Cochlear Implant RecipientsNCT01876472
Differences in Music Perception Skills Between Child, Teen and Adult Cochlear Implant Recipients
An observational study of Cochlear Implant Recipients, run by University of Zurich at 1 site in Switzerland.
Trial summary
Adult recipients of cochlear implants (CI) generally loose interest in listening to music. This may be due to the rather limited spectral resolution of CI. However, child CI-recipients, if offered the opportunity, like to listen to music. Read more about this study
- Who is it for?
- Ages 3 to 70 years
- Conditions the study is for
- Cochlear Implant Recipients
- What is being tested?
- Assessment of music perception skills
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 50 participants
- Where
- 1 siteSwitzerland
- Study dates
- Nov 2011to Jul 2012
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 3 to 70 years
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Healthy CI recipients that receive their regular follow-ups in the ENT-clinic of the Zurich University Hospital.
Who may be able to join
- Participants are uni- or bilateral CI recipients.
- Participants are at least 3 years old.
- Participants received CI one or more years before.
- Participants are healthy.
- Participation in the study is voluntary.
- Participants and their legal custodians have read the information for participants at least one day prior to the test and given their written consent.
Who cannot join
- Surgery for CI carried out less than one year before the test.
- Children less than 3 years old.
- Reduced cognitive capabilities due to old age.
- Physical or mental handicaps.
Trial locations and contacts
1 site in 1 country.
Switzerland1 site
University Hospital Zurich,
Zurich, Canton of Zurich, 8091
About this study
Adult recipients of cochlear implants (CI) generally loose interest in listening to music. This may be due to the rather limited spectral resolution of CI. However, child CI-recipients, if offered the opportunity, like to listen to music. They participate actively in musical acitivities, such as singing, dancing or playing an instrument. Thus, there seems to be a fundamental difference in the music perception of people who receive CI as child or as adult.
This study assesses music perception skills of child, teen and adult cochlear implant recipients in settings with simple tone sequences and in a more complex, melodious context.
- Conditions
- Cochlear Implant Recipients
- Being tested
- Assessment of music perception skills
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Assessment of music perception skillsBehavioural
A sequence of tones is presented to participants. Then the same sequence is presented again, with the 4th tone being one to six half tones different from the first sequence. Participants are asked to indicate when they hear a difference betweent the first and the second sequence.
| Study group | Role | What they receive |
|---|---|---|
| Children aged 3 - 10 years | Assessment of music perception skills with cochlear implant recipients aged 3 - 10 years Receives: Behavioral: Assessment of music perception skills | |
| Teenagers aged 11 - 15 years | Assessment of music perception skills with cochlear implant recipients aged 11 - 15 years Receives: Behavioral: Assessment of music perception skills | |
| Adults aged 16 - 70 years | Assessment of music perception skills with cochlear implant recipients aged 16 - 70 years Receives: Behavioral: Assessment of music perception skills |
What is being measured
The primary outcome is the main question the study is designed to answer.
Does the age at which a person receives a cochlear implant influence music perception skills?
The test assesses wether cochlear implant carriers are able to hear the difference betweent two sequences of sounds, where in the second sequence on tone is different from the first sequence. If a difference is perceived, then the test assesses how big this difference has to be in order to be heard.
The first and the second test are no more than six months apart; both times the same procedure is followed.
The test is carried out with three age groups:
- Children aged 3-10 years
- Teenagers aged 11 - 14 years
- Persons above 15 years
Measured: Test and retest are taken within 6 months
Secondary outcomes (1)
Do the results of the primary outcome measure depend on the tone sequence presented to the cochlear implant recipients?
The test is carried out with three different tone sequences:
- Same tone at three different octaves (control tune: 131 Hz, 262 Hz, 523 Hz)
- Tune of rising, then falling notes
- Tune of rising notes only
Measured: Test and retest are no more than 6 months apart
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Jun 2013 (estimated)
- Study startNov 2011
- Primary completionJul 2012
- Study completionJul 2012
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (15)Papers the sponsor has linked to this study.
