Cardiovascular DiseasePhase 3SPIRE-2NCT01975389
The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects
A Phase 3 study testing bococizumab (PF-04950615) in people with Cardiovascular Disease, run by Pfizer at 1,595 sites in 35 countries.
Trial summary
This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and unstable angina requiring urgent revascularization in high risk subjects who are receiving… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiovascular Disease
- What is being tested?
- bococizumab (PF-04950615)
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 10,564 participants
- Where
- 1,595 sitesin 35 countries
- Study dates
- 29 Oct 2013to 3 Apr 2017
- Phase
- Phase 3
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Must be on background lipid lowering treatment.
- Must be at high risk of a CV event.
- Must have an LDL C >/=100 mg/dL (2.6 mmol/L) OR non HDL C >/=130 mg/dL (3.4 mmol/L).
Who cannot join
- Planned coronary (PCI or CABG) or other arterial revascularization.
- New York Heart Association Class IV congestive heart failure or left ventricular ejection fraction < 25% by cardiac imaging.
- Chronic renal insufficiency with creatinine clearance of <30 ml/min/1.73m^2 by MDRD formula or with end state renal disease on dialysis.
- History of hemorrhagic stroke.
- Prior exposure to bococizumab or other investigational PCSK9 inhibitor.
Trial locations and contacts
1,595 sites in 35 countries.
1377 sites in 35 countries
United States300 sites
Abington Hosptial
Abington, Pennsylvania, 19001
Radiant Research, Inc
Akron, Ohio, 44311
Albany Medical College, Division of Community Endocrinology
Albany, New York, 12206
Albuquerque Clinical Trials, Inc.
Albuquerque, New Mexico, 87102
Endeavor Medical Research
Alpena, Michigan, 49707
Clinical Research Associates of Central PA
Altoona, Pennsylvania, 16602
PharmaTex Research
Amarillo, Texas, 79106
Cardiology Consultants of Orange County Medical Group, Inc.
Anaheim, California, 92801
Alaska Heart Institute
Anchorage, Alaska, 99508
St. Joseph Mercy Health System (Drug shipment Only)
Ann Arbor, Michigan, 48106
University of Michigan - Domino Farms
Ann Arbor, Michigan, 48106
Anne Arundel Medical Center
Annapolis, Maryland, 21401
MedStar Cardiology Associates
Annapolis, Maryland, 21401
Arlington Family Research Center, Inc.
Arlington, Texas, 76012
Northwest Heart Clinical Research, LLC
Arlington Heights, Illinois, 60005
Integrated Medical Research PC
Ashland, Oregon, 97520
Ernest Hendrix, MD, PC
Athens, Alabama, 35611
North Alabama Research Center, LLC
Athens, Alabama, 35611
Atlanta Diabetes Associates
Atlanta, Georgia, 30318
Emory University Hospital
Atlanta, Georgia, 30322
Atlanta Center For Medical Research
Atlanta, Georgia, 30331
ACRC - Cardiology
Atlantis, Florida, 33462
Maine Research Associates
Auburn, Maine, 04210
Texas Diabetes & Endocrinology
Austin, Texas, 78731
Austin Heart, PLLC
Austin, Texas, 78756
Premier Valley Medical Group
Bakersfield, California, 93309
MedStar Chesapeake CardioVascular Associates
Baltimore, Maryland, 21204
MedStar Union Memorial Heart Specialists
Baltimore, Maryland, 21218
Maryland Cardiovascular Specialists
Baltimore, Maryland, 21229
Overlea Personal Physicians
Baltimore, Maryland, 21236
Shahid Saeed, MD, PC
Baltimore, Maryland, 21237
Acadia Clinical Research, LLC
Bangor, Maine, 04401
Acadia Clinical Research
Bangor, Maine, 04401
John V. Bernard, MD dba Wellness and Research Center
Belvidere, New Jersey, 07823
Cardiovascular Research Foundation of Southern California
Beverly Hills, California, 90210
Westside Medical Associates of Los Angeles
Beverly Hills, California, 90211
Quest Research Institute
Bingham Farms, Michigan, 48025
Central Alabama Research
Birmingham, Alabama, 35209
Clinical Research Advantage, Inc./Simon Williamson Clinic
Birmingham, Alabama, 35211
The Kirklin Clinic
Birmingham, Alabama, 35233
Birmingham Heart Clinic, P.C.
Birmingham, Alabama, 35235
University of Alabama at Birmingham (Drug Shipment)
Birmingham, Alabama, 35294
Elite Clinial Trials, LLLP
Blackfoot, Idaho, 83221
Elite Clinical Trials (Additional Administrative Room / Exam Rooms)
Blackfoot, Idaho, 83221
Grace Research, LLC
Bossier City, Louisiana, 71111
Utah Cardiology, PC
Bountiful, Utah, 84010
Connecticut Clinical Research, LLC
Bridgeport, Connecticut, 06606
Bridgeport Hospital
Bridgeport, Connecticut, 06610
Advanced Heart Care LLC
Bridgewater, New Jersey, 08807
Sorin Medical, P.C.
Brooklyn, New York, 11214
NY Total Medical Care, PC
Brooklyn, New York, 11215
NY Scientific
Brooklyn, New York, 11235
Investigators Research Group, LLC
Brownsburg, Indiana, 46112
Southbay Pharma Research
Buena Park, California, 90620
Buffalo Heart Group, Llp
Buffalo, New York, 14215
Office of Daniel W. Gottlieb, MD, PS
Burien, Washington, 98166
Burke Internal Medicine & Research
Burke, Virginia, 22015
Clinical Research Institute of Northern Virginia
Burke, Virginia, 22015
St. Luke's Idaho Cardiology Associates
Caldwell, Idaho, 83605
Cranbrook Cardiology Research Associates
Cape Elizabeth, Maine, 04107
Pioneer Medical Group
Cerritos, California, 90703
Aztec Medical Research, LLC
Channelview, Texas, 77530
Coastal Cardiology
Charleston, South Carolina, 29407
Novant Health Clinical Research
Charlotte, North Carolina, 28204
Novant Health Heart and Vascular Institute
Charlotte, North Carolina, 28204
Sensenbrenner Primary Care
Charlotte, North Carolina, 28277
IHA Chelsea Family & Internal Medicine
Chelsea, Michigan, 48118
Lourdes Cardiology Services
Cherry Hill, New Jersey, 08034
Clinical Research Advantage, Inc./Michigan Avenue Internists
Chicago, Illinois, 60604
Apex Medical Research, AMR, Inc.
Chicago, Illinois, 60616
Clinical Research Advantage,Inc./Medical and Procedural Specilaists of Illinois
Chicago, Illinois, 60631
The Lindner Center for Research and Education at The Christ Hospital
Cincinnati, Ohio, 45219
Metabolic and Atherosclerosis Research Center
Cincinnati, Ohio, 45227
Sterling Research Group, Ltd.
Cincinnati, Ohio, 45246
Mid-Cumberland Infectious Disease Consultants, PLC
Clarksville, Tennessee, 37043
NC Heart and Vascular
Clayton, North Carolina, 27520
GulfCoast Endocrine and Diabetes Center
Clearwater, Florida, 33756
Morton Plant Mease Health Care, Inc. Cardiovascular Research
Clearwater, Florida, 33756
Rapid Medical Research, Inc.
Cleveland, Ohio, 44122
Cleveland Clinic - Taussig Cancer Institute
Cleveland, Ohio, 44195
Collierville Medical Specialists
Collierville, Tennessee, 38017
Colorado Springs Health Partners
Colorado Springs, Colorado, 80906
Lynn Institute of the Rockies
Colorado Springs, Colorado, 80909
Memorial Hospital: University of Colorado Health
Colorado Springs, Colorado, 80909
Missouri Cardiovascular Specialists, LLP
Columbia, Missouri, 65201
Columbus Regional Research Institute
Columbus, Georgia, 31904
Radiant Research, Inc.
Columbus, Ohio, 43212
Optimed Research, LTD
Columbus, Ohio, 43235
John Muir Physician Network Clinical Research Center
Concord, California, 94520
Rockdale Medical Research Associates
Conyers, Georgia, 30094
Team Medical Research
Coral Gables, Florida, 33134
Corsicana Medical Research, PLLC
Corsicana, Texas, 75110
NYU Hudson Valley Cardiology
Cortlandt Manor, New York, 10567
West Broadway Clinic
Council Bluffs, Iowa, 51501
Clinical Research Advantage, Inc.
Council Bluffs, Iowa, 51503
Georgia Heart Specialists, LLC
Covington, Georgia, 30014
Avant Research Associates, LLC
Crowley, Louisiana, 70526
Atlantic Ave Medical Clinic Inc.
Cudahy, California, 90201
Protenium Clinical Research, LLC
Dallas, Texas, 75208
VA North Texas Health Care System - Dallas VAMC
Dallas, Texas, 75216
Baylor Heart and Vascular Institute
Dallas, Texas, 75226
Dallas Diabetes and Endocrine Center
Dallas, Texas, 75230
Cardiovascular Research Institute of Dallas
Dallas, Texas, 75231
Radiant Research, Inc.
Dallas, Texas, 75231
Research Institute of Dallas
Dallas, Texas, 75231
Midwest Cardiovascular Research Foundation
Davenport, Iowa, 52803
Dayton Heart Center
Dayton, Ohio, 45414
Premier Health Specialists, Inc. (dba Dayton Heart Center)
Dayton, Ohio, 45414
PriMed Clinical Research
Dayton, Ohio, 45419
The Heart Group, PA
Daytona Beach, Florida, 32114
Cardiology Associates Research Company
Daytona Beach, Florida, 32117
Neurostudies.net, LLC
Decatur, Georgia, 30033
Delaware Research Group, LLC
Delaware, Ohio, 43015
The Cardiology Center
Delray Beach, Florida, 33484
Lynn Institute of Denver
Denver, Colorado, 80246
Continental Research Corp
Doral, Florida, 33126
Care Research Center Inc
Doral, Florida, 33166
Integrity Clinical Research, LLC
Doral, Florida, 33166
Moonshine Research Center, Inc.
Doral, Florida, 33166
Multani Medical Group
Downey, California, 90241
Brandywine Clinical Research
Downingtown, Pennsylvania, 19335-2620
Doylestown Cardiology Associates - VIAA
Doylestown, Pennsylvania, 18901
Doylestown Health Cardiology, a division of Doylestown Health Physicians
Doylestown, Pennsylvania, 18901
Duluth Clinic, dba Essentia Health Duluth Clinic Investigational Drug Room
Duluth, Minnesota, 55805
St. Mary's Medical Center dba Essentia Health St. Mary's Medical Center
Duluth, Minnesota, 55805
St. Mary's Medical Center
Duluth, Minnesota, 55805
The Duluth Clinic, Ltd.
Duluth, Minnesota, 55805
Alta Pharmaceutical Research Center
Dunwoody, Georgia, 30338
Radiant Research, Inc.
Edina, Minnesota, 55435
Doctors Hospital At Renaissance
Edinburg, Texas, 78539
Triwest Research Associates, LLC
El Cajon, California, 92020
USMA Clinical Research
Elizabeth, New Jersey, 07201
Central Cardiology Associates Research
Elizabethtown, Kentucky, 42701
Investigative Clinical Research of Indiana, LLC
Elwood, Indiana, 46036
North Ohio Heart Center (Administrative Only)
Elyria, Ohio, 44035
North Ohio Heart Center
Elyria, Ohio, 44035
Diagnamics Inc.
Encinitas, California, 92024
T. Joseph Raoof, Md, Inc/Encino Research Center
Encino, California, 91436
Aviva Research
Escondido, California, 92025
Evanston Premier Healthcare Research, LLC
Evanston, Illinois, 60201
Deaconess Clinic Downtown
Evansville, Indiana, 47713
Clinical Research Advantage, Inc.
Evansville, Indiana, 47714
MediSphere Medical Research Center, LLC
Evansville, Indiana, 47714
Clinical Research Advantage, Inc. / Family Medicine Associates
Evansville, Indiana, 47725
Deaconess Clinic Mt. Pleasant
Evansville, Indiana, 47725
Exemplar Research Inc
Fairmont, West Virginia, 26554
Virginia Heart
Falls Church, Virginia, 22042
Seven Corners Medical Research Center
Falls Church, Virginia, 22044
Lillestol Research LLC
Fargo, North Dakota, 58103
Amh/Feasterville Family Health Care Center
Feasterville-Trevose, Pennsylvania, 19053
Invesclinic, LLC
Fort Lauderdale, Florida, 33308
The Office of Dr. Alan Graff, MD, PA
Fort Lauderdale, Florida, 33308
Broward Health Medical Center
Fort Lauderdale, Florida, 33316
The Office of Maxine E. Hamilton, MD, PA
Fort Lauderdale, Florida, 33316
Appalachian Cardiovascular Associates
Fort Payne, Alabama, 35967
Amir Malik Research
Fort Worth, Texas, 76104
The Medical Group Of Texas
Fort Worth, Texas, 76104
Rockwood Medical Clinic
Fort Worth, Texas, 76164
MetroWest Medical Center - Pharmacy Department
Framingham, Massachusetts, 01702
MetroWest Medical Center Research Clinic
Framingham, Massachusetts, 01702
MetroWest Medical Center
Framingham, Massachusetts, 01702
American Health Network of Indiana LLC
Franklin, Indiana, 46131
Valley Research
Fresno, California, 93720
St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare
Fullerton, California, 92835
San Gabriel Clinical Research, LLC
Georgetown, Texas, 78626
Stern Cardiovascular Foundation, Inc.
Germantown, Tennessee, 38138
Maryland Heart Associates, LLC
Glen Burnie, Maryland, 21061
Phoenix Heart, PLLC
Glendale, Arizona, 85306
Arrowhead Internal Medicine
Glendale, Arizona, 85308
Western Colorado Research, LLC
Glenwood Springs, Colorado, 81601
Minneapolis Clinic of Neurology
Golden Valley, Minnesota, 55422
Healthy Heart Cardiology
Grandville, Michigan, 49418
Prevea Clinic, Inc.
Green Bay, Wisconsin, 54303
American Health Network of Indiana LLC
Greenfield, Indiana, 46140
LeBauer Cardiovascular Research Foundation
Greensboro, North Carolina, 27401
Upstate Pharmaceutical Research
Greenville, South Carolina, 29615
Mountain View Clinical Research, Inc.
Greer, South Carolina, 29651
Fundamental Research, LLC
Gulf Shores, Alabama, 36542
Avant Research Associates, LLC
Guntersville, Alabama, 35976
Clinical Investigation Specialists, Inc
Gurnee, Illinois, 60031
Boyett Health Services
Hamilton, Alabama, 35570
Lourdes Cardiology Services
Hammonton, New Jersey, 08037
State Of The Art Research, LLC
Hialeah, Florida, 33010
Direct Helpers Medical Center Inc
Hialeah, Florida, 33012
Clinical Trials of America, Inc.
Hickory, North Carolina, 28601
Carolina Cardiology Cornerstone
High Point, North Carolina, 27262
Hillsboro Cardiology, PC
Hillsboro, Oregon, 97123
Research Physicians Network Alliance
Hollywood, Florida, 33021
Pines Clinical Research, Inc.
Hollywood, Florida, 33024
East-West Medical Research Institute
Honolulu, Hawaii, 96814
Heart Care Associates, P.C.
Hopewell, Virginia, 23860
East Texas Cardiology PA
Houston, Texas, 77002
Spring Clinical Research
Houston, Texas, 77002
Med Tech Research, LP
Houston, Texas, 77024
Prime Care Medical Group
Houston, Texas, 77024
Associates in Medicine, PA
Houston, Texas, 77027
Alan S. Hoffman, M.D.
Houston, Texas, 77030
Baylor College of Medicine
Houston, Texas, 77030
Investigational Product Shipment Address TO: Investigational Drug Services (IDS),
Houston, Texas, 77030
Centex Studies, Inc.
Houston, Texas, 77058
Northwest Houston Cardiology
Houston, Texas, 77070
Texas Center For Drug Development, Inc.
Houston, Texas, 77081
Private Practice Leadership, LLC
Houston, Texas, 77094
The Office of Saadat Ansari MD LLC
Huntsville, Alabama, 35801
Protenium Clinical Research
Hurst, Texas, 76054
Hutchinson Clinic, P.A
Hutchinson, Kansas, 67502
University of Iowa-College of Public Health-Preventive Intervention Center
Iowa City, Iowa, 52242
East Coast Institute for Research, LLC
Jacksonville, Florida, 32204
Westside Center for Clinical Research
Jacksonville, Florida, 32205
River City Clinical Research
Jacksonville, Florida, 32207
East Coast Institute for Research, LLC
Jacksonville, Florida, 32216
East Coast Institute for Reserach, LLC
Jacksonville, Florida, 32216
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216
The Office of Rachel Day
Jacksonville, Florida, 32216
Baker-Gilmore Cardiovascular Institute
Jacksonville, Florida, 32223
Solutions Through Advanced Research, Inc.
