Coronary Artery DiseasePROGRESS-CTONCT02061436
Prospective Global Registry for the Study of Chronic Total Occlusion Intervention
An observational study of Coronary Artery Disease, run by Minneapolis Heart Institute Foundation at 48 sites in 6 countries.
Trial summary
Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Coronary Artery Disease
- How many people
- 2,000 participants
- Where
- 48 sitesin 6 countries
- Study dates
- Jan 2012to Jan 2030
- How long will I take part?
- 1 Year
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients undergoing CTO PCI at each of the participating centers.
Who may be able to join
- Patients undergoing CTO PCI at each of the participating centers.
Who cannot join
- None
Trial locations and contacts
48 sites in 6 countries. Contact the study team or a site near you to ask about taking part.
48 sites in 6 countries
United States42 sites, 33 recruiting
- Completed
Appleton Cardiology
Appleton, Wisconsin, 54911
- Active, not recruiting
Piedmont Heart Institute
Atlanta, Georgia, 30309
- Recruiting
Emory University Hospital- Emory Heart and Vascular Center
Atlanta, Georgia, 30322
Wissam Jaber, MD
- Active, not recruiting
Peacehealth Cardiology
Bellingham, Washington, 98225
- Recruiting
Massachusetts General Hospital
Boston, Massachusetts, 02114
Bobby Yeh, MD, MBA, RYEH@mgh.harvard.edu
Farouc Jaffer, MD, PhD
- Recruiting
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215
Linda Valsdottir, 6176327653, lvalsdot@bidmc.harvard.edu
Robert W Yeh, MD, MBA
- Recruiting
Maimonides Medical Center
Brooklyn, New York, 11219
Bilal Malik, MD
- Recruiting
Trinity Medical WNY
Buffalo, New York, 14221
Henry Meltser, MD
- Active, not recruiting
Northwestern Bluhm Cardiovascular Institute
Chicago, Illinois, 60611
- Recruiting
The Christ Hospital Ohio Heart & Vascular
Cincinnati, Ohio, 45219
Robert Riley, MD
- Recruiting
University Hospitals (UH) Case Western Reserve University
Cleveland, Ohio, 44106
Farshad Forouzandeh, MD, PhD
- Recruiting
Cleveland Clinic
Cleveland, Ohio, 44195
Jaikirshan Khatri, MD
- Recruiting
University of Texas Southwestern Medical Center
Dallas, Texas, 75216
Emmanouil S Brilakis, MD, PhD, esbrilakis@gmail.com
Emmanouil S Brilakis, MD, PhD
- Recruiting
VA Dallas Medical Center
Dallas, Texas, 75216
Emmanouil S Brilakis, MD, PhD, (214) 857-1547 ext. 71547, esbrilakis@gmail.com
Shuaib Abdullah, MD, Shuaib.Abdullah@va.gov
- Recruiting
Baylor Heart and Vascular Hospital
Dallas, Texas, 75226
James Choi, MD, James.Choi@baylorhealth.edu
James Choi, MD
- Recruiting
Henry Ford Medical Center
Detroit, Michigan, 48202
Khaldoon Alaswad, MD, kalaswa1@hfhs.org
Khaldoon Alaswad, MD
- Active, not recruiting
Houston Methodist Hospital
Houston, Texas, 77030
- Recruiting
St. Vincent Heart Center
Indianapolis, Indiana, 46260
Charles Orr, MD
- Recruiting
Memorial Hospital
Jacksonville, Florida, 32216
Larry Van-Tomas Crisco
- Active, not recruiting
Mid America Heart Institute
Kansas City, Missouri, 64131
- Recruiting
Kettering Health Network
Kettering, Ohio, 45429
Niranjan Reddy, MD
- Recruiting
Little Rock VA Medical Center
Little Rock, Arkansas, 72205
Barry Uretsky, MD, Barry.Uretsky@va.gov
Barry Uretsky, MD
- Recruiting
Medical Center of the Rockies
Loveland, Colorado, 80538
Anthony Doing, MD, anthony.doing@uchealth.org
Anthony Doing, MD
- Recruiting
Wellstar Health System
Marietta, Georgia, 30060
Abdul Sheikh
- Recruiting
Minneapolis Heart Institute
Minneapolis, Minnesota, 55407
Emmanouil S Brilakis, MD, PhD, 612-863-3900, esbrilakis@gmail.com
