StrokeNCT01855633
Repetitive Transcranial Magnetic Stimulation in Patients With Hemiplegic Stroke
A study testing Traditional Theta burst stimulation (TBS) and Modified TBS rTMS in people with Stroke, run by Dongtan Sacred Heart Hospital at 1 site in South Korea.
Trial summary
Stroke is one of the major causes of death in the World. Many stroke survivors may suffer from long-term sequelae of stroke such as hemiplegia. The effects of rehabilitation therapy are limited. The development of new treatment strategies is essential. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Stroke
- What is being tested?
- Traditional Theta burst stimulation (TBS) and Modified TBS rTMS
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 48 participants
- Where
- 1 siteSouth Korea
- Study dates
- 26 Apr 2013to Dec 2040
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- stroke patients with motor weakness
- Medical research council (MRC) grade 0-4
- More than 2 weeks after stroke onset
- Age 18 years and older
- Able to provide consent for the protocol
Who cannot join
- History of previous symptomatic stroke
- pregnant women
- Persons with surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), intracardiac lines that may pose a physical hazard during magnetic stimulation will also be excluded
- Patients with history of seizure disorder or epilepsy
- Subjects without the capacity to give informed consent
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
South Korea1 site, 1 recruiting
- Recruiting
Dongtan Sacred Heart Hospital
Hwaseong-si, Gyeonggi-do, 445-170
Suk Yun Kang, MD, PhD, 82-31-8086-2310, sukyunkang@hanmail.net
Ah-Young Jun, MD, MS, 82-31-8086-2310, ayjun@hallym.or.kr
About this study
Stroke is one of the major causes of death in the World. Many stroke survivors may suffer from long-term sequelae of stroke such as hemiplegia. The effects of rehabilitation therapy are limited. The development of new treatment strategies is essential. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive method to stimulate the focal area of the brain for restoring brain function. The aim of this study is to investigate the therapeutic effect of rTMS on the motor recovery in patients with hemiplegic stroke.
- Conditions
- Stroke
- Being tested
- Traditional Theta burst stimulation (TBS), Modified TBS rTMS, Sham rTMS
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Traditional Theta burst stimulation (TBS)Device
Modified TBS rTMSDevice
Sham rTMSDevice
| Study group | Role | What they receive |
|---|---|---|
| Tradtional Theta burst stimulation (TBS) rTMS | Experimental | Participants will receive continuous theta burst stimulation (cTBS) rTMS to contralesional hemisphere based on a previous study (Huang et al., 2005) Receives: Device: Traditional Theta burst stimulation (TBS) |
| Modified TBS rTMS | Active comparator | Participants will receive modified cTBS rTMS to contralesional hemisphere based on a previous study (Nyffeler et al., 2006) Receives: Device: Modified TBS rTMS |
| Sham rTMS | Sham comparator | Participants will receive sham cTBS rTMS to contralesional hemisphere. Receives: Device: Sham rTMS |
What is being measured
The primary outcome is the main question the study is designed to answer.
Keyboard tapping test
Participants will be asked to tap a key of a computer keyboard as fast as possible in five seconds. They will be asked to do three times. We will measure the number of tapping. The primary outcome will be the averaged data of the numbers.This will be done before and after 5-day rTMS intervention.
Measured: 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 May 2013 (estimated)
- Study start26 Apr 2013
- Primary completionDec 2039 (estimated)
- Study completionDec 2040 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 48 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Dongtan Sacred Heart Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Suk Yun Kang, Dongtan Sacred Heart Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01855633
- Sponsor's protocol ID
- 2013-019
- Status last verified
- Aug 2026
- First submitted
- 10 May 2013
- Last updated
- 27 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Repetitive Transcranial Magnetic Stimulation in Patients With Hemiplegic Stroke
- ClinicalTrials.gov ID
- NCT01855633
- Acronym / sponsor ID
- 2013-019
- Conditions
- Stroke
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 48 participants (estimated)
- Lead sponsor
- Dongtan Sacred Heart HospitalUniversity, hospital or other
- Study start
- 26 Apr 2013 (actual)
- Primary completion
- Dec 2039 (estimated)
- Study completion
- Dec 2040 (estimated)
- First posted
- 16 May 2013 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Stroke is one of the major causes of death in the World. Many stroke survivors may suffer from long-term sequelae of stroke such as hemiplegia. The effects of rehabilitation therapy are limited. The development of new treatment strategies is essential. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive method to stimulate the focal area of the brain for restoring brain function. The aim of this study is to investigate the therapeutic effect of rTMS on the motor recovery in patients with hemiplegic stroke.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Tradtional Theta burst stimulation (TBS) rTMS | Experimental | Device: Traditional Theta burst stimulation (TBS)Participants will receive continuous theta burst stimulation (cTBS) rTMS to contralesional hemisphere based on a previous study (Huang et al., 2005) |
| Modified TBS rTMS | Active comparator | Device: Modified TBS rTMSParticipants will receive modified cTBS rTMS to contralesional hemisphere based on a previous study (Nyffeler et al., 2006) |
| Sham rTMS | Sham comparator | Device: Sham rTMSParticipants will receive sham cTBS rTMS to contralesional hemisphere. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- stroke patients with motor weakness
- Medical research council (MRC) grade 0-4
- More than 2 weeks after stroke onset
- Age 18 years and older
- Able to provide consent for the protocol
Key exclusion criteria (5 listed)
- History of previous symptomatic stroke
- pregnant women
- Persons with surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), intracardiac lines that may pose a physical hazard during magnetic stimulation will also be excluded
- Patients with history of seizure disorder or epilepsy
- Subjects without the capacity to give informed consent
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Traditional Theta burst stimulation (TBS) | Device | Tradtional Theta burst stimulation (TBS) rTMS |
| Modified TBS rTMS | Device | Modified TBS rTMS |
| Sham rTMS | Device | Sham rTMS |
Primary outcome
Keyboard tapping test
Time frame: 1 day
Participants will be asked to tap a key of a computer keyboard as fast as possible in five seconds. They will be asked to do three times. We will measure the number of tapping. The primary outcome will be the averaged data of the numbers.This will be done before and after 5-day rTMS intervention.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Traditional Theta burst stimulation (TBS) and Modified TBS rTMS in people with Stroke, run by Dongtan Sacred Heart Hospital at 1 site in South Korea.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in South Korea. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Suk Yun Kang, MD, PhD (82-31-8086-2310, sukyunkang@hanmail.net), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Keyboard tapping test (time frame: 1 day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Aug 2026.