Jacksonville, Florida, 32256
Greater Pittsburgh Vascular
Jefferson Hills, Pennsylvania, 15025
Westside Family Medical Center, Pc
Kalamazoo, Michigan, 49009
Glacier View Research Institute, Cardiology
Kalispell, Montana, 59901
University Of Kansas Medical Center
Kansas City, Kansas, 66160
Saint Luke's Lipid and Diabetes Research Center
Kansas City, Missouri, 64111
Kansas City VA Medical Center
Kansas City, Missouri, 64128-2226
Clinical Investigation Specialists, Inc.
Kenosha, Wisconsin, 53142
South Texas Cardiovascular Consultants, PLLC
Kerrville, Texas, 78028
Holston Medical Group
Kingsport, Tennessee, 37660
New Phase Research & Development
Knoxville, Tennessee, 37909
PMG Research,Inc d/b/a PMG Research of Knoxville
Knoxville, Tennessee, 37912
Cardiovascular Research of Knoxville
Knoxville, Tennessee, 37917
New Orleans Center for Clinical Research
Knoxville, Tennessee, 37920
Volunteer Research Group
Knoxville, Tennessee, 37920
Omnibus Clinical Research
La Palma, California, 90623
Alliance Research Centers
Laguna Hills, California, 92653
Prime Care Clinical Research Center
Laguna Hills, California, 92653
Centex Studies
Lake Charles, Louisiana, 70601
Imperial Health, LLP
Lake Charles, Louisiana, 70601
Meridien Research
Lakeland, Florida, 33805
Detweiler Family Medicine and Associates, PC
Lansdale, Pennsylvania, 19446
Green and Seidner Family Practice Associates
Lansdale, Pennsylvania, 19446
Sparrow Clinical Research Institute
Lansing, Michigan, 48912
Sparrow Thoracic & Cardiovascular Institute
Lansing, Michigan, 48912
The Heart Institute at Largo
Largo, Florida, 33770
AB Clinical Trials
Las Vegas, Nevada, 89119
Clinical Research of South Nevada
Las Vegas, Nevada, 89121
Clinical Research Advantage, Inc.
Las Vegas, Nevada, 89128
Scott Research,Inc
Laurelton, New York, 11413
Utah Cardiology, P.C.
Layton, Utah, 84041
Clinical Trials of America- NC, LLC
Lenoir, North Carolina, 28645
Family Medical Associates
Levittown, Pennsylvania, 19056
The Research Group of Lexington, LLC
Lexington, Kentucky, 40503
Clinical Trials Research
Lincoln, California, 95648
Bryan Heart
Lincoln, Nebraska, 68506
NJ Heart
Linden, New Jersey, 07036
Arkansas Heart Hospital Clinic
Little Rock, Arkansas, 72211
Arkansas Site Management Services, LLC
Little Rock, Arkansas, 72211
South Denver Cardiology Associates, PC
Littleton, Colorado, 80120
SJH Cardiology Associates
Liverpool, New York, 13088
Detroit Clinical Research Center, PC
Livonia, Michigan, 48154
Arysmed LLC
Lodi, New Jersey, 07644
Long Beach Memorial Medical Center
Long Beach, California, 90806
North Ohio Heart Center
Lorain, Ohio, 44053
American Institute of Research
Los Angeles, California, 90017
Intermed Group
Los Angeles, California, 90017
Academic Medical Research Institute
Los Angeles, California, 90022
Eastside Clinical Research Associates
Los Angeles, California, 90022
Richard S. Cherlin, MD
Los Gatos, California, 95032
L-MARC
Louisville, Kentucky, 40213
Caprock Cardiac Center Research Institute Inc.
Lubbock, Texas, 79410
Lutherville Personal Physicians
Lutherville, Maryland, 21093
South Florida Clinical Research Institute
Margate, Florida, 33063
SV Research LLC
Marion, Ohio, 43302
American Clinical Research, LLC
Marrero, Louisiana, 70072
West Jefferson Heart Clinic of Louisiana New Orleans Physician Services, Inc.
Marrero, Louisiana, 70072
Amici Clinical Research, LLC
Martinsville, New Jersey, 08836
Baptist Memorial Medical Group, Inc.
Memphis, Tennessee, 38119
The Green Clinic, PC
Memphis, Tennessee, 38119
Southwind Medical Specialists
Memphis, Tennessee, 38125
Solaris Clinical Research
Meridian, Idaho, 83646
ActivMed Practices and Research, Inc.
Methuen, Massachusetts, 01844
Future Clinical Research, Inc.
Miami, Florida, 33122
Advanced Clinical Research of Miami (ACROM) International
Miami, Florida, 33125
Project4Research, Inc
Miami, Florida, 33125
A & L Clinical Research
Miami, Florida, 33126
Finlay Medical Research
Miami, Florida, 33126
Pharmax Research Clinic, Inc.
Miami, Florida, 33126
Team Medical Research, Inc.
Miami, Florida, 33134
Team Medical Research
Miami, Florida, 33134
South Florida Research Center, Inc.
Miami, Florida, 33135
Florida Medical Center & Research, Inc.
Miami, Florida, 33142
Medical Research Center
Miami, Florida, 33144
Nuren Medical & Research Center
Miami, Florida, 33144
Doctors Research Institute
Miami, Florida, 33145
Advanced Pharma CR, LLC
Miami, Florida, 33147
Coast Research Institute
Miami, Florida, 33155
My Community Research Center, Inc.
Miami, Florida, 33155
Columbus Clinical Services LLC
Miami, Florida, 33165
Cardiovascular Research Center of South Florida
Miami, Florida, 33173
Research Institute of South Florida, Inc.
Miami, Florida, 33173
A & O Research Center, Inc.
Miami, Florida, 33174
BWell Research Center
Miami, Florida, 33175
Pharmacology International Research, Inc.
Miami, Florida, 33175
Poland83 sites
"""OSTEO-MEDIC"" s.c. Artur Racewicz, Jerzy Supronik"
Bialystok, Podlaskie Voivodeship, 15-351
Podlaski Osrodek Kardiologii Janusz Korecki
Bialystok, Podlaskie Voivodeship, 15-875
"OSTEO-MEDIC" s.c. Artur Racewicz, Jerzy Supronik
Bialystok, 15-351
Szpital Specjalistyczny w Brzozowie, Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza Oddzial
Brzozów, Podkarpackie Voivodeship, 36-200
NZOZ Vitamed
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-079
Nzoz Centrum Medyczne Kermed
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-231
NZOZ Vitamed -Ga¿aj I Cichomski sp.j
Bydgoszcz, 85-079
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Wojewodzki Szpital Specjalistyczny Nr 4 w Bytomiu,
Bytom, Silesian Voivodeship, 41-902
Wojewodzki Szpital Zespolony w Elblagu, Oddzial Kardiologiczny z Pododdzialem Kardiologii Inwazyjnej
Elblag, Warmian-Masurian Voivodeship, 82-300
Synexus Polska Sp. z o.o. Oddzial w Gdansku
Gdansk, Pomeranian Voivodeship, 80-382
Niepubliczny Zaklad Opieki Zdrowotnej Gdanskie Centrum Zdrowia, Poradnia Kardiologiczna
Gdansk, Pomeranian Voivodeship, 80-542
Centrum Badan Klinicznych Pi-House, Poradnia Diabetologiczna
Gdansk, Pomeranian Voivodeship, 80-546
Synexus Polska Sp. z o.o. Oddzial w Gdyni
Gdynia, Pomeranian Voivodeship, 81-384
NZOZ "PRO CORDIS" Sopockie Centrum Badan Kardiologicznych
Gdynia, Pomeranian Voivodeship, 81-423
Gabinet Kardiologiczno - lnternistyczny
Gdynia, Pomeranian Voivodeship, 81-472
Medica Pro Familia Sp. z o.o. Spolka Komandytowo Akcyjna, Oddzial w Gdyni
Gdynia, 81-338
Specjalistyczna Praktyka Lekarska Piotr Kubalski
Grudziądz, Kuyavian-Pomeranian Voivodeship, 86-300
Jeleniogorskie Centrum Chorob Serca, Przychodnia Kardiologiczna, Poradnia Kardiologiczna
Jelenia Góra, Lower Silesian Voivodeship, 58-506
Synexus Polska Sp. z o.o. Oddzial w Katowicach
Katowice, Masovian Voivodeship, 40-040
Bogna Gabrylewicz Andrzej Ochala Unimed s.c.
Katowice, Silesian Voivodeship, 40-083
Pro Familia Altera Poradnia Wielospecjalistyczna
Katowice, Silesian Voivodeship, 40-648
NZOZ Terapia Optima
Katowice, Silesian Voivodeship, 40-752
Prywatny Gabinet Lekarski Marianna Janion
Kielce, Świętokrzyskie Voivodeship, 25-315
Landa Specjalistyczne Gabinety Lekarskie
Krakow, Lesser Poland Voivodeship, 30-015
Szpital Specjalistyczny im. J. Dietla w Krakowie, Oddzial Kardiologii
Krakow, Lesser Poland Voivodeship, 31-121
Krakowski Szpital Specjalistyczny im. Jana Pawla II, Oddzial Szybkiej Diagnostyki
Krakow, Lesser Poland Voivodeship, 31-202
Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Spolka Jawna
Krakow, Lesser Poland Voivodeship, 31-216
CENTRUM MEDYCZNE A-Z Clinic
Krakow, Lesser Poland Voivodeship, 31-315
Krakowskie Centrum Medyczne Sp. z o.o.
Krakow, Lesser Poland Voivodeship, 31-501
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie,
Krakow, Lesser Poland Voivodeship, 31-531
Nzoz Gall-Med
Krakow, 30-053
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie,
Krakow, 31-501
SP ZOZ Szpital Uniwersytecki w Krakowie
Krakow, 31-501
NZOZ Centrum Zdrowia i Profilaktyki Dabie Sp. z.o.o.
Krakow, 31-567
INTERCARD Sp. z o.o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Krosnie
Krosno, Podkarpackie Voivodeship, 38400
SPZOZ Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Uniwersytetu Medycznego
Lodz, Iodzkie, 92-213
Specjalistyczny Osrodek Medycyny Wieku Dojrzalego
Lodz, 90-368
Gabinet Lekarski Malgorzata Saryusz-Wolska
Lodz, Łódź Voivodeship, 90-132
Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Sp. z o.o.
Lodz, Łódź Voivodeship, 90-368
"Prywatny Gabinet Kardiologiczny" Dr N.Med. Maciej Kosmider
Lodz, Łódź Voivodeship, 91-490
Clinical Best Solutions
Lublin, Lublin Voivodeship, 20-045
Optimamed Specjalistyczne Gabinety Lekarskie
Lublin, Lublin Voivodeship, 20-091
KO-MED Centra Kliniczne Lublin II
Lublin, Lublin Voivodeship, 20-362
"TWOJA PRZYCHODNIA" Sp. Z o.o
Lublin, 20-857
NeuroCor Banaszkiewicz, Kulaga, Ostrowska, Tomaszewski lekarze spolka partnerska
Myślenice, Lesser Poland Voivodeship, 32-400
NeuroCor Banaszkiewicz, Kulaga, Ostrowska, Tomaszewski lekarze spolka partnerska
Myślenice, 32-400
INTERCARD Sp. z. o. o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Nowym Targu
Nowy Targ, Lesser Poland Voivodeship, 34-400
Medicus w Opolu Sp z o. o.
Opole, 45-706
Specjalistyczny Osrodek Leczniczo-Badawczy Zbigniew Zegota
Ostróda, 14-100
Medicome Sp. z o.o.
Oświęcim, 32-600
Prywatny Gabinet Lekarski Dr n. med. Michal Ogorek
Piotrkow Trybunalski, Łódź Voivodeship, 97-300
Niepubliczny Zaklad Opieki Zdrowotnej Specjalistyczna Przychodnia Lekarska "MEDIKARD"
Płock, Masovian Voivodeship, 09-402
Synexus Polska Sp. z o.o Oddzial w Poznaniu
Poznan, Greater Poland Voivodeship, 60-702
Nzoz "Twoja Przychodnia"
Poznan, Greater Poland Voivodeship, 61-006
Centrum Zdrowia Metabolicznego Pawel Bogdanski
Poznan, 60-592
KO-MED Centra Kliniczne Pulawy
Puławy, Lublin Voivodeship, 24-100
Przychodnia Specjalistyczna Samodzielny Publiczny ZOZ w Rudzie Slaskiej, Poradnie Specjalistyczne,
Ruda Śląska, Silesian Voivodeship, 41-709
NZOZ Przychodnia Specjalistyczna Andrzej wittek Henryk Rudzki S.C.
Ruda Śląska, 41-709
EMED Centrum Uslug Medycznych Ewa Smialek
Rzeszów, Podkarpackie Voivodeship, 35205
Centrum Medyczne Ogrodowa Sp. z o.o.
Skierniewice, Łódź Voivodeship, 96-100
Centrum Medyczne "SOPMED" Sp. z o.o.
Sopot, Pomeranian Voivodeship, 81-756
Indywidualna Specjalistyczna Praktyka Lekarska Malgorzata Biedrzycka
Starogard Gdański, Pomeranian Voivodeship, 83-200
KO-MED Centra Kliniczne Staszow
Staszów, 28-200
Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M. Zabowka E. Zabowka
Tarnów, Lesser Poland Voivodeship, 33-100
Specjalistyczny Gabinet Lekarski Internistyczno-Kardiologiczny Boguslaw Derlaga
Tarnów, Lesser Poland Voivodeship, 33-100
Centrum Medyczne Piaski Filia Nr 9
Warsaw, Masovian Voivodeship, 01-875
Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych w Warszawie
Warsaw, Masovian Voivodeship, 02-507
CSK MSW w Warszawie, Klinika Kardiologii Zachowawczej i Nadcisnienia Tetniczego
Warsaw, Masovian Voivodeship, 02-507
Wojskowy Instytut Medyczny, Klinika Kardiologii i Chorob Wewnetrznych, Centralny Szpital Kliniczny
Warsaw, Masovian Voivodeship, 04-141
Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego
Warsaw, Masovian Voivodeship, 04-628
Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Sp. z o.o.
Warsaw, Masovian Voivodeship, 04-730
Synexus Polska Sp. z o.o. Oddzial w Warszawie
Warsaw, 01-192
Instytut Kardiologii, Ii Klinika Choroby WieCowej
Warsaw, 02-637
Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego
Warsaw, 04-628
Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala
Warsaw, 04-628
Specjalistyczne Gabinety Lekarskie "Medicor Plus" - Jerzy Kopaczewski
Włocławek, Kuyavian-Pomeranian Voivodeship, 87-800
NZOZ "Medyk"Sp. z o. o.
Wola, Silesian Voivodeship, 43-225
Synexus Polska Sp. z o.o. Oddzial we Wroclawiu
Wroclaw, Lower Silesian Voivodeship, 50-088
Wojewodzki Szpital Specjalistyczny we Wroclawiu, Osrodek Badawczo-Rozwojowy
Wroclaw, Lower Silesian Voivodeship, 51-124
Zdrowie s.c. Agnieszka i Donald Drozdz
Wroclaw, Lower Silesian Voivodeship, 51-314
Dobrostan Michal Bogacki
Wroclaw, 53-301
KO-MED Centra Kliniczne Zamosc
Zamość, Lublin Voivodeship, 22-400
Halina Serafin NZOZ Centrum Medyczne SERAFIN-MED
Żarów, Lower Silesian Voivodeship, 58-130
Netherlands74 sites
Noordwest Ziekenhuisgroep
Alkmaar, 1815 JD
EB Flevoresearch
Almere Stad, 1311 RL
Meander Medical Center
Amersfoort, 3813 TZ
Meander Medisch Centrum
Amersfoort, 3813 TZ
Amstelland Hospital
Amstelveen, 1186 AM
Bovenij Ziekenhuis
Amsterdam, 1034 CS
OLVG, locatie West
Amsterdam, 1061 AE
VU University Medical Center
Amsterdam, 1081 HV
Onze Lieve Vrouwe Gasthuis
Amsterdam, 1091 AC
Academic Medical Center
Amsterdam, 1105 AZ
Gelre Hospitals
Apeldoorn, 7334 DZ
Rode Kruis Ziekenhuis
Beverwijk, 1942 LE
Tergooi Ziekenhuis
Blaricum, 1261 AN
Andro Medical Research B.V.