Emmanouil S Brilakis, MD, PhD
- Recruiting
Minneapolis VA Healthcare System and University of Minnesota
Minneapolis, Minnesota, 55417
Santiago Garcia, MD, garci205@umn.edu
Santiago Garcia, MD
- Recruiting
Tristar Centennial Medical Center
Nashville, Tennessee, 37203
Brian Jefferson, MD
Taral Patel, MD
- Recruiting
Carolina East Medical Center
New Bern, North Carolina, 28560
David Jessup, MD, djessup@carolinaeasthealth.com
David Jessup, MD
- Recruiting
Tulane University Heart and Vascular Institute
New Orleans, Louisiana, 70112
Suzanne Bowers, RN, 5049882030, sbowers@tulane.edu
Nana Asafu-Adjaye, 5049886508, nasafuad@tulane.edu
- Recruiting
Columbia University
New York, New York, 10032
Dimitri Karmpaliotis, MD, dk2787@columbia.edu
Dimitri Karmpaliotis, MD
- Recruiting
Oklahoma City VA Medical Center
Oklahoma City, Oklahoma, 73117
Faisal Latif, MD
- Completed
Banner Samaritan Health Center
Phoenix, Arizona, 85006
- Recruiting
University of Pittsburgh Medical Center Presbyterian
Pittsburgh, Pennsylvania, 15213
Catalin Toma, MD, (412) 647-6000, tomac@upmc.edu
Catalin Toma, MD
- Recruiting
Baylor Scott & White Research Institute-The Heart Hospital Baylor Plano
Plano, Texas, 75093
Srinivasa Potluri, MD
- Recruiting
Baylor Scott and White Research Institute/ The Heart Hospital Baylor Plano
Plano, Texas, 75093
Julie McCracken, 469-814-4717, Julie.McCracken@bswhealth.org
Rachelle Winkle, 469-814-4183, Rachelle.Winkle@bswhealth.org
- Recruiting
The Heart Hospital Baylor Plano
Plano, Texas, 75093
Elizabeth Holper, MD, Elizabeth.Holper@bswhealth.org
Elizabeth Holper, MD
- Recruiting
Providence Heart & Vascular Institute
Portland, Oregon, 97225
Jason Wollmuth, MD
- Recruiting
San Diego VAMC and University of California
San Diego, California, 92161
Mitul Patel, MD, mpatel@ucsd.edu
Mitul Patel, MD
- Active, not recruiting
Torrance Memorial Medical Center
Torrance, California, 90505
- Recruiting
Oklahoma Heart Institute at Hillcrest Medical Center
Tulsa, Oklahoma, 74104
Raj Chandwaney, MD
- Active, not recruiting
Providence Health Center
Waco, Texas, 76712
- Recruiting
WellSpan Heart & Vascular
York, Pennsylvania, 17405
William Nicholson, MD
Greece2 sites, 2 recruiting
- Recruiting
Korgialeneio-Benakeio Hellenic Red Cross General Hospital of Athens
Athens, Attica, 11526
Michalis Koutouzis, MD, mkoutouzis@0310.syzefxis.gov.gr
Michalis Koutouzis, MD
- Recruiting
Henry Hunant Hospital Center
Athens
Vaios Tzifos, MD
Canada1 site, 1 recruiting
- Recruiting
St. Boniface General Hospital
Winnipeg, Manitoba, R3E 0W3
Basem Elbarouni, MD
Egypt1 site, 1 recruiting
- Recruiting
Aswan Heart Centre
Aswān
Ahmed M ElGuindy, MD
Lebanon1 site, 1 recruiting
- Recruiting
St. George Hospital University Medical Center
Beirut
Nidal Abi Rafah, MD
Russia1 site, 1 recruiting
- Recruiting
Meshalkin Novosibirsk Research Institute
Novosibirsk, Novosibirsk Oblast, 630055
Oleg Krestyaninov, MD, o_krestyaninov@meshalkin.ru
Oleg Krestyaninov, MD
About this study
Official title: Multicenter Registry of Chronic Total Occlusion Interventions
Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. The goal of this multicenter, investigator initiated registry is to collect information on treatment strategies and outcomes of consecutive patients undergoing CTO PCI among various participating centers. The information collected will be used to determine the frequency of CTO PCI performed at the participating sites and examine the procedural strategies utilized, and the procedural (both immediate and during follow-up) outcomes.
