Epub 2019 Dec 16.
PubMed 31844272
Study at a glance
From the registry record, last updated by the sponsor on 4 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- ETUDE D'IMAGERIE PAR RESONANCE MAGNETIQUE FONCTIONNELLE CHEZ LE SUJET SAIN DES RELATIONS ENTRE MEMOIRE COLLECTIVE ET INDIVIDUELLE
- ClinicalTrials.gov ID
- NCT02172677
- Acronym / sponsor ID
- MULTIBRAIN_1 / C13-46
- Conditions
- Episodic Memory
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 27 participants (actual)
- Lead sponsor
- Institut National de la Santé Et de la Recherche Médicale, FranceOther government
- Collaborators
- La Région Basse-Normandie, Université de Caen Normandie, University Hospital, Caen, Ecole Pratique des Hautes Etudes, Equipement d'Excellence Matrice
- Study start
- Oct 2014
- Primary completion
- 14 Oct 2016 (actual)
- Study completion
- 14 Oct 2016 (actual)
- First posted
- 24 Jun 2014 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Schemas describe mental structures storing recurrent and organized pattern of information. Schemas may have a strong influence on the process of storing and retrieving new information into memory. Previous approaches in the cognitive neuroscience of memory have entirely focused on the individual dimension of preexisting schemas. In the real world though, much of our experiences and knowledge are collective or shared. Such social-cultural frameworks stored in collective memory may also reshape and reconfigure the construction of individual memories. Attempting to ascertain the influence of collective schema on the neural substrates of individual memories using cutting-edge brain imaging methods represents the challenge that MULTIBRAIN seeks to tackle. To achieve this goal, we will record brain activity in a group of 24 participants while there are remembering pictures from a tour at the World War II Memorial of Caen. This study will seek to identify brain areas of the prefrontal cortex encoding the organization of knowledge in collective memory using multivariate analyses of brain patterns of activation, and then to understand how such regions might modulate the recruitment of the hippocampus during episodic memory retrieval using analyses of effective connectivity. The organization of knowledge in collective memory is measured in parallel through 1) the analysis of French social memory of World War II using a corpus of 100 000 television and radio shows from the National Institute of Audiovisual, and 2) an internet task measuring the organization of individual knowledge in a large group of individuals that will allow to separate shared from non-shared memories of the World War II. Once collected, these data will help us to understand how collective schemas may reconfigure the organization of individual memories.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Healthy participants | Experimental | Behavioral: Episodic memory task, Device: fMRIStructural and functional MRI and memory assessment |
Who may qualify
- Ages
- 20 to 38 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Healthy participants between 20 and 38 years old
- Affiliated to the French national health care system
- French native speaker
- Participated in a tour trip at the Memorial of Caen within the last 3 months
- Right-handed
Key exclusion criteria (13 listed)
- Pregnancy or intent to get pregnant
- Person deprived of their liberty
- Person hospitalized without consent
- Minor
- Protected adults or people unable to give informed consent
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Episodic memory task | Behavioural | Healthy participants |
| fMRI | Device | Healthy participants |
Primary outcome
Blood Oxigen Level Dependent (BOLD) response as measured with fMRI
Time frame: 1 hour
1 secondary outcome
Episodic memory performances - % of accuracy
Time frame: 1 hour
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Sep 2025.
- Results publication: PubMed 31844272Gagnepain P, Vallee T, Heiden S, Decorde M, Gauvain JL, Laurent A, Klein-Peschanski C, Viader F, Peschanski D, Eustache F. Collective memory shapes the organization of individual memories in the medial prefrontal cortex. Nat Hum Behav. 2020 Feb;4(2):189-200. doi: 10.1038/s41562-019-0779-z. Epub 2019 Dec 16.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Fausto Viader, PUPH principal investigator
University Hospital, Caen
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Episodic memory task and fMRI in people with Episodic Memory, run by Institut National de la Santé Et de la Recherche Médicale, France at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood Oxigen Level Dependent (BOLD) response as measured with fMRI (time frame: 1 hour). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02172677, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Sep 2025.