PeriodontitisNCT01358630
Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities
An observational study of Periodontitis and Vascular Disease, run by University of Oslo at 1 site in Norway.
Trial summary
The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular (ACD) and aneurysmal diseases. Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Periodontitis, Vascular Disease
- How many people
- 100 participants
- Where
- 1 siteNorway
- Study dates
- Oct 2008to Oct 2015
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis, and randomly selected blood donors at Oslo University Hospital, Ullevål.
Who may be able to join
- Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis,
Who cannot join
- patients whom undergone antibiotic treatment the past month.
- patients whom undergone periodontal treatment the past 6 months.
- patients with no teeth
Trial locations and contacts
1 site in 1 country.
Norway1 site, 1 recruiting
- Recruiting
Dental and Medical Faculty, University of Oslo
Oslo, Oslo, 0316
Ingar Olsen, Prof.PhD, 47 22 84 03 50, ingaro@odont.uio.no
Jørgensen J Jørgensen, Prof.PhD, 47 22 89 44 96, j.j.jorgensen@medisin.uio.no
About this study
Official title: Periodontal-, Cardiovascular- and Aneurysmal Diseases.
The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular (ACD) and aneurysmal diseases. The investigators will also try to identify oral bacteria in atherosclerotic plaques and aneurysmal walls and thrombus. Histological analyses of atherosclerotic plaques and aneurysmal wall will be performed.
- Conditions
- Periodontitis, Vascular Disease
- Keywords
- Periodontitis, Vascular disease, Proinflammatory cytokines
- Medical subject headings
- Periodontitis, Vascular Diseases
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 May 2011 (estimated)
- Study startOct 2008
- Primary completionMar 2011
- Study completionOct 2015 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PeriodontitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Oslo
- Sponsor type
- University, hospital or other
- Collaborators
- Oslo University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01358630
- Sponsor's protocol ID
- 08/322b
- Status last verified
- Nov 2010
- First submitted
- 19 May 2011
- Last updated
- 24 May 2011
- Results posted
- No
- Data monitoring committee
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 24 May 2011. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Periodontal-, Cardiovascular- and Aneurysmal Diseases.
- ClinicalTrials.gov ID
- NCT01358630
- Acronym / sponsor ID
- 08/322b
- Conditions
- Periodontitis, Vascular Disease
- Keywords
- Periodontitis, Vascular disease, Proinflammatory cytokines
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- University of OsloUniversity, hospital or other
- Collaborators
- Oslo University Hospital
- Study start
- Oct 2008
- Primary completion
- Mar 2011 (actual)
- Study completion
- Oct 2015 (estimated)
- First posted
- 24 May 2011 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular (ACD) and aneurysmal diseases. The investigators will also try to identify oral bacteria in atherosclerotic plaques and aneurysmal walls and thrombus. Histological analyses of atherosclerotic plaques and aneurysmal wall will be performed.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis, and randomly selected blood donors at Oslo University Hospital, Ullevål.
Key inclusion criteria (1 listed)
- Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis,
Key exclusion criteria (3 listed)
- patients whom undergone antibiotic treatment the past month.
- patients whom undergone periodontal treatment the past 6 months.
- patients with no teeth
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 May 2011.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Periodontitis and Vascular Disease, run by University of Oslo at 1 site in Norway.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 24 May 2011. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Norway. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Ingar Olsen, Prof.PhD. (+47-22840350, ingar.olsen@odont.uio.no), or a site near the patient. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 May 2011; AzTrials last refreshed its copy on 7 Nov 2026.