- Conditions
- Coronary Artery Disease
- Keywords
- chronic total occlusion, percutaneous coronary intervention
- Medical subject headings
- Coronary Artery Disease
What is being measured
The primary outcome is the main question the study is designed to answer.
procedural success of chronic total occlusion PCI
Procedural success is defined as achievement of technical success with no in-hospital major adverse cardiac events (MACE). In-hospital MACE includes any of the following adverse events prior to hospital discharge: death from any cause, Q-wave myocardial infarction, urgent repeat target vessel revascularization with PCI or coronary bypass surgery, tamponade requiring pericardiocentesis or surgery, or stroke.
Measured: discharge from the hospital after PCI, which usually happens the day after the procedure
Secondary outcomes (2)
technical success of chronic total occlusion PCI
Technical success of CTO PCI was defined as successful CTO revascularization with achievement of <30% residual diameter stenosis within the treated segment and restoration of TIMI grade 3 antegrade flow.
Measured: discharge from the hospital after PCI, which usually happens the day after the procedure
major adverse cardiovascular events
In-hospital major adverse cardiovascular events (MACE) include any of the following adverse events prior to hospital discharge: death from any cause, Q-wave myocardial infarction, urgent repeat target vessel revascularization with PCI or coronary bypass surgery, tamponade requiring pericardiocentesis or surgery, or stroke.
MACE during clinical follow-up include death, myocardial infarction, target lesion and target vessel revascularization.
Measured: discharge from the hospital after PCI (which usually happens the day after the procedure) and during clinically-indicated follow-up. There are no pre-specified follow-up time periods - patients are assessed if and when they come to receive clinical care.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Feb 2014 (estimated)
- Study startJan 2012
- Primary completionJan 2030 (estimated)
- Study completionJan 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (52)Papers the sponsor has linked to this study.
- Other trials for Coronary Artery DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 2,000 participants (estimated)
- Target duration
- 1 Year
Sponsor and investigators
- Lead sponsor
- Minneapolis Heart Institute Foundation
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Emmanouil S Brilakis, MD, PhD, Principal investigator, Minneapolis Heart Institute Foundation
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02061436
- Sponsor's protocol ID
- #11-099
- Acronym
- PROGRESS-CTO
- Status last verified
- Aug 2026
- First submitted
- 28 Jan 2014
- Last updated
- 19 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Christopoulos G, Menon RV, Karmpaliotis D, Alaswad K, Lombardi W, Grantham JA, Michael TT, Patel VG, Rangan BV, Kotsia AP, Lembo N, Kandzari DE, Lee J, Kalynych A, Carlson H, Garcia S, Banerjee S, Thompson CA, Brilakis ES. Application of the "hybrid approach" to chronic total occlusions in patients with previous coronary artery bypass graft surgery (from a Contemporary Multicenter US registry). Am J Cardiol. 2014 Jun 15;113(12):1990-4. doi: 10.1016/j.amjcard.2014.03.039. Epub 2014 Mar 31.
PubMed 24793678Christopoulos G, Karmpaliotis D, Alaswad K, Lombardi WL, Grantham JA, Rangan BV, Kotsia AP, Lembo N, Kandzari DE, Lee J, Kalynych A, Carlson H, Garcia S, Banerjee S, Thompson CA, Brilakis ES. The efficacy of "hybrid" percutaneous coronary intervention in chronic total occlusions caused by in-stent restenosis: insights from a US multicenter registry. Catheter Cardiovasc Interv. 2014 Oct 1;84(4):646-51. doi: 10.1002/ccd.25465. Epub 2014 Jul 4.