Breda, 4811 SW
Amphia Ziekenhuis
Breda, 4818 CK
Reinier de Graaf Ziekenhuis
Delft, 2625 AD
Deventer Ziekenhuis
Deventer, 7416SE
Van Weel Bethesda Hospital
Dirksland, 3247 BW
Slingeland Ziekenhuis
Doetinchem, 7009 BL
Albert Schweitzer Ziekenhuis-Albert Schweitzer Hospital
Dordrecht, 3318 AT
Ziekenhuis Gelderse Vallei
Ede, 6716 RP
Andromed Eindhoven
Eindhoven, 5611 NV
Heartcentre Catharina Hospital
Eindhoven, 5623 EJ
Medisch Spectrum Twente
Enschede, 7512 KZ
Beatrix Hospital
Gorinchem, 4204 AA
Beatrix Ziekenhuis
Gorinchem, 4204 AA
Groene Hart Ziekenhuis
Gouda, 2803 HH
University Medical Center Groningen
Groningen, 9713 GZ
Martini Ziekenhuis
Groningen, 9728 NT
Spaarne Gasthuis
Haarlem, 2035 RC
Ropcke Zweers Hospital
Hardenberg, 7772 SE
St. Jansdal Ziekenhuis
Harderwijk, 3844 DG
Tjongerschans Ziekenhuis
Heerenveen, Provincie Friesland, 8441 PW
Zuyderland Medisch Centrum
Heerlen, 6419 PC
Zuyderland
Heerlen, 6419PC
Treant Zorggroep, location Bethesda
Hoogeveen, 7909 AA
Vascular Research Centre
Hoorn, 1624 NP
Quality Care Research
Kloosterhaar, 7694 AC
Medisch Centrum Leeuwarden
Leeuwarden, 8934 AD
Leiden University Medical Center
Leiden, 2333 ZA
Alrijne Ziekenhuis
Leiden, 2334 CK
Alrijne Ziekenhuis
Leiderdorp, 2353 GA
GCM Maarssenbroek
Maarssen, 3607 KN
Maastricht University Medical Center
Maastricht, 6229 HX
Isala Diaconessenhuis
Meppel, 7943 KA
St Antonius Hospital
Nieuwegein, 3435 CM
Radboud University Nijmegen Medical Centre
Nijmegen, 6525 GA
Canisius Wilhelmina Ziekenhuis
Nijmegen, 6532 SZ
Waterland Hospital
Purmerend, 1441 RN
St. Franciscus Gasthuis
Rotterdam, South Holland, 3045 PM
Andro Medical Research B.V.
Rotterdam, 3021 HC
Hedramed
Rotterdam, 3037 AN
Rotterdam Research Institute
Rotterdam, 3039 BD
Ikazia Ziekenhuis
Rotterdam, 3083AN
Zuyderland MC
Sittard-Geleen, Limburg, 6162 BG
D&A Research and Genetics
Sneek, 8601 ZR
Hedramed
The Hague, 2526 HW
Hagaziekenhuis
The Hague, 2545 CH
Bronovo Ziekenhuis
The Hague, 2597 AX
Ziekenhuis Rivierenland
Tiel, 4002 WP
Elisabeth-TweeSteden Ziekenhuis (previously named St. Elisabeth Ziekenhuis)
Tilburg, 5022 GC
St. Elisabeth Ziekenhuis
Tilburg, 5022 GC
Elisabeth TweeSteden Ziekenhuis (ETZ)
Tilburg, 5042 AD
Bernhoven Ziekenhuis
Uden, 5406 PT
EB Utrecht
Utrecht, 3511 NH
Universitair Medisch Centrum (UMC) Utrecht - Locatie AZU
Utrecht, 3584 CX
University Medical Center Utrecht
Utrecht, 3584 CX
Maxima Medisch Centrum
Veldhoven, 5504 DB
VieCuri Medisch Centrum
Venlo, 5912 BL
Twee Steden Ziekenhuis
Waalwijk, 5141 BM
Het Lange Land Ziekenhuis
Zoetermeer, South Holland, 2725 NA
Klinisch Onderzoek Praktijk Zoetermeer
Zoetermeer, 2712 AB
Albert Schweitzer Hospital
Zwijndrecht, 3331 LZ
Isala
Zwolle, Overijssel, 8025 AB
Germany70 sites
Klinikum Altenburger Land Gmbh
Altenburg, 04600
Zentralklinik Bad Berka GmbH
Bad Berka, 99437
Forschungszentrum Dr. med Irma Schoell
Bad Homburg, 61348
Universitaets Herzzentrum Freiburg Bad Krozingen
Bad Krozingen, Baden-Wurttemberg, 79189
Institut fuer Klinische Forschung und Entwicklung(IKFE) Berlin GmbH
Berlin, 10115
Klinische Forschung Berlin-Mitte GmbH
Berlin, 10117
POLIKUM Institut GmbH
Berlin, 12157
DRK Kliniken Kopenick, Zentrum Klinische Forschung
Berlin, 12559
Berlin Research Centre-Synexus Clinical Research GmbH
Berlin, 12627
Synexus Clinical Research GmbH
Berlin, 12627
Deutsches Herzzentrum Berlin
Berlin, 13353
Medizinisches Versorgungszentrum am Bahnhof Spandau
Berlin, 13597
Klinikum Bielefeld
Bielefeld, 33604
Bochum Research Centre-Synexus Clinical Research GmbH
Bochum, 44787
MediClin Reha-Zentrum Spreewald
Burg, 03096
Klinikum Coburg
Coburg, 96450
Zentrum fuer klinische Forschung
Cologne, 51069
HELIOS Amper-Klinikum Dachau
Dachau, 85221
Kardiologische Praxisgemeinschaft
Dortmund, 44137
St. Johannes-Hospital
Dortmund, 44137
Gemeinschaftspraxis fuer Kardiologie Dres. Med. Willgeroth/Wetzel
Dortmund, 44141
Klinsche Forschung Dresden GmbH
Dresden, 01069
Praxis Dr. med. Christoph Axthelm
Dresden, 01277
GWT-TUD GmbH, Studienzentrum Professor Hanefeld
Dresden, 01307
Gemeinschaftspraxis Dr. Hagemann/Breiderhoff/Durfeld
Essen, 45355
Medizentrum Essen Borbeck
Essen, 45355
Studienzentrum
Essen, 45355
Gemeinschaftspraxis Dres. Dirk Weber, Ulrich Weber, Heiner Saueressig, Birte Turner und Georg
Essen, 45359
Schwerpunktpraxis Dr. Luedemann fuer Diabetes Gefaess- und Ernaehrungsmedizin
Falkensee, 14612
Clinphenomics Gmbh & Co Kg, Studienzentrum
Frankfurt, 60 594
Synexus Clinical research GmbH
Frankfurt, 60596
IKF Institut fuer klinische Forschung Frankfurt
Frankfurt am Main, 60596
Gemeinschaftspraxis im Altstadt Carree
Fulda, Hesse, 36037
Klinik und Poliklinik fuer Innere Medizin B-Kardiologie, Angiologie, Pulmologie, Internistische
Greifswald, 17475
Cardiologicum Hamburg
Hamburg, 22041
Praxis Dr. med Cornelia Brauer
Hamburg, 22415
Klinische Forschung Hannover-Mitte GmbH
Hanover, 30159
Medizinische Universtatsklinik Heidelberg
Heidelberg, Baden-Wurttemberg, 69120
Universitatsklinikum des Saarlandes Klinik fur Innere Medizin III
Homburgsaar, 66421
Praxis Dr. Heister
Kamp-Lintfort, 47475
Studienzentrum Dr. Appel
Kassel, 34121
Gemeinschaftspraxis Dr. Klein / Minnich
Künzing, 94550
Klinik fur Innere Medizin, Kardiologie und Angiologie MediClin Herzzentrum Lahr/Baden.
Lahr, 77933
Synexus Clinical research GmbH
Leipzig, 04103
Synexus Leipzig Clinical Research Centre
Leipzig, 04103
Polikum Institut Leipzig GmbH
Leipzig, 04109
Gemeinschaftspraxis Dr. med. Heidrun Taeschner und Dr. med. Susanne Bonigut
Leipzig, 04249
Maerkische Kliniken GmbH, Klinikum Luedenscheid, Innere III
Lüdenscheid, 58515
Klinikum Lunen, St. Marienhospital
Lünen, 44534
SMO.MD GmbH - Zentrum für klinische Studien
Magdeburg, 39120
SMO.MD GmbH, Zentrum fuer klinische Studien Site Management and Clinical Research Unit
Magdeburg, 39120
Pfuetzner Science & Health Institute-Gmbh
Mainz, 55116
Ze:ro Arztpraxen
Mannheim, Baden-Wurttemberg, 68165
Klinikum Der Universitat Munchen
München, 80336
Klinikum fuer Herz- & Kreislauferkrankungen
München, 80636
Staedtisches Klinikum Muenchen GmbH
Munich, 81737
Zentrum Klinische Studien Neuwied (ZKSN)
Neuwied, Rhineland-Palatinate, 56564
Kardiologische Praxis Northeim
Northeim, 37154
Gemeinschaftspraxis Drs Haggenmiller/Jeserich, Kardiologie, Angiologie, Innere Medizin
Nuremberg, 90402
Allgemeinmedizinisch-Internistische Praxisgemeinschaft
Offenbach, 63071
Praxis Dres. Med Naudts und Nowack
Rodgau, 63110
Klinik am See Rehabilitationszentrum fur Innere Medizin
Rüdersdorf, 15562
Gemeinschaftspraxis Schwabenheim
Schwabenheim, Rhineland-Palatinate, 55270
Klinische Forschung Schwerin GmbH
Schwerin, Mecklenburg-Vorpommern, 19055
Kardiologische Gemeinschaftspraxis Dres Med. Gerke/Burger
Soest, 59494
Praxisgemeinschaft Stuhr-Brinkum
Stuhr-Brinkum, 28816
Robert-Bosch-Krankenhaus
Stuttgart, 70376
Josephs-Hospital Warendorf Med. Klinik II, Kardiologie/Angiologie
Warendorf, 48231
Kardiologische Praxis
Wermsdorf, 04779
ForschungszentrumRuhr KliFoCenter GmbH
Witten, 58455
Canada67 sites
LMC Diabetes & Endocrinology (Brampton)
Brampton, Ontario, L6S 0C9
Aviva Clinical Trial Group Inc.
Burlington, Ontario, L7M 4Y1
JBN Medical Diagnostic Services Inc.
Burlington, Ontario, L7M 4Y1
Philippe R. Beaudry Medicine Professional Corporation
Burlington, Ontario, L7R 4E2
LMC Diabetes & Endocrinology (Calgary)
Calgary, Alberta, T2H 2G4
Foothills Hospital/University of Calgary
Calgary, Alberta, T2N 4Z6
Nanji Professional Corporation
Calgary, Alberta, T2V 4J2
Cambridge Cardiac Care Centre
Cambridge, Ontario, N1R 6V6
Vizel Cardiac Research - Saul Vizel Professional Medicine Corporation
Cambridge, Ontario, N1R 7R1
Ecogene-21
Chicoutimi, Quebec, G7H 7K9
Q & T Research Chicoutimi
Chicoutimi, Quebec, G7H 7Y8
Moran Medical Centre
Collingwood, Ontario, L9Y 1W3
C & L Research
Fort Erie, Ontario, L2A 1Z3
Q&T Recherche Outaouais Inc.
Gatineau, Quebec, J8Y 6S8
Brian Y.L. Wong Medicine Professional Corporation
Greater Sudbury, Ontario, P3E 2N8
Parkdale Medical Centre
Hamilton, Ontario, L8K 3P3
The Medical Arts Health Research Group
Kelowna, British Columbia, V1Y 1V6
Kelowna Cardiology Associates
Kelowna, British Columbia, VlY 1V6
Stroke Prevention & Atherosclerosis Research Centre (SPARC)
London, Ontario, N6G 2V2
Western University - WCPHFM
London, Ontario, N6G2Ml
LMC Diabetes & Endocrinology (Markham)
Markham, Ontario, L6B 0P9
Omnispec Recherche Clinique Inc.
Mirabel, Quebec, J7J 2K8
G.A. Research Associates Ltd.
Moncton, New Brunswick, E1G 1A7
Montreal Heart Institute
Montreal, Quebec, H1T 1C8
Diex Research Montreal, Inc.
Montreal, Quebec, H2Y 1S1
Newmarket Cardiology Research Group
Newmarket, Ontario, L3Y 8C3
LMC Clinical Research Inc. (Oakville)
Oakville, Ontario, L6M 1M1
The Office of Dr. James Cha
Oshawa, Ontario, L1J 2K1
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2
Recherche Clinique Sigma inc
Québec, Quebec, G1G 3Y8
Clinique des maladies lipidiques de Quebec
Québec, Quebec, G1V 4W2
Cardiology Research Associates of New Brunswick
Saint John, New Brunswick, E2L 4L2
Centre integre de sante et de services sociaux de Lanaudiere (CISSSL)
Saint-Charles-Borromée, Quebec, J6E 6J2
CISSS des Laurentides-Point de Service de St-Jerome- Comite d'ethique de la recherche
Saint-Jérôme, Quebec, J7Z 5T3
St-Jerome Medical Research Inc.
Saint-Jérôme, Quebec, J7Z 5T3
LMC Clinical Research Inc. (Montreal)
Saint-Laurent, Quebec, H4T 1Z9
London Road Diagnostic Clinic and Medical Centre
Sarnia, Ontario, N7T 4X3
Sarnia Institute of Clinical Research
Sarnia, Ontario, N7T 4X3
Scarborough Cardiology Research Associates Inc.
Scarborough Village, Ontario, M1E 5E9
Centre Hospitalier Universitaire de Sherbrooke - Hotel-Dieu
Sherbrooke, Quebec, J1G 2E8
Canadian Centre for Research on Diabetes
Smiths Falls, Ontario, K7A 4W8
Centre Integre de Sante et de services sociaux de Chaudiere-Appalaches (CISSA-CA) -
St-Georges, Beauce, Quebec, G5Y 4T8
Health Sciences Centre
St. John's, NF, A1B 3V6
Health Science Centre
St. John's, NF, A1B3V6
Dr. Raymond Dong Inc.
Surrey, British Columbia, V3V 0C6
Dr. Richard Bon Inc. & Dr. Adam Yeung Inc.
Surrey, British Columbia, V3V 0C6
Dr. Stephen S. Cheung Inc.
Surrey, British Columbia, V3V 0C6
SMH Cardiology Clinical Trials
Surrey, British Columbia, V3V 0C6
Dr. Dante E. Manyari Inc.
Surrey, British Columbia, V3V 1N1
Dr. Stephanie Au, Inc.
Surrey, British Columbia, V3V 1N1
Dr. Stephen Pearce Inc. & Dr. Peter K.H. Tan Inc.
Surrey, British Columbia, V3V 1N1
SMH Cardiology Clinical Trials Inc
Surrey, British Columbia, V3V 1N1
Dr. Adam Yeung Inc.
Surrey, British Columbia, V3V OC6
Dr. Michael Kanakos Inc.
Surrey, British Columbia, V3V OC6
Dr. Stephen S. Cheung Inc.
Surrey, British Columbia, V3VOC6
Dr. Kapil M. Bhagirath Medical Services Corporation
Surrey, British Columbia, V3W 3C3
LMC Diabetes & Endocrinology (Thornhill)
Thornhill, Ontario, L4J 8L7
JJ Dig Research LTD
Toronto, Ontario, M3J 1N2
Canadian Phase Onward, Inc.
Toronto, Ontario, M3J 2C5
LMC Diabetes & Endocrinology (Bayview)
Toronto, Ontario, M4G 3E8
Dr. Anil K. Gupta Medicine Professional Corporation
Toronto, Ontario, M9V 4B4
C.I.C. Mauricie Inc.
Trois-Rivières, Quebec, G8T 7A1
Victoria Heart Institute Foundation
Victoria, British Columbia, V8R 4R2
Discovery Clinical Services Ltd.