- Other trials for Cochlear Implant RecipientsStudies of the same condition, open and under way.
- More trials run by University of ZurichThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Zurich
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Dorothe Veraguth, MD, Principal investigator, University Hospital Zurich, Clinic for Otorhinolaryngology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01876472
- Sponsor's protocol ID
- VD_2011_11_15
- Status last verified
- May 2013
- First submitted
- 10 Jun 2013
- Last updated
- 12 Jun 2013
- Results posted
- No
- Data monitoring committee
- No
Publications
Svirsky MA, Robbins AM, Kirk KI, Pisoni DB, Miyamoto RT. Language development in profoundly deaf children with cochlear implants. Psychol Sci. 2000 Mar;11(2):153-8. doi: 10.1111/1467-9280.00231.
PubMed 11273423Nicholas JG, Geers AE. Effects of early auditory experience on the spoken language of deaf children at 3 years of age. Ear Hear. 2006 Jun;27(3):286-98. doi: 10.1097/01.aud.0000215973.76912.c6.
PubMed 16672797Svirsky MA, Teoh SW, Neuburger H. Development of language and speech perception in congenitally, profoundly deaf children as a function of age at cochlear implantation. Audiol Neurootol. 2004 Jul-Aug;9(4):224-33. doi: 10.1159/000078392.
PubMed 15205550Fujita S, Ito J. Ability of nucleus cochlear implantees to recognize music. Ann Otol Rhinol Laryngol. 1999 Jul;108(7 Pt 1):634-40. doi: 10.1177/000348949910800702.
PubMed 10435919Green T, Faulkner A, Rosen S. Spectral and temporal cues to pitch in noise-excited vocoder simulations of continuous-interleaved-sampling cochlear implants. J Acoust Soc Am. 2002 Nov;112(5 Pt 1):2155-64. doi: 10.1121/1.1506688.
PubMed 12430827Peretz I, Hyde KL. What is specific to music processing? Insights from congenital amusia. Trends Cogn Sci. 2003 Aug;7(8):362-367. doi: 10.1016/s1364-6613(03)00150-5.
PubMed 12907232Fitzsimons M, Sheahan N, Staunton H. Gender and the integration of acoustic dimensions of prosody: implications for clinical studies. Brain Lang. 2001 Jul;78(1):94-108. doi: 10.1006/brln.2000.2448.
PubMed 11412018Shannon RV, Zeng FG, Kamath V, Wygonski J, Ekelid M. Speech recognition with primarily temporal cues. Science. 1995 Oct 13;270(5234):303-4. doi: 10.1126/science.270.5234.303.
PubMed 7569981K. Gfeller, S. A. Witt, L. J. Spencer, J. Stordahl and B. Tomblin (1999), Musical Involvement and Enjoyment of Children Who Use Cochlear Implants, Volta Review, 100(4), pp. 213-233
Mitani C, Nakata T, Trehub SE, Kanda Y, Kumagami H, Takasaki K, Miyamoto I, Takahashi H. Music recognition, music listening, and word recognition by deaf children with cochlear implants. Ear Hear. 2007 Apr;28(2 Suppl):29S-33S. doi: 10.1097/AUD.0b013e318031547a.
PubMed 17496641Cooper WB, Tobey E, Loizou PC. Music perception by cochlear implant and normal hearing listeners as measured by the Montreal Battery for Evaluation of Amusia. Ear Hear. 2008 Aug;29(4):618-26. doi: 10.1097/AUD.0b013e318174e787.
PubMed 18469714Sharma A, Dorman MF, Kral A. The influence of a sensitive period on central auditory development in children with unilateral and bilateral cochlear implants. Hear Res. 2005 May;203(1-2):134-43. doi: 10.1016/j.heares.2004.12.010.