PubMed 24585508Christopoulos G, Karmpaliotis D, Wyman MR, Alaswad K, McCabe J, Lombardi WL, Grantham JA, Marso SP, Kotsia AP, Rangan BV, Garcia SA, Lembo N, Kandzari D, Lee J, Kalynych A, Carlson H, Thompson CA, Banerjee S, Brilakis ES. Percutaneous intervention of circumflex chronic total occlusions is associated with worse procedural outcomes: insights from a Multicentre US Registry. Can J Cardiol. 2014 Dec;30(12):1588-94. doi: 10.1016/j.cjca.2014.07.007. Epub 2014 Jul 16.
PubMed 25442459Christopoulos G, Menon RV, Karmpaliotis D, Alaswad K, Lombardi W, Grantham A, Patel VG, Rangan BV, Kotsia AP, Lembo N, Kandzari D, Carlson H, Garcia S, Banerjee S, Thompson CA, Brilakis ES. The efficacy and safety of the "hybrid" approach to coronary chronic total occlusions: insights from a contemporary multicenter US registry and comparison with prior studies. J Invasive Cardiol. 2014 Sep;26(9):427-32.
PubMed 25198485Sapontis J, Christopoulos G, Grantham JA, Wyman RM, Alaswad K, Karmpaliotis D, Lombardi WL, McCabe JM, Marso SP, Kotsia AP, Rangan BV, Christakopoulos GE, Garcia S, Thompson CA, Banerjee S, Brilakis ES. Procedural failure of chronic total occlusion percutaneous coronary intervention: Insights from a multicenter US registry. Catheter Cardiovasc Interv. 2015 Jun;85(7):1115-22. doi: 10.1002/ccd.25807. Epub 2015 Feb 3.
PubMed 25557905Christopoulos G, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman RM, Lombardi WL, Menon RV, Grantham JA, Kandzari DE, Lembo N, Moses JW, Kirtane AJ, Parikh M, Green P, Finn M, Garcia S, Doing A, Patel M, Bahadorani J, Tarar MN, Christakopoulos GE, Thompson CA, Banerjee S, Brilakis ES. Application and outcomes of a hybrid approach to chronic total occlusion percutaneous coronary intervention in a contemporary multicenter US registry. Int J Cardiol. 2015 Nov 1;198:222-8. doi: 10.1016/j.ijcard.2015.06.093. Epub 2015 Jun 27.
PubMed 26189193Christopoulos G, Wyman RM, Alaswad K, Karmpaliotis D, Lombardi W, Grantham JA, Yeh RW, Jaffer FA, Cipher DJ, Rangan BV, Christakopoulos GE, Kypreos MA, Lembo N, Kandzari D, Garcia S, Thompson CA, Banerjee S, Brilakis ES. Clinical Utility of the Japan-Chronic Total Occlusion Score in Coronary Chronic Total Occlusion Interventions: Results from a Multicenter Registry. Circ Cardiovasc Interv. 2015 Jul;8(7):e002171. doi: 10.1161/CIRCINTERVENTIONS.114.002171.
PubMed 26162857Alaswad K, Menon RV, Christopoulos G, Lombardi WL, Karmpaliotis D, Grantham JA, Marso SP, Wyman MR, Pokala NR, Patel SM, Kotsia AP, Rangan BV, Lembo N, Kandzari D, Lee J, Kalynych A, Carlson H, Garcia SA, Thompson CA, Banerjee S, Brilakis ES. Transradial approach for coronary chronic total occlusion interventions: Insights from a contemporary multicenter registry. Catheter Cardiovasc Interv. 2015 Jun;85(7):1123-9. doi: 10.1002/ccd.25827. Epub 2015 Feb 3.