Victoria, British Columbia, V8T 5G4
Dr. Mohan Babapulle Medicine Professional Cooperation
Waterloo, Ontario, N2T 0C1
Dr. Louis Yao, MD Office of
Weston, Ontario, M9N 1W4
St. Boniface Hospital
Winnipeg, Manitoba, R2H 2A6
Spain67 sites
Gerencia de Gestion integrada de A Coruna
A Coruña, 15006
Complejo Hospitalario Universitario de Albacete
Albacete, 02006
Hospital Virgen De Los Lirios
Alcoy, Alicante, 03804
Hospital Universitario San Juan de Alicante
Alicante, Valencia, 03550
Hospital General Universitario de Alicante; Servicio Cardiologia
Alicante, 03010
Hospital Virgen del Mar
Almería, 04120
Hospital Universitario de Cruces
Barakaldo, Basque Country, 48903
Parc de Salut mar ¿ Hospital del Mar
Barcelona, 08003
Parc de Salut Mar- Hospital del Mar
Barcelona, 08003
Centre Teknon
Barcelona, 08022
EAP Sardenya
Barcelona, 08025
Hospital de la Santa Creu i Sant Pau
Barcelona, 08025
Hospital Universitari Vall d'Hebron
Barcelona, 08035
CAP Centelles
Barcelona, 08540
CAP Amadeu Torner
Barcelona, 08902
Hospital Universitario de Bellvitge
Barcelona, 08907
Fundacio Hospital de I'Esperit Sant
Barcelona, 08923
Hospital Universitario Reina Sofia
Córdoba, 14004
CAP Disset De Setembre (Sant Cosme I Sant Damia)
el Prat de Llobregat, Barcelona/cataluna, 08820
Hospital Arquitecto Marcide
Ferrol, LA Coruna, 15405
Complexo Hospitalario Universitario Arquitecto Marcide-Profesor Novoa Santos De Ferrol
Ferrol, 15401
Hospital De Figueres
Figueres, Girona-catalonia, 17600
Hospital Universitario San Cecilio
Granada, 18012
Hospital Universitario Virgen de las Nieves (HUVN)
Granada, 18014
Hospital Comarcal d'Inca
Inca, Balearic Islands, 07300
Cap Florida
L'Hospitalet de Llobregat, Barcelona-cataluna, 08905
Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, Barcelona, 08907
Hospital Universitari Arnau de Vilanova (HUAV)
Lleida, 25198
Hospital Universitari Arnau de Vilanova
Lleida, 25198
Pharmacy - Hospital Universitari Arnau de Vilanova (HUAV)
Lleida, 25198
Hospital Universitario Lucus Augusti
Lugo, 27003
Hospital Universitario de La Princesa
Madrid, 28006
Hospital General Universitario Gregorio Maranon
Madrid, 28007
Hospital Carlos III
Madrid, 28029
Hospital Universitario Ramon y Cajal
Madrid, 28034
Fundacion Jimenez Diaz
Madrid, 28040
Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040
Hospital Universitario La Paz; Unidad Metabolico-Vascular
Madrid, 28046
Hospital Universitario Infanta Sofía
Madrid, 28702
Carretera Alcala-Meco s/n
Madrid, 28805
H. U. Principe de Asturias
Madrid, 28805
Hospital Hospital Universitario Puerta de Hierro - Majadahonda
Majadahonda, Madrid, 28222
Hospital Regional Universitario de Malaga
Málaga, Andalusia, 29010
Hospital Universitario Virgen de la Victoria. CE San Jose Obrero
Málaga, 29006
Hospital Regional Universitario de Malaga
Málaga, 29009
Hospital Universitario Virgen De La Victoria
Málaga, 29010
Hospital General Universitario Morales Meseguer
Murcia, 30008
Centro de Salud El Cristo
Oviedo, Principality of Asturias, 33006
Centro Salud Paulino Prieto
Oviedo, Principality of Asturias, 33009
Albera Salut
Peralada, Gerona, 17491
Hospital Universitario Quiron Madrid
Pozuelo de Alarcón, Madrid, 28223
Hospital General De Requena
Requena, Valencia, 46340
Hospital Universitario Sant Joan de Reus
Reus, Tarragona, 43204
Hospital Universitario Sant Joan de Reus
Reus (Tarragona), 43204
Hospital Santa Caterina
Salt, Girona, Girona, 17190
CAP La Mina
Sant Adrià de Besòs, Barcelona, 08930
Hospital Universitario Marques De Valdecilla
Santander, Cantabria, 39008
Hospital Clinico Universitario de Santiago de Compostela
Santiago de Compostela, A Coruna, 15706
Hospital Universitario Virgen del Rocio
Seville, Andalusia, 41013
Clinica Nuevas Tecnologias En Diabetes Y Endocrinologia
Seville, 41003
Hospital Universitario Virgen Macarena
Seville, 41009
Hospital Universitario Virgen de Valme
Seville, 41014
Hospital Universitari de Tarragona Joan XXIII
Tarragona, Catalonia, 43007
CAP Muralles
Tarragona, 43002
Hospital General Universitario de Valencia
Valencia, 46014
EAP Vic
Vic, Barcelona, 08500
Hospital Clinico Universitario Miguel Servet; Medicina Interna
Zaragoza, 50009
Russia61 sites
Municipal Budgetary State Healthcare Institution "City Clinical Hospital #6"
Chelyabinsk, 454047
Non-State Institution of Healthcare
Chelyabinsk, 454092
State Budgetary Healthcare Institution ¿Region Clinical Hospital #3¿
Chelyabinsk, 454136
Regional Budgetary Healthcare Institution "Cardiology Dispensary"
Ivanovo, 153012
State Budgetary Institution of Healthcare of Kaluga Region "Kaluga Regional Hospital"
Kaluga, 428007
FSBEI of HE Kazan State Medical University on the base of SBHI Clinical Hospital No.2
Kazan', Tatarstan Republic, 420033
Federal State Budgetary Educational Institution of Higher Education "Kazan State Medical University"
Kazan', 420012
State Autonomous Healthcare Institution "Republic Clinical Hospital"
Kazan', 420064
"SAHI of Kemerovo ""Regional Clinical Hospital of Emergency Medical Care n.a. M.A Podgorbunsky """
Kemerovo, 650000
Municipal Budgetary Institution of Healthcare Municipal Clinical Hospital #3 n.a. M.A. Podgorbunsky
Kemerovo, 650000
FSBI "Research institute of complex problems of cardio-vascular diseases" of
Kemerovo, 650002
FSHI "Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia across
Kemerovo, 650099
Kirov Regional State Budgetary Healthcare Institution "Kirov City Clinical Hospital #1"
Kirov, 610014
State Budgetary Healthcare Institution "Research Institution - Regional Clinical Hospital #1
Krasnodar, Krasnodarskiy Kray, 350086
Regional Budgetary Healthcare Institution "Kursk City Clinical Emergency Hospital"
Kursk, 305035
State Budgetary Healthcare Institution of Moscow Region "Lubertsy Regional Hospital #2"
Lubertsy, Moscow Oblast, 140006
Non-State Institution of Healthcare "Central Clinical Hospital #6 OAO "RZhD"
Moscow, 109388
SBHI Moscow city "City Clinical Hospital #15 n.a. O.M. Filatova" of Moscow Healthcare Department
Moscow, 111539
Federal State Budgetary Institution "Central Clinical Hospital with Polyclinic"
Moscow, 121359
"Federal State Budgetary Institution "Russian Cardiology Research And Production Complex" Of
Moscow, 121552
Moscow State Healthcare Institution "City clinical hospital n.a. S.P.Botkin"
Moscow, 125284
State Budget Institution of Healthcare (SBIH) of Moscow "City Clinical Hospital #81
Moscow, 127644
Federal State Budget Institution "Out-patient Clinic #3" of Russian Federation, President's
Moscow, 129090
State Regional Budgetary Healthcare Institution
Murmansk, 183047
State Budgetary Healthcare Institution of Nizhegorodskaya Region
Nizhny Novgorod, 603076
Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine"
Novosibirsk, 630089
"Reafan" LLC
Novosibirsk, 630099
Municipal Budgetary Institution of Healthcare of Novosibirsk
Novosibirsk, 630102
State Budgetary Institution of Healthcare of Novosibirsk region City Clinical Hospital of Emergency
Novosibirsk, 630102
State Budgetary Healthcare Institution (SBHI) N.N. Burdenko Regional Clinical Hospital of Penza
Penza, 440026
SBHI of Saint-Petersburg "City Hospital # 38 n.a. N.A. Semashko"
Pushkin, 196601
State Budgetary Educational Institution Of Higher Professional Education
Rostov-on-Don, 344022
State Budgetary Educational Institution of Higher Professional Education
Rostov-on-Don, 344068
State Budgetary Institution "Ryazan Regional Clinical Hospital"
Ryazan, 390039
1st Pavlov State Medical University of St. Petersburg
Saint Petersburg, Sankt-Peterburg, 197022
Saint Petersburg State Budgetary Institution of Healthcare
Saint Petersburg, Sestroretsk, 197706
Saint-Petersburg State Budgetary Institution of Healthcare "City Hospital #23"
Saint Petersburg, 192148
Saint-Petersburg State Budgetary Healthcare Institution "City Alexandrovskaya Hospital"
Saint Petersburg, 193312
Limited Liability Company "Reavita"
Saint Petersburg, 194354
LLC "Institution of medical studies"
Saint Petersburg, 196084
Saint-Petersburg State Budgetary Institution of Healthcare "City Hospital #26"
Saint Petersburg, 196247
Federal State Budgetary Educational Institution of Higher Education "Academician I.P. Pavlov First
Saint Petersburg, 197022
SBEI of HPE "First Pavlov State Medical University of St. Petersburg" of the MoH of the RF
Saint Petersburg, 197022
Federal State Budgetary Institution "Advisory Diagnostic Center and Polyclinic"
Saint Petersburg, 197110
Federal State Budgetary Institution "Federal Almazov Medical Research Centre" of
Saint Petersburg, 197341
Saint-Petersburg State Budgetary Healthcare Institution "City Hospital #15"
Saint Petersburg, 198205
Limited Liability Company International Medical Centre SOGAZ
Saint-Petersberg, 191186
State Budgetary Healthcare Institution "Samara Regional Clinical Cardiology Dispensary"
Samara, 443070
MHI "City Clinical Hospital 12"of the Healthcare Committee of
Saratov, 410039
State Institution of Healthcare "Regional Clinical Hospital"
Saratov, 410053
Tyumen Cardiology Research Center-branch of the Tomsk NRMC
Tomsk, 634009
State Budgetary Educational Institution of Highest Professional Education
Tomsk, 634050
Federal State Budgetary Institution of Healthcare Hospital of Russian Academy of Sciences
Troitsk, Moscow Oblast, 142190
State Autonomous Healthcare Institution of Tyumen region "Scientific-Practical Medical Center"
Tyumen, 625000
"Tyumen Cardiology Center" Affiliate of the FSBSI "Scientific and Research Institution of Cardiology
Tyumen, 625026
State Autonomous Healthcare Institution of Yaroslavl region Clinical Emergency Hospital n.a..N.V.So
Yaroslavl, 150003
State Autonomous Healthcare Institution of Yaroslavl Region
Yaroslavl, 150003
FSBEI of HE "Yaroslavl State Medical University" MH of the Russian Federation based on Clinical
Yaroslavl, 150010
State Budgetary Healthcare Institution of Yaroslavl Region "Clinical Hospital No. 10"
Yaroslavl, 150023
State Healthcare Institution of Yaroslavl Region "Clinical Hospital #8"
Yaroslavl, 150030
Municipal Autonomous Institution "City Clinical Hospital #14"
Yekaterinburg, 620039
United Kingdom49 sites
The Crouch Oak Family Practice
Addlestone, Surrey, KT15 2BH
Royal Free London NHS Foundation Trust
Barnet, EN5 3DJ
Synexus Midlands Clinical Research Centre
Birmingham, WEST Midlands, B15 2SQ
City Hospital
Birmingham, WEST Midlands, B18 7QH
Laurie Pike Health Centre
Birmingham, B6 6BB
Heart of England NHS Foundation Trust, Dept. of Clinical Biochemistry & Immunology
Birmingham, B9 5SS
Bolton NHS Foundation Trust
Bolton, Lancashire, BL4 0JR
Ely Bridge Surgery
Cardiff, Wales, CF5 4AD
Synexus Wales Clinical Research Centre
Cardiff, CF14 5GJ
Ashgate Medical Practice
Chesterfield, S404AA
Synexus Lancashire Clinical Research Centre
Chorley, Lancashire, PR7 7NA
South Axholme Practice
Doncaster, South Yorkshire, DN9 2HY
Little Common Surgery
East Sussex, TN39 4SP
Sea Road Surgery
East Sussex, TN40 1JJ
Staploe Medical Centre
Ely, CB7 5JD
Medway Maritime Hospital
Gillingham, KENT, ME7 5NY
Synexus Scotland Clinical Research Centre
Glasgow, Lanarkshire, G20 0SP
McGlone Practice - Ballieston Health Centre
Glasgow, G69 7AD
The Queen Elizabeth University Hospital- NHS Greater Glasgow and Clyde
Glosgow, G51 4TF
Synexus North East Clinical Research Centre - Hexham General Hospital
Hexham, Northumberland, NE46 1QJ
Burbage Surgery
Hinckley, LE10 2SE
Layton Medical Centre
Layton, Blackpool, Lancashire, FY3 7EN
Synexus Merseyside Clinical Research Centre
Liverpool, Merseyside, L22 0LG
The Royal Liverpool and Broadgreen -University Hospitals NHS
Liverpool, L7 8XP
Prince Philip Hospital
Llanelli, WEST Wales, SF14 8QF
Barts Health NHS Trust
London, EC1M 6BQ
Royal Free Hospital
London, NW3 2QG
Peart-Rose Research Unit, Hammersmith Hospital, Imperial College NHS Trust
London, W12 OHS
Synexus Manchester Clinical Research Centre-Manchester Science Park
Manchester, Greater Manchester, M15 6SX
Central Manchester University Hospitals NHS Foundation Trust
Manchester, South Yorkshire, M13 9WL
The Red Porto cabin, The James Cook University Hospital
Middlesbrough, TS4 3BW
St Mary's Hospital
Newport, PO30 5TG
Royal Oldham Hospital
Oldham, Greater Manchester, OL1 2JH
Peterborough and Stamford Hospitals NHS Foundation Trust
Peterborough, Cambridgeshire, PE3 9GZ
Wansford And Kings Cliffe Practice
Peterborough, PE8 6PL
Southern Health & Social Care Trust, Craigavon Area Hospital
Portadown, Northern Ireland, BT63 5QQ
Synexus Thames Valley Clinical Research Centre
Reading, Berkshire, RG2 0TG
Queens Hospital
Romford, Essex, RM7 0AG
Rothwell and Desborough Healthcare Group
Rothwell, Northants, NN14 6JQ
Salford Royal NHS Foundation Trust
Salford, Greater Manchester, M6 8HD
Brannel Surgery
St Austell, Cornwall, PL26 7RL
Lister Hospital
Stevenage, Hertfordshire, SG1 4AB
Abertawe Bro Morgannwg University Local Health Board Joint
Swansea, SA2 8PP
Albany House Medical Centre
Wellingborough, Northants, NN84RW
Queen Elizabeth II Hospital, East and North Hertfordshire NHS Trust
Welwyn Garden City, Hertfordshire, AL7 4HQ
Whitby Group Practice
Whitby, North Yorkshire, YO21 1SD
Western Sussex Hosptials NHS Trust
Worthing, BN11 2DH
York Medical Group
York, YO30 6AE
Strensall Healthcare Centre
York, YO32 5UA
Argentina43 sites
Instituto de Investigaciones Clinicas Bahia Blanca
Bahía Blanca, Buenos Aires, B8000FTD
Hospital Italiano Regional del Sur
Bahía Blanca, Buenos Aires, B8001HXM
Universidad Maimonides
Buenos Aires, C1405BCK
Centro de Investigacion: AXISMED S.R.L.
Buenos Aires, C1430CKE
STAT Research S.A.
C.a.b.a, Buenos Aires F.D., C1023AAB
Consultorios Asociados de Endocrinologia e Investigacion Clinica Aplicada
C.a.b.a, C.a.b.a., C1425AGC
CIPREC - Centro de Investigacion y Prevencion Cardiovascular S.A.
C.a.b.a., Buenos Aires, C1119ACN
Hospital Britanico De Buenos Aires
Ciudad Autonoma de B. Aires, Buenos Aires, C1280AEB
Cicemo - Consultorio de Investigaciones Clinicas E.M.O. S.R.L.
Ciudad Autonoma de B. Aires, C1405BUB
Instituto Cardiovascular De Buenos Aires
Ciudad Autonoma de B. Aires, C1428ART
Investigaciones Medicas IMOBA S.R.L.
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1179AAB
CEDIC - Consultorios Medicos
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1425DES
IMEP Instituto Medico Elsa Perez
Ciudadela, PCIA de Buenos Aires, 1702
ILAIM Instituto Latinoamericano de Investigaciones Medicas
Córdoba, X5000BNB
Clinico Chutro SRL
Córdoba, X5000EPU
Centro de Investigaciones Clinicas "Instituto del Corazon"
Córdoba, X5000EVQ
Clinica Privada Colombo
Córdoba, x5002AOQ
Instituto Medico DAMIC S.R.L.
Córdoba, X5003DCE
Centro Medico Luquez
Córdoba, X5006IKK
IPAC Caraffa
Córdoba, X5008KKF
Clinica Coronel Suarez S.A.