PubMed 15855038Looi V, She J. Music perception of cochlear implant users: a questionnaire, and its implications for a music training program. Int J Audiol. 2010 Feb;49(2):116-28. doi: 10.3109/14992020903405987.
PubMed 20151886Gfeller K, Turner C, Mehr M, Woodworth G, Fearn R, Knutson JF, Witt S, Stordahl J. Recognition of familiar melodies by adult cochlear implant recipients and normal-hearing adults. Cochlear Implants Int. 2002 Mar;3(1):29-53. doi: 10.1179/cim.2002.3.1.29.
PubMed 18792110Trehub SE, Cohen AJ, Thorpe LA, Morrongiello BA. Development of the perception of musical relations: semitone and diatonic structure. J Exp Psychol Hum Percept Perform. 1986 Aug;12(3):295-301. doi: 10.1037//0096-1523.12.3.295.
PubMed 2943857
Study at a glance
From the registry record, last updated by the sponsor on 12 Jun 2013. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Differences in Music Perception Skills Between Child, Teen and Adult Cochlear Implant Recipients
- ClinicalTrials.gov ID
- NCT01876472
- Acronym / sponsor ID
- VD_2011_11_15
- Conditions
- Cochlear Implant Recipients
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- University of ZurichUniversity, hospital or other
- Study start
- Nov 2011
- Primary completion
- Jul 2012 (actual)
- Study completion
- Jul 2012 (actual)
- First posted
- 12 Jun 2013 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Adult recipients of cochlear implants (CI) generally loose interest in listening to music. This may be due to the rather limited spectral resolution of CI. However, child CI-recipients, if offered the opportunity, like to listen to music. They participate actively in musical acitivities, such as singing, dancing or playing an instrument. Thus, there seems to be a fundamental difference in the music perception of people who receive CI as child or as adult.
This study assesses music perception skills of child, teen and adult cochlear implant recipients in settings with simple tone sequences and in a more complex, melodious context.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Children aged 3 - 10 years | – | Behavioral: Assessment of music perception skillsAssessment of music perception skills with cochlear implant recipients aged 3 - 10 years |
| Teenagers aged 11 - 15 years | – | Behavioral: Assessment of music perception skillsAssessment of music perception skills with cochlear implant recipients aged 11 - 15 years |
| Adults aged 16 - 70 years | – | Behavioral: Assessment of music perception skillsAssessment of music perception skills with cochlear implant recipients aged 16 - 70 years |
Who may qualify
- Ages
- 3 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Healthy CI recipients that receive their regular follow-ups in the ENT-clinic of the Zurich University Hospital.
Key inclusion criteria (6 listed)
- Participants are uni- or bilateral CI recipients.
- Participants are at least 3 years old.
- Participants received CI one or more years before.
- Participants are healthy.
- Participation in the study is voluntary.
Key exclusion criteria (4 listed)
- Surgery for CI carried out less than one year before the test.
- Children less than 3 years old.
- Reduced cognitive capabilities due to old age.
- Physical or mental handicaps.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Assessment of music perception skillsA sequence of tones is presented to participants. Then the same sequence is presented again, with the 4th tone being one to six half tones different from the first sequence. Participants are asked to indicate when they hear a difference betweent the first and the second sequence. | Behavioural | Adults aged 16 - 70 years, Children aged 3 - 10 years, Teenagers aged 11 - 15 years |
Primary outcome
Does the age at which a person receives a cochlear implant influence music perception skills?
Time frame: Test and retest are taken within 6 months
The test assesses wether cochlear implant carriers are able to hear the difference betweent two sequences of sounds, where in the second sequence on tone is different from the first sequence. If a difference is perceived, then the test assesses how big this difference has to be in order to be heard. The first and the second test are no more than six months apart; both times the same procedure is followed. The test is carried out with three age groups: 1. Children aged 3-10 years 2. Teenagers aged 11 - 14 years 3. Persons above 15 years
1 secondary outcome
Do the results of the primary outcome measure depend on the tone sequence presented to the cochlear implant recipients?