PubMed 25640902Danek BA, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Patel M, Bahadorani J, Lombardi WL, Wyman MR, Grantham JA, Doing A, Moses JW, Kirtane A, Parikh M, Ali ZA, Kalra S, Kandzari DE, Lembo N, Garcia S, Rangan BV, Thompson CA, Banerjee S, Brilakis ES. Use of antegrade dissection re-entry in coronary chronic total occlusion percutaneous coronary intervention in a contemporary multicenter registry. Int J Cardiol. 2016 Jul 1;214:428-37. doi: 10.1016/j.ijcard.2016.03.215. Epub 2016 Apr 6.
PubMed 27088405Karacsonyi J, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman MR, Lombardi WL, Grantham JA, Kandzari DE, Lembo N, Moses JW, Kirtane AJ, Parikh MA, Green P, Finn M, Garcia S, Doing A, Patel M, Bahadorani J, Martinez Parachini JR, Resendes E, Rangan BV, Ungi I, Thompson CA, Banerjee S, Brilakis ES. Effect of Previous Failure on Subsequent Procedural Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention (from a Contemporary Multicenter Registry). Am J Cardiol. 2016 Apr 15;117(8):1267-71. doi: 10.1016/j.amjcard.2016.01.021. Epub 2016 Jan 28.
PubMed 26899493Nguyen-Trong PK, Rangan BV, Karatasakis A, Danek BA, Christakopoulos GE, Martinez-Parachini JR, Resendes E, Ayers CR, Luna M, Abdullah S, Kumbhani DJ, Addo T, Grodin J, Banerjee S, Brilakis ES. Predictors and Outcomes of Side-Branch Occlusion in Coronary Chronic Total Occlusion Interventions. J Invasive Cardiol. 2016 Apr;28(4):168-73. Epub 2016 Jan 15.
PubMed 26773239Christopoulos G, Kandzari DE, Yeh RW, Jaffer FA, Karmpaliotis D, Wyman MR, Alaswad K, Lombardi W, Grantham JA, Moses J, Christakopoulos G, Tarar MNJ, Rangan BV, Lembo N, Garcia S, Cipher D, Thompson CA, Banerjee S, Brilakis ES. Development and Validation of a Novel Scoring System for Predicting Technical Success of Chronic Total Occlusion Percutaneous Coronary Interventions: The PROGRESS CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention) Score. JACC Cardiovasc Interv. 2016 Jan 11;9(1):1-9. doi: 10.1016/j.jcin.2015.09.022.
PubMed 26762904Karatasakis A, Tarar MN, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman RM, Lombardi WL, Grantham JA, Kandzari DE, Lembo NJ, Moses JW, Kirtane AJ, Parikh M, Garcia S, Doing A, Pershad A, Shah A, Patel M, Bahadorani J, Shoultz CA Jr, Danek BA, Thompson CA, Banerjee S, Brilakis ES. Guidewire and microcatheter utilization patterns during antegrade wire escalation in chronic total occlusion percutaneous coronary intervention: Insights from a contemporary multicenter registry. Catheter Cardiovasc Interv. 2017 Mar 1;89(4):E90-E98. doi: 10.1002/ccd.26568. Epub 2016 May 17.
PubMed 27184465Christakopoulos GE, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman RM, Lombardi W, Grantham JA, Kandzari DA, Lembo N, Moses JW, Kirtane A, Parikh M, Green P, Finn M, Garcia S, Doing A, Patel M, Bahadorani J, Christopoulos G, Karatasakis A, Thompson CA, Banerjee S, Brilakis ES. Contrast Utilization During Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From a Contemporary Multicenter Registry. J Invasive Cardiol. 2016 Jul;28(7):288-94.
PubMed 27342206Nguyen-Trong PK, Alaswad K, Karmpaliotis D, Lombardi W, Grantham JA, Lembo N, Kandzari D, Karatasakis A, Karacsonyi J, Danek BA, Rangan BV, Roesle M, Ayers CR, Thompson CA, Banerjee S, Brilakis ES. Use of Saphenous Vein Bypass Grafts for Retrograde Recanalization of Coronary Chronic Total Occlusions: Insights From a Multicenter Registry. J Invasive Cardiol. 2016 Jun;28(6):218-24.
PubMed 27236005