Coronel Suárez, Buenos Aires, B7540GHD
Instituto de Cardiologia de Corrientes "Juana Fca. Cabral"
Corrientes, 3400
Hospital de Alta Complejidad "Pte. Juan Domingo Peron"
Formosa, PCIA de Formosa, 3600
CIPADI Centro Integral de Prevencion y Atencion en Diabetes
Godoy Cruz, Mendoza Province, M5501ARP
Framingham Centro Medico
La Plata, Buenos Aires, B1902COS
CIMeL CHAHIN CHAHIN S.A.
Lanús Este, Buenos Aires, B1824KAJ
Instituto de Investigaciones Clinicas Mar del Plata
Mar del Plata, Buenos Aires, B7600FZN
Hospital Central de Mendoza
Mendoza, 5500
Instituto Medico Aguero
Morón, PCIA de Buenos Aires, B1708CGU
DIM Clinica Privada
Ramos Mejía, Buenos Aires, B1704ETD
Cordis - Instituto del Corazon
Resistencia, PCIA de Chaco, H3500CDM
Instituto de Hematologia y Medicina Clinica "Dr. Ruben A. Davoli"
Rosario, Pcia. de Santa FE, S2000CFK
Instituto Medico Ceniclar - Central De Investigaciones Clinicas Argentina - Sanatorio De La Mujer
Rosario, Santa Fe Province, S2000QID
Cordis S.A.
Salta, 4400
Centro Cardiovascular Salta
Salta, A4406BPF
Instituto Cardiovascular San Luis A.E.
San Luis, D5702JRS
Centro Modelo de Cardiologia
San Miguel de Tucumán, PCIA de Tucuman, T4000IFL
Centro Medico CCBR Tucuman
San Miguel de Tucumán, Tucumán Province, T4000IAF
Hospital Provincial Dr. Jose Maria Cullen
Santa Fe, PCIA de Santa FE, S3000EOZ
Centro De Investigaciones Clinicas Del Litoral S.R.L.
Santa Fe, PCIA de Santa FE, S3000FWO
Cedir S.A - Centro De Diagnostico Y Rehabilitacion S.A.
Santa Fe, PCIA de Santa FE, S3004CVS
Clinica Privada de Especialidades Medicas
Villa María, Córdoba Province, 5901
Instituto de Investigaciones Clinicas Zarate
Zárate, Buenos Aires, B2800DGH
Slovakia42 sites
Stredoslovensky ustav srdcovych a cievnych chorob a.s.
Banská Bystrica, 974 01
Fakultna nemocnica F. D. Roosevelta
Banská Bystrica, 97517
Alian s.r.o., kardiologicka ambulancia
Bardejov, 08501
Nemocnica Ruzinov-Univerzitna Nemocnica Bratislava (UNB)
Bratislava, Bratislava Region, 826 06
Metabol KLINIK s.r.o., Ambulancia pre diabetologiu, poruchy latkovej premeny a vyzivy
Bratislava, 811 08
Univerzitna nemocnica Bmtislava, Nemocnica Stare Mesto
Bratislava, 81369
Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto, l.interna klinika
Bratislava, 81369
Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto
Bratislava, 81369
UN Bratislava, Nemocnica Ruzinov, V. interna klinika LFUK a UN Bratislava
Bratislava, 826 06
Kardiovaskularne Centrum S.R.O.
Bratislava, 83101
Metabolicke Centrum MUDr. Katariny Raslovej, S.R.O.
Bratislava, 83101
Narodny ustav srdcovych a cievnych chorob, a.s.
Bratislava, 833 48
Univerzitna Nemocnica Bratislava
Bratislava, 83305
Narodny ustav srdcovych a cievnych chorob, a.s.
Bratislava, 83348
KARDIO-SANUS spol.,s.r.o.,Kardiologicka, interna a sonograficka ambulancia
Bratislava, 841 08
KARDIO-SANUS spol. s.r.o.
Bratislava, 84107
VERIA, s.r.o. -Kardiologicka ambulancia
Bratislava, 85101
UN Bratislava Nemocnica Sv.Cyrila a Metoda, kardiologicka ambulancia 1
Bratislava, 85107
Endiamed s.r.o. Nestatna diabetologicka a endokrinologicka ambulancia
Dolný Kubín, 02601
JM-Interna s.r.o., interna ambulancia
Dolný Kubín, 02601
CARDIO D&R s.r.o., Kardiologicka ambulancia
Košice, 040 01
AGTO., spol. s r. o.
Košice, 04011
Cardio D&R spol.s.r.o., kardiologicka ambulancia
Košice, 04022
Medicentrum Heart, Spol. S.R.O
Kráľovský Chlmec, 077 01
CELL-B s.r.o. interna ambulancia
Levice, 93405
Liptovska nemocnica s poliklinikou MUDr.Ivana Stodolu Liptovsky Mikulas
Liptovský Mikuláš, 031 23
Narodny Endokrinologicky A Diabetologicky Ustav N.O.
Ľubochňa, 034 91
KARDIO 1 s.r.o.
Lučenec, 984 39
Klinika hematologie a transfuziologie, Univerzitna nemocnica Martin
Martin, 036 59
MEDI M&M s.r.o., Ambulancia vnutorneho lekarstva
Moldava nad Bodvou, 045 01
MUDr. Kanderkova s.r.o., Diabetologicka ambulancia
Námestovo, 02901
Kardiocentrum Nitra s.r.o., kardiologicka ambulancia
Nitra, 94901
Fakultna nemocnica s poliklinikou Nove Zamky, I. interna klinika
Nové Zámky, 940 34
Mediab s.r.o. Diabetologicka ambulancia
Pezinok, 90201
BENIMED s.r.o.
Piešťany, 921 01
Medispol S.R.O.
Prešov, 08001
Medilex s.r.o. Interna ambulancia
Rimavská Sobota, 979 01
Kardioamb S.R.O.
Rimavská Sobota, 97901
DIAMEL, s.r.o., Diabetologicka ambulancia
Trenčín, 911 01
BV Medical, s.r.o. Diabetologicka ambulancia,
Trnava, 917 01
Kardiologicka ambulancia
Trnava, 917 01
Medivasa S.R.O., Diabetologicka Ambulancia
Žilina, 01001
Mexico37 sites
Centro de Investigacion Clinica del Pacifico, S.A. de C.V.
Acapulco de Juárez, Guerrero, 39670
Hospital Del Pacifico,Centro De Investigacion Clinica Del Pacifico Cicpa,Torre Medica Del Pacifico
Acapulco de Juárez, Guerrero, 39670
Instituto Biomedico De Investigacion A.C.
Aguascalientes, 20127
Hospital Cardiologica Aguascalientes
Aguascalientes, 20230
Consultorio Dr. Leocadio Gerardo Munoz Beltran
Cd. Juarez, Chihuahua, 32472
Unidad De Investigacion En Salud De Chihuahua S.C.
Chihuahua City, 31203
Consultorio Medico de Especialidad Dr. Demetrio Kosturakis Garcia
Chihuahua City, 31217
Investigacion en Salud y Metabolismo S.C
Chihuahua City, 31217
Instituto de Diabetes Obesidad y Nutricion, S.C.
Cuernavaca, Morelos, 62250
Hospital Inovamed Cuernavaca (Emergencies)
Cuernavaca, Morelos, 62270
Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C.
Culiacán, Sinaloa, 80020
Hospital Angeles Culiacan
Culiacán, Sinaloa, 80020
Instituto Nacional de Ciencia Medicas y Nutricion Salvador Zubiran
Distrito Federal, 14000
Lahoja Asociacion para la Investigacion y Farmacovigilancia S.C.
Durango, 34000
Centro de Investigacion Medica Integral S.C.
Guadalajara, Jalisco, 44160
Icle S.C.
Guadalajara, Jalisco, 44600
Consultorio Privado del Dr. Gabriel Arturo Ramos Lopez
Guadalajara, Jalisco, 44657
Unidad de Investigacion Clinica y Atencion Medica Hepa S.C.
Guadalajara, Jalisco, 44760
Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiovasculares, S.C.
México, 11650
Consultorio de Endocrinologia y Nutriologia
Mexico City, Mexico City, 07760
Operadora de Hospitales Angeles S.A. de C.V. (Emergencies)
Mexico City, Mexico City, 07760
Centro Especializado en Diabetes Obesidad y Prevencion de Enfermedades Cardiovasculares, SC.
Mexico City, Mexico City, 11650
Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran"
Mexico City, Mexico City, 14000
Cardiolink Clin Trials, S.C.
Monterrey, Nuevo León, 64060
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, Nuevo León, 64460
CRI Centro Regiomontano de Investigacion SC
Monterrey, Nuevo León, 64710
Global Trial Research Center S.A. de C.V.
Monterrey, Nuevo León, 64718
Clinical Trials Mexico, S.A. de C.V.
Pachuca, Hidalgo, 42070
Investigacion Biomedica Aplicada de Hidalgo S.A. de C.V.
Pachuca, Hidalgo, 42090
Pharmacology and Clinical Research S.A. de C.V.
Querétaro, 76000
Centro Integral Medico SJR S.C
San Juan del Río, Querétaro, 76800
Cardioarritmias e Investigacion S.C.
San Luis Potosí City, 78200
Hospital Lomas de San Luis lntemacional (Emergencies)
San Luis Potosí City, 78218
Hospital Central "Dr. Ignacio Morones Prieto"
San Luis Potosí City, 78240
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares S.C.
Tampico, Tamaulipas, 89000
Centro Especializado En Diabetes Y Metabolismo
Veracruz, 91910
Centro De Especialidades Medicas Del Estado De Veracruz
Xalapa, Veracruz, 91020
Belgium34 sites
Algemeen Stedelijk Ziekenhuis
Aalst, Oost-vlaanderen, 9300
ZNA Campus Middelheim
Antwerp, 2020
Imeldaziekenhuis Bonheiden
Bonheiden, 2820
VZW Algemeen Ziekenhuis KLINA
Brasschaat, Antwerpen, 2930
A.Z. St.Jan AV Brugge
Bruges, 8000
University Hospital Brussels - Centrum voor hart- en vaatziekten
Brussels, 1090
University Hospital Brussels- Diabeteskliniek
Brussels, 1090
Private Practice 'Cardiovascular Detection Center'
De Pinte, 9840
Az Sint Blasius
Dendermonde, Oost-vlaanderen, 9200
ZOL Campus Sint-Jan
Genk, 3600
AZ Sint Lucas Gent
Ghent, Oost-vlaanderen, 9000
Universitair Ziekenhuis Gent
Ghent, Oost-vlaanderen, 9000
AZ Maria Middelares
Ghent, 9000
Grand Hopital de Charleroi, Site St-Joseph
Gilly, 6060
Hygeia
Hasselt, 3500
Jessa Ziekenhuis
Hasselt, 3500
Sint-Franciskusziekenhuis
Heusden-Zolder, 3550
Centre Hospitalier Regional de Huy
Huy, 4500
Jan Yperman Ziekenhuis, Cardiology
Ieper, 8900
AZ Groeninge-Campus Loofstraat
Kortrijk, West-vlaanderen, 8500
Centre Hospitalier De Jolimont - Lobbes
La Louviere (Haine-Saint-Paul), 7100
Centre Hospitalier de Jolimont-Lobbes
La Louviere (Haine-Saint-Paul), 7100
University hospitals Leuven - Neurology department
Leuven, 3000
University hospitals Leuven
Leuven, 3000
Centre Hospitalier Universitaire (CHU) de Liege
Liège, 4000
Huisartsenpraktijk Medilink
Linkebeek, 1630
Huisartsenpraktijk Luc Capiau
Massemen, 9230
AZ Sint-Maarten
Mechelen, Antwerp, 2800
C.H.U. Ambroise Pare
Mons, 7000
Az Damiaan
Ostend, West-vlaanderen, 8400
Mariaziekenhuis vzw
Overpelt, 3900
Az Glorieux
Ronse, Oost-vlaanderen, 9600
AZ Nikolaas, Campus Moerland
Sint-Niklaas, Oost-vlaanderen, 9100
Dr. Luc De Wolf - Private Practice
Tienen, 3300
Hungary34 sites
DRC Kft.
Balatonfüred, 8230
DRC Kft.
Balatongyörök, 8313
Kardiologiai Maganrendelo
Békéscsaba, 5600
Grof Tisza Istvan Korhaz Berettyoujfalu
Berettyóújfalu, 4100
Budapesti Szent Ferenc Korhaz
Budapest, 1021
Synexus Magyarorszag Kft
Budapest, 1036
Szent Rokus Korhaz
Budapest, 1085
Semmelweis Egyetem
Budapest, 1088
Gottsegen Gyorgy Orszagos Kardiologiai Intezet
Budapest, 1096
Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointezet
Budapest, 1097
Egyesitett Szent Istvan Korhaz es Szent Laszlo Korhaz
Budapest, 1097
Semmelweis Egyetem
Budapest, 1125
Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak, III. Belgyogyaszat-Kardiologiai Osztaly
Budapest, 1125
Debreceni Egyetem
Debrecen, 4032
Synexus Magyarorszag Kft.
Gyula, 5700
Edes Szivunk Egeszsegkozpont Kft.
Hajdúszoboszló, 4200
BKS Research Kft., Albert Schweitzer Korhaz
Hatvan, 3000
Somogy Megyei Kaposi Mór Oktató Kórház
Kaposvár, 7400
Bacs-Kiskun Megyei Korhaz
Kecskemét, Bács-Kiskun county, 6000
Jutrix Egeszsegugyi Kft
Kecskemét, 6000
Megyei Flor Ferenc Korhaz
Kistarcsa, 2143
Pest Megyei Flor Ferenc Korhaz
Kistarcsa, 2143
Josa Andras Oktatokorhaz
Nyíregyháza, 4400
Medifarma-98 Kft.
Nyíregyháza, 4400
Pecsi Tudomanyegyetem AOK, II.
Pécs, Baranya, 7624
Pecsi Tudomanyegyetem AOK, I. Belgyogyaszati Klinika
Pécs, 7624
Szegedi Tudomanyegyetem AOK, I. sz Belgyogyaszati Klinika
Szeged, Csongrád megye, 6720
Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
Székesfehérvár, Fejér, 8000
Mentahaz Maganorvosi Kozpont
Székesfehérvár, 8000
Hetenyi Geza Korhaz
Szolnok, 5000
Markusovszky Egyetemi Oktatokarhaz
Szombathely, 9700
Dr. Sydo es Tsa Kft.
Veszprém, 8200
Zala Megyei Korhaz, Diabetológiai Szakrendelés
Zalaegerszeg, 8900
Zala Megyei Korhaz
Zalaegerszeg, 8900
Romania34 sites
CMI Pop Calin Florin
Baia Mare, JUD Maramures, 430123
Dr. Pop Calin Florin - Cabinet Cardiologie
Baia Mare, Maramureş, 430130
Euromedica Hospital
Baia Mare, 430032
Spitalul Clinic Judetean De Urgenta Braila(Braila County Clincal Emergency Hospital)
Brăila, 810249
S.C. Polimed Dacia S.R.L.
Brasov, 500209
Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL, Medicina Interna
Brasov, 500283
Clinica Medicala Synexus Ltd.
Bucharest, Sectorul 2, 021611
Data Plus Medical Clinic
Bucharest, 010192
Spitalul Universitar De Urgenta Militar Central, Dr. Carol Davila
Bucharest, 010825
"Prof. Dr. N.C. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases,
Bucharest, 020045
Spitalul Clinic Colentina, Departament Cardiologie
Bucharest, 020125
SC Centrul Medical Policlinico Di Monza SRL, Cardiologie
Bucharest, 021967
SC Policlinica CCBR SRL
Bucharest, 030463
Med Plus SRL (Med Plus Ltd.)
Bucharest, 061118
S.C. Centrul Medical "Sanatatea Ta" S.R.L.
Bucharest, 20614
Med Plus Srl
Bucharest, 61118
Spitalul Clinic Judetean De Urgenta Cluj-Napoca, Diabet Zabarat
Cluj-Napoca, 400006
Spitalul Clinic Judetean de Urgenta Cluj-Napoca, Diabet Zaharat, Nutritie si Boli Metabolice
Cluj-Napoca, 400006
County Emergency Hospital Deva
Deva, Hunedoara County, 330084
Dr. Mistodie Cristina Victoria MD, Office of
Galati, 800098
S.C. Diamed Obesity S.R.L.