Time frame: Test and retest are no more than 6 months apart
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Jun 2013.
- Background: PubMed 11273423Svirsky MA, Robbins AM, Kirk KI, Pisoni DB, Miyamoto RT. Language development in profoundly deaf children with cochlear implants. Psychol Sci. 2000 Mar;11(2):153-8. doi: 10.1111/1467-9280.00231.
- Background: PubMed 16672797Nicholas JG, Geers AE. Effects of early auditory experience on the spoken language of deaf children at 3 years of age. Ear Hear. 2006 Jun;27(3):286-98. doi: 10.1097/01.aud.0000215973.76912.c6.
- Background: PubMed 15205550Svirsky MA, Teoh SW, Neuburger H. Development of language and speech perception in congenitally, profoundly deaf children as a function of age at cochlear implantation. Audiol Neurootol. 2004 Jul-Aug;9(4):224-33. doi: 10.1159/000078392.
- Background: PubMed 10435919Fujita S, Ito J. Ability of nucleus cochlear implantees to recognize music. Ann Otol Rhinol Laryngol. 1999 Jul;108(7 Pt 1):634-40. doi: 10.1177/000348949910800702.
- Background: PubMed 12430827Green T, Faulkner A, Rosen S. Spectral and temporal cues to pitch in noise-excited vocoder simulations of continuous-interleaved-sampling cochlear implants. J Acoust Soc Am. 2002 Nov;112(5 Pt 1):2155-64. doi: 10.1121/1.1506688.
- Background: PubMed 12907232Peretz I, Hyde KL. What is specific to music processing? Insights from congenital amusia. Trends Cogn Sci. 2003 Aug;7(8):362-367. doi: 10.1016/s1364-6613(03)00150-5.
- Background: PubMed 11412018Fitzsimons M, Sheahan N, Staunton H. Gender and the integration of acoustic dimensions of prosody: implications for clinical studies. Brain Lang. 2001 Jul;78(1):94-108. doi: 10.1006/brln.2000.2448.
- Background: PubMed 7569981Shannon RV, Zeng FG, Kamath V, Wygonski J, Ekelid M. Speech recognition with primarily temporal cues. Science. 1995 Oct 13;270(5234):303-4. doi: 10.1126/science.270.5234.303.
- BackgroundK. Gfeller, S. A. Witt, L. J. Spencer, J. Stordahl and B. Tomblin (1999), Musical Involvement and Enjoyment of Children Who Use Cochlear Implants, Volta Review, 100(4), pp. 213-233
- Background: PubMed 17496641Mitani C, Nakata T, Trehub SE, Kanda Y, Kumagami H, Takasaki K, Miyamoto I, Takahashi H. Music recognition, music listening, and word recognition by deaf children with cochlear implants. Ear Hear. 2007 Apr;28(2 Suppl):29S-33S. doi: 10.1097/AUD.0b013e318031547a.
- Background: PubMed 18469714Cooper WB, Tobey E, Loizou PC. Music perception by cochlear implant and normal hearing listeners as measured by the Montreal Battery for Evaluation of Amusia. Ear Hear. 2008 Aug;29(4):618-26. doi: 10.1097/AUD.0b013e318174e787.
- Background: PubMed 15855038Sharma A, Dorman MF, Kral A. The influence of a sensitive period on central auditory development in children with unilateral and bilateral cochlear implants. Hear Res. 2005 May;203(1-2):134-43. doi: 10.1016/j.heares.2004.12.010.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Dorothe Veraguth, MD principal investigator
University Hospital Zurich, Clinic for Otorhinolaryngology
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cochlear Implant Recipients, run by University of Zurich at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Jun 2013. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Does the age at which a person receives a cochlear implant influence music perception skills? (time frame: Test and retest are taken within 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01876472, which also lists 15 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Jun 2013.