Galati, 800291
Medical Practice SRL
Oradea, Bihor County, 410032
County Clinical Emergency Hospital Oradea
Oradea, Bihor County, 410169
Pitesti-Arges County Emergency Hospital
Piteşti, Argeş, 110084
Diabmed Dr. Popescu Alexandrina SRL, Diabet, Nutritie, Boli Metabolice
Ploieşti, Prahova, 100163
Dr. Busegeanu Mihaela Private Practice
Ploieşti, Prahova, 100342
County Emergency Hospital Satu Mare Diabetes, Nutrition And Metabolic Diseases Department
Satu Mare, 440055
County Clinical Emergency Hospital Sibiu
Sibiu, 550245
Podoleanu G. Cristian-Gheorghe-Calin - Cardiology Medical Practice
Târgu Mureş, Mureș County, 540143
Cardio Med SRL, Cardiologie
Tg. Mures, 540124
Centrul Medical Dr. Negrisanu SRL, Diabet Zaharat Nutritie si Boli Metabolice
Timișoara, Judet Timis, 300456
Institute of Cardiovascular Diseases Timisoara
Timișoara, Timiș County, 300310
Centrul Medical Sf. Stefan
Timișoara, 300125
Institution Centrul Medical Sf. Stefan SRL, Diabet Nutritie si Boli Metabolice
Timișoara, 300125
Czechia31 sites
Kardiologicka Ambulance
Brno, South Moravian, 638 00
CCBR Czech Brno, s.r.o.
Brno, 602 00
EDUMED s.r.o.
Broumov, Hradec Králové Region, 55001
DIKa centrum s.r.o., Kardiologicka a interni ambulance
Havířov, 73601
Fakultni nemocnice Hradec Kralove, III. Interni gerontometabolicka klinika
Hradec Králové, 500 05
Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05
Edumed S.R.O.
Jaroměř, Hradec Králové Region, 550 01
FREMLOVA APHOTECA s.r.o.
Litovel, Czech Republic, 78401
Kardio interna s.r.o.
Litovel, 784 01
Fakultni Nemocnice Olomouc
Olomouc, 775 00
Fakultni Nemocnice Olomouc
Olomouc, 77520
MUDr. Jan Vrkoc s.r.o.
Ostrava, Moravian-Silesian Region, 70200
BENU Lekarna
Pardubice, Czech Republic, 530 02
Pv-Kardiologie S.R.O.
Pardubice, Pardubice Region, 53002
CCBR Czech a.s.
Pardubice, 530 02
Kardiologie Plzen s.r.o.
Pilsen, 326 00
Fakultni poliklinika Vseobecne fakultni nemocnice v Praze
Prague, 128 08
CCBR Czech Prague, s.r.o
Prague, 130 00
Centrum kardiovaskularni prevence 1. LF UK a TN
Prague, 14059
Kardiologie a interni lekarstvi
Prague, 158 00
NEFROMED, s.r.o.
Prague, 160 00
Interna a kardiologie s.r.o.
Rožnov pod Radhoštěm, 756 61
Nemocnice Pardubickeho kraje, a.s., Svitavska nemocnice
Svitavy, 568 25
Vseobecna kardiologicka ambulance s.r.o.
Tábor, 390 03
Lekarna U Nemocnice
Tábor, 39003
Kardiologicka ambulance
Trutnov, Hradec Králové Region, 54101
Lekarna na Poliklinice
Trutnov, Hradec Králové Region, 54101
Lekarna Hradebni s.r.o.
Uherské Hradiště, 686 01
MUDr. Antonin Dufka, kardiologicka ambulance
Uherské Hradiště, 686 01
MUDr. Nina Zemkova s.r.o.
Uherské Hradiště, 686 01
KIGE s.r.o.
Znojmo, 66902
South Africa31 sites
IATROS International
Bloemfontein, Free State, 9301
JOSHA Research
Bloemfontein, Free State, 9301
Dr JM Engelbrecht Trial Site-Vergelegen Mediclinic
Cape Town, Western Cape, 7130
Tiervlei Trial Centre
Cape Town, Western Cape, 7530
Synopsis Research cc
Cape Town, Western Cape, 7700
Unitas Hospital.
Centurion, 0157
Suite 502
Durban, KwaZulu-Natal, 4001
Dr Ganesh c/o Dr NB Maharaj
Durban, KwaZulu-Natal, 4091
Clinresco Centres (Pty) Ltd-Central Professional Suits
Gauteng, 1619
Midrand Medical Centre
Halfway House, Gauteng, 1685
Centre for Diabetes and Endocrinology
Houghton Estate, Gauteng, 2198
Sunninghill Hospital
Johannesburg, Gauteng, 2157
I Engelbrecht Research (Pty) Ltd
Lyttelton, Gauteng, 0157
Nash Ranjith Research Centre
Merebank, Durban, KwaZulu-Natal, 4052
Zinakekele Medical Centre
Moloto South, Mpumalanga, 1022
Paarl Research Centre
Paarl, 7646
Charlotte Maxeke Johannesburg Academic Hospital
Parktown, Gauteng, 2193
TREAD Research cc
Parow, 7500
Medipark Centre for Clinical Research
Pretoria, Gauteng, 0158
Synexus Watermeyer Clinical Research Centre
Pretoria, Gauteng, 0184
Jongaie Research
Pretoria West, Gauteng, 0183
Roodepoort Medicross Clinical Research Centre
Roodepoort, Gauteng, 1724
Helderberg Research Institute
Somerset West, Western Cape, 7130
Synexus Helderberg Clinical Research Centre
Somerset West, Western Cape, 7130
Vergelegen Mediclinic-Helderberg Research Institute
Somerset West, Western Cape, 7130
Wits Clinical Research-Chris Hani Baragwanath Hospital
Soweto, Gauteng, 2013
Medi-Clinic Heart Hospital
Sunnyside, Gauteng, 0083
Limpopo Clinical Research Initiative
Thabazimbi, Limpopo, 0380
Welkom Clinical Trial Centre
Welkom, Free State, 9460
Drs Joynt Venter & Associates
Witbank (eMalahleni), Mpumalanga, 1035
Clinical Projects Research SA (Pty) Ltd
Worcester, 6850
Brazil29 sites
Universidade Federal do Para - Hospital Universitario Joao de Barros Barreto
Belém, Pará, 66073-000
CARDSEARCH/CARDRESEARCH - Cardiologia Assistencial e de Pesquisa LTDA
Belo Horizonte, Minas Gerais, 30150-240
Hospital Santa Isabel
Blumenau, Santa Catarina, 89010-906
Sociedade Hospitalar Angelina Caron/Hospital e Maternidade Angelina Caron
Campina Grande do Sul, Paraná, 83430-000
Loema Medicina e Bem Estar- Centro Especializado em Cardiologia Ltda.
Campinas, São Paulo, 13010-001
CAEP - Centro Avançado de Estudos e Pesquisas Ltda.
Campinas, São Paulo, 13087-567
Hospital Universitario - Associacao Educadora Sao Carlos - AESC
Canoas, Rio Grande do Sul, 92425-055
Hospital Santa Casa de Curitiba
Curitiba, Paraná, 80010-030
Quanta Diagnostico e Terapia / Medicina Nuclear Alto da XV
Curitiba, Paraná, 80045-170
Nucleo de Pesquisa Clínica
Curitiba, Paraná, 80730-150
Centro de Pesquisas em Diabetes e Doencas Endocrino-Metabolicas Ltda
Fortaleza, Ceará, 60430-140
Covance Central Laboratory Services
Indianapolis, Indiana, 46214-2985
CARDSEARCH/CARDRESEARCH - Cardiologia Assistencial e de Pesquisa LTDA
Minas Gerais, 30150-240
Irmandade Santa Casa de Misericordia de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90020-090
Hospital Mae de Deus/Associacao Educadora Sao Carlos AESC / IMV - Instituto de Medicina Vascular
Porto Alegre, Rio Grande do Sul, 90110-270
Instituto de Cardiologia do Rio Grande do Sul / Fundacao Universitaria de Cardiologia
Porto Alegre, Rio Grande do Sul, 90620-001
Hospital Mae de Deus - Instituto do Cancer
Porto Alegre, Rio Grande do Sul, 90840-440
Hospital Mae de Deus-Associacao Educadora de Sao Carlos-AESC/IMV - Instituto de Medicina Vascular
Porto Alegre, Rio Grande do Sul, 90840-440
Mae de Deus - Centro de Oncologia Radioterapica (COR)
Porto Alegre, Rio Grande do Sul, 90840-440
Centro de Pesquisas Medicas Basica e Clinica LTDA
Recife, Pernambuco, 52020-010
Hospital Agamenon Magalhaes
Recife, Pernambuco, 52051-380
CCBR Brasil - Centro de Pesquisa e Analises Clinicas LTDA
Rio de Janeiro, Rio de Janeiro, 22271-100
Fundacao Bahiana De Cardiologia
Salvador, Estado de Bahia, 41810-010
HBA S/A ASSISTENCIA MEDICA E HOSPITALAR-Hospital da Bahia
Salvador, Estado de Bahia, 41810-011
IMC - Instituto de Molestias Cardiovasculares/Equipamentos Cardiovasculares Rio Preto Ltda
São José do Rio Preto, São Paulo, 15015210
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP)
São Paulo, São Paulo, 05403-010
CPClin- Centro de Pesquisas Clinicas Ltda./Clinica Dr. Freddy Goldberg Eliaschewitz
São Paulo, 01244-030
FGM-Clinica Paulista de Doencas Cardiovasculares
São Paulo, 01327-010
CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda
São Paulo, 04266-010
Denmark26 sites
Sygehus Sonderjylland Aabenraa
Aabenraa, 6200
Aalborg Universitetshospital, Lipidklinikken
Aalborg, 9000
CCBR Aalborg
Aalborg, 9000
Aarhus Universitetshospital Skejby, Hjertesygdomme ¿ Klinisk Forskning
Aarhus, 8200
Aarhus Universitetshospital
Aarhus N, 8250
CCBR Ballerup
Ballerup Municipality, 2750
Bispebjerg og Frederiksberg Hospital
Copenhagen NV, 2400
Rigshospitalet
Copenhagen Oe, 2100
Sydvestjysk Sygehus
Esbjerg, 6700
Frederiksberg Hospital
Frederiksberg, 2000
Glostrup Hospital
Glostrup Municipality, 2600
Herlev Universitetshospital, Kardiologisk afdeling S
Herlev, 2730
Regionshospitalet Herning
Herning, 7400
Hillerod Hospital
Hillerød, 3400
Hvidovre Universitetshospital, Hjerte-lungemedicinsk afdeling
Hvidovre, 2650
Amager Hospital
København S, 2300
Region Sjaelland Sygehus Nord, Koge Sygehus
Køge, 4600
Kolding Sygehus
Kolding, 6000
Region Sjaelland Naestved Sygehus
Næstved, 4700
Nykobing F. Sygehus-Medicinsk afdeling
Nykøbing Falster, 4800
Regionshospitalet Randers
Randers, 8930
Regionshospitalet Silkeborg, Hjerte Projektkontor
Silkeborg, 8600
Slagelse Sygehus
Slagelse, 4200
Svendborg Sygehus
Svendborg, 5700
CCBR Vejle
Vejle, DK 7100
Hospitalsenheden Midt, Regionshospital Viborg
Viborg, 8800
Australia25 sites
Adelaide Medical Research
Ashford, South Australia, 5035
SA Heart
Ashford, South Australia, 5035
Eastern Health - Box Hill Hospital
Box Hill, Victoria, 3128
Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders
Camperdown, New South Wales, 2050
Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050
Holy Spirit Northside Private Hospital Limited
Chermside, Queensland, 4032
Southern Adelaide Diabetes and Endocrine Service
Daws Park, South Australia, 5041
Department of Cardiology, Lyell McEwin Hospital
Elizabeth Vale, South Australia, 5112
The Northern Hospital
Epping, Victoria, 3076
Central Coast Neurosciences Research
Erina, New South Wales, 2250
Fremantle Hospital
Fremantle, Western Australia, 6160
Heart and Vascular Research
Fullarton, South Australia, 5063
Barwon Health-The Geelong Hospital
Geelong, Victoria, 3220
Central Coast Local Health District, Gosford Hospital
Gosford, New South Wales, 2250
Austin Health - Heidelberg Repatriation Hospital
Heidelberg West, Victoria, 3081
Royal Brisbane and Women's Hospital
Herston, Queensland, 4029
HPS Pharmacies
Joondalup, Western Australia, 6027
Joondalup Cardiovascular Trials Foundation Inc.
Joondalup, Western Australia, 6027
Launceston General Hospital
Launceston, Tasmania, 7250
Australian Clinical Research Network
Maroubra, New South Wales, 2035
Alfred Hospital
Melbourne, Victoria, 3004
Core Research Group Pty Ltd
Milton, Queensland, 4064
Redcliffe Hospital
Redcliffe, Queensland, 4020
Austrials Pty Ltd
Sherwood, Queensland, 4075
Gold Coast University Hospital
Southport, Queensland, 4215
France24 sites
CHU Jean Minjoz Cardiologie
Besançon, 25000
Centre Hospitalier De Bourg En Bresse - Hopital Fleyriat
Bourg-en-Bresse, 01012
CHU de Caen
Caen, 14033
Centre Hospitalier de Cannes- Service de Cardiologie
Cannes, 06414
Centre Hospitalier Sud-Francilien
Corbeil-Essonnes, 91106
Scp Cardiovasculaire De L'Est
Essey-lès-Nancy, 54270
Centre Hospitalier Louis Pasteur
Le Coudray, 28630
Hopital La Louviere
Lille, 59000
Centre Hospitalier Saint Philibert
Lomme, 59462
Hopital Cardiovasculaire Et Pneumologique Louis Pradel
Lyon, 69394
Hopital Arnaud de Villeneuve
Montpellier, 34295
CHU de Nantes - Hopital Nord Laennec
Nantes, 44093
Nouvelles Cliniques Nantaises
Nantes, 44200
CHU Caremeau
Nîmes, 30000
CHU Caremeau
Nîmes, 30029
Centre Hospitalier de PAU
Pau, 64046
Hopital Cardiologique
Pessac, 33604
CHU de Poitiers
Poitiers, 86021
CHU de Renes Hopital de Pontchaillou
Rennes, 35033
CHU de Toulouse
Toulouse, 31059
Hopital Guy Chatiliez
Tourcoing, 59200
Hopital Trousseau
Tours, 37044
Centre Hospitalier (CH) de Valenciennes
Valenciennes, 59300
Polyclinique Vauban
Valenciennes, 59300
Israel24 sites
Barzilai Medical Center
Ashkelon, 7830604
Ben Yair Community Clinic - Clalit Health Services
Beersheba, 84350
Heart Institute, Hillel Yaffe Medical Center
Hadera, 38100
Rambam Medical Center
Haifa, 31096
Cardiovascular Clinical Research Institute
Haifa, 34362
Edith Wolfson Medical Center
Holon, 58100
Hadassah Ein Kerem Medical Center
Jerusalem, 91120
Meir Medical Center
Kfar Saba, 44281
Galilee Medical Center, Cardiology Department
Nahariya, 22100
E.M.M.S Nazareth Hospital
Nazareth, 16100
Rabin Medical Center, Beilinson Hospital
Petah Tikva, 49100
Rabin Medical Center-Beilinson Hospital
Petah Tikva, 49100
Rabin Medical Center
Petah Tikva, 49100
Sha'aria Clinic, Clalit Health Services
Petah Tikva, 4958202
Shuali Community Clinic, Clalit Health Services
Raanana, 43452
Department of Neurology & Sagol Neuroscience Center
Ramat Gan, 52621
Heart Institute, Kaplan Medical Center
Rehovot, 76100
Kaplan Medical Center Metabolism and Diabetes Clinic, Kaplan Medical Center
Rehovot, 76100
Internal Medicine A, Ziv Medical Center
Safed, 13100
Ziv Medical Center
Safed, 13100
Tel Aviv Sourasky Medical Center
Tel Aviv, Tel Aviv, 64239
Tel Aviv Sourasky Medical Center
Tel Aviv, 64239
Assuta Medical Center
Tel Aviv, 6789140
The Chaim Sheba Medical Center
Tel HaShomer, 5265601
Italy22 sites
S. C. Cardiologia INRCA
Ancona, 60124
Ospedale Civile Regionale San Martino, Belluno
Belluno, 32100
Azienda Ospedaliera G. Brotzu
Cagliari, 09124
AOU Policlinico "Mater Domini" UOC di Medicina Interna
Catanzaro, CZ, 88100
Azienda Ospedaliera Della Provincia Di Lecco - Ospedale Manzoni
Lecco, Province OF Lecco, 23900
Ospedale S. L. Mandic di Merate
Merate, Lecco, 23807
Covance Central Laboratory Services
Meyrin/Geneve, Geneve, 1217
Unità Operativa Solventi e Unità Poliambulatorio
Milan, 20138
Department of Clinical Medicines and Cardiovascular Sciences, Universita "Federico II" di Napoli
Naples, 80131
Divisione di Cardiologia con Utic ed Emodinamica - AOU Federico II di Napoli
Naples, 80131
Dipartimento delle Patologie Emergenti, Unita di Medicina Interna e Dislipidemie Genetiche
Palermo, PA, 90127
Ospedale S. Maria della Misericordia -Dipartimento di Medicina, Medicina Interna,
Perugia, PG, 06132
A.O. di Reggio Emilia Arcispedale "S. Maria Nuova"/IRCCS
Reggio Emilia, 42123
AUSL Della Romagna-Ospedale Infermi
Rimini, 47923
Dip Medicina Interna e Specialita Mediche, Policlinico Umberto I
Roma, RM, 00161
Policlinico Umberto I di Roma
Rome, RM, 00161
Azienda Ospedaliera S'Andrea di Roma - UOC Cardiologia
Rome, RM, 00189
Ospedale Santa Maria della Misericordia Azienda ULSS 18 of Rovigo
Rovigo, 45100
Ospedale G. Fracastoro
San Bonifacio, Verona, 37047
A.O. Treviglio e Caravaggio
Treviglio (BG), Bergamo, 24047
Azienda Ospedaliera Universitaria Santa Maria della Misericordia
Udine, 33100
AOUI di Verona - Ospedale Civile Maggiore Borgo Trento
Verona, VR, 37126
Finland21 sites
Linnan Klinikka Oy
Hämeenlinna, 13100
Mehilainen Toolo
Helsinki, 00260
Helsinki University Central Hospital
Helsinki, 00290
Helsingin yliopistollinen keskussairaala, Sisaetaudit ja kuntoutus, Biomedicum 2U
Helsinki, FI-00290
Ita-Suomen laakarikeskus Oy
Joensuu, 80100
Studycor Oy
Jyväskylä, 40620
Laeaekaerikeskus Aava Kerava
Kerava, 04200
Menoa oy
Kinkomaa, 40930
Kokkolan Keskussairaala
Kokkola, 67200
Mewell liikuntaklinikka
Kotka, 48600
Itae-Suomen Laeaekaeritalo Oy
Kuopio, 70100
Terveystalo Kuopio
Kuopio, 70100
Oulu Mentalcare Oy
Oulu, 90100
Terveystalo Oulu, Diapolis
Oulu, 90100
Oulu University Hospital
Oulu, 90220
Porin Laakaritalo Oy
Pori, 28100
Terveystalo Siilinjarvi
Siilinjärvi, 71800
FinnMedi Oy
Tampere, 33520
Terveystalo Pulssi
Turku, 20100
Turku University Hospital
Turku, 20520
Vantaan Tutkimuskeskus
Vantaa, 01600
South Korea21 sites
Inje University Busan Paik Hospital
Busan, 47392
Dong-A University Hospital
Busan, 49201
Chungbuk National University Hospital
Cheongju-si, Chungcheonbuk-do, 362-711
Kangwon National University Hospital
Chuncheon, Gangwon-do, 24289
Daegu Catholic University Medical Center
Daegu, 42472
Dongguk University Ilsan Hospital
Goyang-si, Gyeonggi-do, 10326
Inje University Ilsan Paik Hospital
Goyang-si, Gyeonggi-do, 10380
Myongji Hospital
Goyang-si, Gyeonggi-do, 10475
Donguk University Gyeongju Hospital
Gyeongju, Gyeongsangbuk-do, 780-350
Gachon University Gil Medical Center
Incheon, 21565
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620
Asan Medical Center
Seoul, 05505
Seoul Medical Center
Seoul, 131-795
Hallym University Kangdong Sacred Heart Hospital
Seoul, 134-701
Gangnam Severance Hospital, Yonsei University Health System
Seoul, 135-720
The Catholic University Of Korea Seoul St.Marys Hospital
Seoul, 137-701
Seoul Metropolitan Government - Seoul National University Boramae Medical Center
Seoul, 156-707
Ajou University Hospital
Suwon, Gyeonggi-do, 443-380
Uijeongbu St. Mary's Hospital-The Catholic University of Korea
Uijeongbu-si, Gyeonggi-do, 11765
Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, 26426
Yonsei University Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, 26426
Colombia20 sites
Clinica de la Costa LTDA
Barranquila, Atlántico
Centro Cientifico Asistencial Jose Luis Accini S.A.S.
Barranquilla, Atlántico, 80020
Corazon Ips S.A.S.
Barranquilla, Atlántico, 80020
Corozan Ips Sas
Barranquilla, Atlántico
Fundacion del Caribe para la Investigacion Biomedica - Fundacion BIOS
Barranquilla, Atlántico
Dexadiab Servicios Medicos LTDA
Bogota D.C, Cundinamarca, 110221
Caja de Compensacion Familiar CAFAM, Sede Centro de Atencion en Salud CAFAM FLORESTA
Bogota D.C, Cundinamarca, 111211
Hospital Universitario San Ignacio
Bogota D.C, Cundinamarca
Instituto de Investigacion Endocrinologia y Prevencion Metabolica - ENDOCARE LTDA.
Bogota D.C, Cundinamarca
MedPlus Medicina Prepagada S.A.
Bogota D.C., Cundinamarca, 110911
Solano & Terront Servicios Medicos Ltda-Establecimiento Comercial UNIENDO
Bogota D.C., Cundinamarca
Instituto del Corazon de Bucaramanga S.A.
Bucaramanga, Santander Department
Fundacion Reina Isabel
Cali, Valle del Cauca Department, 760001
Centro de Diagnostico Cardiologico LTDA.
Cartagena, Departamento de Bolívar
Fundación Cardiovacular de Colombia - Instituto del Corazón de Floridablanca
Floridablanca, Santander Department
Asociacion IPS Medicos Internistas de Caldas
Manizales, Caldas Department
Hospital Pablo Tobon Uribe
Medellín, Antioquia, 00000
Rodrigo Botero S.A.S
Medellín, Antioquia, 50012
Centro de Investigacion Clinica Avanzada y Multidisciplinaria CICLAM
Medellín, Antioquia
Centro de Medicina del Ejercicio y Rehabilitacion Cardiaca S.A. CEMDE S.A.
Medellín, Antioquia
Turkey (Türkiye)20 sites
Baskent University, Adana Yuregir Training & Research Hospital
Adana, 01250
A.karahisar Kocatepe Universitesi Hastanesi Ahmet Needet Sezer Uygulama ve
Afyonkarahisar, 03200
Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi
Ankara, 06110
Ufuk University School of Medicine, Dr. Ridvan Ege Training & Research Hospital
Ankara, 06520
Akdeniz Universitesi Tip Fakultesi
Antalya, 07059
Antalya Training & Research Hospital
Antalya, 07100
Adnan Menderes Universitesi Uygulama ve Arastirma Hastanesi
Aydin, 09100
Bursa Yuksek Ihtisas Egitim ve Arastirma Hastanesi
Bursa, 16320
Firat Universitesi
Elâzığ, 23119
Gaziantep Universitesi Tip Fakultesi Sahinbey Egitim ve Arastirma Hastanesi
Gaziantep, 27310
Bezmialem Vakif Universitesi Tip Fakultesi Kardiyoloji Bolurnu
Istanbul, 34093
Istanbul Universitesi Istanbul Tip Fakultesi
Istanbul, 34093
Istanbul Universitesi Kardiyoloji Enstitusu
Istanbul, 34096
Ege University, School of Medicine
Izmir, 35100
Izmir Tepecik Egitim ve Arastirma Hastanesi
Izmir, 35170
Dokuz Eylul Universitesi Tip Fakultesi Hastanesi
Izmir, 35340
Dokuz Eylul Universitesi Tip Fakultesi
Izmir, 35340
Kocaeli University School Of Medicine-Kocaeli Universitesi Tip Fakultesi
Kocaeli, 41380
Mersin University, School of Medicine
Mersin, 33343
Recep Tayyip Erdogan University School of Medicine, Training & Research Hospital
Rize, 53020
New Zealand19 sites
North Shore Hospital, Laboratory
Auckland, 0622
North Shore Hospital- Inpatient Pharmacy
Auckland, 0622
Optimal Clinical Trials
Auckland, 1010
Auckland City Hospital
Auckland, 1023
Middlemore Clinical Trials
Auckland, 2025
Lipid and Diabetes Research Group
Christchurch, 8011
Southern Clinical Trials Shirley Ltd Don Beavan Medical Research Centre
Christchurch, 8011
Southern Clinical Trials Riccarton
Christchurch, 8041
Hawke's Bay Hospital
Frimley, Hastings, 4120
Henderson Medical Centre
Henderson, Auckland, 0612
Taranaki Base Hospital
New Plymouth, 4310
Papamoa Pines Medical Centre
Papamoa, 3118
Rotorua Hospital
Rotorua, 3010
North Shore Hospital
Takapuna, Auckland, 0622
Clinical Horizons NZ Ltd
Tauranga, 3112
Clinical Trials Unit,Bay of Plenty(BOP) Clinical School
Tauranga, 3112
CCDHB, Wellington Hospital, Clinical Measurement Unit
Wellington, 6021
Wellington Hospital
Wellington, 6021
Wellington Regional Hospital
Wellington, 6242
Sweden18 sites
Kasernens Läkarservice AB
Eksjö, 57535
Sahlgrenska Universitetssjukhuset
Gothenburg, 41345
Pharmasite AB
Helsingborg, 252 20
Medicinklinikens forskningsenhet
Kristianstad, 291 85
Hjartmottagningen, Capio Citykliniken
Lund, 222 21
Probar E Lund AB
Lund, 222 22
Karlkliniken, Skanes Universitetssjukhus i Malmo
Malmö, 205 02
Pharmasite AB
Malmö, 211 52
Forskningsenheten, Medicinmottagningen Sahlgrenska Universitetssjukhuset/Molndal, Hus J
Mölndal, 431 80
Ostersunds Sjukhus
Östersund, 83183
Dalecarlia Clinical Research Center
Rättvik, 79530
Skelleftea Lasarett
Skellefteå, 93186
Karolinska universitetssjukhuset Huddinge
Stockholm, Huddinge, 141 86
A+Science City site
Stockholm, 111 57
Karolinska Universitetssjukhuset
Stockholm, 17176
Hjartkliniken
Stockholm, 182 82
Akademiska Sjukhuset
Uppsala, 75185
Vastmanlands Sjukhus Vasteras
Västerås, 721 89
Switzerland10 sites
Universitatsspital
Basel, Canton of Basel-City, 4031
Hospitaux Universitaires de Geneve (HUG)
Geneva, Canton of Geneva, 1211
Policlinique Medicale Universitaire
Lausanne, Canton of Vaud, 1011
Centre Hospitalier Universitaire Vaudois
Lausanne, 1011
Luzerner Kantonsspital Luzern
Lucerne, CH-6000
Cardiocentro Ticino
Lugano, CH-6900
Fondazione Diabete Lugano
Lugano, CH-6900
Diagene Laboratories Inc.
Reinach, Basel, 4153
Kantonsspital St. Gallen
Sankt Gallen, CH-9007
Kantonsspital Winterthur
Winterthur, Canton of Zurich, 8401
Chile9 sites
Corporacion de Beneficencia Osorno
Osorno, Los Lagos Region, 5311092
Biomedica Research Group
Providencia Santiago, Santiago Metropolitan, 7500710
Quantum Research
Puerto Varas, 5550170
CICAB
Santiago, Santiago Metropolitan, 7500021
Servicios Medicos Godoy
Santiago, Santiago Metropolitan, 7500710
SMOLAM
Santiago, Santiago Metropolitan, 7500739
Complejo Asitencial Dr. Sotero del Rio
Santiago, Santiago Metropolitan, 8207257
Hospital y CRS El Pino
Santiago, 8053095
Centro de Investigacion Clínica del Sur
Temuco, Araucania, 4781156
India9 sites
Dr. Jivraj Mehta Smarak Health Foundation, Bakeri Medical Research Centre
Ahmedabad, Gujarat, 380007
Apex Heart Institute (A Unit of TCVS Pvt. Ltd)
Ahmedabad, Gujarat, 380054
SAL Hospital
Ahmedabad, Gujarat, 380054
M.V. Hospital And Research Centre
Lucknow, Uttar Pradesh, 226003
Jehangir Clinical Development Centre Pvt. Ltd.
Pune, Maharashtra, 411001
Apple Hospital
Surat, Gujarat, 395 002
Unicare Heart Institute & Research Center
Surat, Gujarat, 395002
BAPS - Pramukh Swami Hospital
Surat, Gujarat, 395009
Rhythm Heart Institute
Vadodara, Gujarat, 390022
Taiwan9 sites
Kaohsiung Medical University Chung-Ho Memorial Hospital - New
Kaohsiung City, 807
Cardinal Tien Hospital
New Taipei City, 23148
China Medical University Hospital
Taichung, Taiwan R O C, 40447
Chung Shan Medical University Hospital
Taichung, 402
National Cheng Kung University (NCKU) Hospital
Tainan, 70428
National Taiwan University Hospital
Taipei, Taiwan R O C, 10002
National Taiwan University Hospital
Taipei, 10041
MacKay Memorial Hospital
Taipei, 10449
Taipei Veterans General Hospital
Taipei, 11217
Puerto Rico7 sites
The Office of Roberto J. Ayala-Rios, MD - Research Center and Private Practice (DMRA LLC)
Anasco, 00610
Cardiometabolic Research Center, Inc.
Ponce, PR, 00717
Endocrine Lipid Diabetes Research Institute
Ponce, PR, 00717
Miguel Sosa-Padilla, MD-Private Practice
San Juan, PR, 00926-2832
Pradnet Inc.
San Juan, 00917
Altamira Family Medicine And Research Institute
San Juan, 00920
Centro de Diabetes para Puerto Rico
San Juan, 00935
Thailand5 sites
Cardiology Unit,Department of Medicine, Faculty of Medicine, Ramathibodi Hospital,
Bangkok, 10400
Division Of cardiology,Department of Medicine,Faculty Of Medicine,Chulalongkorn University
Bangkok, 10400
Division of Cardiology, Department of Medicine, Faculty of Medicine, Siriraj Hospital,
Bangkoknoi, Bangkok, 10700
Heart Center, Songklanagarind Prince of Songkla University
Hat Yai, Changwat Songkhla, 90110
Faculty of Medicine, Srinagarind Hospital, Khon Kaen University
Muang, Changwat Khon Kaen, 40002
Ireland2 sites
Beaumont Hospital
Dublin, Leinster, 9
St James's Hospital
Dublin, 8
About this study
Official title: Phase 3 Multi Center, Double Blind, Randomized, Placebo Controlled, Parallel Group Evaluation Of The Efficacy, Safety, And Tolerability Of Bococizumab (Pf-04950615), In Reducing The Occurrence Of Major Cardiovascular Events In High Risk Subjects
This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and unstable angina requiring urgent revascularization in high risk subjects who are receiving background lipid lowering therapy and have cholesterol laboratory values of LDL-C >/= 100 mg/dL (2.6 mmol/L) or non-HDL-C >/=130 mg/dL (3.4 mmol/L).
Read the detailed description
The trial was terminated prematurely on November 1, 2016, due to the emerging clinical profile and the evolving treatment and market landscape for lipid-lowering agents. These indicated that bococizumab was not likely to provide value to patients, physicians, or shareholders. The decision was not based on a recommendation by the independent Data Monitoring Committee to stop the program.
- Conditions
- Cardiovascular Disease
- Being tested
- bococizumab (PF-04950615), Placebo
- Keywords
- myocardial infarction, stroke, hyperlipidemia
- Medical subject headings
- Cardiovascular Diseases, Myocardial Infarction, Stroke, Hyperlipidemias
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
bococizumab (PF-04950615)Drug
Also called RN316
150 mg, every 2 weeks, subcutaneous. The duration of the treatment period will depend upon reaching the targeted number of adjudicated and confirmed CV outcome events, approximately 3 to 4 years after the entry of first subject into the study.
PlaceboDrug
Placebo comparator, every 2 weeks, subcutaneous. The duration of the treatment period will depend upon reaching the targeted number of adjudicated and confirmed CV outcome events, approximately 3 to 4 years after the entry of first subject into the study.
| Study group | Role | What they receive |
|---|---|---|
| bococizumab (PF-04950615) | Experimental | 150 mg, every 2 weeks, subcutaneous. Receives: Drug: bococizumab (PF-04950615) |
| Placebo | Placebo comparator | Placebo comparator, every 2 weeks, subcutaneous. Receives: Drug: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Event Rate Per 100 Participant-years for First Occurrence of Major Cardiovascular (CV) Event
Event rate per 100 participant-years for first occurrence of major CV event (adjudicated by Adjudication Committee) was reported. Major CV event was defined as any of the following: CV death [defined as sudden cardiac death, fatal myocardial infarction (MI), death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other CV causes] non-fatal MI, non-fatal stroke, and hospitalization for unstable angina needing urgent revascularization. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of major CV event (maximum duration: up to 3.4 years)
Secondary outcomes (26)
Event Rate Per 100 Participant-years for First Occurrence of Composite Endpoint of Cardiovascular (CV) Death, Non-fatal Myocardial Infraction (MI) or Non-fatal Stroke
Event rate per 100 participant-years for first occurrence of composite endpoint of CV Death, non-fatal MI or non-fatal stroke (adjudicated by Adjudication Committee) was reported. CV death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other CV causes. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of CV death, non-fatal MI or non-fatal stroke (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Composite Endpoint of All-cause Death, Non-fatal Myocardial Infraction (MI), Non-fatal Stroke or Hospitalization for Unstable Angina Needing Urgent Revascularization
Event rate per 100 participant-years for first occurrence of composite endpoint of all-cause death, non-fatal MI, non-fatal stroke or hospitalization for unstable angina needing urgent revascularization (adjudicated by Adjudication Committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of all-cause death, non-fatal MI, non-fatal stroke or hospitalization for unstable angina needing urgent revascularization (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Composite Endpoint of All-cause Death, Non-fatal Myocardial Infarction (MI) or Non-fatal Stroke
Event rate per 100 participant-years for first occurrence of composite endpoint of all-cause death, non-fatal MI or non-fatal stroke (adjudicated by Adjudication Committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of all-cause death, non-fatal MI or non-fatal stroke (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Hospitalization for Unstable Angina Needing Urgent Revascularization
Event rate per 100 participant-years for first occurrence of hospitalization for unstable angina needing urgent revascularization (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for unstable angina needing urgent revascularization (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Composite Endpoint of Cardiovascular (CV) Death, Non-fatal Myocardial Infarction (MI), Non-fatal Stroke or Hospitalization for Unstable Angina
Event rate per 100 participant-years for first occurrence of composite endpoint of CV death, non-fatal MI, non-fatal stroke or hospitalization for unstable angina (adjudicated by Adjudication Committee) was reported. CV death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other CV causes. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of CV death, non-fatal MI, non-fatal stroke or hospitalization for unstable angina (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for Cardiovascular (CV) Death
Event rate per 100 participant-years for occurrence of CV death (adjudicated by Adjudication Committee) was reported. CV death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other CV causes. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of adjudicated and confirmed occurrence of CV death (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Any Myocardial Infarction (Fatal or Non-fatal)
Event rate per 100 participant-years for first occurrence of any myocardial infarction (fatal or non-fatal) (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of any myocardial infarction (fatal or non-fatal) (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for Fatal Myocardial Infarction (MI)
Event rate per 100 participant-years for occurrence of fatal MI (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of adjudicated and confirmed occurrence of fatal MI (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Non-fatal Myocardial Infarction (MI)
Event rate per 100 participant-years for first occurrence of non-fatal MI (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of non-fatal MI (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Any Stroke (Fatal or Non-fatal)
Event rate per 100 participant-years for first occurrence of any stroke (fatal or non-fatal) (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of any stroke (fatal or non-fatal) (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Any Stroke (Fatal or Non-fatal), of Any Etiology
Event rate per 100 participant-years for first occurrence of any stroke (fatal or non-fatal) of any etiology (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of any stroke (fatal or non-fatal) of any etiology (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for Fatal Stroke
Event rate per 100 participant-years for occurrence of fatal stroke (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of adjudicated and confirmed occurrence of fatal stroke (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Non-fatal Stroke
Event rate per 100 participant-years for first occurrence of non-fatal stroke (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of non-fatal stroke (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Hospitalization for Unstable Angina
Event rate per 100 participant-years for first occurrence of hospitalization for unstable angina (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for unstable angina (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Hospitalization for Congestive Heart Failure (CHF)
Event rate per 100 participant-years for first occurrence of hospitalization for CHF (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for CHF (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Coronary Revascularization
Event rate per 100 participant-years for first occurrence of coronary revascularization (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of coronary revascularization (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Coronary Artery Bypass Graft Surgery (CABG)
Event rate per 100 participant-years for first occurrence of CABG (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of CABG (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Percutaneous Coronary Intervention (PCI)
Event rate per 100 participant-years for first occurrence of PCI (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of PCI (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Any Arterial Revascularizations
Event rate per 100 participant-years for first occurrence of any arterial revascularizations (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of first adjudicated and confirmed occurrence of any arterial revascularizations (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for All-cause Death
Event rate per 100 participant-years for occurrence of all-cause death (adjudicated by Adjudication Committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk.
Measured: From baseline until the date of adjudicated and confirmed occurrence of all-cause death (maximum duration: up to 3.4 years)
Percent Change From Baseline in Low Density Lipoprotein Cholesterol (LDL-C) at Week 14
Measured: Baseline, Week 14
Nominal Change From Baseline in Low Density Lipoprotein Cholesterol (LDL-C) at Week 14
Measured: Baseline, Week 14
Percent Change From Baseline in Low Density Lipoprotein Cholesterol (LDL-C) at Last Post-baseline Measurement
Measured: Baseline, last post-baseline measurement (any time up to Week 140)
Percent Change From Baseline in Lipid Levels at Week 14
Lipids included non-high density lipoprotein cholesterol (non-HDL-C), very low density lipoprotein cholesterol (VLDL-C), remnant lipoprotein cholesterol (RLP-C), apolipoprotein B (Apo B), HDL-C, apolipoprotein A-I (Apo A-I) and total cholesterol.
Measured: Baseline, Week 14
Percent Change From Baseline in Log-transformed Triglycerides and Lipoprotein (a) (Lp[a]) at Week 14
Measured: Baseline, Week 14
Percent Change From Baseline in Log-transformed High Sensitivity C-Reactive Protein (Hs-CRP) at Week 14
Measured: Baseline, Week 14
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Nov 2013 (estimated)
- Study start29 Oct 2013
- Primary completion3 Apr 2017
- Study completion3 Apr 2017
Why it stopped: See Detailed Description
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Cardiovascular DiseaseStudies of the same condition, open and under way.
- More trials run by PfizerThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 10,564 participants (actual)
Sponsor and investigators
- Lead sponsor
- Pfizer
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Pfizer CT.gov Call Center, Study director, Pfizer
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01975389
- Sponsor's protocol ID
- B1481038
- Other IDs
- CV OUTCOMES 2, 2013-002795-41
- Acronym
- SPIRE-2
- Status last verified
- Apr 2019
- First submitted
- 21 Oct 2013
- Last updated
- 1 May 2019
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
Publications
Chasman DI, Hyde CL, Giulianini F, Danning RD, Wang EQ, Hickling T, Ridker PM, Loomis AK. Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1. Sci Rep. 2022 Mar 11;12(1):4266. doi: 10.1038/s41598-022-07997-5.
PubMed 35277540Pradhan AD, Aday AW, Rose LM, Ridker PM. Residual Inflammatory Risk on Treatment With PCSK9 Inhibition and Statin Therapy. Circulation. 2018 Jul 10;138(2):141-149. doi: 10.1161/CIRCULATIONAHA.118.034645. Epub 2018 May 1.
PubMed 29716940Ridker PM, Rose LM, Kastelein JJP, Santos RD, Wei C, Revkin J, Yunis C, Tardif JC, Shear CL; Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Investigators. Cardiovascular event reduction with PCSK9 inhibition among 1578 patients with familial hypercholesterolemia: Results from the SPIRE randomized trials of bococizumab. J Clin Lipidol. 2018 Jul-Aug;12(4):958-965. doi: 10.1016/j.jacl.2018.03.088. Epub 2018 Apr 3.
PubMed 29685591Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC; SPIRE Cardiovascular Outcome Investigators. Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients. N Engl J Med. 2017 Apr 20;376(16):1527-1539. doi: 10.1056/NEJMoa1701488. Epub 2017 Mar 17.
PubMed 28304242
Study at a glance
From the registry record, last updated by the sponsor on 1 May 2019. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Phase 3 Multi Center, Double Blind, Randomized, Placebo Controlled, Parallel Group Evaluation Of The Efficacy, Safety, And Tolerability Of Bococizumab (Pf-04950615), In Reducing The Occurrence Of Major Cardiovascular Events In High Risk Subjects
- ClinicalTrials.gov ID
- NCT01975389
- Acronym / sponsor ID
- SPIRE-2 / B1481038
- Conditions
- Cardiovascular Disease
- Keywords
- myocardial infarction, stroke, hyperlipidemia
- Phase
- Phase 3
- Study type
- Interventional
- Recruitment status
- TerminatedReason stopped: See Detailed Description
- Enrolment
- 10,564 participants (actual)
- Lead sponsor
- PfizerIndustry (pharma, biotech, devices)
- Study start
- 29 Oct 2013 (actual)
- Primary completion
- 3 Apr 2017 (actual)
- Study completion
- 3 Apr 2017 (actual)
- First posted
- 4 Nov 2013 (estimated)
- Results
- Posted 12 Jun 2018
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and unstable angina requiring urgent revascularization in high risk subjects who are receiving background lipid lowering therapy and have cholesterol laboratory values of LDL-C >/= 100 mg/dL (2.6 mmol/L) or non-HDL-C >/=130 mg/dL (3.4 mmol/L).
Detailed description
The trial was terminated prematurely on November 1, 2016, due to the emerging clinical profile and the evolving treatment and market landscape for lipid-lowering agents. These indicated that bococizumab was not likely to provide value to patients, physicians, or shareholders. The decision was not based on a recommendation by the independent Data Monitoring Committee to stop the program.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| bococizumab (PF-04950615) | Experimental | Drug: bococizumab (PF-04950615)150 mg, every 2 weeks, subcutaneous. |
| Placebo | Placebo comparator | Drug: PlaceboPlacebo comparator, every 2 weeks, subcutaneous. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Must be on background lipid lowering treatment.
- Must be at high risk of a CV event.
- Must have an LDL C >/=100 mg/dL (2.6 mmol/L) OR non HDL C >/=130 mg/dL (3.4 mmol/L).
Key exclusion criteria (5 listed)
- Planned coronary (PCI or CABG) or other arterial revascularization.
- New York Heart Association Class IV congestive heart failure or left ventricular ejection fraction < 25% by cardiac imaging.
- Chronic renal insufficiency with creatinine clearance of <30 ml/min/1.73m^2 by MDRD formula or with end state renal disease on dialysis.
- History of hemorrhagic stroke.
- Prior exposure to bococizumab or other investigational PCSK9 inhibitor.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| bococizumab (PF-04950615)Also: RN316150 mg, every 2 weeks, subcutaneous. The duration of the treatment period will depend upon reaching the targeted number of adjudicated and confirmed CV outcome events, approximately 3 to 4 years after the entry of first subject into the study. | Drug | bococizumab (PF-04950615) |
| PlaceboPlacebo comparator, every 2 weeks, subcutaneous. The duration of the treatment period will depend upon reaching the targeted number of adjudicated and confirmed CV outcome events, approximately 3 to 4 years after the entry of first subject into the study. | Drug | Placebo |
Primary outcome
Event Rate Per 100 Participant-years for First Occurrence of Major Cardiovascular (CV) Event
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of major CV event (maximum duration: up to 3.4 years)
Event rate per 100 participant-years for first occurrence of major CV event (adjudicated by Adjudication Committee) was reported. Major CV event was defined as any of the following: CV death [defined as sudden cardiac death, fatal myocardial infarction (MI), death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other CV causes] non-fatal MI, non-fatal stroke, and hospitalization for unstable angina needing urgent revascularization. Event rate was calculated as the number of events per 100 participant-years at risk.
26 secondary outcomes
Event Rate Per 100 Participant-years for First Occurrence of Composite Endpoint of Cardiovascular (CV) Death, Non-fatal Myocardial Infraction (MI) or Non-fatal Stroke
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of CV death, non-fatal MI or non-fatal stroke (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Composite Endpoint of All-cause Death, Non-fatal Myocardial Infraction (MI), Non-fatal Stroke or Hospitalization for Unstable Angina Needing Urgent Revascularization
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of all-cause death, non-fatal MI, non-fatal stroke or hospitalization for unstable angina needing urgent revascularization (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Composite Endpoint of All-cause Death, Non-fatal Myocardial Infarction (MI) or Non-fatal Stroke
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of all-cause death, non-fatal MI or non-fatal stroke (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Hospitalization for Unstable Angina Needing Urgent Revascularization
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for unstable angina needing urgent revascularization (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Composite Endpoint of Cardiovascular (CV) Death, Non-fatal Myocardial Infarction (MI), Non-fatal Stroke or Hospitalization for Unstable Angina
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of CV death, non-fatal MI, non-fatal stroke or hospitalization for unstable angina (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for Cardiovascular (CV) Death
Time frame: From baseline until the date of adjudicated and confirmed occurrence of CV death (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Any Myocardial Infarction (Fatal or Non-fatal)
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of any myocardial infarction (fatal or non-fatal) (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for Fatal Myocardial Infarction (MI)
Time frame: From baseline until the date of adjudicated and confirmed occurrence of fatal MI (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Non-fatal Myocardial Infarction (MI)
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of non-fatal MI (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Any Stroke (Fatal or Non-fatal)
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of any stroke (fatal or non-fatal) (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Any Stroke (Fatal or Non-fatal), of Any Etiology
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of any stroke (fatal or non-fatal) of any etiology (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for Fatal Stroke
Time frame: From baseline until the date of adjudicated and confirmed occurrence of fatal stroke (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Non-fatal Stroke
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of non-fatal stroke (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Hospitalization for Unstable Angina
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for unstable angina (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Hospitalization for Congestive Heart Failure (CHF)
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for CHF (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Coronary Revascularization
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of coronary revascularization (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Coronary Artery Bypass Graft Surgery (CABG)
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of CABG (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Percutaneous Coronary Intervention (PCI)
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of PCI (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for First Occurrence of Any Arterial Revascularizations
Time frame: From baseline until the date of first adjudicated and confirmed occurrence of any arterial revascularizations (maximum duration: up to 3.4 years)
Event Rate Per 100 Participant-years for All-cause Death
Time frame: From baseline until the date of adjudicated and confirmed occurrence of all-cause death (maximum duration: up to 3.4 years)
Percent Change From Baseline in Low Density Lipoprotein Cholesterol (LDL-C) at Week 14
Time frame: Baseline, Week 14
Nominal Change From Baseline in Low Density Lipoprotein Cholesterol (LDL-C) at Week 14
Time frame: Baseline, Week 14
Percent Change From Baseline in Low Density Lipoprotein Cholesterol (LDL-C) at Last Post-baseline Measurement
Time frame: Baseline, last post-baseline measurement (any time up to Week 140)
Percent Change From Baseline in Lipid Levels at Week 14
Time frame: Baseline, Week 14
Percent Change From Baseline in Log-transformed Triglycerides and Lipoprotein (a) (Lp[a]) at Week 14
Time frame: Baseline, Week 14
Percent Change From Baseline in Log-transformed High Sensitivity C-Reactive Protein (Hs-CRP) at Week 14
Time frame: Baseline, Week 14
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 May 2019.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Derived from this study: PubMed 35277540Chasman DI, Hyde CL, Giulianini F, Danning RD, Wang EQ, Hickling T, Ridker PM, Loomis AK. Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1. Sci Rep. 2022 Mar 11;12(1):4266. doi: 10.1038/s41598-022-07997-5.
- Derived from this study: PubMed 29716940Pradhan AD, Aday AW, Rose LM, Ridker PM. Residual Inflammatory Risk on Treatment With PCSK9 Inhibition and Statin Therapy. Circulation. 2018 Jul 10;138(2):141-149. doi: 10.1161/CIRCULATIONAHA.118.034645. Epub 2018 May 1.
- Derived from this study: PubMed 29685591Ridker PM, Rose LM, Kastelein JJP, Santos RD, Wei C, Revkin J, Yunis C, Tardif JC, Shear CL; Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Investigators. Cardiovascular event reduction with PCSK9 inhibition among 1578 patients with familial hypercholesterolemia: Results from the SPIRE randomized trials of bococizumab. J Clin Lipidol. 2018 Jul-Aug;12(4):958-965. doi: 10.1016/j.jacl.2018.03.088. Epub 2018 Apr 3.
- Derived from this study: PubMed 28304242Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC; SPIRE Cardiovascular Outcome Investigators. Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients. N Engl J Med. 2017 Apr 20;376(16):1527-1539. doi: 10.1056/NEJMoa1701488. Epub 2017 Mar 17.
- To obtain contact information for a study center near you, click here.Link provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Pfizer CT.gov Call Center study director
Pfizer
1,595 sites in 35 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 3 study testing bococizumab (PF-04950615) in people with Cardiovascular Disease, run by Pfizer at 1,595 sites in 35 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 1 May 2019. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1,595 sites in United States, Poland, Netherlands, Germany, Canada and 30 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
Yes. Results are posted in the registry (first posted 12 Jun 2018). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Event Rate Per 100 Participant-years for First Occurrence of Major Cardiovascular (CV) Event (time frame: From baseline until the date of first adjudicated and confirmed occurrence of major CV event (maximum duration: up to 3.4 years)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01975389, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 May 2019.